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21 results on '"Aulakh,Gurpreet Kaur"'

1. The Development and Validation of Radiopharmaceuticals Targeting Bacterial Infection

Author

Alberto, Signore, Ordonez, Alvaro A, Arjun, Chanda, Aulakh, Gurpreet Kaur, Beziere, Nicolas, Dadachova, Ekaterina, Ebenhan, Thomas, Granados, Ulises, Korde, Aruna, Jalilian, Amirreza, Lestari, Wening, Mukherjee, Archana, Petrik, Milos, Sakr, Tamer, Cuevas, Clara L Santos, Welling, Mick M, Zeevaart, Jan Rijn, Jain, Sanjay K, and Wilson, David M

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Biomedical Imaging, Infectious Diseases, Infection, Humans, Radiopharmaceuticals, Bacterial Infections, infection, antibiotics, radiotracer, molecular imaging, development, Nuclear Medicine & Medical Imaging, Clinical sciences
Abstract

The International Atomic Energy Agency organized a technical meeting at its headquarters in Vienna, Austria, in 2022 that included 17 experts representing 12 countries, whose research spanned the development and use of radiolabeled agents for imaging infection. The meeting focused largely on bacterial pathogens. The group discussed and evaluated the advantages and disadvantages of several radiopharmaceuticals, as well as the science driving various imaging approaches. The main objective was to understand why few infection-targeted radiotracers are used in clinical practice despite the urgent need to better characterize bacterial infections. This article summarizes the resulting consensus, at least among the included scientists and countries, on the current status of radiopharmaceutical development for infection imaging. Also included are opinions and recommendations regarding current research standards in this area. This and future International Atomic Energy Agency-sponsored collaborations will advance the goal of providing the medical community with innovative, practical tools for the specific image-based diagnosis of infection.

Published
2023

6. TLR10: An Intriguing Toll-Like Receptor with Many Unanswered Questions

Author

Rodrigues, Carolina Rego, Balachandran, Yadu, Aulakh, Gurpreet Kaur, and Singh, Baljit

Abstract

Background:Toll-like receptors (TLRs) are one of the first pattern recognition receptors found in the innate immune system. The TLR family has 12 members (TLR1–TLR9, TLR11–TLR13) in mice and 10 members (TLR1–TLR10) in humans, with TLR10 being the latest identified. Summary:Considerable research has been performed on TLRs; however, TLR10 is known as an orphan receptor for the lack of information on its signalling, role, and ligands. Even though there are recent studies pointing towards the potential TLR10 ligands, their function and signalling pathway are yet to be determined. Key Messages:This review gives an insight into recent findings on TLR10’s pro- and anti-inflammatory properties, with the goal of outlining existing results and indicating future research topics on this receptor. The paper succinctly reviews recent progress in TLR10, a transmembrane glycoprotein primarily expressed in organs with high immune cell density. Contradictory information regarding TLR10’s activity has been described, and its ligands and function are still in need of further elucidation, not only to understand its biology but also to potentially provide data to address gaps in our knowledge of immune responses in the host.

Published
2024
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17. RGD-tagged helical rosette nanotubes aggravate acute lipopolysaccharide-induced lung inflammation

Author

Singh Suri,Sarabjeet, Mills,Steven, Aulakh,Gurpreet Kaur, Rakotondradany,Felaniaina, Fenniri,Hicham, Singh,Baljit, Singh Suri,Sarabjeet, Mills,Steven, Aulakh,Gurpreet Kaur, Rakotondradany,Felaniaina, Fenniri,Hicham, and Singh,Baljit

Abstract

Sarabjeet Singh Suri1, Steven Mills1, Gurpreet Kaur Aulakh1, Felaniaina Rakotondradany2, Hicham Fenniri2, Baljit Singh11Department of Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon; 2National Institute for Nanotechnology and Department of Chemistry, Edmonton, CanadaAbstract: Rosette nanotubes (RNT) are a novel class of self-assembled biocompatible nanotubes that offer a built-in strategy for engineering structure and function through covalent tagging of synthetic self-assembling modules (G∧C motif). In this report, the G∧C motif was tagged with peptide Arg-Gly-Asp-Ser-Lys (RGDSK-G∧C) and amino acid Lys (K-G∧C) which, upon co-assembly, generate RNTs featuring RGDSK and K on their surface in predefined molar ratios. These hybrid RNTs, referred to as Kx/RGDSKy-RNT, where x and y refer to the molar ratios of K-G∧C and RGDSK–G∧C, were designed to target neutrophil integrins. A mouse model was used to investigate the effects of intravenous Kx/RGDSKy-RNT on acute lipopolysaccharide (LPS)-induced lung inflammation. Healthy male C57BL/6 mice were treated intranasally with Escherichia coli LPS 80 µg and/or intravenously with K90/RGDSK10-RNT. Here we provide the first evidence that intravenous administration of K90/RGDSK10-RNT aggravates the proinflammatory effect of LPS in the mouse. LPS and K90/RGDSK10-RNT treatment groups showed significantly increased infiltration of polymorphonuclear cells in bronchoalveolar lavage fluid at all time points compared with the saline control. The combined effect of LPS and K90/RGDSK10-RNT was more pronounced than LPS alone, as shown by a significant increase in the expression of interleukin-1ß, MCP-1, MIP-1, and KC-1 in the bronchoalveolar lavage fluid and myeloperoxidase activity in the lung tissues. We conclude that K90/RGDSK10-RNT promotes acute lung inflammation, and when used along with LPS, leads to exaggerated immune response in the lu

Published
2011

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