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169 results on '"Asano, Krisana"'

7. The new 222‐nm far ultraviolet‐C lowers bacterial contamination to endoscopists during esophagogastroduodenoscopy

Author

Fukutoku, Yukari, primary, Kikuchi, Hidezumi, additional, Hoshi, Kentaro, additional, Narita, Kouji, additional, Asari, Taka, additional, Miyazawa, Kuniaki, additional, Sawada, Yohei, additional, Hayamizu, Shiro, additional, Tatsuta, Tetsuya, additional, Oota, Shinji, additional, Hasui, Keisuke, additional, Hiraga, Hiroto, additional, Chinda, Daisuke, additional, Mikami, Tatsuya, additional, Subsomwong, Phawinee, additional, Asano, Krisana, additional, Yamane, Kyosuke, additional, Ogawa, Yoshimasa, additional, Sasaki, Masahiro, additional, Koi, Toru, additional, Ohashi, Hiroyuki, additional, Nakane, Akio, additional, and Sakuraba, Hirotake, additional

Published
2023
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8. Vitamin A Promotes the Fusion of Autophagolysosomes and Prevents Excessive Inflammasome Activation in Dextran Sulfate Sodium-Induced Colitis

Author

Hiraga, Hiroto, primary, Chinda, Daisuke, additional, Maeda, Takato, additional, Murai, Yasuhisa, additional, Ogasawara, Kohei, additional, Muramoto, Ryutaro, additional, Ota, Shinji, additional, Hasui, Keisuke, additional, Sakuraba, Hirotake, additional, Ishiguro, Yoh, additional, Yoshida, Shukuko, additional, Asano, Krisana, additional, Nakane, Akio, additional, and Fukuda, Shinsaku, additional

Published
2023
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13. Salmon nasal cartilage proteoglycan stimulates hair growth

Author

Nakane, Akio, Hirose, Shouhei, Kawai, Noriaki, Fujimoto, Naoki, Kondo, Eriko, and Asano, Krisana

Abstract

Hair loss is a commonly encountered problem. In this study, hair growth was enhanced by daily oral ingestion of salmon nasal cartilage proteoglycan (PG) in mice. Proteoglycan stimulated vesicular endothelial growth factor production in human follicle dermal papilla cells through insulin growth factor-1 receptor signaling, suggesting the possibility of hair loss improvement by PG ingestion.

Published
2024
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14. Bacterial exposure risk to the endoscopist's face while performing endoscopy

Author

Hoshi, Kentaro, primary, Kikuchi, Hidezumi, additional, Narita, Koji, additional, Fukutoku, Yukari, additional, Asari, Taka, additional, Miyazawa, Kuniaki, additional, Murai, Yasuhisa, additional, Sawada, Yohei, additional, Tatsuta, Tetsuya, additional, Hasui, Keisuke, additional, Hiraga, Hiroto, additional, Chinda, Daisuke, additional, Mikami, Tatsuya, additional, Subsomwong, Phawinee, additional, Asano, Krisana, additional, Nakane, Akio, additional, Fukuda, Shinsaku, additional, and Sakuraba, Hirotake, additional

Published
2023
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23. Effects of salmon cartilage proteoglycan on obesity in mice fed with a high‐fat diet.

Author

Hirose, Shouhei, Asano, Krisana, Harada, Seiyu, Takahashi, Tatsuji, Kondou, Eriko, Ito, Kenichi, Iddamalgoda, Arunasiri, and Nakane, Akio

Subjects
*HIGH-fat diet, *LEPTIN, *CARTILAGE, *BLOOD lipids, *MICE, *SALMON
Abstract

This study investigated the effects of salmon nasal cartilage proteoglycan (PG), which shows anti‐inflammatory properties, on obesity induced by high‐fat diet (HFD) in a mouse model. Mice were fed either a HFD or normal diet (ND), with or without PG, for 8–12 weeks. After 12 weeks, the body weight of mice fed with PG‐free HFD was 54.08 ± 4.67 g, whereas that of mice fed with HFD containing PG was 41.83 ± 4.97 g. The results suggest that the increase in body weight was attenuated in mice fed with HFD containing PG. This effect was not observed in mice fed with ND. The PG administration suppressed the elevation of serum lipids (the level of serum lipids ranged between 54% and 69% compared to 100% in mice fed with PG‐free HFD) and the upregulated mRNA expression of sterol regulatory element‐binding protein‐1c (SREBP‐1c), which is a transcription factor that acts as a master regulator of lipogenic gene expression in the liver (the expression level was 77.5% compared to 100% in mice fed with PG‐free HFD). High leptin levels in mice fed with PG‐free HFD were observed during fasting (average at 14,376 ng/ml), and they did not increase after refeeding (average of 14,263 ng/ml), whereas serum leptin levels in mice fed with HFD containing PG were low during fasting (average of 6481 ng/ml) and increased after refeeding (average 13,382 ng/ml). These results suggest that PG feeding has an anti‐obesity effect and that the regulation of SREBP‐1c and leptin secretion play a role in this effect. [ABSTRACT FROM AUTHOR]

