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2. Long term health outcomes in people with diabetes 12 months after hospitalisation with COVID-19 in the UK: a prospective cohort study

Author

Brightling, C.E., Evans, R.A., Wain, L.V., Chalmers, J.D., Harris, V.C., Ho, L.P., Horsley, A., Marks, M., Poinasamy, K., Raman, B., Shikotra, A., Singapuri, A., Dowling, R., Edwardson, C., Elneima, O., Finney, S., Greening, N.J., Hargadon, B., Houchen--Wolloff, L., Leavy, O.C., McAuley, H.J.C., Overton, C., Plekhanova, T., Saunders, R.M., Sereno, M., Taylor, C., Terry, S., Tong, C., Zhao, B., Lomas, D., Sapey, E., Berry, C., Bolton, C.E., Brunskill, N., Chilvers, E.R., Djukanovic, R., Ellis, Y., Forton, D., French, N., George, J., Hanley, N.A., Hart, N., McGarvey, L., Maskell, N., McShane, H., Parkes, M., Peckham, D., Pfeffer, P., Sayer, A., Sheikh, A., Thompson, A.A.R., Williams, N., Greenhalf, W., Semple, M.G., Ashworth, M., Hardwick, H.E., Lavelle-Langham, L., Reynolds, W., Shaw, V., Venson, B., Docherty, A.B., Harrison, E.M., Baillie, J.K., Daines, L., Free, R., Kerr, S., Lone, N.I., Lozano-Rojas, D., Ntotsis, K., Pius, R., Quint, J., Richardson, M., Thorpe, M., Halling-Brown, M., Gleeson, F., Jacob, J., Neubauer, S., Siddiqui, S., Wild, J.M., Aslani, S., Baxter, G., Beggs, M., Bloomfield, C., Cassar, M.P., Chiribiri, A., Cox, E., Cuthbertson, D.J., Ferreira, V.M., Finnigan, L., Francis, S., Jezzard, P., Kemp, G.J., Lamlum, H., Lukaschuk, E., Manisty, C., McCann, G.P., McCracken, C., McGlynn, K., Menke, R., Miller, C.A., Moss, A.J., Nichols, T.E., Nikolaidou, C., O'Brien, C., Ogbole, G., Rangelov, B., O'Regan, D.P., Pakzad, A., Piechnik, S., Plein, S., Propescu, I., Samat, A.A., Saunders, L., Sanders, Z.B., Steeds, R., Treibel, T., Tunnicliffe, E.M., Webster, M., Willoughby, J., Weir McCall, J., Xie, C., Xu, M., Baxendale, H., Brown, M., Gooptu, B., Jenkins, R.G., Jones, D., Koychev, I., Langenberg, C., Lawrie, A., Molyneaux, P.L., Pearl, J., Ralser, M., Sattar, N., Scott, J.T., Shaw, T., Thomas, D., Wilkinson, D., Heaney, L.G., De Soyza, A., Adeloye, D., Brown, J.S., Busby, J., Echevarria, C., Hurst, J., Novotny, P., Nicolaou, C., Rudan, I., Shankar-Hari, M., Walker, S., Zheng, B., Geddes, J.R., Hotopf, M., Abel, K., Ahmed, R., Allan, L., Armour, C., Baguley, D., Baldwin, D., Ballard, C., Bhui, K., Breen, G., Breeze, K., Broome, M., Brugha, T., Bullmore, E., Burn, D., Callard, F., Cavanagh, J., Chalder, T., Clark, D., David, A., Deakin, B., Dobson, H., Elliott, B., Evans, J., Francis, R., Guthrie, E., Harrison, P., Henderson, M., Hosseini, A., Huneke, N., Husain, M., Jackson, T., Jones, I., Kabir, T., Kitterick, P., Korszun, A., Kwan, J., Lingford-Hughes, A., Mansoori, P., McAllister-Williams, H., McIvor, K., Michael, B., Milligan, L., Morriss, R., Mukaetova-Ladinska, E., Munro, K., Nevado-Holgado, A., Nicholson, T., Paddick, S., Pariante, C., Pimm, J., Saunders, K., Sharpe, M., Simons, G., Taylor, J.P., Upthegrove, R., Wessely, S., Amoils, S., Antoniades, C., Banerjee, A., Bularga, A., Chowienczyk, P., Greenwood, J.P., Hughes, A.D., Khunti, K., Lawson, C., Mills, N.L., Sattar, A.N., Sudlow, C.L., Toshner, M., Openshaw, P.J.M., Altmann, D., Batterham, R., Bishop, N., Calder, P.C., Efstathiou, C.M., Heeney, J.L., Hussell, T., Klenerman, P., Liew, F., Lord, J.M., Moss, P., Rowland-Jones, S.L., Schwaeble, W., Thwaites, R.S., Turtle, L., Walmsley, S., Wraith, D., Rowland, M.J., Rostron, A., Connolly, B., McAuley, D.F., Parekh, D., Simpson, J., Summers, C., Porter, J., Allen, R.J., Aul, R., Barratt, S., Beirne, P., Blaikley, J., Chambers, R.C., Chaudhuri, N., Coleman, C., Denneny, E., Fabbri, L., George, P.M., Gibbons, M., Guillen Guio, B., Hall, I., Hufton, E., Jarrold, I., Jenkins, G., Johnson, S., Jones, M.G., Jones, S., Khan, F., Mehta, P., Mitchell, J., Pearl, J.E., Piper Hanley, K., Rivera-Ortega, P., Saunders, L.C., Smith, D., Spears, M., Spencer, L.G., Stanel, S., Stewart, I., Thickett, D., Thwaites, R., Walsh, S., Wootton, D.G., Wright, L., Heller, S., Davies, M.J., Atkins, H., Bain, S., Dennis, J., Ismail, K., Johnston, D., Kar, P., McArdle, P., McGovern, A., Peto, T., Petrie, J., Robertson, E., Shah, K., Valabhji, J., Young, B., Howard, L.S., Toshner, Mark, Newman, J., Price, L., Reddy, A., Rossdale, J., Sudlow, C., Wilkins, M., Singh, S.J., Man, W.D.-C., Armstrong, N., Baldry, E., Baldwin, M., Basu, N., Beadsworth, M., Bishop, L., Briggs, A., Buch, M., Carson, G., Chinoy, H., Dawson, C., Daynes, E., Defres, S., Gardiner, L., Greenhaff, P., Greenwood, S., Harvie, M., HOuchen-Wolloff, L., MacDonald, S., McArdle, A., McMahon, A., McNarry, M., Mills, G., Nolan, C., O'Donnell, K., Pimm, Sargent, J., Sigfrid, L., Steiner, M., Stensel, D., Tan, A.L., Vogiatzis, I., Whitney, J., Wilson, D., Witham, M., Yates, T., Laing, C., Bramham, K., Chowdhury, P., Frankel, A., Lightstone, L., McAdoo, S., McCafferty, K., Ostermann, M., Selby, N., Sharpe, C., Willicombe, M., Houchen-Wolloff, L., Bunker, J., Gill, R., Hastie, C., Nathu, R., Rogers, N., Smith, N., Shaw, A., Armstrong, L., Hairsine, B., Henson, H., Kurasz, C., Shenton, L., Fairbairn, S., Dell, A., Hawkings, N., Haworth, J., Hoare, M., Lucey, A., Lewis, V., Mallison, G., Nassa, H., Pennington, C., Price, A., Price, C., Storrie, A., Willis, G., Young, S., Chong-James, K., David, C., James, W.Y., Martineau, A., Zongo, O., Sanderson, A., Brown, V., Craig, T., Drain, S., King, B., Magee, N., McAulay, D., Major, E., McGinness, J., Stone, R., Haggar, A., Bolger, A., Davies, F., Lewis, J., Lloyd, A., Manley, R., McIvor, E., Menzies, D., Roberts, K., Saxon, W., Southern, D., Subbe, C., Whitehead, V., El-Taweel, H., Dawson, J., Robinson, L., Saralaya, D., Brear, L., Regan, K., Storton, K., Fuld, J., Bermperi, A., Cruz, I., Dempsey, K., Elmer, A., Jones, H., Jose, S., Marciniak, S., Ribeiro, C., Taylor, J., Watson, L., Worsley, J., Sabit, R., Broad, L., Buttress, A., Evans, T., Haynes, M., Jones, L., Knibbs, L., McQueen, A., Oliver, C., Paradowski, K., Williams, J., Harris, E., Sampson, C., Lynch, C., Davies, E., Evenden, C., Hancock, A., Hancock, K., Rees, M., Roche, L., Stroud, N., Thomas-Woods, T., Babores, M., Bradley-Potts, J., Holland, M., Keenan, N., Shashaa, S., Wassall, H., Beranova, E., Weston, H., Cosier, T., Austin, L., Deery, J., Hazelton, T., Ramos, H., Solly, R., Turney, S., Pearce, L., McCormick, W., Pugmire, S., Stoker, W., Wilson, A., Aguilar Jimenez, L.A., Arbane, G., Betts, S., Bisnauthsing, K., Dewar, A., Kaltsakas, G., Kerslake, H., Magtoto, M.M., Marino, P., Martinez, L.M., Solano, T.S., Wynn, E., Storrar, W., Alvarez Corral, M., Arias, A., Bevan, E., Griffin, D., Martin, J., Owen, J., Payne, S., Prabhu, A., Reed, A., Wrey Brown, C., Burdett, T., Featherstone, J., Layton, A., Mills, C., Stephenson, L., Easom, N., Atkin, P., Brindle, K., Crooks, M.G., Drury, K., Flockton, R., Holdsworth, L., Richards, A., Sykes, D.L., Thackray-Nocera, S., Wright, C., Lewis, K.E., Mohamed, A., Ross, G., Coetzee, S., Davies, K., Hughes, R., Loosley, R., O'Brien, L., Omar, Z., McGuinness, H., Perkins, E., Phipps, J., Taylor, A., Tench, H., Wolf-Roberts, R., Kon, O., Thomas, D.C., Anifowose, S., Burden, L., Calvelo, E., Card, B., Carr, C., Copeland, D., Cullinan, P., Daly, P., Evison, L., Fayzan, T., Gordon, H., Haq, S., King, C., March, K., Mariveles, M., McLeavey, L., Mohamed, N., Moriera, S., Munawar, U., Nunag, J., Nwanguma, U., Orriss-Dib, L., Ross, A., Roy, M., Russell, E., Samuel, K., Schronce, J., Simpson, N., Tarusan, L., Wood, C., Yasmin, N., Reddy, R., Guerdette, A.