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226 results on '"Arvanitis, Marios"'

1. Validation of human telomere length multi-ancestry meta-analysis association signals identifies POP5 and KBTBD6 as human telomere length regulation genes

Author

Keener, Rebecca, Chhetri, Surya B., Connelly, Carla J., Taub, Margaret A., Conomos, Matthew P., Weinstock, Joshua, Ni, Bohan, Strober, Benjamin, Aslibekyan, Stella, Auer, Paul L., Barwick, Lucas, Becker, Lewis C., Blangero, John, Bleecker, Eugene R., Brody, Jennifer A., Cade, Brian E., Celedon, Juan C., Chang, Yi-Cheng, Cupples, L. Adrienne, Custer, Brian, Freedman, Barry I., Gladwin, Mark T., Heckbert, Susan R., Hou, Lifang, Irvin, Marguerite R., Isasi, Carmen R., Johnsen, Jill M., Kenny, Eimear E., Kooperberg, Charles, Minster, Ryan L., Naseri, Take, Viali, Satupa’itea, Nekhai, Sergei, Pankratz, Nathan, Peyser, Patricia A., Taylor, Kent D., Telen, Marilyn J., Wu, Baojun, Yanek, Lisa R., Yang, Ivana V., Albert, Christine, Arnett, Donna K., Ashley-Koch, Allison E., Barnes, Kathleen C., Bis, Joshua C., Blackwell, Thomas W., Boerwinkle, Eric, Burchard, Esteban G., Carson, April P., Chen, Zhanghua, Chen, Yii-Der Ida, Darbar, Dawood, de Andrade, Mariza, Ellinor, Patrick T., Fornage, Myriam, Gelb, Bruce D., Gilliland, Frank D., He, Jiang, Islam, Talat, Kaab, Stefan, Kardia, Sharon L. R., Kelly, Shannon, Konkle, Barbara A., Kumar, Rajesh, Loos, Ruth J. F., Martinez, Fernando D., McGarvey, Stephen T., Meyers, Deborah A., Mitchell, Braxton D., Montgomery, Courtney G., North, Kari E., Palmer, Nicholette D., Peralta, Juan M., Raby, Benjamin A., Redline, Susan, Rich, Stephen S., Roden, Dan, Rotter, Jerome I., Ruczinski, Ingo, Schwartz, David, Sciurba, Frank, Shoemaker, M. Benjamin, Silverman, Edwin K., Sinner, Moritz F., Smith, Nicholas L., Smith, Albert V., Tiwari, Hemant K., Vasan, Ramachandran S., Weiss, Scott T., Williams, L. Keoki, Zhang, Yingze, Ziv, Elad, Raffield, Laura M., Reiner, Alexander P., Arvanitis, Marios, Greider, Carol W., Mathias, Rasika A., and Battle, Alexis

Published
2024
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3. The functional impact of rare variation across the regulatory cascade

Author

Li, Taibo, Ferraro, Nicole, Strober, Benjamin J, Aguet, Francois, Kasela, Silva, Arvanitis, Marios, Ni, Bohan, Wiel, Laurens, Hershberg, Elliot, Ardlie, Kristin, Arking, Dan E, Beer, Rebecca L, Brody, Jennifer, Blackwell, Thomas W, Clish, Clary, Gabriel, Stacey, Gerszten, Robert, Guo, Xiuqing, Gupta, Namrata, Johnson, W Craig, Lappalainen, Tuuli, Lin, Henry J, Liu, Yongmei, Nickerson, Deborah A, Papanicolaou, George, Pritchard, Jonathan K, Qasba, Pankaj, Shojaie, Ali, Smith, Josh, Sotoodehnia, Nona, Taylor, Kent D, Tracy, Russell P, Van Den Berg, David, Wheeler, Matthew T, Rich, Stephen S, Rotter, Jerome I, Battle, Alexis, and Montgomery, Stephen B

Subjects
Biological Sciences, Health Sciences, Genetics, Brain Disorders, Human Genome, Biotechnology, Aging, 2.1 Biological and endogenous factors, 2.5 Research design and methodologies (aetiology), Generic health relevance, functional genomics, machine learning, methylome, multi-omics, proteome, rare variants, transcriptome
Abstract

Each human genome has tens of thousands of rare genetic variants; however, identifying impactful rare variants remains a major challenge. We demonstrate how use of personal multi-omics can enable identification of impactful rare variants by using the Multi-Ethnic Study of Atherosclerosis, which included several hundred individuals, with whole-genome sequencing, transcriptomes, methylomes, and proteomes collected across two time points, 10 years apart. We evaluated each multi-omics phenotype's ability to separately and jointly inform functional rare variation. By combining expression and protein data, we observed rare stop variants 62 times and rare frameshift variants 216 times as frequently as controls, compared to 13-27 times as frequently for expression or protein effects alone. We extended a Bayesian hierarchical model, "Watershed," to prioritize specific rare variants underlying multi-omics signals across the regulatory cascade. With this approach, we identified rare variants that exhibited large effect sizes on multiple complex traits including height, schizophrenia, and Alzheimer's disease.

Published
2023

6. Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed

Author

Taub, Margaret A, Conomos, Matthew P, Keener, Rebecca, Iyer, Kruthika R, Weinstock, Joshua S, Yanek, Lisa R, Lane, John, Miller-Fleming, Tyne W, Brody, Jennifer A, Raffield, Laura M, McHugh, Caitlin P, Jain, Deepti, Gogarten, Stephanie M, Laurie, Cecelia A, Keramati, Ali, Arvanitis, Marios, Smith, Albert V, Heavner, Benjamin, Barwick, Lucas, Becker, Lewis C, Bis, Joshua C, Blangero, John, Bleecker, Eugene R, Burchard, Esteban G, Celedón, Juan C, Chang, Yen Pei C, Custer, Brian, Darbar, Dawood, de las Fuentes, Lisa, DeMeo, Dawn L, Freedman, Barry I, Garrett, Melanie E, Gladwin, Mark T, Heckbert, Susan R, Hidalgo, Bertha A, Irvin, Marguerite R, Islam, Talat, Johnson, W Craig, Kaab, Stefan, Launer, Lenore, Lee, Jiwon, Liu, Simin, Moscati, Arden, North, Kari E, Peyser, Patricia A, Rafaels, Nicholas, Seidman, Christine, Weeks, Daniel E, Wen, Fayun, Wheeler, Marsha M, Williams, L Keoki, Yang, Ivana V, Zhao, Wei, Aslibekyan, Stella, Auer, Paul L, Bowden, Donald W, Cade, Brian E, Chen, Zhanghua, Cho, Michael H, Cupples, L Adrienne, Curran, Joanne E, Daya, Michelle, Deka, Ranjan, Eng, Celeste, Fingerlin, Tasha E, Guo, Xiuqing, Hou, Lifang, Hwang, Shih-Jen, Johnsen, Jill M, Kenny, Eimear E, Levin, Albert M, Liu, Chunyu, Minster, Ryan L, Naseri, Take, Nouraie, Mehdi, Reupena, Muagututi A Sefuiva, Sabino, Ester C, Smith, Jennifer A, Smith, Nicholas L, Lasky-Su, Jessica, Taylor, James G, Telen, Marilyn J, Tiwari, Hemant K, Tracy, Russell P, White, Marquitta J, Zhang, Yingze, Wiggins, Kerri L, Weiss, Scott T, Vasan, Ramachandran S, Taylor, Kent D, Sinner, Moritz F, Silverman, Edwin K, Shoemaker, M Benjamin, Sheu, Wayne H-H, Sciurba, Frank, Schwartz, David A, Rotter, Jerome I, Roden, Daniel, Redline, Susan, and Raby, Benjamin A

