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2. Left atrial volume indexed for height2 is a new sensitive marker for subclinical cardiac organ damage in female hypertensive patients

Author

Airale, L, Paini, A, Ianniello, E, Mancusi, C, Moreo, A, Vaudo, G, Avenatti, E, Salvetti, M, Bacchelli, S, Izzo, R, Sormani, P, Arrivi, A, Muiesan, M, Esposti, D, Giannattasio, C, Pucci, G, De Luca, N, Milan, A, Airale L., Paini A., Ianniello E., Mancusi C., Moreo A., Vaudo G., Avenatti E., Salvetti M., Bacchelli S., Izzo R., Sormani P., Arrivi A., Muiesan M. L., Esposti D. D., Giannattasio C., Pucci G., De Luca N., Milan A., Airale, L, Paini, A, Ianniello, E, Mancusi, C, Moreo, A, Vaudo, G, Avenatti, E, Salvetti, M, Bacchelli, S, Izzo, R, Sormani, P, Arrivi, A, Muiesan, M, Esposti, D, Giannattasio, C, Pucci, G, De Luca, N, Milan, A, Airale L., Paini A., Ianniello E., Mancusi C., Moreo A., Vaudo G., Avenatti E., Salvetti M., Bacchelli S., Izzo R., Sormani P., Arrivi A., Muiesan M. L., Esposti D. D., Giannattasio C., Pucci G., De Luca N., and Milan A.

Abstract

Left atrial enlargement (LAe) is a subclinical marker of hypertensive-mediated organ damage, which is important to identify in cardiovascular risk stratification. Recently, LA indexing for height was suggested as a more accurate marker of defining LAe. Our aim was to test the difference in LAe prevalence using body surface area (BSA) and height2 definitions in an essential hypertensive population. A total of 441 essential hypertensive patients underwent complete clinical and echocardiographic evaluation. Left atrial volume (LAV), left ventricular morphology, and systolic-diastolic function were evaluated. LAe was twice as prevalent when defined using height2 (LAeh2) indexation rather than BSA (LAeBSA) (51% vs. 23%, p < 0.001). LAeh2, but not LAeBSA, was more prevalent in females (p < 0.001). Males and females also differed in left ventricular hypertrophy (p = 0.046) and left ventricular diastolic dysfunction (LVDD) indexes (septal Em/Etdi: p = 0.009; lateral Em/Etdi: p = 0.003; mean Em/Etdi: p < 0.002). All patients presenting LAeBSA also met the criteria for LAeh2. According to the presence/absence of LAe, we created three groups (Norm = BSA−/h2-; DilH = BSA−/h2+; DilHB = BSA+/h2+). The female sex prevalence in the DilH group was higher than that in the other two groups (Norm: p < 0.001; DilHB: p = 0.036). LVH and mean and septal Em/Etdi increased from the Norm to the DilH group and from the DilH to the DilHB group (p < 0.05 for all comparisons). These results show that LAeh2 identified twice as many patients as comparing LAe to LAeBSA, but that both LAeh2 and LAeBSA definitions were associated with LVH and LVDD. In female patients, the LAeh2 definition and its sex-specific threshold seem to be more sensitive than LAeBSA in identifying chamber enlargement.

Published
2021

9. Poster session: Aortic stenosis

Author

Magnino, C, Omedeʼ, P, Avenatti, E, Chiarlo, M, Presutti, D, Bucca, C, Moretti, C, Gaita, F, Veglio, F, and Milan, A

Published
2012

10. Proximal aortic diameter evolution in hypertensive patients with mild-to-moderate aortic dilatation: a 5-year follow-up experience

Author

Leone, D., Cina, Alessandro, Tosello, F., Sabia, Luca, Vallelonga, F., Avenatti, E., Astarita, A., Mingrone, Geltrude, Veglio, F., Ridolfi, L., Milan, A., Cina A., Sabia L., Mingrone G. (ORCID:0000-0003-2021-528X), Leone, D., Cina, Alessandro, Tosello, F., Sabia, Luca, Vallelonga, F., Avenatti, E., Astarita, A., Mingrone, Geltrude, Veglio, F., Ridolfi, L., Milan, A., Cina A., Sabia L., and Mingrone G. (ORCID:0000-0003-2021-528X)

Abstract

BACKGROUND: Aortic dilatation is common in hypertensive patients and is associated with higher risk of cardiovascular events. Parameters predicting further dilatation during lifetime are poorly understood. AIM: To predict the midterm aortic diameter evolution in a cohort of hypertensive patients with known aortic dilatation at Sinus of Valsalva (SOV) level. METHODS: We prospectively analyzed a cohort of essential hypertensive outpatients without any other known risk factor for aortic dilatation. They underwent serial echocardiographic evaluations from 2003 to 2016. RESULTS: Two hundred and forty-two hypertensive outpatients with a mild-to-moderate (37-53 mm) aortic dilatation were followed up for at least 5 years. Mean growth rate was 0.08 ± 0.35 mm/year. No clinical or anthropometric parameters were significantly different in patients with and without aortic diameter increase. Aortic z score (number of standard deviations from the average value observed in the general population) at baseline was inversely associated with growth rate (R 0.04, P < 0.05). Aortic diameter at first visit, demographic and echocardiographic variables were major determinants of aortic diameter at second visit, accounting for about 90% of its total variability. CONCLUSION: Mean growth rate of proximal aorta in hypertensive patients with known aortic dilatation was of about 0.1 mm/year. Dilatation over time is slower in patients with increased rather than normal aortic z score. Eventually, it could be possible to reliably predict aortic diameter at few months from first visit.

Published
2020

12. Aortic root dilatation in hypertensive patients: A multicenter survey in echocardiographic practice

Author

Cuspidi, C, Negri, F, Salvetti, M, Lonati, L, Sala, C, Capra, A, Milan, A, Danzi, G, Morganti, A, Bonanomi, C, Settimi, E, Scanziani, E, Giannattasio, C, Trocino, G, Casati, A, Chiappa, L, Paggi, A, Degli Esposti, D, Bacchelli, S, Ganau, A, Oppo, A, Grandi, A, Nicolini, E, Mongiardi, C, Branzi, G, Parati, G, Longo, M, Valerio, C, Marconi, M, Macca, G, Avenatti, E, Veglio, F, Muiesan, M, Paini, A, Galbassini, G, Monteduro, C, Giudici, V, Re, A, Pellizzoli, S, Robustelli, F, Rao, M, Iovino, G, Arcucci, O, De Luca, N, Tocci, G, Ciavarella, M, Volpe, M, Vaccarella, A, Veglia, M, Bonanomi C, Settimi E, Danzi GB, Scanziani E, Giannattasio C, Trocino G, Casati A, Chiappa L, Paggi A, Degli Esposti D, Bacchelli S, Ganau A, Oppo A, Grandi AM, Nicolini E, Mongiardi C, Lonati L, Branzi G, Parati G, Longo M, Valerio C, Marconi M, Macca G, Milan A, Avenatti E, Veglio F, Muiesan ML, Salvetti M, Paini A, Galbassini G, Monteduro C, Giudici V, Re A, Pellizzoli S, Robustelli F, Rao MA, Iovino GL, Arcucci O, De Luca N, Tocci G, Ciavarella M, Volpe M, Vaccarella A, Veglia MG., Cuspidi, C, Negri, F, Salvetti, M, Lonati, L, Sala, C, Capra, A, Milan, A, Danzi, G, Morganti, A, Bonanomi, C, Settimi, E, Scanziani, E, Giannattasio, C, Trocino, G, Casati, A, Chiappa, L, Paggi, A, Degli Esposti, D, Bacchelli, S, Ganau, A, Oppo, A, Grandi, A, Nicolini, E, Mongiardi, C, Branzi, G, Parati, G, Longo, M, Valerio, C, Marconi, M, Macca, G, Avenatti, E, Veglio, F, Muiesan, M, Paini, A, Galbassini, G, Monteduro, C, Giudici, V, Re, A, Pellizzoli, S, Robustelli, F, Rao, M, Iovino, G, Arcucci, O, De Luca, N, Tocci, G, Ciavarella, M, Volpe, M, Vaccarella, A, Veglia, M, Bonanomi C, Settimi E, Danzi GB, Scanziani E, Giannattasio C, Trocino G, Casati A, Chiappa L, Paggi A, Degli Esposti D, Bacchelli S, Ganau A, Oppo A, Grandi AM, Nicolini E, Mongiardi C, Lonati L, Branzi G, Parati G, Longo M, Valerio C, Marconi M, Macca G, Milan A, Avenatti E, Veglio F, Muiesan ML, Salvetti M, Paini A, Galbassini G, Monteduro C, Giudici V, Re A, Pellizzoli S, Robustelli F, Rao MA, Iovino GL, Arcucci O, De Luca N, Tocci G, Ciavarella M, Volpe M, Vaccarella A, and Veglia MG.

Abstract

Background and aim. Aortic root dilatation (ARD) is a cardiovascular phenotype of adverse prognostic value; its prevalence has been mostly investigated in population-based samples and selected hypertensive cohorts. Data from clinical practice are rather scant. Thus, we examined the prevalence and correlates of ARD in a large sample of hypertensive patients referred by general practitioners for a routine echocardiographic examination. Methods. A total of 2229 untreated and treated hypertensive subjects (mean age 62 years) referred to 17 outpatient echocardiographic laboratories across Italy for detection of hypertensive subclinical cardiac damage were included in the study. ARD was defined by aortic diameter exceeding 3.7 cm in women and 3.9 cm in men. Results. ARD was found in 263 patients, with an overall prevalence of 11.8% (16.9% in men and 6.2% in women, p < 0.05). In multivariate regression analyses, body surface area (BSA), left ventricular (LV) mass and age were in ranking order the most important correlates of aortic root size in the whole population study as well as in men. In women, LV mass and its derivative indexes were the most important independent variables associated to aortic root size. Conclusions. This multicenter nationwide survey indicates that ARD is a frequent cardiovascular phenotype in hypertensives referred to echo-labs for detection of hypertensive organ damage. BSA, LV mass and age are the most important correlates of this phenotype. The hierarchical order of these factors differs between genders, LV mass being the strongest independent variable in women. © 2011 Scandinavian Foundation for Cardiovascular Research

Published
2011

13. Prevalence and correlates of echocardiographic left atrial enlargement in hypertensive outpatients in clinical practice

Author

CUSPIDI, CESARE, NEGRI, FRANCESCA, CAPRA, ANNA CLARA MARIA, GIANNATTASIO, CRISTINA, PARATI, GIANFRANCO, Lonati, L, Muiesan, ML, Milan, A, Sala, C, Danzi, GB, Longo, M, Morganti, A, Bonanomi, C, Settimi, E, Capra, A, Scanziani, E, Trocino, G, Casati, A, Chiappa, L, Paggi, A, Degli Esposti, D, Bacchelli, S, Ganau, A, Oppo, A, Grandi, AM, Nicolini, E, Mongiardi, C, Branzi, G, Valerio, C, Marconi, M, Macca, G, Avenatti, E, Veglio, F, Salvetti, M, Paini, A, Galbassini, G, Monteduro, C, Negri, F, Giudici, V, Re, A, Cuspidi, C, Pellizzoli, S, Robustelli, F, Rao, MA, Iovino, GL, Arcucci, O, De Luca, N, Tocci, G, Ciavarella, M, Volpe, M, Vaccarella, A, Veglia, MG, Cuspidi, C, Negri, F, Lonati, L, Muiesan, M, Capra, A, Milan, A, Sala, C, Danzi, G, Longo, M, Morganti, A, Bonanomi, C, Settimi, E, Scanziani, E, Giannattasio, C, Trocino, G, Casati, A, Chiappa, L, Paggi, A, Degli Esposti, D, Bacchelli, S, Ganau, A, Oppo, A, Grandi, A, Nicolini, E, Mongiardi, C, Branzi, G, Parati, G, Valerio, C, Marconi, M, Macca, G, Avenatti, E, Veglio, F, Salvetti, M, Paini, A, Galbassini, G, Monteduro, C, Giudici, V, Re, A, Pellizzoli, S, Robustelli, F, Rao, M, Iovino, G, Arcucci, O, De Luca, N, Tocci, G, Ciavarella, M, Volpe, M, Vaccarella, A, and Veglia, M

Subjects
Male, medicine.medical_specialty, Physiology, Population, Left atrium, Cardiomegaly, echocardiography, hypertension, left atrium (la), left ventricular mass, Left ventricular mass, Left atrial enlargement, left atrium (LA), hypertension, left ventricular mass, echocardiography, Risk Factors, Internal medicine, Echocardiography, Hypertension, Left atrium (LA), Aged, Female, Heart Atria, Humans, Hypertrophy, Left Ventricular, Italy, Middle Aged, Prevalence, Internal Medicine, medicine, Left atrial enlargement, education, Body surface area, education.field_of_study, business.industry, Mean age, General Medicine, Hypertrophy, medicine.disease, Left Ventricular, Clinical Practice, medicine.anatomical_structure, Cohort, Cardiology, MED/09 - MEDICINA INTERNA, business, Heart atrium
Abstract

Prevalence of left atrial enlargement (LAE) in hypertension has been mostly assessed in population-based samples and selected hypertensive groups. A few data are available in clinical practice. We examined LAE prevalence and severity in a cohort of hypertensive patients referred by general practitioners to a routine echocardiographic examination. A total of 2170 hypertensive individuals (mean age 62 years, 53% men) referred by practitioners to 17 outpatient echocardiographic laboratories across Italy for detection of hypertensive cardiac disease were included in the study. LAE was defined as: A) absolute LA diameter >4.0 cm in men and >3.8 cm in women; B) LA diameter normalized to body surface area (BSA) >2.3 cm/m2 in both sexes. Left atrial enlargement was graded as mild, moderate, and severe according to Lang’s report. Patients with LAE were 38% by criterion A, and 20% by criterion B. A moderate/severe increase in LA size was present in 34% (A) and 32% (B) of patients with LAE. Severe LAE was 3.3-fold (A) and 2.6-fold (B) more frequent in women than in men. Left ventricular mass was the strongest correlate of absolute LA diameter as well as of normalized LA diameter, after age. Left atrial enlargement defined either by absolute or normalized LA diameter is a frequent cardiac phenotype in hypertensive patients referred to echo-labs in clinical practice. This cardiac parameter is closely related to LV mass and its severity is highly prevalent in women.

Published
2011

14. Poster session 2: Thursday 4 December 2014, 08:30-12:30Location: Poster area

Author

Domingos, J, Augustine, D, Leeson, P, Noble, J, Doan, HL, Boubrit, L, Cheikh-Khalifa, R, Laveau, F, Djebbar, M, Pousset, F, Isnard, R, Hammoudi, N, Lisi, M, Cameli, M, Di Tommaso, C, Curci, V, Reccia, R, Maccherini, M, Henein, MY, Mondillo, S, Leitman, M, Vered, Z, Rashid, H, Yalcin, MU, Gurses, KM, Kocyigit, D, Evranos, B, Yorgun, H, Sahiner, L, Kaya, B, Aytemir, K, Ozer, N, Bertella, E, Petulla', M, Baggiano, A, Mushtaq, S, Russo, E, Gripari, P, Innocenti, E, Andreini, D, Tondo, C, Pontone, G, Necas, J, Kovalova, S, Hristova, K, Shiue, I, Bogdanva, V, Teixido Tura, G, Sanchez, V, Rodriguez-Palomares, J, Gutierrez, L, Gonzalez-Alujas, T, Garcia-Dorado, D, Forteza, A, Evangelista, A, Timoteo, AT, Aguiar Rosa, S, Cruz Ferreira, R, Campbell, R, Carrick, D, Mccombe, C, Tzemos, N, Berry, C, Sonecki, P, Noda, M, Setoguchi, M, Ikenouchi, T, Nakamura, T, Yamamoto, Y, Murakami, T, Katou, Y, Usui, M, Ichikawa, K, Isobe, M, Kwon, B, Roh, J, Kim, H, Ihm, S, Barron, AJ, Francis, D, Mayet, J, Wensel, R, Kosiuk, J, Dinov, B, Bollmann, A, Hindricks, G, Breithardt, O, Rio, P, Moura Branco, L, Galrinho, A, Cacela, D, Pinto Teixeira, P, Afonso Nogueira, M, Pereira-Da-Silva, T, Abreu, J, Teresa Timoteo, A, Pavlyukova, E, Tereshenkova, E, Karpov, R, Piatkowski, R, Kochanowski, J, Opolski, G, Barbier, P, Mirea, O, Guglielmo, M, Savioli, G, Cefalu, C, Pudil, R, Horakova, L, Rozloznik, M, Balestra, C, Rimbas, R, Enescu, O, Calin, S, Vinereanu, D, Karsenty, C, Hascoet, S, Hadeed, K, Semet, F, Dulac, Y, Alacoque, X, Leobon, B, Acar, P, Dharma, S, Sukmawan, R, Soesanto, A, Vebiona, K, Firdaus, I, Danny, S, Driessen, MM, Sieswerda, G, Post, M, Snijder, R, Van Dijk, A, Leiner, T, Meijboom, F, Chrysohoou, C, Tsitsinakis, G, Tsiachris, D, Aggelis, A, Herouvim, E, Vogiatzis, I, Pitsavos, C, Koulouris, G, Stefanadis, C, Erdei, T, Edwards, J, Braim, D, Yousef, Z, Fraser, A, Avenatti, E, Magnino, C, Omede', P, Presutti, D, Moretti, C, Iannaccone, A, Ravera, A, Gaita, F, Milan, A, Veglio, F, Scali, M, Simioniuc, A, Fusini, L, Dini, F, Okura, H, Murata, E, Kataoka, T, Mikaelpoor, A, Ojaghi Haghighi, S, Alizadeasl, A, Sharifi-Zarchi, A, Zaroui, A, Ben Halima, M, Mourali, M, Mechmeche, R, Rodriguez Palomares, JF, Maldonado, G, Garcia, G, Otaegui, I, Garcia Del Blanco, B, Teixido, G, Gonzalez Alujas, M, Garcia Dorado, D, Godinho, AR, Correia, A, Rangel, I, Rocha, A, Rodrigues, J, Araujo, V, Almeida, P, Macedo, F, Maciel, M, Rekik, B, Mghaieth, F, Aloui, H, Boudiche, S, Jomaa, M, Ayari, J, Tabebi, N, Farhati, A, Mourali, S, Dekleva, M, Markovic-Nikolic, N, Zivkovic, M, Stankovic, A, Boljevic, D, Korac, N, Beleslin, B, Arandjelovic, A, Ostojic, M, Galli, E, Guirette, Y, Auffret, V, Daudin, M, Fournet, M, Mabo, P, Donal, E, Chin, CW, Luo, E, Hwan, J, White, A, Newby, D, Dweck, M, Carstensen, HG, Larsen, LH, Hassager, C, Kofoed, KF, Jensen, JS, Mogelvang, R, Kowalczyk, M, Debska, M, Kolesnik, A, Dangel, J, Kawalec, W, Migliore, R, Adaniya, M, Barranco, M, Miramont, G, Gonzalez, S, Tamagusuku, H, Davidsen, ES, Kuiper, KK, Matre, K, Gerdts, E, Igual Munoz, B, Maceira Gonzalez, A, Erdociain Perales, M, Estornell Erill, J, Valera Martinez, F, Miro Palau, V, Piquer Gil, M, Sepulveda Sanchez, P, Cervera Zamora, A, Montero Argudo, A, Placido, R, Silva Marques, J, Magalhaes, A, Guimaraes, T, Nobre E Menezes, M, Goncalves, S, Ramalho, A, Robalo Martins, S, Almeida, A, Nunes Diogo, A, Abid, L, Ben Kahla, S, Charfeddine, S, Abid, D, Kammoun, S, Tounsi, A, Hammami, R, Triki, F, Akrout, M, Mallek, S, Hentati, M, Sirbu, CF, Berrebi, A, Huber, A, Folliguet, T, Yang, LT, Shih, J, Liu, Y, Li, Y, Tsai, L, Luo, C, Tsai, W, Babukov, R, Bartosh, F, Bazilev, V, Muraru, D, Cavalli, G, Addetia, K, Miglioranza, M, Veronesi, F, Mihaila, S, Tadic, M, Cucchini, U, Badano, L, Lang, R, Miyazaki, S, Slavich, M, Miyazaki, T, Figini, F, Lativ, A, Chieffo, A, Montrfano, M, Alfieri, O, Colombo, A, Agricola, E, Liu, D, Hu, K, Herrmann, S, Stoerk, S, Kramer, B, Ertl, G, Bijnens, B, Weidemann, F, Brand, M, Butz, T, Tzikas, S, Van Bracht, M, Roeing, J, Wennemann, R, Christ, M, Grett, M, Trappe, HJ, Scherzer, S, Geroldinger, A, Krenn, L, Roth, C, Gangl, C, Maurer, G, Rosenhek, R, Neunteufl, T, Binder, T, Bergler-Klein, J, Martins, E, Pinho, T, Leite, S, Azevedo, O, Belo, A, Campelo, M, Amorim, S, Rocha-Goncalves, F, Goncalves, L, Silva-Cardoso, J, Ahn, H, Kim, K, Jeon, H, Youn, H, Haland, T, Saberniak, J, Leren, I, Edvardsen, T, Haugaa, K, Ziolkowska, L, Boruc, A, Turska-Kmiec, A, Zubrzycka, M, Monivas Palomero, V, Mingo Santos, S, Goirigolzarri Artaza, J, Rodriguez Gonzalez, E, Rivero Arribas, B, Castro Urda, V, Dominguez Rodriguez, F, Mitroi, C, Gracia Lunar, I, Fernadez Lozano, I, Palecek, T, Masek, M, Kuchynka, P, Fikrle, M, Spicka, I, Rysava, R, Linhart, A, Hasselberg, N, Borgquist, R, Platonov, P, Ancona, R, Comenale Pinto, S, Caso, P, Coopola, M, Arenga, F, Rapisarda, O, D'onofrio, A, Sellitto, V, Calabro, R, Rosca, M, Popescu, B, Calin, A, Mateescu, A, Beladan, C, Jalba, M, Rusu, E, Zilisteanu, D, Ginghina, C, Pressman, G, Cepeda-Valery, B, Romero-Corral, A, Moldovan, R, Saenz, A, Orban, M, Samuel, S, Fijalkowski, M, Fijalkowska, M, Gilis-Siek, N, Blaut, K, Galaska, R, Sworczak, K, Gruchala, M, Nowak, R, Ikonomidis, I, Triantafyllidi, H, Trivilou, P, Tzortzis, S, Papadopoulos, C, Pavlidis, G, Paraskevaidis, I, Lekakis, J, Padiyath, A, Li, L, Xiao, Y, Danford, D, Kutty, S, Kaymaz, C, Aktemur, T, Poci, N, Ozturk, S, Akbal, O, Yilmaz, F, Tokgoz Demircan, H, Kirca, N, Tanboga, I, Ozdemir, N, Greiner, S, Jud, A, Aurich, M, Hess, A, Hilbel, T, Hardt, S, Katus, H, D'ascenzi, F, Alvino, F, Focardi, M, Solari, M, Bonifazi, M, Konopka, M, Krol, W, Klusiewicz, A, Burkhard, K, Chwalbinska, J, Pokrywka, A, Dluzniewski, M, Braksator, W, King, GJ, Coen, K, Gannon, S, Fahy, N, Kindler, H, Clarke, J, Iliuta, L, Rac-Albu, M, Cortez-Dias, N, Francisco, A, Silva, G, Kyu, K, Kong, W, Songco, G, Galupo, M, Castro, M, Shin Hnin, W, Ronald Lee, C, Poh, K, Milazzo, V, Di Stefano, C, Tosello, F, Leone, D, Sabia, L, Sobrero, G, Maule, S, Jamiel, AM, Ahmed, AM, Farah, I, Al-Mallah, MH, Petroni, R, Magnano, R, Bencivenga, S, Di Mauro, M, Petroni, S, Altorio, S, Romano, S, Penco, M, Kumor, M, Lipczynska, M, Klisiewicz, A, Wojcik, A, Konka, M, Kozuch, K, Szymanski, P, Hoffman, P, Rimbas, M, Reynaud, A, Lund, L, Persson, H, Hage, C, Oger, E, Linde, C, Daubert, J, Maria Oliveira Lima, M, Costa, H, Gomes Da Silva, M, Noman Alencar, M, Carmo Pereira Nunes, M, Costa Rocha, M, Siala, A, Ozawa, K, Funabashi, N, Takaoka, H, Kobayashi, Y, Matsumura, Y, Wada, M, Hirakawa, D, Yasuoka, Y, Morimoto, N, Takeuchi, H, Kitaoka, H, Sugiura, T, Lakkas, L, Naka, K, Ntounousi, E, Gkirdis, I, Koutlas, V, Bechlioulis, A, Pappas, K, Katsouras, C, Siamopoulos, K, Michalis, L, Evangelou, D, Kalaitzidis, R, Tzeltzes, G, Nakas, G, Generati, G, Bandera, F, Pellegrino, M, Labate, V, Alfonzetti, E, Guazzi, M, Zagatina, A, Zhuravskaya, N, Al-Mallah, M, Alsaileek, A, Qureshi, W, Peyre, M, Amadieu, R, Yamanaka, Y, Sotomi, Y, Iwakura, K, Inoue, K, Toyoshima, Y, Tanaka, K, Oka, T, Tanaka, N, Orihara, Y, Fujii, K, Soulat-Dufour, L, Lang, S, Boyer-Chatenet, L, Van Der Vynckt, C, Ederhy, S, Adavane, S, Haddour, N, Boccara, F, Cohen, A, Huitema, M, Boerman, S, Vorselaars, V, Grutters, J, Gopal, AS, Saha, S, Toole, R, Kiotsekoglou, A, Cao, J, Reichek, N, Meyer, CG, Altiok, E, Al Ateah, G, Lehrke, M, Becker, M, Lotfi, S, Autschbach, R, Marx, N, Hoffmann, R, Frick, M, Nemes, A, Sepp, R, Kalapos, A, Domsik, P, Forster, T, Caro Codon, J, Blazquez Bermejo, Z, Lopez Fernandez, T, Valbuena Lopez, SC, Iniesta Manjavacas, AM, De Torres Alba, F, Dominguez Melcon, F, Pena Conde, L, Moreno Yanguela, M, Lopez-Sendon, JL, Lengyel, C, Orosz, A, Varkonyi, T, Rendon, J, Saldarriaga, CI, Duarte, N, Foldeak, D, Borbenyi, Z, Hamdy, A, Fereig, H, Nabih, M, Abdel-Aziz, A, Ali, A, Broyd, C, Wielandts, JY, De Buck, S, Michielsen, K, Louw, R, Garweg, C, Nuyts, J, Ector, J, Maes, F, Heidbuchel, H, Gillis, K, Bala, G, Tierens, S, Cosyns, B, Maurovich-Horvat, P, Horvath, T, Jermendy, A, Celeng, C, Panajotu, A, Bartykowszki, A, Karolyi, M, Tarnoki, A, Jermendy, G, and Merkely, B

Subjects
medicine.medical_specialty, biology, Early Repolarization Pattern, business.industry, Athletes, Physical therapy, medicine, Radiology, Nuclear Medicine and imaging, General Medicine, Cardiology and Cardiovascular Medicine, business, biology.organism_classification
Published
2014