-M., Hewitt, M., Warwick, K., White, S., Shah, A.M., Jolley, C.J., Adeyemi, O., Adrego, R., Assefa-Kebede, H., Breeze, J., Byrne, S., Dulawan, P., Hayday, A., Hoare, A., Knighton, A., Malim, M., Patale, S., Peralta, I., Powell, N., Ramos, A., Shevket, K., Speranza, F., Te, A., Ashworth, A., Clarke, J., Coupland, C., Dalton, M., Wade, E., Favager, C., Greenwood, J., Glossop, J., Hall, L., Hardy, T., Humphries, A., Murira, J., Rangeley, J., Saalmink, G., Whittam, B., Window, N., Woods, J., Coakley, G., Allerton, L., Berridge, A., Brown, J., Cooper, S., Cross, A., Dobson, S.L., Earley, J., Hainey, K., Hawkes, J., Highett, V., Kaprowska, S., Key, A.L., Koprowska, S., Lewis-Burke, N., Madzamba, G., Malein, F., Marsh, S., Mears, C., Melling, L., Noonan, M.J., Poll, L., Pratt, J., Richardson, E., Rowe, A., Tripp, K.A., Vinson, B., Wajero, L.O., Williams-Howard, S.A., Wyles, J., Diwanji, S.N., Papineni, P., Gurram, S., Quaid, S., Tiongson, G.F., Watson, E., Al-Sheklly, B., Avram, C., Barran, P., Blaikely, J., Choudhury, N., Faluyi, D., Felton, T., Gorsuch, T., Kausar, Z., Odell, N., Osbourne, R., Radhakrishnan, K., Stockdale, S., Trivedi, D., Ayoub, A., Burns, G., Davies, G., Fisher, H., Francis, C., Greenhalgh, A., Hogarth, P., Hughes, J., Jiwa, K., Jones, G., MacGowan, G., Price, D., Tedd, H., Thomas, S., West, S., Wright, S., Young, A., McMahon, M.J., Neill, P., Anderson, D., Bayes, H., Grieve, D., McInnes, I.B., Brown, A., Dougherty, A., Fallon, K., Gilmour, L., Mangion, K., Morrow, A., Scott, K., Sykes, R., Touyz, R., Sage, E.K., Barrett, F., Donaldson, A., Patel, M., Bell, D., Hamil, R., Leitch, K., Macliver, L., Quigley, J., Smith, A., Welsh, B., Choudhury, G., Clohisey, S., Deans, A., Furniss, J., Kelly, S., Newby, D.E., Connell, D., Elliott, A., Deas, C., Mohammed, S., Rowland, J., Solstice, A.R., Sutherland, D., Tee, C.J., Arnold, D., Barrett, S., Adamali, H., Dipper, A., Dunn, S., Morley, A., Morrison, L., Stadon, L., Waterson, S., Welch, H., Jayaraman, B., Light, T., Almeida, P., Bonnington, J., Chrystal, M., Dupont, C., Gupta, A., Howard, L., Jang, W., Linford, S., Matthews, L., Needham, R., Nikolaidis, A., Prosper, S., Shaw, K., Thomas, A.K., Rahman, N.M., Ainsworth, M., Alamoudi, A., Bates, A., Bloss, A., Burns, A., Carter, P., Cassar, M., Channon, K.M., Chen, J., Conneh, F., Dong, T., Evans, R.I., Fraser, E., Fu, X., Havinden-Williams, M., Kanellakis, N., Kurupati, P., Li, X., Megson, C., Motohashi, K., Nicoll, D., Ogg, G., Pacpaco, E., Pavlides, M., Peng, Y., Petousi, N., Propescu, J., Rahman, N., Talbot, N., Tunnicliffe, E., Patel, B., Barker, R.E., Cristiano, D., Dormand, N., Gummadi, M., Kon, S., Liyanage, K., Nolan, C.M., Patel, S., Polgar, O., Shah, P., Walsh, J.A., Jarvis, H., Mandal, S., Ahmad, S., Brill, S., Lim, L., Matila, D., Olaosebikan, O., Singh, C., Garner, L., Johnson, C., Mackie, J., Michael, A., Pack, J., Paques, K., Parfrey, H., Parmar, J., Diar Bakerly, N., Dark, P., Evans, D., Hardy, E., Harvey, A., Holgate, D., Knight, S., Mairs, N., Majeed, N., McMorrow, L., Oxton, J., Pendlebury, J., Summersgill, C., Ugwuoke, R., Whittaker, S., Matimba-Mupaya, W., Strong-Sheldrake, S., Bagshaw, J., Begum, M., Birchall, K., Butcher, R., Carborn, H., Chan, F., Chapman, K., Cheng, Y., Chetham, L., Clark, C., Coburn, Z., Cole, J., Dixon, M., Fairman, A., Finnigan, J., Foot, H., Foote, D., Ford, A., Gregory, R., Harrington, K., Haslam, L., Hesselden, L., Hockridge, J., Holbourn, A., Holroyd-Hind, B., Holt, L., Howell, A., Hurditch, E., Ilyas, F., Jarman, C., Lee, E., Lee, J.-H., Lenagh, R., Lye, A., Macharia, I., Marshall, M., Mbuyisa, A., McNeill, J., Megson, S., Meiring, J., Milner, L., Misra, S., Newell, H., Newman, T., Norman, C., Nwafor, L., Pattenadk, D., Plowright, M., Ravencroft, P., Roddis, C., Rodger, J., Saunders, P., Sidebottom, J., Smith, J., Smith, L., Steele, N., Stephens, G., Stimpson, R., Thamu, B., Tinker, N., Turner, K., Turton, H., Wade, P., Watson, J., Wilson, I., Zawia, A., Ali, M., Dunleavy, A., Msimanga, N., Mencias, M., Samakomva, T., Siddique, S., Teixeira, J., Tavoukjian, V., Hutchinson, J., Allsop, L., Bennett, K., Buckley, P., Flynn, M., Gill, M., Goodwin, C., Greatorex, M., Gregory, H., Heeley, C., Holloway, L., Holmes, M., Kirk, J., Lovegrove, W., Sewell, T.A., Shelton, S., Sissons, D., Slack, K., Smith, S., Sowter, D., Turner, S., Whitworth, V., Wynter, I., Warburton, L., Painter, S., Tomlinson, J., Vickers, C., Wainwright, T., Redwood, D., Tilley, J., Palmer, S., Davies, G.A., Connor, L., Cook, A., Rees, T., Thaivalappil, F., Thomas, C., Butt, A., Coulding, M., Kilroy, S., McCormick, J., McIntosh, J., Savill, H., Turner, V., Vere, J., Fraile, E., Ugoji, J., Kon, S.S., Lota, H., Landers, G., Nasseri, M., Portukhay, S., Hormis, A., Daniels, A., Ingham, J., Zeidan, L., Chablani, M., Osborne, L., Ahwireng, N., Bang, B., Basire, D., Checkley, A., Evans, R., Heightman, M., Hillman, T., Janes, S., Jastrub, R., Lipman, M., Logan, S., Merida Morillas, M., Plant, H., Porter, J.C., Roy, K., Wall, E., Williams, B., Ahmad Haider, N., Atkin, C., Baggott, R., Bates, M., Botkai, A., Casey, A., Cooper, B., Dasgin, J., Draxlbauer, K., Gautam, N., Hazeldine, J., Hiwot, T., Holden, S., Isaacs, K., Kamwa, V., Lewis, D., Madathil, S., McGhee, C., Mcgee, K., Neal, A., Newton Cox, A., Nyaboko, J., Peterkin, Z., Qureshi, H., Ratcliffe, L., Short, J., Soulsby, T., Stockley, J., Suleiman, Z., Thompson, T., Ventura, M., Walder, S., Welch, C., Yasmin, S., Yip, K.P., Beckett, P., Dickens, C., Nanda, U., Aljaroof, M., Arnold, H., Aung, H., Bakali, M., Bakau, M., Bingham, M., Bourne, M., Bourne, C., Cairns, P., Carr, L., Charalambou, A., Christie, C., Diver, S., Edwards, S., Evans, H., Finch, J., Glover, S., Goodman, N., Gootpu, B., Hadley, K., Haldar, P., Ibrahim, W., Ingram, L., Lea, A., Lee, D., McCourt, P., Mcnally, T., Moss, A., Monteiro, W., Pareek, M., Parker, S., Rowland, A., Prickett, A., Qureshi, I.N., Russell, R., Samani, N., Sharma, M., Skeemer, J., Soares, M., Stringer, E., Thornton, T., Tobin, M., Turner, E., Ward, T.J.C., Woodhead, F., Wormleighton, J., Yousuf, A., Childs, C., Fletcher, S., Harvey, M., Marouzet, E., Marshall, B., Samuel, R., Sass, T., Wallis, T., Wheeler, H., Dharmagunawardena, R., Bright, E., Crisp, P., Stern, M., Wight, A., Bailey, L., Reddington, A., Ashish, A., Cooper, J., Robinson, E., Broadley, A., Howard, K., Barman, L., Brookes, C., Elliott, K., Griffiths, L., Guy, Z., Ionita, D., Redfearn, H., Sarginson, C., Turnbull, A., Holmes, K., Lewis, K., Gharibzadeh, Safoora, Routen, Ash, Razieh, Cameron, Zaccardi, Francesco, Lawson, Claire, Gillies, Clare, Heller, Simon, Davies, Melanie, Atkins, Helen, Bain, Stephen C., Lone, Nazir L., Poinasamy, Krisnah, Peto, Tunde, Robertson, Elizabeth, Young, Bob, Johnston, Desmond, Quint, Jennifer, Valabhji, Jonathan, Ismail, Khalida, Marks, Michael, Horsley, Alex, Docherty, Annemarie, Harrison, Ewen, Chalmers, James, Ho, Ling-Pei, Raman, Betty, Brightling, Chris, Elneima, Omer, Evans, Rachel, Greening, Neil, Harris, Victoria C., Houchen-Wolloff, Linzy, Sereno, Marco, Shikotra, Aarti, Singapuri, Amisha, Wain, Louise, Langenberg, Claudia, Dennis, John, Petrie, John, Sattar, Naveed, Leavy, Olivia, Richardson, Mattew, Saunders, Ruth M., McArdle, Anne, McASuley, Hamish, Yates, Tom, and Khunti, Kamlesh

