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Your search keyword '"Asogwa, Nnaemeka Tobechukwu"' showing total 18 results
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18 results on '"Asogwa, Nnaemeka Tobechukwu"'

3. Correction: Experimental validation and molecular docking to explore the active components of cannabis in testicular function and sperm quality modulations in rats

Author

Nwonuma, Charles O., Nwatu, Victoria C., Mostafa‑Hedeab, Gomaa, Adeyemi, Oluyomi S., Alejolowo, Omokolade O., Ojo, Oluwafemi Adeleke, Adah, Sylvanus A., Awakan, Oluwakemi J., Okolie, Charles E., Asogwa, Nnaemeka Tobechukwu, Udofia, Inemesit A., Egharevba, Godshelp O., Aljarba, Nada H., Alkahtani, Saad, and Batiha, Gaber El‑Saber

Published
2022
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4. Experimental validation and molecular docking to explore the active components of cannabis in testicular function and sperm quality modulations in rats

Author

Nwonuma, Charles O., Nwatu, Victoria C., Mostafa-Hedeab, Gomaa, Adeyemi, Oluyomi S., Alejolowo, Omokolade O., Ojo, Oluwafemi Adeleke, Adah, Sylvanus A., Awakan, Oluwakemi J., Okolie, Charles E., Asogwa, Nnaemeka Tobechukwu, Inemesit, Udofia A., Egharevba, Godshelp O., Aljarba, Nada H., Alkahtani, Saad, and Batiha, Gaber El-Saber

Published
2022
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6. Hippocampal Degeneration and Behavioral Impairment During Alzheimer-Like Pathogenesis Involves Glutamate Excitotoxicity

Author

Olajide, Olayemi Joseph, Gbadamosi, Ismail Tayo, Yawson, Emmanuel Olusola, Arogundade, Tolulope, Lewu, Folashade Susan, Ogunrinola, Kehinde Yomi, Adigun, Oluwaseun Olaniyi, Bamisi, Olawande, Lambe, Ezra, Arietarhire, Leviticus Ogbenevurinrin, Oluyomi, Olushola Oladapo, Idowu, Olumayowa Kolawole, Kareem, Rukayat, Asogwa, Nnaemeka Tobechukwu, and Adeniyi, Philip Adeyemi

Published
2021
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7. Profiling the antidiabetic potential of GC–MS compounds identified from the methanolic extract of Spilanthes filicaulis : experimental and computational insight

Author

Ojo, Oluwafemi Adeleke, primary, Ogunlakin, Akingbolabo Daniel, additional, Gyebi, Gideon Ampoma, additional, Ayokunle, Damilare IyinKristi, additional, Odugbemi, Adeshina Isaiah, additional, Babatunde, Dare Ezekiel, additional, Akintunde, Emmanuel Adewuni, additional, Ezea, Samson Chukwuemeka, additional, Asogwa, Nnaemeka Tobechukwu, additional, Asaleye, Rotdelmwa Maimako, additional, and Ojo, Adebola Busola, additional

Published
2023
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9. Additional file 1 of Experimental validation and molecular docking to explore the active components of cannabis in testicular function and sperm quality modulations in rats

Author

Nwonuma, Charles O., Nwatu, Victoria C., Mostafa-Hedeab, Gomaa, Adeyemi, Oluyomi S., Alejolowo, Omokolade O., Ojo, Oluwafemi Adeleke, Adah, Sylvanus A., Awakan, Oluwakemi J., Okolie, Charles E., Asogwa, Nnaemeka Tobechukwu, Inemesit, Udofia A., Egharevba, Godshelp O., Aljarba, Nada H., Alkahtani, Saad, and Batiha, Gaber El-Saber

Abstract

Additional file 1. HPLC chromatogram of ethanolic leaf extract of cannabis.

