9 results on '"Ashraf Ederies"'
Search Results
2. Neuroimaging of Fetal Infection
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C Marchal, D D McIntire, M Massoud, F Lazzini, N Linder, D Levine, C Gutiérrez-Márquez, L A Bailão, G L Hedlund, G C Meyberg-Solomayer, G G Colleoni, A Benachi, T R de Haan, L Quartulli, P M Jayaram, G F Eich, L W Averill, A Vorsselmans, F Bonilla-Musoles, A Vossough, M S van der Knaap, L Geerts, F Dhombres, D Kidron, M L Watt-Morse, F Peyron, J Pardo, J Nijman, J Amir, J E Sanín-Blair, N P Deasy, H Werner, J Atias, M de Santis, M T Whitehead, P T Levy, P Tomà, M Vouga, S Friszer, A Buenerd, B Tatli, G Malm, G Duarte, B Weisz, H Buxmann, G Hartnoll, A Perolo, P Bonasoni, S Stagno, B Tseng, Y J Crow, R Biancheri, T Lerman-Sagie, K Dewar, M A Verboon-Maciolek, D O'Rourke, O Picone, M A al Thagafi, J T Parer, M L Rossi, S Lipitz, M Mohlo, F Brunelle, L Schuler-Faccini, J L Anderson, O A Glenn, R Wright, D Lev, M Uriel, D M Twickler, L R Pistorius, M Wien, L M Hill, F Piersigilli, B Maugey-Laulom, R F Pass, C E Lindan, A Beke, Y Murakami, H Gunardi, B Guerra, R Salmaso, E Martin, V Wiwanitkit, G Sournies, D Warren, A Yuksel, M L Kulkarni, G R Nagy, Y Mogami, K Latkóczy, A Carletti, J C Rodriguez Leonel, Y Suzuki, A Zerem, N Teissier, Y Yinon, G Cloud, L S de Vries, C A Alford, I Simon, B Suarez, P Mezzano, P Pinaud, C Soussotte, A A Karparov, M C Maberry, P Soares de Oliveira-Szejnfeld, G M Magnano, A L White, T Drier de Laforte, A G Cordier, M Besnard, S al Shahwan, P W Callen, M D King, F H Carvalho, L J Salomon, Y Akyol, A S Melo, D Nadal, M I Steinlin, E Araujo Júnior, M L Daniel, C Cluver, C R Wake, K Yanagihara, M Nishioka, I H Kalelioglu, Ashley J. Robinson, A Rossi, E Done, C Auriti, D Pugash, Y Toribe, J Gunkel, A C Regenstein, W K Oliveira, P Maurice, J F Bale, F Gay-Andrieu, N M Mehta, K B Fowler, G M Schauer, L A Ramenghi, L A Bok, M M Cannie, C Parazzini, R Has, S A Laifer, A Righini, A J Barkovich, P Sonigo, M Epelman, M Feldmann, M Tamarkin, A M Kulkarni, Y Ville, E J Boltshauser, S Domizio, A Yildirim, B Feldman, W Bonacci, S Sigaudy, S Ryan, N Farkas, G A Vorona, J Garcia-Flores, E Schiff, E Cristina, C Y Ho, A U Stücker, S N Bryant, S Parisot, V V Kandula, J M Jarosz, B J Freij, C Gire, J M Jouannic, K B Leonard, P S Dimova, G J Demmler, N G Osborne, L Sanapo, L Guibaud, M R De Gasperis, P Guillemette-Artur, L Ben-Sira, S Baskar, T C Cox, C P Dunham, T Matsuishi, M Recio, S M Lanni, E M Korhonen, B Joob, M M Amorim, Y Dogan, G V França, M Motobayashi, L Tychsen, P G Barth, D Baud, C L Ong, P Marty, T C Bailão, M Nishikawa, D Carles, L Bradley, P Droulle, N Girard, D M Money, S Stivaros, M W Rac, D A Herrera, W J Britt, M Severino, J H Livingston, I Muller-Hansen, N Zahalka, M C Rizzi, M. Ashraf Ederies, E H Gröndahl, M Cagneaux, T J Boll, J Pialat, J R Marquis, C Garel, F S Cole, R Franco, J Perlman, J Attia-Sobol, N Oosterom, M Leyder, J L Sever, D Prayer, T Fehm, D Eyrolle-Guignot, R S Aguiar, D J Bonthius, G Malinger, M Tepperberg-Dikawa, F Groenendaal, G Serra, H Odendaal, A Reitter, G Seganti, G Tonni, C Doneda, C Hoffmann, L Ben Sira, C D Smyser, F Jacquemard, Y Yamashita, G Sabatino, G Simonazzi, A D Bardeguez, R Meyer, J P Crino, E Hughes, J Courtier, R W Driggers, Y Inaba, F Diard, R Devlieger, I Lewensohn-Fuchs, G Hendson, M L Engman, J Smal, and G Benoist
