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33 results on '"Asna, Noam"'

6. A role of BPTF in viral oncogenicity delineated through studies of heritable Kaposi sarcoma.

Author

Yogev, Yuval, Schaffer, Moshe, Shlapobersky, Mark, Jean, Matan M., Wormser, Ohad, Drabkin, Max, Halperin, Daniel, Kassem, Riad, Livoff, Alejandro, Tsitrina, Alexandra A., Asna, Noam, and Birk, Ohad S.

Abstract

Kaposi sarcoma (KS), caused by Herpesvirus‐8 (HHV‐8; KSHV), shows sporadic, endemic, and epidemic forms. While familial clustering of KS was previously recorded, the molecular basis of hereditary predilection to KS remains largely unknown. We demonstrate through genetic studies that a dominantly inherited missense mutation in BPTF segregates with a phenotype of classical KS in multiple immunocompetent individuals in two families. Using an rKSHV.219‐infected CRISPR/cas9‐model, we show that BPTFI2012T mutant cells exhibit higher latent‐to‐lytic ratio, decreased virion production, increased LANA staining, and latent phenotype in viral transcriptomics. RNA‐sequencing demonstrated that KSHV infection dysregulated oncogenic‐like response and P53 pathways, MAPK cascade, and blood vessel development pathways, consistent with KS. BPTFI2012T also enriched pathways of viral genome regulation and replication, immune response, and chemotaxis, including downregulation of IFI16, SHFL HLAs, TGFB1, and HSPA5, all previously associated with KSHV infection and tumorigenesis. Many of the differentially expressed genes are regulated by Rel‐NF‐κB, which regulates immune processes, cell survival, and proliferation and is pivotal to oncogenesis. We thus demonstrate BPTF mutation‐mediated monogenic hereditary predilection of KSHV virus‐induced oncogenesis, and suggest BPTF as a drug target. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Oncology Treatments during the COVID-19 Pandemic in Israel: the ONCOR Study.

Author

Hirsh-Yechezkel, Galit, Chetrit, Angela, Avraham, Sivan Ben, Agbarya, Abed, Yakobson, Alexander, Asna, Noam, Bar-Sela, Gil, Ben-Aharon, Irit, Ben-Baruch, Noa Efrat, Berger, Raanan, Brenner, Ronen, Gottfried, Maya, Paluch-Shimon, Shani, Pfeffer, Raphael, Popovtzer, Aron, Ryvo, Larisa, Semenisty, Valeriya, Shai, Ayelet, Shulman, Katerina, and Zidan, Jamal

Published
2021

23. Assessing the effectiveness of Dead Sea products as prophylactic agents for acute radiochemotherapy-induced skin and mucosal toxicity in patients with head and neck cancers: a phase 2 study

Author

Diana, Matceyevsky, Neora Yaal, Hahoshen, Akiva, Vexler, Asna, Noam, Avi, Khafif, and Rami, Ben-Yosef

Subjects
Adult, Aged, 80 and over, Male, Mucositis, Mucous Membrane, Emollients, Oceans and Seas, Mouthwashes, Dermatitis, Middle Aged, Chemoprevention, Treatment Outcome, Head and Neck Neoplasms, Acute Disease, Humans, Female, Israel, Mineral Waters, Aged, Skin
Abstract

Mucositis and dermatitis are frequently encountered in patients treated with radiochemotherapy. Dead Sea products that contain minerals and other properties have proven effective in treating various skin diseases.To evaluate the effectiveness of Dead Sea products in reducing acute radiochemotherapy-induced side effects in patients with head and neck cancer.In this phase 2 study we compared the outcomes in 24 treated patients and 30 conventionally treated patients matched for age, tumor site, and type of treatment. The Dead Sea products comprised a mouthwash solution (Lenom) and a skin cream (Solaris) used three times daily for 1 week before, during, and up to 2 weeks after completion of radiotherapy. Mucositis and dermatitis were evaluated using common toxicity criteria.Thirteen treated patients (54%) had grade 1-2 and none had 3-4 mucositis, while 17 controls (57%) had grade 1-2 and 4 (13%) had grade 3-4 mucositis. Thirteen treated patients (54%) had grade 1-2 dermatitis; there was no instance of grade 3-4 dermatitis, while 11 patients in the control group (37%) had grade 1-2 and 5 (17%) had grade 3-4 dermatitis. More patients in the control arm needed a break than did patients in the treatment the control arm needed a break than did patients in the treatment arm (P = 0.034).The two Dead Sea products tested decreased skin and mucosal toxicity in head and neck cancer patients receiving radiochemotherapy.

Published
2007

31. [PRIMARY GASTRIC PLASMACYTOMA IN A BREAST CANCER MALE PATIENT].

Author

Asna N, Shlapobersky M, Schaffer M, Harkovsky T, Vaknine H, Mintz Y, Ohana G, and Livoff A

Subjects
Gastrectomy, Humans, Male, Breast Neoplasms, Male diagnosis, Breast Neoplasms, Male therapy, Plasmacytoma diagnosis, Plasmacytoma therapy, Stomach Neoplasms surgery, Stomach Neoplasms therapy
Abstract

Introduction: Plasmacytoma is a malignant tumor of the plasma cells. Extra-medullary plasmacytoma is rare and with an even lower incidence appears as a primary tumor of the stomach. Initial onset of the disease in the upper gastrointestinal tract is reported in the literature as just second to primary plasmacytomas of the head and neck system. The presenting symptoms are related to the organ involved and systemic symptoms can be weight loss, pain, bleeding and even fever. As this is a rare disease, there is no standard treatment and patients undergo endoscopic resection or chemotherapy with or without additional radiation. The prognosis of the disease depends on the possible future diagnosis of multiple myeloma which can be up to 50% within only a few years. We hereby report a case of a male patient with a past locally advanced breast cancer who was on prolonged adjuvant hormonal treatment. He developed a new symptom of melena and underwent a thorough evaluation including imaging and repeated biopsies from a large gastric lesion. The results were inconclusive mainly because of the differential diagnosis between breast cancer metastases and a new second primary malignancy. In view of a clinical deterioration and lack of diagnosis, an operation of radical gastrectomy was eventually performed only to surprisingly diagnose a rare hematologic disease of the stomach - gastric plasmacytoma. This diagnosis is rare in itself, especially having his previous male breast cancer and maternal multiple myeloma. The diagnostic procedure in this case had also provided the full treatment for his illness.

Published
2022

33. Primary radiation therapy for solitary chloroma of oral tongue.

Author

Asna N, Cohen Y, and Ben-Yosef R

Subjects
Aged, Biopsy, Bone Marrow Examination, Female, Humans, Myelodysplastic Syndromes complications, Radiotherapy Dosage, Sarcoma, Myeloid etiology, Sarcoma, Myeloid pathology, Tongue Neoplasms etiology, Tongue Neoplasms pathology, Treatment Outcome, Sarcoma, Myeloid radiotherapy, Tongue Neoplasms radiotherapy
Published
2003

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