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135 results on '"Asaad, Imad"'

9. S1588 Prevalence and Risk Factors Associated With Non-Alcoholic Steatohepatitis in Patients With Helicobacter pylori Infection: A Population-Based Study

Author

Onwuzo, Somtochukwu, primary, Boustany, Antoine, additional, Ibrahim, Mounir, additional, Abuassi, Mohammad, additional, Gharaibeh, Eyad Z., additional, El Alayli, Abdallah, additional, Qapaja, Thabet, additional, Onwuzo, Chidera, additional, Almomani, Ashraf, additional, and Asaad, Imad, additional

Published
2023
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10. The Prevalence of Nonalcoholic Steatohepatitis (NASH)-Related Advanced Fibrosis and Cirrhosis in the United States Population Utilizing AGILE 3+ and AGILE 4+ Scores: Analysis of the NHANES 2017-2018 Cycle

Author

Alkhouri, Naim, primary, Almomani, Ashraf, additional, Le, Phuc, additional, Payne, Julia Y., additional, Asaad, Imad, additional, Polanco, Prido, additional, Leff, Phillip, additional, Kumar, Prabhat, additional, and Noureddin, Mazen, additional

Published
2023
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21. Prevalence and Risk Factors Associated With Inflammatory Bowel Disease in Patients Using Proton-Pump Inhibitors: A Population-Based Study

Author

Onwuzo, Somtochukwu, primary, Boustany, Antoine, additional, Khaled Abou Zeid, Hadi, additional, Hitawala, Asif, additional, Almomani, Ashraf, additional, Onwuzo, Chidera, additional, Lawrence, Favour, additional, Mascarenhas Monteiro, Jessy, additional, Ndubueze, Chidera, additional, and Asaad, Imad, additional

Published
2023
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24. Epidemiology and prevalence of lean nonalcoholic fatty liver disease and associated cirrhosis, hepatocellular carcinoma, and cardiovascular outcomes in the United States: a population‐based study and review of literature

Author

Almomani, Ashraf, primary, Kumar, Prabhat, additional, Onwuzo, Somtochukwu, additional, Boustany, Antoine, additional, Krishtopaytis, Eduard, additional, Hitawala, Asif, additional, Alshaikh, Dana, additional, Albakri, Almaza, additional, Hussein, Leen, additional, Hussein, Ebrahim, additional, and Asaad, Imad, additional

Published
2022
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26. S1338 The Prevalence of Protein-Calorie Malnutrition Among Patients With Alcoholic, Non-Alcoholic and Chronic Viral Cirrhosis in the United States: A Population-Based Study

Author

Boustany, Antoine, primary, Onwuzo, Somtochukwu, additional, Almomani, Ashraf, additional, Kumar, Prabhat, additional, Krishtopaytis, Eduard, additional, Albakri, Almaza A., additional, Hitawala, Asif, additional, Alshaikh, Dana, additional, Alkhayyat, Motasem, additional, Alchirazi, Khaled Alsabbagh, additional, and Asaad, Imad, additional

Published
2022
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27. S666 Proton Pump Inhibitors Are Associated With a Higher Risk of Spontaneous Bacterial Peritonitis Independently of Gastrointestinal Bleeding: A Population-Based Study

Author

Boustany, Antoine, primary, Onwuzo, Somtochukwu, additional, Almomani, Ashraf, additional, Kumar, Prabhat, additional, Krishtopaytis, Eduard, additional, Albakri, Almaza A., additional, Hitawala, Asif, additional, Alshaikh, Dana, additional, Alkhayyat, Motasem, additional, Alchirazi, Khaled Alsabbagh, additional, Abu-Shawer, Osama, additional, and Asaad, Imad, additional

Published
2022
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33. 88: EPIDEMIOLOGY AND PREVALENCE OF LEAN NON-ALCOHOLIC FATTY LIVER DISEASE AND ASSOCIATED CIRRHOSIS IN THE UNITED STATES: A POPULATION-BASED STUDY

Author

Almomani, Ashraf, primary, Albakri, Almaza asif, additional, Alkhayyat, Motasem, additional, Onwuzo, Somtochukwu, additional, Krishtopaytis, Eduard, additional, Boustany, Antoine, additional, Kumar, Prabhat, additional, Alshaikh, Dana, additional, Hitawala, Asif Ali, additional, and Asaad, Imad, additional

Published
2022
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35. Cirrhotic patients on proton pump inhibitors are at a twofold risk of spontaneous bacterial peritonitis independently of gastrointestinal bleeding: a population-based retrospective study.

Author

Boustany, Antoine, Rahhal, Romy, Onwuzo, Somtochukwu, Almomani, Ashraf, Boustany, Tara, Kumar, Prabhat, hitawala, Asif, and Asaad, Imad

Subjects
PROTON pump inhibitors, GASTROINTESTINAL hemorrhage, PERITONITIS, HEPATIC encephalopathy
Abstract

