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Conventional concrete causes significant environmental problems, including resource depletion, high CO2 emissions, and high energy consumption. Steel slag aggregate (SSA), a by-product of the steelmaking industry, offers a sustainable alternative due to its environmental benefits and improved mechanical properties. This study examined the predictive power of four modeling techniques—Gene Expression Programming (GEP), an Artificial Neural Network (ANN), Random Forest Regression (RFR), and Gradient Boosting (GB)—to predict the compressive strength (CS) of SSA concrete. Using 367 datasets from the literature, six input variables (cement, water, granulated furnace slag, superplasticizer, coarse aggregate, fine aggregate, and age) were utilized to predict compressive strength. The models’ performance was evaluated using statistical measures such as the mean absolute error (MAE), root mean squared error (RMSE), mean values, and coefficient of determination (R2). Results indicated that the GB model consistently outperformed RFR, GEP, and the ANN, achieving the highest R2 values of 0.99 and 0.96 for the training and testing dataset, respectively, followed by RFR with R2 values of 0.97 (training) and 0.93 (testing), GEP with R2 values of 0.85 (training) and 0.87 (testing), and ANN with R2 values of 0.61 (training) and 0.82 (testing). Additionally, the GB model had the lowest MAE values of 0.79 MPa (training) and 2.61 MPa (testing) and RMSE values of 1.90 MPa (training) and 3.95 MPa (testing). This research aims to advance predictive modeling in sustainable construction through analysis and well-defined conclusions.

Background Idiopathic intracranial hypertension (IIH) is prevalent among the US population, with exacerbation of symptoms during pregnancy. Transverse sinus stenting is a new effective treatment for IIH. Stenting is avoided in pregnancy largely due to the requirement of dual antiplatelet therapy. Methods We present a case of a pregnant patient in her first trimester with signs and symptoms of fulminant IIH, including progressive visual loss, who underwent placement of a transverse sinus stent and administration of dual antiplatelet therapy with ticagrelor. Results Ticagrelor was administered pre–operatively. The patient underwent venous sinus stenting for fulminant IIH. There were no complications. She had resolution of symptoms and underwent cesarean delivery without issues. Her child displayed no signs and symptoms of abnormalities. Conclusion Venous sinus stenting for IIH can be considered in pregnant patients presenting with new or worsening IIH with associated papilledema. The use of ticagrelor did not lead to any adverse outcomes for the patient or the fetus in our case.

Background and Objectives: Odontoidectomy is a surgical procedure indicated in the setting of various pathologies, with the main goal of decompressing the ventral brain stem and spinal cord as a result of irreducible compression at the craniovertebral junction. The endoscopic endonasal approach has been increasingly used as an alternative to the transoral approach as it provides a straightforward, panoramic, and direct approach to the odontoid process. In addition, intraoperative ultrasound (US) guidance is a technique that can optimize safety and surgical outcomes in this context. It is used as an adjunct to neuronavigation and provides intraoperative confirmation of decompression of craniovertebral junction structures in real time. The authors aim to present the use and safe application of real-time intraoperative US guidance during endonasal endoscopic resection of a retro-odontoid pannus. Methods: A retrospective chart review of a single case was performed and presented herein as a case report and narrated operative video. Results: A minimally invasive US transducer was used intraoperatively to guide the resection of a retro-odontoid pannus and confirm spinal cord decompression in real time. Postoperative examination of the patient revealed immediate neurological improvement. Conclusions: Intraoperative ultrasonography is a well described and useful modality in neurosurgery. However, the use of intraoperative US guidance during endonasal endoscopic approaches to the craniovertebral junction has not been previously described. As demonstrated in this technical note, the authors show that this imaging modality can be added to the ever-evolving armamentarium of neurosurgeons to safely guide the decompression of neural structures within the craniocervical junction with good surgical outcomes.

