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1. Factors associated with undiagnosed diabetes among adults with diabetes: Results from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Author

Casagrande, Sarah Stark, Menke, Andy, Aviles-Santa, Larissa, Gallo, Linda C, Daviglus, Martha L, Talavera, Gregory A, Castañeda, Sheila F, Perreira, Krista, Loop, Matthew Shane, Tarraf, Wassim, González, Hector M, and Cowie, Catherine C

Subjects
Health Services and Systems, Public Health, Health Sciences, Prevention, Basic Behavioral and Social Science, Clinical Research, Health Services, Behavioral and Social Science, Diabetes, Metabolic and endocrine, Good Health and Well Being, Adult, Aged, Diabetes Mellitus, Female, Hispanic or Latino, Humans, Male, Middle Aged, Prevalence, Risk Factors, Undiagnosed diabetes, Hispanic/Latinos, Hispanic Community Health Study/Study of Latinos, Clinical Sciences, Public Health and Health Services, Psychology, Endocrinology & Metabolism, Clinical sciences, Public health, Clinical and health psychology
Abstract

AimsTo investigate sociodemographic and health factors associated with undiagnosed diabetes among adults with diabetes in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).MethodsAmong 3384 adults with self-reported diabetes or undiagnosed diabetes in the baseline HCHS/SOL, we estimated odds ratios (OR) of being undiagnosed for demographic, cultural, access to care, and health factors.ResultsAmong individuals with diabetes, 37.0% were undiagnosed. After adjustment and compared to people of Mexican heritage, people of Cuban and South American heritage had 60% (OR = 1.60, 95% CI = 1.02-2.50) and 91% (OR = 1.91, 1.16-3.14) higher odds of being undiagnosed, respectively. Individuals with a higher odds of being undiagnosed were women (OR = 1.64, 1.26-2.13), those with no health insurance (OR = 1.31, 1.00-1.71), individuals who received no healthcare in the past year (OR = 3.59, 2.49-5.16), those who were overweight (vs. normal weight) (OR = 1.60, 1.02-2.50), and those with dyslipidemia (OR = 1.38, 1.10-1.74). Individuals with lower odds of being undiagnosed were those with a family history of diabetes (OR = 0.54, 0.43-0.68), and those with hypertension (OR = 0.46, 0.36-0.58).ConclusionsVariation by Hispanic heritage group, sex, and access to medical care highlight where concentrated efforts are need to improve diabetes awareness. Our findings will inform clinical and public health practices to improve diabetes awareness among vulnerable populations.

Published
2018

2. Abstract 12720: Hypertension in the Dominican Population Living in the United States Enrolled in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Compared to Dominicans Living in the Dominican Republic: Understanding the Impact of Risk Factors

Author

Alvarez, Luisa, April-Sanders, Ayana K, Lee, Un Jung, herrera, cesar, Collado, Donaldo, Kaplan, Robert, Gonzalez, Franklyn, Daviglus, Martha L, Garcia, Olga, Elfassy, Tali, Schneiderman, Neil, Perreira, Krista, Aviles-Santa, Larissa, Talavera, Gregory A, Corsino, Leonor, and Rodriguez, Carlos

Published
2022
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3. Hispanics/Latinos With Type 2 Diabetes Have Functional and Symptomatic Pulmonary Impairment Mirroring Kidney Microangiopathy: Findings From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

Author

Klein, Oana L, Aviles-Santa, Larissa, Cai, Jianwen, Collard, Harold R, Kanaya, Alka M, Kaplan, Robert C, Kinney, Gregory L, Mendes, Eliana, Smith, Lewis, Talavera, Gregory, Wu, Donghong, and Daviglus, Martha

Subjects
Lung, Humans, Albuminuria, Diabetic Angiopathies, Diabetes Mellitus, Type 2, Forced Expiratory Volume, Linear Models, Risk Factors, Cross-Sectional Studies, Adolescent, Adult, Aged, Middle Aged, Female, Male, Renal Insufficiency, Young Adult, Hispanic or Latino, Clinical Research, Diabetes, Respiratory, Good Health and Well Being, Medical and Health Sciences, Endocrinology & Metabolism
Abstract

ObjectiveType 2 diabetes mellitus (DM) has been associated with lung dysfunction, but this association has not been explored in Hispanics/Latinos. The relation between diabetic nephropathy and lung function and symptoms has not been explored.Research design and methodsThe Hispanic Community Health Study/Study of Latinos (HCHS/SOL), a large, multicenter, observational study, recruited 16,415 participants aged 18-74 years (14,455 with complete data on variables of interest), between 2008 and 2011 from four U.S. communities through a two-stage area household probability design. Baseline measurements were used for analyses. Forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), and dyspnea score were compared between individuals with and without DM, overall, and stratified by albuminuria. The analyses were performed separately for those with and without preexisting lung disease (chronic bronchitis, emphysema, asthma). Linear regression with sampling weights was used for all analyses.ResultsAmong Hispanics/Latinos without lung disease, those with DM had lower mean FEV1 and FVC values and a higher mean dyspnea score than those without DM (mean [95% CI] FEV1 3.00 [2.96-3.04] vs. 3.10 [3.09-3.11] L, P < 0.01; FVC 3.62 [3.59-3.66] vs. 3.81 [3.79-3.83] L, P < 0.001; dyspnea score 0.60 [0.49-0.71] vs. 0.41 [0.34-0.49], P < 0.001). Hispanics/Latinos with DM and macroalbuminuria showed 10% lower FVC (P < 0.001), 6% lower FEV1 (P < 0.001), and 2.5-fold higher dyspnea score (P = 0.04) than those without DM and with normoalbuminuria. Similar findings but with higher impairment in FVC were found in Hispanics/Latinos with lung disease.ConclusionsHispanics/Latinos with DM have functional and symptomatic pulmonary impairment that mirror kidney microangiopathy. The progression of pulmonary impairment in adults with DM needs to be investigated further.

