162 results on '"Atchison K"'
Search Results
2. Alternative method of oral administration by peanut butter pellet formulation results in target engagement of BACE1 and attenuation of gavage-induced stress responses in mice
- Author
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Gonzales, C., Zaleska, M. M., Riddell, D. R., Atchison, K. P., Robshaw, A., Zhou, H., and Rizzo, Sukoff S.J.
- Published
- 2014
- Full Text
- View/download PDF
3. Indicators of oral health in diverse ethnic and age groups: Findings from the International Collaborative Study of Oral Health Outcomes (ICS-II) USA research locations
- Author
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Davidson, Pamela L., Andersen, Ronald M., Marcus, M., Atchison, K. A., Reifel, N., Nakazono, T., and Rana, H.
- Published
- 1996
- Full Text
- View/download PDF
4. ROTENONE-INDUCED AGGREGATION OF ALPHA-SYNUCLEIN IS REVERSED BY RAPAMYCIN: P.232
- Author
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Martone, R. L., Kubek, K., Atchison, K., Pong, K., Graziani, E., Jacobsen, J. S., Reinhart, P., and Pangalos, M.
- Published
- 2005
5. RATE OF CHANGE IN MANDIBULAR TRABECULAR PATTERN IS RELATED TO HIP FRACTURE RATE IN ELDERLY WOMEN
- Author
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White, S. C., Atchison, K., and Service, S.
- Published
- 2005
6. Oral Health Literacy, Preventive Behavior Measures, and Chronic Medical Conditions.
- Author
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Messadi, D. V., Macek, M. D., Markovic, D., and Atchison, K. A.
- Published
- 2018
- Full Text
- View/download PDF
7. (A106) Nursing Simulation in Disaster Management
- Author
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Moore, D., primary, Atchison, K., additional, and Boone, J., additional
- Published
- 2011
- Full Text
- View/download PDF
8. ChemInform Abstract: Synthesis and β-Lactamase Inhibitory Activity of 6-((1- Heteroarylthioethyl-1,2,3-triazol-4-yl)methylene)penam Sulfones.
- Author
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IM, C., primary, MAITI, S. N., additional, MICETICH, R. G., additional, DANESHTALAB, M., additional, ATCHISON, K., additional, PHILLIPS, O. A., additional, and KUNUGITA, C., additional
- Published
- 2010
- Full Text
- View/download PDF
9. ChemInform Abstract: Chemical Modification of Tazobactam - Synthesis of 2β-((4- Substituted)-1,2,3-triazol-1-yl)methyl Penicillanic Acid Sulfone Derivatives.
- Author
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SETTI, E. L., primary, FIAKPUI, C., additional, PHILLIPS, O. A., additional, CZAJKOWSKI, D. P., additional, ATCHISON, K., additional, MICETICH, R. G., additional, MAITI, S. N., additional, KUNUGITA, C., additional, and HYODO, A., additional
- Published
- 2010
- Full Text
- View/download PDF
10. P3‐296: BACE1 is not the rate‐limiting enzyme in Aβ production in the brains of APPswe transgenic mice: Pharmacological characterization of BACE1 using novel brain penetrant inhibitors.
- Author
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Riddell, D.R., primary, Atchison, K., additional, Yu, D., additional, Turner, J., additional, Wang, E., additional, Gonzales, C., additional, Warwick, H., additional, Kim, J., additional, Malamas, M., additional, Wagner, E., additional, Aschmies, S., additional, Albinson, K., additional, Erdel, J., additional, Gunawan, I., additional, Revilla‐Sanchez, R., additional, Takano, K., additional, Warren, N., additional, Fang, K., additional, Bard, J., additional, Hirst, W., additional, Pangalos, M., additional, Moss, S., additional, Haydon, P.G., additional, Robichaud, A., additional, and Reinhart, P., additional
- Published
- 2009
- Full Text
- View/download PDF
11. O2-04-02: Astrocytes preferentially degrade apoE4: Impact on Aβ levels and neuronal plasticity in apoE targeted replacement mice
- Author
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Riddell, David, primary, Zhou, H., additional, Atchison, K., additional, Warwick, H., additional, Atkinson, P., additional, Stewart, W., additional, Jefferson, J., additional, Xu, L., additional, Aschmies, S., additional, Kirksey, Y., additional, Hu, Y., additional, Wagner, E., additional, Parratt, A., additional, Xu, J., additional, Li, Z., additional, Zaleska, M.M., additional, Jacobsen, S.J., additional, Pangalos, M., additional, and Reinhart, P., additional
- Published
- 2009
- Full Text
- View/download PDF
12. NASA Lewis working on de-icing for small planes, copters
- Author
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Atchison, K
- Subjects
Aircraft Design, Testing And Performance - Published
- 1981
13. Nuclear system that burns its own wastes shows promise
- Author
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Atchison, K
- Subjects
Energy Production And Conversion - Abstract
A nuclear fission energy system, capable of eliminating a significant amount of its radioactive wastes by burning them, is described. A theoretical investigation of this system conducted by computer analysis, is based on use of gaseous fuel nuclear reactors. Gaseous core reactors using a uranium plasma fuel are studied along with development for space propulsion.
- Published
- 1975
14. Energy fact sheet
- Author
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Atchison, K
- Subjects
Energy Production And Conversion - Published
- 1980
15. Movers and shakers: Timelapse analysis of satellite cell migration
- Author
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Siegel, Ashley, primary, Atchison, K., additional, Davis, G.E., additional, and Cornelison, D.D.W., additional
- Published
- 2008
- Full Text
- View/download PDF
16. Sexual Activity and Satisfaction Among Very Old Adults: Results From a Community-Dwelling Medicare Population Survey
- Author
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Matthias, R. E., primary, Lubben, J. E., additional, Atchison, K. A., additional, and Schweitzer, S. O., additional
- Published
- 1997
- Full Text
- View/download PDF
17. Clinical and historical predictors of dental caries on radiographs.
- Author
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White, S C, primary, Atchison, K A, additional, Hewlett, E R, additional, and Flack, V F, additional
- Published
- 1995
- Full Text
- View/download PDF
18. An Empirical Test of the Validity of the Oral Health Status Index (OHSI) on a Minority Population.
- Author
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Spolsky, V. W., Marcus, M., Coulter, I. D., Der-Martirosian, C., and Atchison, K. A.
