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2. Orbiviruses

Author

Maan, Sushila, Belaganahalli, Manjunatha N., Maan, Narender S., Attoui, Houssam, Mertens, Peter P. C., Malik, Yashpal Singh, Series Editor, Singh, Rameshwar, Editorial Board Member, Gehlot, A. K., Editorial Board Member, Raj, G. Dhinakar, Editorial Board Member, Bujarbaruah, K. M., Editorial Board Member, Goyal, Sagar M., Editorial Board Member, Tikoo, Suresh K., Editorial Board Member, Singh, Raj Kumar, editor, and Yadav, Mahendra Pal, editor

Published
2020
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7. Orbiviruses

Author

Maan, Sushila, primary, Belaganahalli, Manjunatha N., additional, Maan, Narender S., additional, Attoui, Houssam, additional, and Mertens, Peter P. C., additional

Published
2020
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10. Age- and Sex-Associated Pathogenesis of Cell Culture-Passaged Kemerovo Virus in IFNAR (−/−) Mice.

Author

Migné, Camille Victoire, Heckmann, Aurélie, Monsion, Baptiste, Mohd Jaafar, Fauziah, Galon, Clémence, Rakotobe, Sabine, Bell-Sakyi, Lesley, Moutailler, Sara, and Attoui, Houssam

Subjects
RNA replicase, INTERFERON receptors, OPIOID receptors, AMINO acid sequence, AGE differences, MICE
Abstract

Kemerovo virus (KEMV) is a tick-borne orbivirus transmitted by ticks of the genus Ixodes. Previous animal experimentation studies with orbiviruses, in particular the interferon receptor double knock-out (IFNAR(−/−)) mouse model, did not indicate bias that is related to age or sex. We endeavoured to assess the effect of serial and alternated passages of KEMV in mammalian or Ixodes cells on virus replication and potential virulence in male or female IFNAR(−/−) mice, with important age differences: younger males (4–5 months old), older males (14–15 months old), and old females (14–15 months old). After 30 serial passages in mammalian or tick cells, or alternated passages in the two cell types, older female mice which were inoculated with the resulting virus strains were the first to show clinical signs and die. Younger males behaved differently from older males whether they were inoculated with the parental strain of KEMV or with any of the cell culture-passaged strains. The groups of male and female mice inoculated with the mammalian cell culture-adapted KEMV showed the lowest viraemia. While older female and younger male mice died by day 6 post-inoculation, surprisingly, the older males survived until the end of the experiment, which lasted 10 days. RNA extracted from blood and organs of the various mice was tested by probe-based KEMV real-time RT-PCR. Ct values of the RNA extracts were comparable between older females and younger males, while the values for older males were >5 Ct units higher for the various organs, indicating lower levels of replication. It is noteworthy that the hearts of the old males were the only organs that were negative for KEMV RNA. These results suggest, for the first time, an intriguing age- and sex-related bias for an orbivirus in this animal model. Changes in the amino acid sequence of the RNA-dependent RNA polymerase of Kemerovo virus, derived from the first serial passage in Ixodes cells (KEMV Ps.IRE1), were identified in the vicinity of the active polymerase site. This finding suggests that selection of a subpopulation of KEMV with better replication fitness in tick cells occurred. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Increased Clinical Signs and Mortality in IFNAR(−/−) Mice Immunised with the Bluetongue Virus Outer-Capsid Proteins VP2 or VP5, after Challenge with an Attenuated Heterologous Serotype

Author

Attoui, Houssam, primary, Mohd Jaafar, Fauziah, additional, Monsion, Baptiste, additional, Klonjkowski, Bernard, additional, Reid, Elizabeth, additional, Fay, Petra C., additional, Saunders, Keith, additional, Lomonossoff, George, additional, Haig, David, additional, and Mertens, Peter P. C., additional

Published
2023
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18. ICTV Virus Taxonomy Profile: Spinareoviridae 2022

Author

Matthijnssens, Jelle, Attoui, Houssam, Bányai, Krisztián, Brussaard, Corina PD, Danthi, Pranav, Del Vas, Mariana, Dermody, Terence S, Duncan, Roy, Fāng, Qín, Johne, Reimar, Mertens, Peter PC, Mohd Jaafar, Fauziah, Patton, John T, Sasaya, Takahide, Suzuki, Nobuhiro, and Wei, Taiyun