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2025
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3. Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study

Author

Abel, K, Adamali, H, Adeloye, D, Adeyemi, O, Adeyemi, F, Ahmad, S, Ahmed, R, Ainsworth, M, Al-Sheklly, B, Alamoudi, A, Aljaroof, M, Allan, L, Allen, R, Alli, A, Altmann, D, Anderson, D, Andrews, M, Angyal, A, Antoniades, C, Arbane, G, Armour, C, Armstrong, N, Armstrong, L, Arnold, H, Arnold, D, Ashworth, M, Ashworth, A, Assefa-Kebede, H, Atkin, P, Atkins, H, Atkins, A, Aul, R, Avram, C, Baggott, R, Baguley, D, Baillie, J K, Bain, S, Bakali, M, Bakau, M, Baldry, E, Baldwin, D, Ballard, C, Bambrough, J, Barker, R E, Barratt, S, Barrett, F, Basire, D, Basu, N, Batterham, R, Baxendale, H, Bayes, H, Bayley, M, Beadsworth, M, Beirne, P, Bell, R, Bell, D, Berry, C, Betts, S, Bhui, K, Bishop, L, Blaikely, J, Bloomfield, C, Bloss, A, Bolger, A, Bolton, C E, Bonnington, J, Botkai, A, Bourne, M, Bourne, C, Bradley, E, Bramham, K, Brear, L, Breen, G, Breeze, J, Briggs, A, Bright, E, Brightling, C E, Brill, S, Brindle, K, Broad, L, Broome, M, Brown, J S, Brown, M, Brown, J, Brown, R, Brown, V, Brown, A, Brugha, T, Brunskill, N, Buch, M, Bularga, A, Bullmore, E, Burn, D, Burns, G, Busby, J, Buttress, A, Byrne, S, Cairns, P, Calder, P C, Calvelo, E, Card, B, Carr, L, Carson, G, Carter, P, Cavanagh, J, Chalder, T, Chalmers, J D, Chambers, R C, Channon, K, Chapman, K, Charalambou, A, Chaudhuri, N, Checkley, A, Chen, J, Chetham, L, Chilvers, E R, Chinoy, H, Chong-James, K, Choudhury, N, Choudhury, G, Chowdhury, P, Chowienczyk, P, Christie, C, Clark, D, Clark, C, Clarke, J, Clift, P, Clohisey, S, Coburn, Z, Cole, J, Coleman, C, Connell, D, Connolly, B, Connor, L, Cook, A, Cooper, B, Coupland, C, Craig, T, Crisp, P, Cristiano, D, Crooks, M G, Cross, A, Cruz, I, Cullinan, P, Daines, L, Dalton, M, Dark, P, Dasgin, J, David, A, David, C, Davies, M, Davies, G, Davies, K, Davies, F, Davies, G A, Daynes, E, De Silva, T, De Soyza, A, Deakin, B, Deans, A, Defres, S, Dell, A, Dempsey, K, Dennis, J, Dewar, A, Dharmagunawardena, R, Diar Bakerly, N, Dipper, A, Diver, S, Diwanji, S N, Dixon, M, Djukanovic, R, Dobson, H, Dobson, C, Dobson, S L, Docherty, A B, Donaldson, A, Dong, T, Dormand, N, Dougherty, A, Dowling, R, Drain, S, Dulawan, P, Dunleavy, A, Dunn, S, Easom, N, Echevarria, C, Edwards, S, Edwardson, C, Elliott, B, Elliott, A, Ellis, Y, Elmer, A, Elneima, O, Evans, R A, Evans, J, Evans, H, Evans, D, Evans, R I, Evans, R, Evans, T, Fabbri, L, Fairbairn, S, Fairman, A, Fallon, K, Faluyi, D, Favager, C, Felton, T, Finch, J, Finney, S, Fisher, H, Fletcher, S, Flockton, R, Foote, D, Ford, A, Forton, D, Francis, R, Francis, S, Francis, C, Frankel, A, Fraser, E, Free, R, French, N, Fuld, J, Furniss, J, Garner, L, Gautam, N, Geddes, J R, George, P M, George, J, Gibbons, M, Gilmour, L, Gleeson, F, Glossop, J, Glover, S, Goodman, N, Gooptu, B, Gorsuch, T, Gourlay, E, Greenhaff, P, Greenhalf, W, Greenhalgh, A, Greening, N J, Greenwood, J, Greenwood, S, Gregory, R, Grieve, D, Gummadi, M, Gupta, A, Gurram, S, Guthrie, E, Hadley, K, Haggar, A, Hainey, K, Haldar, P, Hall, I, Hall, L, Halling-Brown, M, Hamil, R, Hanley, N A, Hardwick, H E, Hardy, E, Hargadon, B, Harrington, K, Harris, V, Harrison, E M, Harrison, P, Hart, N, Harvey, A, Harvey, M, Harvie, M, Havinden-Williams, M, Hawkes, J, Hawkings, N, Haworth, J, Hayday, A, Heaney, L G, Heeney, J L, Heightman, M, Heller, S, Henderson, M, Hesselden, L, Hillman, T, Hingorani, A, Hiwot, T, Ho, L P, Hoare, A, Hoare, M, Hogarth, P, Holbourn, A, Holdsworth, L, Holgate, D, Holmes, K, Holroyd-Hind, B, Horsley, A, Hosseini, A, Hotopf, M, Houchen, L, Howard, L, Howell, A, Hufton, E, Hughes, A, Hughes, J, Hughes, R, Humphries, A, Huneke, N, Hurst, J R, Hurst, R, Husain, M, Hussell, T, Ibrahim, W, Ient, A, Ingram, L, Ismail, K, Jackson, T, Jacob, J, James, W Y, Janes, S, Jarvis, H, Jayaraman, B, Jenkins, R G, Jezzard, P, Jiwa, K, Johnson, S, Johnson, C, Johnston, D, Jolley, C, Jolley, C J, Jones, I, Jones, S, Jones, D, Jones, H, Jones, G, Jones, M, Jose, S, Kabir, T, Kaltsakas, G, Kamwa, V, Kar, P, Kausar, Z, Kelly, S, Kerr, S, Key, A L, Khan, F, Khunti, K, King, C, King, B, Kitterick, P, Klenerman, P, Knibbs, L, Knight, S, Knighton, A, Kon, O M, Kon, S, Kon, S S, Korszun, A, Kotanidis, C, Koychev, I, Kurupati, P, Kwan, J, Laing, C, Lamlum, H, Landers, G, Langenberg, C, Lasserson, D, Lawrie, A, Lea, A, Leavy, O C, Lee, D, Lee, E, Leitch, K, Lenagh, R, Lewis, K, Lewis, V, Lewis, K E, Lewis, J, Lewis-Burke, N, Light, T, Lightstone, L, Lim, L, Linford, S, Lingford-Hughes, A, Lipman, M, Liyanage, K, Lloyd, A, Logan, S, Lomas, D, Lone, N I, Loosley, R, Lord, J M, Lota, H, Lucey, A, MacGowan, G, Macharia, I, Mackay, C, Macliver, L, Madathil, S, Madzamba, G, Magee, N, Mairs, N, Majeed, N, Major, E, Malim, M, Mallison, G, Man, W, Mandal, S, Mangion, K, Mansoori, P, Marciniak, S, Mariveles, M, Marks, M, Marshall, B, Martineau, A, Maskell, N, Matila, D, Matthews, L, Mayet, J, McAdoo, S, McAllister-Williams, H, McArdle, P, McArdle, A, McAulay, D, McAuley, H J C, McAuley, D F, McCafferty, K, McCann, G P, McCauley, H, McCourt, P, Mcgarvey, L, McGinness, J, McGovern, A, McGuinness, H, McInnes, I B, McIvor, K, McIvor, E, McMahon, A, McMahon, M J, McMorrow, L, Mcnally, T, McNarry, M, McQueen, A, McShane, H, Megson, S, Meiring, J, Menzies, D, Michael, A, Michael, B D, Milligan, L, Mills, N, Mitchell, J, Mohamed, A, Molyneaux, P L, Monteiro, W, Morley, A, Morrison, L, Morriss, R, Morrow, A, Moss, A, Moss, A J, Moss, P, Mukaetova-Ladinska, E, Munawar, U, Murali, E, Murira, J, Nassa, H, Neill, P, Neubauer, S, Newby, D, Newell, H, Newton Cox, A, Nicholson, T, Nicoll, D, Nolan, C M, Noonan, M J, Novotny, P, Nunag, J, Nyaboko, J, O'Brien, L, Odell, N, Ogg, G, Olaosebikan, O, Oliver, C, Omar, Z, Openshaw, P J M, Osbourne, R, Ostermann, M, Overton, C, Oxton, J, Pacpaco, E, Paddick, S, Papineni, P, Paradowski, K, Pareek, M, Parekh, D, Parfrey, H, Pariante, C, Parker, S, Parkes, M, Parmar, J, Parvin, R, Patale, S, Patel, B, Patel, S, Patel, M, Pathmanathan, B, Pavlides, M, Pearl, J E, Peckham, D, Pendlebury, J, Peng, Y, Pennington, C, Peralta, I, Perkins, E, Peto, T, Petousi, N, Petrie, J, Pfeffer, P, Phipps, J, Pimm, J, Piper Hanley, K, Pius, R, Plein, S, Plekhanova, T, Poinasamy, K, Polgar, O, Poll, L, Porter, J C, Portukhay, S, Powell, N, Price, L, Price, D, Price, A, Price, C, Prickett, A, Quaid, S, Quigley, J, Quint, J, Qureshi, H, Rahman, N, Rahman, M, Ralser, M, Raman, B, Ramos, A, Rangeley, J, Rees, T, Regan, K, Richards, A, Richardson, M, Rivera-Ortega, P, Robertson, E, Rodgers, J, Ross, G, Rossdale, J, Rostron, A, Routen, A, Rowland, A, Rowland, M J, Rowland, J, Rowland-Jones, S L, Roy, K, Rudan, I, Russell, R, Russell, E, Sabit, R, Sage, E K, Samani, N, Samuel, R, Sapey, E, Saralaya, D, Saratzis, A, Sargeant, J, Sass, T, Sattar, N, Saunders, K, Saunders, R, Saxon, W, Sayer, A, Schwaeble, W, Scott, J, Scott, K, Selby, N, Semple, M G, Sereno, M, Shah, K, Shah, A, Shah, P, Sharma, M, Sharpe, M, Sharpe, C, Shaw, V, Sheikh, A, Shevket, K, Shikotra, A, Short, J, Siddiqui, S, Sigfrid, L, Simons, G, Simpson, J, Singapuri, A, Singh, S J, Singh, C, Singh, S, Skeemer, J, Smith, I, Smith, J, Smith, L, Smith, A, Soares, M, Southern, D, Spears, M, Spencer, L G, Speranza, F, Stadon, L, Stanel, S, Steiner, M, Stensel, D, Stern, M, Stewart, I, Stockley, J, Stone, R, Storrie, A, Storton, K, Stringer, E, Subbe, C, Sudlow, C, Suleiman, Z, Summers, C, Summersgill, C, Sutherland, D, Sykes, D L, Sykes, R, Talbot, N, Tan, A L, Taylor, C, Taylor, A, Te, A, Tedd, H, Tee, C J, Tench, H, Terry, S, Thackray-Nocera, S, Thaivalappil, F, Thickett, D, Thomas, D, Thomas, D C, Thomas, A K, Thompson, A A R, Thompson, T, Thornton, T, Thwaites, R S, Tobin, M, Toingson, G F, Tong, C, Toshner, M, Touyz, R, Tripp, K A, Tunnicliffe, E, Turner, E, Turtle, L, Turton, H, Ugwuoke, R, Upthegrove, R, Valabhji, J, Vellore, K, Wade, E, Wain, L V, Wajero, L O, Walder, S, Walker, S, Wall, E, Wallis, T, Walmsley, S, Walsh, S, Walsh, J A, Watson, L, Watson, J, Watson, E, Welch, C, Welch, H, Welsh, B, Wessely, S, West, S, Wheeler, H, Whitehead, V, Whitney, J, Whittaker, S, Whittam, B, Wild, J, Wilkins, M, Wilkinson, D, Williams, N, Williams, B, Williams, J, Williams-Howard, S A, Willicombe, M, Willis, G, Wilson, D, Wilson, I, Window, N, Witham, M, Wolf-Roberts, R, Woodhead, F, Woods, J, Wootton, D, Worsley, J, Wraith, D, Wright, L, Wright, C, Wright, S, Xie, C, Yasmin, S, Yates, T, Yip, K P, Young, B, Young, S, Young, A, Yousuf, A J, Yousuf, A, Zawia, A, Zhao, B, Zongo, O, Evans, Rachael A, McAuley, Hamish J C, Harrison, Ewen M, Shikotra, Aarti, Singapuri, Amisha, Sereno, Marco, Elneima, Omer, Docherty, Annemarie B, Lone, Nazir I, Leavy, Olivia C, Daines, Luke, Baillie, J Kenneth, Brown, Jeremy S, Chalder, Trudie, De Soyza, Anthony, Diar Bakerly, Nawar, Easom, Nicholas, Geddes, John R, Greening, Neil J, Hart, Nick, Heaney, Liam G, Heller, Simon, Howard, Luke, Hurst, John R, Jacob, Joseph, Jenkins, R Gisli, Jolley, Caroline, Kerr, Steven, Kon, Onn M, Lewis, Keir, Lord, Janet M, McCann, Gerry P, Neubauer, Stefan, Openshaw, Peter J M, Parekh, Dhruv, Pfeffer, Paul, Rahman, Najib M, Raman, Betty, Richardson, Matthew, Rowland, Matthew, Semple, Malcolm G, Shah, Ajay M, Singh, Sally J, Sheikh, Aziz, Thomas, David, Toshner, Mark, Chalmers, James D, Ho, Ling-Pei, Horsley, Alex, Marks, Michael, Poinasamy, Krisnah, Wain, Louise V, and Brightling, Christopher E

Published
2021
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5. Effectiveness of autologous haematopoietic stem cell transplantation versus natalizumab in progressive multiple sclerosis

Author

Kalincik, T, Sharmin, S, Massey, J, Sutton, I, Withers, B, Freedman, MS, Atkins, H, Krasulova, E, Havrdova, EK, Trneny, M, Kozak, T, Burman, J, MacDonell, R, Torkildsen, Ø, Bø, L, Lehmann, AK, Sharrack, B, Snowden, J, Kalincik, T, Sharmin, S, Massey, J, Sutton, I, Withers, B, Freedman, MS, Atkins, H, Krasulova, E, Havrdova, EK, Trneny, M, Kozak, T, Burman, J, MacDonell, R, Torkildsen, Ø, Bø, L, Lehmann, AK, Sharrack, B, and Snowden, J

Abstract

Background: Natalizumab was not shown to modify disability in progressive multiple sclerosis (MS). This matched observational study compared the effectiveness of autologous hematopoietic stem cell transplantation (AHSCT) with natalizumab in progressive MS. Methods: Patients with primary/secondary progressive MS from 7 AHSCT MS centres and the MSBase registry, treated with AHSCT or natalizumab were matched on a propensity score derived from sex, age, Expanded Disability Status Scale (EDSS), number of relapses 12/24 months before baseline, time from MS onset, the most effective prior therapy and country. The pairwise- censored groups were compared on hazards of 6-month confirmed EDSS worsening and improvement, relapses and annualised relapse rates (ARR), using Andersen-Gill proportional hazards models and conditional negative binomial model. Findings: 39 patients treated with AHSCT (37 with secondary progressive MS, mean age 37 years, EDSS 5.7, 28% with recent disability progression, ARR 0.54 during the preceding year) were matched with 65 patients treated with natalizumab. The study found no evidence for difference in hazards of confirmed EDSS worsening (hazard ratio 1.49, 95% confidence interval [95%CI] 0.70-3.14) and improvement (hazard ratio 1.50, 95%CI 0.22-10.29) between AHSCT and natalizumab over up to 4 years. The relapse activity was also similar while treated with AHSCT and natalizumab (ARR: mean±standard deviation 0.08±0.28 vs. 0.08±0.25; hazard ratio 1.05, 95%CI 0.39-2.82). In the AHSCT group, 3 patients experienced febrile neutropenia during mobilisation, 9 patients experienced serum sickness, 6 patients required ICU admission, and 36 patients experienced complications after discharge. No treatment-related deaths were reported. Conclusion: This study does not support the use of AHSCT to control disability in progressive MS with advanced disability and low relapse activity.

