41 results on '"Ashworth, Ian W."'
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2. N-Nitrosamine Formation in Pharmaceutical Solid Drug Products: Experimental Observations
3. The Landscape of Potential Small and Drug Substance Related Nitrosamines in Pharmaceuticals
4. Activation of Fluoride Anion as Nucleophile in Water with Data-Guided Surfactant Selection
5. Revisiting the Landscape of Potential Small and Drug Substance Related Nitrosamines in Pharmaceuticals
6. A Consideration of the Extent That Tertiary Amines Can Form N-Nitroso Dialkylamines in Pharmaceutical Products
7. Formation of Dialkyl-N-nitrosamines in Aqueous Solution: An Experimental Validation of a Conservative Predictive Model and a Comparison of the Rates of Dialkyl and Trialkylamine Nitrosation
8. Approaches and Considerations for the Investigation and Synthesis of N‑Nitrosamine Drug Substance-Related Impurities (NDSRIs).
9. Development and Manufacture of a Curtius Rearrangement Using Continuous Flow towards the Large-Scale Manufacture of AZD7648
10. Process Development, Manufacture, and Understanding of the Atropisomerism and Polymorphism of Verinurad
11. Evidence of Rate Limiting Proton Transfer in an SNAr Aminolysis in Acetonitrile under Synthetically Relevant Conditions
12. Prediction of ring formation efficiency via diene ring closing metathesis (RCM) reactions using the M06 density functional
13. Prediction of N-Nitrosamine Partition Coefficients for Derisking Drug Substance Manufacturing Processes
14. Process Development, Manufacture, and Understanding of the Atropisomerism and Polymorphism of Verinurad.
15. Evidence of Rate Limiting Proton Transfer in an SNAr Aminolysis in Acetonitrile under Synthetically Relevant Conditions.
16. Potential for the Formation of N-Nitrosamines during the Manufacture of Active Pharmaceutical Ingredients: An Assessment of the Risk Posed by Trace Nitrite in Water
17. Evidence of Rate Limiting Proton Transfer in an SNAr Aminolysis in Acetonitrile under Synthetically Relevant Conditions
18. Enolization rates control mono- versus di-fluorination of 1,3-dicarbonyl derivatives
19. Process Development of a Suzuki Reaction Used in the Manufacture of Lanabecestat
20. Understanding the Alkylation of a Phenol by 1-(3-Chloropropyl)pyrrolidine: Evidence for the Intermediacy of an Azetidinium Ion
21. Stereoretentive Etherification of an α-Aryl-β-amino Alcohol Using a Selective Aziridinium Ring Opening for the Synthesis of AZD7594
22. A General Liquid–Liquid Partitioning Equation and Its Consequences: Learning from the pH Dependent Extraction of a Pharmaceutical Intermediate
23. A quantitative reactivity scale for electrophilic fluorinating reagents
24. Kinetics and mechanism of N-Boc cleavage: evidence of a second-order dependence upon acid concentration
25. Understanding the Alkylation of a Phenol by 1‑(3-Chloro-propyl)-pyrrolidine: Evidence for the Intermediacy of an Azetidinium Ion.
26. Stereoretentive Etherification of an α‑Aryl-β-amino Alcohol Using a Selective Aziridinium Ring Opening for the Synthesis of AZD7594.
27. Understanding the Alkylation of a Phenol by 1-(3-Chloropropyl)pyrrolidine: Evidence for the Intermediacy of an Azetidinium Ion
28. Olefin Metathesis by Grubbs–Hoveyda Complexes: Computational and Experimental Studies of the Mechanism and Substrate-Dependent Kinetics
29. Where Has My Acid Gone? Understanding the Self-Catalyzed Esterification of Maleic Acid in Methanol During Salt Formation
30. Searching for the Hidden Hydrides: The Competition between Alkene Isomerization and Metathesis with Grubbs Catalysts
31. Why is RCM Favoured Over Dimerisation? Predicting and Estimating Thermodynamic Effective Molarities by Solution Experiments and Electronic Structure Calculations
32. Toward a Simulation Approach for Alkene Ring-closing Metathesis: Scope and Limitations of a Model for RCM
33. What is the initiation step of the Grubbs-Hoveyda olefinmetathesiscatalyst?
34. ChemInform Abstract: Chapter 9: Reaction Mechanisms. Part 1. Polar Reactions
35. On the relationship between structure and reaction rate in olefin ring-closing metathesis
36. Trisubstituted cyclooctene synthesis at the limits of relay ring-closing metathesis: a racemic difluorinated analogue of fucose
37. Chapter 3. Reaction mechanisms. Part (ii) Polar reactions
38. ChemInform Abstract: Chapter 9: Reaction Mechanisms. Part 1. Polar Reactions.
39. Evidence of Rate Limiting Proton Transfer in an S N Ar Aminolysis in Acetonitrile under Synthetically Relevant Conditions.
40. Solvent effects on Grubbs' pre-catalyst initiation rates.
41. Why is RCM favoured over dimerisation? Predicting and estimating thermodynamic effective molarities by solution experiments and electronic structure calculations.
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