Subjects
Reovirales, taxonomy, Virology, Fungi, Spinareoviridae, Animals, Humans, Plants, ICTV report, Host Specificity, Phylogeny, RNA, Double-Stranded
Abstract

Spinareoviridae is a large family of icosahedral viruses that are usually regarded as non-enveloped with segmented (9–12 linear segments) dsRNA genomes of 23–29 kbp. Spinareovirids have a broad host range, infecting animals, fungi and plants. Some have important pathogenic potential for humans (e.g. Colorado tick fever virus), livestock (e.g. avian orthoreoviruses), fish (e.g. aquareoviruses) and plants (e.g. rice ragged stunt virus and rice black streaked dwarf virus). This is a summary of the ICTV Report on the family Spinareoviridae, which is available at ictv.global/report/spinareoviridae.

Published
2022
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20. Bluetongue Virus: From BTV-1 to BTV-27

Author

Belbis, Guillaume, primary, Zientara, Stéphan, additional, Bréard, Emmanuel, additional, Sailleau, Corinne, additional, Caignard, Grégory, additional, Vitour, Damien, additional, and Attoui, Houssam, additional

Published
2017
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21. Seadornavirus : Reoviridae

Author

Attoui, Houssam, de Lamballerie, Xavier, Tidona, Christian A., editor, Darai, Gholamreza, editor, and Büchen-Osmond, Cornelia, editor

Published
2001
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22. Coltivirus : Reoviridae

Author

de Lamballerie, Xavier, Attoui, Houssam, Tidona, Christian A., editor, Darai, Gholamreza, editor, and Büchen-Osmond, Cornelia, editor

Published
2001
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23. Increased Clinical Signs and Mortality in IFNAR (−/−) Mice Immunised with the Bluetongue Virus Outer-Capsid Proteins VP2 or VP5, after Challenge with an Attenuated Heterologous Serotype.

Author

Attoui, Houssam, Mohd Jaafar, Fauziah, Monsion, Baptiste, Klonjkowski, Bernard, Reid, Elizabeth, Fay, Petra C., Saunders, Keith, Lomonossoff, George, Haig, David, and Mertens, Peter P. C.

Subjects
BLUETONGUE virus, VIRAL proteins, SYMPTOMS, CERATOPOGONIDAE, MICE
Abstract

Bluetongue is an economically important disease of domesticated and wild ruminants caused by bluetongue virus (BTV). There are at least 36 different serotypes of BTV (the identity of which is determined by its outer-capsid protein VP2), most of which are transmitted by Culicoides biting midges. IFNAR(−/−) mice immunised with plant-expressed outer-capsid protein VP2 (rVP2) of BTV serotypes -1, -4 or -8, or the smaller outer-capsid protein rVP5 of BTV-10, or mock-immunised with PBS, were subsequently challenged with virulent strains of BTV-4 or BTV-8, or with an attenuated clone of BTV-1 (BTV-1RGC7). The mice that had received rVP2 generated a protective immune response against the homologous BTV serotype, reducing viraemia (as detected by qRT-PCR), the severity of clinical signs and mortality levels. No cross-serotype protection was observed after challenge with the heterologous BTV serotypes. However, the severity of clinical signs, viraemia and fatality levels after challenge with the attenuated strain of BTV-1 were all increased in mice immunised with rVP2 of BTV-4 and BTV-8, or with rVP5 of BTV10. The possibility is discussed that non-neutralising antibodies, reflecting serological relationships between the outer-capsid proteins of these different BTV serotypes, could lead to 'antibody-dependent enhancement of infection' (ADE). Such interactions could affect the epidemiology and emergence of different BTV strains in the field and would therefore be relevant to the design and implementation of vaccination campaigns. [ABSTRACT FROM AUTHOR]

Published
2023
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25. Mise en place de modèle d’infection des tiques en laboratoire et compétence vectorielle des tiques Ixodes pour le virus Kemerovo