Published
2024

9. Comparative Effectiveness of Autologous Hematopoietic Stem Cell Transplant vs Fingolimod, Natalizumab, and Ocrelizumab in Highly Active Relapsing-Remitting Multiple Sclerosis

Author

Kalincik, T, Sharmin, S, Roos, I, Freedman, MS, Atkins, H, Burman, J, Massey, J, Sutton, I, Withers, B, Macdonell, R, Grigg, A, Torkildsen, O, Bo, L, Lehmann, AK, Havrdova, EK, Krasulova, E, Trneny, M, Kozak, T, van der Walt, A, Butzkueven, H, McCombe, P, Skibina, O, Lechner-Scott, J, Willekens, B, Cartechini, E, Ozakbas, S, Alroughani, R, Kuhle, J, Patti, F, Duquette, P, Lugaresi, A, Khoury, SJ, Slee, M, Turkoglu, R, Hodgkinson, S, John, N, Maimone, D, Sa, MJ, van Pesch, V, Gerlach, O, Laureys, G, Van Hijfte, L, Karabudak, R, Spitaleri, D, Csepany, T, Gouider, R, Castillo-Trivino, T, Taylor, B, Sharrack, B, Snowden, JA, Kalincik, T, Sharmin, S, Roos, I, Freedman, MS, Atkins, H, Burman, J, Massey, J, Sutton, I, Withers, B, Macdonell, R, Grigg, A, Torkildsen, O, Bo, L, Lehmann, AK, Havrdova, EK, Krasulova, E, Trneny, M, Kozak, T, van der Walt, A, Butzkueven, H, McCombe, P, Skibina, O, Lechner-Scott, J, Willekens, B, Cartechini, E, Ozakbas, S, Alroughani, R, Kuhle, J, Patti, F, Duquette, P, Lugaresi, A, Khoury, SJ, Slee, M, Turkoglu, R, Hodgkinson, S, John, N, Maimone, D, Sa, MJ, van Pesch, V, Gerlach, O, Laureys, G, Van Hijfte, L, Karabudak, R, Spitaleri, D, Csepany, T, Gouider, R, Castillo-Trivino, T, Taylor, B, Sharrack, B, and Snowden, JA

Abstract

IMPORTANCE: Autologous hematopoietic stem cell transplant (AHSCT) is available for treatment of highly active multiple sclerosis (MS). OBJECTIVE: To compare the effectiveness of AHSCT vs fingolimod, natalizumab, and ocrelizumab in relapsing-remitting MS by emulating pairwise trials. DESIGN, SETTING, AND PARTICIPANTS: This comparative treatment effectiveness study included 6 specialist MS centers with AHSCT programs and international MSBase registry between 2006 and 2021. The study included patients with relapsing-remitting MS treated with AHSCT, fingolimod, natalizumab, or ocrelizumab with 2 or more years study follow-up including 2 or more disability assessments. Patients were matched on a propensity score derived from clinical and demographic characteristics. EXPOSURE: AHSCT vs fingolimod, natalizumab, or ocrelizumab. MAIN OUTCOMES: Pairwise-censored groups were compared on annualized relapse rates (ARR) and freedom from relapses and 6-month confirmed Expanded Disability Status Scale (EDSS) score worsening and improvement. RESULTS: Of 4915 individuals, 167 were treated with AHSCT; 2558, fingolimod; 1490, natalizumab; and 700, ocrelizumab. The prematch AHSCT cohort was younger and with greater disability than the fingolimod, natalizumab, and ocrelizumab cohorts; the matched groups were closely aligned. The proportion of women ranged from 65% to 70%, and the mean (SD) age ranged from 35.3 (9.4) to 37.1 (10.6) years. The mean (SD) disease duration ranged from 7.9 (5.6) to 8.7 (5.4) years, EDSS score ranged from 3.5 (1.6) to 3.9 (1.9), and frequency of relapses ranged from 0.77 (0.94) to 0.86 (0.89) in the preceding year. Compared with the fingolimod group (769 [30.0%]), AHSCT (144 [86.2%]) was associated with fewer relapses (ARR: mean [SD], 0.09 [0.30] vs 0.20 [0.44]), similar risk of disability worsening (hazard ratio [HR], 1.70; 95% CI, 0.91-3.17), and higher chance of disability improvement (HR, 2.70; 95% CI, 1.71-4.26) over 5 years. Compared with natalizumab (730

Published
2023

12. Comparative effectiveness of autologous haematopoietic stem cell transplantation vs. fingolimod, ocrelizumab and natalizumab in relapsing-remitting MS

Author

Atkins, H., Burman, J., Massey, J., Sutton, I., Withers, B., Macdonell, R., Grigg, A., Torkildsen, O., Bo, L., Lehmann, A., Horakova, D., Havrdova, E., Krasulova, E., Trneny, M., Kozak, T., van der Walt, A., Butzkueven, H., McCombe, P., Van Wijmeersch, B., Buzzard, K., Skibina, O., Lechner-Scott, J., Willekens, B., Barnett, M., Cartechini, E., Ozakbas, S., Alroughani, R., Izquierdo, G., Boz, C., Kalincik, T., Sharman, S., Roos, I., Freedman, M., Eichau, S., Snowden, J., Sharrack, B., Turkoglu, R., Prevost, J., Slee, M., Soysal, A., Khoury, S., Lugaresi, A., Onofrj, M., Grammond, P., Duquette, P., Girard, M., Prat, A., Terzi, M., Patti, F., and Kuhle, J.

Published
2022

15. POSC363 Engaging Patients and Caregivers in Health Economic Evaluations: Generating Stakeholder Input to Inform the Conduct of an Early Economic Evaluation of Chimeric Antigen Receptor T-Cell Therapy

Author

Wilson, M, primary, Thavorn, K, additional, Hawrysh, T, additional, Graham, ID, additional, Atkins, H, additional, Kekre, N, additional, Coyle, D, additional, Lalu, MM, additional, Fergusson, DA, additional, Chan, KKW, additional, Ollendorf, DA, additional, and Presseau, J, additional

Published
2022
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18. Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study