Published
2016

4. SMIM1 absence is associated with reduced energy expenditure and excess weight

Author

Banasik, Karina, Bay, Jakob, Boldsen, Jens Kjærgaard, Brodersen, Thorsten, Brunak, Søren, Burgdorf, Kristoffer, Chalmer, Mona Ameri, Didriksen, Maria, Dinh, Khoa Manh, Dowsett, Joseph, Erikstrup, Christian, Feenstra, Bjarke, Geller, Frank, Gudbjartsson, Daniel, Hansen, Thomas Folkmann, Hindhede, Lotte, Hjalgrim, Henrik, Jacobsen, Rikke Louise, Jemec, Gregor, Jensen, Bitten Aagaard, Kaspersen, Katrine, Kjerulff, Bertram Dalskov, Kogelman, Lisette, Hørup Larsen, Margit Anita, Louloudis, Ioannis, Lundgaard, Agnete, Susan, Mikkelsen, Christina, Nissen, Ioanna, Nyegaard, Mette, Ostrowski, Sisse Rye, Pedersen, Ole Birger, Henriksen, Alexander Pil, Rohde, Palle Duun, Rostgaard, Klaus, Schwinn, Michael, Stefansson, Kari, Stefánsson, Hreinn, Sørensen, Erik, þorsteinsdóttir, Unnur, Thørner, Lise Wegner, Bruun, Mie Topholm, Ullum, Henrik, Werge, Thomas, Westergaard, David, Chen, Ji, Spracklen, Cassandra N., Marenne, Gaëlle, Varshney, Arushi, Corbin, Laura J., Luan, Jian’an, Willems, Sara M., Wu, Ying, Zhang, Xiaoshuai, Horikoshi, Momoko, Boutin, Thibaud S., Mägi, Reedik, Waage, Johannes, Li-Gao, Ruifang, Katie Chan, Kei Hang, Yao, Jie, Anasanti, Mila D., Chu, Audrey Y., Claringbould, Annique, Heikkinen, Jani, Hong, Jaeyoung, Hottenga, Jouke-Jan, Huo, Shaofeng, Kaakinen, Marika A., Louie, Tin, März, Winfried, Moreno-Macias, Hortensia, Ndungu, Anne, Nelson, Sarah C., Nolte, Ilja M., North, Kari E., Raulerson, Chelsea K., Ray, Debashree, Rohde, Rebecca, Rybin, Denis, Schurmann, Claudia, Sim, Xueling, Southam, Loz, Stewart, Isobel D., Wang, Carol A., Wang, Yujie, Wu, Peitao, Zhang, Weihua, Ahluwalia, Tarunveer S., Appel, Emil V.R., Bielak, Lawrence F., Brody, Jennifer A., Burtt, Noël P., Cabrera, Claudia P., Cade, Brian E., Chai, Jin Fang, Chai, Xiaoran, Chang, Li-Ching, Chen, Chien-Hsiun, Chen, Brian H., Chitrala, Kumaraswamy Naidu, Chiu, Yen-Feng, de Haan, Hugoline G., Delgado, Graciela E., Demirkan, Ayse, Duan, Qing, Engmann, Jorgen, Fatumo, Segun A., Gayán, Javier, Giulianini, Franco, Gong, Jung Ho, Gustafsson, Stefan, Hai, Yang, Hartwig, Fernando P., He, Jing, Heianza, Yoriko, Huang, Tao, Huerta-Chagoya, Alicia, Hwang, Mi Yeong, Jensen, Richard A., Kawaguchi, Takahisa, Kentistou, Katherine A., Kim, Young Jin, Kleber, Marcus E., Kooner, Ishminder K., Lai, Shuiqing, Lange, Leslie A., Langefeld, Carl D., Lauzon, Marie, Li, Man, Ligthart, Symen, Liu, Jun, Loh, Marie, Long, Jirong, Lyssenko, Valeriya, Mangino, Massimo, Marzi, Carola, Montasser, May E., Nag, Abhishek, Nakatochi, Masahiro, Noce, Damia, Noordam, Raymond, Pistis, Giorgio, Preuss, Michael, Raffield, Laura, Rasmussen-Torvik, Laura J., Rich, Stephen S., Robertson, Neil R., Rueedi, Rico, Ryan, Kathleen, Sanna, Serena, Saxena, Richa, Schraut, Katharina E., Sennblad, Bengt, Setoh, Kazuya, Smith, Albert V., Southam, Lorraine, Sparsø, Thomas, Strawbridge, Rona J., Takeuchi, Fumihiko, Tan, Jingyi, Trompet, Stella, van den Akker, Erik, van der Most, Peter J., Verweij, Niek, Vogel, Mandy, Wang, Heming, Wang, Chaolong, Wang, Nan, Warren, Helen R., Wen, Wanqing, Wilsgaard, Tom, Wong, Andrew, Wood, Andrew R., Xie, Tian, Zafarmand, Mohammad Hadi, Zhao, Jing-Hua, Zhao, Wei, Amin, Najaf, Arzumanyan, Zorayr, Astrup, Arne, Bakker, Stephan J.L., Baldassarre, Damiano, Beekman, Marian, Bergman, Richard N., Bertoni, Alain, Blüher, Matthias, Bonnycastle, Lori L., Bornstein, Stefan R., Bowden, Donald W., Cai, Qiuyin, Campbell, Archie, Campbell, Harry, Chang, Yi Cheng, de Geus, Eco J.C., Dehghan, Abbas, Du, Shufa, Eiriksdottir, Gudny, Farmaki, Aliki Eleni, Frånberg, Mattias, Fuchsberger, Christian, Gao, Yutang, Gjesing, Anette P., Goel, Anuj, Han, Sohee, Hartman, Catharina A., Herder, Christian, Hicks, Andrew A., Hsieh, Chang-Hsun, Hsueh, Willa A., Ichihara, Sahoko, Igase, Michiya, Ikram, M. Arfan, Johnson, W. Craig, Jørgensen, Marit E., Joshi, Peter K., Kalyani, Rita R., Kandeel, Fouad R., Katsuya, Tomohiro, Khor, Chiea Chuen, Kiess, Wieland, Kolcic, Ivana, Kuulasmaa, Teemu, Kuusisto, Johanna, Läll, Kristi, Lam, Kelvin, Lawlor, Deborah A., Lee, Nanette R., Lemaitre, Rozenn N., Li, Honglan, Lin, Shih-Yi, Lindström, Jaana, Linneberg, Allan, Liu, Jianjun, Lorenzo, Carlos, Matsubara, Tatsuaki, Matsuda, Fumihiko, Mingrone, Geltrude, Mooijaart, Simon, Moon, Sanghoon, Nabika, Toru, Nadkarni, Girish N., Nadler, Jerry L., Nelis, Mari, Neville, Matt J., Norris, Jill