- Subjects
HEALTH status indicators ,DENTAL hygiene ,SOCIODEMOGRAPHIC factors ,HISPANIC Americans ,EPIDEMIOLOGY ,EMPIRICAL research - Abstract
Disease varies in different populations based on sociodemographic variables, and there is limited understanding of this interaction. The purpose of this methodological study was to determine the validity of the Oral Health Status Index, a disease-based index, on a Hispanic population by comparing it with the NIDCR epidemiological measures of disease, with the addition of demographic and behavioral variables. The epidemiologic data were collected according to the criteria defined by the NIDCR, including: a modified Decayed Missing Filled Surfaces Index, gingival inflammation, calculus, and destructive periodontal disease measures. The demographic and behavioral variables were gathered from 240 interviews with Hispanic adults in two community clinics. Bivariate analysis was used to determine relationships between the descriptive epidemiologic, demographic, and behavioral variables and the Oral Health Status Index (OHSI). There were statistically significant differences (p < 0.05) in mean OHSI scores among the demographic variables age, education, income, and place of birth; and the behavioral variables alcohol consumption, flossing, and acculturation. Multiple regression analysis with the OHSI as the dependent variable showed that the statistically significant (p < 0.001) epidemiologic predictors were: percentage of Decayed Teeth/Decayed, Filled Teeth; Number of Replaced Teeth/Missing Teeth; and millimeters of mesial attachment loss. These collectively explained 47.49% of the variance in the regression. The addition of demographic variables to the epidemiologic regression identified age (p < 0.05), gender (p < 0.01), and place of birth (p < 0.01) as significant predictors that explained an additional 4.12% of the variance, collectively bringing the total explained variance to 51.61%. The behavioral variables did not contribute significantly to predicting the OHSI regression score. The Oral Health Status Index in this study is validated by its correlation with both the epidemiologic measures and the demographic variables. This combination of variables separated the Hispanics into Mexicans and Central/South Americans. [ABSTRACT FROM AUTHOR]
- Published
- 2000
- Full Text
- View/download PDF
19. An association between dentate status and hearing acuity.
- Author
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Schell, Cathrina L., Diehl, Roberta L., Holmes, Alice E., Kubilis, Paul S., Loers, Wayne W., Atchison, Kathryn A., Dolan, Teresa A., Schell, C L, Diehl, R L, Holmes, A E, Kubilis, P S, Loers, W W, Atchison, K A, and Dolan, T A
- Published
- 1999
- Full Text
- View/download PDF
20. Oral health, health, and health-related quality of life.
- Author
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GIFT, HELEN C., ATCHISON, KATHRYN A., Gift, H C, and Atchison, K A
- Published
- 1995
21. Screening for depression among a well elderly population.
- Author
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Dorfman RA, Lubben JE, Mayer-Oakes A, Atchison K, Schweitzer SO, De Jong FJ, and Matthias RE
- Abstract
This article describes a geriatric wellness program in which social work practitioners played a major role. The focus of this article is twofold: to examine the use of a telephone screening test for depression among a well elderly population and to compare the results of that screening with the clinical judgment of social workers. Overall findings indicated that a telephone screening instrument incorporating the Rand Mental Health Inventory and the Center for Epidemiological Studies Depression Scale was an effcient tool for assessing a population with a higher rate of major depression. Furthermore, the social workers identified many previously undetected cases of major depression, and a majority of people referred for treatment completed those referrals. [ABSTRACT FROM AUTHOR]
- Published
- 1995
22. Comparisons between dentist ratings and self-ratings of dental appearance in an elderly population.
- Author
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Matthias, Ruth E., Atchison, Kathryn A., Schweitzer, Stuart O., Lubben, James E., Mayer-Oakes, Allison, Jong, Fred De, Matthias, R E, Atchison, K A, Schweitzer, S O, Lubben, J E, Mayer-Oakes, A, and De Jong, F
- Published
- 1993
- Full Text
- View/download PDF
23. PERCEIVED ORAL HEALTH IN A DIVERSE SAMPLE.
- Author
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ATCHISON, K. A. and GIFT, H. C.
- Subjects
SELF-evaluation ,HEALTH self-care ,ETHNICITY ,PARTIAL dentures ,ORAL hygiene ,OROFACIAL pain ,SOCIAL surveys ,AGING - Abstract
Measures of perceived oral health represent subjective, individual perspectives of one's health. One measure commonly used is the single-item perceived oral health rating: How would you rate your overall oral health? These analyses examine the associations among age, ethnicity, and perceived oral health within the context of a comprehensive battery of 21 predisposing, enabling, and need variables. The study compares the adult data from three United States research locations of the International Collaborative Study of Oral Health Outcomes (ICS-II). Only social survey data were used for this analysis. The multiple regression model explains over 30% of the variance in perceived oral health, with R squares ranging from 0.324 for Indian Health Service sites to 0.391 for San Antonio. The most important significant predictors include ethnic group, education, perceived general health status, being edentulous or not having a partial denture, having no oral pain, fewer oral symptoms, and having one or more dental visits. The predictors of positive perceived oral health for the diverse groups highlight interesting age and ethnic differences. The only universal predictor for the middle-aged adults was having fewer oral symptoms. For the older adults, being edentulous or not having a partial denture was the only universal predictor. The findings suggest that perceived oral health may be a useful outcome measure in dentistry because of its relation to predisposing sociodemographics and dental utilization. [ABSTRACT FROM AUTHOR]
- Published
- 1997
- Full Text
- View/download PDF
24. PREDISPOSING, ENABLING, AND NEED FOR DENTAL TREATMENT CHARACTERISTICS OF ICS-II USA ETHNICALLY DIVERSE GROUPS.
- Author
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ATCHISON, K. A., DAVIDSON, P. L., and NAKAZONO, T. T.
- Subjects
DENTAL care utilization ,HEALTH outcome assessment ,ORAL hygiene ,ETHNICITY ,AGING ,NATIVE Americans ,HISPANIC Americans - Abstract
Personal characteristics (predisposing, enabling, and need) are described for the population-based samples of adults interviewed in the International Collaborative Study of Oral Health Outcomes (ICS-II) USA research locations. Differences in sample characteristics are compared by ethnic group (African-American, Native American, Hispanic, and White) and age cohort (35-44 and 65-74 years old) by means of Bonferroni multiple-means tests and Student's t tests. Differences in the personal characteristics of these diverse comparison groups abound. Bivariate results indicated that White adults from both age cohorts had higher socioeconomic levels, more positive self-rated health status, and greater proportions of individuals with dental benefits. Lakota adults from both age cohorts reported lower self-rated health status and were most likely to report total tooth loss. Hispanic persons were significantly less likely to report a usual source of dental care or dental benefits. Need for dental treatment (oral pain and oral symptoms index) was generally higher among Native American and Hispanic groups. It is critical that the differences highlighted between and among these groups be studied if appropriate strategies for improving the oral health of USA adults are to be determined. [ABSTRACT FROM AUTHOR]
- Published
- 1997
- Full Text
- View/download PDF
25. Perceptions of the Natural Dentition in the Context of Multiple Variables.
- Author
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Gift, H. C., Atchison, K. A., and Drury, T. F.
