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2. Supplementary Data-Combination Response from An Unbiased Oncology Compound Screen to Identify Novel Combination Strategies

Author

Stuart D. Shumway, Andrew Bloecher, Theresa Zhang, Christopher Winter, Brian B. Haines, Razvan Cristescu, William Arthur, Andrey Loboda, Serguei Lejnine, Astrid Kral, Jing Li, Yaping Liu, Brian Roberts, Melissa Chenard, Igor Feldman, Yair Benita, and Jennifer O'Neil

Abstract

raw combination response data; response is represented as fractional viability

Published
2023
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4. Supplementary Figure 2. Experiment that was used to select drug concentrations for combination screen. from An Unbiased Oncology Compound Screen to Identify Novel Combination Strategies

Author

Stuart D. Shumway, Andrew Bloecher, Theresa Zhang, Christopher Winter, Brian B. Haines, Razvan Cristescu, William Arthur, Andrey Loboda, Serguei Lejnine, Astrid Kral, Jing Li, Yaping Liu, Brian Roberts, Melissa Chenard, Igor Feldman, Yair Benita, and Jennifer O'Neil

Abstract

We ran 8 titration point curves (shown in gray) and then picked 4 concentration points that cover best the response curve for all cell lines (shown in red). The first point is the top plateau, the last is the bottom plateau and the other 2 are in between.

Published
2023
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5. Supplementary Data-Single Agent Response from An Unbiased Oncology Compound Screen to Identify Novel Combination Strategies

Author

Stuart D. Shumway, Andrew Bloecher, Theresa Zhang, Christopher Winter, Brian B. Haines, Razvan Cristescu, William Arthur, Andrey Loboda, Serguei Lejnine, Astrid Kral, Jing Li, Yaping Liu, Brian Roberts, Melissa Chenard, Igor Feldman, Yair Benita, and Jennifer O'Neil

Abstract

raw single agent response data; response is represented as fractional viability

Published
2023
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6. Supplementary Figure 1. Hierarchical clustering of response to single agent treatments. from An Unbiased Oncology Compound Screen to Identify Novel Combination Strategies

Author

Stuart D. Shumway, Andrew Bloecher, Theresa Zhang, Christopher Winter, Brian B. Haines, Razvan Cristescu, William Arthur, Andrey Loboda, Serguei Lejnine, Astrid Kral, Jing Li, Yaping Liu, Brian Roberts, Melissa Chenard, Igor Feldman, Yair Benita, and Jennifer O'Neil

Abstract

Hierarchical clustering was performed on the response data across the cell line panel to the single agent treatments. Drugs with similar mechanisms of action clustered together.

Published
2023
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7. Supplemental Table 1. Thirty-nine cell lines used in combination screen. from An Unbiased Oncology Compound Screen to Identify Novel Combination Strategies

Author

Stuart D. Shumway, Andrew Bloecher, Theresa Zhang, Christopher Winter, Brian B. Haines, Razvan Cristescu, William Arthur, Andrey Loboda, Serguei Lejnine, Astrid Kral, Jing Li, Yaping Liu, Brian Roberts, Melissa Chenard, Igor Feldman, Yair Benita, and Jennifer O'Neil

Abstract

RAS mutation/signature does not predict response to mTOR/Wee1 combination.

Published
2023
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8. Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus

Author

Astrid Kral, Herman Yeger, Jerry Pelletier, Elise A. Rose, Carol Jones, William H. Lewis, Caryn Y. Ito, Daniel A. Haber, David E. Housman, Katherine M. Call, Alan Buckler, and Thomas M Glaser

Subjects
Molecular Sequence Data, Restriction Mapping, EGR1, Locus (genetics), Biology, Hybrid Cells, Wilms Tumor, General Biochemistry, Genetics and Molecular Biology, Cell Line, Sequence Homology, Nucleic Acid, Gene expression, Metalloproteins, medicine, Humans, Amino Acid Sequence, Cloning, Molecular, Gene, Gene Library, Genetics, Zinc finger, Base Sequence, Chromosomes, Human, Pair 11, Nucleic acid sequence, Chromosome Mapping, Wilms' tumor, DNA, medicine.disease, Cosmids, Molecular biology, Wilms Tumor Protein, Kidney Neoplasms, DNA-Binding Proteins, Blotting, Southern, Zinc, Genes, DNA Probes
Abstract

We have isolated a series of genomic and cDNA clones mapping within the boundaries of constitutional and tumor deletions that define the Wilms' tumor locus on human chromosome 11 (band p13). The transcription unit corresponding to these clones spans approximately 50 kb and encodes an mRNA approximately 3 kb long. This mRNA is expressed in a limited range of cell types, predominantly in the kidney and a subset of hematopoietic cells. The polypeptide encoded by this locus has a number of features suggesting a potential role in transcriptional regulation. These include the presence of four zinc finger domains and a region rich in proline and glutamine. The amino acid sequence of the predicted polypeptide shows significant homology to two growth regulated mammalian polypeptides, EGR1 and EGR2. The genetic localization of this gene, its tissue-specific expression, and the function predicted from its sequence lead us to suggest that it represents the 11p13 Wilms' tumor gene.

Published
1990

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