M., Ohyagi, Yasumasa, Peters, Annette, Peyser, Patricia A., Polasek, Ozren, Qi, Qibin, Raven, Dennis, Reilly, Dermot F., Reiner, Alex, Rivideneira, Fernando, Roll, Kathryn, Rudan, Igor, Sabanayagam, Charumathi, Sandow, Kevin, Sattar, Naveed, Schürmann, Annette, Shi, Jinxiu, Stringham, Heather M., Taylor, Kent D., Teslovich, Tanya M., Thuesen, Betina, Timmers, Paul R.H.J., Tremoli, Elena, Tsai, Michael Y., Uitterlinden, Andre, van Dam, Rob M., van Heemst, Diana, van Hylckama Vlieg, Astrid, Van Vliet-Ostaptchouk, Jana V., Vangipurapu, Jagadish, Vestergaard, Henrik, Wang, Tao, Willems van Dijk, Ko, Zemunik, Tatijana, Abecasis, Goncalo R., Adair, Linda S., Aguilar-Salinas, Carlos Alberto, Alarcón-Riquelme, Marta E., An, Ping, Aviles-Santa, Larissa, Becker, Diane M., Beilin, Lawrence J., Bergmann, Sven, Bisgaard, Hans, Black, Corri, Boehnke, Michael, Boerwinkle, Eric, Böhm, Bernhard O., Bønnelykke, Klaus, Boomsma, D.I., Bottinger, Erwin P., Buchanan, Thomas A., Canouil, Mickaël, Caulfield, Mark J., Chambers, John C., Chasman, Daniel I., Ida Chen, Yii-Der, Cheng, Ching-Yu, Collins, Francis S., Correa, Adolfo, Cucca, Francesco, Janaka de Silva, H., Dedoussis, George, Elmståhl, Sölve, Evans, Michele K., Ferrannini, Ele, Ferrucci, Luigi, Florez, Jose C., Franks, Paul W., Frayling, Timothy M., Froguel, Philippe, Gigante, Bruna, Goodarzi, Mark O., Gordon-Larsen, Penny, Grallert, Harald, Grarup, Niels, Grimsgaard, Sameline, Groop, Leif, Gudnason, Vilmundur, Guo, Xiuqing, Hamsten, Anders, Hansen, Torben, Hayward, Caroline, Heckbert, Susan R., Horta, Bernardo L., Huang, Wei, Ingelsson, Erik, James, Pankow S., Jarvelin, Marjo-Ritta, Jonas, Jost B., Jukema, J. Wouter, Kaleebu, Pontiano, Kaplan, Robert, Kardia, Sharon L.R., Kato, Norihiro, Keinanen-Kiukaanniemi, Sirkka M., Kim, Bong-Jo, Kivimaki, Mika, Koistinen, Heikki A., Kooner, Jaspal S., Körner, Antje, Kovacs, Peter, Kuh, Diana, Kumari, Meena, Kutalik, Zoltan, Laakso, Markku, Lakka, Timo A., Launer, Lenore J., Leander, Karin, Li, Huaixing, Lin, Xu, Lind, Lars, Lindgren, Cecilia, Liu, Simin, Loos, Ruth J.F., Magnusson, Patrik K.E., Mahajan, Anubha, Metspalu, Andres, Mook-Kanamori, Dennis O., Mori, Trevor A., Munroe, Patricia B., Njølstad, Inger, O'Connell, Jeffrey R., Oldehinkel, Albertine J., Ong, Ken K., Padmanabhan, Sandosh, Palmer, Colin N.A., Palmer, Nicholette D., Pedersen, Oluf, Pennell, Craig E., Porteous, David J., Pramstaller, Peter P., Province, Michael A., Psaty, Bruce M., Qi, Lu, Raffel, Leslie J., Rauramaa, Rainer, Redline, Susan, Ridker, Paul M., Rosendaal, Frits R., Saaristo, Timo E., Sandhu, Manjinder, Saramies, Jouko, Schneiderman, Neil, Schwarz, Peter, Scott, Laura J., Selvin, Elizabeth, Sever, Peter, Shu, Xiao-Ou, Slagboom, P. Eline, Small, Kerrin S., Smith, Blair H., Snieder, Harold, Sofer, Tamar, Sørensen, Thorkild I.A., Spector, Tim D., Stanton, Alice, Steves, Claire J., Stumvoll, Michael, Sun, Liang, Tabara, Yasuharu, Tai, E. Shyong, Timpson, Nicholas J., Tönjes, Anke, Tuomilehto, Jaakko, Tusie, Teresa, Uusitupa, Matti, van der Harst, Pim, van Duijn, Cornelia, Vitart, Veronique, Vollenweider, Peter, Vrijkotte, Tanja G.M., Wagenknecht, Lynne E., Walker, Mark, Wang, Ya X., Wareham, Nick J., Watanabe, Richard M., Watkins, Hugh, Wei, Wen B., Wickremasinghe, Ananda R., Willemsen, Gonneke, Wilson, James F., Wong, Tien-Yin, Wu, Jer-Yuarn, Xiang, Anny H., Yanek, Lisa R., Yengo, Loïc, Yokota, Mitsuhiro, Zeggini, Eleftheria, Zheng, Wei, Zonderman, Alan B., Rotter, Jerome I., Gloyn, Anna L., McCarthy, Mark I., Dupuis, Josée, Meigs, James B., Scott, Robert A., Prokopenko, Inga, Leong, Aaron, Liu, Ching-Ti, Parker, Stephen C.J., Mohlke, Karen L., Langenberg, Claudia, Wheeler, Eleanor, Morris, Andrew P., Barroso, Inês, Stefanucci, Luca, Moslemi, Camous, Tomé, Ana R., Virtue, Samuel, Bidault, Guillaume, Gleadall, Nicholas S., Watson, Laura P.E., Kwa, Jing E., Burden, Frances, Farrow, Samantha, Võsa, Urmo, Burling, Keith, Walker, Lindsay, Ord, John, Barker, Peter, Warner, James, Frary, Amy, Renhstrom, Karola, Ashford, Sofie E., Piper, Jo, Biggs, Gail, Erber, Wendy N., Hoffman, Gary J., Schoenmakers, Nadia, Rieneck, Klaus, Dziegiel, Morten H., Azzu, Vian, Vacca, Michele, Aparicio, Hugo Javier, Hui, Qin, Cho, Kelly, Sun, Yan V., Wilson, Peter W., Bayraktar, Omer A., Vidal-Puig, Antonio, Ostrowski, Sisse R., Astle, William J., Olsson, Martin L., Storry, Jill R., Pedersen, Ole B., Ouwehand, Willem H., Chatterjee, Krishna, Vuckovic, Dragana, and Frontini, Mattia