15. VIEWING ONLY POSTERS1323Evaluation of right ventricular transverse strain and strain rate in patients with acute ST-segment elevation myocardial infarction: a cardiac magnetic resonance feature tracking study1333Cardiac resynchronization in ischemic heart failure patients: a comparison between therapy guided by cardiac magnetic resonance imaging and 2D-speckle tracking echocardiography1338Cardiac magnetic resonance versus bisphosphonate scintigraphy for diagnosis of cardiac amyloidosis1341Strain relaxation index, a novel tagged MRI-derived diastolic function parameter, is impaired in metabolic syndrome1349Global Longitudinal Strain Predicts Chronic Myocardial Infarction in Patients with Normal Ejection Fraction1352Optimal Dose Of Dobutamine During Low-Dose Dobutamine Stress Echocardiography In Correctly Identify Viable Segments On Cardiovascular Magnetic Resonance1368Absolute wall thickening and left ventricular ejection fraction–a unifying theory of myocardial contraction and heart failure?1376Transient St Elevation in Acs Like Myocarditis1379Patients after Fontan with a “total cavopulmonary connection” Fontan modification develop more collateral flow compared to “old-fashioned” Fontan modifications1387A MRI–derived 3D patient specific model for fibrosis quantification in atrial fibrillation1391Scar burden and survival in patients with ischemic cardiomyopathy and poor LV ejection fraction1392Relation of inflammatory markers with myocardial and microvascular injury in patients with reperfused ST- elevation myocardial infarction1406Equivalence of segmented conventional and fast single-shot late gadolinium enhancement (LGE) techniques for1410Cardiac Mri Appearances of Tuberculosis - A Review of Varied Presentations in India1415Atheroma burden, cardiac remodelling and epicardial fat: A comparison between healthy South Asian and European adults using Whole Body Cardiovascular MR1418Symptomatic Ventricular Arrhythmias: Diagnostic Yield of Cardiac Magnetic Resonance1421CMR assessment of aortic stiffness in asymptomatic low risk patients with type 2 diabetes mellitus1436Shock index as a predictor of myocardial damage and clinical outcome in ST-elevation myocardial infarction1451Combined biomarker testing for the prediction of microvascular obstruction after primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction1452A novel oscillometric technique compared with cardiac magnetic resonance for the assessment of aortic pulse wave velocity in ST-segment elevation myocardial infarction1456Aorto-pulmonary collaterals evaluated by CMR is associated to reduced “effective” cardiac index late after Fontan palliation1458Evaluation of pulmonary transit time and Pulmonary Blood Volume with first-pass perfusion CMR imaging in adult with repaired Congenital Heart disease1459Prognostic value of the cardiac magnetic resonance as a predictor of improvement in ventricular function after TakoTsubo syndrome1462Diagnostic performance of ECG detection of left atrial enlargement in patients with arterial hypertension relative to the cardiac magnetic resonance gold-standard: impact of obesity1463Utility of cardiac magnetic resonance imaging for diagnosis of cardiac sarcoidosis and prediction of therapeutic effects in patients with complete heart block and implanted magnetic resonance-conditional pacemaker: A multicenter study1467Cardiac magnetic resonance late gadolinium enhancement in patients with genetic dilated cardiomyopathy14712.Left ventricular hypertrophy in hypertensive patients–comparison of Cardiac Magnetic Resonance and Echocardiographic analysis of morphological and functional LV-parameters1472Is Angiographic Perfusion Score assessed in patients with acute myocardial infarction correlated with Cardiac Magnetic Resonance infarct size and N-terminal pro-brain natriuretic peptide in 6-month follow-up1476Cardiac Magnetic Resonance Patterns of Left Ventricular Diastolic Function In Hypertrophic Cardiomyopathy1477Impact of platelet volume on thrombus burden and tissue reperfusion in patients with STEMI treated with primary angioplasty: MRI study1479Right ventricle systolic function assessment and its prognostic implications in cardiac amyloidosis1484Cardiac MRI - an important tool in the evaluation of multsystemic inflamatory diseases. An Erdheim-Chester Disease case report1485Predictive value of cardiac magnetic resonance for future adverse cardiac events in patients with ST-segment elevation myocardial infarction1486Time-to-treatment but not thrombectomy influence infarct size and microvascular obstruction in patients with acute ST-segment elevation myocardial infarction treated with primary coronary intervention1489Primary PCI versus Early Routine Post Fibrinolysis PCI for ST Elevation Myocardial Infarction1490Evaluation of ventricular function in Fontan patients undergoing feature tracking magnetic resonance strain1491Impacts of atrialized right ventricle and left ventricular displacement in Ebstein's anomaly on left ventricular function assessed by cardiovascular MRI1494Final diagnosis for patients presenting with chest pain, electrocardiographic changes or troponin rise and normal coronary arteries: insights from Cardiovascular MRI in our population1495Early Predictive Factors of LV Remodeling after STEMI; Assessment by Coronary Angiogram and Cadiovascular Magnetic Resonance1497The Pathobiologic Mechanisms and the Prognostic Meaning of t wave Inversion in Acute Myocarditis. a Study Performed by Cardiac Magnetic Resonance1501The Influence of Left Atrial Function on Exercise Tolerance in Patients with Heart Failure and Preserved Ejection Fraction: A Cardiac Magnetic Resonance Feature Tracking Study1504Microvascular Obstruction in Patients with Anterior ST-Elevation Myocardial Infarction who Underwent Primary Percutaneous Coronary Intervention: Predictors and Impact on the Left Ventricular Function1508Histological Validation of ECV Quantification by Cardiac Magnetic Resonance T1 Mapping in Cardiac Amyloidosis1513Comparative Evaluation of Flow Quantification Across the Atrioventricular Valve in Patients with Functional Univentricular Heart After Fontan's Surgery and Healthy Controls: Measurement by 4D Flow Magnetic Resonance Imaging and Streamline Visualization1515Does arterial switch for d-transposition of the great arteries alter myocardial deformation of the ventricles?1527Accuracy of T1 Mapping by multi-professional CMR operators to predict myocardial infarct1531Detecting hypertensive heart disease: the additive value of cardiovascular magnetic resonance imaging1534Diagnostic Performance of Cardiac Magnetic Resonance Strain Parameters in Assesment of Myocardial Ischemia1535Relationships between left ventricular filling pressures and longitudinal dysfunction with myocardial fibrosis in uncomplicated hypertensive patients1539Predictive Clinical Factors of Tissue Damage Severity in Reperfused Acute Myocardial Infarction as Visualized by Cardiac Magnetic Resonance1541Which CMR derived parameter predicts better the need of invasive treatment in aortic coarctation?1543Contrast-enhanced magnetic resonance tomography in patients with supraventricular tachyarrhythmias1546Prognostic Value of CMR Imaging Biomarkers on Outcome in Peripheral Arterial Disease: a 6-year Follow-up Pilot Study1549Dobutamine-Stress-CMR in Young Adults after Arterial Switch Operation as Neonates1553Impact of posteromedial papillary muscle infarction on mitral regurgitation after ST-segment elevation myocardial infarction1556Role of cardiac magnetic resonance imaging in assessment of left ventricular hypertrophy1569Using intrinsic Cardiac Shear Waves to measure Myocardial Stiffness: Preliminary results from Patients with Heart failure with preserved Ejection Fraction1571Relationship of cerebrovascular reactivity and MRI pattern of carotid atherosclerotic plaque1577Feasibility study of an MR conditional pedal ergometer for cardiac stress MRI–preliminary results in healthy volunteers and patients with suspected coronary artery disease1581Pulmonary valve replacement for severe pulmonary stenosis has a positive effect on left ventricular remodeling1582The RV after cardiac surgery, more resilient than thought: multiparametric quantification shows altered rather than reduced function1584Usefulness of cardiovascular magnetic resonance to differentate coronary artery disease from non ischemic cardiomyoptathy in patients with heart failure1593What does CMR add to the ESC Risk Prediction Model to Assess the Occurrence of Sudden Cardiac Death in Patients with HCM?1597Detecting Progression of Diffuse Interstitial Fibrosis in Alstrom Syndrome1612Diffuse fibrosis in the ventricles of patients with transposition of great arteries late after atrial switch1631Utility of Cardiac Magnetic Resonance in the diagnosis and stratification of arrhythmic risk in patients with confirmed or suspected ventricular arrhythmias1635Size matters: pulmonary veins geometry by cardiac magnetic resonance imaging in atrial fibrillation patients1642How do the differences in Left Ventricular wall measurements from Echocardiography and CMR in patients with Hypertrophic Cardiomyopathy affect current Sudden Cardiac Death Risk Scores?1651Noninvasive assessment of intracardiac viscous energy loss in Fontan patients from 4D Flow CMR1653Behcet and Myocardial Infarction: A Rare Combination1328Impact of New Cerebral Ischemic Lesions On the Occurrence of Delirium after Transcatheter Aortic Valve Implantation1329Heart T2* assessment to measure iron overload using different software tools in patients with Thalassemia Major1332Hypertrabeculated Left Ventricle at Cardiac Magnetic Resonance Imaging: β-Thalassemia Major vs. Left Ventricular Non -Compaction Disease1335Aortic Regurgitation following Transcatheter Aortic Valve Implantation (TAVI): a CMR Study of two prosthesis designs1336Incremental value of semi-quantitative evaluation of myocardium perfusion with 3T stress cardiac MRI1343Left ventricular morphological quantification with single shot and free-breathing SSFP cine imaging compared with standard breath-hold SSFP cine imaging1344Changes of cardiac iron and function during pregnancy in transfusion-dependent thalassemia patients1346Significant improvement of survival by T2* MRI in thalassemia major1350The impact of trans-catheter aortic valve implantation induced left-bundle branch block on cardiac reverse remodelling1351Value of magnetic resonance myocardial perfusion imaging in patients with indeterminate coronary computed tomography angiography results1353Gender differences in response to Transcatheter Aortic Valve implantation in patients with severe aortic stenosis assessed by feature tracking1354A qualitative assessment of first-pass perfusion bolus timings in the assessment of myocardial ischemia: A magnetic resonance study1355MRI prospective survey on cardiac iron and function and on hepatic iron in non transfusion-dependent thalassemia intermedia patients treated with desferrioxamine or non chelated1358Coronary Calcification Compromises Myocardial Perfusion Irrespective of Luminal Stenosis1359Non–contrast three–dimensional magnetic resonance imaging for pre–procedural assessment of aortic annulus dimensions in patients undergoing transcatheter aortic valve implantation1360“Systolic ventricularization” of the left atrium with bileaflet mitral valve prolapse: impact on quantification of mitral regurgitation1361CMR assessment of left ventricular remodeling 6 months after percutaneous edge-to-edge repair using Mitraclip1363Accuracy of Transthoracic Echocardiography (TTE) in comparison with Cardiac Magnetic Resonance (CMR)1374CMR for myocardial iron overload assessment: a new calibration curve from the MIOT project1381Can Speckle Tracking Imaging Reveal Myocardial Iron Overload in Thalassemia Major? A Combined Echocardiography and Cardiac Magnetic Resonance Study1382Native myocardial T1 mapping in patients with pulmonary hypertension and age matched volunteers1384A Insidious Line Between Thalassemia Intermedia And Left Ventricular Non-Compaction Disease: The Role Of Cardiac Magnetic Resonance1388Pulmonary Artery : Ascending Aorta Diameter - An Important and Easily Measureable Prognostic Parameter1394Novel carotid artery ultrasound index–Extra-media thickness and a well-established cardiac magnetic resonance fat quantification method1403Validation of CMR-derived LVOT diameters against direct in-vivo measurements1409Early myocardial perfusion measured by CMR in acute myocardial infarction treated by primary PCI–a postconditioning study1420Assessment of paravalvular aortic regurgitation after transcatheter aortic valve implantation using cardiac magnetic resonance imaging: a comparative study with echocardiography and angiography1422Left atrial strain measured by feature tracking predicts left ventricular end diastolic filling pressure1426Validation of extracellular volume equation by serial cardiac magnetic resonance imaging measurements in patients with varying hematocrit1427Assessing diastolic function applying Cardiovascular Magnetic Resonance - comparison with the gold standard1475Role of Adenosine Stress Cardiac Mri in the Setting of Chronic Total Occlusion of Coronary Arteries1520Aortic Elasticity Indexes by Magnetic Resonance Predict Progression of Ascending Aorta Dilation1522Combined atrioventricular assessment of diastolic function by cardiac magnetic resonance1537Safety, image quality and clinical utility of cardiac magnetic resonance in patients with antiarrhythmic devices1538Usefulness of cardiac magnetic resonance to predict the need for surgical procedures in patients with mitral regurgitation1550Normal T1, T2, T2* and extracellular volume reference values in healthy volunteers at 3 Tesla cardiac magnetic resonance1551Comprehensive intra-ventricular myocardial deformation strain analysis in healthy volunteers: implications for regional myocardial disease processes1557Elastic properties changes of aorta in patients with dilatation of the ascending aorta evaluated by Magnetic Resonance1558The prevalence of active myocarditis assessed by cardiovascular magnetic resonance in patients with clinically suspected myocarditis1563Quantitative assessment of myocardial scar heterogeneity using texture analysis to risk stratify post–MI patients for ICD insertion1564Gender differences in exercise capacity and LV remodeling in response to pressure overload in aortic stenosis1572Myocardial wall stress as a novel CMR measure to assess cardiac function1573Feature tracking cardiac magnetic resonance to assess LV mechanics in pressure and volume overload1574Safety, feasibility and clinical impact of Cardiovascular Magnetic Resonance in patients with MR-conditional devices1576T1 Mapping at 1-Year Following Aortic Valve Replacement: Baseline Geometry Defines Magnitude of Fibrosis Regression1583Normal values of LV global myocardial mechanics using two and three-dimensional cardiovascular magnetic resonance1585Prediction of infarct transmurality in acute myocardial infarction based on cardiac magnetic resonance deformation analysis1595Measuring invasive blood pressure by catheters guided solely by Cardiovascular Magnetic Resonance by using a new guidewire without the need of a hybrid CMR-fluoroscopy suite1599Influence of active and passive cardiac implants on CMR image quality: results from a consecutive patient series1600Reproducibility of aortic 4D flow measurements in healthy volunteers1601An automatic approach to extract 4D flow hemodynamic markers: application in BAV-affected patients1602Global myocardial mechanics with 2 and 3-Dimensional cardiovascular magnetic resonance feature tracking in patients with myocarditis1603A CMR-based clinician-friendly assessment of in vivo left ventricle hemodynamics1604Reproducibility of left atrial strain using cardiovascular magnetic resonance myocardial feature tracking1605The severity of myocardial infarction in STEMI, determined by transmurality of infarct and infarct characteristics, impacts on myocardial T2 values1606MicroRNA as potential biomarkers of acute myocardial damage following STEMI1607Myocardial blush grade is associated with microvascular obstruction on CMR following STEMI16084D Flow CMR imaging: Comparison of conventional parallel imaging and variable density k-t acceleration1609In-vitro comparison of segmented-gradient-echo versus non-segmented echo planar imaging 4D Flow CMR: validation of flow volume and 3D vortex ring assessment1614Not just 2D but also 4D flow measurements in pulsatile phantom are accurate and reproducible1615Diffusion Tensor Imaging: Comparison of Hypertrophic Cardiomyopathy, Hypertension and Healthy Cohorts1624Impact of myocardial fibrosis measured by cardiac magnetic resonance imaging on reverse left ventricular remodelling after transcatheter aortic valve implantation1625Prosthetic valve regurgitation after transcatheter aortic valve implantation with new-generation devices compared to surgical aortic valve replacement–a cardiac magnetic resonance imaging flow measurement analysis1637Assessment of Aortic and Pulmonary Artery stiffness in Patients with COPD using Cardiac Magnetic Resonance1638Myocardial Mechanics implications using 2D Cardiovascular Magnetic Resonance in Aortic Regurgitation1639Delineation of myocardial infarction & viability by 12 lead ECG vs cardiac magnetic resonance1641Regional variation in native T1 values in normal healthy volunteers?1645Feasibility of myocardial strain assessment using tissue tracking at 3.0T CMR following ST-segment elevation myocardial infarction1648Diagnostic Impact of Cardiac Magnetic Resonance in patients with acute chest pain, troponin elevation and no significant angiographic coronary artery disease

Author

Lapinskas, Tomas, primary, Elisabetta, Chiodi, primary, Grigoratos, Chrysanthos, primary, Ladeiras-Lopes, Ricardo, primary, Fent, GJ., primary, Abdul Rahman, E., primary, Rodrigues, Jonathan, primary, Gibelli, Giuseppe, primary, Mkrtchyan, Naira, primary, Valinoti, Maddalena, primary, Nyktari, E., primary, Reindl, Martin, primary, Arnhold, K., primary, Lakhani, Zeeshan S. A., primary, Weir-McCall, Jonathan, primary, Camaioni, Claudia, primary, Kan, Rachel, primary, Reinstadler, Sebastian J., primary, Feistritzer, Hans-Josef, primary, Festa, P., primary, Ali, L. Ait, primary, Martínez, A. Tercero, primary, Erdei, Tamas, primary, Orii, Makoto, primary, Sousa, Alexandra, primary, Brzozowska-Czarnek, Agata, primary, Agudo-Quílez, P., primary, Carrabba, Nazario, primary, Almeida-Morais, Luís, primary, Bica, R., primary, Rajewska-Tabor, J., primary, Shaheen, Sameh Mohamed, primary, Inage, Akio, primary, TEIS, Albert, primary, Cescau, Arthur, primary, Cipriani, Alberto, primary, von Roeder, M., primary, Mahmoud, Ahmad A., primary, Duca, Franz, primary, She, Hoi Lam, primary, Burkhardt, B.E.U., primary, Bainbridge, G., primary, Charalambos, Max, primary, Muñoz, Begoña Igual, primary, Contaldi, Carla, primary, Muñoz, B. Igual, primary, Mochula, O.V., primary, van den Bosch, Harrie CM., primary, Frick, M., primary, Gert, Klug, primary, Fawal, aSara E., primary, Webb, Jessica, primary, Maksimova, A.S., primary, Mayr, Agnes, primary, Winter, M.M., primary, Katia, Menacho, primary, Sztajzel, Juan, primary, Papavassiliu, Theano, primary, Baig, S., primary, Shehu, N., primary, Pais, João, primary, Vinco, Giulia, primary, Kamphuis, Vivian P., primary, Bensaoud, M., primary, Abawi, Masieh, primary, Musa, TA., primary, Yun, Chun-Ho, primary, Richmond, C., primary, Meloni, Antonella, primary, Dobson, LE., primary, Schneeweis, C., primary, Foley, JRJ., primary, Matthew, S., primary, Meloni, A., primary, Henein, Michael Y., primary, Barbanti, Marco, primary, Vincenti, Gabriella, primary, Paelinck, Bernard P., primary, Leone, D., primary, Pizzino, F., primary, Saunders, Laura, primary, Macaione, F., primary, Kammerlander, Andreas A., primary, Haberka, Maciej, primary, Aslam, Sajid, primary, Bethke, Anne, primary, Bouhzam, Najime, primary, Heck, Siri Lagethon, primary, Kermer, J., primary, Malanchini, Giovanni, primary, Aquaro, Giovanni Donato, primary, Aquaro, G.D., primary, Igual-Muñoz, Begoña, primary, Igual, Begoña, primary, Roy, Clotilde, primary, Scatteia, Alessandra, primary, Katulska, Katarzyna, primary, Brzostowicz, Tomasz, primary, Gibbs, TGJ, primary, Singh, Anvesha, primary, Le, Thu-Thao, primary, Baritussio, A., primary, Treibel, TA., primary, Hinojar, R., primary, Valente, F., primary, Fratz, Sohrab, primary, Hilbert, Sebastian, primary, van der Palen, RLF., primary, Piatti, Filippo, primary, Berlot, B., primary, Baggi, Chiara, primary, McAlindon, Elisa, primary, Tanaka, Kaoru, primary, Elbaz, Mohammed S.M., primary, Solana, Ana Beatriz, primary, McGill, Laura-Ann, primary, Merten, Constanze, primary, De Garate, Estefania, primary, Salinas, GL. Alonso, primary, Dastidar, Amardeep Ghosh, primary, Nazir, Sheraz A., primary, Bucius, Paulius, additional, Fedaravicius, Augustinas P., additional, Urbonaite, Laura, additional, Stabinskaite, Agnieta, additional, Zaliunas, Remigijus, additional, Teresa, Cannizzaro Maria, additional, Daniele, De Falco Alfano, additional, Righi, Riccardo, additional, Zerbini, Michela, additional, Vincenzo, Positano, additional, Cittanti, Corrado, additional, Giganti, Melchiore, additional, Giorgio, Benea, additional, Genovesi, Dario, additional, Giorgetti, Assuero, additional, Chiappino, Sara, additional, Barison, Andrea, additional, Vergaro, Giuseppe, additional, Todiere, Giancarlo, additional, Emdin, Michele, additional, Marzullo, Paolo, additional, Aquaro, Giovanni Donato, additional, Turin-Moreira, Henrique, additional, Bettencourt, Nuno, additional, Fontes-Carvalho, Ricardo, additional, Sampaio, Francisco, additional, Ambale-Venkatesh, Bharath, additional, Wu, Colin, additional, Liu, Kiang, additional, Bertoni, Alain, additional, Ouyang, Pamela, additional, Bluemke, David, additional, Lima, João, additional, Garg, P., additional, Dobson, LE., additional, Musa, TA., additional, Foley, JF., additional, Haaf, P., additional, Greenwood, JP., additional, Plein, S., additional, Swoboda, PP., additional, Ismail, JR., additional, Najme Khir, R., additional, Lim, CW., additional, Chua, N., additional, Ibrahim, ZO., additional, Zainal Abidin, HA., additional, Mohd Arshad, MK., additional, Kasim, SS., additional, Rooms, Ben, additional, Hyde, Katie, additional, Rohan, Stephen, additional, Dastidar, Amardeep Ghosh, additional, Hamilton, Mark, additional, Bucciarelli‐Ducci, Chiara, additional, Nightingale, Angus, additional, Paton, Julian, additional, Manghat, Nathan, additional, MacIver, David, additional, Demolli, Walter, additional, Russo, Alessandra, additional, Minoia, Chiara, additional, Biasi, Salvatore, additional, Eltschkner, Christin, additional, Christian, Meierhofer, additional, Ewert, Peter, additional, Martinoff, Stefan, additional, Stern, Heiko, additional, Fratz, Sohrab, additional, Fabbri, Claudio, additional, Mantovan, Roberto, additional, Severi, Stefano, additional, Corsi, Cristiana, additional, Vassiliou, V., additional, Arzanauskaite, M., additional, Izgi, C., additional, Lam, W., additional, Prasad, S., additional, Reinstadler, Sebastian Johannes, additional, Feistritzer, Hans-Josef, additional, Klug, Gert, additional, Mair, Johannes, additional, Mayr, Agnes, additional, Jaschke, Werner, additional, Franz, Wolfgang-Michael, additional, Metzler, Bernhard, additional, Muehlberg, F., additional, Fritschi, S., additional, Funk, S., additional, Prothmann, M., additional, von Knobelsdorff-Brenkenhoff, F., additional, Schulz-Menger, J., additional, Mohan, B., additional, karthik, G A., additional, Raj, Vimal, additional, Cassidy, Deirdre B, additional, Belch, Jill JF, additional, Gandy, Stephen J, additional, Houston, Graeme, additional, Lambert, Matthew A, additional, Littleford, Roberta, additional, Rowland, Janice, additional, Struthers, Allan D, additional, Khan, Faisel, additional, Salel, Marjorie, additional, Hennig, Alexia, additional, Corneloup, Olivier, additional, Montaudon, Michel, additional, Laurent, François, additional, Cochet, Hubert, additional, Erhayiem, Bara, additional, McDiarmid, Adam K., additional, Garg, Pankaj, additional, Dobson, Laura E., additional, Musa, Tarique A., additional, Ripley, David, additional, Ajjan, Ramzi, additional, Greenwood, John P., additional, Plein, Sven, additional, Swoboda, Peter P., additional, Fuernau, Georg, additional, Eitel, Charlotte, additional, de Waha, Suzanne, additional, Desch, Steffen, additional, Schuler, Gerhard, additional, Thiele, Holger, additional, Eitel, Ingo, additional, Reindl, Martin, additional, Cadoni, A., additional, D'andrea, C., additional, Costa, S., additional, Keilberg, P., additional, Lunardini, A., additional, Ali, L. Ait, additional, Aquaro, GD., additional, Peritore, G., additional, Ricci, F., additional, De Marchi, D., additional, Passino, C., additional, Festa, P., additional, Cuartero, J. Navarro, additional, Soriano, J.G. Córdoba, additional, Núñez, S. Calero, additional, de Galarreta, T. Cros Ruiz, additional, García, M. Villar, additional, Page, J.C. Gallego, additional, López, J.C. García, additional, Ruiz, M. Barambio, additional, Rodrigues, Jonathan C., additional, McIntyre, Bethannie, additional, Burchell, Amy E., additional, Ratcliffe, Laura, additional, Hart, Emma C., additional, Paton, Julian F., additional, Nightingale, Angus K., additional, Manghat, Nathan E., additional, Tanimoto, Takashi, additional, Ota, Shingo, additional, Nishiguchi, Tsuyoshi, additional, Tsujioka, Hiroto, additional, Kuroi, Akio, additional, Yamano, Takashi, additional, Matsuo, Yoshiki, additional, Ino, Yasushi, additional, Kitabata, Hironori, additional, Kubo, Takashi, additional, Tanaka, Atsushi, additional, Hozumi, Takeshi, additional, Akasaka, Takashi, additional, Pinho, Teresa, additional, Canedo, Paulo, additional, Lopes, Luís, additional, Azevedo, Olga, additional, Madureira, António, additional, Belo, Adriana, additional, Cardoso, José Silva, additional, Machado, José Carlos, additional, Martins, Elisabete, additional, Urbanik, Andrzej, additional, Rakowski, Tomasz, additional, Pozo-Osinalde, E., additional, Viliani, D., additional, Olivera, MJ., additional, Caballero, P., additional, Jiménez-Borreguero, LJ., additional, Alfonso, F., additional, Angeloni, Giulia, additional, Migliorini, Angela, additional, Valenti, Renato, additional, Parodi, Guido, additional, Antoniucci, David, additional, Galrinho, Ana, additional, Moura-Branco, Luísa, additional, Tavares-Jalles, Nuno, additional, António, Marta, additional, Abreu, João, additional, Timóteo, Ana Teresa, additional, Pinto-Teixeira, Pedro, additional, Aguiar-Rosa, Sílvia, additional, Rodrigues, Inês, additional, Modas-Daniel, Pedro, additional, Cruz-Ferreira, Rui, additional, Dobre, D., additional, Stanciu, S., additional, Acatrinei, E., additional, Nour, A., additional, Stefan, L., additional, Calistru, P., additional, Pyda, M., additional, Janus, M., additional, Siniawski, A., additional, Elhammady, Walid Abdel-Azim, additional, Ahmed, Mohamed Ismail, additional, Abdel-Hakim, Ahmed Samir, additional, Allam, Lamyaa Elsayed, additional, Helal, Ayman Mohamed, additional, Mizuno, Naokazu, additional, JUNCÀ, Gladys, additional, ARCE, Javier, additional, ARMARIO, David, additional, Logeart, Damien, additional, Gelen, Barnabas, additional, Derumeaux, Genevie`ve, additional, Vicaut, Eric, additional, Mercadier, Jean-Jacques, additional, Sirol, Marc, additional, De Lazzari, Manuel, additional, Susana, Angela, additional, Zorzi, Alessandro, additional, Baritussio, Anna, additional, Siciliano, Mariachiara, additional, Marinato, Martina, additional, Prevedello, Francesca, additional, Giorgi, Benedetta, additional, Vezzaro, Roberto, additional, Corrado, Domenico, additional, Marra, Martina Perazzolo, additional, Rommel, K.-P., additional, Kowallick, J.T., additional, Blazek, S., additional, Fengler, K., additional, Lotz, J., additional, Hasenfuß, G., additional, Lücke, Ch., additional, Gutberlet, M., additional, Schuler, G., additional, Schuster, A., additional, Lurz, Ph., additional, Rifaie, Osama, additional, Samir, Ahmed, additional, Allam, Lamyaa, additional, Kammerlander, Andreas A., additional, Zotter-Tufaro, Caroline, additional, Aschauer, Stefan, additional, Bonderman, Diana, additional, Mascherbauer, Julia, additional, Roest, Arno A.W., additional, van den Boogaard, Pieter J., additional, Calkoen, Emmeline E., additional, van der Geest, Rob J., additional, Hazekamp, Mark G., additional, de Roos, Albert, additional, Westenberg, Jos J.M., additional, Kellenberger, C.J., additional, Geiger, J., additional, Ruecker, B., additional, Buechel, E.R. Valsangiacomo, additional, Foley, J.R.J., additional, Fent, G., additional, Musa, T.A., additional, Dobson, L., additional, Swoboda, P.P., additional, Greenwood, J.P., additional, Rodrigues, Jonathan, additional, Burchell, Amy, additional, BSc(Hons), Laura Ratcliffe, additional, Hart, Emma, additional, Monserrat, Adrian, additional, gonzalez, Alicia Maceira, additional, Tuset, Luis, additional, Miro, Vicente, additional, Hernandiz, Amparo, additional, Fernandez, Rubén, additional, Sauri, Asunción, additional, Sepúlveda, Pilar, additional, Diez, Jose Luis, additional, Montero, Anastasio, additional, Imbriaco, Massimo, additional, Alcidi, Gianmarco, additional, Ponsiglione, Andrea, additional, Santoro, Ciro, additional, Puglia, Marta, additional, Barbuto, Luigi, additional, Cuocolo, Alberto, additional, Trimarco, Bruno, additional, Galderisi, Maurizio, additional, Sanchez, Elena, additional, Plaza, Diego, additional, sanchis, Pilar Sepúlveda, additional, Gonzalez, Alicia Maceira, additional, vazquez, Alex, additional, Martinez, Luis, additional, Alfredo, Hernandez Caballero, additional, Diana, Domingo Valero, additional, Alicia, Maceira Gonzalez, additional, Jordi, Estornell Erill, additional, Jose, Valera martinez Francisco, additional, Alejandro, Vazquez Sanchez, additional, Anastasio, Montero Argudo, additional, Shelkovnikova, T.A., additional, Popov, S.V., additional, Lukyanenok, P.I., additional, Shelupanov, A.A., additional, Oferkin, A.I., additional, Bakhmet'eva, T.A., additional, Ussov, W.Yu., additional, Westenberg, Jos JM., additional, Setz-Pels, Wikke, additional, Kersten, Erik, additional, Tielbeek, Alexander, additional, Duijm, Lucien EM., additional, Post, Johannes, additional, Teijink, Joep A.W., additional, Kirschfink, A., additional, Mühler, E., additional, Marx, N., additional, Hövels-Gürich, H., additional, Hans-Josef, Feistritzer, additional, Sebastian, Reinstadler, additional, Martin, Reindl, additional, Benjamin, Seidner, additional, Agnes, Mayr, additional, Sylvana, Müller, additional, Bernhard, Metzler, additional, Zidan, aMamdouh, additional, Holub, Ondrej, additional, Clough, Rachel, additional, Carr-White, Gerald, additional, Razavi, Reza, additional, Sinkus, Ralph, additional, Bobrikova, E.E., additional, Bukhovets, I.L., additional, Plotnikov, M.P., additional, Rogovskaya, Yu.V., additional, Rebenkova, M.S., additional, Usov, W.Yu., additional, Kremser, Christian, additional, Schocke, Michael, additional, Pluchinotta, F.R., additional, Giusti, G., additional, Secchi, F., additional, Piazza, L., additional, Carminati, M., additional, Chessa, M., additional, Bokma, J.P., additional, Bouma, B.J., additional, Mulder, B.J., additional, Lombardi, M., additional, Thomas, Treibel, additional, Rebecca, Kozor, additional, Heeraj, Bulluck, additional, James, Moon, additional, Charlotte, Manisty, additional, Bertron, Fabienne, additional, Oezkan, Sueheyla, additional, Lossnitzer, Dirk, additional, Schoenberg, Stefan O., additional, Borggrefe, Martin, additional, Doesch, Christina, additional, Edwards, NC., additional, Liu, B., additional, Hayer, MK., additional, Dawson, CH., additional, Geberhiwot, T., additional, Steeds, RP., additional, Stern, H., additional, Mkrtchyan, N., additional, Meierhofer, C., additional, Martinoff, S., additional, Ewert, P., additional, Fratz, S., additional, Piçarra, Bruno, additional, Santos, Ana Rita, additional, Guerreiro, Rui, additional, Congo, Kisa Hyde, additional, Carvalho, João, additional, Neves, David, additional, Aguiar, José, additional, Fischer, Kady, additional, Labelle, Chantal, additional, Gelineau, Sylvie, additional, Farkas, Sandra, additional, Lebel, Julie, additional, Friedrich, Matthias G., additional, Villa, Adriana, additional, Bekri, Imane, additional, Shome, Joy, additional, Teall, Tom, additional, Di Giovine, Gabriella, additional, Sammut, Eva, additional, Al-Fakih, Khaled, additional, Chiribiri, Amedeo, additional, Roest, Arno AW., additional, Kroft, Lucia JM., additional, Blom, Nico A., additional, Elbaz, Mohammed SM., additional, Soufiani, A., additional, Barahioui, H., additional, Bayi, A., additional, Fellat, N., additional, Benjelloun, H., additional, Tazi, Z., additional, Uddin, A., additional, Swoboa, PP., additional, Fent, GJ., additional, Foley, JRJ., additional, Malkin, CJ., additional, Blackman, DJ., additional, Bezerra, Hiram G., additional, Gamberini, Maria Rita, additional, Neri, Maria Giovanna, additional, Cuccia, Liana, additional, D'Ascola, Domenico Giuseppe, additional, Tudisca, Chiara, additional, Vinci, Valentina, additional, Positano, Vincenzo, additional, Pepe, Alessia, additional, Borgna-Pignatti, Caterina, additional, Del Vecchio, Giovanni Carlo, additional, Romeo, Maria Antonietta, additional, Bonetti, Federico, additional, Missere, Massimiliano, additional, Salvatori, Cristina, additional, Fairbairn, TA., additional, Bebb, OJ., additional, Foley, J., additional, Eckert, J., additional, Tröbs, M., additional, Magedanz, A., additional, Schmidt, M., additional, Voigtländer, T., additional, Schmermund, A., additional, Achenbach, S., additional, Fent, GF., additional, McCall, J. Weir, additional, Gandy, S.J., additional, Milne, W.G., additional, Houston, J.G, additional, Ricchi, P., additional, Spasiano, A., additional, Neri, MG., additional, Vallone, A., additional, Resta, MC., additional, Righi, R., additional, Santamaria, V., additional, Positano, V., additional, Pepe, A., additional, Bengrid, Tarek, additional, Nicoll, Rachel, additional, Zhao, Ying, additional, Johansson, Bengt, additional, Schmermund, Axel, additional, Cascone, Irene, additional, Miccichè, Eligio, additional, Buccheri, Sergio, additional, Immè, Sebastiano, additional, Pilato, Gerlando, additional, Tamburino, Claudia, additional, Patanè, Martina, additional, Gulino, Simona, additional, Todaro, Denise, additional, Salerno, Tatiana, additional, Garretto, Valeria, additional, Privitera, Gianbattista, additional, Capodanno, Davide, additional, Tamburino, Corrado, additional, Manna, Alessio La, additional, Masci, Pier-Giorgio, additional, Rutz, Tobias, additional, De Blois, Jonathan, additional, Schwitter, Juerg, additional, Monney, Pierre, additional, Vandendriessche, Tom, additional, De Bock, Dina, additional, Parizel, Paul M., additional, Rodrigus, Inez E., additional, Claeys, Marc J., additional, Tosello, F., additional, Bruno, G., additional, Avenatti, E., additional, Faletti, R., additional, Ravera, A, additional, Veglio, F., additional, Milan, A., additional, Maggio, A., additional, Leto, F., additional, Pitrolo, L., additional, Meloni, A., additional, Terrizzi, A., additional, Serra, M., additional, Allò, M., additional, Di Bella, G., additional, Zito, C., additional, Stewart, Neil J., additional, Hammerton, Charlotte, additional, Capener, David, additional, Puntmann, Valentina O, additional, Graves, Martin J., additional, Kiely, David G., additional, Wild, Jim M., additional, Swift, Andrew J., additional, Barison, A., additional, Salvatore, N., additional, Assennato, P., additional, Marzluf, Beatrice A., additional, Duca, Franz, additional, Knechtelsdorfer, Klaus, additional, Wiesinger, Matthias, additional, Dalos, Daniel, additional, Pfaffenberger, Stefan, additional, Sosnowski, Maciej, additional, Gąsior, Zbigniew, additional, El-Hamamsy, Ismail, additional, SM, François-Pierre Mongeon, additional, Eritsland, Jan, additional, Shanmuganathan, Limalanathan, additional, Abdelnoor, Mikael, additional, Andersen, Geir Øystein, additional, Kløw, Nils Einar, additional, Hoffmann, Pavel, additional, Caudron, Jérôme, additional, Tron, Christophe, additional, Camacho, Carlos Rodriguez, additional, Cribier, Alain, additional, Dacher, Jean Nicolas, additional, Eltchaninoff, Hélène, additional, Gulati, Geeta, additional, Von Knobelsdorff-Brenkenhoff, Florian, additional, Storås, Tryggve Holck, additional, Schulz-Menger, Jeanette, additional, Omland, Torbjørn, additional, Traber, J., additional, Utz, W., additional, Hennig, P., additional, Menza, M., additional, Jung, B., additional, Greiser, A., additional, Kuijer, J., additional, Barckow, P., additional, Töpper, A., additional, Schulz-Menger, J, additional, Moscatelli, Sara, additional, Balzarini, Luca, additional, Del Corral, Maria Pia, additional, Gasparini, Gabriele, additional, Montini, Orsola, additional, Monti, Lorenzo, additional, Briatico, Alessandra, additional, Toia, Patrizia, additional, Ait-Ali, Lamia, additional, Midiri, Massimo, additional, Cotroneo, Antonio Raffaele, additional, Festa, Pierluigi, additional, Pizzino, F., additional, Todiere, G., additional, Grigoratos, C., additional, de Carranza, María Jose Sancho-Tello, additional, Maceira-Gonzalez, Alicia, additional, Buendía-Fuentes, Francisco, additional, Estornell-Erill, Jordi, additional, Cano-Perez, Oscar, additional, Sanz, Jorge, additional, Maceira, Alicia, additional, Minguez, Ana Bel, additional, Guillen, Manuel Perez, additional, Lopez, Raquel, additional, Vazquez, Alex, additional, rené, Oscar, additional, sepúlveda, Pilar, additional, argudo, Anastasio Montero, additional, Slimani, Alisson, additional, Amzulescu, Mihaela, additional, de Ravenstein, Christophe de Meester, additional, Pasquet, Agnès, additional, Vancraeyenest, David, additional, Vanoverschelde, Jean-Louis, additional, Gerber, Bernhard, additional, Pouleur, Anne-Catherine, additional, Lyen, Stephen, additional, De Gerate, Estefania, additional, Pennell, Dudley, additional, Bucciarelli-Ducci, Chiara, additional, Kociemba, Anna, additional, Rajewska-Tabor, Justyna, additional, Janus, Magdalena, additional, Siniawski, Andrzej, additional, Stajgis, Marek, additional, Pyda, Małgorzata, additional, Brzostowicz, Marta, additional, Villa, AD, additional, Sammut, E, additional, Mullen, G, additional, Ganeshan, B, additional, Chiribir, A, additional, McCann, Gerry P, additional, Su, Boyang, additional, Cai, Jiasheng, additional, Han, Yiying, additional, Tan, Ru San, additional, Cook, Stuart A, additional, Chin, Calvin WL, additional, Vollema, E. Mara, additional, Leung, Melissa, additional, Marsan, Nina Ajmone, additional, De Garate, Estefania, additional, Bax, Jeroen J, additional, Delgado, Victoria, additional, De Garate, E., additional, Dastidar, A. Ghosh, additional, Ahmed, N., additional, Scatteia, A., additional, Rodrigues, J., additional, Lawton, C., additional, Thomas, Glyn, additional, Duncan, Edward, additional, Cripps, Tim, additional, Diab, Ihab, additional, Bucciarelli-Ducci, C., additional, Fontana, M., additional, Kozor, R., additional, Macrae, R., additional, Malcolmson, JW., additional, Menacho, KD., additional, Scully, PR., additional, Lawrence, DR., additional, Sheikh, AM., additional, Herrey, AS., additional, Manisty, C., additional, Moon, JC., additional, Golfin, C. Fernandez, additional, Portugal, JC., additional, Esteban, A., additional, Megias, A., additional, Gomez, A. Gonzalez, additional, Rincon, LM., additional, Nacher, JJ. Jimenez, additional, Zamorano, JL., additional, Gutierrez, L., additional, Maldonado, G., additional, Pineda, V., additional, Agliano, B., additional, Galian, L., additional, Teixido, G., additional, Gonzalez-Allujas, MT., additional, Evangelista, A., additional, Garcia-Dorado, D., additional, Rodriguez-Palomares, JF., additional, Belker, Kristina, additional, Naumann, Susanne, additional, Shehu, Nerejda, additional, Mkrtchyan, Naira, additional, Meierhofer, Christian, additional, Eicken, Andreas, additional, Weber, Alexander, additional, Oebel, Sabrina, additional, Hindricks, Gerhard, additional, Jahnke, Cosima, additional, Paetsch, Ingo, additional, Roest, AAW., additional, van den Boogaard, PJ., additional, Blom, NA., additional, de Roos, A., additional, Westenberg, JJM., additional, Sturla, Francesco, additional, Pirola, Selene, additional, Votta, Emiliano, additional, Nesteruk, Igor, additional, Lombardi, Massimo, additional, Corte, Alessandro Della, additional, Bissell, Malenka, additional, Caiani, Enrico Gianluca, additional, Redaelli, Alberto, additional, Hinojar, R., additional, Mendez, MA Fernandez, additional, García, A., additional, Alonso, G., additional, Marco, A., additional, Casas, E., additional, Piatti, Filippo, additional, Pluchinotta, Francesca, additional, Gonzalez Gomez, A., additional, Dastidar, Amardeep, additional, Littlejohns, Ben, additional, Suleiman, Saadeh, additional, Baumbach, Andreas, additional, Vizzi, Vincenzo, additional, Fierens, Yves, additional, Nijs, Jan, additional, De Mey, Johan, additional, Lai, Peng, additional, Raeymaekers, Hubert, additional, Toger, Johannes, additional, Heiberg, Einar, additional, Westenberg, Jos J., additional, Hafalir, Fatih, additional, Ghedin, Piero, additional, Shimakawa, A., additional, Anja, C., additional, Ferreira, Pedro, additional, Scott, Andrew D, additional, Nielles-Vallespin, Sonia, additional, Giannakidis, Archontis, additional, J Kilner, Philip, additional, Gatehouse, Peter D, additional, de Silva, Ranil, additional, Firmin, David N, additional, Pennell, Dudley J, additional, Beurich, Hans-Wilko, additional, Zachow, Dirk, additional, El-Mawardy, Mohamed, additional, Abdel-Wahab, Mohamed, additional, Richardt, Gert, additional, Tölg, Ralph, additional, Biglino, Giovanni, additional, Aileen, Wilson, additional, Dodd, James, additional, Gómez, A. González, additional, Golfín, C. Fernández, additional, del Castillo, A. Marco, additional, Monteagudo, J., additional, Izco, M. Pascual, additional, Megías, A., additional, Martín, A. García, additional, Nacher, JJ. Jiménez, additional, Zamorano, JL, additional, Carpenter, Alexander, additional, Palazzuoli, Alberto, additional, Wilson, Catherine, additional, Kestenbaum, Samantha, additional, Szantho, Gergely, additional, McAlindon, Elisa, additional, Scatteia, Alessandra, additional, Lawton, Chris Benny, additional, Erdei, Tamas, additional, Shetye, Abhishek, additional, Khan, Jamal N., additional, Singh, Anvesha, additional, Kanagala, Prathap, additional, Swarbrick, Daniel, additional, Gulsin, Gaurav, additional, Graham-Brown, Matthew, additional, Gershlick, Anthony, additional, and McCann, Gerry P., additional

