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The significance of last-mile logistics in the healthcare supply chain is growing steadily, especially in pharmacies where the growing prevalence of medication delivery to patients' homes is remarkable. This paper proposes a novel mathematical model for the last-mile logistics of the pharmaceutical supply chain and optimizes a pharmacy's logistical financial outcome while considering medication synchronization, different delivery modes, and temperature requirements of medicines. We propose a mathematical formulation of the problem using Mixed Integer Linear Programming (MILP) evolved from the actual problem of an outpatient pharmacy of a Dutch hospital. We create a case study by gathering, preparing, processing, and analyzing the associated data. We find the optimal solution, using Python MIP package and the Gurobi solver, which indicates the number of order batches, the composition of these batches, and the number of staff related to the preparation of the order batches. Our results show that our optimal solution increases the pharmacy's logistical financial outcome by 34 percent. Moreover, we propose other model variations and perform extensive scenario analysis to provide managerial insights applicable to other pharmacies and distributors in the last step of cold supply chains. Based on our scenario analysis, we conclude that improving medication synchronization can significantly enhance the pharmacy's logistical financial outcome.

Agent-based simulation (ABS) models are potent tools for analyzing complex systems. However, understanding and validating ABS models can be a significant challenge. To address this challenge, cutting-edge data-driven techniques offer sophisticated capabilities for analyzing the outcomes of ABS models. One such technique is process mining, which encompasses a range of methods for discovering, monitoring, and enhancing processes by extracting knowledge from event logs. However, applying process mining to event logs derived from ABSs is not trivial, and deriving meaningful insights from the resulting process models adds an additional layer of complexity. Although process mining is invaluable in extracting insights from ABS models, there is a lack of comprehensive methodological guidance for its application in ABS evaluation in the research landscape. In this paper, we propose a methodology, based on the CRoss-Industry Standard Process for Data Mining (CRISP-DM) methodology, to assess ABS models using process mining techniques. We incorporate process mining techniques into the stages of the CRISP-DM methodology, facilitating the analysis of ABS model behaviors and their underlying processes. We demonstrate our methodology using an established agent-based model, Schelling model of segregation. Our results show that our proposed methodology can effectively assess ABS models through produced event logs, potentially paving the way for enhanced agent-based model validity and more insightful decision-making.

We consider the problem of optimizing the distribution operations at a drone hub that dispatches drones to different geographic locations generating stochastic demands for medical supplies. Drone delivery is an innovative method that introduces many benefits, such as low-contact delivery, thereby reducing the spread of pandemic and vaccine-preventable diseases. While we focus on medical supply delivery for this work, drone delivery is suitable for many other items, including food, postal parcels, and e-commerce. In this paper, our goal is to address drone delivery challenges related to the stochastic demands of different geographic locations. We consider different classes of demand related to geographic locations that require different flight ranges, which is directly related to the amount of charge held in a drone battery. We classify the stochastic demands based on their distance from the drone hub, use a Markov decision process to model the problem, and perform computational tests using realistic data representing a prominent drone delivery company. We solve the problem using a reinforcement learning method and show its high performance compared with the exact solution found using dynamic programming. Finally, we analyze the results and provide insights for managing the drone hub operations.

There is a growing interest in using electric vehicles (EVs) and drones for many applications. However, battery-oriented issues, including range anxiety and battery degradation, impede adoption. Battery swap stations are one alternative to reduce these concerns that allow the swap of depleted for full batteries in minutes. We consider the problem of deriving actions at a battery swap station when explicitly considering the uncertain arrival of swap demand, battery degradation, and replacement. We model the operations at a battery swap station using a finite horizon Markov Decision Process model for the stochastic scheduling, allocation, and inventory replenishment problem (SAIRP), which determines when and how many batteries are charged, discharged, and replaced over time. We present theoretical proofs for the monotonicity of the value function and monotone structure of an optimal policy for special SAIRP cases. Due to the curses of dimensionality, we develop a new monotone approximate dynamic programming (ADP) method, which intelligently initializes a value function approximation using regression. In computational tests, we demonstrate the superior performance of the new regression-based monotone ADP method as compared to exact methods and other monotone ADP methods. Further, with the tests, we deduce policy insights for drone swap stations.