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199 results on '"Assenmacher, Charles‐Antoine"'

1. Nuclear Pleomorphism in Canine Cutaneous Mast Cell Tumors: Comparison of Reproducibility and Prognostic Relevance between Estimates, Manual Morphometry and Algorithmic Morphometry

Author

Haghofer, Andreas, Parlak, Eda, Bartel, Alexander, Donovan, Taryn A., Assenmacher, Charles-Antoine, Bolfa, Pompei, Dark, Michael J., Fuchs-Baumgartinger, Andrea, Klang, Andrea, Jäger, Kathrin, Klopfleisch, Robert, Merz, Sophie, Richter, Barbara, Schulman, F. Yvonne, Janout, Hannah, Ganz, Jonathan, Scharinger, Josef, Aubreville, Marc, Winkler, Stephan M., Kiupel, Matti, and Bertram, Christof A.

Subjects
Computer Science - Computer Vision and Pattern Recognition
Abstract

Variation in nuclear size and shape is an important criterion of malignancy for many tumor types; however, categorical estimates by pathologists have poor reproducibility. Measurements of nuclear characteristics (morphometry) can improve reproducibility, but manual methods are time consuming. The aim of this study was to explore the limitations of estimates and develop alternative morphometric solutions for canine cutaneous mast cell tumors (ccMCT). We assessed the following nuclear evaluation methods for measurement accuracy, reproducibility, and prognostic utility: 1) anisokaryosis (karyomegaly) estimates by 11 pathologists; 2) gold standard manual morphometry of at least 100 nuclei; 3) practicable manual morphometry with stratified sampling of 12 nuclei by 9 pathologists; and 4) automated morphometry using a deep learning-based segmentation algorithm. The study dataset comprised 96 ccMCT with available outcome information. The study dataset comprised 96 ccMCT with available outcome information. Inter-rater reproducibility of karyomegaly estimates was low ($\kappa$ = 0.226), while it was good (ICC = 0.654) for practicable morphometry of the standard deviation (SD) of nuclear size. As compared to gold standard manual morphometry (AUC = 0.839, 95% CI: 0.701 - 0.977), the prognostic value (tumor-specific survival) of SDs of nuclear area for practicable manual morphometry (12 nuclei) and automated morphometry were high with an area under the ROC curve (AUC) of 0.868 (95% CI: 0.737 - 0.991) and 0.943 (95% CI: 0.889 - 0.996), respectively. This study supports the use of manual morphometry with stratified sampling of 12 nuclei and algorithmic morphometry to overcome the poor reproducibility of estimates.

Published
2023

7. Combination HSCT and intravenous AAV-mediated gene therapy in a canine model proves pivotal for translation of Krabbe disease therapy

Author

Bradbury, Allison M., Bagel, Jessica, Swain, Gary, Miyadera, Keiko, Pesayco, Jill P., Assenmacher, Charles-Antoine, Brisson, Becky, Hendricks, Ian, Wang, Xiao H., Herbst, Zachary, Pyne, Nettie, Odonnell, Patricia, Shelton, G. Diane, Gelb, Michael, Hackett, Neil, Szabolcs, Paul, Vite, Charles H., and Escolar, Maria

Published
2024
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8. How Many Annotators Do We Need? -- A Study on the Influence of Inter-Observer Variability on the Reliability of Automatic Mitotic Figure Assessment

Author

Wilm, Frauke, Bertram, Christof A., Marzahl, Christian, Bartel, Alexander, Donovan, Taryn A., Assenmacher, Charles-Antoine, Becker, Kathrin, Bennett, Mark, Corner, Sarah, Cossic, Brieuc, Denk, Daniela, Dettwiler, Martina, Gonzalez, Beatriz Garcia, Gurtner, Corinne, Lehmbecker, Annika, Merz, Sophie, Plog, Stephanie, Schmidt, Anja, Smedley, Rebecca C., Tecilla, Marco, Thaiwong, Tuddow, Breininger, Katharina, Kiupel, Matti, Maier, Andreas, Klopfleisch, Robert, and Aubreville, Marc

Subjects
Computer Science - Computer Vision and Pattern Recognition
Abstract

Density of mitotic figures in histologic sections is a prognostically relevant characteristic for many tumours. Due to high inter-pathologist variability, deep learning-based algorithms are a promising solution to improve tumour prognostication. Pathologists are the gold standard for database development, however, labelling errors may hamper development of accurate algorithms. In the present work we evaluated the benefit of multi-expert consensus (n = 3, 5, 7, 9, 11) on algorithmic performance. While training with individual databases resulted in highly variable F$_1$ scores, performance was notably increased and more consistent when using the consensus of three annotators. Adding more annotators only resulted in minor improvements. We conclude that databases by few pathologists and high label accuracy may be the best compromise between high algorithmic performance and time investment., Comment: Due to data inconsistencies experiments had to be repeated with a reduced number of annotators (17 in version 1). All findings of the previous version were reproducible. 7 pages, 2 figures, accepted at BVM workshop 2021