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Pregnancy ,030219 obstetrics & reproductive medicine ,medicine.diagnostic_test ,business.industry ,Transmission (medicine) ,Neurotropism ,Congenital cytomegalovirus infection ,Magnetic resonance imaging ,medicine.disease ,Review article ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,Neuroimaging ,Pediatrics, Perinatology and Child Health ,Immunology ,medicine ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Infection during pregnancy is common and the developing fetal brain is vulnerable to vertical transmission due to immaturity of the fetal immune system. Infection is a major cause of multiple organ abnormalities, including the neuraxis, due to the neurotropism of the infectious agents. This review sets out to give an overview of fetal infection, review the general principles of the nature and timing of the infectious insult with respect to outcomes, review the neuroimaging of infection by ultrasound and magnetic resonance imaging (MRI), and review the various pathogens involved, including the two most common, cytomegalovirus (CMV) and Toxoplasma, and also other common viral and nonviral infections.
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- 2017
3. Diagnostic imaging of posterior fossa anomalies in the fetus
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M. Ashraf Ederies and Ashley James Robinson
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medicine.medical_specialty ,Developmental Disabilities ,Posterior fossa ,Prenatal diagnosis ,Nervous System Malformations ,03 medical and health sciences ,0302 clinical medicine ,Dandy–Walker syndrome ,Cerebellum ,Prenatal Diagnosis ,Medical imaging ,medicine ,Humans ,030219 obstetrics & reproductive medicine ,Modality (human–computer interaction) ,medicine.diagnostic_test ,business.industry ,Ultrasound ,Magnetic resonance imaging ,Anatomy ,medicine.disease ,Echoencephalography ,Magnetic Resonance Imaging ,Cranial Fossa, Posterior ,Pediatrics, Perinatology and Child Health ,Radiology ,Dandy-Walker Syndrome ,business ,030217 neurology & neurosurgery - Abstract
Ultrasound and magnetic resonance imaging are the two imaging modalities used in the assessment of the fetus. Ultrasound is the primary imaging modality, whereas magnetic resonance is used in cases of diagnostic uncertainty. Both techniques have advantages and disadvantages and therefore they are complementary. Standard axial ultrasound views of the posterior fossa are used for routine scanning for fetal anomalies, with additional orthogonal views directly and indirectly obtainable using three-dimensional ultrasound techniques. Magnetic resonance imaging allows not only direct orthogonal imaging planes, but also tissue characterization, for example to search for blood breakdown products. We review the nomenclature of several posterior fossa anomalies using standardized criteria, and we review cerebellar abnormalities based on an etiologic classification.