Published
2024
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7. Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality

Author

Magnussen, C, Ojeda, F, Leong, D, Alegre-Diaz, J, Amouyel, P, Aviles-Santa, L, De Bacquer, D, Ballantyne, C, Bernabé-Ortiz, A, Bobak, M, Brenner, H, Carrillo-Larco, R, de Lemos, J, Dobson, A, Dörr, M, Donfrancesco, C, Drygas, W, Dullaart, R, Engström, G, Ferrario, M, Ferrières, J, de Gaetano, G, Goldbourt, U, Gonzalez, C, Grassi, G, Hodge, A, Hveem, K, Iacoviello, L, Ikram, M, Irazola, V, Jobe, M, Jousilahti, P, Kaleebu, P, Kavousi, M, Kee, F, Khalili, D, Koenig, W, Kontsevaya, A, Kuulasmaa, K, Lackner, K, Leistner, D, Lind, L, Linneberg, A, Lorenz, T, Lyngbakken, M, Malekzadeh, R, Malyutina, S, Mathiesen, E, Melander, O, Metspalu, A, Miranda, J, Moitry, M, Mugisha, J, Nalini, M, Nambi, V, Ninomiya, T, Oppermann, K, D'Orsi, E, Pająk, A, Palmieri, L, Panagiotakos, D, Perianayagam, A, Peters, A, Poustchi, H, Prentice, A, Prescott, E, Risérus, U, Salomaa, V, Sans, S, Sakata, S, Schöttker, B, Schutte, A, Sepanlou, S, Sharma, S, Shaw, J, Simons, L, Söderberg, S, Tamosiunas, A, Thorand, B, Tunstall-Pedoe, H, Twerenbold, R, Vanuzzo, D, Veronesi, G, Waibel, J, Wannamethee, S, Watanabe, M, Wild, P, Yao, Y, Zeng, Y, Ziegler, A, Blankenberg, S, Magnussen, Christina, Ojeda, Francisco M, Leong, Darryl P, Alegre-Diaz, Jesus, Amouyel, Philippe, Aviles-Santa, Larissa, De Bacquer, Dirk, Ballantyne, Christie M, Bernabé-Ortiz, Antonio, Bobak, Martin, Brenner, Hermann, Carrillo-Larco, Rodrigo M, de Lemos, James, Dobson, Annette, Dörr, Marcus, Donfrancesco, Chiara, Drygas, Wojciech, Dullaart, Robin P, Engström, Gunnar, Ferrario, Marco M, Ferrières, Jean, de Gaetano, Giovanni, Goldbourt, Uri, Gonzalez, Clicerio, Grassi, Guido, Hodge, Allison M, Hveem, Kristian, Iacoviello, Licia, Ikram, M Kamran, Irazola, Vilma, Jobe, Modou, Jousilahti, Pekka, Kaleebu, Pontiano, Kavousi, Maryam, Kee, Frank, Khalili, Davood, Koenig, Wolfgang, Kontsevaya, Anna, Kuulasmaa, Kari, Lackner, Karl J, Leistner, David M, Lind, Lars, Linneberg, Allan, Lorenz, Thiess, Lyngbakken, Magnus Nakrem, Malekzadeh, Reza, Malyutina, Sofia, Mathiesen, Ellisiv B, Melander, Olle, Metspalu, Andres, Miranda, J Jaime, Moitry, Marie, Mugisha, Joseph, Nalini, Mahdi, Nambi, Vijay, Ninomiya, Toshiharu, Oppermann, Karen, d'Orsi, Eleonora, Pająk, Andrzej, Palmieri, Luigi, Panagiotakos, Demosthenes, Perianayagam, Arokiasamy, Peters, Annette, Poustchi, Hossein, Prentice, Andrew M, Prescott, Eva, Risérus, Ulf, Salomaa, Veikko, Sans, Susana, Sakata, Satoko, Schöttker, Ben, Schutte, Aletta E, Sepanlou, Sadaf G, Sharma, Sanjib Kumar, Shaw, Jonathan E, Simons, Leon A, Söderberg, Stefan, Tamosiunas, Abdonas, Thorand, Barbara, Tunstall-Pedoe, Hugh, Twerenbold, Raphael, Vanuzzo, Diego, Veronesi, Giovanni, Waibel, Julia, Wannamethee, S Goya, Watanabe, Masafumi, Wild, Philipp