Published
2020
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10. Figure S3 from Proton FLASH Radiotherapy Ameliorates Radiation-induced Salivary Gland Dysfunction and Oral Mucositis and Increases Survival in a Mouse Model of Head and Neck Cancer

Author

Chowdhury, Priyanka, primary, Velalopoulou, Anastasia, primary, Verginadis, Ioannis I., primary, Morcos, George, primary, Loo, Phoebe E., primary, Kim, Michele M., primary, Motlagh, Seyyedeh Azar Oliaei, primary, Shoniyozov, Khayrullo, primary, Diffenderfer, Eric S., primary, Ocampo, Emilio A., primary, Putt, Mary, primary, Assenmacher, Charles-Antoine, primary, Radaelli, Enrico, primary, Lu, Jiawei, primary, Qin, Ling, primary, Liu, Hengxi, primary, Leli, Nektaria Maria, primary, Girdhani, Swati, primary, Denef, Nicolas, primary, Vander Stappen, Francois, primary, Cengel, Keith A., primary, Busch, Theresa M., primary, Metz, James M., primary, Dong, Lei, primary, Lin, Alexander, primary, and Koumenis, Constantinos, primary

Published
2024
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11. Data from Proton FLASH Radiotherapy Ameliorates Radiation-induced Salivary Gland Dysfunction and Oral Mucositis and Increases Survival in a Mouse Model of Head and Neck Cancer

Author

Chowdhury, Priyanka, primary, Velalopoulou, Anastasia, primary, Verginadis, Ioannis I., primary, Morcos, George, primary, Loo, Phoebe E., primary, Kim, Michele M., primary, Motlagh, Seyyedeh Azar Oliaei, primary, Shoniyozov, Khayrullo, primary, Diffenderfer, Eric S., primary, Ocampo, Emilio A., primary, Putt, Mary, primary, Assenmacher, Charles-Antoine, primary, Radaelli, Enrico, primary, Lu, Jiawei, primary, Qin, Ling, primary, Liu, Hengxi, primary, Leli, Nektaria Maria, primary, Girdhani, Swati, primary, Denef, Nicolas, primary, Vander Stappen, Francois, primary, Cengel, Keith A., primary, Busch, Theresa M., primary, Metz, James M., primary, Dong, Lei, primary, Lin, Alexander, primary, and Koumenis, Constantinos, primary

Published
2024
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12. Supplementary Table 2 from Proton FLASH Radiotherapy Ameliorates Radiation-induced Salivary Gland Dysfunction and Oral Mucositis and Increases Survival in a Mouse Model of Head and Neck Cancer

Author

Chowdhury, Priyanka, primary, Velalopoulou, Anastasia, primary, Verginadis, Ioannis I., primary, Morcos, George, primary, Loo, Phoebe E., primary, Kim, Michele M., primary, Motlagh, Seyyedeh Azar Oliaei, primary, Shoniyozov, Khayrullo, primary, Diffenderfer, Eric S., primary, Ocampo, Emilio A., primary, Putt, Mary, primary, Assenmacher, Charles-Antoine, primary, Radaelli, Enrico, primary, Lu, Jiawei, primary, Qin, Ling, primary, Liu, Hengxi, primary, Leli, Nektaria Maria, primary, Girdhani, Swati, primary, Denef, Nicolas, primary, Vander Stappen, Francois, primary, Cengel, Keith A., primary, Busch, Theresa M., primary, Metz, James M., primary, Dong, Lei, primary, Lin, Alexander, primary, and Koumenis, Constantinos, primary

Published
2024
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13. Supplementary Table 1 from Proton FLASH Radiotherapy Ameliorates Radiation-induced Salivary Gland Dysfunction and Oral Mucositis and Increases Survival in a Mouse Model of Head and Neck Cancer

Author

Chowdhury, Priyanka, primary, Velalopoulou, Anastasia, primary, Verginadis, Ioannis I., primary, Morcos, George, primary, Loo, Phoebe E., primary, Kim, Michele M., primary, Motlagh, Seyyedeh Azar Oliaei, primary, Shoniyozov, Khayrullo, primary, Diffenderfer, Eric S., primary, Ocampo, Emilio A., primary, Putt, Mary, primary, Assenmacher, Charles-Antoine, primary, Radaelli, Enrico, primary, Lu, Jiawei, primary, Qin, Ling, primary, Liu, Hengxi, primary, Leli, Nektaria Maria, primary, Girdhani, Swati, primary, Denef, Nicolas, primary, Vander Stappen, Francois, primary, Cengel, Keith A., primary, Busch, Theresa M., primary, Metz, James M., primary, Dong, Lei, primary, Lin, Alexander, primary, and Koumenis, Constantinos, primary