Author

Migné, Camille Victoire, Hönig, Vaclav, Bonnet, Sarah I, Palus, Martin, Rakotobe, Sabine, Galon, Clémence, Heckmann, Aurélie, Seixas, Hélène Braga De, Vyletova, Eva, Devillers, Elodie, Jaafar, Fauziah Mohd, Monsion, Baptiste, Attoui, Houssam, Ruzek, Daniel, Moutailler, Sara, and Moutailler, Sara

Subjects
[SDV] Life Sciences [q-bio], ticks
Published
2022

26. Identification of the Genome Segments of Bluetongue Virus Type 26/Type 1 Reassortants Influencing Horizontal Transmission in a Mouse Model

Author

Attoui, Houssam, Monsion, Baptiste, Klonjkowski, Bernard, Zientara, Stéphan, Mertens, Peter, Mohd Jaafar, Fauziah, Virologie UMR1161 (VIRO), École nationale vétérinaire d'Alfort (ENVA)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), École nationale vétérinaire - Alfort (ENVA)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of Nottingham, UK (UON), and European Project: 727393,H2020,H2020-EU.3.2.1.1.,PALE-Blu(2017)

Subjects
BTV-1, BTV-26, Receptor, Interferon alpha-beta, MESH: Disease Transmission, Infectious, Ceratopogonidae, Serogroup, Microbiology, MESH: Bluetongue virus, Article, Mice, IFNAR(−/−) mice, bluetongue virus, Disease Transmission, Infectious, Animals, MESH: Bluetongue, bluetongue, Mice, Knockout, vector independent transmission, horizontal transmission, QR1-502, MESH: Ceratopogonidae, Disease Models, Animal, MESH: Reassortant Viruses, IFNAR (−/−) mice, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, reassortment, Genetic Engineering, Reassortant Viruses, BTV
Abstract

Bluetongue virus serotypes 1 to 24 are transmitted primarily by infected Culicoides midges, in which they also replicate. However, “atypical” BTV serotypes (BTV-25, -26, -27 and -28) have recently been identified that do not infect and replicate in adult Culicoides, or a Culicoides derived cell line (KC cells). These atypical viruses are transmitted horizontally by direct contact between infected and susceptible hosts (primarily small ruminants) causing only mild clinical signs, although the exact transmission mechanisms involved have yet to be determined. We used reverse genetics to generate a strain of BTV-1 (BTV-1 RGC7) which is less virulent, infecting IFNAR(−/−) mice without killing them. Reassortant viruses were also engineered, using the BTV-1 RGC7 genetic backbone, containing individual genome segments derived from BTV-26. These reassortant viruses were used to explore the genetic control of horizontal transmission (HT) in the IFNAR(−/−) mouse model. Previous studies showed that genome segments 1, 2 and 3 restrict infection of Culicoides cells, along with a minor role for segment 7. The current study demonstrates that genome segments 2, 5 and 10 of BTV-26 (coding for proteins VP2, NS1 and NS3/NS3a/NS5, respectively) are individually sufficient to promote HT.

Published
2021
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27. Inhibition of Orbivirus Replication by Fluvastatin and Identification of the Key Elements of the Mevalonate Pathway Involved

Author

Mohd Jaafar, Fauziah, Monsion, Baptiste, Belhouchet, Mourad, Mertens, Peter, Attoui, Houssam, Virologie UMR1161 (VIRO), École nationale vétérinaire d'Alfort (ENVA)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of Oxford [Oxford], and University of Nottingham, UK (UON)

Subjects
Inhibition of Orbivirus Replication by Fluvastatin and bluetongue virus, [SDV]Life Sciences [q-bio], viruses, fluvastatin, Mevalonic Acid, Receptor, Interferon alpha-beta, Ceratopogonidae, Virus Replication, Antiviral Agents, Bluetongue, Microbiology, Article, Cell Line, orbivirus, Mice, IFNAR(−/−) mice, bluetongue virus, HMG-CoA reductase, Virology, Animals, Humans, ComputingMilieux_MISCELLANEOUS, Viral Load, antiviral, QR1-502, Infectious Diseases, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, IFNAR (−/−) mice, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Hydroxymethylglutaryl CoA Reductases, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Yellow fever virus, Metabolic Networks and Pathways, BTV
Abstract