Subjects
Epidemiology, Biological Sciences, Health Sciences, Genetics, Human Genome, Biotechnology, Aetiology, 2.1 Biological and endogenous factors, Generic health relevance, Good Health and Well Being, NHLBI CARE Network, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Hematology and Hemostasis Working Group, TOPMed Structural Variation Working Group
Abstract

Genetic studies on telomere length are important for understanding age-related diseases. Prior GWAS for leukocyte TL have been limited to European and Asian populations. Here, we report the first sequencing-based association study for TL across ancestrally-diverse individuals (European, African, Asian and Hispanic/Latino) from the NHLBI Trans-Omics for Precision Medicine (TOPMed) program. We used whole genome sequencing (WGS) of whole blood for variant genotype calling and the bioinformatic estimation of telomere length in n=109,122 individuals. We identified 59 sentinel variants (p-value

Published
2022

7. A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels

Author

Abe, Namiko, Abecasis, Gonçalo, Aguet, Francois, Albert, Christine, Almasy, Laura, Alonso, Alvaro, Ament, Seth, Anderson, Peter, Anugu, Pramod, Applebaum-Bowden, Deborah, Ardlie, Kristin, Arking, Dan, Arnett, Donna K, Ashley-Koch, Allison, Aslibekyan, Stella, Assimes, Tim, Auer, Paul, Avramopoulos, Dimitrios, Ayas, Najib, Balasubramanian, Adithya, Barnard, John, Barnes, Kathleen, Barr, R. Graham, Barron-Casella, Emily, Barwick, Lucas, Beaty, Terri, Beck, Gerald, Becker, Diane, Becker, Lewis, Beer, Rebecca, Beitelshees, Amber, Benjamin, Emelia, Benos, Takis, Bezerra, Marcos, Bielak, Larry, Bis, Joshua, Blackwell, Thomas, Blangero, John, Blue, Nathan, Boerwinkle, Eric, Bowden, Donald W., Bowler, Russell, Brody, Jennifer, Broeckel, Ulrich, Broome, Jai, Brown, Deborah, Bunting, Karen, Burchard, Esteban, Bustamante, Carlos, Buth, Erin, Cade, Brian, Cardwell, Jonathan, Carey, Vincent, Carrier, Julie, Carson, April P., Carty, Cara, Casaburi, Richard, Casas Romero, Juan P, Casella, James, Castaldi, Peter, Chaffin, Mark, Chang, Christy, Chang, Yi-Cheng, Chasman, Daniel, Chavan, Sameer, Chen, Bo-Juen, Chen, Wei-Min, Ida Chen, Yii-Der, Cho, Michael, Choi, Seung Hoan, Chuang, Lee-Ming, Chung, Mina, Chung, Ren-Hua, Clish, Clary, Comhair, Suzy, Conomos, Matthew, Cornell, Elaine, Correa, Adolfo, Crandall, Carolyn, Crapo, James, Cupples, L. Adrienne, Curran, Joanne, Curtis, Jeffrey, Custer, Brian, Damcott, Coleen, Darbar, Dawood, David, Sean, Davis, Colleen, Daya, Michelle, de Andrade, Mariza, de las Fuentes, Lisa, de Vries, Paul, DeBaun, Michael, Deka, Ranjan, DeMeo, Dawn, Devine, Scott, Dinh, Huyen, Doddapaneni, Harsha, Duan, Qing, Dugan-Perez, Shannon, Duggirala, Ravi, Durda, Jon Peter, Dutcher, Susan K., Eaton, Charles, Ekunwe, Lynette, El Boueiz, Adel, Ellinor, Patrick, Emery, Leslie, Erzurum, Serpil, Farber, Charles, Farek, Jesse, Fingerlin, Tasha, Flickinger, Matthew, Fornage, Myriam, Franceschini, Nora, Frazar, Chris, Fu, Mao, Fullerton, Stephanie M., Fulton, Lucinda, Gabriel, Stacey, Gan, Weiniu, Gao, Shanshan, Gao, Yan, Gass, Margery, Geiger, Heather, Gelb, Bruce, Geraci, Mark, Germer, Soren, Gerszten, Robert, Ghosh, Auyon, Gibbs, Richard, Gignoux, Chris, Gladwin, Mark, Glahn, David, Gogarten, Stephanie, Gong, Da-Wei, Goring, Harald, Graw, Sharon, Gray, Kathryn J., Grine, Daniel, Gross, Colin, Gu, C. Charles, Guan, Yue, Guo, Xiuqing, Gupta, Namrata, Haessler, Jeff, Hall, Michael, Han, Yi, Hanly, Patrick, Harris, Daniel, Hawley, Nicola L., He, Jiang, Heavner, Ben, Heckbert, Susan, Hernandez, Ryan, Herrington, David, Hersh, Craig, Hidalgo, Bertha, Hixson, James, Hobbs, Brian, Hokanson, John, Hong, Elliott, Hoth, Karin, Hsiung, Chao (Agnes), Hu, Jianhong, Hung, Yi-Jen, Huston, Haley, Hwu, Chii Min, Irvin, Marguerite Ryan, Jackson, Rebecca, Jain, Deepti, Jaquish, Cashell, Johnsen, Jill, Johnson, Andrew, Johnson, Craig, Johnston, Rich, Jones, Kimberly, Kang, Hyun Min, Kaplan, Robert, Kardia, Sharon, Kelly, Shannon, Kenny, Eimear, Kessler, Michael, Khan, Alyna, Khan, Ziad, Kim, Wonji, Kimoff, John, Kinney, Greg, Konkle, Barbara, Kooperberg, Charles, Kramer, Holly, Lange, Christoph, Lange, Ethan, Lange, Leslie, Laurie, Cathy, Laurie, Cecelia, LeBoff, Meryl, Lee, Jiwon, Lee, Sandra, Lee, Wen-Jane, LeFaive, Jonathon, Levine, David, Levy, Dan, Lewis, Joshua, Li, Xiaohui, Li, Yun, Lin, Henry, Lin, Honghuang, Lin, Xihong, Liu, Simin, Liu, Yongmei, Liu, Yu, Loos, Ruth J. F., Lubitz, Steven, Lunetta, Kathryn, Luo, James, Magalang, Ulysses, Mahaney, Michael, Make, Barry, Manichaikul, Ani, Manning, Alisa, Manson, JoAnn, Martin, Lisa, Marton, Melissa, Mathai, Susan, Mathias, Rasika, May, Susanne, McArdle, Patrick, McDonald, Merry-Lynn, McFarland, Sean, McGarvey, Stephen, McGoldrick, Daniel, McHugh, Caitlin, McNeil, Becky, Mei, Hao, Meigs, James, Menon, Vipin, Mestroni, Luisa, Metcalf, Ginger, Meyers, Deborah A, Mignot, Emmanuel, Mikulla, Julie, Min, Nancy, Minear, Mollie, Minster, Ryan L, Mitchell, Braxton D., Moll, Matt, Momin, Zeineen, Montasser, May