Published
2024
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14. Proton FLASH radiotherapy ameliorates radiation-induced salivary gland dysfunction and oral mucositis and increases survival in a mouse model of head and neck cancer

Author

Chowdhury, Priyanka, primary, Velalopoulou, Anastasia, additional, Verginadis, Ioannis I., additional, Morcos, George, additional, Loo, Phoebe E., additional, Kim, Michele M., additional, Motlagh, Seyyedeh Azar Oliaei, additional, Shoniyozov, Khayrullo, additional, Diffenderfer, Eric S., additional, Ocampo, Emilio A., additional, Putt, Mary, additional, Assenmacher, Charles-Antoine, additional, Radaelli, Enrico, additional, Lu, Jiawei, additional, Qin, Ling, additional, Liu, Hengxi, additional, Leli, Nektaria Maria, additional, Girdhani, Swati, additional, Denef, Nicolas, additional, Vander Stappen, Francois, additional, Cengel, Keith A., additional, Busch, Theresa M., additional, Metz, James M., additional, Dong, Lei, additional, Lin, Alexander, additional, and Koumenis, Constantinos, additional

Published
2024
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16. Influence of Inter-Annotator Variability on Automatic Mitotic Figure Assessment

Author

Wilm, Frauke, Bertram, Christof A., Marzahl, Christian, Bartel, Alexander, Donovan, Taryn A., Assenmacher, Charles-Antoine, Becker, Kathrin, Bennett, Mark, Corner, Sarah, Cossic, Brieuc, Denk, Daniela, Dettwiler, Martina, Gonzalez, Beatriz Garcia, Gurtner, Corinne, Heier, Annabelle, Lehmbecker, Annika, Merz, Sophie, Plog, Stephanie, Schmidt, Anja, Sebastian, Franziska, Smedley, Rebecca C., Tecilla, Marco, Thaiwong, Tuddow, Breininger, Katharina, Kiupel, Matti, Maier, Andreas, Klopfleisch, Robert, Aubreville, Marc, Gesellschaft für Informatik e.V. (GI), Palm, Christoph, editor, Deserno, Thomas M., editor, Handels, Heinz, editor, Maier, Andreas, editor, Maier-Hein, Klaus, editor, and Tolxdorff, Thomas, editor

Published
2021
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17. Proton radiation boosts the efficacy of mesothelin-targeting chimeric antigen receptor T cell therapy in pancreatic cancer.

Author

Amit, Uri, Uslu, Ugur, Verginadis, Ioannis I., Kim, Michele M., Oliaei Motlagh, Seyyedeh Azar, Diffenderfer, Eric S., Assenmacher, Charles-Antoine, Bicher, Sandra, Atoche, Sebastian J., Ben-Josef, Edgar, Young, Regina M., June, Carl H., and Koumenis, Constantinos

Subjects
MYELOID-derived suppressor cells, CHIMERIC antigen receptors, T cells, PANCREATIC duct, RADIOTHERAPY
Abstract

Pancreatic ductal adenocarcinoma (PDAC) represents a challenge in oncology, with limited treatment options for advanced-stage patients. Chimeric antigen receptor T cell (CAR T) therapy targeting mesothelin (MSLN) shows promise, but challenges such as the hostile immunosuppressive tumor microenvironment (TME) hinder its efficacy. This study explores the synergistic potential of combining proton radiation therapy (RT) with MSLN-targeting CAR T therapy in a syngeneic PDAC model. Proton RT significantly increased MSLN expression in tumor cells and caused a significant increase in CAR T cell infiltration into tumors. The combination therapy reshaped the immunosuppressive TME, promoting antitumorigenic M1 polarized macrophages and reducing myeloid-derived suppressor cells (MDSC). In a flank PDAC model, the combination therapy demonstrated superior attenuation of tumor growth and improved survival compared to individual treatments alone. In an orthotopic PDAC model treated with image-guided proton RT, tumor growth was significantly reduced in the combination group compared to the RT treatment alone. Further, the combination therapy induced an abscopal effect in a dual-flank tumor model, with increased serum interferon-γ levels and enhanced proliferation of extratumoral CAR T cells. In conclusion, combining proton RT with MSLN-targeting CAR T therapy proves effective in modulating the TME, enhancing CAR T cell trafficking, and exerting systemic antitumor effects. Thus, this combinatorial approach could present a promising strategy for improving outcomes in unresectable PDAC. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Humanization with CD34-positive hematopoietic stem cells in NOG-EXL mice results in improved long-term survival and less severe myeloid cell hyperactivation phenotype relative to NSG-SGM3 mice.