S, Yao, Yao, Zeng, Yi, Ziegler, Andreas, Blankenberg, Stefan, Magnussen, C, Ojeda, F, Leong, D, Alegre-Diaz, J, Amouyel, P, Aviles-Santa, L, De Bacquer, D, Ballantyne, C, Bernabé-Ortiz, A, Bobak, M, Brenner, H, Carrillo-Larco, R, de Lemos, J, Dobson, A, Dörr, M, Donfrancesco, C, Drygas, W, Dullaart, R, Engström, G, Ferrario, M, Ferrières, J, de Gaetano, G, Goldbourt, U, Gonzalez, C, Grassi, G, Hodge, A, Hveem, K, Iacoviello, L, Ikram, M, Irazola, V, Jobe, M, Jousilahti, P, Kaleebu, P, Kavousi, M, Kee, F, Khalili, D, Koenig, W, Kontsevaya, A, Kuulasmaa, K, Lackner, K, Leistner, D, Lind, L, Linneberg, A, Lorenz, T, Lyngbakken, M, Malekzadeh, R, Malyutina, S, Mathiesen, E, Melander, O, Metspalu, A, Miranda, J, Moitry, M, Mugisha, J, Nalini, M, Nambi, V, Ninomiya, T, Oppermann, K, D'Orsi, E, Pająk, A, Palmieri, L, Panagiotakos, D, Perianayagam, A, Peters, A, Poustchi, H, Prentice, A, Prescott, E, Risérus, U, Salomaa, V, Sans, S, Sakata, S, Schöttker, B, Schutte, A, Sepanlou, S, Sharma, S, Shaw, J, Simons, L, Söderberg, S, Tamosiunas, A, Thorand, B, Tunstall-Pedoe, H, Twerenbold, R, Vanuzzo, D, Veronesi, G, Waibel, J, Wannamethee, S, Watanabe, M, Wild, P, Yao, Y, Zeng, Y, Ziegler, A, Blankenberg, S, Magnussen, Christina, Ojeda, Francisco M, Leong, Darryl P, Alegre-Diaz, Jesus, Amouyel, Philippe, Aviles-Santa, Larissa, De Bacquer, Dirk, Ballantyne, Christie M, Bernabé-Ortiz, Antonio, Bobak, Martin, Brenner, Hermann, Carrillo-Larco, Rodrigo M, de Lemos, James, Dobson, Annette, Dörr, Marcus, Donfrancesco, Chiara, Drygas, Wojciech, Dullaart, Robin P, Engström, Gunnar, Ferrario, Marco M, Ferrières, Jean, de Gaetano, Giovanni, Goldbourt, Uri, Gonzalez, Clicerio, Grassi, Guido, Hodge, Allison M, Hveem, Kristian, Iacoviello, Licia, Ikram, M Kamran, Irazola, Vilma, Jobe, Modou, Jousilahti, Pekka, Kaleebu, Pontiano, Kavousi, Maryam, Kee, Frank, Khalili, Davood, Koenig, Wolfgang, Kontsevaya, Anna, Kuulasmaa, Kari, Lackner, Karl J, Leistner, David M, Lind, Lars, Linneberg, Allan, Lorenz, Thiess, Lyngbakken, Magnus Nakrem, Malekzadeh, Reza, Malyutina, Sofia, Mathiesen, Ellisiv B, Melander, Olle, Metspalu, Andres, Miranda, J Jaime, Moitry, Marie, Mugisha, Joseph, Nalini, Mahdi, Nambi, Vijay, Ninomiya, Toshiharu, Oppermann, Karen, d'Orsi, Eleonora, Pająk, Andrzej, Palmieri, Luigi, Panagiotakos, Demosthenes, Perianayagam, Arokiasamy, Peters, Annette, Poustchi, Hossein, Prentice, Andrew M, Prescott, Eva, Risérus, Ulf, Salomaa, Veikko, Sans, Susana, Sakata, Satoko, Schöttker, Ben, Schutte, Aletta E, Sepanlou, Sadaf G, Sharma, Sanjib Kumar, Shaw, Jonathan E, Simons, Leon A, Söderberg, Stefan, Tamosiunas, Abdonas, Thorand, Barbara, Tunstall-Pedoe, Hugh, Twerenbold, Raphael, Vanuzzo, Diego, Veronesi, Giovanni, Waibel, Julia, Wannamethee, S Goya, Watanabe, Masafumi, Wild, Philipp S, Yao, Yao, Zeng, Yi, Ziegler, Andreas, and Blankenberg, Stefan