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- 2016
4. G356 Decision making management guideline for patients (<19 y) with idiopathic thickened pituitary stalk and/or idiopathic central diabetes insipidus
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Johannes Visser, I Kamali, C Bulwer, Ashraf Ederies, Ashley B. Grossman, Manuela Cerbone, Helen Spoudeas, and Márta Korbonits
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0301 basic medicine ,Pituitary stalk ,Pediatrics ,medicine.medical_specialty ,business.industry ,Nice ,Neurosarcoidosis ,Audit ,Guideline ,030105 genetics & heredity ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Diabetes insipidus ,medicine ,Etiology ,Differential diagnosis ,business ,computer ,030217 neurology & neurosurgery ,computer.programming_language - Abstract
Aim To develop a guideline for the investigation and management of children and young people up to the age of 19 years with idiopathic thickened pituitary stalk (iTPS) and/or central diabetes insipidus (iCDI) where the aetiology is not apparent at presentation. Methods The guideline development group (GDG) identified the objectives and the clinical questions which needed to be addressed. These were reviewed by guideline stakeholders and used to direct a systematic literature search. Published evidence was appraised using the GRADE system. Where the literature search identified sufficient evidence, the GDG made a guideline recommendation. Where there was insufficient evidence, the GDG drafted recommendations based on their expert opinion and reviewed these using a formal Delphi consensus process. This was a joint society (BSPED/CCLG) multidisciplinary national endeavour done to NICE methodology and overseen by RCPCH. Results The literature search identified 568 articles covering the period Jan 1990 –March 2017. The most commonly reported causes of iTPS and iCDI in children are Langerhans Cell Hystiocytosis (LCH), Germ Cell Tumours (GCT) and craniopharingioma (CP). The average prevalence of LCH, GCT and CP in 11 case series (including 741 patients) is 16%, 13% and 12%, respectively. Overall, congenital defects are responsible for 19% of the iTPS/iCDI cases, whilst infectious diseases (2%), trauma (1%) and inflammatory/autoimmune conditions (1%) rarely occur in children. In 29% of the cases no aetiology is identified. Causes of pituitary stalk lesions in adults, metastatic tumours and neurosarcoidosis, do not form part of the differential diagnosis in children. What constitutes a TPS is not consistently defined across studies. High quality evidence was lacking for the majority of the clinical questions and two rounds of Delphi consensus were undertaken. A decision-making flowchart has been developed and will accompany the guideline. Conclusion The likely aetiology of iTPS and iCDI in children differs from that in adults and justifies the development of age appropriate decision making management guidelines to inform best practice nationally. This will form the basis for future audits of practice and outcomes and is intended to improve the quality of care of children and young people with iTPS and iCDI.
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- 2018
5. Fetal neuroimaging: an update on technical advances and clinical findings
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M. Ashraf Ederies and Ashley J. Robinson
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medicine.medical_specialty ,Computed tomography ,Neuroimaging ,Nervous System Malformations ,03 medical and health sciences ,0302 clinical medicine ,Fetus ,Central Nervous System Diseases ,Pregnancy ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Neuroradiology ,030219 obstetrics & reproductive medicine ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,Fetal Diseases ,Morphometric analysis ,Fetal imaging ,Pediatrics, Perinatology and Child Health ,Female ,Radiology ,business ,030217 neurology & neurosurgery ,Diffusion MRI - Abstract
This paper is based on a literature review from 2011 to 2016. The paper is divided into two main sections. The first section relates to technical advances in fetal imaging techniques, including fetal motion compensation, imaging at 3.0 T, 3-D T2-weighted MRI, susceptibility-weighted imaging, computed tomography, morphometric analysis, diffusion tensor imaging, spectroscopy and fetal behavioral assessment. The second section relates to clinical updates, including cerebral lamination, migrational anomalies, midline anomalies, neural tube defects, posterior fossa anomalies, sulcation/gyration and hypoxic–ischemic insults.