Published
2022
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10. Antidiabetic Activity of Elephant Grass (Cenchrus Purpureus (Schumach.) Morrone) via Activation of PI3K/AkT Signaling Pathway, Oxidative Stress Inhibition, and Apoptosis in Wistar Rats

Author

Ojo, Oluwafemi Adeleke, primary, Oni, Abosede Itunuoluwa, additional, Grant, Susan, additional, Amanze, Jennifer, additional, Ojo, Adebola Busola, additional, Taiwo, Odunayo Anthonia, additional, Maimako, Rotdelmwa Filibus, additional, Evbuomwan, Ikponmwosa Owen, additional, Iyobhebhe, Matthew, additional, Nwonuma, Charles Obiora, additional, Osemwegie, Omorefosa, additional, Agboola, Anthonia Oluyemi, additional, Akintayo, Christopher, additional, Asogwa, Nnaemeka Tobechukwu, additional, Aljarba, Nada H., additional, Alkahtani, Saad, additional, Mostafa-Hedeab, Gomaa, additional, Batiha, Gaber El-Saber, additional, and Adeyemi, Oluyomi Stephen, additional

Published
2022
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11. Modulatory effect of cashew (Anacardium occidentale L.) nut supplemented diet on fertility activity of clomiphene citrate in male rats

Author

Akomolafe, Seun Funmilola, primary, Aina, Babatunde, additional, Bajulaye, Jumoke, additional, Ogundare, Iyadunni, additional, Olulade, Damola, additional, Adeniji, Rebecca, additional, Fatuase, Faith, additional, Olojo-Kosoko, Ayomide, additional, Ganiyu, Oboh, additional, and Asogwa, Nnaemeka Tobechukwu, additional

Published
2021
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14. Glucocorticoid receptor activation selectively influence performance of Wistar rats in Y-maze

Author

Amin Abdulbasit, Abolarinwa Bilikis Aderonke, Abdulmajeed Wahab Imam, Asogwa Nnaemeka Tobechukwu, Alli-oluwafuyi Abdul-Musawwir, Owoyele Victor Bamidele, Fii Stephen Michael, Olaseinde Folajimi, Adeyanju Oluwaseun Aremu, Amusa Shukurat Onaopemipo, Ibrahim Ridwan Babatunde, and Imam Aminu

Subjects
0301 basic medicine, medicine.medical_specialty, Elevated plus maze, Chemistry, Insulin, medicine.medical_treatment, Morris water navigation task, Stimulation, medicine.disease_cause, Pathology and Forensic Medicine, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Glucocorticoid receptor, Endocrinology, Physiology (medical), Internal medicine, medicine, Prefrontal cortex, 030217 neurology & neurosurgery, Dexamethasone, Oxidative stress, medicine.drug
Abstract

Glucocorticoid receptors (GR) are ubiquitously expressed in metazoans. Different and contrasting phenotypes have been reported upon their activation. This study investigated the behavioral phenotypes characteristic of GR stimulation in male Wistar rats. Rats in each of the four groups of rats received one of the following treatments: distilled water (control) or one of three doses of dexamethasone (treatment) injected intraperitoneally for 7 days. The Rats were afterwards subjected to the Y maze, the elevated plus maze (EPM), the Morris water maze (MWM), and the novel object recognition (NOR) test. At the end of the study, the animals were anesthetized and neural activity from the prefrontal cortex recorded. Blood was collected via cardiac puncture to evaluate the levels of plasma insulin and glucose, and the prefrontal cortexes excised to determine the levels of insulin, markers of oxidative stress, and calcium in the homogenate. This study showed that treatment with dexamethasone significantly reduced the total and percentage alternation in the Y maze, but had no significant effect on object recognition in the NOR test, long-term and short-term spatial memory in the MWM, or anxiety-like behavior in the EPM. Plasma and brain insulin and calcium levels were elevated moderately following treatment with the lowest dose of dexamethasone. All doses of dexamethasone decreased brain superoxide dismutase and increased lactate dehydrogenase levels. No significant change in neural activity was observed. This study shows that activation of glucocorticoid receptors differentially affects different behavioral paradigms and provides evidence for a role for glucocorticoids in mediating insulin function in the brain.