Author

Willis, Elinor, Verrelle, Jillian, Banerjee, Esha, Assenmacher, Charles-Antoine, Tarrant, James C., Skuli, Nicholas, Jacobson, Moriah L., O'Rouke, Donald M., Binder, Zev A., and Radaelli, Enrico

Subjects
MYELOID cells, HEMATOPOIETIC stem cells, MACROPHAGE activation syndrome, KOUNIS syndrome, MICE, TISSUE expansion, PHENOTYPES
Abstract

NSG-SGM3 and NOG-EXL mice combine severe immunodeficiency with transgenic expression of human myeloid stimulatory cytokines, resulting in marked expansion of myeloid populations upon humanization with CD34+ hematopoietic stem cells (HSCs). Humanized NSG-SGM3 mice typically develop a lethal macrophage activation syndrome and mast cell hyperplasia that limit their use in long-term studies (e.g., humanization followed by tumor xenotransplantation). It is currently unclear to what extent humanized NOG-EXL mice suffer from the same condition observed in humanized NSG-SGM3 mice. We compared the effects of human CD34+ HSC engraftment in these two strains in an orthotopic patient-derived glioblastoma model. NSG-SGM3 mice humanized in-house were compared to NOG-EXL mice humanized in-house and commercially available humanized NOG-EXL mice. Mice were euthanized at humane or study endpoints, and complete pathological assessments were performed. A semiquantitative multiparametric clinicopathological scoring system was developed to characterize chimeric myeloid cell hyperactivation (MCH) syndrome. NSG-SGM3 mice were euthanized at 16 weeks after humanization because of severe deterioration of clinical conditions. Humanized NOG-EXL mice survived to the study endpoint at 22 weeks after humanization and showed less-severe MCH phenotypes than NSG-SGM3 mice. Major differences included the lack of mast cell expansion and limited tissue/organ involvement in NOG-EXL mice compared to NSG-SGM3 mice. Engraftment of human lymphocytes, assessed by immunohistochemistry, was similar in the two strains. The longer survival and decreased MCH phenotype severity in NOG-EXL mice enabled their use in a tumor xenotransplantation study. The NOG-EXL model is better suited than the NSG-SGM3 model for immuno-oncology studies requiring long-term survival after humanization. [ABSTRACT FROM AUTHOR]

Published
2024
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19. A TNF-IL-1 circuit controls Yersinia within intestinal pyogranulomas

Author

Matsuda, Rina, primary, Sorobetea, Daniel, additional, Zhang, Jenna, additional, Peterson, Stefan T., additional, Grayczyk, James P., additional, Yost, Winslow, additional, Apenes, Nicolai, additional, Kovalik, Maria E., additional, Herrmann, Beatrice, additional, O’Neill, Rosemary J., additional, Bohrer, Andrea C., additional, Lanza, Matthew, additional, Assenmacher, Charles-Antoine, additional, Mayer-Barber, Katrin D., additional, Shin, Sunny, additional, and Brodsky, Igor E., additional

Published
2024
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20. RNF170 frameshift deletion in Miniature American Shepherd dogs with neuroaxonal dystrophy provides a naturally occurring model for human RNF170 phenotypic spectrum

Author

Cook, Shawna R., primary, Schwarz, Cleo, additional, Guevar, Julien, additional, Assenmacher, Charles-Antoine, additional, Sheehy, Maeve, additional, Fanzone, Nathan, additional, Church, Molly E., additional, Murgiano, Leonardo, additional, Casal, Margret L., additional, Jagannathan, Vidhya, additional, Gutierrez-Quintana, Rodrigo, additional, Lowrie, Mark, additional, Steffen, Frank, additional, Leeb, Tosso, additional, and Ekenstedt, Kari J., additional

Published
2024
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23. Automated Nuclear Morphometry: A Deep Learning Approach for Prognostication in Canine Pulmonary Carcinoma to Enhance Reproducibility.

Author

Glahn, Imaine, Haghofer, Andreas, Donovan, Taryn A., Degasperi, Brigitte, Bartel, Alexander, Kreilmeier-Berger, Theresa, Hyndman, Philip S., Janout, Hannah, Assenmacher, Charles-Antoine, Bartenschlager, Florian, Bolfa, Pompei, Dark, Michael J., Klang, Andrea, Klopfleisch, Robert, Merz, Sophie, Richter, Barbara, Schulman, F. Yvonne, Ganz, Jonathan, Scharinger, Josef, and Aubreville, Marc

Subjects
DEEP learning, MORPHOMETRICS, NUCLEAR shapes, CARCINOMA, PROGNOSIS, PROGNOSTIC tests
Abstract