Background Recent findings suggest that cirrhotic patients on proton pump inhibitors (PPIs) are at a higher risk for developing spontaneous bacterial peritonitis (SBP) than non-PPI users. We aimed to identify whether PPI use is an independent risk factor for the development of SBP among cirrhotic patients in the United States (US). Methods We enrolled a retrospective cohort using a validated multicenter database. Patients with a SNOMED-CT diagnosis of "cirrhosis" between 1999 and 2022 were identified. All patients below 18 years of age were excluded. We calculated the prevalence of individuals using PPIs in the total US population and in cirrhotic patients from 1999 to date, and the incidence of SBP in the past year. Finally, we constructed a multivariate regression model, controlling for multiple covariates. Results The final analysis included 377,420 patients. The 20-year-period prevalence of SBP in patients with cirrhosis was 3.54% and the prevalence of patients using PPIs in the US population was 12,000 per 100,000 people (12.00%). The 1-year incidence of SBP in cirrhotic patients using PPIs was 2500 per 100,000 people. After accounting for confounders, the risk of SBP was higher among males, patients with a diagnosis of gastrointestinal bleeding, and those using ß-blockers and PPIs. Conclusions To date, this is the largest cohort used to examine the prevalence of SBP among cirrhotic patients in the US. PPI use and hepatic encephalopathy offered the highest risk for the development of SBP, independently of gastrointestinal bleeding. Focusing on judicious PPI use should be encouraged among cirrhotic patients. [ABSTRACT FROM AUTHOR]

Published
2023
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37. Epidemiology and risk of colorectal cancer in patients with a history of Helicobacter pylori infection: a population-based study.

Author

Boustany, Antoine, Onwuzo, Somtochukwu, Almomani, Ashraf, and Asaad, Imad

Subjects
HELICOBACTER pylori infections, COLORECTAL cancer, DISEASE risk factors, INFLAMMATORY bowel diseases, IRRITABLE colon, TYPE 2 diabetes
Abstract

Background Numerous modifiable risk factors have been associated with colon cancer. Helicobacter pylori (H. pylori) is the most common bacterial infection worldwide and the strongest known risk factor for gastric cancer. We aim to assess whether the risk of colorectal cancer (CRC) is higher in patients with a history of H. pylori infection. Methods A validated multicenter and research platform database of more than 360 hospitals was queried. Patients aged 18-65 years were included in our cohort. We excluded all patients who had previously had a diagnosis of inflammatory bowel disease or celiac disease. Univariate and multivariate regression analyses were used to calculate CRC risk. Results A total of 47,714,750 patients were selected after application of the inclusion and exclusion criteria. The 20-year-period prevalence rate of CRC in the United States population from 1999 to September 2022 was 370 of 100,000 individuals (0.37%). According to multivariate analysis, the risk of CRC was higher in smokers (odds ratio [OR] 2.52, 95% confidence interval [CI] 2.47-2.57), obese patients (OR 2.26, 95%CI 2.22-2.30), those with irritable bowel syndrome (OR 2.02, 95%CI 1.94-2.09), or type 2 diabetes mellitus (OR 2.89, 95%CI 2.84-2.95), and patients who had a diagnosis of H. pylori infection (OR 1.89, 95%CI 1.69-2.10). Conclusion We provide the first evidence from a large population-based study demonstrating an independent association between a history of H. pylori infection and CRC risk. [ABSTRACT FROM AUTHOR]

Published
2023
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38. Epidemiology and prevalence of lean nonalcoholic fatty liver disease and associated cirrhosis, hepatocellular carcinoma, and cardiovascular outcomes in the United States: a population‐based study and review of literature.

Author

Almomani, Ashraf, Kumar, Prabhat, Onwuzo, Somtochukwu, Boustany, Antoine, Krishtopaytis, Eduard, Hitawala, Asif, Alshaikh, Dana, Albakri, Almaza, Hussein, Leen, Hussein, Ebrahim, and Asaad, Imad

Subjects
NON-alcoholic fatty liver disease, FATTY liver, DISEASE complications, HEPATOCELLULAR carcinoma, ALPHA 1-antitrypsin deficiency, HEPATOLENTICULAR degeneration
Abstract

Backgrounds: Nonalcoholic fatty liver disease (NAFLD) is linked to obesity and metabolic syndrome conditions. However, a subset of NAFLD patients express a normal or low body mass index (lean NAFLD [L‐NAFLD]). Our aim is to compare the prevalence of L‐NAFLD to the obesity‐associated NAFLD in the United States by assessing prevalence, potential risk factors, liver‐related complications, and coronary artery disease outcomes. Methodology: A multicenter database (Explorys Inc.) of >70 million patients across the United States was screened. A cohort of patients with "nonalcoholic fatty liver" between 1999 and 2021 was identified. Two sub‐cohorts of NAFLD patients were identified: those with a body mass index (BMI) < 25 kg/m2 (L‐NAFLD) and those with a BMI > 30 kg/m2 (obesity‐associated NAFLD). We excluded patients with age <18 and those who have viral hepatitis, hemochromatosis, Wilson's disease, biliary cirrhosis, alcoholic liver disease, cystic fibrosis, alpha‐1‐antitrypsin deficiency, and autoimmune hepatitis. Multivariate analysis was performed to adjust for confounders. Results: 68 892 260 individuals were screened. NAFLD prevalence was four per 100 000, and L‐NAFLD prevalence was 0.6 per 100 000. Compared with those without, patients with L‐NAFLD tended to be older (OR 2.16), females (OR 1.28), and smokers (OR 4.67) and of Asian race (OR 2.12). L‐NAFLD patients were more likely to have acute coronary syndromes (OR 30.00) and metabolic syndrome (OR 2.31) despite the normal/low BMI. Esophageal varices and hepatocellular carcinoma risks were high in both cirrhosis patients. Conclusion: This is the largest study to assess L‐NAFLD prevalence in the United States. L‐NAFLD are at a significantly higher risk for acute coronary syndromes, esophageal varices, and hepatocellular carcinoma. [ABSTRACT FROM AUTHOR]

Published
2023
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