1. Review on the recent progress in the development of fluorescent probes targeting enzymes
- Author
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Zhi-Wen Li, Shiyu Liu, Cui-Qin Xiong, Wu Ying-Zheng Guo, Yi-Xuan Fu, Guang-Fu Yang, Wen-Chao Yang, and Asanka Amith Rajapaksha
- Subjects
Arthritis ,02 engineering and technology ,Computational biology ,Disease ,010402 general chemistry ,01 natural sciences ,Human disease ,Cell Line, Tumor ,Medicine ,Animals ,Humans ,General Materials Science ,Instrumentation ,Spectroscopy ,Fluorescent Dyes ,chemistry.chemical_classification ,business.industry ,Drug administration ,021001 nanoscience & nanotechnology ,medicine.disease ,Atomic and Molecular Physics, and Optics ,0104 chemical sciences ,Highly sensitive ,Enzymes ,Enzyme ,chemistry ,Molecular Probes ,0210 nano-technology ,business ,Drug metabolism - Abstract
Enzymes are very important for biological processes in a living being, performing similar or multiple tasks in and out of cells, tissues and other organisms at a particular location. The abnormal activity of particular enzyme usually caused serious diseases such as Alzheimer’s disease, Parkinson’s disease, cancers, diabetes, cardiovascular diseases, arthritis etc. Hence, nondestructive and real-time visualization for certain enzyme is very important for understanding the biological issues, as well as the drug administration and drug metabolism. Fluorescent cellular probe-based enzyme detection in vitro and in vivo has become broad interest for human disease diagnostics and therapeutics. This review highlights the recent findings and designs of highly sensitive and selective fluorescent cellular probes targeting enzymes for quantitative analysis and bioimaging.
- Published
- 2021