Statin derivatives can inhibit the replication of a range of viruses, including hepatitis C virus (HCV, Hepacivirus), dengue virus (Flavivirus), African swine fever virus (Asfarviridae) and poliovirus (Picornaviridae). We assess the antiviral effect of fluvastatin in cells infected with orbiviruses (bluetongue virus (BTV) and Great Island virus (GIV)). The synthesis of orbivirus outer-capsid protein VP2 (detected by confocal immunofluorescence imaging) was used to assess levels of virus replication, showing a reduction in fluvastatin-treated cells. A reduction in virus titres of ~1.7 log (98%) in fluvastatin-treated cells was detected by a plaque assay. We have previously identified a fourth non-structural protein (NS4) of BTV and GIV, showing that it interacts with lipid droplets in infected cells. Fluvastatin, which inhibits 3-hydroxy 3-methyl glutaryl CoA reductase in the mevalonic acid pathway, disrupts these NS4 interactions. These findings highlight the role of the lipid pathways in orbivirus replication and suggest a greater role for the membrane-enveloped orbivirus particles than previously recognised. Chemical intermediates of the mevalonic acid pathway were used to assess their potential to rescue orbivirus replication. Pre-treatment of IFNAR(−/−) mice with fluvastatin promoted their survival upon challenge with live BTV, although only limited protection was observed.

Published
2021
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28. Peruvian horse sickness virus and Yunnan orbivirus, isolated from vertebrates and mosquitoes in Peru and Australia

Author

Attoui, Houssam, Mendez-lopez, Maria Rosario, Rao, Shujing, Hurtado-Alendes, Ana, Lizaraso-Caparo, Frank, Mohd Jaafar, Fauziah, Samuel, Alan R., Belhouchet, Mourad, Pritchard, Lindsay I., Melville, Lorna, Weir, Richard P., Hyatt, Alex D., Davis, Steven S., Lunt, Ross, Calisher, Charles H., Tesh, Robert B., Fujita, Ricardo, and Mertens, Peter P.C.

Published
2009
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29. Serological Cross-Reactions between Expressed VP2 Proteins from Different Bluetongue Virus Serotypes

Author

Fay, Petra C., primary, Mohd Jaafar, Fauziah, additional, Batten, Carrie, additional, Attoui, Houssam, additional, Saunders, Keith, additional, Lomonossoff, George P., additional, Reid, Elizabeth, additional, Horton, Daniel, additional, Maan, Sushila, additional, Haig, David, additional, Daly, Janet M., additional, and Mertens, Peter P. C., additional

Published
2021
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32. Dialogue moléculaire des virus de l’encéphalite à tique et louping ill avec leur vecteur tique Ixodes ricinus

Author

Lemasson, Manon, Caignard, Grégory, Unterfinger, Yves, Attoui, Houssam, Bell-Sakyi, Lesley, Moutailler, Sara, Šimo, Ladislav, VITOUR, Damien, Saleh, Maria-Carla, Richardson, Jennifer, Lacour, Sandrine, Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), École nationale vétérinaire d'Alfort (ENVA), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Virologie UMR1161 (VIRO), and École nationale vétérinaire d'Alfort (ENVA)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.BBM.MN]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular Networks [q-bio.MN], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2021

33. Additional file 9 of Exploration of binary protein���protein interactions between tick-borne flaviviruses and Ixodes ricinus

Author

Lemasson, Manon, Caignard, Gr��gory, Unterfinger, Yves, Attoui, Houssam, Bell-Sakyi, Lesley, Hirchaud, Edouard, Moutailler, Sara, Johnson, Nicholas, Vitour, Damien, Richardson, Jennifer, and Lacour, Sandrine A.

Subjects
parasitic diseases
Abstract

Additional file 9. Homo sapiens orthologues of Ixodes ricinus genes and encoded proteins identified by yeast two-hybrid screening and gap repair.

Published
2021
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34. Additional file 7 of Exploration of binary protein���protein interactions between tick-borne flaviviruses and Ixodes ricinus

Author

Lemasson, Manon, Caignard, Gr��gory, Unterfinger, Yves, Attoui, Houssam, Bell-Sakyi, Lesley, Hirchaud, Edouard, Moutailler, Sara, Johnson, Nicholas, Vitour, Damien, Richardson, Jennifer, and Lacour, Sandrine A.