E., Montgomery, Courtney, Muzny, Donna, Mychaleckyj, Josyf C, Nadkarni, Girish, Naik, Rakhi, Naseri, Take, Natarajan, Pradeep, Nekhai, Sergei, Nelson, Sarah C., Neltner, Bonnie, Nessner, Caitlin, Nickerson, Deborah, Nkechinyere, Osuji, North, Kari, O'Connell, Jeff, O'Connor, Tim, Ochs-Balcom, Heather, Okwuonu, Geoffrey, Pack, Allan, Paik, David T., Palmer, Nicholette, Pankow, James, Papanicolaou, George, Parker, Cora, Peloso, Gina, Peralta, Juan Manuel, Perez, Marco, Perry, James, Peters, Ulrike, Peyser, Patricia, Phillips, Lawrence S, Pleiness, Jacob, Pollin, Toni, Post, Wendy, Becker, Julia Powers, Boorgula, Meher Preethi, Preuss, Michael, Psaty, Bruce, Qasba, Pankaj, Qiao, Dandi, Qin, Zhaohui, Rafaels, Nicholas, Raffield, Laura, Rajendran, Mahitha, Ramachandran, Vasan S., Rao, D. C., Rasmussen-Torvik, Laura, Ratan, Aakrosh, Redline, Susan, Reed, Robert, Reeves, Catherine, Regan, Elizabeth, Reiner, Alex, Reupena, Muagututi‘a Sefuiva, Rice, Ken, Rich, Stephen, Robillard, Rebecca, Robine, Nicolas, Roden, Dan, Roselli, Carolina, Rotter, Jerome, Ruczinski, Ingo, Runnels, Alexi, Russell, Pamela, Ruuska, Sarah, Ryan, Kathleen, Sabino, Ester Cerdeira, Saleheen, Danish, Salimi, Shabnam, Salvi, Sejal, Salzberg, Steven, Sandow, Kevin, Sankaran, Vijay G., Santibanez, Jireh, Schwander, Karen, Schwartz, David, Sciurba, Frank, Seidman, Christine, Seidman, Jonathan, Sériès, Frédéric, Sheehan, Vivien, Sherman, Stephanie L., Shetty, Amol, Shetty, Aniket, Hui-Heng Sheu, Wayne, Shoemaker, M. Benjamin, Silver, Brian, Silverman, Edwin, Skomro, Robert, Smith, Albert Vernon, Smith, Jennifer, Smith, Josh, Smith, Nicholas, Smith, Tanja, Smoller, Sylvia, Snively, Beverly, Snyder, Michael, Sofer, Tamar, Sotoodehnia, Nona, Stilp, Adrienne M., Storm, Garrett, Streeten, Elizabeth, Su, Jessica Lasky, Sung, Yun Ju, Sylvia, Jody, Szpiro, Adam, Taliun, Daniel, Tang, Hua, Taub, Margaret, Taylor, Kent D., Taylor, Matthew, Taylor, Simeon, Telen, Marilyn, Thornton, Timothy A., Threlkeld, Machiko, Tinker, Lesley, Tirschwell, David, Tishkoff, Sarah, Tiwari, Hemant, Tong, Catherine, Tracy, Russell, Tsai, Michael, Vaidya, Dhananjay, Van Den Berg, David, VandeHaar, Peter, Vrieze, Scott, Walker, Tarik, Wallace, Robert, Walts, Avram, Wang, Fei Fei, Wang, Heming, Wang, Jiongming, Watson, Karol, Watt, Jennifer, Weeks, Daniel E., Weinstock, Joshua, Weir, Bruce, Weiss, Scott T, Weng, Lu-Chen, Wessel, Jennifer, Willer, Cristen, Williams, Kayleen, Williams, L. Keoki, Wilson, Carla, Wilson, James, Winterkorn, Lara, Wong, Quenna, Wu, Joseph, Xu, Huichun, Yanek, Lisa, Yang, Ivana, Yu, Ketian, Zekavat, Seyedeh Maryam, Zhang, Yingze, Zhao, Snow Xueyan, Zhao, Wei, Zhu, Xiaofeng, Ziv, Elad, Zody, Michael, Zoellner, Sebastian, Lindstrom, Sara, Wang, Lu, Smith, Erin N., Gordon, William, van Hylckama Vlieg, Astrid, Brody, Jennifer A., Pattee, Jack W., Haessler, Jeffrey, Brumpton, Ben M., Chasman, Daniel I., Suchon, Pierre, Chen, Ming-Huei, Turman, Constance, Germain, Marine, Wiggins, Kerri L., MacDonald, James, Braekkan, Sigrid K., Armasu, Sebastian M., Pankratz, Nathan, Jackson, Rabecca D., Nielsen, Jonas B., Giulianini, Franco, Puurunen, Marja K., Ibrahim, Manal, Heckbert, Susan R., Bammler, Theo K., Frazer, Kelly A., McCauley, Bryan M., Taylor, Kent, Pankow, James S., Reiner, Alexander P., Gabrielsen, Maiken E., Deleuze, Jean-François, O'Donnell, Chris J., Kim, Jihye, McKnight, Barbara, Kraft, Peter, Hansen, John-Bjarne, Rosendaal, Frits R., Heit, John A., Psaty, Bruce M., Tang, Weihong, Hveem, Kristian, Ridker, Paul M., Morange, Pierre-Emmanuel, Johnson, Andrew D., Kabrhel, Christopher, AlexandreTrégouët, David, Smith, Nicholas L., de Vries, Paul S., Reventun, Paula, Brown, Michael R., Heath, Adam S., Huffman, Jennifer E., Le, Ngoc-Quynh, Bebo, Allison, Temprano-Sagrera, Gerard, Raffield, Laura M., Ozel, Ayse Bilge, Thibord, Florian, Lewis, Joshua P., Rodriguez, Benjamin A. T., Polasek, Ozren, Yanek, Lisa R., Carrasquilla, German D., Marioni, Riccardo E., Kleber, Marcus E., Trégouët, David-Alexandre, Yao, Jie, Li-Gao, Ruifang, Joshi, Peter K., Trompet, Stella, Martinez-Perez, Angel, Ghanbari, Mohsen, Howard, Tom E., Reiner, Alex P., Arvanitis, Marios, Ryan, Kathleen A., Bartz, Traci M., Rudan, Igor, Faraday, Nauder, Linneberg, Allan, Davies, Gail, Delgado, Graciela E., Klaric, Lucija, Noordam, Raymond, van Rooij, Frank, Curran, Joanne E., Wheeler, Marsha M., Osburn, William O., O'Connell, Jeffrey R., Beswick, Andrew, Kolcic, Ivana, Souto, Juan Carlos, Becker, Lewis C., Hansen, Torben, Doyle, Margaret F., Harris, Sarah E., Moissl, Angela P., Rich, Stephen S., Campbell, Harry, Stott, David J., Soria, Jose Manuel, de Maat, Moniek P. M., Brody, Lawrence C., Auer, Paul L., Ben-Shlomo, Yoav, Hayward, Caroline, Mathias, Rasika A., Kilpeläinen, Tuomas O., Lange, Leslie A., Cox, Simon R., März, Winfried, Rotter, Jerome I., Mook-Kanamori, Dennis O., Wilson, James F., van der Harst, Pim, Jukema, J. Wouter, Ikram, M. Arfan, Desch, Karl C., Sabater-Lleal, Maria, Lowenstein, Charles J., and Morrison, Alanna C.

