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16 results on '"Asemi-Rad, Azam"'

7. Association between the organic cation transporter 3 methylation and hepatocellular carcinoma.

Author

Heidari, Zahra, Asemi-Rad, Azam, Moudi, Bita, and Mahmoudzadeh-Sagheb, Hamidreza

Subjects
*ORGANIC cation transporters, *HEPATOCELLULAR carcinoma, *CANCER genetics, *POLYMERASE chain reaction, *MESSENGER RNA
Abstract

Hepatocellular carcinoma (HCC) is one of the deadliest cancers in the world and has a high death rate in the world. This research while examining the expression of OCT3 at the mRNA level has also studied gene methylation profile in patients with HCC in comparison with people without HCC. The volunteers were: patients with HCC (n=81) and a healthy control group (n=90). The expression of OCT3was studied using the qRT-PCR method. The methylation profile was evaluated by genomic DNA using methylation specific PCR (MSP) method. The expression level of OCT3 marker mRNA in patients has decreased significantly compared to healthy individuals (0.58 ± 0.311 vs 1.20 ± 0.355, P <0.001). No significant statistical relationship was found between demographic data and OCT3 expression in participants (P >0.05). The amount of methylation (UM + MM) in cancer patients has raised vs controls (P <0.001) and has increased the risk of cancer (OR=0.379, 95% CI=1.171-2.839, P <0.001, and OR=2.727, 95% CI=1.251-5.945, P <0.001, respectively). Changes in OCT3 levels appear to be associated with HCC. Also, changing the methylation pattern of this gene can reveal HCC pathology. [ABSTRACT FROM AUTHOR]

Published
2023
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9. Dopaminergic neuron transplantation and melatonin co-administration protects neurodegeneration and reverse oxidative stress-induced cell death in rat model of Parkinson’s disease

Author

Asemi-Rad, Azam, primary, moafy, maral, additional, aliaghaei, abbas, additional, Abbaszadeh, Hojjat-Allah, additional, abdollahifar, mohammad-amin, additional, ebrahimi, mohammad-javad, additional, heidari, mohammad-hassan, additional, and sadeghi, yousef, additional

Published
2021
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