Ischemic stroke is a devastating health problem, affecting approximately 800,000 patients in the US every year, making it the leading cause of combined death and disability in the country. Stroke has historically been thought of as predominantly impacting men, however it is becoming increasingly clear that stroke affects women to a greater degree than men. Indeed, women have worse outcomes compared to men following ischemic stroke. Recent clinical advances have shown great promise in acute stroke therapy, with the use of mechanical endovascular thrombectomy (with and without recombinant tissue plasminogen activator; rtPA) greatly improving outcomes. This observation makes it clear that removal of clots and reperfusion, either mechanically or pharmacologically, is critical for improving outcomes of patients following acute ischemic stroke. Despite these promising advances, long-term neurological sequelae persist in the post-stroke population. This review focuses on mechanisms of thrombosis (clot formation) as it pertains to stroke and important sex differences in thrombosis and responses to treatment. Finally, we describe recent data related to new therapeutic approaches to thrombolysis, with a particular focus on von Willebrand Factor (vWF).

Background Radial artery spasm is a common hinderance during transradial approaches for neuroangiography. Ways of alleviation have been described, including patient sedation, local lidocaine, or even prophylactic administration of intra‐arterial vasodilators. Methods We present a case of a wedged catheter attributable to radial artery spasm, which failed all conventional methods to relieve spasm. Results The catheter was ultimately removed after administration of sublingual nitroglycerin. Conclusion To our knowledge, this is the first time sublingual nitrogen has been reported as an effective means to alleviate radial artery spasm during a transradial approach for neuroangiography.

Abstract Background Malaria is a major public health problem in India. Data from surveys totaling 3031 participants at three sites revealed a high proportion of asymptomatic infections, complicating diagnosis. The aim of this study was to identify differences in complaints and symptoms between sites, and factors associated with asymptomatic Plasmodium infections. Methods Published data from community-based cross-sectional studies conducted between 2012 and 2015 in Nadiad (Gujarat), Chennai (Tamil Nadu), and Rourkela (Odisha) as part of the Center for the Study of Complex Malaria in India were analysed. Complaints and symptoms were systematically recorded, and Plasmodium infections confirmed using microscopy, rapid diagnostic tests (RDTs), and polymerase chain reaction (PCR). Multivariate analyses were conducted to determine the association between general symptoms and age, season, or gender, and factors associated with asymptomatic Plasmodium infections were assessed. Results Complaints of any illness were lowest in Chennai (17.7%), 30.6% in Rourkela and 42.7% in Nadiad. Complaints were more often reported for children; gender differences were noted in Rourkela only. In Nadiad, 7.0% of 796 participants were positive for malaria by PCR (32% Plasmodium falciparum); 78.6% had a history of fever or documented fever, 14.3% had other symptoms, and 7.1% were “truly asymptomatic”. For Chennai this was 29.2%, 4.2% and 66.7% respectively, with a malaria prevalence of 2.6% by PCR of 928 participants (29% P. falciparum). In Rourkela, with 7.7% of 1307 participants positive for malaria by PCR (82% P. falciparum), the percentages were 35.6%, 24.8% and 39.6%, respectively. In Rourkela, asymptomatic infections were associated with young age and male gender (microscopy or RDT), and with rainy season (PCR). In the same site, participants with Plasmodium vivax were more likely to be asymptomatic (11/18 or 61.1%) than persons with P. falciparum mono-infections (27/78 or 34.6%); gametocytes for P. falciparum were evenly distributed between symptomatic and asymptomatic infections (2/53 vs. 2/49, respectively). The addition of the symptoms “headache”, “aches” and “chills” to fever improved the case-definition of symptomatic malaria. Conclusion There were considerable differences in complaints at the three sites in India. Malaria and asymptomatic infections differ by region, indicating that malaria elimination will require localized approaches.