Published
2016
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16. Self-reported weight and height: implications for left ventricular hypertrophy detection. An Italian multi-center study

Author

Cuspidi, C., Negri, F., Giudici, V., Muiesan, Maria Lorenza, Grandi, A. M., Ganau, A., Lonati, L., Esposti, D. D., Capra, A., Milan, A., Sala, C., Longo, M., Morganti, A., Working Group on Heart, Hypertension of the Italian Society of Hypertension, Lonati, L, Capra, A, Scanziani, E, Degli Esposti, D, Bacchelli, S, Ganau, A, Oppo, A, Grandi, Am, Nicolini, E, Mongiardi, C, Longo, M, Milan, A, Avenatti, E, Veglio, F, Negri, F, Giudici, V, Valerio, C, Re, A, Cuspidi, C, Muiesan, Ml, Salvetti, Massimo, Paini, Anna, Monteduro, C., Cuspidi, C, Negri, F, Giudici, V, Muiesan, M, Ganau, A, Grandi, A, Lonati, L, Degli Esposti, D, Capra, A, Milan, A, Sala, C, Longo, M, and Morganti, A

Subjects
Adult, Male, medicine.medical_specialty, hypertension, left ventricular hypertrophy, Physiology, Body height, Heart Ventricles, Population, Self reported weight, Body size, Left ventricular hypertrophy, Left ventricular mass, Adult, Age Factors, Aged, Body Height, Body Weight, Female, Heart Ventricles, pathology, Humans, Hypertrophy, Left Ventricular, epidemiology/pathology/ultrasonography, Italy, epidemiology, Male, Middle Aged, Organ Size, Prevalence, Self Report, Sex Factors, Sex Factors, Internal medicine, Internal Medicine, medicine, Prevalence, Humans, education, Ultrasonography, Aged, education.field_of_study, business.industry, Body Weight, Age Factors, General Medicine, Hypertrophy, Organ Size, Anthropometry, Middle Aged, medicine.disease, Body Height, epidemiology/pathology/ultrasonography, Italy, Multi center study, Cardiology, Hypertrophy, Left Ventricular, Female, pathology, epidemiology, Self Report, MED/09 - MEDICINA INTERNA, business
Abstract

We examined the difference between self-reported and measured body size values and their impact on detection of left ventricular hypertrophy (LVH) by echocardiographic LV mass indexation. A total of 1963 subjects referred by their practitioners for routine echocardiographic examination to nine outpatient echocardiographic laboratories across Italy were included in the study. Left ventricular hypertrophy was defined according to two gender-specific criteria as: A) Left ventricular mass (LVM) index ≥49 g/h2.7 in men and ≥45 g/h2.7 in women; B) LVM index ≥125 g/m2 in men and ≥110 g/m2 in women. Prevalence of LVH was calculated by indexing LVM to both self-reported and measured anthropometric values. In the whole population, LVH tended to be underestimated by self-reported values by 5.4% according to criterion A (48.5% vs. 53.9%, p < 0.001) and by 1.2% according to criterion B (29.6% vs. 30.8%, p < 0.01); similar findings were observed in the hypertensive subgroup encompassing one-half of the sample. Underestimation of LVH was more pronounced in older patients than in younger patients: 8.6% vs. 3.2% (p < 0.001) by criterion A, 3.1% vs. 0.1% (p < 0.001) by criterion B, in women than in men (8.6% vs. 3.3% (p < 0.001) by criterion A and 1.8% vs. 0.5% (p < 0.01) by criterion B. In a sample of outpatients attending echocardiographic laboratories, LVH is misclassified when left ventricular mass is normalized to self-reported weight and height. The error is related to the clinical characteristics of patients and is more pronounced when LVM is normalized to height2.7. © 2011 Informa Healthcare USA, Inc.

Published
2011

17. HIT Poster session 2P486The effect of short term aerobic exercise and ACE polymorphism on cardiovascular remodeling in healthy sedentary postmenopausal womenP487Are there predictors of malignant progression of aortic stenosis severity?P488Quantitative und semiquantitative parameters in the classification of aortic insufficiency: a 3D-echocardiography and magnet resonance imaging studyP489Vascular indicies surrogate markers for left ventricular dysfunctionP490Left ventricular systolic strain data does not require indexation to cavity size in mitral valve diseasesP491Impact of EACVI grant programme on career progression of grant winnersP492Early predictor of atrial fibrillation recurrence after electrical cardioversion: diastolic parameters come firstP493Echocardiographic diagnosis of arrhythmias in the fetusP4943D echocardiography is a fast-learning and a more reliable method compared with 2D echocardiography for the assessment of left ventricular volumes and ejection fraction in patients with heart failureP495Right ventricular mechanics in functional ischemic mitral regurgitation in acute inferior myocardial infarctionP496Added value of two dimentional strain in assessement of left ventricular systolic function in rheumatic mitral stenosis patients with normal ejection fractionP497Left ventricular myocardial deformation in arterial hypertension with different types of glucose metabolism disordersP498Epicardial to pericardial adipose tissue ratio: predicting myocardial ischemia in patients referred for exercise stress echocardiographyP499Echocardiographic evaluation of the patients with asd after percutaneous closureP500Screening for carotid artery stenosis with the use of pocket-size imaging device equipped with linear probeP501LAD correlates poorly with LAVIP502Predictors associated with the diastolic dysfunction formation in patients with moderate hypertensionP503Assessment of left atrial function by speckle tracking analysis in transthoracic echocardiography for predicting the presence of left atrial appendage thrombus in patients with atrial fibrillationP504can echocardiography detect subclinical myocardial damage in the layers of myocardial wall? (The first study in a large population with known inflammatory disease)P505Epicardial fat thickness and galectin 3 in patients with atrial fibrillation and metabolic syndromeP506Left ventricular reverse remodeling in heart failure: a new obesity paradox?P507Epicardial adipose tissue and carotid intima media thickness in hemodialysis patients; single center experienceP508Echocardiographic parameters of mitral valve remodeling associated with poor clinical outcome in high risk patients with functional mitral regurgitation after Mitraclip implantationP509Prevalence of valve disease in a community population over the age of 60P510Discordance between mitral valve area and mean transmitral pressure gradient in mitral stenosis: Is mean gradient marker of the severity or parameter of tolerance in severe mitral stenosis?P511Ischemic mitral regurgitation is associated with impaired radial and circumferential myocardial deformation in acute inferoposterior myocardial infarctionP512The importance of early left atrial functional changes in predicting long term left ventricular remodeling in patients surviving a ST elevation myocardial infarctionP513Remodeling of myocardial deformation after mitral valve surgeryP514Global longitudinal peak systolic strain is reduced shortly after heart transplantationP515Detailed transthoracic and transesophageal echocardiographic analysis of mitral leaflets in patient undergoing mitral valve repair

Author

Bucciarelli, V, primary, Avenatti, E, primary, Rosner, SJ, primary, Cherneva, ZHCH, primary, Li, H, primary, Surkova, E A, primary, Degiovanni, A, primary, Ortiz Garrido, A, primary, Mihaila, S, primary, Tamulenaite, E, primary, Amorouayeche, F Z, primary, Kolesnyk, M Y, primary, Garcia Campos, A, primary, Savcioglu, AS, primary, Filipiak, D, primary, Kuusisto, J K, primary, Torbas, O, primary, Kupczynska, K, primary, Tountas, X, primary, Ionin, VA, primary, Cescau, A, primary, Altin, C, primary, Ferreiro Quero, C, primary, Lowery, C, primary, Najih, H, primary, Valuckiene, Z, primary, Onciul, S, primary, Yang, L-T, primary, Baricevic, Z, primary, Ghulam Ali, S, primary, Bianco, F, additional, Izzicupo, P, additional, Ghinassi, B, additional, Di Baldassarre, A, additional, Gallina, S, additional, Milazzo, V, additional, Milan, A, additional, Patel, A, additional, Kuvin, J, additional, Pandian, N, additional, Orban, M, additional, Nadjiri, J, additional, Lesevic, H, additional, Hadamitzky, M, additional, Sonne, C, additional, Kuneva, ZK, additional, Vasilev, DV, additional, Yuan, L, additional, Xie, MX, additional, Jin, XY, additional, Muraru, D, additional, Grapsa, J, additional, Donal, E, additional, Lancellotti, P, additional, Habib, G, additional, Badano, L P, additional, Buffa, MC, additional, De Vecchi, F, additional, Prenna, E, additional, Boggio, E, additional, Marino, P, additional, De La Chica, J, additional, Cuenca Peiro, V, additional, Picazo Angelin, B, additional, Conejo Munoz, L, additional, Narbona, I, additional, Anderica, JR, additional, De Mora, M, additional, Zabala Arguelles, JI, additional, Velcea, A, additional, Matei, L, additional, Andronic, A, additional, Calin, S, additional, Rimbas, R, additional, Badano, LP, additional, Vinereanu, D, additional, Ovsianas, J, additional, Valuckiene, Z, additional, Jurkevicius, R, additional, Latreche, S, additional, Benkhedda, S, additional, Dzyak, G V, additional, Riznyk, Y Y, additional, Kovalyova, O V, additional, Velasco-Alonso, E, additional, Colunga-Blanco, S, additional, Martin-Fernandez, M, additional, Corros-Vicente, C, additional, Rodriguez-Suarez, ML, additional, Leon-Aguero, V, additional, De La Hera Galarza, JM, additional, Safak, O, additional, Nazli, C, additional, Akyildiz Akcay, F, additional, Yakar Tuluce, S, additional, Kahya Eren, N, additional, Ozdemir, E, additional, Kocabas, U, additional, Kasprzak, JD, additional, Lipiec, P, additional, Jarvinen, VM, additional, Sinisalo, JP, additional, Sirenko, YU, additional, Radchenko, G, additional, Rekovets, O, additional, Kushnir, S, additional, Michalski, BW, additional, Miskowiec, D, additional, Wdowiak-Okrojek, K, additional, Wejner-Mik, P, additional, Beldekos, D, additional, Protogerou, A, additional, Gournizakis, A, additional, Panopoulos, S, additional, Theodosis-Georgilas, A, additional, Fousas, S, additional, Sfikakis, P, additional, Soboleva, AV, additional, Listopad, OV, additional, Nifontov, SE, additional, Polyakova, EA, additional, Belyaeva, OD, additional, Baranova, EI, additional, Shlyachto, EV, additional, Baudet, M, additional, Cohen-Solal, A, additional, Logeart, D, additional, Sakallioglu, O, additional, Aydin, E, additional, Yilmaz, M, additional, Sade, LE, additional, Muderrisoglu, H, additional, Mesa Rubio, M D, additional, Ruiz Ortiz, M, additional, Delgado Ortega, M, additional, Sanchez Fernandez, J, additional, Duran Jimenez, E, additional, Morenate Navio, C, additional, Romero, M, additional, Pan, M, additional, Suarez De Lezo, J, additional, Frenneaux, M P, additional, Parasuraman, S K, additional, Rudd, A E, additional, Srinivasan, J, additional, Elbaghdadi, D, additional, Laarej, A, additional, Allouch, M, additional, Azzouzi, L, additional, Habbal, R, additional, Mizariene, V, additional, Ablonskyte-Dudoniene, R, additional, Cucchini, U, additional, Miglioranza, MH, additional, Dorobantu, M, additional, Iliceto, S, additional, Tsai, WC, additional, Cikes, M, additional, Ljubas Macek, J, additional, Skoric, B, additional, Skorak, I, additional, Jurin, H, additional, Samardzic, J, additional, Gasparovic, H, additional, Milicic, D, additional, Separovic Hanzevacki, J, additional, Fusini, L, additional, Tamborini, G, additional, Gripari, P, additional, Muratori, M, additional, Celeste, F, additional, Carminati, MC, additional, Alamanni, F, additional, and Pepi, M, additional

Published
2015
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18. Prevalence and Correlates of Echocardiographic Left Atrial Enlargement in Hypertensive Outpatients in Clinical Practice

Author

Cuspidi, C, Negri, F, Lonati, L, Muiesan, M, Capra, A, Milan, A, Sala, C, Danzi, G, Longo, M, Morganti, A, Bonanomi, C, Settimi, E, Scanziani, E, Giannattasio, C, Trocino, G, Casati, A, Chiappa, L, Paggi, A, Degli Esposti, D, Bacchelli, S, Ganau, A, Oppo, A, Grandi, A, Nicolini, E, Mongiardi, C, Branzi, G, Parati, G, Valerio, C, Marconi, M, Macca, G, Avenatti, E, Veglio, F, Salvetti, M, Paini, A, Galbassini, G, Monteduro, C, Giudici, V, Re, A, Pellizzoli, S, Robustelli, F, Rao, M, Iovino, G, Arcucci, O, De Luca, N, Tocci, G, Ciavarella, M, Volpe, M, Vaccarella, A, Veglia, M, CUSPIDI, CESARE, NEGRI, FRANCESCA, CAPRA, ANNA CLARA MARIA, GIANNATTASIO, CRISTINA, PARATI, GIANFRANCO, Muiesan, ML, Danzi, GB, Grandi, AM, Rao, MA, Iovino, GL, Veglia, MG, Cuspidi, C, Negri, F, Lonati, L, Muiesan, M, Capra, A, Milan, A, Sala, C, Danzi, G, Longo, M, Morganti, A, Bonanomi, C, Settimi, E, Scanziani, E, Giannattasio, C, Trocino, G, Casati, A, Chiappa, L, Paggi, A, Degli Esposti, D, Bacchelli, S, Ganau, A, Oppo, A, Grandi, A, Nicolini, E, Mongiardi, C, Branzi, G, Parati, G, Valerio, C, Marconi, M, Macca, G, Avenatti, E, Veglio, F, Salvetti, M, Paini, A, Galbassini, G, Monteduro, C, Giudici, V, Re, A, Pellizzoli, S, Robustelli, F, Rao, M, Iovino, G, Arcucci, O, De Luca, N, Tocci, G, Ciavarella, M, Volpe, M, Vaccarella, A, Veglia, M, CUSPIDI, CESARE, NEGRI, FRANCESCA, CAPRA, ANNA CLARA MARIA, GIANNATTASIO, CRISTINA, PARATI, GIANFRANCO, Muiesan, ML, Danzi, GB, Grandi, AM, Rao, MA, Iovino, GL, and Veglia, MG

Abstract

Prevalence of left atrial enlargement (LAE) in hypertension has been mostly assessed in population-based samples and selected hypertensive groups. A few data are available in clinical practice. We examined LAE prevalence and severity in a cohort of hypertensive patients referred by general practitioners to a routine echocardiographic examination. A total of 2170 hypertensive individuals (mean age 62 years, 53% men) referred by practitioners to 17 outpatient echocardiographic laboratories across Italy for detection of hypertensive cardiac disease were included in the study. LAE was defined as: A) absolute LA diameter >4.0 cm in men and >3.8 cm in women; B) LA diameter normalized to body surface area (BSA) >2.3 cm/m2 in both sexes. Left atrial enlargement was graded as mild, moderate, and severe according to Lang’s report. Patients with LAE were 38% by criterion A, and 20% by criterion B. A moderate/severe increase in LA size was present in 34% (A) and 32% (B) of patients with LAE. Severe LAE was 3.3-fold (A) and 2.6-fold (B) more frequent in women than in men. Left ventricular mass was the strongest correlate of absolute LA diameter as well as of normalized LA diameter, after age. Left atrial enlargement defined either by absolute or normalized LA diameter is a frequent cardiac phenotype in hypertensive patients referred to echo-labs in clinical practice. This cardiac parameter is closely related to LV mass and its severity is highly prevalent in women.