Abstract

BACKGROUND: Five modifiable risk factors are associated with cardiovascular disease and death from any cause. Studies using individual-level data to evaluate the regional and sex-specific prevalence of the risk factors and their effect on these outcomes are lacking. METHODS: We pooled and harmonized individual-level data from 112 cohort studies conducted in 34 countries and 8 geographic regions participating in the Global Cardiovascular Risk Consortium. We examined associations between the risk factors (body-mass index, systolic blood pressure, non-high-density lipoprotein cholesterol, current smoking, and diabetes) and incident cardiovascular disease and death from any cause using Cox regression analyses, stratified according to geographic region, age, and sex. Population-attributable fractions were estimated for the 10-year incidence of cardiovascular disease and 10-year all-cause mortality. RESULTS: Among 1,518,028 participants (54.1% of whom were women) with a median age of 54.4 years, regional variations in the prevalence of the five modifiable risk factors were noted. Incident cardiovascular disease occurred in 80,596 participants during a median follow-up of 7.3 years (maximum, 47.3), and 177,369 participants died during a median follow-up of 8.7 years (maximum, 47.6). For all five risk factors combined, the aggregate global population-attributable fraction of the 10-year incidence of cardiovascular disease was 57.2% (95% confidence interval [CI], 52.4 to 62.1) among women and 52.6% (95% CI, 49.0 to 56.1) among men, and the corresponding values for 10-year all-cause mortality were 22.2% (95% CI, 16.8 to 27.5) and 19.1% (95% CI, 14.6 to 23.6). CONCLUSIONS: Harmonized individual-level data from a global cohort showed that 57.2% and 52.6% of cases of incident cardiovascular disease among women and men, respectively, and 22.2% and 19.1% of deaths from any cause among women and men, respectively, may be attributable to five modifiable risk factors. (Funded by the

Published
2023

8. Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality.

Author

Magnussen, Christina, Ojeda, Francisco M., Leong, Darryl P., Alegre-Diaz, Jesus, Amouyel, Philippe, Aviles-Santa, Larissa, De Bacquer, Dirk, Ballantyne, Christie M., Bernabé-Ortiz, Antonio, Bobak, Martin, Brenner, Hermann, Carrillo-Larco, Rodrigo M., De Lemos, James, Dobson, Annette, Dörr, Marcus, Donfrancesco, Chiara, Drygas, Wojciech, Dullaart, Robin P., Engström, Gunnar, Ferrario, Marco M., Ferrières, Jean, De Gaetano, Giovanni, Goldbourt, Uri, Gonzalez, Clicerio, Grassi, Guido, Hodge, Allison M., Hveem, Kristian, Iacoviello, Licia, Ikram, M. Kamran, Irazola, Vilma, Jobe, Modou, Jousilahti, Pekka, Kaleebu, Pontiano, Kavousi, Maryam, Kee, Frank, Khalili, Davood, Koenig, Wolfgang, Kontsevaya, Anna, Kuulasmaa, Kari, Lackner, Karl J., Leistner, David M., Lind, Lars, Linneberg, Allan, Lorenz, Thiess, Lyngbakken, Magnus Nakrem, Malekzadeh, Reza, Malyutina, Sofia, Mathiesen, Ellisiv B., Melander, Olle, Metspalu, Andres, Miranda, J. Jaime, Moitry, Marie, Mugisha, Joseph, Nalini, Mahdi, Nambi, Vijay, Ninomiya, Toshiharu, Oppermann, Karen, D'Orsi, Eleonora, Pająk, Andrzej, Palmieri, Luigi, Panagiotakos, Demosthenes, Perianayagam, Arokiasamy, Peters, Annette, Poustchi, Hossein, Prentice, Andrew M., Prescott, Eva, Risérus, Ulf, Salomaa, Veikko, Sans, Susana, Sakata, Satoko, Schöttker, Ben, Schutte, Aletta E., Sepanlou, Sadaf G., Sharma, Sanjib Kumar, Shaw, Jonathan E., Simons, Leon A., Söderberg, Stefan, Tamosiunas, Abdonas, Thorand, Barbara, Tunstall-Pedoe, Hugh, Twerenbold, Raphael, Vanuzzo, Diego, Veronesi, Giovanni, Waibel, Julia, Wannamethee, S. Goya, Watanabe, Masafumi, Wild, Philipp S., Yao, Yao, Zeng, Yi, Ziegler, Andreas, Blankenberg, Stefan, Magnussen, Christina, Ojeda, Francisco M., Leong, Darryl P., Alegre-Diaz, Jesus, Amouyel, Philippe, Aviles-Santa, Larissa, De Bacquer, Dirk, Ballantyne, Christie M., Bernabé-Ortiz, Antonio, Bobak, Martin, Brenner, Hermann, Carrillo-Larco, Rodrigo M., De Lemos, James, Dobson, Annette, Dörr, Marcus, Donfrancesco, Chiara, Drygas, Wojciech, Dullaart, Robin P., Engström, Gunnar, Ferrario, Marco M., Ferrières, Jean, De Gaetano, Giovanni, Goldbourt, Uri, Gonzalez, Clicerio, Grassi, Guido, Hodge, Allison M., Hveem, Kristian, Iacoviello, Licia, Ikram, M. Kamran, Irazola, Vilma, Jobe, Modou, Jousilahti, Pekka, Kaleebu, Pontiano, Kavousi, Maryam, Kee, Frank, Khalili, Davood, Koenig, Wolfgang, Kontsevaya, Anna, Kuulasmaa, Kari, Lackner, Karl J., Leistner, David M., Lind, Lars, Linneberg, Allan, Lorenz, Thiess, Lyngbakken, Magnus Nakrem, Malekzadeh, Reza, Malyutina, Sofia, Mathiesen, Ellisiv B., Melander, Olle, Metspalu, Andres, Miranda, J. Jaime, Moitry, Marie, Mugisha, Joseph, Nalini, Mahdi, Nambi, Vijay, Ninomiya, Toshiharu, Oppermann, Karen, D'Orsi, Eleonora, Pająk, Andrzej, Palmieri, Luigi, Panagiotakos, Demosthenes, Perianayagam, Arokiasamy, Peters, Annette, Poustchi, Hossein, Prentice, Andrew M., Prescott, Eva, Risérus, Ulf, Salomaa, Veikko, Sans, Susana, Sakata, Satoko, Schöttker, Ben, Schutte, Aletta E., Sepanlou, Sadaf G., Sharma, Sanjib Kumar, Shaw, Jonathan E., Simons, Leon A., Söderberg, Stefan, Tamosiunas, Abdonas, Thorand, Barbara, Tunstall-Pedoe, Hugh, Twerenbold, Raphael, Vanuzzo, Diego, Veronesi, Giovanni, Waibel, Julia, Wannamethee, S. Goya, Watanabe, Masafumi, Wild, Philipp S., Yao, Yao, Zeng, Yi, Ziegler, Andreas, and Blankenberg, Stefan