Published
2016

15. Modulatory effect of cashew (AnacardiumoccidentaleL.) nut supplemented diet on fertility activity of clomiphene citrate in male rats

Author

Akomolafe, Seun Funmilola, Aina, Babatunde, Bajulaye, Jumoke, Ogundare, Iyadunni, Olulade, Damola, Adeniji, Rebecca, Fatuase, Faith, Olojo-Kosoko, Ayomide, Ganiyu, Oboh, and Asogwa, Nnaemeka Tobechukwu

Abstract

Increasing concern has been expressed about the declining sperm count of humans and the potential fertility effects of clomiphene citrate, a synthetic oestrogen-antagonist on human reproductive health in the last few decades. This study aims to investigate the influence of cashew nut supplemented diet on fertility activity of clomiphene citrate in male rats.

Published
2021
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17. Cerebellar Molecular and Cellular Characterization in Rat Models of Alzheimer's Disease: Neuroprotective Mechanisms of Garcinia Biflavonoid Complex

Author

Olajide, Olayemi Joseph, primary, Ugbosanmi, Anita Temi, additional, Enaibe, Bernard Ufuoma, additional, Ogunrinola, Kehinde Yomi, additional, Lewu, Susan Folashade, additional, Asogwa, Nnaemeka Tobechukwu, additional, Akapa, Tosan, additional, Imam, Aminu, additional, Ibrahim, Abdulmumin, additional, Gbadamosi, Ismail Temitayo, additional, and Yawson, Emmanuel Olusola, additional

Published
2017
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18. Cerebellar Molecular and Cellular Characterization in Rat Models of Alzheimer's Disease: Neuroprotective Mechanisms of GarciniaBiflavonoid Complex

Author

Olajide, Olayemi Joseph, Ugbosanmi, Anita Temi, Enaibe, Bernard Ufuoma, Ogunrinola, Kehinde Yomi, Lewu, Susan Folashade, Asogwa, Nnaemeka Tobechukwu, Akapa, Tosan, Imam, Aminu, Ibrahim, Abdulmumin, Gbadamosi, Ismail Temitayo, and Yawson, Emmanuel Olusola

Abstract

Background:Recent evidences suggest that cerebellar degeneration may be associated with the development of Alzheimer's disease (AD). However, previous reports were mainly observational, lacking substantial characterization of cellular and molecular cerebellar features during AD progression. Purpose:This study is aimed at characterizing the cerebellum in rat models of AD and assessing the corresponding neuroprotective mechanisms of Garciniabiflavonoid complex (GBc). Methods:Male Wistar rats were grouped and treated alone or in combination with PBS (ad libitum)/day, corn oil (CO; 2 mL/kgBw/day), GBc (200 mg/kgBw/day), sodium azide (NaN3) (15 mg/kgBw/day) and aluminium chloride (AlCl3) (100 mg/kgBw/day). Groups A and B received PBS and CO, respectively; C received GBc; D received NaN3; E received AlCl3; F received NaN3then GBc subsequently; G received AlCl3then GBc subsequently; H received NaN3and GBc simultaneously while I received AlCl3and GBc simultaneously. Following treatments, cerebellar cortices were processed for histology, immunohistochemistry and colorimetric assays. Results:Our data revealed that cryptic granule neurons and pyknotic Purkinje cell bodies (characterized by short dendritic/axonal processes) correspond to indistinctly demarcated cerebellar layers in rats treated with AlCl3and NaN3. These correlates, with observed hypertrophic astrogliosis, increased the neurofilament deposition, depleted the antioxidant system-shown by expressed superoxide dismutase and glutathione peroxidase, and cerebellar glucose bioenergetics dysfunction-exhibited in assayed lactate dehydrogenase and glucose-6-phosphate dehydrogenase. We further showed that GBc reverses cerebellar degeneration through modulation of neurochemical signaling pathways and stressor molecules that underlie AD pathogenesis. Conclusion:Cellular, molecular and metabolic neurodegeneration within the cerebellum is associated with AlCl3and NaN3-induced AD while GBc significantly inhibits corresponding neurotoxicity and is more efficacious when pre-administered.

Published
2017
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