Published
2011

25. Poster session Wednesday 11 December all day display: 11/12/2013, 09:30-16:00 * Location: Poster area

Author

Bertrand, PB, Grieten, L, Smeets, C, Verbrugge, FH, Mullens, W, Vrolix, M, Rivero-Ayerza, M, Verhaert, D, Vandervoort, P, Tong, L, Ramalli, A, Tortoli, P, Dhoge, J, Bajraktari, G, Lindqvist, P, Henein, MY, Obremska, M, Boratynska, MB, Kurcz, JK, Zysko, DZ, Baran, TB, Klinger, MK, Darahim, K, Mueller, H, Carballo, D, Popova, N, Vallee, J-P, Floria, M, Chistol, R, Tinica, G, Grecu, M, Rodriguez Serrano, M, Osa-Saez, A, Rueda-Soriano, J, Buendia-Fuentes, F, Domingo-Valero, D, Igual-Munoz, B, Alonso-Fernandez, P, Quesada-Carmona, A, Miro-Palau, V, Palencia-Perez, M, Bech-Hanssen, O, Polte, CL, Lagerstrand, K, Janulewicz, M, Gao, S, Erdogan, E, Akkaya, M, Bacaksiz, A, Tasal, A, Sonmez, O, Turfan, M, Kul, S, Vatankulu, MA, Uyarel, H, Goktekin, O, Mincu, RI, Magda, LS, Mihaila, S, Florescu, M, Mihalcea, D, Enescu, OE, Chiru, A, Popescu, B, Tiu, C, Vinereanu, D, 112/2011, Research grant, Broch, K, Kunszt, G, Massey, R, De Marchi, SF, Aakhus, S, Gullestad, L, Urheim, S, Yuan, L, Feng, JL, Jin, XY, Bombardini, T, Casartelli, M, Simon, D, Gaspari, MG, Procaccio, F, Hasselberg, NE, Haugaa, KH, Brunet, A, Kongsgaard, E, Donal, E, Edvardsen, T, Sahin, TAYLAN, Yurdakul, S, Cengiz, BETUL, Bozkurt, AYSEN, Aytekin, SAIDE, Cesana, F, Spano, F, Santambrogio, G, Alloni, M, Vallerio, P, Salvetti, M, Carerj, S, Gaibazzi, N, Rigo, F, Moreo, A, Group, APRES Collaborative, Wdowiak-Okrojek, K, Michalski, B, Kasprzak, JD, Shim, A, Lipiec, P, Generati, G, Pellegrino, M, Bandera, F, Donghi, V, Alfonzetti, E, Guazzi, M, Marcun, R, Stankovic, I, Farkas, J, Vlahovic-Stipac, A, Putnikovic, B, Kadivec, S, Kosnik, M, Neskovic, AN, Lainscak, M, Iliuta, L, Szymanski, P, Lipczynska, M, Klisiewicz, A, Sobieszczanska-Malek, M, Zielinski, T, Hoffman, P, Gjerdalen, G F, Hisdal, J, Solberg, EE, Andersen, TE, Radunovic, Z, Steine, K, Svanadze, A, Poteshkina, N, Krylova, N, Mogutova, P, Shim, A, Kasprzak, JD, Szymczyk, E, Wdowiak-Okrojek, K, Michalski, B, Stefanczyk, L, Lipiec, P, Benedek, T, Matei, C, Jako, B, Suciu, ZS, Benedek, I, Yaroshchuk, N A, Kochmasheva, V V, Dityatev, V P, Kerbikov, O B, Przewlocka-Kosmala, M, Orda, A, Karolko, B, Mysiak, A, Kosmala, W, Rechcinski, T, Wierzbowska-Drabik, K, Lipiec, P, Chmiela, M, Kasprzak, JD, Aziz, A, Hooper, J, Rayasamudra, S, Uppal, H, Asghar, O, Potluri, R, Zaroui, A, Mourali, MS, Rezine, Z, Mbarki, S, Jemaa, M, Aloui, H, Mechmeche, R, Farhati, A, Gripari, P, Maffessanti, F, Tamborini, G, Muratori, M, Fusini, L, Vignati, C, Bartorelli, AL, Alamanni, F, Agostoni, PG, Pepi, M, Ruiz Ortiz, M, Mesa, D, Delgado, M, Seoane, T, Carrasco, F, Martin, M, Mazuelos, F, Suarez De Lezo Herreros De Tejada, J, Romero, M, Suarez De Lezo, J, Brili, S, Stamatopoulos, I, Misailidou, M, Chrisochoou, C, Christoforatou, E, Stefanadis, C, Ruiz Ortiz, M, Mesa, D, Delgado, M, Martin, M, Seoane, T, Carrasco, F, Ojeda, S, Segura, J, Pan, M, Suarez De Lezo, J, Cammalleri, V, Ussia, GP, Muscoli, S, Marchei, M, Sergi, D, Mazzotta, E, Romeo, F, Igual Munoz, B, Bel Minguez, ABM, Perez Guillen, MPG, Maceira Gonzalez, AMG, Monmeneu Menadas, JVMM, Hernandez Acuna, CHA, Estornell Erill, JEE, Lopez Lereu, PLL, Francisco Jose Valera Martinez, FJVM, Montero Argudo, AMA, Sunbul, M, Akhundova, A, Sari, I, Erdogan, O, Mutlu, B, Cacicedo, A, Velasco Del Castillo, S, Anton Ladislao, A, Aguirre Larracoechea, U, Rodriguez Sanchez, I, Subinas Elorriaga, A, Oria Gonzalez, G, Onaindia Gandarias, J, Laraudogoitia Zaldumbide, E, Lekuona Goya, I, Ding, W, Zhao, Y, Lindqvist, P, Nilson, J, Winter, R, Holmgren, A, Ruck, A, Henein, MY, Attenhofer Jost, C H, Soyka, R, Oxenius, A, Kretschmar, O, Valsangiacomo Buechel, ER, Greutmann, M, Weber, R, Keramida, K, Kouris, N, Kostopoulos, V, Karidas, V, Damaskos, D, Makavos, G, Paraskevopoulos, K, Olympios, CD, Eskesen, K, Olsen, NT, Fritz-Hansen, T, Sogaard, P, Cameli, M, Lisi, M, Righini, FM, Curci, V, Massoni, A, Natali, B, Maccherini, M, Chiavarelli, M, Massetti, M, Mondillo, S, Mabrouk Salem Omar, A, Ahmed Abdel-Rahman, M, Khorshid, H, Rifaie, O, Santoro, C, Santoro, A, Ippolito, R, De Palma, D, De Stefano, F, Muscariiello, R, Galderisi, M, Squeri, A, Censi, S, Baldelli, M, Grattoni, C, Cremonesi, A, Bosi, S, Saura Espin, D, Gonzalez Canovas, C, Gonzalez Carrillo, J, Oliva Sandoval, MJ, Caballero Jimenez, L, Espinosa Garcia, MD, Garcia Navarro, M, Valdes Chavarri, M, De La Morena Valenzuela, G, Ryu, SK, Shin, DG, Son, JW, Choi, JH, Goh, CW, Choi, JW, Park, JY, Hong, GR, Sklyanna, O, Yuan, L, Yuan, L, Planinc, I, Bagadur, G, Ljubas, J, Baricevic, Z, Skoric, B, Velagic, V, Bijnens, B, Milicic, D, Cikes, M, Gospodinova, M, Chamova, T, Guergueltcheva, V, Ivanova, R, Tournev, I, Denchev, S, Ancona, R, Comenale Pinto, S, Caso, P, Arenga, F, Coppola, MG, Calabro, R, Neametalla, H, Boitard, S, Hamdi, H, Planat-Benard, V, Casteilla, L, Li, Z, Hagege, AA, Mericskay, M, Menasche, P, Agbulut, O, Merlo, M, Stolfo, D, Anzini, M, Negri, F, Pinamonti, B, Barbati, G, Di Lenarda, A, Sinagra, G, Stolfo, D, Merlo, M, Pinamonti, B, Gigli, M, Poli, S, Porto, A, Di Nora, C, Barbati, G, Di Lenarda, A, Sinagra, G, Coppola, C, Piscopo, G, Cipresso, C, Rea, D, Maurea, C, Esposito, E, Arra, C, Maurea, N, Nemes, A, Kalapos, A, Domsik, P, Forster, T, Voilliot, D, Huttin, O, Vaugrenard, T, Schwartz, J, Sellal, J-M, Aliot, E, Juilliere, Y, Selton-Suty, C, Sanchez Millan, P J, Cabeza Lainez, P, Castillo Ortiz, J, Chueca Gonzalez, EM, Gheorghe, L, Fernandez Garcia, P, Herruzo Rojas, MS, Del Pozo Contreras, R, Fernandez Garcia, M, Vazquez Garcia, R, Rosca, M, Popescu, BA, Botezatu, D, Calin, A, Beladan, CC, Gurzun, M, Enache, R, Ginghina, C, Farouk, H, Al-Maimoony, T, Alhadad, A, El Serafi, M, Abdel Ghany, M, Poorzand, H, Mirfeizi, SZ, Javanbakht, A, center, Preventive Cardiovascular care research, center, Lupus Research, sciences, Mashhad university of medical, Tellatin, S, Famoso, G, Dassie, F, Martini, C, Osto, E, Maffei, P, Iliceto, S, Tona, F, Radunovic, Z, Steine, KS, Jedrzejewska, I, Braksator, W, Krol, W, Swiatowiec, A, Sawicki, J, Kostarska-Srokosz, E, Dluzniewski, M, Maceira Gonzalez, A M, Cosin-Sales, J, Diago, JL, Aguilar, J, Ruvira, J, Monmeneu, J, Igual, B, Lopez-Lereu, MP, Estornell, J, Olszanecka, A, Dragan, A, Kawecka-Jaszcz, K, Czarnecka, D, Scholz, F, Gaudron, PD, Hu, K, Liu, D, Florescu, C, Herrmann, S, Bijnens, B, Ertl, G, Stoerk, S, Weidemann, F, Krestjyaninov, M, Razin, VA, Gimaev, RH, Bogdanovic, Z, Burazor, I, Deljanin Ilic, M, Peluso, D, Muraru, D, Cucchini, U, Mihaila, S, Casablanca, S, Pigatto, E, Cozzi, F, Punzi, L, Badano, LP, Iliceto, S, Zhdanova, E, Rameev, VV, Safarova, AF, Moisseyev, SV, Kobalava, ZD, Magnino, C, Omede, P, Avenatti, E, Presutti, D, Losano, I, Moretti, C, Bucca, C, Gaita, F, Veglio, F, Milan, A, Bellsham-Revell, H, Bell, AJ, Miller, OI, Simpson, JM, Hwang, YM, Kim, GH, Jung, MH, Woo, GH, Medicine, Department of Internal, Hospital, St.Vincents, Korea, The Catholic University of, Suwon, Division of Cardiology, Repu, Driessen, MMP, Leiner, T, Schoof, PH, Breur, JMPJ, Sieswerda, GT, Meijboom, FJ, Bellsham-Revell, H, Hayes, N, Anderson, D, Austin, BC, Razavi, R, Greil, GF, Simpson, JM, Bell, AJ, Zhao, XX, Xu, XD, Qin, YW, Szmigielski, C A, Styczynski, G, Sobczynska, M, Placha, G, Kuch-Wocial, A, Ikonomidis, I, Voumbourakis, A, Triantafyllidi, H, Pavlidis, G, Varoudi, M, Papadakis, I, Trivilou, P, Paraskevaidis, I, Anastasiou-Nana, M, Lekakis, I, Kong, WILL, Yip, JAMES, Ling, LH, Milan, A, Tosello, F, Leone, D, Bruno, G, Losano, I, Avenatti, E, Sabia, L, Veglio, F, Zaborska, B, Baran, J, Pilichowska-Paszkiet, E, Sikora-Frac, M, Michalowska, I, Kulakowski, P, Budaj, A, Mega, S, Bono, MC, De Francesco, V, Castiglione, I, Ranocchi, F, Casacalenda, A, Goffredo, C, Patti, G, Di Sciascio, G, Musumeci, F, Kennedy, M, Waterhouse, DF, Sheahan, R, Foley, DF, Mcadam, BF, Ancona, R, Comenale Pinto, S, Caso, P, Arenga, F, Coppola, MG, Calabro, R, Remme, E W, Smedsrud, M K, Hasselberg, N E, Smiseth, O A, Edvardsen, T, Halmai, L, Nemes, A, Kardos, A, Neubauer, S, Degiovanni, A, Baduena, L, Dellera, G, Occhetta, E, Marino, P, Hotchi, J, Yamada, H, Nishio, S, Bando, M, Hayashi, S, Hirata, Y, Amano, R, Soeki, T, Wakatsuki, T, Sata, M, Lamia, B, Molano, LC, Viacroze, C, Cuvelier, A, Muir, JF, Lipczynska, M, Piotr Szymanski, PS, Anna Klisiewicz, AK, Lukasz Mazurkiewicz, LM, Piotr Hoffman, PH, Van T Sant, J, Wijers, SC, Ter Horst, IAH, Leenders, GE, Cramer, MJ, Doevendans, PA, Meine, M, Hatam, N, Goetzenich, A, Aljalloud, A, Mischke, K, Hoffmann, R, Autschbach, R, Sikora-Frac, M, Zaborska, B, Maciejewski, P, Bednarz, B, Budaj, A, Evangelista, A, Torromeo, C, Pandian, NG, Nardinocchi, P, Varano, V, Schiariti, M, Teresi, L, Puddu, PE, Storve, S, Dalen, H, Snare, SR, Haugen, BO, Torp, H, Fehri, W, Mahfoudhi, H, Mezni, F, Annabi, MS, Taamallah, K, Dahmani, R, Haggui, A, Hajlaoui, N, Lahidheb, D, Haouala, H, Colombo, A, Carminati, MC, Maffessanti, F, Gripari, P, Pepi, M, Lang, RM, Caiani, EG, Walker, JR, Abadi, S, Agmon, Y, Carasso, S, Aronson, D, Mutlak, D, Lessick, J, Saxena, A, Ramakrishnan, S, Juneja, R, Ljubas, J, Reskovic Luksic, V, Matasic, R, Pezo Nikolic, B, Lovric, D, Separovic Hanzevacki, J, Quattrone, A, Zito, C, Alongi, G, Vizzari, G, Bitto, A, De Caridi, G, Greco, M, Tripodi, R, Pizzino, G, Carerj, S, Ibrahimi, P, Jashari, F, Johansson, E, Gronlund, C, Bajraktari, G, Wester, P, Henein, MY, Kosmala, W, Marwick, TH, Souza, J R M, Zacharias, L G T, Geloneze, B, Pareja, J C, Chaim, A, Nadruz, W JR, Coelho, O R, Apostolovic, S, Stanojevic, D, Jankovic-Tomasevic, R, Salinger-Martinovic, S, Djordjevic-Radojkovic, D, Pavlovic, M, Tahirovic, E, Musial-Bright, L, Lainscak, M, Duengen, HD, group, CIBIS ELD study, Filipiak, D, Kasprzak, JD, and Lipiec, P

Abstract

Purpose: With the advent of percutaneous transcatheter device closures in congenital heart defects and the emergence of percutaneous left atrial appendage closure, there is an increasingly important role for echocardiographic guidance and control of device position and function. Disc occluder devices frequently present as an unexplained ‘figure-of-8’ on echocardiography. The aim of this study was to clarify this ‘figure-of-8’ display and to relate its morphology to transducer position and device type. Methods: A mathematical model was developed to resemble disc occluder geometry and to allow a numerical simulation of the echocardiographic appearance. In addition, we developed an in vitro set-up for echocardiographic analysis of various disc occluders and various transducer positions. Results: In the mathematical model of an epitrochoid curve (closely resembling disc occluder geometry) a ‘figure-of-8’ display is obtained when emphasizing points with tangent vector perpendicular to the direction of ultrasound waves. Decreasing imaging depth results in a more asymmetric ‘figure-of-8’, with small upper part and wide lower part. Clinical and in vitro data are in close agreement with these results (Figure 1). Furthermore a ‘figure-of-8’ display is only obtained in a coronal imaging position, and is similar for different commercially available disc occluder types. Conclusions: The ‘figure-of-8’ display in the ultrasound image of a disc occluder is an imaging artifact due to the specific ‘epitrochoidal’ geometry of a deployed device and its interaction with ultrasound waves. The morphology of the ‘figure-of-8’ depends on transducer position, i.e. imaging depth, and is similar for different device types. Figure 1 Impact of imaging depth

Published
2013
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26. Abstracts

