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2. Non-Pharmacological Treatments

Author

Barbini, B., Seghi, F., Bosia, M., Fregna, L., Martini, F., Attanasio, F., Manfredi, E., Vassena, G., Colombo, C., Cavallaro, R., Cavallaro, Roberto, editor, and Colombo, Cristina, editor

Published
2022
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3. Psychopharmacology

Author

Zanardi, R., Spangaro, M., Attanasio, F., Sapienza, J., Martini, F., Fregna, L., Cavallaro, R., Colombo, C., Cavallaro, Roberto, editor, and Colombo, Cristina, editor

Published
2022
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4. Monitoring medicine prescriptions before, during and after pregnancy in Italy

Author

Fortinguerra, F, Belleudi, V, Poggi, F, Perna, S, Bortolus, R, Donati, S, D'Aloja, P, Da Cas, R, Clavenna, A, Locatelli, A, Addis, A, Davoli, M, Trotta, F, Rezza, G, Lombardozzi, L, Fortino, I, Mazzone, A, Schiatti, S, Zanforlini, M, Deambrosis, P, Manea, S, Salmaso, L, Scroccaro, G, Marata, A, Puccini, A, Solfrini, V, Attanasio, F, Gini, R, De Giorgi, M, Fran-Chini, D, Rossi, M, Stella, V, Carta, P, Garau, D, Ledda, S, Serra, E, Fortinguerra F., Belleudi V., Poggi F. R., Perna S., Bortolus R., Donati S., D'Aloja P., Da Cas R., Clavenna A., Locatelli A., Addis A., Davoli M., Trotta F., Rezza G., Lombardozzi L., Fortino I., Mazzone A., Schiatti S., Zanforlini M., Deambrosis P., Manea S., Salmaso L., Scroccaro G., Marata A. M., Puccini A., Solfrini V., Attanasio F., Gini R., De Giorgi M., Fran-Chini D., Rossi M., Stella V. M. P., Carta P., Garau D., Ledda S., Serra E., Fortinguerra, F, Belleudi, V, Poggi, F, Perna, S, Bortolus, R, Donati, S, D'Aloja, P, Da Cas, R, Clavenna, A, Locatelli, A, Addis, A, Davoli, M, Trotta, F, Rezza, G, Lombardozzi, L, Fortino, I, Mazzone, A, Schiatti, S, Zanforlini, M, Deambrosis, P, Manea, S, Salmaso, L, Scroccaro, G, Marata, A, Puccini, A, Solfrini, V, Attanasio, F, Gini, R, De Giorgi, M, Fran-Chini, D, Rossi, M, Stella, V, Carta, P, Garau, D, Ledda, S, Serra, E, Fortinguerra F., Belleudi V., Poggi F. R., Perna S., Bortolus R., Donati S., D'Aloja P., Da Cas R., Clavenna A., Locatelli A., Addis A., Davoli M., Trotta F., Rezza G., Lombardozzi L., Fortino I., Mazzone A., Schiatti S., Zanforlini M., Deambrosis P., Manea S., Salmaso L., Scroccaro G., Marata A. M., Puccini A., Solfrini V., Attanasio F., Gini R., De Giorgi M., Fran-Chini D., Rossi M., Stella V. M. P., Carta P., Garau D., Ledda S., and Serra E.

