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Purpose: To report 2 cases of atypically located, non-nasal colobomas in the pediatric population. Observations: A 3-week-old female neonate with no known past ocular or medical history was diagnosed with temporal iris and chorioretinal coloboma with tractional membranes upon examination under anesthesia and imaging. A 9-year-old female with a history of bilateral sensorineural hearing loss and left mild hydronephrosis presented with a temporal chorioretinal coloboma associated with retinal detachment. Conclusions and importance: Very few cases of atypically located, non-nasal pediatric colobomas have been reported, and they lack a clear cause or mechanism of formation. Continued documentation of their occurrence and research into their formation at a molecular and embryological level are warranted to better understand their pathogenesis.

A 55-year-old female presented with a defective vision since childhood. The fundus examination revealed a well-demarcated macular excavation of 2 1/2 disc diameters. Optical coherence tomography (OCT) of both eyes revealed a bowl-like depression at the macula, absence of retinal pigment epithelium, and choroid with atrophic neurosensory retina. She was diagnosed as a case of bilateral macular coloboma. We wish to stress OCT and multimodal imaging's importance to diagnose macular colobomas and differentiate it from other disorders of the macula.

The left eye showed a superotemporal coloboma in the iris [Figure 1]a. Keywords: Atypical coloboma; chorioretinal coloboma; iris coloboma; superior coloboma EN Atypical coloboma chorioretinal coloboma iris coloboma superior coloboma 2665 2666 2 07/15/22 20220701 NES 220701 An 8-year-old male presented with diminution of vision in the left eye since childhood. Atypical coloboma, chorioretinal coloboma, iris coloboma, superior coloboma. [Extracted from the article]

Purpose To report a case of canine atypical chorioretinal coloboma where ophthalmoscopic, fluoroangiographic and optical coherence tomography characteristics are described. Animal Studied A 2-year-old Golden Retriever dog in which routine ophthalmoscopic examination allowed diagnosis of a posterior coloboma on the left eye. Procedures Retinography, fluorescein angiography, and optical coherence tomography were performed to characterize the lesion of the left fundus. Results Ophthalmoscopy revealed a pigmented circumscribed lesion dorsal to the optic nerve of the left fundus, surrounded by small areas of hyper-reflectivity and retinal vessels with an abnormal pattern. Fluoroangiography revealed a constant hypofluorescence of the defect and a complete altered vascular pattern associated with the coloboma. Optical coherence study demonstrated an important craterlike depression showing an atrophic neurosensory retina, and a lack of retinal pigment epithelium and choroidal tissue. Conclusions Fluoroangiographic and optical coherence tomographic studies of an atypical chorioretinal coloboma in a dog are reported for the first time. Both imaging techniques are of great importance to characterize this type of congenital defects. [ABSTRACT FROM AUTHOR]

Keywords: Atypical coloboma; lens coloboma; posterior embryotoxon; retinochoroidal coloboma EN Atypical coloboma lens coloboma posterior embryotoxon retinochoroidal coloboma 1445 1446 2 07/01/20 20200701 NES 200701 A 17-year-old female presented to us for routine ophthalmological evaluation. Atypical coloboma, lens coloboma, posterior embryotoxon, retinochoroidal coloboma. [Extracted from the article]