Author

Treibel, Thomas A., Fridman, Yaron, Hackman, Brianne, Kadakkal, Ajay, Sayeed, Aatif, Maanja, Maren, Daya, Hussein Abu, Moon, James C., Wong, Timothy C., Schelbert, Erik B., Duca, Franz, Kammerlander, Andreas A., Zotter-Tufaro, Caroline, Aschauer, Stefan, Bonderman, Diana, Mascherbauer, Julia, Schwitter, Juerg, Beigelman-Aubry, Catherine, Peguret, Nicolas, Stuber, Matthias, Delacoste, Jean, Belmondo, Bastien, Lovis, Alban, Simons, Julien, Long, Olivier, Grant, Kathleen, Berchier, Gregoire, Rohner, Chantal, Bonanno, Gabriele, Coppo, Simone, Ozsahin, Esat-Mahmut, Qanadli, Salah, Meuli, Reto, Bourhis, Jean, Ide, Seiko, Riesenkampff, Eugenie, Chiasson, David, Dipchand, Anne I., Kantor, Paul F., Chaturvedi, Rajiv R., Yoo, Shi-Joon, Grosse-Wortmann, Lars, Sandrini, C., Aquaro, GD, De Marchi, D, Ait Ali, L, Khraiche, D, Boddaert, N, Bonnet, D, Raimondi, F, Fridman, Yaron, Hackman, Brianne E., Kadakkal, Ajay, Daya, Hussein Abu, Wong, Timothy C., Schelbert, Erik B., Angela, Susana, Alberto, Cipriani, Manuel, De Lazzari, Federico, Marin, Francesca, Prevedello, Bendetta, Giorgi, Giorgio, De Conti, Giuseppe, Tarantini, Luisa, Cacciavillani, Emanuele, Bertaglia, Domenico, Corrado, Sabino, Iliceto, Martina, Perazzolo Marra, Camaioni, Claudia, Morlon, Lucas, Vergé, Marie-Philippe, Jais, Pierre, Roudaut, Raymond, Laurent, Francois, Lafitte, Stéphane, Cochet, Hubert, Réant, Patricia, Bohnen, S., Radunski, U. K., Lund, G. K., Senel, M., Avanesov, M., Tahir, E., Stehning, C., Adam, G., Blankenberg, S., Muellerleile, K., Khanji, Mohammed Y., Balawon, Armida, Boubertakh, Redha, Petersen, Steffen E, Hilbert, Sebastian, Spampinato, Ricardo, Oebel, Sabrina, Hindricks, Gerhard, Bollmann, Andreas, Jahnke, Cosima, Paetsch, Ingo, Goetschalckx, K., Bogaert, J., Desmet, W., Toth, A., Merkely, B., Janssens, S., Claus, P., Calvieri, C., Preda, M. B., Perfetti, A., Valaperta, R., Secchi, F., Fedele, F., Martelli, F., Lombardi, M., Reinstadler, Sebastian J., Eitel, Charlotte, Fuernau, Georg, de Waha, Suzanne, Desch, Steffen, Mende, Meinhard, Metzler, Bernhard, Schuler, Gerhard, Thiele, Holger, Eitel, Ingo, Maestrini, Viviana, Mun, Hong Cheang, Kotwinski, Paul, Rosmini, Stefania, Sanders, Julie, Lloyd, Guy, Dudley, J. Pennell, Kellman, Peter, Hugh, E. Montgomery, Manisty, Charlotte, James, C. Moon, James, S., Waterhouse, D.F., Murphy, T.M., Kenny, C., O'Hanlon, R., Bastiaenen, Rachel, Cox, Andrew T., Wijeyeratne, Yanushi, Colbeck, Nicholas, Pakroo, Nadia, Ahmed, Hammad, Bunce, Nick, Anderson, Lisa, Prasad, Sanjay, Sharma, Sanjay, Behr, Elijah R., Reid, A. B., Miller, C., Jovanovic, A., Woolfson, P., Abidin, N., Schmitt, M., Amadu, A.M., Rodrigues, J.C.L., Dastidar, A. Ghosh, Baritussio, A., Lawton, C., Venuti, G., Meloni, G.B., Conti, M., Bucciarelli-Ducci, C., Pontone, Gianluca, Andreini, Daniele, SoLbiati, Anna, Guglielmo, Marco, Mushtaq, Saima, Baggiano, Andrea, Beltrama, Virginia, Rota, Cristina, Guaricci, Andrea I., Pepi, Mauro, Wang, Yufei, Joannic, David, Juillion, Patrick, Delassus, P., Monnet, Aurélien, Lalande, Alain, Fontaine, Jean-Francois, Zweerink, A, Allaart, CP, Wu, L, Kuijer, JPA, Beek, AM, Croisille, P, Clarysse, P, van Rossum, AC, Nijveldt, R, Bulluck, Heerajnarain, Rosmini, Stefania, Abdel-Gadir, Amna, Bhuva, Anish, Treibel, Thomas A, White, Steven K, Hammond-Haley, Matthew, Sirker, Alex, Herrey, Anna, Manisty, Charlotte, Yellon, Derek M, Kellman, Peter, Moon, James C, Hausenloy, Derek J, Garg, P., Hassell, M, Foley, J., Ripley, D.P., Dobson, L., Swoboda, P.P., Fent, G., Musa, T.A., Erhayiem, B., Haaf, P., Greenwood, J.P., Nijveldt, R., Westenberg, J.J.M., Geest, R.J.V.D., Plein, S., Rodrigues, Jonathan C L, Amadu, Antonio Matteo, Dastidar, Amardeep Ghosh, Szantho, Gergley, Lyen, Stephen, Godsave, Cattleya, Ratcliffe, Laura E K, Burchell, Amy E, Hart, Emma C, Hamilton, Mark C K, Nightingale, Angus K, Paton, Julian F R, Manghat, Nathan E, Bucciarelli-Ducci, Chiara, Hafyane, Tarik, Teixeira, Tiago, Greiser, Andreas, Mongeon, Francois Pierre, Haifa, Almutairi, Mohammed, Khanji, Redha, Boubertakh, Marc, Miquel, Steffen, Petersen, Greulich, S., Kitterer, D., Latus, J., Henes, J., Kurmann, R., Gloekler, S., Wahl, A., Buss, S., Katus, H., Bobbo, M., Lombardi, M., Braun, N., Alscher, M.D., Sechtem, U., Mahrholdt, H., Meloni, A., Neri, M.G., Preziosi, P., Grassedonio, E., Schicchi, N., Keilberg, P., Pulini, S., Facchini, E., Positano, V., Pepe, A., Nazir, Sheraz A., Shetye, Abhishek, Khan, Jamal N., Singh, Anvesha, Kanagala, Prathap, Swarbrick, Daniel, Gulsin, Gaurav, Graham-Brown, Matthew, Squire, Iain, Gershlick, Anthony, McCann, Gerry P., Stefan Biesbroek, P., Amier, Raquel P., Teunissen, Paul F.A., Robbers, Lourens F.H.J., Beek, Aernout M., van Rossum, Albert C., Hofman, Mark B.M., van Royen, Niels, Nijveldt, Robin, Arenja, Nisha, Riffel, Johannes H, Djiokou, Charly Noel, Andre, Florian, Fritz, Thomas, Halder, Manuel, Thomas, Zelniker, Korosoglou, Grigorios, Katus, Hugo A, Buss, Sebastian J, Kammerlander, Andreas A., Schwaiger, Marianne L., Duca, Franz, Aschauer, Stefan, Marzluf, Beatrice A., Zotter-Tufaro, Caroline, Dalos, Daniel, Pfaffenberger, Stefan, Bonderman, Diana, Mascherbauer, Julia, Sayeed, Aatif, Fridman, Yaron, Hackman, Brianne, Kadakkal, Ajay, Maanja, Maren, Daya, Hussein Abu, Wong, Timothy C., Schelbert, Erik B., Ricci, F., Barison, A., Todiere, G., Gaeta, R., Galllina, S., Emdin, M., De Caterina, R., Aquaro, G.D., Bernhardt, Peter, Buckert, Dominik, Dyckmanns, Nils, Rottbauer, Wolfgang, Meierhofer, Christian, Kühn, Andreas, Shehu, Nerejda, Müller, Jan, Stern, Heiko, Ewert, Peter, Fratz, Sohrab, Vogt, Manfred, Devos, Daniel G.H., De Groote, Katya, Babin, Danilo, Demulier, Laurent, Taeymans, Yves, Westenberg, Jos J., Van Bortel, Luc, Segers, Patrick, Achten, Eric, De Schepper, Jean, Rietzschel, Ernst, Ruecker, Beate, Geiger, Julia, Makki, Malek, Burkhardt, Barbara, Kellenberger, Christian J., Buechel, Emanuela R. Valsangiacomo, Burkhardt, B.E.U., Kellenberger, C.J., Geiger, J., Ruecker, B., Buechel, E.R. Valsangiacomo, Kamphuis, Vivian P., Elbaz, Mohammed S.M., Kroft, Lucia J.M., van der Geest, Rob J., de Roos, Albert, Blom, Nico A., Westenberg, Jos J.M., Roest, Arno A.W., De Lazzari, Manuel, Cipriani, Alberto, Susana, Angela, Rizzo, Stefania, Giorgi, Benedetta, Carmelo, Lacognata, Bertaglia, Emanuele, Bauce, Barbara, Corrado, Domenico, Thiene, Gaetano, Marra, Martina Perazzolo, Basso, Cristina, Iliceto, Sabino, Nederend, I., Roest, A.A.W., van den Boogaard, P.J., ten Harkel, A.D.J., de Geus, J.C.N., Kroft, L.J.M., de Roos, A., Westenberg, J.J.M., Dux-Santoy, Lydia, Kale, Raquel, Teixido-Tura, Gisela, Maldonado, Giuliana, Huguet, Marina, Garcia-Dorado, David, Evangelista, Artur, Rodriguez-Palomares, Jose, Cavalcante, João L., Rijal, Shasank, Schindler, John T., Gleason, Thomas G., Lee, Joon S., Schelbert, Erik B., Rosmini, Stefania, Bulluck, Heerajnarain, Treibel, Thomas A, Bhuva, Anish, Abdel-Gadir, Amna, Culotta, Veronica, Merghani, Ahmed, Maestrini, Viviana, Herrey, Anna S, Kellman, Peter, Manisty, Charlotte, Moon, James C, Liu, B., Hayer, M.K., Baig, S., Shah, T., Rooney, S.J., Edwards, N.C., Steeds, R.P., Fent, G.J., Garg, P., Swoboda, P., Dobson, L.E., Musa, T.A., Foley, J.F., Haaf, P., Greenwood, J.P., Plein, S., Claessen, G., Schnell, F., Bogaert, J., Dymarkowski, S., Pattyn, N., Claus, P., Van Cleemput, J., Gerche, A. La, Heidbuchel, H., Behar, Jonathan, Toth, Daniel, Reiml, Sabrina, Panayiotou, Maria, Claridge, Simon, Jackson, Tom, Sohal, Manav, Webb, Jessica, O'Neill, Mark, Brost, Alexander, Mountney, Peter, Razavi, Reza, Rhode, Kawal, Rinaldi, Christopher Aldo, Oebel, S., Arya, A., Hilbert, S., Bollmann, A., Hindricks, G., Jahnke, C., Paetsch, I., Dinov, B., Baritussio, A., Perazzolo Marra, M., Ghosh Dastidar, A., Rodrigues, J., Zorzi, A., Susana, A., Scatteia, A., De Garate, E., Mattesi, G., Strange, J., Corrado, D., Bucciarelli-Ducci, C., Ranjit Arnold, J., Jerosch-Herold, Michael, Karamitsos, Theodoros D., Francis, Jane M., Bhamra-Ariza, Paul, Sarwar, Rizwan, Choudhury, Robin, Selvanayagam, Joseph B., Neubauer, Stefan, Tayal, Upasana, Scott, Andrew D, Wage, Rick, Ferreira, Pedro, Pennell, Dudley, Zhong, Xiaodong, Epstein, Fred, Firmin, David, Prasad, Sanjay, Kallifatidis, Alexandros, Prousalis, Anastasios, Mouratoglou, Sophia-Anastasia, Giannakoulas, George, Deligianni, Xenia, Bakaloudis, Michail, Magganaris, Nikolaos, Sianos, George, Karvounis, Haralampos, Santini, Francesco, Garg, P., Aziz, R., Foley, J.R.J., Fent, G., Musa, T.A., Haaf, P., Dobson, L., Swoboda, P.P., Greenwood, J.P., Plein, S., Geest, R.J.V.D., Westenberg, J.J.M., Beitzke, D., Rasul, S., Wadsak, W., Mitterhauser, M., Nolz, R., Stelzmueller, M., Loewe, C., Hacker, M., Funk, Stephanie, Kermer, Josephine, Dogangüzel, Serkan, von Knobelsdorff-Brenkenhoff, Florian, Schulz-Menger, Jeanette, Kolker, Shimon, Weisz, Giora, Bogot, Naama, Halpern, Irit Hadas, Wolak, Arik, Rutz, Tobias, Ginami, Giulia, Piccini, Davide, Coppo, Simone, Vincenti, Gabriella, Stuber, Matthias, Schwitter, Jürg, Safdar, Komal S, Gao, Xuexin, Ambach, Stephanie, Taylor, Michal D, Moore, Ryan, Taylor, Robin J, Toro-Salazar, Olga, Jeffries, John L, Bartone, Cheryl, Raman, Subha V, Mazur, Wojciech, Valente, F., Rodriguez-Palomares, J.F., Gutierrez, L., Pineda, V., Agliano, B., Galian, L., Teixido, G., Gonzalez-Alujas, M.T., Evangelista, A., Garcia-Dorado, D., Murdoch, R., Gandy, S., Nicholas, R., Houston, G., Martin, P., Muir, J., Matthew, S., Ramkumar, P. Guntur-, Cavin, I., Macaione, F., Barison, A., Pescetelli, I., Pali, F., Pizzino, F., Terrizzi, A., Di Lisi, D., Novo, G., Todiere, G., Assennato, P., Novo, S., Aquaro, G.D., Dastidar, Amardeep Ghosh, McAlindon, Elisa, Rodrigues, Jonathan, Baritussio, Anna, Scatteia, Alessandra, De Garate, Estefania, Benny Lawton, Chris, Erdei, Tamas, Szantho, Gergely, Hamilton, Mark, Bucciarelli-Ducci, Chiara, Pontone, Gianluca, Andreini, Daniele, Rota, Cristina, Guglielmo, Marco, Mushtaq, Saima, Baggiano, Andrea, Beltrama, Virginia, Solbiati, Anna, Guaricci, Andrea I., Pepi, Mauro, Grigoratos, Chrysanthos, Bratis, Konstantinos, Henningson, Markus, Dell'Omodarme, Matteo, Puntmann, Valentina O., Nagel, Eike, Meloni, Antonella, Giunta, Nicola, Giuliano, Pietro, Neri, Maria Giovanna, Restaino, Gennaro, Renne, Stefania, Quota, Alessandra, Positano, Vincenzo, De Marchi, Daniele, Pepe, Alessia, Pedrotti, Patrizia, Campadello, Paola, Masciocco, Gabriella, Facchetti, Rita, Milazzo, Angela, Quattrocchi, Giuseppina, Giannattasio, Cristina, Frigerio, Maria, Roghi, Alberto, Rimoldi, Ornella, De Garate, Estefania, Ghosh Dastidar, Amardeep, Baritussio, Anna, Scatteia, Alessandra, Amadu, Antonio, Venuti, Giuseppe, Rodrigues, Jonathan C., Bucciarelli-Ducci, Chiara, Careri, Giulia, Castelvecchio, Serenella, Camporeale, Antonia, Secchi, Francesco, Menicanti, Lorenzo, Lombardi, Massimo, Kockova, R., Sedlacek, K., Wichterle, D., Sikula, V., Tintera, J., Sukupova, L., Kautznerova, D., Segetova, M., Praveckova, A., Langova, R., Kryze, L., El-Husseini, W., Kautzner, J., Oebel, S., Dinov, B., Arya, A., Hilbert, S., Sommer, P., Bollmann, A., Hindricks, G., Paetsch, I., Jahnke, C., Nazir, Sheraz A., Greenwood, John P., Shetye, Abhishek, Khan, Jamal N., Singh, Anvesha, Kanagala, Prathap, Swarbrick, Daniel, Gulsin, Gaurav, Graham-Brown, Matthew, Gershlick, Anthony, McCann, Gerry P., Grigoratos, Chrysanthos, Liga, Riccardo, Bennatti, Elena, Barison, Andrea, Todiere, Giancarlo, Aquaro, Giovanni Donato, Dell'Omodarme, Matteo, Lombardi, Massimo, Emdin, Michele, Masci, Pier Giorgio, Barison, A, Ortalda, A, Todiere, G, Grigoratos, C, Vergaro, G, Mirizzi, G, Martini, N, De Marchi, D, Keilberg, P, Passino, C, Aquaro, GD, Emdin, M, Swoboda, Peter P, McDiarmid, Adam K, Erhayiem, Bara, Fent, Graham J, Dobson, Laura E, Garg, Pankaj, Musa, Tarique A, Foley, James R, Page, Stephen P, Greenwood, John P, Plein, Sven, Bulluck, Heerajnarain, Rosmini, Stefania, Abdel-Gadir, Amna, Bhuva, Anish, Treibel, Thomas A, White, Steven K, Fontana, Marianna, Ramlall, Manish, Hamarneh, Ashraf, Sirker, Alex, Herrey, Anna, Manisty, Charlotte, Yellon, Derek M, Kellman, Peter, Moon, James C, Hausenloy, Derek J, Broncano, J., Luna, A., Noguerol, T. Martin –, Caro, P., Toro-Cebada, R., Gonzalez, J. Sanchez –, Desroche, L.M., Milleron, O., Safar, B., Lavie-Badie, Y., Millischer, D., Abtan, J., Jondeau, G., Bermejo, Zorba Blázquez, Cuesta, Emilio, Rosillo, Sandra O., Guzmán, Gabriela, Pinilla, Inmaculada, González, Óscar, Caro, Juan, Ponz, Inés, López, Teresa, Refoyo, Elena, Kozor, Rebecca, Nordin, Sabrina, Treibel, Thomas A, Rosmini, Stefania, Castelleti, Silvia, Fontana, Marianna, Captur, Gabriella, Steeds, Rick, Baig, Shanat, Manisty, Charlotte, Grieve, Stuart M, Figtree, Gemma A, Moon, James C, Dastidar, Amardeep Ghosh, Rodrigues, Jonathan, De Garate, Estefania, Singhal, Priyanka, McAlindon, Elisa, Baritussio, Anna, Scatteia, Alessandra, Erdei, Tamas, Strange, Julian, Nightingale, Angus, Baumbach, Andreas, Johnson, Tom, Delgado, Victoria, Bucciarelli-Ducci, Chiara, Lapinskas, Tomas, Bucius, Paulius, Fedaravicius, Augustinas P., Urbonaite, Laura, Stabinskaite, Agnieta, Zaliunas, Remigijus, Elisabetta, Chiodi, Teresa, Cannizzaro Maria, Daniele, De Falco Alfano, Righi, Riccardo, Zerbini, Michela, Vincenzo, Positano, Cittanti, Corrado, Giganti, Melchiore, Giorgio, Benea, Grigoratos, Chrysanthos, Genovesi, Dario, Giorgetti, Assuero, Chiappino, Sara, Barison, Andrea, Vergaro, Giuseppe, Todiere, Giancarlo, Emdin, Michele, Marzullo, Paolo, Aquaro, Giovanni Donato, Ladeiras-Lopes, Ricardo, Turin-Moreira, Henrique, Bettencourt, Nuno, Fontes-Carvalho, Ricardo, Sampaio, Francisco, Ambale-Venkatesh, Bharath, Wu, Colin, Liu, Kiang, Bertoni, Alain, Ouyang, Pamela, Bluemke, David, Lima, João, Fent, GJ., Garg, P., Dobson, LE., Musa, TA., Foley, JF., Haaf, P., Greenwood, JP., Plein, S., Swoboda, PP., Abdul Rahman, E., Ismail, JR., Najme Khir, R., Lim, CW., Chua, N., Ibrahim, ZO., Zainal Abidin, HA., Mohd Arshad, MK., Kasim, SS., Rodrigues, Jonathan, Rooms, Ben, Hyde, Katie, Rohan, Stephen, Dastidar, Amardeep Ghosh, Hamilton, Mark, Bucciarelli-Ducci, Chiara, Nightingale, Angus, Paton, Julian, Manghat, Nathan, MacIver, David, Gibelli, Giuseppe, Demolli, Walter, Russo, Alessandra, Minoia, Chiara, Biasi, Salvatore, Mkrtchyan, Naira, Eltschkner, Christin, Christian, Meierhofer, Ewert, Peter, Martinoff, Stefan, Stern, Heiko, Fratz, Sohrab, Valinoti, Maddalena, Fabbri, Claudio, Mantovan, Roberto, Severi, Stefano, Corsi, Cristiana, Nyktari, E., Vassiliou, V., Arzanauskaite, M., Izgi, C., Lam, W., Prasad, S., Reindl, Martin, Reinstadler, Sebastian Johannes, Feistritzer, Hans-Josef, Klug, Gert, Mair, Johannes, Mayr, Agnes, Jaschke, Werner, Franz, Wolfgang-Michael, Metzler, Bernhard, Arnhold, K., Muehlberg, F., Fritschi, S., Funk, S., Prothmann, M., von Knobelsdorff-Brenkenhoff, F., Schulz-Menger, J., Lakhani, Zeeshan S. A., Mohan, B., karthik, G A., Raj, Vimal, Weir-McCall, Jonathan, Cassidy, Deirdre B, Belch, Jill JF, Gandy, Stephen J, Houston, Graeme, Lambert, Matthew A, Littleford, Roberta, Rowland, Janice, Struthers, Allan D, Khan, Faisel, Camaioni, Claudia, Salel, Marjorie, Hennig, Alexia, Corneloup, Olivier, Montaudon, Michel, Laurent, Francois, Cochet, Hubert, Kan, Rachel, Erhayiem, Bara, McDiarmid, Adam K., Garg, Pankaj, Dobson, Laura E., Musa, Tarique A., Ripley, David, Ajjan, Ramzi, Greenwood, John P., Plein, Sven, Swoboda, Peter P., Reinstadler, Sebastian J., Fuernau, Georg, Eitel, Charlotte, de Waha, Suzanne, Desch, Steffen, Metzler, Bernhard, Schuler, Gerhard, Thiele, Holger, Eitel, Ingo, Feistritzer, Hans-Josef, Reinstadler, Sebastian Johannes, Klug, Gert, Reindl, Martin, Mair, Johannes, Mayr, Agnes, Franz, Wolfgang-Michael, Metzler, Bernhard, Feistritzer, Hans-Josef, Klug, Gert, Reinstadler, Sebastian Johannes, Reindl, Martin, Mayr, Agnes, Franz, Wolfgang-Michael, Metzler, Bernhard, Festa, P., Cadoni, A., D'andrea, C., Costa, S., Keilberg, P., Lunardini, A., Ali, L. Ait, Ali, L. Ait, Aquaro, GD., Peritore, G., Ricci, F., De Marchi, D., Passino, C., Festa, P., Martínez, A. Tercero, Cuartero, J. Navarro, Soriano, J.G. Córdoba, Núñez, S. Calero, de Galarreta, T. Cros Ruiz, García, M. Villar, Page, J.C. Gallego, López, J.C. García, Ruiz, M. Barambio, Erdei, Tamas, Rodrigues, Jonathan C., McIntyre, Bethannie, Dastidar, Amardeep Ghosh, Burchell, Amy E., Ratcliffe, Laura, Hart, Emma C., Paton, Julian F., Hamilton, Mark, Nightingale, Angus K., Manghat, Nathan E., Orii, Makoto, Tanimoto, Takashi, Ota, Shingo, Nishiguchi, Tsuyoshi, Tsujioka, Hiroto, Kuroi, Akio, Yamano, Takashi, Matsuo, Yoshiki, Ino, Yasushi, Kitabata, Hironori, Kubo, Takashi, Tanaka, Atsushi, Hozumi, Takeshi, Akasaka, Takashi, Sousa, Alexandra, Pinho, Teresa, Canedo, Paulo, Lopes, Luís, Azevedo, Olga, Madureira, António, Belo, Adriana, Cardoso, José Silva, Machado, José Carlos, Martins, Elisabete, Brzozowska-Czarnek, Agata, Urbanik, Andrzej, Brzozowska-Czarnek, Agata, Urbanik, Andrzej, Rakowski, Tomasz, Agudo-Quílez, P., Pozo-Osinalde, E., Viliani, D., Olivera, MJ., Caballero, P., Jiménez-Borreguero, LJ., Alfonso, F., Carrabba, Nazario, Angeloni, Giulia, Migliorini, Angela, Valenti, Renato, Parodi, Guido, Antoniucci, David, Almeida-Morais, Luís, Galrinho, Ana, Moura-Branco, Luísa, Tavares-Jalles, Nuno, António, Marta, Abreu, João, Timóteo, Ana Teresa, Pinto-Teixeira, Pedro, Aguiar-Rosa, Sílvia, Rodrigues, Inês, Modas-Daniel, Pedro, Cruz-Ferreira, Rui, Bica, R., Dobre, D., Stanciu, S., Acatrinei, E., Nour, A., Stefan, L., Calistru, P., Rajewska-Tabor, J., Pyda, M., Janus, M., Siniawski, A., Rajewska-Tabor, J., Pyda, M., Janus, M., Siniawski, A., Shaheen, Sameh Mohamed, Elhammady, Walid Abdel-Azim, Ahmed, Mohamed Ismail, Abdel-Hakim, Ahmed Samir, Allam, Lamyaa Elsayed, Helal, Ayman Mohamed, Inage, Akio, Mizuno, Naokazu, Inage, Akio, Mizuno, Naokazu, TEIS, Albert, JUNCÀ, Gladys, ARCE, Javier, ARMARIO, David, Cescau, Arthur, Logeart, Damien, Gelen, Barnabas, Derumeaux, Genevie`ve, Vicaut, Eric, Mercadier, Jean-Jacques, Sirol, Marc, Cipriani, Alberto, De Lazzari, Manuel, Susana, Angela, Zorzi, Alessandro, Baritussio, Anna, Siciliano, Mariachiara, Marinato, Martina, Prevedello, Francesca, Giorgi, Benedetta, Vezzaro, Roberto, Corrado, Domenico, Marra, Martina Perazzolo, von Roeder, M., Rommel, K.-P., Kowallick, J.T., Blazek, S., Fengler, K., Lotz, J., Hasenfuß, G., Lücke, Ch., Gutberlet, M., Schuler, G., Schuster, A., Lurz, Ph., Mahmoud, Ahmad A., Rifaie, Osama, Samir, Ahmed, Allam, Lamyaa, Duca, Franz, Kammerlander, Andreas A., Zotter-Tufaro, Caroline, Aschauer, Stefan, Bonderman, Diana, Mascherbauer, Julia, She, Hoi Lam, Roest, Arno A.W., van den Boogaard, Pieter J., Calkoen, Emmeline E., van der Geest, Rob J., Hazekamp, Mark G., de Roos, Albert, Westenberg, Jos J.M., Burkhardt, B.E.U., Kellenberger, C.J., Geiger, J., Ruecker, B., Buechel, E.R. Valsangiacomo, Bainbridge, G., Garg, P., Foley, J.R.J., Fent, G., Musa, T.A., Haaf, P., Dobson, L., Swoboda, P.P., Greenwood, J.P., Plein, S., Charalambos, Max, Rodrigues, Jonathan, Burchell, Amy, Dastidar, Amardeep Ghosh, BSc(Hons), Laura Ratcliffe, Hart, Emma, Hamilton, Mark, Paton, Julian, Nightingale, Angus, Manghat, Nathan, Muñoz, Begoña Igual, Monserrat, Adrian, gonzalez, Alicia Maceira, Tuset, Luis, Miro, Vicente, Hernandiz, Amparo, Fernandez, Rubén, Sauri, Asunción, Sepúlveda, Pilar, Diez, Jose Luis, Montero, Anastasio, Contaldi, Carla, Imbriaco, Massimo, Alcidi, Gianmarco, Ponsiglione, Andrea, Santoro, Ciro, Puglia, Marta, Barbuto, Luigi, Cuocolo, Alberto, Trimarco, Bruno, Galderisi, Maurizio, Muñoz, Begoña Igual, Sanchez, Elena, Plaza, Diego, sanchis, Pilar Sepúlveda, Gonzalez, Alicia Maceira, Hernandiz, Amparo, Miro, Vicente, vazquez, Alex, Diez, Jose Luis, Martinez, Luis, Montero, Anastasio, Muñoz, B. Igual, Alfredo, Hernandez Caballero, Diana, Domingo Valero, Alicia, Maceira Gonzalez, Jordi, Estornell Erill, Jose, Valera martinez Francisco, Alejandro, Vazquez Sanchez, Anastasio, Montero Argudo, Mochula, O.V., Shelkovnikova, T.A., Popov, S.V., Lukyanenok, P.I., Shelupanov, A.A., Oferkin, A.I., Bakhmet'eva, T.A., Ussov, W.Yu., van den Bosch, Harrie CM., Westenberg, Jos JM., Setz-Pels, Wikke, Kersten, Erik, Tielbeek, Alexander, Duijm, Lucien EM., Post, Johannes, Teijink, Joep A.W., de Roos, Albert, Frick, M., Kirschfink, A., Mühler, E., Marx, N., Hövels-Gürich, H., Gert, Klug, Hans-Josef, Feistritzer, Sebastian, Reinstadler, Martin, Reindl, Benjamin, Seidner, Agnes, Mayr, Sylvana, Müller, Bernhard, Metzler, Fawal, aSara E., Zidan, aMamdouh, Webb, Jessica, Holub, Ondrej, Clough, Rachel, Carr-White, Gerald, Razavi, Reza, Sinkus, Ralph, Maksimova, A.S., Bobrikova, E.E., Bukhovets, I.L., Plotnikov, M.P., Rogovskaya, Yu.V., Rebenkova, M.S., Usov, W.Yu., Mayr, Agnes, Klug, Gert, Feistritzer, Hans-Josef, Reinstadler, Sebastian Johannes, Reindl, Martin, Metzler, Bernhard, Kremser, Christian, Schocke, Michael, Winter, M.M., Pluchinotta, F.R., Giusti, G., Secchi, F., Piazza, L., Carminati, M., Chessa, M., Bokma, J.P., Bouma, B.J., Mulder, B.J., Lombardi, M., Katia, Menacho, Thomas, Treibel, Rebecca, Kozor, Heeraj, Bulluck, James, Moon, Charlotte, Manisty, Sztajzel, Juan, Bertron, Fabienne, Papavassiliu, Theano, Oezkan, Sueheyla, Lossnitzer, Dirk, Schoenberg, Stefan O., Borggrefe, Martin, Doesch, Christina, Baig, S., Edwards, NC., Liu, B., Hayer, MK., Dawson, CH., Geberhiwot, T., Steeds, RP., Shehu, N., Stern, H., Mkrtchyan, N., Meierhofer, C., Martinoff, S., Ewert, P., Fratz, S., Pais, João, Picarra, Bruno, Santos, Ana Rita, Guerreiro, Rui, Congo, Kisa Hyde, Carvalho, João, Neves, David, Aguiar, José, Vinco, Giulia, Fischer, Kady, Labelle, Chantal, Gelineau, Sylvie, Farkas, Sandra, Lebel, Julie, Friedrich, Matthias G., Webb, Jessica, Villa, Adriana, Bekri, Imane, Shome, Joy, Teall, Tom, Di Giovine, Gabriella, Sammut, Eva, Carr-White, Gerald, Al-Fakih, Khaled, Chiribiri, Amedeo, Kamphuis, Vivian P., Roest, Arno AW., Kroft, Lucia JM., van der Geest, Rob J., de Roos, Albert, Blom, Nico A., Westenberg, Jos JM., Elbaz, Mohammed SM., Bensaoud, M., Soufiani, A., Barahioui, H., Bayi, A., Fellat, N., Benjelloun, H., Tazi, Z., Abawi, Masieh, Elisabetta, Chiodi, Teresa, Cannizzaro Maria, Daniele, De Falco Alfano, Righi, Riccardo, Zerbini, Michela, Vincenzo, Positano, Cittanti, Corrado, Giganti, Melchiore, Giorgio, Benea, Elisabetta, Chiodi, Teresa, Cannizzaro Maria, Daniele, De Falco Alfano, Righi, Riccardo, Zerbini, Michela, Vincenzo, Positano, Cittanti, Corrado, Giganti, Melchiore, Giorgio, Benea, Musa, TA., Uddin, A., Dobson, LE., Swoboa, PP., Garg, P., Fent, GJ., Foley, JRJ., Malkin, CJ., Plein, S., Blackman, DJ., Greenwood, JP., Yun, Chun-Ho, Bezerra, Hiram G., Richmond, C., Dobson, LE., Swoboda, PP., Musa, TA., Foley, JF., Garg, P., Haaf, P., Fent, GJ., Plein, S., Greenwood, JP., Meloni, Antonella, Gamberini, Maria Rita, Neri, Maria Giovanna, Cuccia, Liana, D'Ascola, Domenico Giuseppe, Tudisca, Chiara, Vinci, Valentina, Positano, Vincenzo, Pepe, Alessia, Meloni, Antonella, Borgna-Pignatti, Caterina, Del Vecchio, Giovanni Carlo, Romeo, Maria Antonietta, Gamberini, Maria Rita, Bonetti, Federico, Neri, Maria Giovanna, Missere, Massimiliano, Salvatori, Cristina, Pepe, Alessia, Dobson, LE., Musa, TA., Uddin, A., Fairbairn, TA., Bebb, OJ., Swoboda, PP., Haaf, P., Foley, J., Garg, P., Fent, GJ., Malkin, CJ., Blackman, DJ., Plein, S., Greenwood, JP., Schneeweis, C., Eckert, J., Tröbs, M., Magedanz, A., Schmidt, M., Voigtländer, T., Schmermund, A., Achenbach, S., Foley, JRJ., Dobson, LE., Musa, TA., Swoboda, PP., Garg, P., Fent, GF., Haaf, P., Malkin, CJ., Blackman, DJ., Plein, S., Greenwood, JP., Matthew, S., McCall, J. Weir, Gandy, S.J., Milne, W.G., Houston, J.G, Meloni, A., Ricchi, P., Spasiano, A., Neri, MG., Vallone, A., Resta, MC., Righi, R., Keilberg, P., Santamaria, V., Positano, V., Pepe, A., Henein, Michael Y., Bengrid, Tarek, Nicoll, Rachel, Zhao, Ying, Johansson, Bengt, Schmermund, Axel, Barbanti, Marco, Cascone, Irene, Miccichè, Eligio, Buccheri, Sergio, Immè, Sebastiano, Pilato, Gerlando, Tamburino, Claudia, Patanè, Martina, Gulino, Simona, Todaro, Denise, Salerno, Tatiana, Garretto, Valeria, Privitera, Gianbattista, Capodanno, Davide, Tamburino, Corrado, Manna, Alessio La, Vincenti, Gabriella, Masci, Pier-Giorgio, Rutz, Tobias, De Blois, Jonathan, Schwitter, Juerg, Monney, Pierre, Paelinck, Bernard P., Vandendriessche, Tom, De Bock, Dina, Parizel, Paul M., Rodrigus, Inez E., Claeys, Marc J., Leone, D., Tosello, F., Bruno, G., Avenatti, E., Faletti, R., Ravera, A, Veglio, F., Milan, A., Meloni, A., Maggio, A., Leto, F., Pitrolo, L., De Marchi, D., Positano, V., Neri, MG., Pepe, A., Pizzino, F., Meloni, A., Terrizzi, A., Aquaro, GD., Neri, MG., Spasiano, A., Serra, M., Allò, M., Keilberg, P., Positano, V., Di Bella, G., Zito, C., Pepe, A., Saunders, Laura, Stewart, Neil J., Hammerton, Charlotte, Capener, David, Puntmann, Valentina O, Graves, Martin J., Kiely, David G., Wild, Jim M., Swift, Andrew J., Macaione, F., Meloni, A., Barison, A., Neri, MG., Positano, V., Salvatore, N., Assennato, P., Pepe, A., Kammerlander, Andreas A., Aschauer, Stefan, Marzluf, Beatrice A., Zotter-Tufaro, Caroline, Duca, Franz, Knechtelsdorfer, Klaus, Wiesinger, Matthias, Dalos, Daniel, Pfaffenberger, Stefan, Bonderman, Diana, Mascherbauer, Julia, Haberka, Maciej, Sosnowski, Maciej, Gasior, Zbigniew, Aslam, Sajid, El-Hamamsy, Ismail, SM, Francois-Pierre Mongeon, Bethke, Anne, Eritsland, Jan, Shanmuganathan, Limalanathan, Abdelnoor, Mikael, Andersen, Geir Øystein, Kløw, Nils Einar, Hoffmann, Pavel, Bouhzam, Najime, Caudron, Jérôme, Tron, Christophe, Camacho, Carlos Rodriguez, Cribier, Alain, Dacher, Jean Nicolas, Eltchaninoff, Hélène, Foley, JRJ., Garg, P., Musa, TA., Dobson, LE., Swoboda, PP., Fent, GJ., Haaf, P., Plein, S., Greenwood, JP., Heck, Siri Lagethon, Gulati, Geeta, Von Knobelsdorff-Brenkenhoff, Florian, Storas, Tryggve Holck, Schulz-Menger, Jeanette, Hoffmann, Pavel, Omland, Torbjørn, Kermer, J., Traber, J., Utz, W., Hennig, P., Menza, M., Jung, B., Greiser, A., Kuijer, J., Barckow, P., von Knobelsdorff-Brenkenhoff, F., Töpper, A., Schulz-Menger, J, Malanchini, Giovanni, Moscatelli, Sara, Di Giovine, Gabriella, Balzarini, Luca, Del Corral, Maria Pia, Gasparini, Gabriele, Montini, Orsola, Monti, Lorenzo, Aquaro, Giovanni Donato, Briatico, Alessandra, Toia, Patrizia, Barison, Andrea, Ait-Ali, Lamia, Midiri, Massimo, Cotroneo, Antonio Raffaele, Festa, Pierluigi, Aquaro, G.D., Pizzino, F., Terrizzi, A., Todiere, G., Grigoratos, C., Barison, A., Di Bella, G., Igual-Muñoz, Begoña, de Carranza, María Jose Sancho-Tello, Maceira-Gonzalez, Alicia, Buendía-Fuentes, Francisco, Estornell-Erill, Jordi, Cano-Perez, Oscar, Montero, Anastasio, Igual, Begoña, Sanz, Jorge, Maceira, Alicia, Miro, Vicente, Minguez, Ana Bel, Guillen, Manuel Perez, Lopez, Raquel, Vazquez, Alex, Diez, Jose Luis, rené, Oscar, sepúlveda, Pilar, argudo, Anastasio Montero, Roy, Clotilde, Slimani, Alisson, Amzulescu, Mihaela, de Ravenstein, Christophe de Meester, Pasquet, Agnès, Vancraeyenest, David, Vanoverschelde, Jean-Louis, Gerber, Bernhard, Pouleur, Anne-Catherine, Scatteia, Alessandra, Rodrigues, Jonathan, Lyen, Stephen, De Gerate, Estefania, Baritussio, Anna, Dastidar, Amardeep Ghosh, Maceira, Alicia, Pennell, Dudley, Bucciarelli-Ducci, Chiara, Katulska, Katarzyna, Kociemba, Anna, Rajewska-Tabor, Justyna, Janus, Magdalena, Siniawski, Andrzej, Stajgis, Marek, Pyda, Małgorzata, Brzostowicz, Tomasz, Brzostowicz, Marta, Gibbs, TGJ, Villa, AD, Sammut, E, Mullen, G, Ganeshan, B, Chiribir, A, Singh, Anvesha, McCann, Gerry P, Investigators, the PRIMID-AS, Le, Thu-Thao, Su, Boyang, Cai, Jiasheng, Han, Yiying, Tan, Ru San, Cook, Stuart A, Chin, Calvin WL, Scatteia, Alessandra, Vollema, E. Mara, Leung, Melissa, Marsan, Nina Ajmone, Baritussio, Anna, De Garate, Estefania, Dastidar, Amardeep Ghosh, Rodrigues, Jonathan, Bax, Jeroen J, Delgado, Victoria, Bucciarelli-Ducci, Chiara, Baritussio, A., De Garate, E., Dastidar, A. Ghosh, Ahmed, N., Scatteia, A., Rodrigues, J., Lawton, C., Thomas, Glyn, Duncan, Edward, Cripps, Tim, Diab, Ihab, Bucciarelli-Ducci, C., Treibel, TA., Fontana, M., Kozor, R., Macrae, R., Malcolmson, JW., Menacho, KD., Scully, PR., Lawrence, DR., Sheikh, AM., Herrey, AS., Manisty, C., Moon, JC., Hinojar, R., Golfin, C. Fernandez, Portugal, JC., Esteban, A., Megias, A., Gomez, A. Gonzalez, Rincon, LM., Nacher, JJ. Jimenez, Zamorano, JL., Valente, F., Gutierrez, L., Maldonado, G., Pineda, V., Agliano, B., Galian, L., Teixido, G., Gonzalez-Allujas, MT., Evangelista, A., Garcia-Dorado, D., Rodriguez-Palomares, JF., Fratz, Sohrab, Belker, Kristina, Naumann, Susanne, Martinoff, Stefan, Stern, Heiko, Shehu, Nerejda, Mkrtchyan, Naira, Meierhofer, Christian, Eicken, Andreas, Ewert, Peter, Hilbert, Sebastian, Weber, Alexander, Oebel, Sabrina, Hindricks, Gerhard, Jahnke, Cosima, Paetsch, Ingo, van der Palen, RLF., Roest, AAW., van den Boogaard, PJ., Blom, NA., de Roos, A., Westenberg, JJM., Piatti, Filippo, Sturla, Francesco, Pirola, Selene, Votta, Emiliano, Nesteruk, Igor, Lombardi, Massimo, Corte, Alessandro Della, Bissell, Malenka, Caiani, Enrico Gianluca, Redaelli, Alberto, Berlot, B., Golfin, C. Fernandez, Hinojar, R., Esteban, A., Mendez, MA Fernandez, Megias, A., Gomez, A. Gonzalez, García, A., Alonso, G., Marco, A., Casas, E., Nacher, JJ. Jimenez, Zamorano, JL., Baggi, Chiara, Piatti, Filippo, Sturla, Francesco, Votta, Emiliano, Pluchinotta, Francesca, Lombardi, Massimo, Redaelli, Alberto, Hinojar, R., Golfin, C. Fernandez, Esteban, A., Mendez, MA Fernandez, Megias, A., Gonzalez Gomez, A., García, A., Alonso, G., Marco, A., Nacher, JJ. Jimenez, Zamorano, JL., McAlindon, Elisa, Dastidar, Amardeep, Bucciarelli-Ducci, Chiara, McAlindon, Elisa, Littlejohns, Ben, Suleiman, Saadeh, Baumbach, Andreas, Bucciarelli-Ducci, Chiara, McAlindon, Elisa, Vizzi, Vincenzo, Baumbach, Andreas, Bucciarelli-Ducci, Chiara, Tanaka, Kaoru, Fierens, Yves, Nijs, Jan, De Mey, Johan, Lai, Peng, Raeymaekers, Hubert, Elbaz, Mohammed S.M., Toger, Johannes, Heiberg, Einar, Westenberg, Jos J., Solana, Ana Beatriz, Hafalir, Fatih, Ghedin, Piero, Lai, Peng, Shimakawa, A., Anja, C., Fratz, Sohrab, McGill, Laura-Ann, Ferreira, Pedro, Scott, Andrew D, Nielles-Vallespin, Sonia, Giannakidis, Archontis, J Kilner, Philip, Gatehouse, Peter D, de Silva, Ranil, Firmin, David N, Pennell, Dudley J, Merten, Constanze, Beurich, Hans-Wilko, Zachow, Dirk, El-Mawardy, Mohamed, Abdel-Wahab, Mohamed, Richardt, Gert, Merten, Constanze, Beurich, Hans-Wilko, Zachow, Dirk, Abdel-Wahab, Mohamed, El-Mawardy, Mohamed, Tölg, Ralph, Richardt, Gert, De Garate, Estefania, Biglino, Giovanni, Aileen, Wilson, Dodd, James, Bucciarelli-Ducci, Chiara, Salinas, GL. Alonso, Gómez, A. González, Hinojar, R., Golfín, C. Fernández, Esteban, A., del Castillo, A. Marco, Monteagudo, J., Izco, M. Pascual, Megías, A., Martín, A. García, Nacher, JJ. Jiménez, Zamorano, JL, Dastidar, Amardeep Ghosh, Carpenter, Alexander, Rodrigues, Jonathan, Palazzuoli, Alberto, Wilson, Catherine, Kestenbaum, Samantha, Baritussio, Anna, Baumbach, Andreas, Nightingale, Angus, Bucciarelli-Ducci, Chiara, Dastidar, Amardeep Ghosh, Rodrigues, Jonathan, Szantho, Gergely, McAlindon, Elisa, Baritussio, Anna, Scatteia, Alessandra, De Garate, Estefania, Lawton, Chris Benny, Erdei, Tamas, Manghat, Nathan, Hamilton, Mark, Bucciarelli-Ducci, Chiara, Nazir, Sheraz A., Greenwood, John P., Shetye, Abhishek, Khan, Jamal N., Singh, Anvesha, Kanagala, Prathap, Swarbrick, Daniel, Gulsin, Gaurav, Graham-Brown, Matthew, Gershlick, Anthony, McCann, Gerry P., Pais, João, Picarra, Bruno, Santos, Ana Rita, Guerreiro, Rui, Congo, Kisa Hyde, Carvalho, João, Neves, David, and Aguiar, José

Abstract

Objectives: Myocardial fibrosis in noninfarcted myocardium is emerging as a principal phenotype of vulnerability to adverse events such as mortality and hospitalization for heart failure (HHF), but its optimal noninvasive measurement remains uncertain despite consistently robust histologic validation data for extracellular volume fraction (ECV). We therefore compared ECV, native T1, post contrast T1, the gadolinium contrast partition coefficient (lambda), and the presence of nonischemic scar in their associations with mortality and HHF outcomes. Method: To quantify of myocardial fibrosis, we performed T1 mapping (MOLLI) in basal and mid short axis slices with cardiovascular magnetic resonance (CMR) before contrast and 12-30 minutes post contrast bolus in 1185 consecutive patients without amyloidosis, hypertrophic or stress cardiomyopathy. We assessed associations with outcomes using Kaplan-Meier plots and chi square values from univariable Cox regression models. All standard T1 mapping parameters were obtained: native and post contrast myocardial T1, the partition coefficient lambda, and ECV. ECV = (1-hematocrit) · [ΔR1myocardium]/[ΔR1bloodpool], where R1 = 1/T1 Late gadolinium enhancement imaging with phase sensitive reconstruction identified nonischemic scar. Results: Over a median of 1.7 years, 111 individuals experienced events after CMR: 55 HHF events and 74 deaths. ECV yielded better separation of Kaplan-Meier curves in a dose dependent fashion (Figure) and also stronger associations with the combined endpoint of death or HHF. The ECV chi square (77.3, p < 0.001) was at least twice as large as the Native T1 chi square (37.5, p < 0.001), the lambda chi square (34.8, p < 0.001) and nonischemic scar (chi square = 20.5, p<0.001). Post-contrast T1 was not associated with outcomes, even when adjusting further for time after contrast bolus, renal function, and patient weight (chi square <3, p >0.10). Conclusion: Analogous to histologic previously published validation data, quantitative ECV myocardial fibrosis measures associated with outcomes far stronger than other surrogate measures outcome measures such as native T1, post contrast T1 and nonischemic scar on LGE images. These data suggest that ECV is the noninvasive metric of choice to measure myocardial fibrosis. Figure. Kaplan-Meier Plots for T1 mapping parameters.