Published
2024
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8. De novo mutations across 1,465 diverse genomes reveal mutational insights and reductions in the Amish founder population

Author

Kessler, Michael D, Loesch, Douglas P, Perry, James A, Heard-Costa, Nancy L, Taliun, Daniel, Cade, Brian E, Wang, Heming, Daya, Michelle, Ziniti, John, Datta, Soma, Celedón, Juan C, Soto-Quiros, Manuel E, Avila, Lydiana, Weiss, Scott T, Barnes, Kathleen, Redline, Susan S, Vasan, Ramachandran S, Johnson, Andrew D, Mathias, Rasika A, Hernandez, Ryan, Wilson, James G, Nickerson, Deborah A, Abecasis, Goncalo, Browning, Sharon R, Zöllner, Sebastian, O’Connell, Jeffrey R, Mitchell, Braxton D, Lung, and Blood Institute Trans-Omics for Precision Medicine Consortium National Heart, Group, TOPMed Population Genetics Working, O’Connor, Timothy D, Aalbers, Sanne, Abdalla, Moustafa, Abdul-Rahman, Omar, Abecasis, Gonçalo, Abhyankar, Avinash, Adrianto, Indra, Aguet, Francois, Akers, Rachel, Al-Tobasei, Rafet, Albert, Christine, Aldred, Micheala, Almasy, Laura, Almeida, Marcio, Alonso, Alvaro, Ament, Seth, Ampleford, Elizabeth, An, Ping, Anderson, Christopher D, Andersson, Charlotte, Anugu, Pramod, Appelbaum, Elizabeth, Ardlie, Kristin, Arking, Dan, Armasu, Sebastian M, Arnett, Donna K, Arruda, Heather, Arvanitis, Marios, Ashley-Koch, Allison, Ashrani, Aneel, Aslibekyan, Stella, Assimes, Tim, Atkinson, Elizabeth, Auer, Paul, Austin, Thomas R, Avery, Christy, Avila-Pacheco, Julian, Avillach, Paul, Aviv, Abraham, Avramopoulos, Dimitrios, Ballantyne, Christie, Balte, Pallavi, Bamshad, Michael, Bancks, Mike, Barnard, John, Barr, R Graham, Barron-Casella, Emily, Bartz, Traci, Barwick, Lucas, Basu, Saonli, Battle, Alexis, Baumann, Michael, Beame, David, Beaty, Terri, Beck, Gerald, Becker, Lewis, Becker, Diane, Beer, Rebecca, Begum, Ferdouse, Beiser, Alexa, Beitelshees, Amber, Benjamin, Emelia, Benos, Takis, Berk-Rauch, Hanna, Besich, Zachary M, Bezerra, Marcos, Bhatt, Surya, Bi, Wenjian, Bick, Alexander, and Bielak, Larry

Subjects
Biological Sciences, Genetics, Biotechnology, Human Genome, Precision Medicine, 2.1 Biological and endogenous factors, Good Health and Well Being, Adult, Amish, Cohort Studies, DNA Mutational Analysis, Female, Genetics, Population, Genome, Human, Heterozygote, Humans, Male, Mutation, Pedigree, Whole Genome Sequencing, Young Adult, National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Population Genetics Working Group, de novo mutations, diversity, mutation rate, recombination
Abstract

De novo mutations (DNMs), or mutations that appear in an individual despite not being seen in their parents, are an important source of genetic variation whose impact is relevant to studies of human evolution, genetics, and disease. Utilizing high-coverage whole-genome sequencing data as part of the Trans-Omics for Precision Medicine (TOPMed) Program, we called 93,325 single-nucleotide DNMs across 1,465 trios from an array of diverse human populations, and used them to directly estimate and analyze DNM counts, rates, and spectra. We find a significant positive correlation between local recombination rate and local DNM rate, and that DNM rate explains a substantial portion (8.98 to 34.92%, depending on the model) of the genome-wide variation in population-level genetic variation from 41K unrelated TOPMed samples. Genome-wide heterozygosity does correlate with DNM rate, but only explains

Published
2020

11. Prioritization of causal genes from genome-wide association studies by Bayesian data integration across loci.

Author

Mousavi, Zeinab, Arvanitis, Marios, Duong, ThuyVy, Brody, Jennifer A., Battle, Alexis, Sotoodehnia, Nona, Shojaie, Ali, Arking, Dan E., and Bader, Joel S.