Abstract

Background The use of medications during pregnancy is a common event worldwide. Monitoring medicine prescriptions in clinical practice is a necessary step in assessing the impact of therapeutic choices in pregnant women as well as the adherence to clinical guidelines. The aim of this study was to provide prevalence data on medication use before, during and after pregnancy in the Italian population. Methods A retrospective prevalence study using administrative healthcare databases was conducted. A cohort of 449,012 pregnant women (15-49 years) residing in eight Italian regions (59% of national population), who delivered in 2016-2018, were enrolled. The prevalence of medication use was estimated as the proportion (%) of pregnant women with any prescription. Results About 73.1% of enrolled women received at least one drug prescription during pregnancy, 57.1% in pre-pregnancy and 59.3% in postpartum period. The prevalence of drug prescriptions increased with maternal age, especially during the 1st trimester of pregnancy. The most prescribed medicine was folic acid (34.6%), followed by progesterone (19%), both concentrated in 1st trimester of pregnancy (29.2% and 14.8%, respectively). Eight of the top 30 most prescribed medications were antibiotics, whose prevalence was higher during 2nd trimester of pregnancy in women ≥ 40 years (21.6%). An increase in prescriptions of antihypertensives, antidiabetics, thyroid hormone and heparin preparations was observed during pregnancy; on the contrary, a decrease was found for chronic therapies, such as antiepileptics or lipid-modifying agents. Conclusions This study represents the largest and most representative population-based study illustrating the medication prescription patterns before, during and after pregnancy in Italy. The observed prescriptive trends were comparable to those reported in other European countries. Given the limited information on medication use in Italian pregnant women, the performed analyses provide an up

Published
2023

6. Predicting unipolar and bipolar depression using inflammatory markers, neuroimaging and neuropsychological data: a machine learning study

Author

Raffaelli, L., primary, Colombo, F., additional, Calesella, F., additional, Fortaner-Uya, L., additional, Bollettini, I., additional, Lorenzi, C., additional, Maggioni, E., additional, Tassi, E., additional, Poletti, S., additional, Zanardi, R., additional, Attanasio, F., additional, Benedetti, F., additional, and Vai, B., additional

Published
2023
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7. HTA187 Best Practices for the Development of Budget Impact Models at Regional Level

Author

Marcellusi, A, primary, Ragonese, A, additional, Bortolami, A, additional, Marinozzi, A, additional, Mucherino, S, additional, Moreno, C, additional, Antenori, A, additional, Attanasio, F, additional, Cicoira, M, additional, Donati, C, additional, Ferrario, M, additional, Lasala, R, additional, Roni, C, additional, Russoniello, F, additional, Simonelli, C, additional, Zanuzzi, M, additional, and Canonico, PL, additional

Published
2022
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11. Semax, a Synthetic Regulatory Peptide, Affects Copper-Induced Abeta Aggregation and Amyloid Formation in Artificial Membrane Models

Author

Sciacca M.F.M., Naletova I., Giuffrida M.L., and Attanasio F.

Subjects
inorganic chemicals, copper, Alzheimer, peptides, aggregation, oligomers, amyloid ?
Abstract

Alzheimer's disease, the most common form of dementia, is characterized by the aggregation of amyloid beta protein (A?). The aggregation and toxicity of A? are strongly modulated by metal ions and phospholipidic membranes. In particular, Cu2+ ions play a pivotal role in modulating A? aggregation. Although in the last decades several natural or synthetic compounds were evaluated as candidate drugs, to date, no treatments are available for the pathology. Multifunctional compounds able to both inhibit fibrillogenesis, and in particular the formation of oligomeric species, and prevent the formation of the A?:Cu2+ complex are of particular interest. Here we tested the anti-aggregating properties of a heptapeptide, Semax, an ACTH-like peptide, which is known to form a stable complex with Cu2+ ions and has been proven to have neuroprotective and nootropic effects. We demonstrated through a combination of spectrofluorometric, calorimetric, and MTT assays that Semax not only is able to prevent the formation of A?:Cu2+ complexes but also has anti-aggregating and protective properties especially in the presence of Cu2+. The results suggest that Semax inhibits fiber formation by interfering with the fibrillogenesis of A?:Cu2+ complexes.

Published
2022
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18. Thermodynamics of spin-orbit-coupled bosons in two dimensions from the complex Langevin method

Author

Attanasio, F. and Drut, J.E.