Simple Summary: We investigated a new method for diagnosing and predicting outcomes in canine pulmonary carcinoma. We developed a deep learning-based algorithm that accurately detects tumor nuclei and subsequently measures size and shape parameters. The variation in nuclear size and shape (nuclear pleomorphism) is a crucial malignancy criterion used in the current grading system for canine pulmonary carcinoma. Pathologists currently evaluate it and classify it according to a three-tier system. Manual morphometry is a more objective approach where tumor nuclei are individually encircled and analyzed. This task can be easily performed by an algorithm. Our algorithm's accuracy in correctly detecting and segmenting tumor nuclei was considered good when compared to manual morphometry. By comparing automated morphometry with conventional prognostic tests, such as pathologists' estimates, mitotic count, histological grading, and clinical staging, we found that our approach was equally accurate in terms of prognostic value. The algorithm's advantage lies in its high reproducibility and efficiency. Automated evaluation of nuclear pleomorphism can enhance the efficiency and reliability of canine pulmonary carcinoma diagnosis and grading, effectively addressing issues of inter-observer reproducibility. However, further optimization of the algorithm and validation with a larger study group is necessary to confirm our findings. The integration of deep learning-based tools into diagnostic workflows is increasingly prevalent due to their efficiency and reproducibility in various settings. We investigated the utility of automated nuclear morphometry for assessing nuclear pleomorphism (NP), a criterion of malignancy in the current grading system in canine pulmonary carcinoma (cPC), and its prognostic implications. We developed a deep learning-based algorithm for evaluating NP (variation in size, i.e., anisokaryosis and/or shape) using a segmentation model. Its performance was evaluated on 46 cPC cases with comprehensive follow-up data regarding its accuracy in nuclear segmentation and its prognostic ability. Its assessment of NP was compared to manual morphometry and established prognostic tests (pathologists' NP estimates (n = 11), mitotic count, histological grading, and TNM-stage). The standard deviation (SD) of the nuclear area, indicative of anisokaryosis, exhibited good discriminatory ability for tumor-specific survival, with an area under the curve (AUC) of 0.80 and a hazard ratio (HR) of 3.38. The algorithm achieved values comparable to manual morphometry. In contrast, the pathologists' estimates of anisokaryosis resulted in HR values ranging from 0.86 to 34.8, with slight inter-observer reproducibility (k = 0.204). Other conventional tests had no significant prognostic value in our study cohort. Fully automated morphometry promises a time-efficient and reproducible assessment of NP with a high prognostic value. Further refinement of the algorithm, particularly to address undersegmentation, and application to a larger study population are required. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Antigen-specific B cell depletion for precision therapy of mucosal pemphigus vulgaris

Author

Lee, Jinmin, Lundgren, Daniel K., Mao, Xuming, Manfredo-Vieira, Silvio, Nunez-Cruz, Selene, Williams, Erik F., Assenmacher, Charles-Antoine, Radaelli, Enrico, Oh, Sangwook, Wang, Baomei, Ellebrecht, Christoph T., Fraietta, Joseph A., Milone, Michael C., and Payne, Aimee S.

Subjects
Pemphigus -- Development and progression -- Care and treatment -- Genetic aspects, Gene expression -- Health aspects, Cellular therapy -- Methods -- Patient outcomes, Autoantigens -- Health aspects, Health care industry
Abstract

Desmoglein 3 chimeric autoantibody receptor T cells (DSG3-CAART) expressing the pemphigus vulgaris (PV) autoantigen DSG3 fused to CD137-CD3[zeta] signaling domains, represent a precision cellular immunotherapy approach for antigen-specific B cell depletion. Here, we present definitive preclinical studies enabling a first-in-human trial of DSG3-CAART for mucosal PV. DSG3-CAART specifically lysed human anti-DSG3 B cells from PV patients and demonstrated activity consistent with a threshold dose in vivo, resulting in decreased target cell burden, decreased serum and tissue-bound autoantibodies, and increased DSG3-CAART engraftment. In a PV active immune model with physiologic anti-DSG3 IgG levels, DSG3-CAART inhibited antibody responses against pathogenic DSG3 epitopes and autoantibody binding to epithelial tissues, leading to clinical and histologic resolution of blisters. DSG3 autoantibodies stimulated DSG3-CAART IFN-[gamma] secretion and homotypic clustering, consistent with an activated phenotype. Toxicology screens using primary human cells and high-throughput membrane proteome arrays did not identify off-target cytotoxic interactions. These preclinical data guided the trial design for DSG3-CAART and may help inform CAART preclinical development for other antibody-mediated diseases., Introduction Chimeric antigen receptor (CAR) T cells targeting CD19 have proven clinical ability to induce durable remission of B cell cancers (1-3), underscoring the potential of genetically engineered T cells [...]