Pyrolysis based biorefineries have great potential to convert waste such as plastic and biomass waste into energy and other valuable products, to achieve maximum economic and environmental benefits. In this study, the catalytic pyrolysis of different types of plastics wastes (PS, PE, PP, and PET) as single or mixed in different ratios, in the presence of modified natural zeolite (NZ) catalysts, in a small pilot scale pyrolysis reactor was carried out. The NZ was modified by thermal activation (TA-NZ) at 550°C and acid activation (AA-NZ) with HNO3, to enhance its catalytic properties. The catalytic pyrolysis of PS produced a higher liquid oil (70 and 60%) than PP (40 and 54%) and PE (40 and 42%), using TA-NZ and AA-NZ catalysts, respectively. The gas chromatography-mass spectrometry (GC-MS) analysis of oil showed a mixture of aromatics, aliphatic and other hydrocarbon compounds. The TA-NZ and AA-NZ catalysts showed a different effect on the wt% of catalytic pyrolysis products and liquid oil chemical compositions, with AA-NZ showing higher catalytic activity than TA-NZ. FT-IR results showed clear peaks of aromatic compounds in all liquid oil samples with some peaks of alkanes that further confirmed the GC-MS results. The liquid oil has a high heating value (HHV) range of 41.7–44.2 MJ/kg, close to conventional diesel. Therefore, it has the potential to be used as an alternative source of energy and as transportation fuel after refining/blending with conventional fuels.

Freshwater scarcity and other abiotic factors, such as climate and soil salinity in the Near East and North Africa (NENA) region, are affecting crop production. Therefore, farmers are looking for salt-tolerant crops that can successfully be grown in these harsh environments using poor-quality groundwater. Barley is the main staple food crop for most of the countries of this region, including Tunisia. In this study, the AquaCrop model with a salinity module was used to evaluate the performance of two barley varieties contrasted for their resistance to salinity in three contrasted agro-climatic areas in Tunisia. These zones represent sub-humid, semi-arid, and arid climates. The model was calibrated and evaluated using field data collected from two cropping seasons (2012–14), then the calibrated model was used to develop different scenarios under irrigation with saline water from 5, 10 to 15 dS m−1. The scenario results indicate that biomass and yield were reduced by 40% and 27% in the semi-arid region (KAI) by increasing the irrigation water salinity from 5 to 15 dS m−1, respectively. For the salt-sensitive variety, the reductions in biomass and grain yield were about 70%, respectively, although overall biomass and yield in the arid region (MED) were lower than in the KAI area, mainly with increasing salinity levels. Under the same environmental conditions, biomass and yield reductions for the salt-tolerant barley variety were only 16% and 8%. For the salt-sensitive variety, the biomass and grain yield reductions in the MED area were about 12% and 43%, respectively, with a similar increase in the salinity levels. Similar trends were visible in water productivities. Interestingly, biomass, grain yield, and water productivity values for both barley varieties were comparable in the sub-humid region (BEJ) that does not suffer from salt stress. However, the results confirm the interest of cultivating a variety tolerant to salinity in environments subjected to salt stress. Therefore, farmers can grow both varieties in the rainfed of BEJ; however, in KAI and MED areas where irrigation is necessary for crop growth, the salt-tolerant barley variety should be preferred. Indeed, the water cost will be reduced by 49% through growing a tolerant variety irrigated with saline water of 15 dS m−1.

Transfer RNA (tRNA) plays a central role in protein synthesis and acts as an adaptor molecule between an mRNA and an amino acid. A tRNA has an L-shaped clover leaf-like structure and contains an acceptor arm, D-arm, D-loop, anti-codon arm, anti-codon loop, variable loop, Ψ-arm and Ψ-loop. All of these arms and loops are important in protein translation. Here, we aimed to delineate the genomic architecture of these arms and loops in cyanobacterial tRNA. Studies from tRNA sequences from 61 cyanobacterial species showed that, except for few tRNAs (tRNAAsn, tRNALeu, tRNAGln, and tRNAMet), all contained a G nucleotide at the 1st position in the acceptor arm. tRNALeu and tRNAMet did not contain any conserved nucleotides at the 1st position whereas tRNAAsn and tRNAGln contained a conserved U1 nucleotide. In several tRNA families, the variable region also contained conserved nucleotides. Except for tRNAMet and tRNAGlu, all other tRNAs contained a conserved A nucleotide at the 1st position in the D-loop. The Ψ-loop contained a conserved U1-U2-C3-x-A5-x-U7 sequence, except for tRNAGly, tRNAAla, tRNAVal, tRNAPhe, tRNAThr, and tRNAGln in which the U7 nucleotide was not conserved. However, in tRNAAsp, the U7 nucleotide was substituted with a C7 nucleotide. Additionally, tRNAArg, tRNAGly, and tRNALys of cyanobacteria contained a group I intron within the anti-codon loop region. Maximum composite likelihood study on the transition/transversion of cyanobacterial tRNA revealed that the rate of transition was higher than the rate of transversion. An evolutionary tree was constructed to understand the evolution of cyanobacterial tRNA and analyses revealed that cyanobacterial tRNA may have evolved polyphyletically with high rate of gene loss.