Abstract

We investigate the thermal properties of interacting spin-orbit-coupled bosons with contact interactions in two spatial dimensions. To that end, we implement the complex Langevin method, motivated by the appearance of a sign problem, on a square lattice with periodic boundary conditions. We calculate the density equation of state nonperturbatively in a range of spin-orbit couplings and chemical potentials. Our results show that mean-field solutions tend to underestimate the average density, especially for stronger values of the spin-orbit coupling. Additionally, the finite nature of the simulation volume induces the formation of pseudocondensates. These have been observed to be destroyed by the spin-orbit interactions.

Published
2020
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27. Corrigendum to: : Ac-LPFFD-Th: A Trehalose-Conjugated Peptidomimetic as a Strong Suppressor of Amyloid-? Oligomer Formation and Cytotoxicity (ChemBioChem, (2016), 17, (1541-1549), 10.1002/cbic.201600243)

Author

Sinopoli A., Giuffrida A., Tomasello M.F., Giuffrida M.L., Leone M., Attanasio F., Caraci F., De Bona P., Naletova I., Saviano M., Copani A., Pappalardo G., and Rizzarelli E.

Subjects
Amyloid-?
Abstract

The stereochemistry of threalose given in the Table of Contents and in Scheme 1 was incorrect; the correct structure is shown below. We would like to thank Dr. Sébastien Vidal (Université Lyon 1) for drawing our attention to this matter. (Figure presented.).

Published
2016
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28. Designing trehalose-conjugated peptides for the inhibition of Alzheimer’s Aβ oligomerization and neurotoxicity

Author

DE BONA P, GIUFFRIDA M. L, ATTANASIO F, COPANI A, PIGNATARO, Bruno Giuseppe, CATALDO, Sebastiano, RIZZARELLI E, PAPPALARDO G., Pappalardo, G., De Bona, P., Giuffrida, M., Attanasio, F., Copani, A., Pignataro, B., Cataldo, S., Rizzarelli, E., DE BONA P, GIUFFRIDA M L, ATTANASIO F, COPANI A, PIGNATARO B, CATALDO S, RIZZARELLI E, and PAPPALARDO G

Subjects
Neurotoxicity, Alzheimer, Amyloids, beta-sheet breaker peptides • amyloid-beta • trehalose • SFM • neuronal cultures • thioflavin T
Published
2008

32. SENSING OF AMYLOID AGGREGATION USING A NOVEL BIS-THIOPHENE FLUORESCENT DYE

Author

Bonaccorso, C, Attanasio, F, Bellia, F, Fortuna, G, Musumarra, G, Rizzarelli, E., CATALDO, Sebastiano, PIGNATARO, Bruno Giuseppe, Bonaccorso, C, Attanasio, F, Bellia, F, Cataldo, S, Fortuna, G, Pignataro, BG, Musumarra, G, and Rizzarelli, E

Subjects
neurodegenerative disease, amyloid aggregation, fluorescent probe, Alzheimer's disease
Published
2012

33. Copper(II) and zinc(II) interaction with abeta42: effects of metal binding on peptide's aggregation rate and morphology of the aggregates

Author

Pappalardo, G, De Bona, P, Milardi, D, Attanasio, F, Sciacca, MFM, Rizzarelli, E., CATALDO, Sebastiano, PIGNATARO, Bruno Giuseppe, Pappalardo, G, De Bona, P, Milardi, D, Attanasio, F, Sciacca, MFM, Cataldo, S, Pignataro, B, and Rizzarelli, E

Subjects
amyloid aggregation, neurodegenerative disease, alzheimer's disease, protein self-organization
Published
2011

39. Biological activities of ß-amyloid monomers

Author

Giuffrida, Ml, Tomasello, Fm, Caraci, Filippo, Pandini, G, Pappalardo, G, Attanasio, F, Chiechio, S, Vigneri, R, Rizzarelli, E, Nicoletti, F, and Copani, A.

Published
2013

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