Published
2020
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25. Combination hematopoietic stem cell transplantation and intravenous AAVrh10-mediated gene therapy in a canine model proves pivotal for translation of Krabbe disease therapy.

Author

Bradbury, Allison M., primary, Bagel, Jessica, additional, Swain, Gary, additional, Miyadera, Keiko, additional, Pesayco, Jill P., additional, Assenmacher, Charles-Antoine, additional, Brisson, Becky, additional, Hendricks, Ian, additional, Wang, Xiao H., additional, Herbst, Zachary, additional, Pyne, Nettie, additional, Odonnell, Patricia, additional, Shelton, G. Diane, additional, Gelb, Michael, additional, Hackett, Neil, additional, Szabolcs, Paul, additional, Vite, Charles H., additional, and Escolar, Maria, additional

Published
2023
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28. MODL-10. SEVERELY IMMUNODEFICIENT NOG-EXL MICE ALLOW FOR HUMANIZATION AND DEVELOPMENT OF A HUMAN GLIOBLASTOMA-DERIVED TUMOR MICROENVIRONMENT

Author

Binder, Zev, primary, Lamrani, Lamia, additional, Secreto, Anthony, additional, Skuli, Nicholas, additional, Jacobson, Moriah, additional, Assenmacher, Charles-Antoine, additional, Willis, Elinor, additional, Radaelli, Enrico, additional, O'Rourke, Donald M, additional, Alanio, Cecile, additional, and Nasrallah, MacLean P, additional

Published
2023
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30. 5 Severely immunodeficient NOG-EXL mice allow for humanization and development of a human glioblastoma-derived tumor microenvironment

Author

Binder, Zev, primary, Lamrani, Lamia, additional, Secreto, Anthony, additional, Skuli, Nicholas, additional, Jacobson, Moriah, additional, Assenmacher, Charles-Antoine, additional, Willis, Elinor, additional, Radaelli, Enrico, additional, O’Rourke, Donald, additional, Alanio, Cecile, additional, and Nasrallah, Maclean, additional

Published
2023
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31. 261 Synergistic antitumor effects of mouse mesothelin-directed CAR (mmeso-CAR) T cells and αCD40 in a syngeneic model of PDAC

Author

Golinelli, Giulia, primary, Fan, Ting-Jia, additional, Gabunia, Khatuna, additional, Reff, Jordan, additional, Mai, David, additional, Johnson, Omar, additional, Ferraro, Zachary, additional, Song, Decheng, additional, Gupta, Aasha, additional, Deshmukh, Mansi, additional, Assenmacher, Charles-Antoine, additional, Radaelli, Enrico, additional, Martinez, Daniel, additional, Rech, Andrew, additional, Fraietta, Joseph A, additional, Xu, He N, additional, Wilson, Wesley V, additional, Tchou, Julia C, additional, Levine, Bruce L, additional, Young, Regina M, additional, Scholler, John, additional, and June, Carl H, additional

Published
2023
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32. Influence of Inter-Annotator Variability on Automatic Mitotic Figure Assessment

Author

Wilm, Frauke, primary, Bertram, Christof A., additional, Marzahl, Christian, additional, Bartel, Alexander, additional, Donovan, Taryn A., additional, Assenmacher, Charles-Antoine, additional, Becker, Kathrin, additional, Bennett, Mark, additional, Corner, Sarah, additional, Cossic, Brieuc, additional, Denk, Daniela, additional, Dettwiler, Martina, additional, Gonzalez, Beatriz Garcia, additional, Gurtner, Corinne, additional, Heier, Annabelle, additional, Lehmbecker, Annika, additional, Merz, Sophie, additional, Plog, Stephanie, additional, Schmidt, Anja, additional, Sebastian, Franziska, additional, Smedley, Rebecca C., additional, Tecilla, Marco, additional, Thaiwong, Tuddow, additional, Breininger, Katharina, additional, Kiupel, Matti, additional, Maier, Andreas, additional, Klopfleisch, Robert, additional, and Aubreville, Marc, additional

Published
2021
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35. Targeting cardiac fibrosis with engineered T cells

Author

Aghajanian, Haig, Kimura, Toru, Rurik, Joel G., Hancock, Aidan S., Leibowitz, Michael S., Li, Li, Scholler, John, Monslow, James, Lo, Albert, Han, Wei, Wang, Tao, Bedi, Kenneth, Morley, Michael P., Linares Saldana, Ricardo A., Bolar, Nikhita A., McDaid, Kendra, Assenmacher, Charles-Antoine, Smith, Cheryl L., Wirth, Dagmar, June, Carl H., Margulies, Kenneth B., Jain, Rajan, Puré, Ellen, Albelda, Steven M., and Epstein, Jonathan A.