- Subjects
DENTAL care utilization ,DENTAL therapeutics ,HEALTH behavior ,HUMAN behavior ,BEHAVIORAL medicine ,DENTISTRY - Abstract
Perceived oral health status has been shown to be associated with a variety of single clinical and self-reported indicators of oral health and oral health-related behaviors. A behavioral model is utilized which hypothesizes that perceived condition of natural teeth is predicted by multiple factors, including individual demographic and enabling characteristics, other health perceptions and orientations, actual levels of diseases and conditions, and self-defined need for treatment. The data are from the clinical examination and adult questionnaire of Phase 1 (1988-1991) of the Third National Health and Nutrition Examination Survey, which is based on a stratified multistage probability sample to produce nationally representative data for the civilian, non-institutionalized US population. Multivariate hierarchical regressions were used to assess perceived condition of natural teeth in two groups of dentate adults (those with a dental visit during the past 12 months, and those with a less recent dental visit). Self-defined treatment need made a significant, non-trivial contribution after other variables had been controlled. In both subpopulation models, the perception of general health and epidemiological indicators of oral health status were also significant factors. Socio-economic indicators did not contribute significantly in either regression. Understanding components of overall perceptions of oral health moves us closer to understanding oral health behaviors and oral-health-related quality of life. [ABSTRACT FROM AUTHOR]
- Published
- 1998
- Full Text
- View/download PDF
26. Relationships Between Clinician Variability and Radiographic Guidelines.
- Author
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Flack, V. F., Atchison, K. A., Hewlett, E. R., and White, S. C.
- Subjects
DENTAL radiography ,GUIDELINES ,STATISTICS ,DENTISTS ,CLINICAL indications ,PERIODONTAL disease ,TOOTH mobility ,DENTAL caries - Abstract
This study evaluated the replicability of clinical measurements under careful calibration of multiple dentists and how the replicability can relate to their use as selection criteria in guidelines for prescribing dental radiographs. For 48 consenting patients, three dentists clinically examined each patient and recorded the presence of all clinical findings using standardized selection criteria. The examinations were performed independently of each other, but with periodic conferences of the dentists to clarify general measurement criteria. The degree of agreement among the dentists is described by the interrater agreement kappa for several standard clinical indications such as rating of caries, periodontal disease, and tooth mobility. Almost perfect agreement was obtained for tooth status, restoration size, and restoration material. Moderate agreement resulted for measures of caries, defective restoration presence, and gingival recession presence. Only fair agreement was obtained for other periodontal disease measures. The relationship between extent of agreement and guidelines' results was examined for the FDA Guidelines. The differences among the dentists' clinical measurements resulted in considerable differences among the radiographs that were selected by the FDA Guidelines' criteria. Even so, the missed disease rates for 490 patients in a larger study of the FDA Guidelines' efficacy were very low and did not vary greatly among the three dentists. We conclude that guidelines' criteria can be quite robust to variation from dentists' clinical measurement differences, as seen from the FDA Guidelines applied under the idealized setting where the dentists are periodically recalibrated through group discussions of the clinical measurements' definitions and interpretations. [ABSTRACT FROM AUTHOR]
- Published
- 1996
- Full Text
- View/download PDF
27. Efficacy of the FDA Selection Criteria for Radiographic Assessment of the Periodontium.
- Author
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Atchison, K. A., White, S. C., Flack, V. F., Hewlett, E. R., and Kinder, S. A.
- Subjects
DENTAL radiography ,PERIODONTAL disease ,GUIDELINES ,PERIODONTITIS ,ALVEOLAR process ,DIAGNOSIS - Abstract
The diagnosis of periodontitis is generally made on the basis of a clinical examination supported by radiographic evidence of bone loss. Recent guidelines promulgated by the US Food and Drug Administration recommend that periapical radiographs be ordered on the basis of clinical signs and symptoms indicating the probable presence of disease. This study evaluated the effectiveness of the FDA Guidelines for ordering radiographs for new adult dental patients as related to assessment of the periodontal condition of the patient. We examined 490 patients and determined the periapicals needed to supplement the posterior bitewings based upon the patient's clinical findings. We measured the reduction in the number of radiographs ordered as well as the extent of missed alveolar and furcation bone loss resulting from the use of the selected set of radiographs compared with a complete set. Four hundred thirty-three subjects had at least one clinical sign of periodontitis present in their mouths, and 264 demonstrated radiographic evidence of alveolar bone loss. Of the 460 subjects on whom periodontal probing was conducted, two-thirds demonstrated periodontal probing depths in excess of 3 mm; almost half showed evidence of bleeding upon probing. Individuals with clinical signs of periodontitis had, on average, 10 periapicals ordered-more than twice the number as those with no sign of periodontitis. Of the 2,415 teeth with radiographic findings of proximal or furcal bone loss, 152 sites of bone loss (6%) were missed when the selected set of films plus the posterior bitewings was used. [ABSTRACT FROM AUTHOR]
- Published
- 1995
- Full Text
- View/download PDF
28. Radiographic Secondary Caries Prevalence in Teeth with Clinically Defective Restorations.
- Author
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HEWLETT, E. R., ATCHISON, K. A., WHITE, S. C., and FLACK, V.
- Subjects
DENTAL caries ,DENTAL fillings ,DISEASE relapse ,DENTAL radiography ,OPERATIVE dentistry complications ,DENTISTRY - Abstract
Decisions to replace existing restorations are often based on clinical findings of margin discrepancies and other restoration defects. Previous studies have suggested that such findings do not correlate well with the actual presence of secondary caries, and that treatment should be deferred until caries is clinically or radiographically evident. The purpose of this study was to assess the frequency with which clinically defective restorations are associated with radiographic secondary caries. As part of a study to assess the efficacy of guidelines for the ordering of dental radiographs, 6285 restored teeth in 490 subjects were examined clinically and radiographically by three calibrated investigators. Specific criteria were used to determine whether restorations were intact or defective. Of the total, 822 teeth (13%) were judged to have clinically defective restorations. Of these, 113 teeth (14%) had radiographic secondary caries. Of the 5463 teeth with intact restorations, 5% had radiographic secondary cares. We found that the likelihood of radiographic secondary caries was nearly three-fold higher for defective restorations than for intact restorations. The large percentage (86%) of defective restorations with no radiographic secondary caries suggests, however, that replacement of all defective restorations due to risk of secondary caries may constitute overtreatment. The use of defective restoration status and presence of radiographic secondary caries as a combined criterion for replacement may potentially reduce such overtreatment. The prevalence of secondary caries under defective restorations should be determined clinically so that the usefulness of combining the criteria of defective restoration with those of radiographic secondary caries can be evaluated. [ABSTRACT FROM AUTHOR]
- Published
- 1993
- Full Text
- View/download PDF
29. Astrocytes preferentially degrade apoE4: Impact on Aβ levels and neuronal plasticity in apoE targeted replacement mice
- Author
-
Riddell, David, Zhou, H., Atchison, K., Warwick, H., Atkinson, P., Stewart, W., Jefferson, J., Xu, L., Aschmies, S., Kirksey, Y., Hu, Y., Wagner, E., Parratt, A., Xu, J., Li, Z., Zaleska, M.M., Jacobsen, S.J., Pangalos, M., and Reinhart, P.
- Published
- 2009
- Full Text
- View/download PDF
30. BACE1 is not the rate-limiting enzyme in Aβ production in the brains of APPswe transgenic mice: Pharmacological characterization of BACE1 using novel brain penetrant inhibitors.