Published
2016
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27. HIT Poster session 2

Author

Bucciarelli, V, Bianco, F, Izzicupo, P, Ghinassi, B, Di Baldassarre, A, Gallina, S, Avenatti, E, Milazzo, V, Milan, A, Patel, A, Kuvin, J, Pandian, N, Rosner, SJ, Orban, M, Nadjiri, J, Lesevic, H, Hadamitzky, M, Sonne, C, Cherneva, ZHCH, Kuneva, ZK, Vasilev, DV, Li, H, Yuan, L, Xie, MX, Jin, XY, Surkova, E A, Muraru, D, Grapsa, J, Donal, E, Lancellotti, P, Habib, G, Badano, L P, Degiovanni, A, Buffa, MC, De Vecchi, F, Prenna, E, Boggio, E, Marino, P, Ortiz Garrido, A, De La Chica, J, Cuenca Peiro, V, Picazo Angelin, B, Conejo Munoz, L, Narbona, I, Anderica, JR, De Mora, M, Zabala Arguelles, JI, Mihaila, S, Velcea, A, Matei, L, Andronic, A, Calin, S, Rimbas, R, Muraru, D, Badano, LP, Vinereanu, D, Tamulenaite, E, Ovsianas, J, Valuckiene, Z, Jurkevicius, R, Amorouayeche, F Z, Latreche, S, Benkhedda, S, Kolesnyk, M Y, Dzyak, G V, Riznyk, Y Y, Kovalyova, O V, Garcia Campos, A, Velasco-Alonso, E, Colunga-Blanco, S, Martin-Fernandez, M, Corros-Vicente, C, Rodriguez-Suarez, ML, Leon-Aguero, V, De La Hera Galarza, JM, Savcioglu, AS, Safak, O, Nazli, C, Akyildiz Akcay, F, Yakar Tuluce, S, Kahya Eren, N, Ozdemir, E, Kocabas, U, Filipiak, D, Kasprzak, JD, Lipiec, P, Kuusisto, J K, Jarvinen, VM, Sinisalo, JP, Torbas, O, Sirenko, YU, Radchenko, G, Rekovets, O, Kushnir, S, Kupczynska, K, Michalski, BW, Miskowiec, D, Kasprzak, JD, Wdowiak-Okrojek, K, Wejner-Mik, P, Lipiec, P, Tountas, X, Beldekos, D, Protogerou, A, Gournizakis, A, Panopoulos, S, Theodosis-Georgilas, A, Fousas, S, Sfikakis, P, Ionin, VA, Soboleva, AV, Listopad, OV, Nifontov, SE, Polyakova, EA, Belyaeva, OD, Baranova, EI, Shlyachto, EV, Cescau, A, Baudet, M, Cohen-Solal, A, Logeart, D, Altin, C, Sakallioglu, O, Aydin, E, Yilmaz, M, Sade, LE, Muderrisoglu, H, Ferreiro Quero, C, Mesa Rubio, M D, Ruiz Ortiz, M, Delgado Ortega, M, Sanchez Fernandez, J, Duran Jimenez, E, Morenate Navio, C, Romero, M, Pan, M, Suarez De Lezo, J, Lowery, C, Frenneaux, M P, Parasuraman, S K, Rudd, A E, Srinivasan, J, Najih, H, Elbaghdadi, D, Laarej, A, Allouch, M, Azzouzi, L, Habbal, R, Valuckiene, Z, Ovsianas, J, Mizariene, V, Ablonskyte-Dudoniene, R, Jurkevicius, R, Onciul, S, Cucchini, U, Miglioranza, MH, Dorobantu, M, Iliceto, S, Badano, LP, Muraru, D, Yang, L-T, Tsai, WC, Baricevic, Z, Cikes, M, Ljubas Macek, J, Skoric, B, Skorak, I, Jurin, H, Samardzic, J, Gasparovic, H, Milicic, D, Separovic Hanzevacki, J, Ghulam Ali, S, Fusini, L, Tamborini, G, Gripari, P, Muratori, M, Celeste, F, Carminati, MC, Alamanni, F, and Pepi, M

Abstract

Background: Menopause is associated with worsening of cardiovascular (CV) risk factors that can be counteract by physical exercise. Between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism, the deletion variant (DD) is related to higher levels of circulating angiotensin II. We evaluated the effect of a short term endurance exercise program on CV remodeling, by means of 2-D echocardiography, among healthy, sedentary, postmenopausal women with ACE I/D genotypes. Methods: Fifty-three women (mean age 56 ± 4 years) underwent a 4 months moderate intensity walking training, eliciting an effort equal to 11-12 according the rating of perceived exertion scale (RPE). Partecipants' attendance at physical exercise program was 85.90 ± 10.75%. The ACE genotype was ascertained by polimerase chain reaction (DD in 20; ID in 27) before (T0) and after training (T1), along with laboratory, anthropometric and echocardiographic measurements. Results: We observed in both groups a significant reduction in systolic and diastolic blood pressure, weight and body mass index, along with a significant increase in left ventricular ejection fraction and diastolic function. Only ID group showed a significant decrease in heart rate and relative wall thickness [RWT ± SD] (T0 0.42 ± 0.06 – T1 0.40 ± 0.05, P 0.04), with a significant increase in left ventricular mass index [LVMI, g/m(2.7) ± SD] (T0 44.58 ± 11.28 – T1 47.34 ± 9.94, P 0.004) and in right ventricular systolic function, assessed by tricuspid annular plane systolic excursion [TAPSE, mm ± SD] (T0 22.52 ± 0.3 – T1 22.96 ± 0.3, P 0.03). Conclusions: Short term aerobic exercise program ameliorates CV profile in healthy, sedentary, postmenopausal women and is associated with positive left ventricular remodeling in ID patients. Enhanced ACE activity, as in DD genotype, could reduce this phenomenon. Thus, ACE polymorphism could account for the individual cardiac remodeling response to physical exercise and should be considered in order to optimize CV prevention measures.

Published
2015
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28. Poster session 2: Thursday 4 December 2014, 08:30-12:30 * Location: Poster area

Author

Domingos, JS, Augustine, DX, Leeson, P, Noble, JA, Doan, H-L, Boubrit, L, Cheikh-Khalifa, R, Laveau, F, Djebbar, M, Pousset, F, Isnard, R, Hammoudi, N, Lisi, M, Cameli, M, Di Tommaso, C, Curci, V, Reccia, R, Maccherini, M, Henein, M Y, Mondillo, S, Leitman, M, Vered, Z, Rashid, H, Yalcin, M U, Gurses, K M, Kocyigit, D, Evranos, B, Yorgun, H, Sahiner, L, Kaya, B, Aytemir, K, Ozer, N, Bertella, E, Petulla', M, Baggiano, A, Mushtaq, S, Russo, E, Gripari, P, Innocenti, E, Andreini, D, Tondo, C, Pontone, G, Necas, J, Kovalova, S, Hristova, K, Shiue, I, Bogdanva, V, Teixido Tura, G, Sanchez, V, Rodriguez-Palomares, J, Gutierrez, L, Gonzalez-Alujas, T, Garcia-Dorado, D, Forteza, A, Evangelista, A, Timoteo, A T, Aguiar Rosa, S, Cruz Ferreira, R, Campbell, R, Carrick, D, Mccombe, C, Tzemos, N, Berry, C, Sonecki, P, Noda, M, Setoguchi, M, Ikenouchi, T, Nakamura, T, Yamamoto, Y, Murakami, T, Katou, Y, Usui, M, Ichikawa, K, Isobe, M, Kwon, BJ, Roh, JW, Kim, HY, Ihm, SH, Barron, A J, Francis, DP, Mayet, J, Wensel, R, Kosiuk, J, Dinov, B, Bollmann, A, Hindricks, G, Breithardt, OA, Rio, P, Moura Branco, L, Galrinho, A, Cacela, D, Pinto Teixeira, P, Afonso Nogueira, M, Pereira-Da-Silva, T, Abreu, J, Teresa Timoteo, A, Cruz Ferreira, R, Pavlyukova, EN, Tereshenkova, EK, Karpov, RS, Piatkowski, R, Kochanowski, J, Opolski, G, Barbier, P, Mirea, O, Guglielmo, M, Savioli, G, Cefalu, C, Pudil, R, Horakova, L, Rozloznik, M, Balestra, C, P37/03, PRVOUK, Rimbas, RC, Enescu, OA, Calin, S, Vinereanu, D, POSDRU/159/1.5/S/141531, Grant, Karsenty, C, Hascoet, S, Hadeed, K, Semet, F, Dulac, Y, Alacoque, X, Leobon, B, Acar, P, Dharma, S, Sukmawan, R, Soesanto, AM, Vebiona, KPP, Firdaus, I, Danny, SS, Driessen, M M P, Sieswerda, GTJ, Post, MC, Snijder, RJ, Van Dijk, APJ, Leiner, T, Meijboom, FJ, Chrysohoou, C, Tsitsinakis, G, Tsiachris, D, Aggelis, A, Herouvim, E, Vogiatzis, I, Pitsavos, C, Koulouris, G, Stefanadis, C, Erdei, T, Edwards, J, Braim, D, Yousef, Z, Fraser, AG, Cardiff, Investigators, MEDIA, Avenatti, E, Magnino, C, Omede', P, Presutti, D, Moretti, C, Iannaccone, A, Ravera, A, Gaita, F, Milan, A, Veglio, F, Barbier, P, Scali, MC, Simioniuc, A, Guglielmo, M, Savioli, G, Cefalu, C, Mirea, O, Fusini, L, Dini, F, Okura, H, Murata, E, Kataoka, T, Mikaelpoor, A, Ojaghi Haghighi, SH, Ojaghi Haghighi, SZ, Alizadeasl, A, Sharifi-Zarchi, A, Zaroui, A, Ben Halima, M, Mourali, MS, Mechmeche, R, Rodriguez Palomares, J F, Gutierrez, LG, Maldonado, GM, Garcia, GG, Otaegui, IO, Garcia Del Blanco, BGB, Teixido, GT, Gonzalez Alujas, MTGA, Evangelista, AE, Garcia Dorado, DGD, Godinho, A R, Correia, AS, Rangel, I, Rocha, A, Rodrigues, J, Araujo, V, Almeida, PB, Macedo, F, Maciel, MJ, Rekik, B, Mghaieth, F, Aloui, H, Boudiche, S, Jomaa, M, Ayari, J, Tabebi, N, Farhati, A, Mourali, S, Dekleva, M, Markovic-Nikolic, N, Zivkovic, M, Stankovic, A, Boljevic, D, Korac, N, Beleslin, B, Arandjelovic, A, Ostojic, M, Galli, E, Guirette, Y, Auffret, V, Daudin, M, Fournet, M, Mabo, P, Donal, E, Chin, C W L, Luo, E, Hwan, J, White, A, Newby, D, Dweck, M, Carstensen, H G, Larsen, L H, Hassager, C, Kofoed, K F, Jensen, J S, Mogelvang, R, Kowalczyk, M, Debska, M, Kolesnik, A, Dangel, J, Kawalec, W, Migliore, RA, Adaniya, ME, Barranco, MA, Miramont, G, Gonzalez, S, Tamagusuku, H, Davidsen, E S, Kuiper, K K J, Matre, K, Gerdts, E, Igual Munoz, B, Maceira Gonzalez, AMG, Erdociain Perales, MEP, Estornell Erill, JEE, Valera Martinez, FVM, Miro Palau, VMP, Piquer Gil, MPG, Sepulveda Sanchez, PSS, Cervera Zamora, ACZ, Montero Argudo, AMA, Placido, R, Silva Marques, J, Magalhaes, A, Guimaraes, T, Nobre E Menezes, M, Goncalves, S, Ramalho, A, Robalo Martins, S, Almeida, AG, Nunes Diogo, A, Abid, L, Ben Kahla, S, Charfeddine, S, Abid, D, Kammoun, S, Tounsi, A, Abid, LEILA, Abid, DORRA, Charfeddine, SALMA, Hammami, RANIA, Triki, FETEN, Akrout, MALEK, Mallek, SOUAD, Hentati, MOURAD, Kammoun, SAMIR, Sirbu, C F, Berrebi, A, Huber, A, Folliguet, T, Yang, L-T, Shih, JY, Liu, YW, Li, YH, Tsai, LM, Luo, CY, Tsai, WC, Babukov, R, Bartosh, F, Bazilev, V, Muraru, D, Cavalli, G, Addetia, K, Miglioranza, MH, Veronesi, F, Mihaila, S, Tadic, M, Cucchini, U, Badano, L, Lang, RM, Miyazaki, S, Slavich, M, Miyazaki, T, Figini, F, Lativ, A, Chieffo, A, Montrfano, M, Alfieri, O, Colombo, A, Agricola, E, Liu, D, Hu, K, Herrmann, S, Stoerk, S, Kramer, B, Ertl, G, Bijnens, B, Weidemann, F, Brand, M, Butz, T, Tzikas, S, Van Bracht, M, Roeing, J, Wennemann, R, Christ, M, Grett, M, Trappe, H-J, Scherzer, S, Geroldinger, AG, Krenn, L, Roth, C, Gangl, C, Maurer, G, Rosenhek, R, Neunteufl, T, Binder, T, Bergler-Klein, J, Martins, E, Pinho, T, Leite, S, Azevedo, O, Belo, A, Campelo, M, Amorim, S, Rocha-Goncalves, F, Goncalves, L, Silva-Cardoso, J, Ahn, HS, Kim, KT, Jeon, HK, Youn, HJ, Haland, T, Saberniak, J, Leren, IS, Edvardsen, T, Haugaa, KH, Ziolkowska, L, Boruc, A, Kowalczyk, M, Turska-Kmiec, A, Zubrzycka, M, Kawalec, W, Monivas Palomero, V, Mingo Santos, S, Goirigolzarri Artaza, J, Rodriguez Gonzalez, E, Rivero Arribas, B, Castro Urda, V, Dominguez Rodriguez, F, Mitroi, C, Gracia Lunar, I, Fernadez Lozano, I, Palecek, T, Masek, M, Kuchynka, P, Fikrle, M, Spicka, I, Rysava, R, Linhart, A, Saberniak, J, Hasselberg, NE, Leren, IS, Haland, T, Borgquist, R, Platonov, PG, Edvardsen, T, Haugaa, KH, Ancona, R, Comenale Pinto, S, Caso, P, Coopola, MG, Arenga, F, Rapisarda, O, D'onofrio, A, Sellitto, V, Calabro, R, Rosca, M, Popescu, BA, Calin, A, Mateescu, A, Beladan, CC, Jalba, M, Rusu, E, Zilisteanu, D, Ginghina, C, Pressman, G, Cepeda-Valery, B, Romero-Corral, A, Moldovan, R, Saenz, A, Orban, M, Samuel, SP, Fijalkowski, M, Fijalkowska, M, Gilis-Siek, N, Blaut, K, Galaska, R, Sworczak, K, Gruchala, M, Fijalkowski, M, Nowak, R, Gilis-Siek, N, Fijalkowska, M, Galaska, R, Gruchala, M, Ikonomidis, I, Triantafyllidi, H, Trivilou, P, Tzortzis, S, Papadopoulos, C, Pavlidis, G, Paraskevaidis, I, Lekakis, J, Padiyath, A, Li, L, Xiao, Y, Danford, DA, Kutty, S, Kaymaz, C, Aktemur, T, Poci, N, Ozturk, S, Akbal, O, Yilmaz, F, Tokgoz Demircan, HC, Kirca, N, Tanboga, IH, Ozdemir, N, Investigators, EUPHRATES, Greiner, S, Jud, A, Aurich, M, Hess, A, Hilbel, T, Hardt, S, Katus, HA, D'ascenzi, F, Cameli, M, Alvino, F, Lisi, M, Focardi, M, Solari, M, Bonifazi, M, Mondillo, S, Konopka, M, Krol, W, Klusiewicz, A, Burkhard, K, Chwalbinska, J, Pokrywka, A, Dluzniewski, M, Braksator, W, King, G J, Coen, K, Gannon, S, Fahy, N, Kindler, H, Clarke, J, Iliuta, L, Rac-Albu, M, Placido, R, Robalo Martins, S, Guimaraes, T, Nobre E Menezes, M, Cortez-Dias, N, Francisco, A, Silva, G, Goncalves, S, Almeida, AG, Nunes Diogo, A, Kyu, K, Kong, WKF, Songco, GG, Galupo, MJ, Castro, MD, Shin Hnin, W, Ronald Lee, CH, Poh, KK, Milazzo, V, Di Stefano, C, Tosello, F, Leone, D, Ravera, A, Sabia, L, Sobrero, G, Maule, S, Veglio, F, Milan, A, Jamiel, A M, Ahmed, A M, Farah, I, Al-Mallah, M H, Petroni, R, Magnano, R, Bencivenga, S, Di Mauro, M, Petroni, S, Altorio, SF, Romano, S, Penco, M, Kumor, M, Lipczynska, M, Klisiewicz, A, Wojcik, A, Konka, M, Kozuch, K, Szymanski, P, Hoffman, P, Rimbas, RC, Rimbas, M, Enescu, OA, Mihaila, S, Calin, S, Vinereanu, D, 112/2011, Grant CNCSIS, 159/1.5/S/141531, Grant POSDRU, Donal, E, Reynaud, A, Lund, LH, Persson, H, Hage, C, Oger, E, Linde, C, Daubert, JC, investigators, KaRen, Maria Oliveira Lima, M, Costa, H, Gomes Da Silva, M, Noman Alencar, MC, Carmo Pereira Nunes, M, Costa Rocha, MO, Abid, L, Charfeddine, S, Ben Kahla, S, Abid, D, Siala, A, Hentati, M, Kammoun, S, Kovalova, S, Necas, J, Ozawa, K, Funabashi, N, Takaoka, H, Kobayashi, Y, Matsumura, Y, Wada, M, Hirakawa, D, Yasuoka, Y, Morimoto, N, Takeuchi, H, Kitaoka, H, Sugiura, T, Lakkas, L, Naka, KK, Ntounousi, E, Gkirdis, I, Koutlas, V, Bechlioulis, A, Pappas, K, Katsouras, CS, Siamopoulos, K, Michalis, LK, Naka, KK, Evangelou, D, Kalaitzidis, R, Bechlioulis, A, Lakkas, L, Gkirdis, I, Tzeltzes, G, Nakas, G, Katsouras, CS, Michalis, LK, Generati, G, Bandera, F, Pellegrino, M, Labate, V, Alfonzetti, E, Guazzi, M, Zagatina, A, Zhuravskaya, N, Al-Mallah, M, Alsaileek, A, Qureshi, W, Karsenty, C, Hascoet, S, Peyre, M, Hadeed, K, Alacoque, X, Amadieu, R, Leobon, B, Dulac, Y, Acar, P, Yamanaka, Y, Sotomi, Y, Iwakura, K, Inoue, K, Toyoshima, Y, Tanaka, K, Oka, T, Tanaka, N, Orihara, Y, Fujii, K, Soulat-Dufour, L, Lang, S, Boyer-Chatenet, L, Van Der Vynckt, C, Ederhy, S, Adavane, S, Haddour, N, Boccara, F, Cohen, A, Huitema, MP, Boerman, S, Vorselaars, VMM, Grutters, JC, Post, MC, Gopal, A S, Saha, SK, Toole, RS, Kiotsekoglou, A, Cao, JJ, Reichek, N, Meyer, C G, Altiok, E, Al Ateah, G, Lehrke, M, Becker, M, Lotfi, S, Autschbach, R, Marx, N, Hoffmann, R, Frick, M, Nemes, A, Sepp, R, Kalapos, A, Domsik, P, Forster, T, Caro Codon, J, Blazquez Bermejo, Z, Lopez Fernandez, T, Valbuena Lopez, S C, Iniesta Manjavacas, A M, De Torres Alba, F, Dominguez Melcon, F, Pena Conde, L, Moreno Yanguela, M, Lopez-Sendon, J L, Nemes, A, Lengyel, C, Domsik, P, Kalapos, A, Orosz, A, Varkonyi, TT, Forster, T, Rendon, J, Saldarriaga, C I, Duarte, N, Nemes, A, Domsik, P, Kalapos, A, Forster, T, Nemes, A, Domsik, P, Kalapos, A, Sepp, R, Foldeak, D, Borbenyi, Z, Forster, T, Hamdy, AM, Fereig, HM, Nabih, MA, Abdel-Aziz, A, Ali, AA, Broyd, CJ, Wielandts, J-Y, De Buck, S, Michielsen, K, Louw, R, Garweg, C, Nuyts, J, Ector, J, Maes, F, Heidbuchel, H, Gillis, K, Bala, G, Tierens, S, Cosyns, B, Maurovich-Horvat, P, Horvath, T, Jermendy, A, Celeng, C, Panajotu, A, Bartykowszki, A, Karolyi, M, Tarnoki, AD, Jermendy, G, and Merkely, B

Abstract

Purpose: 3D echocardiography (3DE) enables fast 3D acquisition but subsequent manual navigation to find 2D diagnostic planes can be time consuming. We have developed and validated an automated machine learning-based technique to find apical 2-, 3- and 4-chamber (A2C, A3C, A4C) views that enables fast volume navigation and analysis. Methods: 3DE volumes were acquired (Philips iE33: X3-1 and X5-1 probes) from 30 healthy volunteers and 36 clinical patients with suspected valve disease and coronary heart disease. 66 end diastolic volumes were used to assess the accuracy of apical standard view finding by our method against manual plane finding. To do this, dedicated software was developed with a machine learning approach and a 3-fold cross validation of results was performed. Results: Automatic A4C view detection was possible in 60/66 (91%) of volumes; detection failures were due to suboptimal myocardium wall integrity or lack of right ventricle in the scan. A2C and A3C views were extracted from the A4C view using the known geometrical relationships between apical standard views (A2C to A3C: 30°~40° and A2C to A4C: 90° of rotation over the left ventricle long axis, as shown in the Figure). In average, our method accurately found the heart apex and mitral valve centre with a 7.1 ± 5.7 mm and 7.2 ± 5.3 mm error, respectively. Conclusions: In order to automate clinical workflow, we have developed a new and fully automatic machine learning strategy for apical standard view finding which performed well (91% detection accuracy) on volunteer and clinical 3D echocardiograms. Figure

Published
2014
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29. Poster session 5: Friday 5 December 2014, 14:00-18:00 * Location: Poster area

Author

Turco, A, Duchenne, J, Nuyts, J, Gheysens, O, Voigt, J-U, Claus, P, Vunckx, K, Muhtarov, K, Ozer, N, Turk, G, Sunman, H, Karakulak, U, Sahiner, L, Kaya, B, Yorgun, H, Hazirolan, T, Aytemir, K, Warita, S, Kawasaki, M, Tanaka, R, Houle, H, Yagasaki, H, Nagaya, M, Ono, K, Noda, T, Watanabe, S, Minatoguchi, S, Kyle, AS, Dauphin, C, Lusson, J R, Dragoi Galrinho, R, Rimbas, RC, Ciobanu, AO, Marinescu, B, Cinteza, M, Vinereanu, D, 28343/04.11.2013, number, Medicine, Funding Authority: University of, Davila, Pharmacy Carol, "Young Researchers" Projects – 2013, Buchar, Dragoi Galrinho, R, Ciobanu, AO, Rimbas, RC, Marinescu, B, Cinteza, M, Vinereanu, D, 159/1.5/S/138907, Grant POSDRU, Aparina, O, Stukalova, O, Butorova, E, Makeev, M, Bolotova, M, Parkhomenko, D, Golitsyn, SP, Zengin, E, Hoffmann, B A, Ramuschkat, M, Ojeda, F, Weiss, C, Willems, S, Blankenberg, S, Schnabel, R B, Sinning, C R, Schubert, U, Suhai, F I, Toth, A, Kecskes, K, Czimbalmos, CS, Csecs, I, Maurovich-Horvat, P, Simor, T, Merkely, B, Vago, H, Slawek, D, Chrzanowski, L, Krecki, R, Binkowska, A, Kasprzak, J D, Palombo, C, Morizzo, C, Kozakova, M, Biering-Sorensen, T, Mogelvang, R, Jensen, JS, Charisopoulou, DC, Koulaouzidis, GK, Rydberg, AR, Henein, MH, Kovacs, A, Olah, A, Lux, A, Matyas, C, Nemeth, BT, Kellermayer, D, Ruppert, M, Birtalan, E, Merkely, B, Radovits, T, Sengelov, M, Biering-Sorensen, T, Jorgensen, PG, Bruun, NE, Fritz-Hansen, T, Bech, J, Olsen, FJ, Sivertsen, J, Jensen, JS, Henri, C, Dulgheru, R, Magne, J, Kou, S, Davin, L, Nchimi, A, Oury, C, Pierard, L, Lancellotti, P, Sahin, S T, Cengiz, B, Yurdakul, S, Altuntas, E, Aytekin, V, Aytekin, S, Bajraktari, G, Ibrahimi, P, Bytyci, I, Ahmeti, A, Batalli, A, Elezi, S, Henein, MY, Pavlyukova, EN, Tereshenkova, EK, Karpov, RS, Barbier, P, Mirea, O, Guglielmo, M, Savioli, G, Cefalu, C, Maltagliati, MC, Tumasyan, LR, Adamyan, KG, Chilingaryan, AL, Tunyan, LG, Kowalik, E, Klisiewicz, A, Biernacka, EK, Hoffman, P, Park, CS, Yi, JEY, Cho, JSC, Ihm, SHI, Kim, HYK, Cho, EJC, Jeon, HKJ, Jung, HOJ, Youn, HJY, Mcghie, JS, Menting, ME, Vletter, WB, Roos-Hesselink, JW, Geleijnse, ML, Van Der Zwaan, H, Van Den Bosch, A, Spethmann, S, Baldenhofer, G, Stangl, V, Baumann, G, Stangl, K, Laule, M, Dreger, H, Knebel, F, Erdei, T, Edwards, J, Braim, D, Yousef, Z, Fraser, AG, Cardiff, Investigators, MEDIA, Keramida, K, Kouris, N, Kostopoulos, V, Kostakou, P, Petrogiannos, CH, Olympios, CD, Bajraktari, G, Berisha, G, Bytyci, I, Ibrahimi, P, Rexhepaj, N, Henein, MY, Wdowiak-Okrojek, K, Shim, A, Wejner-Mik, P, Szymczyk, E, Michalski, B, Kasprzak, JD, Lipiec, P, Tarr, A, Stoebe, S, Pfeiffer, D, Hagendorff, A, Haykal, M, Ryu, SK, Park, JY, Kim, SH, Choi, JW, Goh, CW, Byun, YS, Choi, JH, Sonoko, M, Onishi, T, Fujimoto, W, Yamada, S, Taniguchi, Y, Yasaka, Y, Kawai, H, Okura, H, Sakamoto, Y, Murata, E, Kanai, M, Kataoka, T, Kimura, T, Watanabe, N, Kuriyama, N, Nakama, T, Furugen, M, Sagara, S, Koiwaya, H, Ashikaga, K, Matsuyama, A, Shibata, Y, Meimoun, P, Abouth, S, Martis, S, Boulanger, J, Elmkies, F, Zemir, H, Tzvetkov, B, Luycx-Bore, A, Clerc, J, Galli, E, Oger, E, Guirette, Y, Daudin, M, Fournet, M, Donal, E, Galli, E, Guirette, Y, Mabo, P, Donal, E, Keramida, K, Kouris, N, Kostopoulos, V, Psarrou, G, Petrogiannos, CH, Hatzigiannis, P, Olympios, CD, Igual Munoz, B, Erdociain Perales, MEP, Maceira Gonzalez Alicia, AMG, Vazquez Sanchez, ALEJAN, Miro Palau, VMP, Alonso Fernandez, PAF, Donate Bertolin, LDB, Estornell Erill, JEE, Cervera, AC, Montero Argudo Anastasio, AMA, Okura, H, Koyama, T, Maehama, T, Imai, K, Yamada, R, Kume, T, Neishi, Y, Caballero Jimenez, L, Garcia-Navarro, M, Saura, D, Oliva, MJ, Gonzalez-Carrillo, J, Espinosa, MD, Valdes, M, De La Morena, G, Venkateshvaran, A, Sola, S, Dash, P K, Annappa, C, Manouras, A, Winter, R, Brodin, LA, Govind, S C, Laufer-Perl, LM, Topilsky, Y, Stugaard, M, Koriyama, H, Katsuki, K, Masuda, K, Asanuma, T, Takeda, Y, Sakata, Y, Nakatani, S, Marta, L, Abecasis, J, Reis, C, Dores, H, Cafe, H, Ribeiras, R, Andrade, MJ, Mendes, M, Goebel, B, Hamadanchi, A, Schmidt-Winter, C, Otto, S, Jung, C, Figulla, HR, Poerner, TC, Kim, D-H, Sun, BJ, Jang, JY, Choi, HN, Song, J-M, Kang, D-H, Song, J-K, Zakhama, L, Slama, I, Boussabah, E, Antit, S, Herbegue, B, Annabi, MS, Jalled, A, Ben Ameur, W, Thameur, M, Ben Youssef, S, O' Grady, H, Gilmore, M, Delassus, P, Sturmberger, T, Ebner, C, Aichinger, J, Tkalec, W, Eder, V, Nesser, HJ, Caggegi, A M, Scandura, S, Capranzano, P, Grasso, C, Mangiafico, S, Ronsivalle, G, Dipasqua, F, Arcidiacono, A, Cannata, S, Tamburino, C, Chapman, M, Henthorn, RENEE, Surikow, S, Zoontjens, J, Stocker, B, Mclean, T, Zeitz, C J, Fabregat Andres, O, Estornell-Erill, J, Ridocci-Soriano, F, De La Espriella, R, Albiach-Montanana, C, Trejo-Velasco, B, Perdomo-Londono, D, Facila, L, Morell, S, Cortijo-Gimeno, J, Kouris, N, Keramida, K, Kostopoulos, V, Psarrou, G, Kostakou, P, Olympios, CD, Kuperstein, R, Blechman, I, Freimatk, D, Arad, M, Ochoa, J P, Fernandez, A, Vaisbuj, F, Salmo, F, Fava, AM, Casabe, H, Guevara, EG, Fernandes, A, Cateano, F, Almeida, I, Silva, J, Trigo, J, Botelho, A, Sanches, C, Venancio, M, Goncalves, L, Schnell, F, Daudin, M, Oger, E, Bouillet, P, Mabo, P, Carre, F, Donal, E, Petrella, L, Fabiani, D, Paparoni, S, De Remigis, F, Tomassoni, G, Prosperi, F, Napoletano, C, Marchel, M, Serafin, A, Kochanowski, J, Steckiewicz, R, Madej-Pilarczyk, A, Filipiak, KJ, Opolski, G, Abid, L, Ben Kahla, S, Charfeddine, S, Kammoun, S, Monivas Palomero, V, Mingo Santos, S, Goirigoizarri Artaza, J, Rodriguez Gonzalez, E, Restrepo Cordoba, A, Rivero Arribas, B, Garcia Lunar, I, Gomez Bueno, M, Sayago Silva, I, Segovia Cubero, J, Zengin, E, Radunski, U K, Klusmeier, M, Ojeda, F, Rybczynski, M, Barten, M, Muellerleile, K, Reichenspurner, H, Blankenberg, S, Sinning, C R, Romano, G, Licata, P, Tuzzolino, F, Clemenza, F, Di Gesaro, G, Hernandez Baravoglia, C, Scardulla, C, Pilato, M, Hashimoto, G, Suzuki, M, Yoshikawa, H, Otsuka, T, Isekame, Y, Iijima, R, Hara, H, Nakamura, M, Sugi, K, Melnikova, MA, Krestjyaninov, MV, Ruzov, VI, Magnino, C, Omede', P, Avenatti, E, Presutti, D, Moretti, C, Ravera, A, Sabia, L, Gaita, F, Veglio, F, Milan, A, Magda, SL, Mincu, RI, Soare, A, Mihai, CM, Florescu, M, Mihalcea, D, Cinteza, M, Vinereanu, D, POSDRU/159/1.5/S/141531, Grant, 112/2011, grant CNCSIS, Chatzistamatiou, E, Mpampatseva Vagena, I, Manakos, K, Moustakas, G, Konstantinidis, D, Memo, G, Mitsakis, O, Kasakogias, A, Syros, P, Kallikazaros, I, Petroni, R, Acitelli, A, Cicconetti, M, Di Mauro, M, Altorio, SF, Romano, S, Petroni, A, Penco, M, Apostolovic, S, Stanojevic, D, Jankovic-Tomasevic, R, Salinger-Martinovic, S, Pavlovic, M, Djordjevic-Radojkovic, D, Tahirovic, E, Dungen, HD, ELD, CIBIS, Jung, I H, Byun, Y S, Goh, C W, Kim, B O, Rhee, K J, Lee, D S, Kim, M J, Seo, H S, Kim, H Y, Tsverava, M, Tsverava, D, Zaletova, T, Shamsheva, D, Parkhomenko, O, Bogdanov, A, Derbeneva, S, Leotescu, A, Tudor, I, Gurghean, A, Bruckner, I, Plaskota, KJ, Trojnarska, O, Bartczak, A, Grajek, S, Sharma, P, Sharma, D, Garg, S, Vazquez Lopez-Ibor, J, Monivas Palomero, V, Solano-Lopez, JM, Zegri Reiriz, I, Dominguez Rodriguez, F, Gonzalez Mirelis, J, Mingo Santos, S, Sayago, I, Garcia Pavia, P, Segovia Cubero, J, Konecny, T, Noseworthy, P, Kapa, S, Cooper, LT, Mulpuru, SK, Asirvatham, S, Florescu, M, Mihalcea, D, Magda, S, Radu, E, Chirca, A, Acasandrei, AM, Jinga, D, Mincu, R, Enescu, OA, Vinereanu, D, 112/2011, no., PN-II-ID-PCE-2011-3-0791, Saura Espin, D, Caballero Jimenez, L, Oliva Sandoval, MJ, Gonzalez Carrillo, J, Garcia Navarro, M, Espinosa Garcia, MD, Valdes Chavarri, M, De La Morena Valenzuela, G, Abul Fadl, AAM, Mourad, MM, team, Primary care Echocardiography, Campanale, C M, Di Maria, S, Mega, S, Nusca, A, Marullo, F, Di Sciascio, G, Pardo Gonzalez, L, Delgado, M, Ruiz, M, Rodriguez, S, Hidalgo, F, Ortega, R, Mesa, D, Suarez De Lezo Cruz Conde, J, Bengrid, T M, Zhao, Y, Henein, MY, Kenjaev, S, Alavi, AL, Kenjaev, ML, Mendes, LM, Lima, S, Dantas, C, Melo, I, Madeira, V, Balao, S, Alves, H, Baptista, E, Mendes, P, Santos, JF, Scali, MC, Mandoli, GE, Simioniuc, A, Massaro, F, Di Bello, V, Marzilli, M, Dini, FL, Cifra, B, Dragulescu, A, Friedberg, MK, Mertens, L, Scali, MC, Bayramoglu, A, Tasolar, H, Otlu, YO, Hidayet, S, Kurt, F, Dogan, A, Pekdemir, H, Stefani, L, Galanti, GG, De Luca, ADL, Toncelli, LT, Pedrizzetti, GP, Gopal, A S, Saha, SK, Toole, RS, Kiotsekoglou, A, Cao, JJ, Reichek, N, Ho, S-J, Hung, S-C, Chang, F-Y, Liao, J-N, Niu, D-M, Yu, W-C, Nemes, A, Kalapos, A, Domsik, P, Forster, T, Siarkos, M, Sammut, E, Lee, L, Jackson, T, Carr-White, G, Rajani, R, Kapetanakis, S, Jarvinen, VM, Sipola, P, Madeo, A, Piras, P, Evangelista, A, Giura, G, Dominici, T, Nardinocchi, P, Varano, V, Chialastri, C, Puddu, PE, Torromeo, C, Sanchis Ruiz, L, Montserrat, S, Obach, V, Cervera, A, Bijnens, B, Sitges, M, Charisopoulou, D, Banner, N R, Rahman-Haley, S, Kim, BJ, Kang, JG, Lee, SH, Sung, KC, Kim, BS, Kang, JH, Lee, ES, Imperadore, F, Del Greco, M, Jermendy, AL, Horcsik, DV, Horvath, T, Celeng, C, Nagy, E, Bartykowszki, A, Tarnoki, DL, Merkely, B, Maurovich-Horvat, P, Jermendy, G, Whitaker, J, Demir, OM, Walton, J, Wragg, A, Alfakih, K, Karolyi, M, Szilveszter, B, Raaijmakers, R, Giepmans, W, Horvath, T, Merkely, B, Maurovich-Horvat, P, Koulaouzidis, GK, Charisopoulou, DC, Mcarthur, TM, Jenkins, PJJ, Henein, MH, Silva, T, Ramos, R, Oliveira, M, Marques, H, Cunha, P, Silva, MN, Barbosa, C, Sofia, A, Pimenta, R, Ferreira, RC, Al-Mallah, M, and Alsaileek, A