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- 2017
6. GERM-22. DECISION-MAKING MANAGEMENT GUIDELINE FOR CHILDREN AND YOUNG PEOPLE UP TO 19 YEARS (CYP) PRESENTING WITH IDIOPATHIC PITUITARY STALK THICKENING (iTPS) AND/OR IDIOPATHIC CENTRAL DIABETES INSIPIDUS (iCDI)
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Kirtana Vallabhaneni, Manuela Cerbone, Chloe Bulwer, Helena Gleeson, Johannes Visser, Ian Kamaly, Ashraf Ederies, Thomas S. Jacques, Márta Korbonits, Stephen Ball, Ashley B. Grossman, Vasanta Nanduri, Vaya Tziaferi, and Helen Spoudeas
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Pituitary stalk ,Cancer Research ,Pituitary gland ,Pediatrics ,medicine.medical_specialty ,business.industry ,Management guideline ,medicine.disease ,Abstracts ,medicine.anatomical_structure ,Oncology ,Infundibular Stem ,Expert opinion ,Diabetes insipidus ,Medicine ,Neurology (clinical) ,Thickening ,business - Abstract
AIM: To develop a high-quality national guideline for the assessment and management of CYP presenting with iTPS and/or iCDI before their 19th birthday, as a joint endeavour by the Britsh paediatric endocrine and oncology societies (BSPED/CCLG) and meeting approved commissioning standards (RCPCH/NIHCE). METHODS: The interdisciplinary guideline development group (GDG) identified 64 clinical questions. These were reviewed by stakeholders and used to direct a systematic literature search (January 1990 - March 2017). 568 articles were appraised using the GRADE system. Where there was sufficient evidence, the GDG made a guideline recommendation. Where high quality evidence was lacking, the GDG drafted recommendations based on their expert opinion and reviewed these using two rounds of Delphi consensus with international experts. RESULTS: In 11 case series (741 paediatric patients) the commonest individual causes of TPS/CDI were Langerhans cell hystiocytosis (16%), germ cell tumours (13%) and craniopharingiomas (12%). A range of congenital defects accounted for 19% of cases. Infectious diseases (2%), trauma (1%) and inflammatory/autoimmune conditions (1%) were rare. Twenty-nine percent remained idiopathic and some causes of TPS in adults (metastatic tumours and neurosarcoidosis) were not reported in children. The definition of TPS was not consistent across studies. A guideline and decision-making flowchart were developed. CONCLUSION: The likely aetiology of TPS/CDI in children differs from that in adults and justifies the development of age-appropriate management guidelines. This will form the basis of future audits of practice and outcomes and is intended to improve the care and service provision to CYP with apparent idiopathic TPS/CDI.
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- 2018
7. Postcontrast CT Extravasation Is Associated With Hematoma Expansion in CTA Spot Negative Patients
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David J. Gladstone, Andrew M. Demchuk, Gabriel BenDavit, Tze Chia, Kelly Wong, Ashraf Ederies, Dar Dowlatshahi, Sean P. Symons, and Richard I. Aviv
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Adult ,Male ,medicine.medical_specialty ,Blood Pressure ,Central nervous system disease ,Hematoma ,Image Processing, Computer-Assisted ,medicine ,Humans ,Stroke ,Aged ,Cerebral Hemorrhage ,Retrospective Studies ,Computed tomography angiography ,Advanced and Specialized Nursing ,medicine.diagnostic_test ,business.industry ,Vascular disease ,Middle Aged ,medicine.disease ,Extravasation ,Cerebral Angiography ,Angiography ,Female ,Partial Thromboplastin Time ,Neurology (clinical) ,Radiology ,Tomography, X-Ray Computed ,Cardiology and Cardiovascular Medicine ,business ,Extravasation of Diagnostic and Therapeutic Materials ,Cerebral angiography - Abstract
Background and Purpose— The purpose of this study was to assess the effect of postcontrast CT (PCCT) leakage (PCL) on hematoma growth in CTA spot negative patients. Methods— A retrospective study of 61 patients presenting within 6 hours of primary ICH onset imaged with CT angiography (CTA) and PCCT. Presence of CTA spot sign and PCL were documented. PCL was defined as the presence of contrast extravasation on the PCCT study at a location remote from the CTA spot sign if present. Hematoma expansion was defined as >6 mL or 30% hematoma enlargement. Patients were dichotomized by CTA spot sign presence and PCL and compared for baseline demographic data, hematoma size, and growth using the unpaired t test and Mann-Whitney test for continuous and categorical data, respectively. A probability value Results— PCL was present in 11/61 patients (18%), occurring in 5 without a spot sign (45%). Spot negative PCL patients demonstrated larger absolute ( P =0.02) and percentage hematoma growth ( P =0.02) compared to those without PCL. The mean volume and percent increase was 6.7 mL and 26%, respectively. Inclusion of PCL together with CTA spot sign as risk factor for hematoma expansion increased sensitivity from 0.78 (95% CI; 0.52 to 0.94) to 0.94 (95% CI; 0.72 to 1.00) and NPV from 0.90 (95% CI; 0.76 to 0.97) to 0.97 (95% CI; 0.85 to 1.00). Conclusion— Inclusion of PCCT in the investigation of ICH patients allows detection of PCL which, together with the CTA spot sign, increases sensitivity and negative predictive value for predicting hematoma expansion. This finding should be validated in larger studies.