Subjects
parasitic diseases, fungi
Abstract

Additional file 7. Drosophila melanogaster orthologues of Ixodes ricinus genes and encoded proteins identified by yeast two-hybrid screening and gap repair.

Published
2021
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35. Dialogue moléculaire entre les virus de l’encéphalite à tiques et louping ill et leur arthropode vecteur, la tique Ixodes ricinus

Author

Lemasson, Manon, Caignard, Grégory, Unterfinger, Yves, Attoui, Houssam, Bell-Sakyi, Lesley, Hirchaud, Edouard, Moutailler, Sara, Johnson, Nick, VITOUR, Damien, Richardson, Jennifer, Lacour, Sandrine, Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), École nationale vétérinaire d'Alfort (ENVA), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Animal and Plant Health Agency [Addlestone, UK] (APHA), Virologie UMR1161 (VIRO), and École nationale vétérinaire d'Alfort (ENVA)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.BBM.MN]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular Networks [q-bio.MN], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2021

38. Additional file 8 of Exploration of binary protein���protein interactions between tick-borne flaviviruses and Ixodes ricinus

Author

Lemasson, Manon, Caignard, Gr��gory, Unterfinger, Yves, Attoui, Houssam, Bell-Sakyi, Lesley, Hirchaud, Edouard, Moutailler, Sara, Johnson, Nicholas, Vitour, Damien, Richardson, Jennifer, and Lacour, Sandrine A.

Subjects
parasitic diseases, education, fungi
Abstract

Additional file 8. Aedes aegypti orthologues of Ixodes ricinus genes and encoded proteins identified by yeast two-hybrid screening and gap repair.

Published
2021
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39. Uniformity of rotavirus strain nomenclature proposed by the Rotavirus Classification Working Group (RCWG)

Author

Matthijnssens, Jelle, Ciarlet, Max, McDonald, Sarah M., Attoui, Houssam, Bányai, Krisztián, Brister, J. Rodney, Buesa, Javier, Esona, Mathew D., Estes, Mary K., Gentsch, Jon R., Iturriza-Gómara, Miren, Johne, Reimar, Kirkwood, Carl D., Martella, Vito, Mertens, Peter P. C., Nakagomi, Osamu, Parreño, Viviana, Rahman, Mustafizur, Ruggeri, Franco M., Saif, Linda J., Santos, Norma, Steyer, Andrej, Taniguchi, Koki, Patton, John T., Desselberger, Ulrich, and Van Ranst, Marc

Published
2011
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41. Sequence analysis of bluetongue virus serotype 8 from the Netherlands 2006 and comparison to other European strains

Author

Maan, Sushila, Maan, Narender S., Ross-smith, Natalie, Batten, Carrie A., Shaw, Andrew E., Anthony, Simon J., Samuel, Alan R., Darpel, Karin E., Veronesi, Eva, Oura, Chris A.L., Singh, Karam P., Nomikou, Kyriaki, Potgieter, Abraham C., Attoui, Houssam, van Rooij, Eugene, van Rijn, Piet, De Clercq, Kris, Vandenbussche, Frank, Zientara, Stéphan, Bréard, Emmanuel, Sailleau, Corinne, Beer, Martin, Hoffman, Bernd, Mellor, Philip S., and Mertens, Peter P.C.

Published
2008
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44. Tick Importin-α Is Implicated in the Interactome and Regulome of the Cofactor Subolesin

Author

Artigas-Jerónimo, Sara, primary, Villar, Margarita, additional, Cabezas-Cruz, Alejandro, additional, Caignard, Grégory, additional, Vitour, Damien, additional, Richardson, Jennifer, additional, Lacour, Sandrine, additional, Attoui, Houssam, additional, Bell-Sakyi, Lesley, additional, Allain, Eleonore, additional, Nijhof, Ard M., additional, Militzer, Nina, additional, Pinecki Socias, Sophia, additional, and de la Fuente, José, additional

Published
2021
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45. Strategies for Assessing Arbovirus Genetic Variability in Vectors and/or Mammals