Author

Evans, Rachael A, primary, McAuley, Hamish, additional, Harrison, Ewen M, additional, Shikotra, Aarti, additional, Singapuri, Amisha, additional, Sereno, Marco, additional, Elneima, Omer, additional, Docherty, Annemarie B, additional, Lone, Nazir I, additional, Leavy, Olivia C, additional, Daines, Luke, additional, Baillie, J Kenneth, additional, Brown, Jeremy S, additional, Chalder, Trudie, additional, De Soyza, Anthony, additional, Diar Bakerly, Nawar, additional, Easom, Nicholas, additional, Geddes, John R, additional, Greening, Neil J, additional, Hart, Nick, additional, Heaney, Liam G, additional, Heller, Simon, additional, Howard, Luke, additional, Hurst, John R, additional, Jacob, Joseph, additional, Jenkins, R Gisli, additional, Jolley, Caroline, additional, Kerr, Steven, additional, Kon, Onn M, additional, Lewis, Keir, additional, Lord, Janet M, additional, McCann, Gerry P, additional, Neubauer, Stefan, additional, Openshaw, Peter J M, additional, Parekh, Dhruv, additional, Pfeffer, Paul, additional, Rahman, Najib M, additional, Raman, Betty, additional, Richardson, Matthew, additional, Rowland, Matthew, additional, Semple, Malcolm G, additional, Shah, Ajay M, additional, Singh, Sally J, additional, Sheikh, Aziz, additional, Thomas, David, additional, Toshner, Mark, additional, Chalmers, James D, additional, Ho, Ling-Pei, additional, Horsley, Alex, additional, Marks, Michael, additional, Poinasamy, Krisnah, additional, Wain, Louise V, additional, Brightling, Christopher E, additional, Abel, K, additional, Adamali, H, additional, Adeloye, D, additional, Adeyemi, O, additional, Adeyemi, F, additional, Ahmad, S, additional, Ahmed, R, additional, Ainsworth, M, additional, Alamoudi, A, additional, Aljaroof, M, additional, Allan, L, additional, Allen, R, additional, Alli, A, additional, Al-Sheklly, B, additional, Altmann, D, additional, Anderson, D, additional, Andrews, M, additional, Angyal, A, additional, Antoniades, C, additional, Arbane, G, additional, Armour, C, additional, Armstrong, N, additional, Armstrong, L, additional, Arnold, H, additional, Arnold, D, additional, Ashworth, M, additional, Ashworth, A, additional, Assefa-Kebede, H, additional, Atkin, P, additional, Atkins, H, additional, Atkins, A, additional, Aul, R, additional, Avram, C, additional, Baggott, R, additional, Baguley, D, additional, Baillie, J K, additional, Bain, S, additional, Bakali, M, additional, Bakau, M, additional, Baldry, E, additional, Baldwin, D, additional, Ballard, C, additional, Bambrough, J, additional, Barker, R E, additional, Barratt, S, additional, Barrett, F, additional, Basu, N, additional, Batterham, R, additional, Baxendale, H, additional, Bayes, H, additional, Bayley, M, additional, Beadsworth, M, additional, Beirne, P, additional, Bell, R, additional, Bell, D, additional, Berry, C, additional, Betts, S, additional, Bhui, K, additional, Bishop, L, additional, Blaikely, J, additional, Bloomfield, C, additional, Bloss, A, additional, Bolger, A, additional, Bolton, C E, additional, Bonnington, J, additional, Botkai, A, additional, Bourne, M, additional, Bourne, C, additional, Bradley, E, additional, Bramham, K, additional, Brear, L, additional, Breen, G, additional, Breeze, J, additional, Briggs, A, additional, Bright, E, additional, Brightling, C E, additional, Brill, S, additional, Brindle, K, additional, Broad, L, additional, Broome, M, additional, Brown, J S, additional, Brown, M, additional, Brown, J, additional, Brown, R, additional, Brown, V, additional, Brown, A, additional, Brugha, T, additional, Brunskill, N, additional, Buch, M, additional, Bularga, A, additional, Bullmore, E, additional, Burn, D, additional, Burns, G, additional, Busby, J, additional, Buttress, A, additional, Byrne, S, additional, Cairns, P, additional, Calder, P C, additional, Calvelo, E, additional, Card, B, additional, Carr, L, additional, Carson, G, additional, Carter, P, additional, Cavanagh, J, additional, Chalder, T, additional, Chalmers, J D, additional, Chambers, R C, additional, Channon, K, additional, Chapman, K, additional, Charalambou, A, additional, Chaudhuri, N, additional, Checkley, A, additional, Chen, J, additional, Chetham, L, additional, Chilvers, E R, additional, Chinoy, H, additional, Chong-James, K, additional, Choudhury, N, additional, Choudhury, G, additional, Chowdhury, P, additional, Chowienczyk, P, additional, Christie, C, additional, Clark, D, additional, Clark, C, additional, Clarke, J, additional, Clift, P, additional, Clohisey, S, additional, Coburn, Z, additional, Cole, J, additional, Coleman, C, additional, Connell, D, additional, Connolly, B, additional, Connor, L, additional, Cook, A, additional, Cooper, B, additional, Coupland, C, additional, Craig, T, additional, Crisp, P, additional, Cristiano, D, additional, Crooks, M G, additional, Cross, A, additional, Cruz, I, additional, Cullinan, P, additional, Daines, L, additional, Dalton, M, additional, Dark, P, additional, Dasgin, J, additional, David, A, additional, David, C, additional, Davies, M, additional, Davies, G, additional, Davies, K, additional, Davies, F, additional, Davies, G A, additional, Daynes, E, additional, De Silva, T, additional, De Soyza, A, additional, Deakin, B, additional, Deans, A, additional, Defres, S, additional, Dell, A, additional, Dempsey, K, additional, Dennis, J, additional, Dewar, A, additional, Dharmagunawardena, R, additional, Diar Bakerly, N, additional, Dipper, A, additional, Diver, S, additional, Diwanji, S N, additional, Dixon, M, additional, Djukanovic, R, additional, Dobson, H, additional, Dobson, C, additional, Dobson, S L, additional, Docherty, A B, additional, Donaldson, A, additional, Dong, T, additional, Dormand, N, additional, Dougherty, A, additional, Dowling, R, additional, Drain, S, additional, Dulawan, P, additional, Dunn, S, additional, Easom, N, additional, Echevarria, C, additional, Edwards, S, additional, Edwardson, C, additional, Elliott, B, additional, Elliott, A, additional, Ellis, Y, additional, Elmer, A, additional, Elneima, O, additional, Evans, R A, additional, Evans, J, additional, Evans, H, additional, Evans, D, additional, Evans, R I, additional, Evans, R, additional, Evans, T, additional, Fabbri, L, additional, Fairbairn, S, additional, Fairman, A, additional, Fallon, K, additional, Faluyi, D, additional, Favager, C, additional, Felton, T, additional, Finch, J, additional, Finney, S, additional, Fisher, H, additional, Fletcher, S, additional, Flockton, R, additional, Foote, D, additional, Ford, A, additional, Forton, D, additional, Francis, R, additional, Francis, S, additional, Francis, C, additional, Frankel, A, additional, Fraser, E, additional, Free, R, additional, French, N, additional, Fuld, J, additional, Furniss, J, additional, Garner, L, additional, Gautam, N, additional, Geddes, J R, additional, George, P M, additional, George, J, additional, Gibbons, M, additional, Gilmour, L, additional, Gleeson, F, additional, Glossop, J, additional, Glover, S, additional, Goodman, N, additional, Gooptu, B, additional, Gorsuch, T, additional, Gourlay, E, additional, Greenhaff, P, additional, Greenhalf, W, additional, Greenhalgh, A, additional, Greening, N J, additional, Greenwood, J, additional, Greenwood, S, additional, Gregory, R, additional, Grieve, D, additional, Gummadi, M, additional, Gupta, A, additional, Gurram, S, additional, Guthrie, E, additional, Hadley, K, additional, Haggar, A, additional, Hainey, K, additional, Haldar, P, additional, Hall, I, additional, Hall, L, additional, Halling-Brown, M, additional, Hamil, R, additional, Hanley, N A, additional, Hardwick, H, additional, Hardy, E, additional, Hargadon, B, additional, Harrington, K, additional, Harris, V, additional, Harrison, E M, additional, Harrison, P, additional, Hart, N, additional, Harvey, A, additional, Harvey, M, additional, Harvie, M, additional, Havinden-Williams, M, additional, Hawkes, J, additional, Hawkings, N, additional, Haworth, J, additional, Hayday, A, additional, Heaney, L G, additional, Heeney, J L, additional, Heightman, M, additional, Heller, S, additional, Henderson, M, additional, Hesselden, L, additional, Hillman, T, additional, Hingorani, A, additional, Hiwot, T, additional, Ho, L P, additional, Hoare, A, additional, Hoare, M, additional, Hogarth, P, additional, Holbourn, A, additional, Holdsworth, L, additional, Holgate, D, additional, Holmes, K, additional, Holroyd-Hind, B, additional, Horsley, A, additional, Hosseini, A, additional, Hotopf, M, additional, Houchen, L, additional, Howard, L, additional, Howell, A, additional, Hufton, E, additional, Hughes, A, additional, Hughes, J, additional, Hughes, R, additional, Humphries, A, additional, Huneke, N, additional, Hurst, J R, additional, Hurst, R, additional, Husain, M, additional, Hussell, T, additional, Ibrahim, W, additional, Ient, A, additional, Ingram, L, additional, Ismail, K, additional, Jackson, T, additional, Jacob, J, additional, James, W Y, additional, Janes, S, additional, Jarvis, H, additional, Jayaraman, B, additional, Jenkins, R G, additional, Jezzard, P, additional, Jiwa, K, additional, Johnson, S, additional, Johnson, C, additional, Johnston, D, additional, Jolley, C, additional, Jolley, C