Abstract

BACKGROUND Five modifiable risk factors are associated with cardiovascular disease and death from any cause. Studies using individual-level data to evaluate the regional and sex-specific prevalence of the risk factors and their effect on these outcomes are lacking. METHODS We pooled and harmonized individual-level data from 112 cohort studies conducted in 34 countries and 8 geographic regions participating in the Global Cardiovascular Risk Consortium. We examined associations between the risk factors (body-mass index, systolic blood pressure, non–high-density lipoprotein cholesterol, current smoking, and diabetes) and incident cardiovascular disease and death from any cause using Cox regression analyses, stratified according to geographic region, age, and sex. Population-attributable fractions were estimated for the 10-year incidence of cardiovascular disease and 10-year all-cause mortality. RESULTS Among 1,518,028 participants (54.1% of whom were women) with a median age of 54.4 years, regional variations in the prevalence of the five modifiable risk factors were noted. Incident cardiovascular disease occurred in 80,596 participants during a median follow-up of 7.3 years (maximum, 47.3), and 177,369 participants died during a median follow-up of 8.7 years (maximum, 47.6). For all five risk factors combined, the aggregate global population-attributable fraction of the 10-year incidence of cardiovascular disease was 57.2% (95% confidence interval [CI], 52.4 to 62.1) among women and 52.6% (95% CI, 49.0 to 56.1) among men, and the corresponding values for 10-year all-cause mortality were 22.2% (95% CI, 16.8 to 27.5) and 19.1% (95% CI, 14.6 to 23.6). CONCLUSIONS Harmonized individual-level data from a global cohort showed that 57.2% and 52.6% of cases of incident cardiovascular disease among women and men, respectively, and 22.2% and 19.1% of deaths from any cause among women and men, respectively, may be attributable to f, Background Five modifiable risk factors are associated with cardiovascular disease and death from any cause. Studies using individual-level data to evaluate the regional and sex-specific prevalence of the risk factors and their effect on these outcomes are lacking. Methods We pooled and harmonized individual-level data from 112 cohort studies conducted in 34 countries and 8 geographic regions participating in the Global Cardiovascular Risk Consortium. We examined associations between the risk factors (body-mass index, systolic blood pressure, non-high-density lipoprotein cholesterol, current smoking, and diabetes) and incident cardiovascular disease and death from any cause using Cox regression analyses, stratified according to geographic region, age, and sex. Population-attributable fractions were estimated for the 10-year incidence of cardiovascular disease and 10-year all-cause mortality. Results Among 1,518,028 participants (54.1% of whom were women) with a median age of 54.4 years, regional variations in the prevalence of the five modifiable risk factors were noted. Incident cardiovascular disease occurred in 80,596 participants during a median follow-up of 7.3 years (maximum, 47.3), and 177,369 participants died during a median follow-up of 8.7 years (maximum, 47.6). For all five risk factors combined, the aggregate global population-attributable fraction of the 10-year incidence of cardiovascular disease was 57.2% (95% confidence interval [CI], 52.4 to 62.1) among women and 52.6% (95% CI, 49.0 to 56.1) among men, and the corresponding values for 10-year all-cause mortality were 22.2% (95% CI, 16.8 to 27.5) and 19.1% (95% CI, 14.6 to 23.6). Conclusions Harmonized individual-level data from a global cohort showed that 57.2% and 52.6% of cases of incident cardiovascular disease among women and men, respectively, and 22.2% and 19.1% of deaths from any cause among women and men, respectively, may be attributable to five modifiable risk factors. (Funded by the G

Published
2023

10. Hypertension in the Dominican Population Living in the United States Enrolled in the HCHS/SOL Compared to Dominicans Living in the Dominican Republic Enrolled in the ENPREFAR-HAS 17: Understanding the Impact of Risk Factors