Published
2019
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37. A TNF-IL-1 circuit controlsYersiniawithin intestinal granulomas

Author

Matsuda, Rina, primary, Daniel, Sorobetea, additional, Zhang, Jenna, additional, Peterson, Stefan T., additional, Grayczyk, James P., additional, Herrmann, Beatrice, additional, Yost, Winslow, additional, O’Neill, Rosemary, additional, Bohrer, Andrea C., additional, Lanza, Matthew, additional, Assenmacher, Charles-Antoine, additional, Mayer-Barber, Katrin D., additional, Shin, Sunny, additional, and Brodsky, Igor E., additional

Published
2023
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38. Tumor-restrictive type III collagen in the breast cancer microenvironment: prognostic and therapeutic implications

Author

Volk, Susan, primary, Brisson, Becky, additional, Dekky, Bassil, additional, Berger, Ashton, additional, Mauldin, Elizabeth, additional, Loebel, Claudia, additional, Yen, William, additional, Stewart, Daniel, additional, Gillette, Deborah, additional, Assenmacher, Charles-Antoine, additional, Cukierman, Edna, additional, Burdick, Jason, additional, and Borges, Virginia, additional

Published
2023
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39. Advanced precision modeling reveals divergent responses of hepatocellular carcinoma to combinatorial immunotherapy

Author

Liu, Jinping, primary, Cheng, Lan, additional, El‐Mekkoussi, Hilana, additional, Assenmacher, Charles‐Antoine, additional, Lee, Michelle Y. Y., additional, Jaffe, Danielle R., additional, Garvin‐Darby, Kaisha, additional, Morgan, Ashleigh, additional, Manduchi, Elisabetta, additional, Schug, Jonathan, additional, and Kaestner, Klaus H., additional

Published
2023
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40. Supplementary Table 1 from Tumor-Suppressive and Immune-Stimulating Roles of Cholesterol 25-hydroxylase in Pancreatic Cancer Cells

Author

McBrearty, Noreen, primary, Cho, Christina, primary, Chen, Jinyun, primary, Zahedi, Farima, primary, Peck, Amy R., primary, Radaelli, Enrico, primary, Assenmacher, Charles-Antoine, primary, Pavlak, Clarice, primary, Devine, Anne, primary, Yu, Pengfei, primary, Lu, Zhen, primary, Zhang, Hongru, primary, Li, Jinyang, primary, Pitarresi, Jason R., primary, Astsaturov, Igor, primary, Cukierman, Edna, primary, Rustgi, Anil K., primary, Stanger, Ben Z., primary, Rui, Hallgeir, primary, and Fuchs, Serge Y., primary

Published
2023
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41. Supplementary Figures 1-6 from Tumor-Suppressive and Immune-Stimulating Roles of Cholesterol 25-hydroxylase in Pancreatic Cancer Cells

Author

McBrearty, Noreen, primary, Cho, Christina, primary, Chen, Jinyun, primary, Zahedi, Farima, primary, Peck, Amy R., primary, Radaelli, Enrico, primary, Assenmacher, Charles-Antoine, primary, Pavlak, Clarice, primary, Devine, Anne, primary, Yu, Pengfei, primary, Lu, Zhen, primary, Zhang, Hongru, primary, Li, Jinyang, primary, Pitarresi, Jason R., primary, Astsaturov, Igor, primary, Cukierman, Edna, primary, Rustgi, Anil K., primary, Stanger, Ben Z., primary, Rui, Hallgeir, primary, and Fuchs, Serge Y., primary

Published
2023
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42. Data from Tumor-Suppressive and Immune-Stimulating Roles of Cholesterol 25-hydroxylase in Pancreatic Cancer Cells

Author

McBrearty, Noreen, primary, Cho, Christina, primary, Chen, Jinyun, primary, Zahedi, Farima, primary, Peck, Amy R., primary, Radaelli, Enrico, primary, Assenmacher, Charles-Antoine, primary, Pavlak, Clarice, primary, Devine, Anne, primary, Yu, Pengfei, primary, Lu, Zhen, primary, Zhang, Hongru, primary, Li, Jinyang, primary, Pitarresi, Jason R., primary, Astsaturov, Igor, primary, Cukierman, Edna, primary, Rustgi, Anil K., primary, Stanger, Ben Z., primary, Rui, Hallgeir, primary, and Fuchs, Serge Y., primary

Published
2023
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44. Figure SF6 from FLASH Proton Radiotherapy Spares Normal Epithelial and Mesenchymal Tissues While Preserving Sarcoma Response