This research characterizes the performance of various plant-produced asphalt concrete mixtures by dynamic modulus |E∗| test using asphalt mixture performance tester (AMPT). Marshall designed specimens of seven different mixtures were prepared using the Superpave gyratory compactor and subjected to sinusoidal compressive loading at various temperatures (4.4 to 54.4°C) and loading frequencies (0.1 to 25 Hz). A catalog of default dynamic modulus values for typical asphalt concrete mixtures of Pakistan was established by developing stress-dependent master curves separately, for wearing and base course mixtures. The sensitivity of temperature and loading frequency on determination of dynamic modulus value was observed by typical isothermal and isochronal curves, respectively. Also, the effects of various variables on dynamic modulus were investigated using statistical technique of two-level factorial design of experiment. Furthermore, two dynamic modulus prediction models, namely, Witczak and Hirsch, were evaluated for their regional applicability. Results indicated that both the Witczak and Hirsch models mostly underpredict the value of dynamic modulus for the selected conditions/mixtures. The findings of this study are envisaged to facilitate the implementation of relatively new performance based mechanistic-empirical structural design and analysis approach.

ABSTRACT Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel betacoronavirus that has been circulating in the Arabian Peninsula since 2012 and causing severe respiratory infections in humans. While bats were suggested to be involved in human MERS-CoV infections, a direct link between bats and MERS-CoV is uncertain. On the other hand, serological and virological data suggest dromedary camels as the potential animal reservoirs of MERS-CoV. Recently, we isolated MERS-CoV from a camel and its infected owner and provided evidence for the direct transmission of MERS-CoV from the infected camel to the patient. Here, we extend this work and show that identical MERS-CoV RNA fragments were detected in an air sample collected from the same barn that sheltered the infected camel in our previous study. These data indicate that the virus was circulating in this farm concurrently with its detection in the camel and in the patient, which warrants further investigations for the possible airborne transmission of MERS-CoV. IMPORTANCE This work clearly highlights the importance of continuous surveillance and infection control measures to control the global public threat of MERS-CoV. While current MERS-CoV transmission appears to be limited, we advise minimal contact with camels, especially for immunocompromised individuals, and the use of appropriate health, safety, and infection prevention and control measures when dealing with infected patients. Also, detailed clinical histories of any MERS-CoV cases with epidemiological and laboratory investigations carried out for any animal exposure must be considered to identify any animal source.