J, additional, Jones, I, additional, Jones, S, additional, Jones, D, additional, Jones, H, additional, Jones, G, additional, Jones, M, additional, Jose, S, additional, Kabir, T, additional, Kaltsakas, G, additional, Kamwa, V, additional, Kar, P, additional, Kausar, Z, additional, Kelly, S, additional, Kerr, S, additional, Key, A L, additional, Khan, F, additional, Khunti, K, additional, King, C, additional, King, B, additional, Kitterick, P, additional, Klenerman, P, additional, Knibbs, L, additional, Knight, S, additional, Knighton, A, additional, Kon, O M, additional, Kon, S, additional, Kon, S S, additional, Korszun, A, additional, Kotanidis, C, additional, Koychev, I, additional, Kurupati, P, additional, Kwan, J, additional, Laing, C, additional, Lamlum, H, additional, Landers, G, additional, Langenberg, C, additional, Lasserson, D, additional, Lawrie, A, additional, Lea, A, additional, Leavy, O C, additional, Lee, D, additional, Lee, E, additional, Leitch, K, additional, Lenagh, R, additional, Lewis, K, additional, Lewis, V, additional, Lewis, K E, additional, Lewis, J, additional, Lewis-Burke, N, additional, Light, T, additional, Lightstone, L, additional, Lim, L, additional, Linford, S, additional, Lingford-Hughes, A, additional, Lipman, M, additional, Liyanage, K, additional, Lloyd, A, additional, Logan, S, additional, Lomas, D, additional, Lone, N I, additional, Loosley, R, additional, Lord, J M, additional, Lota, H, additional, Lucey, A, additional, MacGowan, G, additional, Macharia, I, additional, Mackay, C, additional, Macliver, L, additional, Madathil, S, additional, Madzamba, G, additional, Magee, N, additional, Mairs, N, additional, Majeed, N, additional, Major, E, additional, Malim, M, additional, Mallison, G, additional, Man, W, additional, Mandal, S, additional, Mangion, K, additional, Mansoori, P, additional, Marciniak, S, additional, Mariveles, M, additional, Marks, M, additional, Marshall, B, additional, Martineau, A, additional, Maskell, N, additional, Matila, D, additional, Matthews, L, additional, Mayet, J, additional, McAdoo, S, additional, McAllister-Williams, H, additional, McArdle, P, additional, McArdle, A, additional, McAulay, D, additional, McAuley, H, additional, McAuley, D F, additional, McCafferty, K, additional, McCann, G P, additional, McCauley, H, additional, McCourt, P, additional, Mcgarvey, L, additional, McGinness, J, additional, McGovern, A, additional, McGuinness, H, additional, McInnes, I B, additional, McIvor, K, additional, McIvor, E, additional, McMahon, A, additional, McMahon, M J, additional, McMorrow, L, additional, Mcnally, T, additional, McNarry, M, additional, McQueen, A, additional, McShane, H, additional, Megson, S, additional, Meiring, J, additional, Menzies, D, additional, Michael, A, additional, Milligan, L, additional, Mills, N, additional, Mitchell, J, additional, Mohamed, A, additional, Molyneaux, P L, additional, Monteiro, W, additional, Morley, A, additional, Morrison, L, additional, Morriss, R, additional, Morrow, A, additional, Moss, A, additional, Moss, A J, additional, Moss, P, additional, Mukaetova-Ladinska, E, additional, Munawar, U, additional, Murali, E, additional, Murira, J, additional, Nassa, H, additional, Neill, P, additional, Neubauer, S, additional, Newby, D, additional, Newell, H, additional, Newton Cox, A, additional, Nicholson, T, additional, Nicoll, D, additional, Nolan, C M, additional, Noonan, M J, additional, Novotny, P, additional, Nunag, J, additional, Nyaboko, J, additional, O'Brien, L, additional, Odell, N, additional, Ogg, G, additional, Olaosebikan, O, additional, Oliver, C, additional, Omar, Z, additional, Openshaw, P J M, additional, Rivera-Ortega, P, additional, Osbourne, R, additional, Ostermann, M, additional, Overton, C, additional, Oxton, J, additional, Pacpaco, E, additional, Paddick, S, additional, Papineni, P, additional, Paradowski, K, additional, Pareek, M, additional, Parekh, D, additional, Parfrey, H, additional, Pariante, C, additional, Parker, S, additional, Parkes, M, additional, Parmar, J, additional, Parvin, R, additional, Patale, S, additional, Patel, B, additional, Patel, S, additional, Patel, M, additional, Pathmanathan, B, additional, Pavlides, M, additional, Pearl, J E, additional, Peckham, D, additional, Pendlebury, J, additional, Peng, Y, additional, Pennington, C, additional, Peralta, I, additional, Perkins, E, additional, Peto, T, additional, Petousi, N, additional, Petrie, J, additional, Pfeffer, P, additional, Phipps, J, additional, Pimm, J, additional, Piper Hanley, K, additional, Pius, R, additional, Plein, S, additional, Plekhanova, T, additional, Poinasamy, K, additional, Polgar, O, additional, Poll, L, additional, Porter, J C, additional, Portukhay, S, additional, Powell, N, additional, Price, L, additional, Price, D, additional, Price, A, additional, Price, C, additional, Prickett, A, additional, Quaid, S, additional, Quigley, J, additional, Quint, J, additional, Qureshi, H, additional, Rahman, N, additional, Rahman, M, additional, Ralser, M, additional, Raman, B, additional, Ramos, A, additional, Rangeley, J, additional, Rees, T, additional, Regan, K, additional, Richards, A, additional, Richardson, M, additional, Robertson, E, additional, Rodgers, J, additional, Ross, G, additional, Rossdale, J, additional, Rostron, A, additional, Routen, A, additional, Rowland, A, additional, Rowland, M J, additional, Rowland, J, additional, Rowland-Jones, S L, additional, Roy, K, additional, Rudan, I, additional, Russell, R, additional, Russell, E, additional, Sabit, R, additional, Sage, E K, additional, Samani, N, additional, Samuel, R, additional, Sapey, E, additional, Saralaya, D, additional, Saratzis, A, additional, Sargeant, J, additional, Sass, T, additional, Sattar, N, additional, Saunders, K, additional, Saunders, R, additional, Saxon, W, additional, Sayer, A, additional, Schwaeble, W, additional, Scott, J, additional, Scott, K, additional, Selby, N, additional, Semple, M G, additional, Sereno, M, additional, Shah, K, additional, Shah, A, additional, Shah, P, additional, Sharma, M, additional, Sharpe, M, additional, Sharpe, C, additional, Shaw, V, additional, Sheikh, A, additional, Shevket, K, additional, Shikotra, A, additional, Short, J, additional, Siddiqui, S, additional, Sigfrid, L, additional, Simons, G, additional, Simpson, J, additional, Singapuri, A, additional, Singh, S J, additional, Singh, C, additional, Singh, S, additional, Skeemer, J, additional, Smith, I, additional, Smith, J, additional, Smith, L, additional, Smith, A, additional, Soares, M, additional, Southern, D, additional, Spears, M, additional, Spencer, L G, additional, Speranza, F, additional, Stadon, L, additional, Stanel, S, additional, Steiner, M, additional, Stensel, D, additional, Stern, M, additional, Stewart, I, additional, Stockley, J, additional, Stone, R, additional, Storrie, A, additional, Storton, K, additional, Stringer, E, additional, Subbe, C, additional, Sudlow, C, additional, Suleiman, Z, additional, Summers, C, additional, Summersgill, C, additional, Sutherland, D, additional, Sykes, D L, additional, Sykes, R, additional, Talbot, N, additional, Tan, A L, additional, Taylor, C, additional, Taylor, A, additional, Te, A, additional, Tedd, H, additional, Tee, C J, additional, Tench, H, additional, Terry, S, additional, Thackray-Nocera, S, additional, Thaivalappil, F, additional, Thickett, D, additional, Thomas, D, additional, Thomas, D C, additional, Thomas, A K, additional, Thompson, A A R, additional, Thompson, T, additional, Thornton, T, additional, Thwaites, R S, additional, Tobin, M, additional, Toingson, G F, additional, Tong, C, additional, Toshner, M, additional, Touyz, R, additional, Tripp, K A, additional, Tunnicliffe, E, additional, Turner, E, additional, Turtle, L, additional, Turton, H, additional, Ugwuoke, R, additional, Upthegrove, R, additional, Valabhji, J, additional, Vellore, K, additional, Wade, E, additional, Wain, L V, additional, Wajero, L O, additional, Walder, S, additional, Walker, S, additional, Wall, E, additional, Wallis, T, additional, Walmsley, S, additional, Walsh, S, additional, Walsh, J A, additional, Watson, L, additional, Watson, J, additional, Watson, E, additional, Welch, C, additional, Welch, H, additional, Welsh, B, additional, Wessely, S, additional, West, S, additional, Wheeler, H, additional, Whitehead, V, additional, Whitney, J, additional, Whittaker, S, additional, Whittam, B, additional, Wild, J, additional, Wilkins, M, additional, Wilkinson, D, additional, Williams, N, additional, Williams, B, additional, Williams, J, additional, Williams-Howard, S A, additional, Willicombe, M, additional, Willis, G, additional, Wilson, D, additional, Wilson, I, additional, Window, N, additional, Witham, M, additional, Wolf-Roberts, R, additional, Woodhead, F, additional, Woods, J, additional, Wootton, D, additional, Worsley, J, additional, Wraith, D, additional, Wright, L, additional, Wright, C, additional, Wright, S, additional, Xie, C, additional, Yasmin, S, additional, Yates, T, additional, Yip, K P, additional, Young, B, additional, Young, S, additional, Young, A, additional, Yousuf, A J, additional, Yousuf, A, additional, Zawia, A, additional, Zhao, B, additional, and Zongo, O, additional