- Author
-
Riddell, D.R., Atchison, K., Yu, D., Turner, J., Wang, E., Gonzales, C., Warwick, H., Kim, J., Malamas, M., Wagner, E., Aschmies, S., Albinson, K., Erdel, J., Gunawan, I., Revilla-Sanchez, R., Takano, K., Warren, N., Fang, K., Bard, J., Hirst, W., Pangalos, M., Moss, S., Haydon, P.G., Robichaud, A., and Reinhart, P.
- Published
- 2009
- Full Text
- View/download PDF
31. Using Information Technology and Community-based Research to Improve the Dental Health-care System.
- Author
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Atchison, K. A.
- Subjects
HEALTH care reform ,MEDICAL care ,DENTAL care ,INFORMATION technology ,DENTAL schools - Abstract
It is commonly acknowledged that the United States' health-care system produces some of the finest care in the world for some people but fails to meet the needs of others. The Institute of Medicine (IOM) issued six aims for a redesigned health-care system, that it be: safe, effective, patient-centered, timely, efficient, and equitable. The purpose of this paper is to use an ongoing community-based study to illustrate current problems in the provision of oral health services that could be addressed through information technology. Appropriate use of information technology can assist dental schools and clinics in community-based clinical outcomes research needed to assemble the evidence base for improving oral health care. This conference serves as an important steppingstone to establish a means for information technology to improve the community's oral health. [ABSTRACT FROM AUTHOR]
- Published
- 2003
- Full Text
- View/download PDF
32. Bisindolylmaleimides Linked to DNA Minor Groove Binding Lexitropsins: Synthesis, Inhibitory Activity against Topoisomerase I, and Biological Evaluation
- Author
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Xie, G., Gupta, R., Atchison, K., and Lown, J. W.
- Abstract
The synthesis, characterization, inhibitory activity against topoisomerase I, and biological evaluation of a series of oligopeptide-substituted bisindolylmaleimides
7−12 are described. Compounds7−9 , which contain a basic C-terminus function such as (dimethylamino)propyl and bind to DNA with C50 values of 200, 160, and 135 μM, respectively, exhibited inhibition of topoisomerase I in a concentration dependent manner. Also, the relative order of observed topoisomerase I inhibition is9 >8 >7 at ≤100 μM concentration, corresponding to the increase of the number of pyrrole units in the oligopeptide moiety. Compounds10−12 , which contain an electrostatically neutral moiety, such as methyl ester, did not bind to DNA templates nor inhibit topoisomerase I. However, the cytotoxicity activities of these compounds were 1.5 times greater than those of compounds7−9 .- Published
- 1996
33. ChemInform Abstract: Chemical Modification of Tazobactam - Synthesis of 2β-((4- Substituted)-1,2,3-triazol-1-yl)methyl Penicillanic Acid Sulfone Derivatives.
- Author
-
SETTI, E. L., FIAKPUI, C., PHILLIPS, O. A., CZAJKOWSKI, D. P., ATCHISON, K., MICETICH, R. G., MAITI, S. N., KUNUGITA, C., and HYODO, A.
- Published
- 1996
- Full Text
- View/download PDF
34. ChemInform Abstract: Synthesis and β-Lactamase Inhibitory Activity of 6-((1- Heteroarylthioethyl-1,2,3-triazol-4-yl)methylene)penam Sulfones.
- Author
-
IM, C., MAITI, S. N., MICETICH, R. G., DANESHTALAB, M., ATCHISON, K., PHILLIPS, O. A., and KUNUGITA, C.
- Published
- 1995
- Full Text
- View/download PDF
35. Synthesis of ring-A-opened isopicropodophyllins as potential DNA topoisomerase II inhibitors
- Author
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Kamal, A., Daneshtalab, M., Atchison, K., and Micetich, R. G.
- Published
- 1994
- Full Text
- View/download PDF
36. "Are my blood products coming?": Implementation of a novel blood product tracker in the electronic health record system.
- Author
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Chai T, Hartzell C, Winstead R, Krokosky K, Atchison K, Mueller A, Hall E, Wanderer JP, and Andrews J
- Subjects
- Humans, Electronic Health Records, Blood Banks, Blood Transfusion
- Abstract
Background: Blood transfusions are the most common procedure performed in American hospitals. The steps required for blood product delivery are often misunderstood by providers, leading to numerous phone calls to the blood bank requesting order status. Distracting calls can lengthen turnaround time, especially during blood product or staff shortages. We sought a tool to address these questions and reduce distraction. This study highlights a novel blood tracker tool implemented in the electronic health record (EHR) that allows providers to see their blood order's status., Study Design and Methods: With a multidisciplinary team of healthcare professionals, we constructed a user-friendly blood tracker highly visible in our EHR. It shows the status of a blood product in real time from "order printed" to "preparing" to "on its way." We surveyed blood bank technologists to determine if call volume and distraction changed., Results: We counted the number of views per month as a surrogate of usage. The blood tracker was viewed 109,626 times per month on average from January through December 2023. The fraction of technologists who received 21 or more calls per shift decreased by 47%., Discussion: We successfully constructed and implemented a novel blood tracker into our EHR that relays the status of a blood product. It is a highly viewed piece of information in our EHR and decreases blood bank call volume as reported by blood bank technologists. Its success demonstrates that closed-loop communication between the lab and providers regarding blood products is beneficial within our organization and potentially others., (© 2024 The Author(s). Transfusion published by Wiley Periodicals LLC on behalf of AABB.)
- Published
- 2025
- Full Text
- View/download PDF
37. Treatments for Depression for Older Adults Living in Long-Term Care: A Systematic Review and Network Meta-Analysis.
- Author
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Atchison K, Hoang PM, Merrikh D, Chang C, Watt JA, Hofmeister M, and Goodarzi Z
- Abstract
Objective: To assess the comparative efficacy of interventions on depressive symptoms and disorders in older adults living in long-term care (LTC)., Design: Systematic review and network meta-analysis., Setting and Participants: Older adults living in LTC or equivalent settings., Methods: We searched 6 electronic databases and gray literature sources to identify randomized controlled trials describing pharmacologic or nonpharmacologic interventions. Studies had to measure depression as an outcome in persons living in LTC. Study inclusion and study quality were assessed in duplicate. Population characteristics, descriptions of intervention and control treatments, and end-point depression scores for each treatment were extracted from included studies. A network meta-analysis using the standardized mean difference (SMD) of depression scores was completed using a random effects model., Results: A total of 182 studies were included in the review. The network meta-analysis was completed with 147 studies and included 31 treatment conditions. Compared with usual care, horticulture therapy (SMD, -6.85; 95% Credibility Interval, -8.49 to -5.22) and cognitive behavioral therapy (SMD, -1.98; 95% Credibility Interval, -2.91 to -1.05) were the most efficacious treatments. Animal therapy, group reminiscence therapy, multicomponent nonpharmacologic treatments, exercise, and socialization interventions also significantly improved depressive symptoms compared with usual care., Conclusions and Implications: Many nonpharmacologic treatments for depression in residents of LTC have been studied and are found to be efficacious. The low-risk and cost-effective nature of many of the nonpharmacologic interventions makes them ideal for use in LTC. More studies of pharmacologic treatments are needed to inform prescribing for depression in the LTC population. The range of treatments available for depression may help clinicians select therapies individualized to resident needs., Competing Interests: Disclosure The authors declare no conflicts of interest., (Copyright © 2024. Published by Elsevier Inc.)