Subjects
*LOCUS (Genetics), *GENETIC variation, *HUMAN genome, *GENE regulatory networks, *GENOME-wide association studies
Abstract

Motivation: Genome-wide association studies (GWAS) have identified genetic variants, usually single-nucleotide polymorphisms (SNPs), associated with human traits, including disease and disease risk. These variants (or causal variants in linkage disequilibrium with them) usually affect the regulation or function of a nearby gene. A GWAS locus can span many genes, however, and prioritizing which gene or genes in a locus are most likely to be causal remains a challenge. Better prioritization and prediction of causal genes could reveal disease mechanisms and suggest interventions. Results: We describe a new Bayesian method, termed SigNet for significance networks, that combines information both within and across loci to identify the most likely causal gene at each locus. The SigNet method builds on existing methods that focus on individual loci with evidence from gene distance and expression quantitative trait loci (eQTL) by sharing information across loci using protein-protein and gene regulatory interaction network data. In an application to cardiac electrophysiology with 226 GWAS loci, only 46 (20%) have within-locus evidence from Mendelian genes, protein-coding changes, or colocalization with eQTL signals. At the remaining 180 loci lacking functional information, SigNet selects 56 genes other than the minimum distance gene, equal to 31% of the information-poor loci and 25% of the GWAS loci overall. Assessment by pathway enrichment demonstrates improved performance by SigNet. Review of individual loci shows literature evidence for genes selected by SigNet, including PMP22 as a novel causal gene candidate. Author summary: A motivation for the Human Genome Project was to identify the genetic causes of diseases. The first human genome was sequenced about twenty years ago, and since then genome-wide association studies (GWAS) have identified genetic variants that correlate with many human traits, including disease and disease risk. Usually the GWAS variant affects the regulation of the closest gene or the activity of its protein product, but about 20–30% of the time the effect involves another gene that can be hundreds of kilobases away. We describe a new method, SigNet, to identify which gene within each GWAS locus is most likely to be causal. SigNet uses within-locus information when it is available, for example 'gold-standard' genes from family-based Mendelian studies, and adds between-locus information from protein-protein and gene-regulatory interaction networks to create a holistic model of causal genes across all loci. In applications to cardiovascular disease, we show better ability to identify relevant pathways and suggest new candidate genes within several GWAS loci. [ABSTRACT FROM AUTHOR]

Published
2025
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14. Genetics

Author

Arvanitis, Marios, Post, Wendy S., Battle, Alexis, and Martin, Seth S., editor

Published
2021
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18. A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels

Author

Gezonde Vaten, Circulatory Health, de Vries, Paul S., Reventun, Paula, Brown, Michael R., Heath, Adam S., Huffman, Jennifer E., Le, Ngoc Quynh, Bebo, Allison, Brody, Jennifer A., Temprano-Sagrera, Gerard, Raffield, Laura M., Ozel, Ayse Bilge, Thibord, Florian, Jain, Deepti, Lewis, Joshua P., Rodriguez, Benjamin A.T., Pankratz, Nathan, Taylor, Kent D., Polasek, Ozren, Chen, Ming Huei, Yanek, Lisa R., Carrasquilla, German D., Marioni, Riccardo E., Kleber, Marcus E., Trégouët, David Alexandre, Yao, Jie, Li-Gao, Ruifang, Joshi, Peter K., Trompet, Stella, Martinez-Perez, Angel, Ghanbari, Mohsen, Howard, Tom E., Reiner, Alex P., Arvanitis, Marios, Ryan, Kathleen A., Bartz, Traci M., Rudan, Igor, Faraday, Nauder, Linneberg, Allan, Ekunwe, Lynette, Davies, Gail, Delgado, Graciela E., Suchon, Pierre, Guo, Xiuqing, Rosendaal, Frits R., Klaric, Lucija, Noordam, Raymond, van Rooij, Frank, Curran, Joanne E., Wheeler, Marsha M., van der Harst, Pim, Trans-Omics for Precision Medicine (TOPMed) program, the INVENT consortium, Gezonde Vaten, Circulatory Health, de Vries, Paul S., Reventun, Paula, Brown, Michael R., Heath, Adam S., Huffman, Jennifer E., Le, Ngoc Quynh, Bebo, Allison, Brody, Jennifer A., Temprano-Sagrera, Gerard, Raffield, Laura M., Ozel, Ayse Bilge, Thibord, Florian, Jain, Deepti, Lewis, Joshua P., Rodriguez, Benjamin A.T., Pankratz, Nathan, Taylor, Kent D., Polasek, Ozren, Chen, Ming Huei, Yanek, Lisa R., Carrasquilla, German D., Marioni, Riccardo E., Kleber, Marcus E., Trégouët, David Alexandre, Yao, Jie, Li-Gao, Ruifang, Joshi, Peter K., Trompet, Stella, Martinez-Perez, Angel, Ghanbari, Mohsen, Howard, Tom E., Reiner, Alex P., Arvanitis, Marios, Ryan, Kathleen A., Bartz, Traci M., Rudan, Igor, Faraday, Nauder, Linneberg, Allan, Ekunwe, Lynette, Davies, Gail, Delgado, Graciela E., Suchon, Pierre, Guo, Xiuqing, Rosendaal, Frits R., Klaric, Lucija, Noordam, Raymond, van Rooij, Frank, Curran, Joanne E., Wheeler, Marsha M., van der Harst, Pim, Trans-Omics for Precision Medicine (TOPMed) program, and the INVENT consortium