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2021
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19. Short Notices

Author

Bennett, Joan, Batho, E. C., Husbands, Winifred, Jackson, Kenneth, Entwistle, William J., Clark, James M., and Atkins, H. G.

Published
1940

20. Short Notices

Author

Solomon, L., Macdonald, A., Sisson, C. J., Davis, B. E. C., Tillotson, Geoffrey, Bennett, Joan, Kitchen, George, Thomas, W. D., Pyle, Fitzroy, Atkinson, William C., McClean, R. J., Willoughby, L. A., and Atkins, H. G.

Published
1940

21. Short Notices

Author

Pattison, Bruce, Waldock, A. J. A., Tillotson, G., Husbands, H. Winifred, Kitchin, G., Macdonald, Angus, Entwistle, W. J., Silver, M., Tancock, L. W., Moore, Mina J., Collinson, W. E., Wardale, W. L., Houston, G. Craig, Gillies, A., and Atkins, H. G.

Published
1939

22. Short Notices

Author

Potter, Simeon, Wilson, R. M., Bullough, G., Crofts, J., Bennett, Joan, Sisson, Edward O., Sutherland, J. R., Orr, J., Tancock, L. W., Briggs, E. R., Carr, Charles T., and Atkins, H. G.

Published
1939

23. Short Notices

Author

Macdonald, Angus, Walter, J. H., Tillotson, G., Sisson, C. J., Miller, W. W., Hunt, H. J., Foligno, C., Entwistle, William J., Amburger-Stuart, H. S. M., Massey, I. M., and Atkins, H. G.

