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We used video-bronchoscopy for the purpose of laryngopharyngeal observation. The Narrow Band Imaging (NBI) system on the video-bronchoscope was useful for the differential diagnosis of benign and malignant micro-lesions and for estimating the range of intraepithelial cancer lesions. It was easy to manipulate the bronchoscope for otorhinolaryngologists since it could be inserted transnasally. After the observation, a biopsy was performed immediately through the channel. Proper diagnoses were obtained in most of cases.

7-[2-(2-Aminothiazol-4-yl)-2(Z)-methoxyiminoacetamido]-3(Z)- (4-methylthiazol-5-yl)vinyl-3-cephem-4-carboxylic acid (11, ME1206) and its 3-trans isomer (13) were prepared to test antibacterial activity. These compounds exhibited excellent antibacterial activity against both gram-positive and gram-negative bacteria, including beta-lactamase producing strains. The pivaloyloxymethyl esters (12 and 14) of the compounds (11 and 13) were prepared by esterification with pivaloyloxymethyl iodide. Among them, pivaloyloxymethyl 7-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]- 3(Z)-(4-methylthiazol-5-yl)vinyl-3-cephem-4-carboxylate (12, ME1207) showed good urinary recovery after oral administration in mice.