Published
2024

19. A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels

Author

de Vries, Paul S., Reventun, Paula, Brown, Michael R., Heath, Adam S., Huffman, Jennifer E., Le, Ngoc Quynh, Bebo, Allison, Brody, Jennifer A., Temprano-Sagrera, Gerard, Raffield, Laura M., Ozel, Ayse Bilge, Thibord, Florian, Jain, Deepti, Lewis, Joshua P., Rodriguez, Benjamin A.T., Pankratz, Nathan, Taylor, Kent D., Polasek, Ozren, Chen, Ming Huei, Yanek, Lisa R., Carrasquilla, German D., Marioni, Riccardo E., Kleber, Marcus E., Trégouët, David Alexandre, Yao, Jie, Li-Gao, Ruifang, Joshi, Peter K., Trompet, Stella, Martinez-Perez, Angel, Ghanbari, Mohsen, Howard, Tom E., Reiner, Alex P., Arvanitis, Marios, Ryan, Kathleen A., Bartz, Traci M., Rudan, Igor, Faraday, Nauder, Linneberg, Allan, Ekunwe, Lynette, Davies, Gail, Delgado, Graciela E., Hansen, Torben, Chen, Wei Min, Jackson, Rebecca, Liu, Yu, Loos, Ruth J.F., Rao, D. C., Wang, Lu, Nielsen, Jonas B., Kilpeläinen, Tuomas O., de Vries, Paul S., Reventun, Paula, Brown, Michael R., Heath, Adam S., Huffman, Jennifer E., Le, Ngoc Quynh, Bebo, Allison, Brody, Jennifer A., Temprano-Sagrera, Gerard, Raffield, Laura M., Ozel, Ayse Bilge, Thibord, Florian, Jain, Deepti, Lewis, Joshua P., Rodriguez, Benjamin A.T., Pankratz, Nathan, Taylor, Kent D., Polasek, Ozren, Chen, Ming Huei, Yanek, Lisa R., Carrasquilla, German D., Marioni, Riccardo E., Kleber, Marcus E., Trégouët, David Alexandre, Yao, Jie, Li-Gao, Ruifang, Joshi, Peter K., Trompet, Stella, Martinez-Perez, Angel, Ghanbari, Mohsen, Howard, Tom E., Reiner, Alex P., Arvanitis, Marios, Ryan, Kathleen A., Bartz, Traci M., Rudan, Igor, Faraday, Nauder, Linneberg, Allan, Ekunwe, Lynette, Davies, Gail, Delgado, Graciela E., Hansen, Torben, Chen, Wei Min, Jackson, Rebecca, Liu, Yu, Loos, Ruth J.F., Rao, D. C., Wang, Lu, Nielsen, Jonas B., and Kilpeläinen, Tuomas O.

Abstract

Coagulation factor VIII (FVIII) and its carrier protein von Willebrand factor (VWF) are critical to coagulation and platelet aggregation. We leveraged whole-genome sequence data from the Trans-Omics for Precision Medicine (TOPMed) program along with TOPMed-based imputation of genotypes in additional samples to identify genetic associations with circulating FVIII and VWF levels in a single-variant meta-analysis, including up to 45 289 participants. Gene-based aggregate tests were implemented in TOPMed. We identified 3 candidate causal genes and tested their functional effect on FVIII release from human liver endothelial cells (HLECs) and VWF release from human umbilical vein endothelial cells. Mendelian randomization was also performed to provide evidence for causal associations of FVIII and VWF with thrombotic outcomes. We identified associations (P < 5 × 10−9) at 7 new loci for FVIII (ST3GAL4, CLEC4M, B3GNT2, ASGR1, F12, KNG1, and TREM1/NCR2) and 1 for VWF (B3GNT2). VWF, ABO, and STAB2 were associated with FVIII and VWF in gene-based analyses. Multiphenotype analysis of FVIII and VWF identified another 3 new loci, including PDIA3. Silencing of B3GNT2 and the previously reported CD36 gene decreased release of FVIII by HLECs, whereas silencing of B3GNT2, CD36, and PDIA3 decreased release of VWF by HVECs. Mendelian randomization supports causal association of higher FVIII and VWF with increased risk of thrombotic outcomes. Seven new loci were identified for FVIII and 1 for VWF, with evidence supporting causal associations of FVIII and VWF with thrombotic outcomes. B3GNT2, CD36, and PDIA3 modulate the release of FVIII and/or VWF in vitro., Coagulation factor VIII (FVIII) and its carrier protein von Willebrand factor (VWF) are critical to coagulation and platelet aggregation. We leveraged whole-genome sequence data from the Trans-Omics for Precision Medicine (TOPMed) program along with TOPMed-based imputation of genotypes in additional samples to identify genetic associations with circulating FVIII and VWF levels in a single-variant meta-analysis, including up to 45 289 participants. Gene-based aggregate tests were implemented in TOPMed. We identified 3 candidate causal genes and tested their functional effect on FVIII release from human liver endothelial cells (HLECs) and VWF release from human umbilical vein endothelial cells. Mendelian randomization was also performed to provide evidence for causal associations of FVIII and VWF with thrombotic outcomes. We identified associations (P < 5 × 10−9) at 7 new loci for FVIII (ST3GAL4, CLEC4M, B3GNT2, ASGR1, F12, KNG1, and TREM1/NCR2) and 1 for VWF (B3GNT2). VWF, ABO, and STAB2 were associated with FVIII and VWF in gene-based analyses. Multiphenotype analysis of FVIII and VWF identified another 3 new loci, including PDIA3. Silencing of B3GNT2 and the previously reported CD36 gene decreased release of FVIII by HLECs, whereas silencing of B3GNT2, CD36, and PDIA3 decreased release of VWF by HVECs. Mendelian randomization supports causal association of higher FVIII and VWF with increased risk of thrombotic outcomes. Seven new loci were identified for FVIII and 1 for VWF, with evidence supporting causal associations of FVIII and VWF with thrombotic outcomes. B3GNT2, CD36, and PDIA3 modulate the release of FVIII and/or VWF in vitro.