- Published
- 2024
- Full Text
- View/download PDF
38. Depression detection in dementia: A diagnostic accuracy systematic review and meta analysis update.
- Author
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Atchison K, Nazir A, Wu P, Seitz D, Watt JA, and Goodarzi Z
- Abstract
Background: Depression is common in persons with dementia and is often under-detected and under-treated. It is critical to understand which available tools accurately detect depression in the context of dementia., Methods: We updated our systematic review completed in 2015. The search strategy of our original review was replicated in Medline, Embase, and PsycINFO. Studies describing the use of a tool to identify depression in persons with dementia, compared to a criterion standard, and reporting diagnostic accuracy outcomes were included in the review update. Pooled prevalence estimates of major depression and pooled estimates of diagnostic accuracy outcomes (i.e., sensitivity [SN], specificity [SP]) for tools were calculated., Results: Three studies were included of the 8980 returned from the database search and were added to the prior 20 articles from the 2015 review. The Cornell Scale for Depression in Dementia (CSDD), Geriatric Depression Scale (GDS)-15 item, Neuropsychiatric Inventory-Depression items (NPI-D), and Depression in Old Age Scale (DIA-S) were evaluated in the three studies. Two new studies were added to the existing pooled prevalence estimate of major depression (29%, 95% confidence interval [CI] = 21.6%-36.5%, n = 17) and pooled diagnostic accuracy estimate for the CSDD at the best cut-off (SN = 0.83, 95% CI = 0.74-0.90; SP = 0.81, 95% CI = 0.69-0.89). New pooled diagnostic accuracy estimates were completed for the CSDD (cut-off ≥12) (SN = 0.61, 95% CI = 0.42-0.77; SP = 0.83, 95% CI = 0.76-0.88), GDS-15 (best cut-off) (SN = 0.65, 95% CI = 0.40-0.83; SP = 0.72, 95% CI = 0.55-0.85), and Montgomery Asberg Depression Rating Scale (MADRS) (best cut-off) (SN = 0.77, 95% CI = 0.67-0.85; SP = 0.68, 95% CI = 0.60-0.75)., Conclusions: The CSDD continues to have the most evidence for depression case finding in persons living with dementia. The CSDD and Hamilton Depression Rating Scale have the highest sensitivities and may be recommended for use over other common tools like the GDS-15 and MADRS. Newly identified tools like the NPI-D and DIA-S require further study before they can be recommended for use in practice., Competing Interests: The authors declare no conflicts of interest., (© 2024 The Author(s). Health Science Reports published by Wiley Periodicals LLC.)
- Published
- 2024
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39. Insomnia and unhealthy alcohol use in a National Sample of Women Veterans 50 years and older enrolled in the Veterans Health Administration.
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Tighe CA, Quinn DA, Boudreaux-Kelly M, Atchison K, and Bachrach RL
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- Humans, Female, Middle Aged, United States epidemiology, Aged, Alcoholism epidemiology, Veterans Health, Sleep Initiation and Maintenance Disorders epidemiology, Veterans statistics & numerical data, United States Department of Veterans Affairs
- Abstract
In this study, we examined rates of insomnia and co-occurring unhealthy alcohol use in a national sample of women Veterans age 50 years and older. We further explored associations between sociodemographic measures, insomnia-related clinical characteristics, and unhealthy alcohol use, and analyzed whether women with insomnia were more likely to report unhealthy alcohol use. Study aims were evaluated using national Veterans Health Administration (VA) electronic health records data from VA's Corporate Data Warehouse. Data were extracted for women Veterans ≥50 years old with ≥1 VA primary care visit in each study year (2018: 3/11/18-3/10/19; 2020: 3/11/20-3/10/21; 2022: 3/11/22-3/10/23). Cases of insomnia were identified via diagnostic codes and prescription medications for insomnia. Unhealthy alcohol use was identified via Alcohol Use Disorders Identification Test-Consumption screening scores indicating unhealthy alcohol use. Annual sample sizes ranged from 240,420-302,047. Over the study timeframe, insomnia rates (diagnosis or medication) among women ≥50 years old ranged from 18.11-19.29%; co-occurring insomnia and unhealthy alcohol use rates ranged from 2.02-2.52%. Insomnia and unhealthy alcohol use rates were highest among women aged 50-59 years old. Depression and physical health comorbidities were consistently associated with insomnia; associations by race and ethnicity were less consistent. Compared to women without insomnia, women Veterans with either concurrent or unremitting insomnia were more likely to endorse unhealthy alcohol use. Findings signal a potential need for assessment and preventative efforts aimed at addressing insomnia and unhealthy alcohol use among women Veterans.
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- 2024
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40. Screening for Elder Abuse in the Veterans Health Administration: Varied Approaches Across a National Health System.
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Makaroun LK, Halaszynski JJ, Smith KA, Drake R, Amelio-Hering V, Atchison K, Dichter ME, Rosland AM, Thorpe CT, and Rosen T
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- Humans, United States epidemiology, Aged, Surveys and Questionnaires, Male, Female, Veterans Health, Elder Abuse diagnosis, Elder Abuse statistics & numerical data, United States Department of Veterans Affairs, Mass Screening methods, Mass Screening standards
- Abstract
Background: Elder abuse (EA) is common and has devastating health consequences yet is rarely detected by healthcare professionals. While EA screening tools exist, little is known about if and how these tools are implemented in real-world clinical settings. The Veterans Health Administration (VHA) has experience screening for, and resources to respond to, other forms of interpersonal violence and may provide valuable insights into approaches for EA screening., Objective: Describe EA screening practices across a national integrated healthcare system serving a large population of older adults at risk for EA., Design: Survey of all 139 VHA medical centers from January to August 2021., Participants: Surveys were completed by the Social Work Chief, or delegate, at each site., Main Measures: The survey assessed the presence and characteristics of EA-specific screening practices as well as general abuse/neglect screening conducted with patients of all ages, including older adults. Follow-up emails were sent to sites that reported screening requesting additional details not included in the initial survey., Key Results: Overall, 130 sites (94%) responded. Among respondents, 5 (4%) reported screening older adults for EA using a previously published tool, while 6 (5%) reported screening for EA with an unstudied or locally developed tool. Forty-eight percent reported screening patients of all ages for general abuse/neglect using unstudied questions/tools, and 44% reported no EA screening at their site. Characteristics of screening programs (e.g., frequency, clinical setting, provider type) varied widely between sites, as did respondents' understanding of the definition of screening., Conclusions: High variability in screening practices for abuse/neglect and lack of EA-specific screening in a system that has successfully deployed other standardized screening approaches present an important opportunity to standardize and improve EA detection practices. Lessons learned in VHA could help advance the evidence base for EA screening more broadly to increase overall detection rates for EA nationally., (© 2024. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)
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- 2024
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41. Detection of anxiety symptoms and disorders in older adults: a diagnostic accuracy systematic review.
