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1. Brain Perfusion MRI Findings in Patients with Behcet’s Disease

Author

Alpay Alkan, Asli Goktan, Yelda Karincaoglu, Suat Kamisli, Metin Dogan, Namik Oztanir, Nergiz Turan, and Ercan Kocakoc

Subjects
Technology, Medicine, Science
Abstract

Objective. To search brain perfusion MRI (pMRI) changes in Behcet’s disease (BD) with or without neurological involvement. Materials and Method. The pMRI were performed in 34 patients with BD and 16 healthy controls. Based on neurologic examination and post-contrast MRI, 12 patients were classified as Neuro-Behcet (group 1, NBD) and 22 patients as BD without neurological involvement (group 2). Mean transit time (MTT), time to peak (TTP), relative cerebral blood volume (rCBV), and relative cerebral blood flow (rCBF) were obtained and compared to those of healthy control group (group 3). Results. There was a significant difference in the MTT and rCBF within the pons and parietal cortex in groups 1 and 2. rCBV increased in cerebral pedicle in group 1 compared with groups 2 and 3. In the temporal lobe white matter, prolonged MTT and decreased rCBF were found in groups 1 and 2. In the corpus striatum, internal capsule, and periventricular white matter, rCBF increased in group 1 compared with group 3 and decreased in groups 1 and 2. Conclusion. Brain pMRI is a very sensitive method to detect brain involvement in patients with BD and aids the clinical diagnosis of NBD, especially in patients with negative MRI findings.

Published
2012
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2. Incidence of neuropathic pain in patients with thoracic disc pathologies presenting with chronic upper back pain and correlation of herniation grade with pain severity

Author

Asli Goktan and Emine Dundar Ahi

Subjects
medicine.medical_specialty, business.industry, Incidence, Incidence (epidemiology), Surgery, Correlation, Cross-Sectional Studies, Back Pain, Pain severity, Neuropathic pain, medicine, Back pain, Humans, Neuralgia, In patient, Neurology (clinical), medicine.symptom, business, Thoracic disc, Intervertebral Disc Displacement, Pain Measurement, Retrospective Studies
Abstract

To determine the incidence of neuropathic pain (NP) in patients with thoracic disc herniation (TDH) and to determine whether there is any correlation between pain severity and herniation grade.A total of 110 patients diagnosed with TDH with chronic non-specific thoracic spine pain were included in our cross-sectional observational study. Data including magnetic resonance imaging findings, bulging, protrusion, extrusion and sequestration were retrospectively analysed. We determined the incidence of NP in patients by administering the self report form Douleur Neuropathique 4 (DN4) questionnaire. Pain severity was assessed using Numeric Rating Scale scores.In our study, 79.1% of TDHs were located below the T7-8 level. The patients were divided into two subgroups on the basis of the results of the DN4 questionnaire: NP subgroup, 43 (39.1%), and non-NP subgroup, 67 (60.9%). Although there was no statistically significant association between presence of NP and herniation grade bulging, protrusion or sequestration (p0.05), the rate of herniation in the extrusion grade was statistically significantly higher in patients with NP than in those without NP (p=0.004). The pain severity of the patients with herniation grade extrusion was statistically higher than that of patients with other non-extrusion grades (p=0.035).TDH should be considered in patients with neuropathic chronic back, chest and abdominal pain. If the patient?s pain characteristics indicate NP, a diagnosis of TDH becomes more likely, considering that nearly 4 out of 10 patients with TDH have NP.

Published
2021

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