Published
2024

20. A genetic association study of circulating coagulation Factor VIII and von Willebrand Factor levels

Author

de Vries, Paul S., primary, Reventun, Paula, additional, Brown, Michael R, additional, Heath, Adam S, additional, Huffman, Jennifer E., additional, Le, Ngoc-Quynh, additional, Bebo, Allison, additional, Brody, Jennifer A, additional, Temprano-Sagrera, Gerard, additional, Raffield, Laura M, additional, Ozel, Ayse Bilge, additional, Thibord, Florian, additional, Jain, Deepti, additional, Lewis, Joshua P, additional, Rodriguez, Benjamin A.T., additional, Pankratz, Nathan, additional, Taylor, Kent D, additional, Polasek, Ozren, additional, Chen, Ming-Huei, additional, Yanek, Lisa R, additional, Carrasquilla, German, additional, Marioni, Riccardo, additional, Kleber, Marcus E, additional, Trégouët, David-Alexandre, additional, Yao, Jie, additional, Li-Gao, Ruifang, additional, Joshi, Peter K, additional, Trompet, Stella, additional, Martinez-Perez, Angel, additional, Ghanbari, Mohsen, additional, Howard, Tom E., additional, Reiner, Alex P, additional, Arvanitis, Marios, additional, Ryan, Kathleen A, additional, Bartz, Traci M, additional, Rudan, Igor, additional, Faraday, Nauder, additional, Linneberg, Allan, additional, Ekunwe, Lynette, additional, Davies, Gail, additional, Delgado, Graciela E, additional, Suchon, Pierre, additional, Guo, Xiuqing, additional, Rosendaal, Frits R., additional, Klaric, Lucija, additional, Noordam, Raymond, additional, van Rooij, Frank J.A., additional, Curran, Joanne, additional, Wheeler, Marsha Maria, additional, Osburn, William O, additional, O'Connell, Jeffrey R, additional, Boerwinkle, Eric, additional, Beswick, Andrew, additional, Psaty, Bruce M., additional, Kolcic, Ivana, additional, Souto, Juan Carlos Carlos, additional, Becker, Lewis, additional, Hansen, Torben, additional, Doyle, Margaret F., additional, Harris, Sarah, additional, Moissl, Angela Patricia, additional, Deleuze, Jean-François, additional, Rich, Stephen S, additional, van Hylckama Vlieg, Astrid, additional, Campbell, Harry, additional, Stott, David, additional, Soria, Jose Manuel, additional, de Maat, Moniek P.M., additional, Almasy, Laura, additional, Brody, Lawrence C., additional, Auer, Paul, additional, Mitchell, Braxton D, additional, Ben-Shlomo, Yoav, additional, Fornage, Myriam, additional, Hayward, Caroline, additional, Mathias, Rasika, additional, Kilpeläinen, Tuomas O, additional, Lange, Leslie, additional, Cox, Simon R, additional, Maerz, Winfried, additional, Morange, Pierre-Emmanuel, additional, Rotter, Jerome I, additional, Mook-Kanamori, Dennis O, additional, Wilson, James, additional, van der Harst, Pim, additional, Jukema, Johan Wouter W., additional, Ikram, Mohammad Arfan, additional, Blangero, John, additional, Kooperberg, Charles, additional, Desch, Karl, additional, Johnson, Andrew D., additional, Sabater-Lleal, Maria, additional, Lowenstein, Charles, additional, Smith, Nicholas L., additional, and Morrison, Alanna, additional

Published
2024
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21. Retinal transcriptome and eQTL analyses identify genes associated with age-related macular degeneration

Author

Ratnapriya, Rinki, Sosina, Olukayode A., Starostik, Margaret R., Kwicklis, Madeline, Kapphahn, Rebecca J., Fritsche, Lars G., Walton, Ashley, Arvanitis, Marios, Gieser, Linn, Pietraszkiewicz, Alexandra, Montezuma, Sandra R., Chew, Emily Y., Battle, Alexis, Abecasis, Gonçalo R., Ferrington, Deborah A., Chatterjee, Nilanjan, and Swaroop, Anand

Published
2019
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22. CD36 regulates factor VIII secretion from liver endothelial cells

Author

Dehghan, Abbas, Gill, Dipender, Elliot, Paul, Pankratz, Nathan, Tang, Weihong, Wei, Peng, deVries, Paul, Brown, Michael, Bressler, Jan, Hahn, Julie, Friedman, Rachel K., Heath, Adam, Morrison, Alanna, Strachan, David, Reiner, Alex P., Conomos, Matt, Psaty, Bruce M., Brody, Jen, Bis, Joshua C., Wiggins, Kerri L., Smith, Nicholas L., Hayward, Caroline, Richmond, Anne, O’Donnell, Chris, Huffman, Jenny, Chen, Ming-Huei, Yang, Qiong, Thibord, Florian, Liu, Melissa, Johnson, Andrew, Desch, Karl, Sabater-Lleal, Maria, Temprano, Gerard, Díez, Laia, Yanek, Lisa, Peyser, Patricia, Jhun, Mina, Wild, Philipp, Reiner, Alex, Raffield, Laura, Taylor, Herman, Nicholas, Jayna, Youkhana, Kim, Peters, Annette, Mueller, Martina, Ward-Caviness, Cavin, Koenig, Wolfgang, Cox, Simon, Davies, Gail, Marioni, Riccardo, Kleber, Marcus, Tregouet, David, Morange, Pierre, Rosendaal, Frits R., van Hylckama Vlieg, Astrid, Rotter, Jerry, Yao, Jie, Guo, Xiuqing, Damrauer, Scott, Li, Ruifang, Mook, Dennis, Campbell, Harry, van der Harst, Pim, Asselbergs, Folkert, Jukema, Wouter, Trompet, Stella, Kavousi, Maryam, Leebeek, Frank, de Maat, Moniek, Felix, Stephan, Voelker, Uwe, Homuth, Georg, Mangino, Massimo, Chasman, Daniel, Reventun, Paula, Toledano-Sanz, Pablo, Alcharani, Nunzio, Viskadourou, Maria, Morrison, Alanna C., Wolberg, Alisa S., de Vries, Paul S., Osburn, William O., Arvanitis, Marios, and Lowenstein, Charles J.