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Atchison K, Wu P, Samii L, Walsh M, Ismail Z, Iaboni A, and Goodarzi Z
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- Humans, Aged, Female, Male, Independent Living, Psychiatric Status Rating Scales standards, Reproducibility of Results, Aged, 80 and over, Age Factors, Predictive Value of Tests, Anxiety diagnosis, Anxiety psychology, Anxiety epidemiology, Anxiety Disorders diagnosis, Anxiety Disorders psychology, Anxiety Disorders epidemiology, Geriatric Assessment methods
- Abstract
Background: Anxiety symptoms and disorders are common in older adults and often go undetected. A systematic review was completed to identify tools that can be used to detect anxiety symptoms and disorders in community-dwelling older adults., Methods: MEDLINE, Embase and PsycINFO were searched using the search concepts anxiety, older adults and diagnostic accuracy in March 2023. Included articles assessed anxiety in community-dwelling older adults using an index anxiety tool and a gold standard form of anxiety assessment and reported resulting diagnostic accuracy outcomes. Estimates of pooled diagnostic accuracy outcomes were completed., Results: Twenty-three anxiety tools were identified from the 32 included articles. Pooled diagnostic accuracy outcomes were estimated for the Geriatric Anxiety Inventory (GAI)-20 [n = 3, sensitivity = 0.89, 95% confidence interval (CI) = 0.70-0.97, specificity = 0.80, 95% CI = 0.67-0.89] to detect generalized anxiety disorder (GAD) and for the GAI-20 (n = 3, cut off ≥ 9, sensitivity = 0.74, 95% CI = 0.62-0.83, specificity = 0.96, 95% CI = 0.74-1.00), Beck Anxiety Inventory (n = 3, sensitivity = 0.70, 95% CI = 0.58-0.79, specificity = 0.60, 95% CI = 0.51-0.68) and Hospital Anxiety and Depression Scale (HADS-A) (n = 3, sensitivity = 0.78, 95% CI = 0.60-0.89, specificity = 0.76, 95% CI = 0.60-0.87) to detect anxiety disorders in clinical samples., Conclusion: The GAI-20 was the most studied tool and had adequate sensitivity while maintaining acceptable specificity when identifying GAD and anxiety disorders. The GAI-20, GAI-Short Form and HADS-A tools are supported for use in detecting anxiety in community-dwelling older adults. Brief, self-rated and easy-to-use tools may be the best options for anxiety detection in community-dwelling older adults given resource limitations. Clinicians may consider factors including patient comorbidities and anxiety prevalence when selecting a tool and cut off., (© The Author(s) 2024. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
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- 2024
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42. Psychosis detection in dementia: a systematic review of diagnostic test accuracy studies.
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Atchison K, Wu P, Watt JA, Seitz D, Ismail Z, and Goodarzi Z
- Abstract
Introduction: Symptoms of psychosis, characterized by delusions and hallucinations, are commonly experienced by persons living with dementia. A systematic review was completed to identify tools to evaluate symptoms of psychosis compared to a reference standard in persons with dementia. Articles reporting correlation values between psychosis tools were also identified., Methods: The search concepts psychosis, dementia, and diagnostic accuracy were used to search MEDLINE, PsycINFO, and Embase. Included articles meeting the primary objective described a tool to assess symptoms of psychosis, delusions, or hallucinations in persons with dementia, a reference standard form of diagnostic assessment for psychosis, and diagnostic accuracy outcomes for the psychosis tool. Secondary objective articles reported correlation values between two or more psychosis tools in persons with dementia., Results: One study met the primary objective and described the sensitivity and specificity of the Neuropsychiatric Inventory (NPI) and Columbia University Scale for Psychopathology in Alzheimer's Disease (CUSPAD) in identifying symptoms of psychosis, hallucinations, and delusions. The sensitivity of the NPI and CUSPAD in identifying symptoms of psychosis was 83 and 90%, respectively. Nine studies meeting the secondary objective described eleven unique tools and examined the degree to which tools used to assess psychotic symptoms in persons with dementia were related., Discussion: The NPI and CUSPAD were identified in a single study as psychosis tools that have been evaluated against a reference standard of psychosis assessment in persons with dementia. Various tools to assess the burden of psychotic symptoms in persons with dementia exist, but the diagnostic accuracy of existing tools remains understudied. Further research on the comparative utility and diagnostic accuracy is required for all psychosis tools used with persons with dementia., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision., (Copyright © 2024 Atchison, Wu, Watt, Seitz, Ismail and Goodarzi.)
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- 2024
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43. Understanding the Barriers to and Facilitators of Anxiety Management in Residents of Long-Term Care.
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Atchison K, Toohey AM, Ismail Z, and Goodarzi Z
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- Humans, Aged, Qualitative Research, Delivery of Health Care, Anxiety therapy, Long-Term Care, Cognitive Dysfunction
- Abstract
Older adults, 65 years of age and older, living in long-term care (LTC) commonly experience anxiety. This study aimed to understand care providers' perspectives on the barriers to and facilitators of managing anxiety in residents of LTC. Ten semi-structured interviews with care providers in LTC were completed. Framework analysis methods were used to code, thematically analyze, designate codes as barriers or facilitators, and map the codes to the Theoretical Domains Framework. Themes were categorized as acting at the resident, provider, or system level, and were labelled as either barriers to or facilitators of anxiety care. Key barriers to anxiety care at each level were resident cognitive impairment or co-morbidities; lack of staff education, staff treatment uptake and implementation; as well as the care delivery environment and access to resources. There is a need to prioritize measurement-based care for anxiety, have increased access to non-pharmacological treatments, and have a care delivery environment that supports anxiety management to improve the care for anxiety that is delivered to residents.
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- 2024
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44. Sleep and Alcohol Use Among Veterans Living With Long COVID.
