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5. Safety assessment of genetically modified rice expressing Cry1Ab protein in Sprague–Dawley rats

Author

Hajimohammadi, Bahador, Eslami, Gilda, Zandi, Hengameh, Ehrampoush, Mohammad Hassan, Naimi, Azar, Derakhshan, Maryam, Hedayat, Pegah, Fallahi, Roozbeh, Fallahzadeh, Hossein, Rezvani, Mohammad Ebrahim, Vakili, Mahmoud, Moshtaghioun, Seyed Mohammad, Athari, Seyyed Shamsadin, Asadi-Yousefabad, Seyedeh Leili, Hosseini, Saeedeh Sadat, Shirdeli, Mehrnoush, Ahmadian, Salman, Mortazavi, Shirin, Loni, Elahe, Ajamein, Vahid, Ahmadi, Amin, and Askari, Vahideh

Published
2021
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7. Cystic Echinococcosis in Central Iran: G1 and G6 Genotypes in Patients

Author

Kargar, Saeed, primary, Dalimi, Abdolhossein, additional, Eslami, Gilda, additional, Hajimohammadi, Bahador, additional, Shirinzadeh, Ahmad, additional, Amouei, Abdolhamid, additional, Zare, Mohammad, additional, Jafari-Nedooshan, Jamal, additional, Heiranizadeh, Naeimeh, additional, Akhavan Tafti, Mahmood, additional, Ahmadian, Salman, additional, Hosseini, Saeedeh Sadat, additional, Askari, Vahideh, additional, Sheykhzadegan, Maryam, additional, Ghoshouni, Hamed, additional, Ranjbar, Mohammad Javad, additional, Boozhmehrani, Mohammad Javad, additional, and Vakili, Mahmood, additional

Published
2022
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10. Relationship between Serum Tumor-Related Markers and Genetically Modified Rice Expressing Cry1Ab Protein in Sprague-Dawley Rats.

Author

Hajimohammadi, Bahador, Eslami, Gilda, Loni, Elahe, Ehrampoush, Mohammad Hassan, Moshtaghioun, Seyed Mohammad, Fallahzadeh, Hossein, Ardakani, Seyed Ali Yasini, Hosseini, Saeedeh Sadat, and Askari, Vahideh

Subjects
RICE, ANIMAL experimentation, RATS, TUMOR markers
Abstract

Genetically Modified (GM) foods are among the most important achievements of biotechnology. Given the safety importance of transgenic rice, this study was conducted to investigate the effect of GM rice consumption on serum concentrations of tumor markers in rats. In this experimental intervention, we used the blood serum samples from the Biobank taken from 60 males and 60 female Sprague-Dawley (SD) rats fed on three different diets, including rat's standard food, non-GM rice, and GM rice after 90 day. Tumor markers including Carcinogenic embryonic antigen (CEA), Alpha-Fito protein (AFP), Cancer Antigen 19-9 (CA19-9), Cancer Antigen 125 (CA125), and Cancer Antigen15-3 (CA15-3) were assessed by enzyme-linked immune sorbent assay (ELISA) method. Statistical analysis was conducted via SPSS software. The results show that the concentrations of tumor markers were within the normal range in the SD rats treated with diet, and since the concentration of tumor markers was lower than the acceptable index determined, according to the kit standard in both groups, no obvious carcinogenic effect was found. However, these findings are not enough to make a final decision regarding the safety assessment of GM rice consumption. [ABSTRACT FROM AUTHOR]

Published
2022
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