Published
2022
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30. Interplay Between Autophagy and Pathogenic Bacteria : Toxins Secreted by Staphylococcus Aureus and Their Impact

Author

Asano, Krisana and Nakane, Akio

Subjects
Staphylococcus aureus, autophagy, intracellular pathogens, toxic shock syndrome toxin-1, alpha-hemolysin, 医学
Abstract

Autophagy, a cellular homeostatic pathway, is emerged as an innate immune response against intracellular pathogens. It can directly eliminate invading bacteria by mediating their delivery to lysosomes. However, successful intracellular pathogens have developed mechanism（s） to escape or subvert autophagy for their intracellular niches. Studies on interplay between autophagy and intracellular pathogens are very important for understanding how infections occur. Particularly, Staphylococcus aureus is an important opportunistic pathogen that causes a wide range of infections. Classically, S. aureus is considered as an extracellular pathogen, but cumulative evidence indicates that this bacterium invades epithelial cells and replicates intracellularly which is relevant to intracellular persistence and chronic infections. A serious therapeutic problem of staphylococcal infections is caused by antibiotic resistant strains which have emerged increasingly in recent years. Thus, new insights in the strategy of S. aureus to interplay with autophagy is urgently required. This review highlights an impact of S. aureus toxins on autophagy. Alpha-hemolysin activates autophagy and prevents lysosome-autophagosome fusion, whereas toxic shock syndrome toxin-1 suppresses autophagosome formation. This opposite function indicates a complicated relationship between autophagy and intracellular adaptation of S. aureus. The possible effects of these toxins on S. aureus infections are also addressed in this review., 弘前医学. 67, 2017, p.115-128

Published
2017

35. 222-nm UVC inactivates a wide spectrum of microbial pathogens.

Author

Narita, K., Asano, K., Naito, K., Ohashi, H., Sasaki, M., Morimoto, Y., Igarashi, T., Nakane, A., Narita, Kouji, Asano, Krisana, Naito, Keisuke, Ohashi, Hiroyuki, Sasaki, Masahiro, Morimoto, Yukihiro, Igarashi, Tatsushi, and Nakane, Akio

Abstract

Background: UVC has been used to inactivate several pathogens. Unlike the conventional 254-nm UVC, 222-nm UVC is harmless to mammalian cells.Aim: To investigate the disinfection efficacy of 222-nm UVC against human pathogens which are commonly found in the environment and healthcare facilities.Methodology: Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Salmonella enterica subsp. serovar Typhimurium, Campylobacter jejuni, Bacillus cereus (vegetative cells and endospores), Clostridium sporogenes (vegetative cells and endospores), Clostoridioides difficile (endospores), Candida albicans (yeast), Aspergillus niger (hyphae and spores), Trichophyton rubrum (hyphae and spores), feline calicivirus and influenza A virus were irradiated with 222-nm UVC at various doses. The remaining live bacterial and fungal cells, and the viral infectivity were evaluated. The efficiency of 222-nm UVC germicidal effect was compared to that of the conventional 254-nm UVC.Results: The 222-nm UVC showed potent germicidal effect to vegetative bacterial cells, yeast and viruses as efficient as the 245-nm UVC. The 222-nm UVC exhibited more potent germicidal effect to bacterial endospores, compared with the 254-nm UVC. The fungicidal effect of 222-nm UVC against the fungal spores and hyphae was weaker than that of 254-nm UVC.Conclusions: The 222-nm UVC is able to inactivate a wide spectrum of microbial pathogens. In comparison with the conventional 254-nm UVC, the germicidal effect of 222-nm UVC to the fungal hyphae and spores is low, but the 222-nm UVC exhibits strong germicidal effect to the bacterial endospores. [ABSTRACT FROM AUTHOR]