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Bachrach RL, Tighe CA, Beyer N, Hruska K, Phares A, Atchison K, Baniak L, Haas G, and Bramoweth AD
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- United States epidemiology, Humans, Post-Acute COVID-19 Syndrome, United States Department of Veterans Affairs, Ethanol, Qualitative Research, Veterans, COVID-19 epidemiology, Sleep Wake Disorders epidemiology
- Abstract
Objectives: Study objectives were to: (1) better understand sleep experiences and unhealthy alcohol use among Veterans with long COVID and (2) explore providers' perceptions of barriers and facilitators to delivering evidence-based care for sleep problems and unhealthy alcohol use in patients with long COVID., Methods: VA electronic health records were used to conduct chart reviews (n = 57) of patients evaluated in a VA COVID-19 Recovery Clinic during 1 calendar year; semi-structured interviews were completed with Veterans (n = 5) and clinicians (n = 7) recruited from the clinic. Veteran participants also completed quantitative, self-report measures assessing sleep- and alcohol-related experiences and behaviors., Results: Data from chart reviews and interviews suggested that Veterans with long COVID often had pre-existing sleep problems that were exacerbated during long COVID. Patients and providers agreed that sleep interventions would be beneficial and acceptable in the COVID-19 Recovery clinic. Conversely, few Veterans with long COVID had a pre-existing alcohol use disorder (AUD) diagnosis; alcohol use occurred less frequently and was less often discussed between patients and providers. Providers had mixed viewpoints on delivering alcohol-related care in the clinic; some were highly amenable, others were unsure whether patients would be receptive., Conclusions: This study is among the first to take a mixed-method approach to understanding experiences of sleep-wake behaviors and unhealthy alcohol use in Veterans with long COVID. Characterizing sleep and alcohol-related experiences, examining associations with functioning, and exploring perspectives on treatment approaches is critical to support efforts to refine, personalize, and optimize evidence-based sleep and alcohol care for Veterans living with long COVID., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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- 2024
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45. Geroscience: Aging and Oral Health Research.
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Weintraub JA, Kaeberlein M, Perissinotto C, Atchison KA, Chen X, D'Souza RN, Feine JS, Ghezzi EM, Kirkwood KL, Ryder M, Slashcheva LD, Touger-Decker R, Wu B, and Kapila Y
- Subjects
- Aged, Humans, Aging, Geroscience, Oral Health, United States, Biological Products, Mouth Diseases
- Abstract
Research in aging has significantly advanced; scientists are now able to identify interventions that slow the biologic aging processes (i.e., the "hallmarks of aging"), thus delaying the onset and progression of multiple diseases, including oral conditions. Presentations given during the 3-part session "Geroscience: Aging and Oral Health Research," held during the 2023 American Association for Dental, Oral, and Craniofacial Research meeting, are summarized in this publication. Speakers' topics spanned the translational research spectrum. Session 1 provided an overview of the geroscience and health span (disease-free and functional health throughout life) concepts. The common molecular mechanisms between oral cancer and aging were discussed, and research was presented that showed periodontal microflora as a potential factor in Alzheimer's disease progression. Session 2 focused on behavioral and social science aspects of aging and their oral health significance. The keynote provided evidence that loneliness and isolation can have major health effects. These social conditions, along with poor oral health, tooth loss, and cognitive decline, could potentially affect healthy eating ability and systemic health in older adults. Research could help elucidate the directions and pathways connecting these seemingly disparate conditions. Session 3 focused on the delivery of oral care in different settings and the many barriers to access care faced by older adults. Research is needed to identify and implement effective technology and strategies to improve access to dental care, including new delivery and financing mechanisms, workforce models, interprofessional provider education and practice, and use of big data from medical-dental integration of electronic health records. Research to improve the "oral health span," reduce oral health disparities, and increase health equity must be tackled at all levels from biologic pathways to social determinants of health and health policies., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: M. Kaeberlein is Chief Science Officer at Optispan, a company focused on developing solutions for science-based preventative and longevity medicine. Optispan is not currently engaged in any oral health or rapamycin-related projects. C. Perissinotto is a research consultant to Papa Health. As part of this presentation, M. Ryder discussed research and results from several FDA clinical trials that were developed, supervised, and supported by the company formerly known as Cortexyme Inc/Quince Therapeutics (now Lighthouse Phama). M. Ryder was a former member of the Clinical Advisory Board of Cortexyme Inc., where he assisted in the design of these studies and preparation of manuscripts, holds stock, and received consulting fees. L.D. Slashcheva is an employee of Apple Tree Dental but has no financial conflicts of interest in representing the organization.
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- 2023
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46. Difficulty with Oral Health Complications in Adolescents with Developmental Disability and Obesity.
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Bhoopathi V, Wells C, Ramos-Gomez F, and Atchison KA
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- Child, Humans, Adolescent, Developmental Disabilities epidemiology, Developmental Disabilities complications, Cross-Sectional Studies, Toothache complications, Obesity complications, Obesity epidemiology, Oral Health, Dental Caries epidemiology, Dental Caries complications
- Abstract
Introduction: Developmental disabilities (DDs), obesity, and dental caries are highly prevalent health conditions among adolescents. Evidence indicates that a significant proportion of adolescents with DDs are obese, and those with obesity and dental caries share common risk factors., Objective: In this first-ever US-based cross-sectional national study, we assessed the likelihood of adolescents with DDs and obesity experiencing chronic difficulty with decayed teeth, toothaches, bleeding gums, and eating and swallowing due to a health condition among adolescents with DDs and obesity compared to adolescents with no DDs or obesity., Methods: For this secondary data analysis study, we used data of 68,942 adolescents aged 10 to 17 y from the 2016 through 2019 National Survey of Children's Health. Weighted descriptive and bivariate analyses were conducted. Four multiple logistic regression models predicting chronic difficulty in the past 12 mo with decayed teeth, toothaches, bleeding gums, and eating and swallowing due to a health condition were conducted, controlling for other variables., Results: The adjusted odds ratio (aOR) of experiencing chronic difficulty in the past 12 mo for adolescents with no DDs or obesity was significantly lower for decayed teeth (aOR, 0.64; 95% confidence interval [CI], 0.51-0.80; P < 0.0001), toothaches (aOR, 0.43; 95% CI, 0.30-0.60; P < 0.0001), bleeding gums (aOR, 0.48; 95% CI, 0.33-0.70; P < 0.0001), and eating or swallowing due to a health condition (aOR, 0.34; 95% CI, 0.20-0.57; P < 0.0001) compared to adolescents with both DDs and obesity., Conclusions: Results from this study indicate that DD adolescents with obesity have more/greater impending oral health needs than adolescents with no DDs or obesity., Knowledge Transfer Statement: Results of this study highlight the high oral health needs and the chronic difficulty adolescents with developmental disabilities and obesity experience compared to adolescents without developmental disabilities and obesity. Targeted oral health policies and interventions that will promote oral health among this high-risk group are recommended.
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- 2023
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47. Association between oral health knowledge, perceived oral health related quality of life, perceived oral health status and emergency department and/or urgent care visit: Results from the multi-site oral health literacy study.