Abstract

Clinical PET acquisitions of the heart suffer from artefacts and drops in image quality due to the poor spatial resolution of the PET system. Moreover, cardiac PET images are further degraded by the blur caused by the breathing and beating motions, thus hampering diagnosis and evaluation of myocardial pathologies. Anatomy-enhanced PET reconstruction, using a high-resolution CT, has proven useful in brain imaging. In cardiac datasets however, due to the motion artefacts, the application of any restoring technique on datasets affected by motion blur needs to be preceded by the validation of the proposed method on realistic static datasets. In this work, the validation is performed using static cardiac ex vivo datasets obtained from a number of sacrificed sheep, scanned on a clinical PET/CT scanner. The aim of this work is to assess the effectiveness of reconstructions of the acquired datasets with different CT-based anatomical priors, in comparison to reconstructions currently applied in clinical practise. The gold standard to which all reconstructions are compared consists of images of the same hearts scanned on a small-animal PET scanner, whose high spatial resolution allows for almost artefact-free images. Encouraging results were obtained so far, with improvements in volume delineation and uniformity of activity values when anatomical information was used. Fig 1 shows the gold standard image (left) compared to a regular clinical reconstruction (middle) and to a reconstruction using the high-resolution CT as anatomical information (right). Figure

Published
2014
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30. MODERATED POSTER SESSION: Diseases impact on left ventricular function: Friday 5 December 2014, 08:30-18:00 * Location: Moderated Poster area

Author

Rangel, I, Goncalves, A, Sousa, C, Almeida, PB, Rodrigues, J, Macedo, F, Silva-Cardoso, J, Maciel, MJ, Adam, D, Khamis, H, Friedman, Z, Smirin, N, Hagendorff, A, Shimoni, S, Georgievska-Ismail, L, Hristovski, Z, Projevska-Donegati, D, Berezin, A, Kremzer, A, Samura, T, Berezina, T, Ternacle, J, Bodez, D, Guellich, A, Rappeneau, S, Dubois-Rande, J-L, Tissot, C-M, Hittinger, L, Plante-Bordeneuve, V, Deux, J-F, Damy, T, Gillebert, T C, Chirinos, J A, Rietzschel, E R, Shiva-Kumar, P, De Buyzere, M L, Zamani, P, Claessens, T C, Akers, S R, De Bacquer, D, Segers, P, Investigators, The Asklepios, Blazquez Bermejo, Z, Caro Codon, J, Lopez Fernandez, T, Valbuena, S, Mori Junco, R, Ponz De Antonio, I, Gemma, D, Rosillo Rodriguez, SO, Moreno Yanguela, M, Lopez-Sendon, JL, MEdicamentos, Grupo de Estudio de CArdiotoxicidad por, Tosello, F, Leone, D, Bruno, G, Ravera, A, Fabbri, A, Sabia, L, Avenatti, E, Milazzo, V, Veglio, F, Milan, A, Cimino, S, Cicogna, F, Cantisani, D, Trivigno, M, Caira, C, Pedrizzetti, G, Tonti, G, Agati, L, Malev, E, Zemtsovsky, E, Omelchenko, M, and Vasina, L

Abstract

Background: The risk stratification of chronic heart failure (CHF) patients can be performed using echocardiographic markers of left ventricle (LV) dysfunction, such as the ejection fraction (EF). LV global longitudinal strain (GLS) showed to be a sensitive measure of myocardium deformation. However, its role as prognostic marker in CHF patients with exclusively systolic dysfunction is still poorly addressed. Objectives: This study sought to evaluate the incremental prognostic role of two-dimensional (2D) LV GLS in CHF outpatients. Methods: Fifty-five patients with CHF and LVEF ≤45% performed a 2D echocardiogram with assessment of conventional parameters and GLS by speckle tracking (STE) imaging averaged from apical 4-chamber, 3-chamber and 2-chamber views. A clinical follow-up of 12 months was performed to assess the occurrence of composite endpoint of overall mortality and nonfatal cardiovascular events. Results: We included 55 patients (mean age 55 ± 12 years, 80% males, 30% with CHF of ischemic etiology, with mean LVEF of 27 ± 9%, median BNP levels 162 [P25-75 56-542] pg/ml). The mean GLS was – 10.35 ± 3.14%. GLS was significantly correlated with NYHA functional class (R=0.41, p=0.002) and BNP levels (r=0.47, p=0.001) and showed a good correlation with LVEF (r=-0.687, p<0.001). The logistic regression analysis showed that GLS (OR 1.548 [95% CI 1.169-2.051]) and LVEF (OR 0.895 [95% CI 0.822-0.976]) were significantly associated with the composite end-point. Other variables that were significantly related with GLS included NYHA functional class (OR 7.333 [95% CI 2.084-25.809]) and BNP levels (OR 1.003 [95% CI 1.001-1.005]). Multivariated regression analysis, including GLS and LVEF, showed an independent association of GLS with adverse outcome (OR 1.460 [95% CI 1.036-2.058]). The area under the receiver operating characteristic (ROC) curve to predict the occurrence of the composite endpoint was 0.798 [0.678-0.919] with an optimal thresholds of -9.5 (80% sensitivity, 70% specificity, p=0.001), while EF had an area under the ROC curve of 0.276 [0.138-0.414]. Conclusions: GLS was strongly associated with severity disease status and predicted the occurrence of adverse outcomes. Quantifying LV GLS in CHF outpatients with systolic dysfunction provides greater accuracy for cardiovascular risk stratification than LVEF.

Published
2014
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31. Poster session Thursday 12 December - PM: 12/12/2013, 14:00-18:00 * Location: Poster area

Author

Garcia Martin, A, Fernandez Golfin, C, Salido Tahoces, L, Fernandez Santos, S, Jimenez Nacher, JJ, Moya Mur, JL, Velasco Valdazo, E, Hernandez Antolin, R, Zamorano Gomez, JL, Veronesi, F, Corsi, C, Caiani, EG, Lamberti, C, Tsang, W, Holmgren, C, Guo, X, Bateman, M, Iaizzo, P, Vannier, M, Lang, RM, Patel, AR, Adamayn, KG, Tumasyan, L R, Chilingaryan, AL, Nasr, G, Eleraki, A, Farouk, N, Axelsson, A, Langhoff, L, Jensen, MK, Vejlstrup, N, Iversen, K, Bundgaard, H, Watanabe, T, Iwai-Takano, M, Attenhofer Jost, C H, Pfyffer, M, Seifert, B, Scharf, C, Candinas, R, Medeiros-Domingo, A, Chin, J-Y, Yoon, HJ, Vollbon, W, Singbal, Y, Rhodes, K, Wahi, S, Katova, T M, Simova, I I, Hristova, K, Kostova, V, Pauncheva, B, Bircan, A, Sade, LE, Eroglu, S, Pirat, B, Okyay, K, Bal, U, Muderrisoglu, H, Heggemann, F, Buggisch, H, Welzel, G, Doesch, C, Hansmann, J, Schoenberg, S, Borggrefe, M, Wenz, F, Papavassiliu, T, Lohr, F, Roussin, I, Drakopoulou, M, Rosen, S, Sharma, R, Prasad, S, Lyon, AR, Carpenter, JP, Senior, R, Breithardt, O-A, Razavi, H, Arya, A, Nabutovsky, Y, Ryu, K, Gaspar, T, Kosiuk, J, Eitel, C, Hindricks, G, Piorkowski, C, Pires, S, Nunes, A, Cortez-Dias, N, Belo, A, Zimbarra Cabrita, I, Sousa, C, Pinto, F, Baron, T, Johansson, K, Flachskampf, FA, Christersson, C, Pires, S, Cortez-Dias, N, Nunes, A, Belo, A, Zimbarra Cabrita, I, Sousa, C, Pinto, F, Santoro, A, Federico Alvino, FA, Giovanni Antonelli, GA, Raffaella De Vito, RDV, Roberta Molle, RM, Sergio Mondillo, SM, Gustafsson, M, Alehagen, U, Johansson, P, Tsukishiro, Y, Onishi, T, Chimura, M, Yamada, S, Taniguchi, Y, Yasaka, Y, Kawai, H, Souza, J R M, Zacharias, L G T, Pithon, K R, Ozahata, T M, Cliquet, A JR, Blotta, M H, Nadruz, W JR, Fabiani, I, Conte, L, Cuono, C, Liga, R, Giannini, C, Barletta, V, Nardi, C, Delle Donne, MG, Palagi, C, Di Bello, V, Glaveckaite, S, Valeviciene, N, Palionis, D, Laucevicius, A, Hristova, K, Bogdanova, V, Ferferieva, V, Shiue, I, Castellon, X, Boles, U, Rakhit, R, Shiu, M F, Gilbert, T, Papachristidis, A, Henein, M Y, Westholm, C, Johnson, J, Jernberg, T, Winter, R, Ghosh Dastidar, A, Augustine, D, Cengarle, M, Mcalindon, E, Bucciarelli-Ducci, C, Nightingale, A, Onishi, T, Watanabe, T, Fujita, M, Mizukami, Y, Sakata, Y, Nakatani, S, Nanto, S, Uematsu, M, Saraste, A, Luotolahti, M, Varis, A, Vasankari, T, Tunturi, S, Taittonen, M, Rautakorpi, P, Airaksinen, J, Ukkonen, H, Knuuti, J, Boshchenko, A, Vrublevsky, A, Karpov, R, Yoshikawa, H, Suzuki, M, Hashimoto, G, Kusunose, Y, Otsuka, T, Nakamura, M, Sugi, K, Rosner, SJ, Orban, M, Lesevic, H, Karl, M, Hadamitzky, M, Sonne, C, Panaro, A, Martinez, F, Huguet, M, Moral, S, Palet, J, Oller, G, Cuso, I, Jornet, A, Rodriguez Palomares, J, Evangelista, A, Stoebe, S, Tarr, A, Pfeiffer, D, Hagendorff, A, Gilmanov, DSH, Baroni, MB, Cerone, EC, Galli, EG, Berti, SB, Glauber, MG, Soesanto, A, Yuniadi, Y, Mansyur, M, Kusmana, D, Venkateshvaran, A, Dash, P K, Sola, S, Govind, S C, Shahgaldi, K, Winter, R, Brodin, L A, Manouras, A, Dokainish, H, Sadreddini, M, Nieuwlaat, R, Lonn, E, Healey, J, Nguyen, V, Cimadevilla, C, Dreyfus, J, Codogno, I, Vahanian, A, Messika-Zeitoun, D, Lim, Y-J, Kawamura, A, Kawano, S, Polte, CL, Gao, S, Lagerstrand, KM, Cederbom, U, Bech-Hanssen, O, Baum, J, Beeres, F, Van Hall, S, Boering, YC, Zeus, T, Kehmeier, ES, Kelm, M, Balzer, JC, Della Mattia, A, Pinamonti, B, Abate, E, Nicolosi, GL, Proclemer, A, Bassetti, M, Luzzati, R, Sinagra, G, Hlubocka, Z, Jiratova, K, Dostalova, G, Hlubocky, J, Dohnalova, A, Linhart, A, Palecek, T, Sonne, C, Lesevic, H, Karl, M, Rosner, S, Hadamitzky, M, Ott, I, Malev, E, Reeva, S, Zemtsovsky, E, Igual Munoz, B, Alonso Fernandez Pau, PAF, Miro Palau Vicente, VMP, Maceira Gonzalez Alicia, AMG, Estornell Erill, JEE, Andres La Huerta, AALH, Donate Bertolin, LDB, Valera Martinez, FVM, Salvador Sanz Antonio, ASS, Montero Argudo Anastasio, AMA, Nemes, A, Kalapos, A, Domsik, P, Chadaide, S, Sepp, R, Forster, T, Onaindia, JJ, Arana, X, Cacicedo, A, Velasco, S, Rodriguez, I, Capelastegui, A, Sadaba, M, Gonzalez, J, Salcedo, A, Laraudogoitia, E, Archontakis, S, Gatzoulis, K, Vlasseros, I, Arsenos, P, Tsiachris, D, Vouliotis, A, Sideris, S, Karistinos, G, Kalikazaros, I, Stefanadis, C, Ancona, R, Comenale Pinto, S, Caso, P, Coppola, MG, Arenga, F, Cavallaro, C, Vecchione, F, Donofrio, A, Calabro, R, Correia, C E, Moreira, D, Cabral, C, Santos, JO, Cardoso, JS, Igual Munoz, B, Maceira Gonzalez, AMG, Estornell Erill Jordi, JEE, Jimenez Carreno, RJC, Arnau Vives, MAV, Monmeneu Menadas, JVMM, Domingo-Valero, DDV, Sanchez Fernandez, ESF, Montero Argudo Anastasio, AMA, Zorio Grima, EZG, Cincin, A, Tigen, K, Karaahmet, T, Dundar, C, Sunbul, M, Guler, A, Bulut, M, Basaran, Y, Mordi, I, Carrick, D, Berry, C, Tzemos, N, Cruz, I, Ferreira, A, Rocha Lopes, L, Joao, I, Almeida, AR, Fazendas, P, Cotrim, C, Pereira, H, Ochoa, J P, Fernandez, A, Filipuzzi, JM, Casabe, JH, Salmo, JF, Vaisbuj, F, Ganum, G, Di Nunzio, HJ, Veron, LF, Guevara, E, Salemi, VMC, Nerbass, FB, Portilho, N, Ferreira Filho, JCA, Pedrosa, RP, Arteaga-Fernandez, E, Mady, C, Drager, LF, Lorenzi-Filho, G, Marques, JS, Almeida, A M G, Menezes, M, Silva, GL, Placido, R, Amaro, C, Brito, D, Diogo, AN, Lourenco, M R, Azevedo, O, Moutinho, J, Nogueira, I, Machado, I, Portugues, J, Quelhas, I, Lourenco, A, Calore, C, Muraru, D, Melacini, P, Badano, LP, Mihaila, S, Puma, L, Peluso, D, Casablanca, S, Ortile, A, Iliceto, S, Kang, M-K, Yu, SH, Park, JJ, Kim, SH, Park, TY, Mun, H-S, C, S, Cho, S-R, Han, SW, Lee, N, Khalifa, E A, Hamodraka, E, Kallistratos, M, Zacharopoulou, I, Kouremenos, N, Mavropoulos, D, Tsoukas, A, Kontogiannis, N, Papanikolaou, N, Tsoukanas, K, Manolis, A, Villagraz Tecedor, L, Jimenez Lopez Guarch, C, Alonso Chaterina, S, Blazquez Arrollo, L, Lopez Melgar, B, Veitia Sarmiento, AL, Mayordomo Gomez, S, Escribano Subias, MP, Lichodziejewska, B, Kurnicka, K, Goliszek, S, Dzikowska Diduch, O, Kostrubiec, M, Krupa, M, Grudzka, K, Ciurzynski, M, Palczewski, P, Pruszczyk, P, Sakata, K, Ishiguro, M, Kimura, G, Uesugo, Y, Takemoto, K, Minamishima, T, Futuya, M, Matsue, S, Satoh, T, Yoshino, H, Signorello, MC, Gianturco, L, Colombo, C, Stella, D, Atzeni, F, Boccassini, L, Sarzi-Puttini, PC, Turiel, M, Kinova, E, Deliiska, B, Krivoshiev, S, Goudev, A, De Stefano, F, Santoro, C, Buonauro, A, Schiano-Lomoriello, V, Muscariello, R, De Palma, D, Galderisi, M, Ranganadha Babu, B, Chidambaram, SUNDAR, Sangareddi, V, Dhandapani, VE, Ravi, MS, Meenakshi, K, Muthukumar, D, Swaminathan, N, Ravishankar, G, Bruno, R M, Giardini, G, Catizzo, B, Brustia, R, Malacrida, S, Armenia, S, Cauchy, E, Pratali, L, Resamont2, Cesana, F, Alloni, M, Vallerio, P, De Chiara, B, Musca, F, Belli, O, Ricotta, R, Siena, S, Moreo, A, Giannattasio, C, Magnino, C, Omede, P, Avenatti, E, Presutti, D, Sabia, L, Moretti, C, Bucca, C, Gaita, F, Veglio, F, Milan, A, Eichhorn, JG, Springer, W, Helling, A, Alarajab, A, Loukanov, T, Ikeda, M, Kijima, Y, Akagi, T, Toh, N, Oe, H, Nakagawa, K, Tanabe, Y, Watanabe, N, Ito, H, Hascoet, S, Hadeed, K, Marchal, P, Bennadji, A, Peyre, M, Dulac, Y, Heitz, F, Alacoque, X, Chausseray, G, Acar, P, Kong, WILL, Ling, LH, Yip, JAMES, Poh, KK, Vassiliou, V, Rekhraj, S, Hoole, SP, Watkinson, O, Kydd, A, Boyd, J, Mcnab, D, Densem, C, Shapiro, LM, Rana, BS, Potpara, TS, Djikic, D, Polovina, M, Marcetic, Z, Peric, V, Lip, GYH, Gaudron, P, Niemann, M, Herrmann, S, Hu, K, Strotmann, J, Beer, M, Bijnens, B, Liu, D, Ertl, G, Weidemann, F, Peric, V, Jovanovic, A, Djikic, D, Otasevic, P, Kochanowski, J, Piatkowski, R, Scislo, P, Grabowski, M, Marchel, M, Opolski, G, Bandera, F, Guazzi, M, Arena, R, Corra, U, Ghio, S, Forfia, P, Rossi, A, Dini, F, Cahalin, LP, Temporelli, L, Rallidis, L, Tsangaris, I, Makavos, G, Anthi, A, Pappas, A, Orfanos, S, Lekakis, J, Anastasiou-Nana, M, Kuznetsov, V A, Krinochkin, D V, Yaroslavskaya, E I, Zaharova, E H, Pushkarev, G S, Mizia-Stec, K, Wita, K, Mizia, M, Loboz-Grudzien, K, Szwed, H, Kowalik, I, Kukulski, T, Gosciniak, P, Kasprzak, J, Plonska-Gosciniak, E, Cimino, S, Pedrizzetti, G, Tonti, G, Cicogna, F, Petronilli, V, De Luca, L, Iacoboni, C, Agati, L, Hoffmann, R, Barletta, G, Von Bardeleben, S, Kasprzak, J, Greis, C, Vanoverschelde, J, Becher, H, Galrinho, A, Moura Branco, L, Fiarresga, A, Cacela, D, Ramos, R, Cruz Ferreira, R, Van Den Oord, SCH, Akkus, Z, Bosch, JG, Renaud, G, Sijbrands, EJG, Verhagen, HJM, Van Der Lugt, A, Van Der Steen, AFW, Schinkel, AFL, Mordi, I, Tzemos, N, Stanton, T, Delgado, D, Yu, E, Drakopoulou, M, Gonzalez-Gonzalez, AM, Karonis, T, Roussin, I, Babu-Narayan, S, Swan, L, Senior, R, Li, W, Parisi, V, Pagano, G, Pellegrino, T, Femminella, GD, De Lucia, C, Formisano, R, Cuocolo, A, Perrone Filardi, P, Leosco, D, Rengo, G, Unlu, S, Farsalinos, K, Amelot, K, Daraban, A, Ciarka, A, Delcroix, M, Voigt, JU, Miskovic, A, Poerner, TD, Goebel, B, Stiller, CH, Moritz, A, Sakata, K, Uesugo, Y, Kimura, G, Ishiguro, M, Takemoto, K, Minamishima, T, Futuya, M, Satoh, T, Yoshino, H, Miyoshi, T, Tanaka, H, Kaneko, A, Matsumoto, K, Imanishi, J, Motoji, Y, Mochizuki, Y, Minami, H, Kawai, H, Hirata, K, Wutthimanop, A, See, O, Vathesathokit, P, Yamwong, S, Sritara, P, Rosner, A, Kildal, AB, Stenberg, TA, Myrmel, T, How, OJ, Capriolo, M, Frea, S, Giustetto, C, Scrocco, C, Benedetto, S, Grosso Marra, W, Morello, M, Gaita, F, Garcia-Gonzalez, P, Cozar-Santiago, P, Chacon-Hernandez, N, Ferrando-Beltran, M, Fabregat-Andres, O, De La Espriella-Juan, R, Fontane-Martinez, C, Jurado-Sanchez, R, Morell-Cabedo, S, Ridocci-Soriano, F, Mihaila, S, Piasentini, E, Muraru, D, Peluso, D, Casablanca, S, Puma, L, Naso, P, Iliceto, S, Vinereanu, D, Badano, LP, Tarzia, P, Villano, A, Figliozzi, S, Russo, G, Parrinello, R, Lamendola, P, Sestito, A, Lanza, GA, Crea, F, Sulemane, S, Panoulas, VF, Bratsas, A, Frankel, AH, Nihoyannopoulos, P, Dores, H, Andrade, MJ, Almeida, MS, Goncalves, PA, Branco, P, Gaspar, A, Gomes, A, Horta, E, Carvalho, MS, Mendes, M, Yue, WS, Li, XY, Chen, Y, Luo, Y, Gu, P, Yiu, KH, Siu, CW, Tse, HF, Cho, EJ, Lee, SH, Hwang, BH, Kim, DB, Jang, SW, Jeon, HK, Youn, HJ, and Kim, JH

Abstract

Background: Progress in the technique of TAVR requires good knowledge of the aortic root. With this aim new specialized software appears, with the ability of automated quantitative modeling of the AV and root from 3D TEE.The purpose of this study was to validate this model with the measurements made manually. Methods: Eight patients undergoing TAVR in our center where included. The diameters of the aortic annulus, sinotubular union (STU) and sinus of valsalva (SV) were measured by 2D TEE; diameters and areas of aortic annulus, STU and SV as well as anatomic aortic valve area were measured by 3D TEE. Afterwards, the images were analyzed using the new software (Figure 1). Results. We showed good correlation with aortic annulus diameter measured by 2D TEE (r:,832 p:,01) and excellent correlation with one of the aortic annulus diameter measured by 3D TEE (r:,941 p:,00). The same happened with the area (r:,720 p:,04). Regarding the measurements at SV level, the correlations between the diameters by 2D TEE and 3D TEE with the measurements obtained with the new model were the following (r:,771;p:,025) and (r:,797;p:,018). The correlation of the area was also good (r:,812 p:,014).An excellent correlation was found between the measurements at UST level. UST diameter by 2D TEE (r:,818;P:,013), by ETE3D (r:,800;p:,017) and area (r:,844;p:,008).Finally, the anatomic aortic valve area measured by the new model showed significant correlation with the 3D TTE (r:,830 p:,011). Conclusions. There is a proper correlation between manual and automated measurements analyzed by the new model. The feasibility of determine the TAVR results with geometric models based on image, prior to procedure, is one of the possibilities of this new software. Prospective studies are necessary to define its applicability. Figure 1

Published
2013
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32. Left atrial volume indexed for height2 is a new sensitive marker for subclinical cardiac organ damage in female hypertensive patients

Author

Eleonora Avenatti, Eugenia Ianniello, Anna Paini, Maria Lorenza Muiesan, Lorenzo Airale, Raffaele Izzo, Stefano Bacchelli, Cristina Giannattasio, Giacomo Pucci, Paola Sormani, Daniela Degli Esposti, Alberto Milan, Gaetano Vaudo, Nicola De Luca, Massimo Salvetti, Alessio Arrivi, Costantino Mancusi, Antonella Moreo, Airale, L., Paini, A., Ianniello, E., Mancusi, C., Moreo, A., Vaudo, G., Avenatti, E., Salvetti, M., Bacchelli, S., Izzo, R., Sormani, P., Arrivi, A., Muiesan, M. L., Esposti, D. D., Giannattasio, C., Pucci, G., De Luca, N., Milan, A., Airale, L, Paini, A, Ianniello, E, Mancusi, C, Moreo, A, Vaudo, G, Avenatti, E, Salvetti, M, Bacchelli, S, Izzo, R, Sormani, P, Arrivi, A, Muiesan, M, Esposti, D, Giannattasio, C, Pucci, G, De Luca, N, and Milan, A

Subjects
Arterial hypertension, medicine.medical_specialty, Physiology, Left atrial enlargement, Transthoracic echocardiography, Population, 030204 cardiovascular system & hematology, Left ventricular hypertrophy, 03 medical and health sciences, 0302 clinical medicine, Left atrial, Internal medicine, Internal Medicine, medicine, Prevalence, 030212 general & internal medicine, education, Subclinical infection, Body surface area, education.field_of_study, business.industry, Female sex, medicine.disease, Organ damage, Left atrium, Cardiology, Cardiology and Cardiovascular Medicine, business
Abstract

Left atrial enlargement (LAe) is a subclinical marker of hypertensive-mediated organ damage, which is important to identify in cardiovascular risk stratification. Recently, LA indexing for height was suggested as a more accurate marker of defining LAe. Our aim was to test the difference in LAe prevalence using body surface area (BSA) and height2 definitions in an essential hypertensive population. A total of 441 essential hypertensive patients underwent complete clinical and echocardiographic evaluation. Left atrial volume (LAV), left ventricular morphology, and systolic-diastolic function were evaluated. LAe was twice as prevalent when defined using height2 (LAeh2) indexation rather than BSA (LAeBSA) (51% vs. 23%, p < 0.001). LAeh2, but not LAeBSA, was more prevalent in females (p < 0.001). Males and females also differed in left ventricular hypertrophy (p = 0.046) and left ventricular diastolic dysfunction (LVDD) indexes (septal Em/Etdi: p = 0.009; lateral Em/Etdi: p = 0.003; mean Em/Etdi: p < 0.002). All patients presenting LAeBSA also met the criteria for LAeh2. According to the presence/absence of LAe, we created three groups (Norm = BSA−/h2-; DilH = BSA−/h2+; DilHB = BSA+/h2+). The female sex prevalence in the DilH group was higher than that in the other two groups (Norm: p < 0.001; DilHB: p = 0.036). LVH and mean and septal Em/Etdi increased from the Norm to the DilH group and from the DilH to the DilHB group (p < 0.05 for all comparisons). These results show that LAeh2 identified twice as many patients as comparing LAe to LAeBSA, but that both LAeh2 and LAeBSA definitions were associated with LVH and LVDD. In female patients, the LAeh2 definition and its sex-specific threshold seem to be more sensitive than LAeBSA in identifying chamber enlargement.