Published
2024
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29. CCRL2 affects the sensitivity of myelodysplastic syndrome and secondary acute myeloid leukemia cells to azacitidine

Author

Karantanos, Theodoros, primary, Teodorescu, Patric, additional, Arvanitis, Marios, additional, Perkins, Brandy, additional, Jain, Tania, additional, DeZern, Amy E., additional, Dalton, W. Brian, additional, Christodoulou, Ilias, additional, Paun, Bogdan C., additional, Varadhan, Ravi, additional, Esteb, Christopher, additional, Rajkhowa, Trivikram, additional, Bonifant, Challice, additional, Gondek, Lukasz P., additional, Levis, Mark J., additional, Yegnasubramanian, Srinivasan, additional, Ghiaur, Gabriel, additional, and Jones, Richard J., additional

Published
2022
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32. CD36 regulates factor VIII secretion from liver endothelial cells

Author

Reventun, Paula, Toledano-Sanz, Pablo, Alcharani, Nunzio, Viskadourou, Maria, Morrison, Alanna C., Sabater-Lleal, Maria, Wolberg, Alisa S., de Vries, Paul S., Smith, Nicholas L., Osburn, William O., Arvanitis, Marios, Lowenstein, Charles J., Dehghan, Abbas, Gill, Dipender, Elliot, Paul, Pankratz, Nathan, Tang, Weihong, Wei, Peng, deVries, Paul, Brown, Michael, Bressler, Jan, Hahn, Julie, Friedman, Rachel K., Heath, Adam, Morrison, Alanna, Strachan, David, Reiner, Alex P., Conomos, Matt, Psaty, Bruce M., Brody, Jen, Bis, Joshua C., Wiggins, Kerri L., Smith, Nicholas L., Hayward, Caroline, Richmond, Anne, O’Donnell, Chris, Huffman, Jenny, Chen, Ming-Huei, Yang, Qiong, Thibord, Florian, Liu, Melissa, Johnson, Andrew, Desch, Karl, Sabater-Lleal, Maria, Temprano, Gerard, Díez, Laia, Yanek, Lisa, Peyser, Patricia, Jhun, Mina, Wild, Philipp, Reiner, Alex, Raffield, Laura, Taylor, Herman, Nicholas, Jayna, Youkhana, Kim, Peters, Annette, Mueller, Martina, Ward-Caviness, Cavin, Koenig, Wolfgang, Cox, Simon, Davies, Gail, Marioni, Riccardo, Kleber, Marcus, Tregouet, David, Morange, Pierre, Rosendaal, Frits R., van Hylckama Vlieg, Astrid, Rotter, Jerry, Yao, Jie, Guo, Xiuqing, O’Donnell, Chris, Damrauer, Scott, Li, Ruifang, Mook, Dennis, Rosendaal, Frits R., Campbell, Harry, van der Harst, Pim, Asselbergs, Folkert, Sabater-Lleal, Maria, Jukema, Wouter, Trompet, Stella, Sabater-Lleal, Maria, Kavousi, Maryam, Leebeek, Frank, de Maat, Moniek, Felix, Stephan, Voelker, Uwe, Homuth, Georg, Mangino, Massimo, Reiner, Alex P., and Chasman, Daniel

Published
2024
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33. The functional impact of rare variation across the regulatory cascade

Author

Li, Taibo, primary, Ferraro, Nicole, additional, Strober, Benjamin J., additional, Aguet, Francois, additional, Kasela, Silva, additional, Arvanitis, Marios, additional, Ni, Bohan, additional, van de Wiel, Laurens, additional, Hershberg, Elliot, additional, Ardlie, Kristin, additional, Arking, Dan E., additional, Beer, Rebecca L., additional, Brody, Jennifer, additional, Blackwell, Thomas W, additional, Clish, Clary, additional, Gabriel, Stacey, additional, Gerszten, Robert, additional, Guo, Xiuqing, additional, Gupta, Namrata, additional, Johnson, W. Craig, additional, Lappalainen, Tuuli, additional, Lin, Henry J., additional, Liu, Yongmei, additional, Nickerson, Deborah A., additional, Papanicolaou, George, additional, Pritchard, Jonathan K., additional, Qasba, Pankaj, additional, Shojaie, Ali, additional, Smith, Josh, additional, Sotoodehnia, Nona, additional, Taylor, Kent D., additional, Tracy, Russell P., additional, Van Den Berg, David, additional, Wheeler, Matthew, additional, Rich, Stephen S., additional, Rotter, Jerome I., additional, Battle, Alexis, additional, and Montgomery, Stephen B., additional

Published
2022
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38. Author Correction: Retinal transcriptome and eQTL analyses identify genes associated with age-related macular degeneration

Author

Ratnapriya, Rinki, Sosina, Olukayode A., Starostik, Margaret R., Kwicklis, Madeline, Kapphahn, Rebecca J., Fritsche, Lars G., Walton, Ashley, Arvanitis, Marios, Gieser, Linn, Pietraszkiewicz, Alexandra, Montezuma, Sandra R., Chew, Emily Y., Battle, Alexis, Abecasis, Gonçalo R., Ferrington, Deborah A., Chatterjee, Nilanjan, and Swaroop, Anand

Published
2019
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40. Abstract 5435: CCRL2 affects the sensitivity of MDS and secondary AML to azacitidine

Author

Karantanos, Theodoros, primary, Teodorescu, Patric, additional, Perkins, Brandy, additional, Arvanitis, Marios, additional, Christodolou, Ilias, additional, Esteb, Christopher, additional, Dalton, W. Brian, additional, Jain, Tania, additional, DeZern, Amy E., additional, Gondek, Lukasz P., additional, Levis, Mark J., additional, Ghiaur, Gabriel, additional, and Jones, Richard J., additional

Published
2022
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48. ACE inhibition and cardiometabolic risk factors, lungACE2andTMPRSS2gene expression, and plasma ACE2 levels: a Mendelian randomization study

Author

Gill, Dipender, primary, Arvanitis, Marios, additional, Carter, Paul, additional, Hernández Cordero, Ana I., additional, Jo, Brian, additional, Karhunen, Ville, additional, Larsson, Susanna C., additional, Li, Xuan, additional, Lockhart, Sam M., additional, Mason, Amy, additional, Pashos, Evanthia, additional, Saha, Ashis, additional, Tan, Vanessa Y., additional, Zuber, Verena, additional, Bossé, Yohan, additional, Fahle, Sarah, additional, Hao, Ke, additional, Jiang, Tao, additional, Joubert, Philippe, additional, Lunt, Alan C., additional, Ouwehand, Willem Hendrik, additional, Roberts, David J., additional, Timens, Wim, additional, van den Berge, Maarten, additional, Watkins, Nicholas A., additional, Battle, Alexis, additional, Butterworth, Adam S., additional, Danesh, John, additional, Di Angelantonio, Emanuele, additional, Engelhardt, Barbara E., additional, Peters, James E., additional, Sin, Don D., additional, and Burgess, Stephen, additional

Published
2020
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