Cross-laminated timber (CLT) is an engineered timber composite that is finding increasing structural application in construction today. Analysis of the structural behavior of CLT can be carried out by various analytical and numerical methods. Due to the complex behavior of CLT, use of numerical modelling such as the finite element method (FEM) offers a convenient approach to analysis. In this paper, simulation of the elastic behavior of 1-way and 2-way spanning CLT panels using the FEM program ABAQUS is presented. Various modelling choices are explored numerically with the results being evaluated against those from either a 3D analytical method known as the state space approach (SSA) or existing experimental data. Among the case studies examined is a novel boundary condition for the SSA solution. In general, the optimum finite element model produced reasonable levels of accuracy with an average relative error equal to 3% in comparison to the SSA and a maximum of 10% in comparison to the experimental results. Key words: cross-laminated timber, finite element method, analytical solution, state space approach. Le bois lamelle-croise (BLC) est un composite de bois d'ingenierie qui desormais sert de plus en plus a la construction. L'analyse du comportement structurel du BLC peut etre effectuee par diverses methodes analytiques et numeriques. En raison du comportement complexe du BLC, l'utilisation de la modelisation numerique telle que la methode des elements finis (MEF) offre une approche pratique de l'analyse. Dans cet article, la simulation du comportement elastique des panneaux en BLC a une et deux directions utilisant le programme FEM ABAQUS est presentee. Divers choix de modelisation sont explores numeriquement et les resultats sont evalues par rapport a ceux d'une methode d'analyse tridimensionnelle (3D) connue sous le nom d'approche de l'espace des etats (AEE) ou de donnees experimentales existantes. Parmi les etudes de cas examinees, il y a une nouvelle condition limite pour la solution d'AEE En general, le modele optimal d'elements finis a produit des niveaux raisonnables de precision avec une erreur relative moyenne egale a 3% par rapport a l'AEU et un maximum de 10% par rapport aux resultats experimentaux. [Traduit par la Redaction] Mots-cles : bois lamelle-croise, methode des elements finis, solution analytique, approche de l'espace des etats., 1. Cross-laminated timber (CLT): background and characteristics CLT is a laminated timber composite that can be used to form structural elements including walls, floor plates, and roofs etc. It was [...]

Conventional concrete causes significant environmental problems, including resource depletion, high CO2 emissions, and high energy consumption. Steel slag aggregate (SSA), a by-product of the steelmaking industry, offers a sustainable alternative due to its environmental benefits and improved mechanical properties. This study examined the predictive power of four modeling techniques—Gene Expression Programming (GEP), an Artificial Neural Network (ANN), Random Forest Regression (RFR), and Gradient Boosting (GB)—to predict the compressive strength (CS) of SSA concrete. Using 367 datasets from the literature, six input variables (cement, water, granulated furnace slag, superplasticizer, coarse aggregate, fine aggregate, and age) were utilized to predict compressive strength. The models' performance was evaluated using statistical measures such as the mean absolute error (MAE), root mean squared error (RMSE), mean values, and coefficient of determination (R2). Results indicated that the GB model consistently outperformed RFR, GEP, and the ANN, achieving the highest R2 values of 0.99 and 0.96 for the training and testing dataset, respectively, followed by RFR with R2 values of 0.97 (training) and 0.93 (testing), GEP with R2 values of 0.85 (training) and 0.87 (testing), and ANN with R2 values of 0.61 (training) and 0.82 (testing). Additionally, the GB model had the lowest MAE values of 0.79 MPa (training) and 2.61 MPa (testing) and RMSE values of 1.90 MPa (training) and 3.95 MPa (testing). This research aims to advance predictive modeling in sustainable construction through analysis and well-defined conclusions. [ABSTRACT FROM AUTHOR]

This study emphasized the alpha-amylase gene from Bacillus licheniformis as this species has been witnessed as the most prolific bio-factories for the alpha amylase production on industrial scales with particular reference to its wide commercial applicability. In the present study, a gene encoding alpha-amylase from an indigenously isolated B. licheniformis 208 strain was PCR amplified and sequenced. The obtained 1313 bp long nucleotide sequence (GenBank KM27230) exhibited the closest match with its homologous genes in B. licheniformis ATCC 9945A and ATCC 14580 strains. Gene translation retrieved 437 amino acid long enzyme sequence and exhibits a molecular weight of 50231.8 KDa. Other computed parameters include isoelectric point (5.95), aliphatic index (67.4), instability index (27.45), and GRAVY (-0.627) values. The structure of alphaamylase 208 was found to exhibit a 17 residues long active site, a conserved catalytic site with 3 residues, and a ligand-binding site comprised of 3 residues. Secondary structure configuration in the alpha-amylase 208 was predominated with a-helix and random coils followed by extended strands. The number of ß-turns was found comparatively less. ITASSER assigned E.C number to the BLA 208 sequence was 3.2.1.1 with extracellular origin. Deduced tertiary structure of BLA 208 showed the 7 residues long active site comprising of histidine, arginine, aspartic acid, glutamic acid, tryptophan, histidine, and aspartic acid at position 122, 246, 248, 278, 280, 344, 345 respectively. Na, K, and Ca were observed as the ligand-binding sites existing as a metal triad. Natural selection analysis explains that the alpha-amylase gene in B. licheniformis species is under purifying or negative selection i.e. it stabilizes itself by removing the deleterious mutation. Recombination event analysis was done using GARD (Genetic algorithm for recombination detection). Although, it rather inferred the presence of two break points which were found insignificant when validated via Kishino-Hasegawa test which demonstrates topological incongruence. [ABSTRACT FROM AUTHOR]