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- 2009
8. Specialization and integration of functional thalamocortical connectivity in the human infant
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Hilary, Toulmin, Christian F, Beckmann, Jonathan, O'Muircheartaigh, Gareth, Ball, Pumza, Nongena, Antonios, Makropoulos, Ashraf, Ederies, Serena J, Counsell, Nigel, Kennea, Tomoki, Arichi, Nora, Tusor, Mary A, Rutherford, Denis, Azzopardi, Nuria, Gonzalez-Cinca, Joseph V, Hajnal, and A David, Edwards
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Cerebral Cortex ,Oxygen ,Child Development ,Thalamus ,Neural Pathways ,Age Factors ,Infant, Newborn ,Humans ,Biological Sciences ,Magnetic Resonance Imaging ,Infant, Premature - Abstract
Connections between the thalamus and cortex develop rapidly before birth, and aberrant cerebral maturation during this period may underlie a number of neurodevelopmental disorders. To define functional thalamocortical connectivity at the normal time of birth, we used functional MRI (fMRI) to measure blood oxygen level-dependent (BOLD) signals in 66 infants, 47 of whom were at high risk of neurocognitive impairment because of birth before 33 wk of gestation and 19 of whom were term infants. We segmented the thalamus based on correlation with functionally defined cortical components using independent component analysis (ICA) and seed-based correlations. After parcellating the cortex using ICA and segmenting the thalamus based on dominant connections with cortical parcellations, we observed a near-facsimile of the adult functional parcellation. Additional analysis revealed that BOLD signal in heteromodal association cortex typically had more widespread and overlapping thalamic representations than primary sensory cortex. Notably, more extreme prematurity was associated with increased functional connectivity between thalamus and lateral primary sensory cortex but reduced connectivity between thalamus and cortex in the prefrontal, insular and anterior cingulate regions. This work suggests that, in early infancy, functional integration through thalamocortical connections depends on significant functional overlap in the topographic organization of the thalamus and that the experience of premature extrauterine life modulates network development, altering the maturation of networks thought to support salience, executive, integrative, and cognitive functions.
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- 2015
9. Magnetic resonance imaging of white matter diseases of prematurity
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Luca A. Ramenghi, Mustafa Anjari, Andrew Chew, Laura Bassi, Serena J. Counsell, Mary A. Rutherford, Michela Groppo, Veena Supramaniam, and Ashraf Ederies
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Male ,medicine.medical_specialty ,Pathology ,Pediatrics ,Neurology ,Germinal matrix ,Nerve Fibers, Myelinated ,Cerebral palsy ,White matter ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Neuroradiology ,medicine.diagnostic_test ,business.industry ,Infant, Newborn ,Brain ,Magnetic resonance imaging ,medicine.disease ,Hyperintensity ,medicine.anatomical_structure ,Female ,Neurology (clinical) ,Neurosurgery ,Cardiology and Cardiovascular Medicine ,business ,Infant, Premature ,Demyelinating Diseases - Abstract
Periventricular leucomalacia (PVL) and parenchymal venous infarction complicating germinal matrix/intraventricular haemorrhage have long been recognised as the two significant white matter diseases responsible for the majority of cases of cerebral palsy in survivors of preterm birth. However, more recent studies using magnetic resonance imaging to assess the preterm brain have documented two new appearances, adding to the spectrum of white matter disease of prematurity: punctate white matter lesions, and diffuse excessive high signal intensity (DEHSI). These appear to be more common than PVL but less significant in terms of their impact on individual neurodevelopment. They may, however, be associated with later cognitive and behavioural disorders known to be common following preterm birth. It remains unclear whether PVL, punctate lesions, and DEHSI represent a continuum of disorders occurring as a result of a similar injurious process to the developing white matter. This review discusses the role of MR imaging in investigating these three disorders in terms of aetiology, pathology, and outcome.
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- 2010
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