Published
2021

34. Obesity as a Disease: A Primer on Clinical and Physiological Insights.

Author

Shah A, Davarci O, Chaftari P, and Avenatti E

Subjects
Humans, Risk Factors, Prognosis, Risk Assessment, Prevalence, Female, Male, Obesity epidemiology, Obesity physiopathology
Abstract

Obesity is now recognized as a multifaceted chronic disease that is intricately linked to metabolic, biochemical, and psychosocial dysfunction. In this article, we review the epidemiology of obesity, current understanding of its physiopathology, and the recommended staging system used to approach it as a chronic disease, and we include an overview of its health implications., Competing Interests: The authors have no competing interests to declare., (Copyright: © 2025 The Author(s).)

Published
2025
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35. Burden of Atherosclerotic Disease Risk Factors in Patients With and Without Rheumatologic Disease: A Retrospective Cohort Study.

Author

DiGregorio H, Avenatti E, Gullapelli R, Williams K, El Hajj E, Foster C, Das S, Shahid I, Shah A, Nicolas J, Bose B, Hagan K, Lahan S, Nwana N, Butt S, Javed Z, Karam LR, Monga K, Guevara M, Weber B, Patel K, Al-Kindi SG, and Nasir K

Subjects
Humans, Retrospective Studies, Female, Male, Middle Aged, Risk Factors, Aged, Atherosclerosis epidemiology, Rheumatic Diseases epidemiology, Rheumatic Diseases complications
Abstract

Competing Interests: Declaration of competing interest The authors have no competing interests to declare.

Published
2024
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36. Gender disparities in utilization of statins for low density lipoprotein management across the spectrum of atherosclerotic cardiovascular disease: Insights from the houston methodist cardiovascular disease learning health system registry.

Author

Shahid I, Satish P, Gullapelli R, Nicholas JC, Javed Z, Avenatti E, Bose B, Mahajan S, Roy T, Sharma G, Rodriguez F, Andrieni J, Jones SL, Al-Kindi S, Cainzos-Achirica M, and Nasir K

Abstract

Introduction: Lower statin utilization is reported among women compared to men, however large-scale studies evaluating gender disparities in LDL-C management in individuals with ASCVD and its subtypes remain limited, particularly across age and racial/ethnic subgroups. In this study, we address this knowledge gap using data from a large US healthcare system., Methods: All adult patients with established ASCVD in the Houston Methodist Learning Health System Registry during 2016-2022 were included. Statin use and dose were extracted from the database. The association between gender and statin utilization was evaluated using multivariate logistic regression analyses in patients with ASCVD overall, across ASCVD subtypes, and by age, racial/ethnic subgroups, and socioeconomic risk factors., Results: A total of 97,819 patients with prevalent ASCVD were included. Women with ASCVD had lower utilization of any statin (64.3% vs 72.6 %; p < 0.001) and high-intensity statin (29.8% vs 42.5 % p < 0.001) compared with men. In fully adjusted models, women had 40 % lower odds of any (adjusted odds ratio [aOR]:0.58, 95 % CI 0.57-0.60) and high-intensity statin use (aOR:0.59, 0.57-0.61) relative to men. Women were also less likely to have guideline-recommended LDL-C < 70 mg/dL (30.2% vs 42.7 %; p < 0.01). These differences persisted across age, racial/ethnic and socioeconomic subgroups., Conclusion: Significant gender disparities exist in contemporary lipid management among patients with ASCVD, with women being less likely to receive any and high-intensity statin and achieving guideline defined LDL-C goal compared with men across age and racial/ethnic subgroups. These disparities underscore the need to further understand potential socioeconomic drivers of the observed lower statin uptake in women., Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: FR reports consulting fees from Novartis, NovoNordisk (CEC), Esperion, and HealthPals. KN is on the advisory board of Amgen, Novartis, Novo Nordisk, and his research is partly supported by the Jerold B. Katz Academy of Translational Research. All other authors report no disclosures relevant to the work of this manuscript., (© 2024 The Authors. Published by Elsevier B.V.)

Published
2024
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37. Repeat left ventricular-assisted device exchange and upgrade from second- to third-generation devices in a high-volume single center.

Author

Kassi M, Avenatti E, Hoang KD, Zook S, Yousafzai R, Guha A, Bhimaraj A, Chou LP, and Suarez EE

Subjects
Humans, Retrospective Studies, Hospitals, Heart Failure surgery, Heart Transplantation, Heart-Assist Devices adverse effects
Abstract

Background: Pump exchange is an established strategy to treat LVAD-related complications such as thrombosis, infection, and driveline failure. Pump upgrades with an exchange to newer generation devices are being performed to the advantage of the patient on long-term support. The safety and efficacy of a repeat LVAD exchange with a concomitant upgrade to a third-generation pump have not been reported., Methods: We performed a retrospective analysis of all consecutive patients who underwent a repeat LVAD device exchange and upgrade to HeartMate III (HMIII) at Houston Methodist Hospital between December 2018 and December 2020., Results: Five patients underwent exchange and upgrade to HMIII within the specified timeframe. Four patients had already had two prior exchanges (all HMII to HMII), and one patient had one prior exchange (HVAD to HVAD). In all cases, implantation was performed as destination therapy. The surgical exchange was performed via redo median sternotomy on full cardiopulmonary bypass. No unplanned redo surgery of the device component was required. In-hospital mortality was 20% in this very high-risk population. At 1-, 3-, and 6-month follow-up, all discharged patients were on HMIII support, with no major LVAD-related adverse events reported., Conclusion: We report the feasibility and safety of a repeat pump exchange with an upgrade to HMIII in a high-volume center. The decision for medical therapy versus surgical exchange has to be tailored to individual cases based on risk factors and clinical stability but in expert hands, even a re-redo surgical approach grants options for good medium-term outcomes., (© 2024 International Center for Artificial Organ and Transplantation (ICAOT) and Wiley Periodicals LLC.)

Published
2024
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38. Understanding the spectrum of cardiovascular risk in women - A primer for prevention.

Author

Satish P, Avenatti E, Patel J, and Agarwala A

Subjects
Humans, Female, Risk Assessment, Sex Factors, Health Status Disparities, Prognosis, Pregnancy, Healthcare Disparities, Risk Factors, Cardiovascular Diseases prevention & control, Cardiovascular Diseases epidemiology, Heart Disease Risk Factors, Women's Health
Abstract

Cardiovascular disease (CVD) is the leading cause of death in women worldwide and the lifetime risk of CVD in women is similar to men. However, the pathophysiology of CVD varies between women and men necessitating a sex-specific understanding of cardiovascular (CV) risk. A belief that women have a lower CVD risk than men, and an underrepresentation in clinical research for many years has led to a paucity of evidence in the prevention and management of CVD in women. Many recent efforts have tried to bridge the gap. As a result, we now know that traditional risk factors impact CVD risk differently in women when compared with men. There are also numerous sex-specific and pregnancy related risk factors that modify the risk and can predict the future development of CVD in women. This is important as risk calculators, in general, tend to misclassify risk in young women with nontraditional CVD risk factors. To address this, guidelines have introduced the concept of risk enhancers that can suggest a higher risk. The use of coronary artery calcium score can further accurately delineate risk in these women, leading to an appropriate matching of therapy to underlying risk. This review discusses implementation strategies that are essential to mitigate disparities in CVD outcomes and optimizing CVD risk in women., Competing Interests: Declaration of competing interest None., (Copyright © 2023. Published by Elsevier Inc.)

Published
2024
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39. Primary Prevention of Cardiovascular Disease in Women.

Author

Shahid I, Avenatti E, Titus A, Al-Kindi S, and Nasir K

Subjects
Pregnancy, Female, Humans, Menopause, Risk Factors, Primary Prevention, Cardiovascular Diseases diagnosis, Cardiovascular Diseases epidemiology, Cardiovascular Diseases prevention & control, Hypertension
Abstract

Cardiovascular disease (CVD) remains a leading cause of mortality in women, necessitating innovative primary prevention strategies. Contemporary guidelines on primary prevention of CVD highlight the increasing prevalence of CVD risk factors and emphasize the significance of female-specific risk enhancers that substantially augment the future risk of CVD. These risk factors occur throughout a woman's life cycle, such as hormonal contraception, hypertensive disorders of pregnancy, and menopause, all of which confer an added layer of risk in women beyond the conventional risk factors. Despite this, current methods may not fully capture the nuanced vulnerabilities in women that increase their risk of CVD. In this review, we highlight gender-specific risk enhancers and subsequent prevention as well as strategies to improve primary prevention of CVD in women., Competing Interests: Dr. Nasir serves on the advisory boards of Amgen, Novartis, and Novo Nordisk, and his research is partly supported by the Jerold B. Katz Academy of Translational Research. The other authors have no competing interests to declare., (Copyright: © 2024 The Author(s).)

Published
2024
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40. Patient-specific, echocardiography compatible flow loop model of aortic valve regurgitation in the setting of a mechanical assist device.

Author

Kassi M, Filippini S, Avenatti E, Xu S, El-Tallawi KC, Angulo CI, Vukicevic M, and Little SH

Abstract

Background: Aortic regurgitation (AR) occurs commonly in patients with continuous-flow left ventricular assist devices (LVAD). No gold standard is available to assess AR severity in this setting. Aim of this study was to create a patient-specific model of AR-LVAD with tailored AR flow assessed by Doppler echocardiography., Methods: An echo-compatible flow loop incorporating a 3D printed left heart of a Heart Mate II (HMII) recipient with known significant AR was created. Forward flow and LVAD flow at different LVAD speed were directly measured and AR regurgitant volume (RegVol) obtained by subtraction. Doppler parameters of AR were simultaneously measured at each LVAD speed., Results: We reproduced hemodynamics in a LVAD recipient with AR. AR in the model replicated accurately the AR in the index patient by comparable Color Doppler assessment. Forward flow increased from 4.09 to 5.61 L/min with LVAD speed increasing from 8,800 to 11,000 RPM while RegVol increased by 0.5 L/min (2.01 to 2.5 L/min)., Conclusions: Our circulatory flow loop was able to accurately replicate AR severity and flow hemodynamics in an LVAD recipient. This model can be reliably used to study echo parameters and aid clinical management of patients with LVAD., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Kassi, Filippini, Avenatti, Xu, El-Tallawi, Angulo, Vukicevic and Little.)

Published
2023
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41. Pharmacotherapy for Essential Hypertension: A Brief Review.

Author

Heidari B, Avenatti E, and Nasir K

Subjects
Humans, Calcium Channel Blockers therapeutic use, Antihypertensive Agents adverse effects, Essential Hypertension drug therapy, Diuretics therapeutic use, Adrenergic beta-Antagonists therapeutic use, Angiotensin-Converting Enzyme Inhibitors therapeutic use, Hypertension diagnosis, Hypertension drug therapy, Hypertension epidemiology
Abstract

Hypertension is one of the leading causes of disability-adjusted life years and mortality, with approximately 15% prevalence worldwide. Most patients with hypertension from low- to high-income countries do not receive treatment. Among those who receive treatment, the majority remain undertreated and do not achieve their blood pressure goals. Therefore, new hypertension guidelines introduce more conscientious treatment strategies to maximize the probability of achieving the new strict blood pressure goals compared with the previous guidelines. Who should receive treatment for hypertension? Which antihypertensive medications have the strongest supporting data? Are generic and more affordable medications as effective as expensive brand medications? What are the different treatment strategies to maximize success in controlling blood pressure? Here, we briefly review pharmacotherapy for hypertension and provide answers to these questions as well as some other common questions regarding treatment of hypertension., Competing Interests: The authors have no competing interests to declare., (Copyright: © 2022 The Author(s).)

Published
2022
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42. Accuracy of a new instrument for noninvasive evaluation of pulse wave velocity: the Arterial sTiffness faitHful tOol aSsessment project.

Author

Leone D, Buraioli I, Mingrone G, Lena D, Sanginario A, Vallelonga F, Tosello F, Avenatti E, Cesareo M, Astarita A, Airale L, Sabia L, Veglio F, Demarchi D, and Milan A

Subjects
Carotid Arteries, Carotid-Femoral Pulse Wave Velocity, Humans, Reproducibility of Results, Risk Factors, Pulse Wave Analysis, Vascular Stiffness
Abstract

Background: Large artery stiffness, assessed by carotid--femoral pulse wave velocity (cfPWV), is a major risk factor for cardiovascular events, commonly used for risk stratification. Currently, the reference device for noninvasive cfPWV is SphygmoCor but its cost and technically challenging use limit its diffusion in clinical practice., Aim: To validate a new device for noninvasive assessment of cfPWV, ATHOS (Arterial sTiffness faitHful tOol aSsessment), designed in collaboration with the Politecnico di Torino, against the reference noninvasive method represented by SphygmoCor., Methods: Ninety healthy volunteers were recruited. In each volunteer, we assessed cfPWV, using SphygmoCor (PWVSphygmoCor) and ATHOS (PWVATHOS) devices in an alternate fashion, following the ARTERY Society guidelines. The accuracy was assessed by Bland--Altman plot, and reproducibility was assessed by interoperator correlation coefficient (ICC)., Results: Mean PWVATHOS and mean PWVSphygmoCor were 7.88 ± 1.96 and 7.72 ± 1.95 m/s, respectively. Mean difference between devices was 0.15 ± 0.56 m/s, with a high correlation between measurements (r = 0.959, P < 0.001). Considering only PWV values at least 8 m/s (n = 30), mean difference was 0.1 ± 0.63 m/s. The ICC was 97.7% with ATHOS., Conclusion: ATHOS showed an excellent level of agreement with SphygmoCor, even at high PWV values, with a good reproducibility. Its simplicity of use could help increase clinical application of PWV assessment, improving patients' cardiovascular risk stratification., (Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)

Published
2021
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43. A Checklist Approach for Enhanced Outpatient Guideline-Directed Management in the Secondary Prevention of Atherosclerotic Cardiovascular Disease.

Author

Taha MB, Avenatti E, Li DS, Ohonba T, Cainzos-Achirica M, Patel KV, and Nasir K

Subjects
Checklist, Humans, Outpatients, Secondary Prevention, Atherosclerosis diagnosis, Atherosclerosis prevention & control, Cardiovascular Diseases diagnosis, Cardiovascular Diseases epidemiology, Cardiovascular Diseases prevention & control
Abstract

Compelling results from clinical trials supporting intensive risk-reduction therapies to reduce associated morbidity and mortality in patients with established atherosclerotic cardiovascular disease (ASCVD) provided the impetus for medical societies to integrate these evidence-based results into clinical practice guidelines. Current evidence, however, points toward gaps in the management of patients with established ASCVD. Some of these gaps are related to barriers to guideline implementation, and strategies are needed to overcome these barriers. In this review, we propose a framework incorporating comprehensive tools for enhanced guideline-directed management in secondary prevention of ASCVD. This aid includes a 13-point checklist with supporting educational and system-based tools for effective evidence-based pharmacological and nonpharmacological care. This proposed tool targets primary care providers and cardiologists in the outpatient setting who provide direct medical care for patients with established ASCVD., Competing Interests: Dr. Nasir is a formal advisor to Amgen, Novartis, Esperion, and Novo Nordisk, and is on the speaker’s bureau for Amgen., (Copyright: © 2021 The Author(s).)

Published
2021
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44. A Novel Approach to Left Ventricular Filling Pressure Assessment: The Role of Hemodynamic Forces Analysis.

Author

Airale L, Vallelonga F, Forni T, Leone D, Magnino C, Avenatti E, Iannaccone A, Astarita A, Mingrone G, Cesareo M, Giordana C, Omedè P, Moretti C, Veglio F, Pedrizzetti G, and Milan A

Abstract

Background: Diastolic function in patients with heart failure is usually impaired, resulting in increased left ventricular (LV) filling pressures, whose gold standard assessment is right heart catheterization (RHC). Hemodynamic force (HDF) analysis is a novel echocardiographic tool, providing an original approach to cardiac function assessment through the speckle-tracking technology. The aim of our study was to evaluate the use of HDFs, both alone and included in a new predictive model, as a potential novel diagnostic tool of the diastolic function. Methods: HDF analysis was retrospectively performed in 67 patients enrolled in the "Right1 study." All patients underwent RHC and echocardiography up to 2 h apart. Increased LV filling pressure (ILFP) was defined as pulmonary capillary wedge pressure (PCWP) ≥ 15 mmHg. Results: Out of 67 patients, 33 (49.2%) showed ILFP at RHC. Diastolic longitudinal force (DLF), the mean amplitude of longitudinal forces during diastole, was associated with the presence of ILFP (OR = 0.84 [0.70; 0.99], p = 0.046). The PCWP prediction score we built including DLF, ejection fraction, left atrial enlargement, and e' septal showed an AUC of 0.83 [0.76-0.89], with an optimal internal validation. When applied to our population, the score showed a sensitivity of 72.7% and a specificity of 85.3%, which became 66.7 and 94.4%, respectively, when applied to patients classified with "indeterminate diastolic function" according to the current recommendations. Conclusion: HDF analysis could be an additional useful tool in diastolic function assessment. A scoring system including HDFs might improve echocardiographic accuracy in estimating LV filling pressures. Further carefully designed studies could be useful to clarify the additional value of this new technology., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Airale, Vallelonga, Forni, Leone, Magnino, Avenatti, Iannaccone, Astarita, Mingrone, Cesareo, Giordana, Omedè, Moretti, Veglio, Pedrizzetti and Milan.)

Published
2021
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45. Local transversal aortic strain is impaired in ascending aorta dilatation.

Author

Cesareo M, Sabia L, Leone D, Avenatti E, Astarita A, Mingrone G, Airale L, Veglio F, Vallelonga F, and Milan A

Subjects
Aorta diagnostic imaging, Dilatation, Dilatation, Pathologic diagnostic imaging, Humans, Pulse Wave Analysis, Aortic Diseases diagnostic imaging, Vascular Stiffness
Abstract

Background: Ascending aorta dilatation is found in 13% of hypertensive patients. Little is known about elastic properties of ascending aorta in such patients. Echo-based transverse aortic strain analysis can describe mechanical properties of ascending aorta but has never been applied to patients with ascending aorta dilatation., Aim: To assess mechanical properties of ascending aorta by transverse aortic strain analysis (as β2-stiffness index) in hypertensive patients with ascending aorta dilatation and association between mechanical properties of ascending aorta and cardiovascular damage., Methods: A total of 100 hypertensive outpatients underwent transthoracic echocardiography and assessment of pulse wave velocity (PWV). Strain analysis of ascending aorta was performed with echocardiographic speckle-tracking software. Patients were divided in three groups based on ascending aorta diameter: less than 40, 40-45, and at least 45 mm., Results: Beta-SI increased exponentially with ascending aorta dimensions (P < 0.001). Patients with ascending aorta dilatation had Beta-SI significantly higher than those with normal ascending aorta diameter. A greater proportion of patient with impaired (i.e., elevated) Beta-SI was present in groups with larger ascending aorta (18.2 vs. 48.4 vs. 80%, respectively, P < 0.05). On multivariate logistic regression only impaired Beta-SI predicted ascending aorta dilatation (P < 0.001). Beta-SI was related to cardiovascular damage in terms of left ventricular (LV) mass (LV mass indexed to BSA, P = 0.030) and PWV (P = 0.028). Patients with high Beta-SI had greater LV mass indexed to BSA (117 ± 47 vs. 94 ± 24 g/m2; P = 0.010) and PWV (10.20 ± 2.99 vs. 8.63 ± 1.88 m/s; P = 0.013)., Conclusion: Ascending aorta dilatation is associated with increased local aortic stiffness in hypertensive patients. Strain analysis adds functional information to the mere morphological evaluation of aortic diameter and could be a useful tool to better define cardiovascular risk in this population., (Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)

Published
2021
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46. Left atrial volume indexed for height 2 is a new sensitive marker for subclinical cardiac organ damage in female hypertensive patients.

Author

Airale L, Paini A, Ianniello E, Mancusi C, Moreo A, Vaudo G, Avenatti E, Salvetti M, Bacchelli S, Izzo R, Sormani P, Arrivi A, Muiesan ML, Esposti DD, Giannattasio C, Pucci G, De Luca N, and Milan A

Subjects
Biomarkers, Echocardiography, Female, Heart Ventricles diagnostic imaging, Humans, Hypertrophy, Left Ventricular diagnostic imaging, Male, Body Height, Heart Atria diagnostic imaging, Heart Atria pathology, Hypertension diagnostic imaging, Ventricular Dysfunction, Left diagnostic imaging
Abstract

Left atrial enlargement (LAe) is a subclinical marker of hypertensive-mediated organ damage, which is important to identify in cardiovascular risk stratification. Recently, LA indexing for height was suggested as a more accurate marker of defining LAe. Our aim was to test the difference in LAe prevalence using body surface area (BSA) and height 2 definitions in an essential hypertensive population. A total of 441 essential hypertensive patients underwent complete clinical and echocardiographic evaluation. Left atrial volume (LAV), left ventricular morphology, and systolic-diastolic function were evaluated. LAe was twice as prevalent when defined using height 2 (LAe h2 ) indexation rather than BSA (LAe BSA ) (51% vs. 23%, p < 0.001). LAe h2 , but not LAe BSA , was more prevalent in females (p < 0.001). Males and females also differed in left ventricular hypertrophy (p = 0.046) and left ventricular diastolic dysfunction (LVDD) indexes (septal Em/Etdi: p = 0.009; lateral Em/Etdi: p = 0.003; mean Em/Etdi: p < 0.002). All patients presenting LAe BSA also met the criteria for LAe h2 . According to the presence/absence of LAe, we created three groups (Norm = BSA-/h 2 -; DilH = BSA-/h 2 +; DilHB = BSA+/h 2 +). The female sex prevalence in the DilH group was higher than that in the other two groups (Norm: p < 0.001; DilHB: p = 0.036). LVH and mean and septal Em/Etdi increased from the Norm to the DilH group and from the DilH to the DilHB group (p < 0.05 for all comparisons). These results show that LAe h2 identified twice as many patients as comparing LAe to LAe BSA , but that both LAe h2 and LAe BSA definitions were associated with LVH and LVDD. In female patients, the LAe h2 definition and its sex-specific threshold seem to be more sensitive than LAe BSA in identifying chamber enlargement.

Published
2021
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47. Prognostic role of the ascending aorta dilatation in patients with arterial hypertension.

Author

Leone D, Airale L, Bernardi S, Mingrone G, Astarita A, Cesareo M, Sabia L, Avenatti E, Tosello F, Bruno G, Catarinella C, Venturelli V, Giordana C, Veglio F, Vallelonga F, and Milan A

Subjects
Aorta diagnostic imaging, Dilatation, Dilatation, Pathologic diagnostic imaging, Humans, Prognosis, Hypertension complications, Pulse Wave Analysis
Abstract

Background: Ascending aorta (ASC) dilatation (AAD) is a common finding in arterial hypertension, affecting about 15% of hypertensive patients. AAD is associated with an increase in cardiac and vascular hypertension-related organ damage, but its prognostic role is unknown. The aim of the study was to evaluate the prognostic value of AAD as predictor of cardiovascular events in essential hypertensive patients., Methods: Recruited patients underwent two-dimensional transthoracic echocardiography from 2007 to 2013 and followed-up for cardiovascular events until November 2018 by phone call and hospital information system check. ASC diameter and AAD were defined using both absolute and scaled definitions. Four hundred and twenty-three hypertensive patients were included in our study., Results: During a median follow-up of 7.4 years (interquartile range 5.6-9.1 years), 52 events were observed. After adjusting for age, sex and BSA, both ASC diameter and AAD definition, according to ARGO-SIIA project, resulted associated with a greater risk of cardiovascular event (both P < 0.010), even after adjusting for major confounders (both P < 0.010). Moreover, we observed that the assessment of ASC improves risk stratification compared with pulse wave velocity alone, and that in absence of AAD, sinus of valsalva dilatation lost any prognostic value (P = 0.262)., Conclusions: ASC diameter and AAD are both associated with a greater risk of cardiovascular events. ASC should be assessed to optimize risk stratification in hypertensive patients and its dilatation may be considered as a surrogate for vascular organ damage., (Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)

Published
2021
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48. Central pulse pressure is inversely associated with proximal aortic remodelling.

Author

Tosello F, Guala A, D'ascenzo F, Bollati M, Leone D, Sabia L, Bruno G, Mingrone G, Astarita A, Vallelonga F, Avenatti E, Moretti C, Veglio F, Ridolfi L, and Milan A

Subjects
Arterial Pressure, Blood Pressure, Dilatation, Pathologic, Humans, Aorta, Hypertension
Abstract

Objectives: Hypertension leads to aortic stiffening and dilatation but unexpected data from the Framingham Heart Study showed an inverse relationship between brachial pulse pressure and aortic diameter. Aortic dilatation would not only lead to lower pulse pressure but also to a worse prognosis (cardiac events, heart failure). Invasive pressure may be more informative but data are lacking., Aim: This study evaluated the relationship between invasively measured central blood pressure and proximal aortic diameter., Methods: In 71 consecutive patients referred to invasive haemodynamic study, proximal aortic remodelling was evaluated in terms of Z-score, comparing diameters measured at the sinus of Valsalva to the diameter expected according to patients' age, sex and body height. Pressures were recorded directly in the proximal aorta by means of a catheter before coronary assessment., Results: The mean invasive aortic SBPs and DBPs were 146 ± 23 and 78 ± 13 mmHg, respectively, giving a central pulse pressure (cPP inv) of 68 ± 21 mmHg. Proximal aortic diameter was 34.9 ± 19.4 mm, whereas Z-score was -0.3 ± 1.7. Patients with higher cPPinv showed a significantly lower Z-score (-0.789 vs. 0.155, P = 0.001). cPPinv was inversely related to Z-score (R = -0.271, P = 0.022) independently from age, mean blood pressure and heart rate (β = -0.241, P = 0.011)., Conclusion: Aortic root Z-score is inversely associated with invasively measured central pulse pressure in a cohort of patients undergoing invasive coronary assessment. Remodelling at the sinuses of Valsalva may be a compensatory mechanism to limit pulse pressure., (Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)

Published
2021
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49. Cardiovascular Organ Damage in Clinical Subtypes of Systemic Sclerosis: Arterial Stiffness and Echocardiography Might Not Be the Ideal Tools for Patient Risk Stratification.

Author

Avenatti E, Bruno G, Priora M, Parisi S, Ballini C, Veglio F, Milan A, and Fusaro E

Abstract

Background: Vascular damage is recognized as a diagnostic landmark in systemic sclerosis (SSc), both in its limited and diffuse subtypes. Early detection at a subclinical stage with transthoracic echocardiography (TTE) and carotid femoral pulse wave velocity (cfPWV) may be helpful in therapeutic planning and management. Aim of the Study . The aim of the study was to evaluate presence of subclinical cardiovascular damage in patients with limited and diffuse SSc in comparison with a cohort of healthy individuals., Methods: Consecutive patients with limited and diffuse SSc underwent complete TTE and cfPWV and a complete review of clinical data. As controls, 23 healthy subjects with similar hemodynamic profiles were selected., Results: 41 patients (35 female, aged 56.9 years), 21 with diffuse and 20 with limited SSc, were recruited. Past medical history, cardiovascular risk factors, gender distribution, and disease duration were similar in the two groups as well as TTE parameters and hemodynamic indexes-cfPWV (6.5 [6-6.8] vs. 7.0 [6.2-8.5], p =0.24) and augmentation index (145.6 ± 14.2 vs. 149 ± 20.6, p =0.52). Patients with limited SSc were 10 years older than patients with diffuse SSc. In the multiple regression analysis, only age ( p =0.0154) and disease duration ( p =0.0467) resulted as the significant determinant of cfPWV. When compared to healthy controls, no significant difference emerged in TTE or hemodynamic indexes., Conclusion: In SSc, cfPWV increases with age, with no additional impact of pathology or subtype. Vascular damage in the SSc population is not accurately reflected in increased arterial stiffness, as evaluated with cfPWV, or classically defined echocardiographic findings of organ damage (i.e., left ventricular concentric remodelling and increased filling pressures)., Competing Interests: The authors declare no conflicts of interest., (Copyright © 2021 Eleonora Avenatti et al.)

Published
2021
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50. Effects of Carfilzomib Therapy on Left Ventricular Function in Multiple Myeloma Patients.

Author

Mingrone G, Astarita A, Airale L, Maffei I, Cesareo M, Crea T, Bruno G, Leone D, Avenatti E, Catarinella C, Salvini M, Cetani G, Gay F, Bringhen S, Veglio F, Vallelonga F, and Milan A

Abstract

Background: Carfilzomib improves the prognosis of multiple myeloma (MM) patients but significantly increases cardiovascular toxicity. The timing and effect of Carfilzomib therapy on the left ventricular function is still under investigation. We sought to assess the echocardiographic systo-diastolic changes, including global longitudinal strain (GLS), in patients treated with Carfilzomib and to identify predictors of increased risk of cardiovascular adverse events (CVAEs) during therapy. Methods: Eighty-eight patients with MM performed a baseline cardiovascular evaluation comprehensive of transthoracic echocardiogram (TTE) before the start of Carfilzomib therapy and after 6 months. All patients were clinically followed up to early identify the occurrence of CVAEs during the whole therapy duration. Results: After Carfilzomib treatment, mean GLS slightly decreased (-22.2% ± 2.6 vs. -21.3% ± 2.5; p < 0.001). Fifty-eight percent of patients experienced CVAEs during therapy: 71% of them had uncontrolled hypertension, and 29% had major CVAEs or CV events not related to arterial hypertension. GLS variation during therapy was not related to an increased risk of CVAEs; however, patients with baseline GLS ≥ -21% and/or left ventricular ejection fraction (LVEF) ≤ 60% had a greater risk of major CVAEs (OR = 6.2, p = 0.004; OR = 3.7, p = 0.04, respectively). Carfilzomib led to a higher risk of diastolic dysfunction (5.6 vs. 13.4%, p = 0.04) and to a rise in E/e' ratio (8.9 ± 2.7 vs. 9.7 ± 3.7; p = 0.006). Conclusion: Carfilzomib leads to early LV function impairment early demonstrated by GLS changes and diastolic dysfunction. Baseline echocardiographic parameters, especially GLS and LVEF, might improve cardiovascular risk stratification before treatment., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Mingrone, Astarita, Airale, Maffei, Cesareo, Crea, Bruno, Leone, Avenatti, Catarinella, Salvini, Cetani, Gay, Bringhen, Veglio, Vallelonga and Milan.)

Published
2021
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