Abstract By employing a synergistic blend of experimental and theoretical methodologies, we investigated the corrosion inhibition efficacy of a synthesized pyrazole derivative (BM-01) in a solution of hydrochloric acid (1 M). We utilized molecular dynamics (MD) simulations, scanning electron microscopy (SEM), density functional theory (DFT), complexation, plus electrochemical impedance spectroscopy (EIS). We conducted weight loss (WL) measurements from 298 to 328 K. Inhibition efficacy reached a maximum at a BM-01 concentration of 10−3 M, achieving 90.0% (EIS), 90.40% (WL), and 90.38% (potentiodynamic polarization (PDP)). SEM unveiled the shielding of the carbon-steel surface from acid-induced damage by BM-01. The Langmuir adsorption isotherm exhibited a robust fit with a low sum of squares, standard deviation, and a high correlation coefficient. PDP findings indicated that BM-01 acted as a mixed-type inhibitor, predominantly favoring the cathodic process, suggesting potential corrosion-mitigation properties. Theoretical analyses involving DFT, MD simulations, and radial distribution function were conducted to postulate a mechanism and identify an inhibitory layer. Theoretical outcomes aligned closely with experimental data, thereby reinforcing the validity of our findings.

This study assessed the potential of a commercial probiotic mixture on performance, gut health and nutrient utilisation of broilers-fed poultry by-product meal (PBM)-based diet. Three-hundred-and-twenty Ross-308-day-old broiler chicks were obtained from a commercial poultry hatchery. The chicks were randomly assigned to four different treatment groups, each consisting of four replicates (n = 10) in a randomised complete design. The positive control group (CON) was fed commercial poultry ration, and the negative control group (N-CON) was fed PBM partially replacing soybean meal at a 65% level. The MSP1 and MSP2 groups contained the same diet as the N-CON group but supplemented with multi-strain probiotics (MSP) at 50 mg/kg and 100 mg/kg. Overall N-CON group performed poorly, but the addition of probiotics in group MSP1 and MSP2 diets significantly improved performance. Feed efficiency and bird weight gain were improved (p

The study aimed to evaluate the effects of multi-strain probiotic (MSP) on broiler growth, health, and nutrient utilization under high animal protein concentrate conditions. Male Ross-308 broilers were assigned to four groups: a control (C), MSP at 50 mg/kg (MSP50), MSP at 100 mg/kg (MSP100), and Zinc bacitracin (ZB) as a positive control. MSP supplementation significantly improved feed intake, weight gain, and feed conversion efficiency, with MSP100 demonstrating the best feed conversion ratio during both starter and finisher phases. MSP also enhanced dressing percentages and positively influenced blood lipid profiles. The supplementation reduced harmful bacterial growth (E. coli, Salmonella, Clostridium perfringens) while promoting beneficial bacteria (Lactobacillus). Moreover, MSP positively impacted gut histomorphology, showing higher villus height, width, and crypt depth in the MSP100 group. Digestibility of dry matter and crude protein was enhanced in birds fed the MSP100 diet. Overall, MSP supplementation exhibited positive effects on broiler performance, health, and nutrient digestibility, indicating its potential as an antibiotic alternative for improving practices in the poultry feed industry.