Author

Migné, Camille, Moutailler, Sara, Attoui, Houssam, Biologie moléculaire et immunologie parasitaires et fongiques (BIPAR), École nationale vétérinaire - Alfort (ENVA)-Laboratoire de santé animale, sites de Maisons-Alfort et de Normandie, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Virologie UMR1161 (VIRO), École nationale vétérinaire - Alfort (ENVA)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), French Agency for Food, Environmental and Occupational Health & Safety (ANSES, Cofunding Grant No. PHD2018-2021), National Research Institute for Agriculture, Food and Environment (INRAE), European Project: 727393,H2020,H2020-EU.3.2.1.1.,PALE-Blu(2017), École nationale vétérinaire - Alfort (ENVA)-Laboratoire de santé animale, sites de Maisons-Alfort et de Dozulé, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), European Project: 727393,PALE Blu, École nationale vétérinaire d'Alfort (ENVA)-Laboratoire de santé animale, sites de Maisons-Alfort et de Dozulé, and École nationale vétérinaire d'Alfort (ENVA)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, arboviruses, viruses, lcsh:R, genetic variability, lcsh:Medicine, Review, arthropods, tick-borne virus, insect-borne virus
Abstract

International audience; Animal arboviruses replicate in their invertebrate vectors and vertebrate hosts. They use several strategies to ensure replication/transmission. Their high mutation rates and propensity to generate recombinants and/or genome segment reassortments help them adapt to new hosts/emerge in new geographical areas. Studying arbovirus genetic variability has been used to identify indicators which predict their potential to adapt to new hosts and/or emergence and in particular quasi-species. Multiple studies conducted with insect-borne viruses laid the foundations for the "trade-off" hypothesis (alternation of host transmission cycle constrains arbovirus evolution). It was extrapolated to tick-borne viruses, where too few studies have been conducted, even though humans faced emergence of numerous tick-borne virus during the last decades. There is a paucity of information regarding genetic variability of these viruses. In addition, insects and ticks do not have similar lifecycles/lifestyles. Indeed, tick-borne viruses are longer associated with their vectors due to tick lifespan. The objectives of this review are: (i) to describe the state of the art for all strategies developed to study genetic variability of insect-borne viruses both in vitro and in vivo and potential applications to tick-borne viruses; and (ii) to highlight the specificities of arboviruses and vectors as a complex and diverse system.

Published
2020
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46. Identification of candidate molecular determinants of the vector competence of Ixodes ricinus for members of the tick-borne encephalitis virus complex

Author

Lemasson, Manon, Caignard, Grégory, Unterfinger, Yves, Attoui, Houssam, Bell-Sakyi, Lesley, Moutailler, Sara, VITOUR, Damien, Richardson, Jennifer, Lacour, Sandrine, Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), École nationale vétérinaire d'Alfort (ENVA), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Virologie UMR1161 (VIRO), and École nationale vétérinaire d'Alfort (ENVA)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2020

48. Coltiviruses and seadornaviruses in North America, Europe, and Asia

Author

Attoui, Houssam, Jaafar, Fauziah Mohd, de Micco, Philippe, and de Lamballerie, Xavier

Subjects
Insect viruses -- Genetic aspects, Insect viruses -- History, Epidemiology -- Research, Viral genetics -- Research
Abstract

Coltiviruses are tickborne viruses of the genus Coltivirus. The type species, Colorado tick fever virus (from North America), has been isolated from patients with flulike syndromes, meningitis, encephalitis, and other [...]

Published
2005

49. Low diversity of Alkhurma hemorrhagic fever virus, Saudi Arabia, 1994-1999

Author

Charrel, Remi N., Zaki, Ali Mohamed, Fakeeh, Mazen, Yousef, Amany Ibrahim, de Chesse, Reine, Attoui, Houssam, and de Lamballerie, Xavier

Subjects
Hemorrhagic fever -- Research, Hemorrhagic fever -- Genetic aspects, Hemorrhagic fever -- Case studies
Abstract

Alkhurma hemorrhagic fever virus (genus Flavivirus, AHFV) was recently identified as the agent of a viral hemorrhagic fever in Saudi Arabia and characterized serologically and genetically as a variant genotype [...]

Published
2005

50. Cypovirus

Author

Mertens, Peter P. C., primary, Attoui, Houssam, additional, and Sutton, Geoff, additional

Published
2011
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