Author

Velalopoulou, Anastasia, primary, Karagounis, Ilias V., primary, Cramer, Gwendolyn M., primary, Kim, Michele M., primary, Skoufos, Giorgos, primary, Goia, Denisa, primary, Hagan, Sarah, primary, Verginadis, Ioannis I., primary, Shoniyozov, Khayrullo, primary, Chiango, June, primary, Cerullo, Michelle, primary, Varner, Kelley, primary, Yao, Lutian, primary, Qin, Ling, primary, Hatzigeorgiou, Artemis G., primary, Minn, Andy J., primary, Putt, Mary, primary, Lanza, Matthew, primary, Assenmacher, Charles-Antoine, primary, Radaelli, Enrico, primary, Huck, Jennifer, primary, Diffenderfer, Eric, primary, Dong, Lei, primary, Metz, James, primary, Koumenis, Constantinos, primary, Cengel, Keith A., primary, Maity, Amit, primary, and Busch, Theresa M., primary

Published
2023
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45. Table ST1 from FLASH Proton Radiotherapy Spares Normal Epithelial and Mesenchymal Tissues While Preserving Sarcoma Response

Author

Velalopoulou, Anastasia, primary, Karagounis, Ilias V., primary, Cramer, Gwendolyn M., primary, Kim, Michele M., primary, Skoufos, Giorgos, primary, Goia, Denisa, primary, Hagan, Sarah, primary, Verginadis, Ioannis I., primary, Shoniyozov, Khayrullo, primary, Chiango, June, primary, Cerullo, Michelle, primary, Varner, Kelley, primary, Yao, Lutian, primary, Qin, Ling, primary, Hatzigeorgiou, Artemis G., primary, Minn, Andy J., primary, Putt, Mary, primary, Lanza, Matthew, primary, Assenmacher, Charles-Antoine, primary, Radaelli, Enrico, primary, Huck, Jennifer, primary, Diffenderfer, Eric, primary, Dong, Lei, primary, Metz, James, primary, Koumenis, Constantinos, primary, Cengel, Keith A., primary, Maity, Amit, primary, and Busch, Theresa M., primary

Published
2023
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46. Supplemental Methods from FLASH Proton Radiotherapy Spares Normal Epithelial and Mesenchymal Tissues While Preserving Sarcoma Response

Author

Velalopoulou, Anastasia, primary, Karagounis, Ilias V., primary, Cramer, Gwendolyn M., primary, Kim, Michele M., primary, Skoufos, Giorgos, primary, Goia, Denisa, primary, Hagan, Sarah, primary, Verginadis, Ioannis I., primary, Shoniyozov, Khayrullo, primary, Chiango, June, primary, Cerullo, Michelle, primary, Varner, Kelley, primary, Yao, Lutian, primary, Qin, Ling, primary, Hatzigeorgiou, Artemis G., primary, Minn, Andy J., primary, Putt, Mary, primary, Lanza, Matthew, primary, Assenmacher, Charles-Antoine, primary, Radaelli, Enrico, primary, Huck, Jennifer, primary, Diffenderfer, Eric, primary, Dong, Lei, primary, Metz, James, primary, Koumenis, Constantinos, primary, Cengel, Keith A., primary, Maity, Amit, primary, and Busch, Theresa M., primary

Published
2023
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49. sj-pdf-2-vet-10.1177_03009858231151403 – Supplemental material for Spontaneous early-onset neurodegeneration in the brainstem and spinal cord of NSG, NOG, and NXG mice

Author

Finesso, Giovanni, Willis, Elinor, Tarrant, James Carmine, Lanza, Matthew, Sprengers, Justin, Verrelle, Jillian, Banerjee, Esha, Hermans, Els, Assenmacher, Charles-Antoine, and Radaelli, Enrico

Subjects
70706 Veterinary Medicine, FOS: Clinical medicine, FOS: Veterinary sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental material, sj-pdf-2-vet-10.1177_03009858231151403 for Spontaneous early-onset neurodegeneration in the brainstem and spinal cord of NSG, NOG, and NXG mice by Giovanni Finesso, Elinor Willis, James Carmine Tarrant, Matthew Lanza, Justin Sprengers, Jillian Verrelle, Esha Banerjee, Els Hermans, Charles-Antoine Assenmacher and Enrico Radaelli in Veterinary Pathology

Published
2023
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50. The IAP antagonist birinapant enhances chimeric antigen receptor T cell therapy for glioblastoma by overcoming antigen heterogeneity

Author

Song, Edward Z., primary, Wang, Xin, additional, Philipson, Benjamin I., additional, Zhang, Qian, additional, Thokala, Radhika, additional, Zhang, Logan, additional, Assenmacher, Charles-Antoine, additional, Binder, Zev A., additional, Ming, Guo-li, additional, O’Rourke, Donald M., additional, Song, Hongjun, additional, and Milone, Michael C., additional

Published
2022
Full Text
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