Published
2020
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39. イデンシ クミカエ ドクソセイ ショック ショウコウグン ドクソ-1 ニヨル ジョウヒ サイボウ ノ キガ ユウドウ オートファジー ノ ヨクセイ

Author

Asano, Krisana

Subjects
body regions, 491.6, endocrine system, bacteria, 基礎医学, bacterial infections and mycoses
Abstract

Toxic shock syndrome toxin-1 (TSST-1), a superantigen produced from Staphylococcus aureus, has been reported to bind directly to unknown receptor(s) and penetrate into non-immune cells but its function is unclear. In this study, we demonstrated that recombinant TSST-1 suppresses autophagosomal accumulation in the autophagic-induced HeLa 229 cells. This suppression is shared by a superantigenic-deficient mutant of TSST-1 but not by staphylococcal enterotoxins, suggesting that autophagic suppression of TSST-1 is superantigenic-independent. Furthermore, we showed that TSST-1-producing S. aureus suppresses autophagy in the response of infected cells. Our data provides a novel function of TSST-1 in autophagic suppression which may contribute in staphylococcal persistence in host cells., 掲載誌 PLoS ONE, November 17, 2014 http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0113018, 掲載誌 PLOS One, 2014 http://dx.doi.org/10.1371/journal.pone.0113018

Published
2015

44. Oral administration of salmon cartilage proteoglycan extends the survival of allografts in mice.

Author

Asano, Krisana, Takahashi, Emiko, Yoshimura, Sayuri, and Nakane, Akio

Subjects
*PROTEOGLYCANS, *GRAFT rejection prevention, *HOMOGRAFTS, *SKIN grafting, *LABORATORY mice
Abstract

Proteoglycan (PG) is a complex glycohydrate that is widely distributed in the extracellular matrix. Oral administration of PG extracted from salmon nasal cartilage has been reported to attenuate the severity and proinflammatory cytokine responses in mouse experimental colitis, autoimmune encephalomyelitis, collagen-induced arthritis and obesity-induced inflammation. In the present study, the effects of salmon nasal cartilage PG on skin allografts were investigated in a mouse model. Oral administration of PG prolonged the survival of skin grafts within 10 days of transplantation. Although PG failed to inhibit allograft rejection at the final stage of transplantation, PG attenuated the cell infiltration in the skin under the transplanted site. [ABSTRACT FROM AUTHOR]

Published
2018
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46. Endo-1,4-beta-xylanase B from Aspergillus cf. niger BCC14405 isolated in Thailand: purification, characterization and gene isolation

Author

Gobsuk Jarupan, Sriprang Rutchadaporn, Asano Krisana, Tanapongpipat Sutipa, Kirtikara Kanyawim, and Eurwilaichitr Lily

Subjects
Copper Sulfate, DNA, Complementary, Molecular Sequence Data, Biology, Biochemistry, Polymerase Chain Reaction, Homology (biology), Substrate Specificity, Open Reading Frames, Complementary DNA, Amino Acid Sequence, Cloning, Molecular, Molecular Biology, Betula, Edetic Acid, Thermostability, chemistry.chemical_classification, Endo-1,4-beta Xylanases, Molecular mass, Base Sequence, General Medicine, Thailand, Enzyme assay, Open reading frame, Enzyme, chemistry, Xylanase, biology.protein, Xylans, Aspergillus niger, Sequence Alignment
Abstract

During the screening of xylanolytic enzymes from locally isolated fungi, one strain BCC14405, exhibited high enzyme activity with thermostability. This fugal strain was identified as Aspergillus cf. niger based on its morphological characteristics and internal transcribed spacer (ITS) sequences. An enzyme with xylanolytic activity from BCC14405 was later purified and characterized. It was found to have a molecular mass of ca. 21 kDa, an optimal pH of 5.0, and an optimal temperature of 55 degrees C. When tested using xylan from birchwood, it showed K(m) and V(max) values of 8.9 mg/ml and 11,100 U/mg, respectively. The enzyme was inhibited by CuSO(4) EDTA, and by FeSO(4) The homology of the 20-residue N-terminal protein sequence showed that the enzyme was an endo-1,4-beta-xylanase. The full-length gene encoding endo-1,4-beta-xylanase from BCC14405 was obtained by PCR amplification of its cDNA. The gene contained an open reading frame of 678 bp, encoding a 225 amino acid protein, which was identical to the endo-1,4-a-xylanase B previously identified in A. niger.

Published
2005

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