- Author
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Adunola F, Macek MD, Atchison K, and Akinkugbe A
- Subjects
- Adult, Humans, Quality of Life, Emergency Service, Hospital, Ambulatory Care, Oral Health, Health Literacy
- Abstract
Objectives: To assess the link between oral health knowledge (OHK), self-perceived oral health, and emergency room (ER)/urgent care utilization for a dental problem., Methods: Data were analyzed from a convenience sample of 790 adult participants who presented to two US dental schools and completed an interviewer-administered survey. Key independent variables were OHK assessed with the Comprehensive Measure of Oral Health Knowledge (CMOHK) instrument, self-perceived oral health status and quality of life determined using the General Oral Health Assessment Index (GOHAI) scores. The dependent variable was ER and/or urgent care utilization for a dental problem. Select sociodemographic variables such as age and gender were adjusted for in logistic regression models using SAS., Results: 15.7% of the participants had ever visited an ER and/or urgent care for a dental problem. CMOHK scores were not significantly associated with visits to the ER and/or urgent care. In adjusted analysis, participants with unfavorable GOHAI scores were about three times as likely to have had an ER and/or urgent care visit (OR = 2.60, 95% CI: 1.66-4.09). Similarly, participants who were unsatisfied with their oral health were about twice as likely to have had an ER and/or urgent care visit (OR = 1.91, 95% CI: 1.21-3.00) as compared to those satisfied with their oral health status., Conclusion: Individuals unsatisfied with their oral health and those with unfavorable perceived oral health related quality of life could benefit from a greater awareness of dental service availability and extended hours including weekend hours at public dental clinics., (© 2023 American Association of Public Health Dentistry.)
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- 2023
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48. Detecting Anxiety in Long-Term Care Residents: A Systematic Review.
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Atchison K, Shafiq S, Ewert D, Leung AA, and Goodarzi Z
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- Humans, Aged, Anxiety Disorders diagnosis, Long-Term Care, Anxiety diagnosis
- Abstract
Anxiety is common in long-term care (LTC), but it is unclear which anxiety detection tools are accurate when compared to a reference standard for residents of LTC. Four databases and grey literature sources were searched using the search concepts "anxiety" and "LTC". Included studies evaluated the diagnostic accuracy of an anxiety detection tool compared to a reference standard in LTC residents. Diagnostic accuracy measures were extracted. Four articles out of 4,620 met the inclusion criteria. Despite limited evidence and poorly reported study procedures and characteristics, the Geriatric Anxiety Inventory (sensitivity: 90.0%, specificity: 86.2%) and the Hospital Anxiety and Depression Scale-Anxiety (sensitivity: 90.0%, specificity: 80.6%) had the best performance when detecting generalized anxiety disorder. We identified four anxiety detection tools appropriate for use in LTC; a critical first step to diagnosing and managing anxiety in residents of LTC. Non-generalized anxiety disorders and tool feasibility must be further evaluated.
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- 2023
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49. Quality of Life in Patients With Recurrent and Second Primary Head and Neck Cancer.
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Ramprasad VH, Li J, Atchison K, Zandberg DP, Clump DA, Johnson JT, and Nilsen ML
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- Humans, Retrospective Studies, Squamous Cell Carcinoma of Head and Neck therapy, Neoplasm Recurrence, Local therapy, Surveys and Questionnaires, Quality of Life, Head and Neck Neoplasms therapy
- Abstract
Objective: In the setting of similar outcomes, quality of life (QOL) measures can be utilized to compare treatment modalities in head and neck squamous cell carcinoma (HNSCC). We evaluate QOL and symptoms in patients treated for primary, second primary, and recurrent HNSCC., Study Design: Retrospective cohort study., Setting: Head and neck cancer survivorship clinic., Methods: We identified patients seen between 2016 and 2019. QOL and symptoms were assessed with the University of Washington Quality of Life (UW-QOL) questionnaire, 10-item Eating Assessment Tool, 8-item Patient Health Questionnaire, 7-item Generalized Anxiety Disorder, and Neck Disability Index. Regression analysis was utilized to explore associations and compare QOL outcomes., Results: Our cohort comprised 662 patients: 546 with primary HNSCC, 34 with second primary HNSCC, and 82 with recurrent HNSCC. Multimodality therapy was associated with lower UW-QOL Physical Subscale (UW-QOL-PS) vs single modality: chemoradiation therapy (-12.17 [95% CI, -16.57 to -7.78]) and surgery + postadjuvant treatment (-12.11 [-16.06 to -8.16]). Multimodality therapy was also associated with lower UW-QOL Social-Emotional Subscale (UW-QOL-SS): chemoradiation therapy (-6.70 [-11.41 to -1.99]) and surgery + postadjuvant treatment (-7.41 [-11.63 to -3.19]). Recurrence (-14.42 [-18.80 to -10.04]) and second primary (-11.15 [-17.71 to -4.59]) demonstrated lower UW-QOL-PS vs primary. Radiation for recurrence or second primary had worse UW-QOL-PS (-10.43 [-19.27 to -1.59]) and UW-QOL-SS (-10.58 [-18.76 to -1.54]) and higher Eating Assessment Tool (6.08 [1.39-10.77]) than surgery alone. Surgery + postadjuvant treatment showed worse UW-QOL-PS (-12.65 [-23.76 to -1.54]) and UW-QOL-SS (-12.20 [-22.38 to -2.03])., Conclusion: Multimodality therapy, particularly with recurrent and second primary HNSCC, is more likely to contribute to diminished QOL and symptoms. This important consideration should play a role in framing informed discussions with patients regarding treatment., (© 2023 American Academy of Otolaryngology-Head and Neck Surgery Foundation.)
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- 2023
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50. Health Literacy and Adherence to Clinical Recommendations in Head and Neck Cancer.
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Harley RJ, Atchison K, Li J, Losego K, Wasserman-Wincko T, Johnson JT, and Nilsen ML
- Subjects
- Humans, Retrospective Studies, Cohort Studies, Survivors, Health Literacy, Head and Neck Neoplasms therapy
- Abstract
Background: After definitive cancer treatment, survivors of head and neck cancer (HNC) are commonly recommended to participate in therapies aimed at reducing the burden of treatment-related side effects., Objective: In this study, we evaluated whether adherence to referral to physical therapy (PT) and speech-language pathology therapy (SLPT) is related to patient health literacy (HL)., Methods: This is a retrospective cohort analysis of patients attending a multidisciplinary HNC survivorship clinic between 2017 and 2019. HL was measured using the Brief Health Literacy Screen, with scores below 10 indicating inadequate HL. Chi-square and logistic regression were used to evaluate the association between HL and adherence to PT or SLPT referral., Key Results: From the overall cohort ( N = 454), 80 patients (18%) had inadequate HL. Compared to those with adequate HL, patients with inadequate HL were significantly less likely to complete initial PT evaluation (74% vs. 58%, p = .034) but were not significantly less likely to complete initial SLPT evaluation (70% vs. 61%, p = .37). After adjusting for age, primary tumor site, and treatment stage, we found that patients with inadequate HL were half as likely to follow up for initial PT evaluation (odds ratio 0.45, p = .032)., Conclusion: Overall, inadequate HL is associated with reduced adherence to PT but is not associated with adherence to SLPT among HNC survivors. These results highlight the clinical importance of HL and underscore the need for interventions to facilitate adherence to treatment for patients with inadequate HL. [ HLRP: Health Literacy Research and Practice . 2023;7(1):e52-e60. ].
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- 2023
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