Published
1937

24. Short Notices

Author

Wilson, R. M., Tillotson, G., Roberts, S. C., Batho, Edith C., Budd, F. E., Elcock, W. D., Moore, W. G., Entwistle, William J., Turquet-Milnes, Gladys, Dillon, M., Coveney, D. K., Amburger-Stuart, H. S. M., Collinson, W. E., Closs, August, and Atkins, H. G.

Published
1938

25. Short Notices

Author

Husbands, H. Winifred, Kitchin, George, Budd, F. E., Roberts, S. C., Elton, O., Dechamps, J., Moore, W. G., Turquet-Milnes, Gladys, Foligno, C., Parker, A. A., Entwistle, William J., Collinson, W. E., Dunstan, A. C., Pickering, F. P., Clark, James M., Peacock, R., Closs, August, and Atkins, H. G.

Published
1938

26. Short Notices

Author

Hulme, Hilda M., Blackman, E., Williams, Harold, Roberts, S. C., Husbands, H. Winifred, Legge, M. Dominica, Walton, Thomas, Legge, J. G., Entwistle, W. J., Amburger-Stuart, H. S. M., Closs, A., Atkins, H. G., and Norman, F.

Published
1936

31. Disruption of the surfactant protein A receptor SP-R210L (CD245α/MYO18Aα) alters respiratory function and iron sequestration in alveolar macrophages of aged mice

Author

Abdulqadir R, Guan Z, Halstead Es, Bingaman Ss, Hassan K, Atkins H, Zissis C. Chroneos, Susan L. DiAngelo, Arnold Ac, E. Yau, Timothy K. Cooper, Todd M. Umstead, Hu S, and Fino K

Subjects
Gene isoform, education.field_of_study, Chemistry, Population, Alveolar macrophage, Macrophage, Collectin, Respiratory function, education, Receptor, Surfactant protein A, Cell biology
Abstract

Previous studies demonstrated that the host defense collectins, surfactant protein A and complement component 1q, modulate tissue-dependent macrophage activation, pathogen clearance, and regulatory macrophage functions through the receptor SP-R210, which consists of two isoforms SP-R210L and SP-R210S. These isoforms are encoded by alternatively spliced mRNAs of the Myo18a MYO18A gene in mice and humans. The present study in conditional transgenic mice revealed novel age-related functions of the SP-R210L isoform in modulating pulmonary mechanics, iron sequestration in alveolar macrophages (AMs), and life-long maintenance of the alveolar macrophage population. Our findings support the novel idea that SP-R210L-deficient AMs undergo bi-directional epigenetic adaptation that results in chronic dysregulation of broncho-alveolar function, immune homeostasis, and maintenance of oncotic balance at the airway-capillary interface. Disruption of SP-R210L increases the risk for development of severe interstitial lung disease during development and aging.

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2021
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38. bortezomib&ndash

Author

Figueiredo, A., Atkins, H., Mallick, R., Kekre, N., Kew, A., and McCurdy, A.

Subjects
bortezomib, toxicity, Myeloma, CyBorD
Abstract

Cyclophosphamide&ndash, bortezomib&ndash, dexamethasone (CyBorD) is considered a standard induction regimen for transplant-eligible patients with newly diagnosed multiple myeloma (mm). It has not been prospectively compared with bortezomib&ndash, dexamethasone (Bor-Dex). We aimed to compare the efficacy of CyBorD and Bor-Dex induction in transplant-eligible patients. In a retrospective observational study at a single tertiary centre, all patients with transplant-eligible mm who received induction with CyBorD or Bor-Dex between March 2008 and April 2016 were enrolled. Progression-free survival (pfs), response, and stem-cell collection for a first autologous stem-cell transplantation (ahsct) were compared. Of 155 patients enrolled, 78 (50.3%) had received CyBorD, and 77 (49.7%), Bor-Dex. The patients in the Bor-Dex cohort were younger than those in the CyBorD cohort (median: 57 years vs. 62 years, p = 0.0002) and more likely to have had treatment held, reduced, or discontinued (26% vs. 14.5%, p = 0.11). The stem-cell mobilization regimen for both cohorts was predominantly cyclophosphamide and granulocyte colony&ndash, stimulating factor (gcsf). Plerixafor was used more often for the CyBorD cohort (p = 0.009), and more collection failures occurred in the CyBorD cohort (p = 0.08). In patients receiving Bor-Dex, more cells were collected (9.9&times, 106 cells/kg vs. 7.7&times, 106cells/kg, p = 0.007). At day +100, a very good partial response or better was achieved in 75% of the CyBorD cohort and in 73% of the Bor-Dex cohort (p = 0.77). Median pfs was 3.2 years in the Bor-Dex cohort and 3.7 years in the CyBorD cohort (p = 0.56). Overall efficacy was similar in our patients receiving CyBorD and Bor-Dex. After ahsct, no difference in depth of response or pfs was observed. Cyclophosphamide&ndash, gcsf seems to increase collection failures and hospitalizations in patients receiving CyBorD. Prospective studies are required to examine that relationship.

Published
2020
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39. Autologous haematopoietic stem cell transplantation as a first-line disease-modifying therapy in patients with 'aggressive' multiple sclerosis

Author

Das, J., Snowden, J. A., Burman, Joachim, Freedman, M. S., Atkins, H., Bowman, M., Burt, R. K., Saccardi, R., Innocenti, C., Mistry, S., Laud, P. J., Jessop, H., Sharrack, B., Das, J., Snowden, J. A., Burman, Joachim, Freedman, M. S., Atkins, H., Bowman, M., Burt, R. K., Saccardi, R., Innocenti, C., Mistry, S., Laud, P. J., Jessop, H., and Sharrack, B.

Abstract

Background: Autologous haematopoietic stem cell transplantation (AHSCT) is an effective treatment for patients with multiple sclerosis (MS) who have highly active disease, despite the use of standard disease-modifying therapies (DMTs). However, the optimal time for offering AHSCT to patients with ‘aggressive’ MS is yet to be established. Objectives: The objective was to explore the safety and efficacy of AHSCT as a first-line DMT in patients with ‘aggressive’ MS. Methods: All patients with ‘aggressive’ MS who received AHSCT as a first-line DMT in five European and North American centres were retrospectively evaluated. Results: Twenty patients were identified. The median interval between diagnosis and AHSCT was 5 (1–20) months. All had multiple poor prognostic markers with a median pre-transplant Expanded Disability Status Scale (EDSS) score of 5.0 (1.5–9.5). After a median follow-up of 30 (12–118) months, the median EDSS score improved to 2.0 (0–6.5, p < 0.0001). No patient had further relapses. Three had residual magnetic resonance imaging (MRI) disease activities in the first 6 months post-transplant, but no further new or enhancing lesions were observed in subsequent scans. Conclusion: AHSCT is safe and effective as a first-line DMT in inducing rapid and sustained remission in patients with ‘aggressive’ MS.

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2021
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46. Autologous haematopoietic stem cell transplantation as a first-line disease-modifying therapy in patients with ‘aggressive’ multiple sclerosis

Author

Das, J, primary, Snowden, JA, additional, Burman, J, additional, Freedman, MS, additional, Atkins, H, additional, Bowman, M, additional, Burt, RK, additional, Saccardi, R, additional, Innocenti, C, additional, Mistry, S, additional, Laud, PJ, additional, Jessop, H, additional, and Sharrack, B, additional

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2021
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48. Dexamethasone therapy in COVID‐19 patients: implications and guidance for the management of blood glucose in people with and without diabetes

Author

Rayman, G., primary, Lumb, A. N., additional, Kennon, B., additional, Cottrell, C., additional, Nagi, D., additional, Page, E., additional, Voigt, D., additional, Courtney, H. C., additional, Atkins, H., additional, Higgins, K., additional, Platts, J., additional, Dhatariya, K., additional, Patel, M., additional, Newland‐Jones, P., additional, Narendran, P., additional, Kar, P., additional, Burr, O., additional, Thomas, S., additional, and Stewart, R., additional

Published
2020
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49. New Guidance on Managing Inpatient Hyperglycaemia during the COVID‐19 Pandemic

Author

Rayman, G., primary, Lumb, A., additional, Kennon, B., additional, Cottrell, C., additional, Nagi, D., additional, Page, E., additional, Voigt, D., additional, Courtney, H., additional, Atkins, H., additional, Platts, J., additional, Higgins, K., additional, Dhatariya, K., additional, Patel, M., additional, Narendran, P., additional, Kar, P., additional, Newland‐Jones, P., additional, Stewart, R., additional, Burr, O., additional, and Thomas, S., additional

Published
2020
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50. Guidance on the management of Diabetic Ketoacidosis in the exceptional circumstances of the COVID‐19 pandemic

Author

Rayman, G., primary, Lumb, A., additional, Kennon, B., additional, Cottrell, C., additional, Nagi, D., additional, Page, E., additional, Voigt, D., additional, Courtney, H., additional, Atkins, H., additional, Platts, J., additional, Higgins, K., additional, Dhatariya, K., additional, Patel, M., additional, Narendran, P., additional, Kar, P., additional, Newland‐Jones, P., additional, Stewart, R., additional, Burr, O., additional, and Thomas, S., additional

Published
2020
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