Author

Alvarez, Luisa, primary, April-Sanders, Ayana, additional, Duran Luciano, Priscilla, additional, Lee, Un Jung, additional, Swett, Katrina, additional, Herrera, Cesar, additional, Collado, Donaldo, additional, Kaplan, Robert, additional, Gonzalez II, Franklyn, additional, Daviglus, Martha, additional, Garcia-Bedoya, Olga, additional, Elfassy, Tali, additional, Schneiderman, Neil, additional, Perreira, Krista M., additional, Aviles-Santa, Larissa, additional, Talavera, Gregory A., additional, Corsino, Leonor, additional, and Rodriguez, Carlos J., additional

Published
2023
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11. Neighborhood segregation and cancer prevention guideline adherence in US Hispanic/Latino adults: Results from the HCHS/SOL

Author

Pichardo, Margaret S., primary, Pichardo, Catherine M., additional, Talavera, Gregory A., additional, Gallo, Linda C., additional, Castañeda, Sheila F., additional, Sotres-Alvarez, Daniela, additional, Molina, Yamile, additional, Evenson, Kelly R., additional, Daviglus, Martha L., additional, Hou, Lifang, additional, Joyce, Brian, additional, Aviles-Santa, Larissa, additional, and Plascak, Jesse, additional

Published
2022
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12. Preconception Cardiometabolic Markers and Birth Outcomes Among Women in the Hispanic Community Health Study/Study of Latinos

Author

Vladutiu, Catherine J., primary, Butera, Nicole M., additional, Sotres-Alvarez, Daniela, additional, Stuebe, Alison M., additional, Aviles-Santa, Larissa, additional, Daviglus, Martha L., additional, Gellman, Marc D., additional, Isasi, Carmen R., additional, Cordero, Christina, additional, Talavera, Gregory A., additional, Van Horn, Linda, additional, and Siega-Riz, Anna Maria, additional

Published
2022
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13. Abstract 739: Adherence to the lifestyle guidelines among Hispanic/Latino adults vary by physical activity measures

Author

Pichardo, Margaret Saira, primary, Pichardo, Catherine, additional, Castañeda, Sheila F., additional, Molina, Yamile, additional, Evenson, Kelly R., additional, Daviglus, Martha, additional, Hou, Lifang, additional, Sotres-Alvarez, Daniela, additional, Copello, Tatiana Gomez, additional, Joyce, Brian, additional, Aviles-Santa, Larissa, additional, Talavera, Gregory A., additional, Gallo, Linda C., additional, and Plascak, Jesse, additional

Published
2022
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16. The trans-ancestral genomic architecture of glycemic traits

Author

Chen, Ji, Spracklen, Cassandra N., Marenne, Gaëlle, Varshney, Arushi, Corbin, Laura J., Luan, Jian'an, Willems, Sara M., Wu, Ying, Zhang, Xiaoshuai, Horikoshi, Momoko, Boutin, Thibaud S., Mägi, Reedik, Waage, Johannes, Li-Gao, Ruifang, Chan, Kei Hang Katie, Yao, Jie, Anasanti, Mila D., Chu, Audrey Y., Claringbould, Annique, Heikkinen, Jani, Hong, Jaeyoung, Hottenga, Jouke-Jan, Huo, Shaofeng, Kaakinen, Marika A., Louie, Tin, März, Winfried, Moreno-Macias, Hortensia, Ndungu, Anne, Nelson, Sarah C., Nolte, Ilja M., North, Kari E., Raulerson, Chelsea K., Ray, Debashree, Rohde, Rebecca, Rybin, Denis, Schurmann, Claudia, Sim, Xueling, Southam, Lorraine, Stewart, Isobel D., Wang, Carol A., Wang, Yujie, Wu, Peitao, Zhang, Weihua, Ahluwalia, Tarunveer S., Appel, Emil V R, Bielak, Lawrence F., Brody, Jennifer A., Burtt, Noël P, Cabrera, Claudia P., Cade, Brian E., Chai, Jin Fang, Chai, Xiaoran, Chang, Li-Ching, Chen, Chien-Hsiun, Chen, Brian H., Chitrala, Kumaraswamy Naidu, Chiu, Yen-Feng, de Haan, Hugoline G., Delgado, Graciela E., Demirkan, Ayse, Duan, Qing, Engmann, Jorgen, Fatumo, Segun A., Gayán, Javier, Giulianini, Franco, Gong, Jung Ho, Gustafsson, Stefan, Hai, Yang, Hartwig, Fernando P., He, Jing, Heianza, Yoriko, Huang, Tao, Huerta-Chagoya, Alicia, Hwang, Mi Yeong, Jensen, Richard A., Kawaguchi, Takahisa, Kentistou, Katherine A., Kim, Young Jin, Kleber, Marcus E., Kooner, Ishminder K., Lai, Shuiqing, Lange, Leslie A., Langefeld, Carl D., Lauzon, Marie, Li, Man, Ligthart, Symen, Liu, Jun, Loh, Marie, Long, Jirong, Lyssenko, Valeriya, Mangino, Massimo, Marzi, Carola, Montasser, May E., Nag, Abhishek, Nakatochi, Masahiro, Noce, Damia, Noordam, Raymond, Pistis, Giorgio, Preuss, Michael, Raffield, Laura, Rasmussen-Torvik, Laura J., Rich, Stephen S., Robertson, Neil R., Rueedi, Rico, Ryan, Kathleen, Sanna, Serena, Saxena, Richa, Schraut, Katharina E., Sennblad, Bengt, Setoh, Kazuya, Smith, Albert V., Sparsø, Thomas, Strawbridge, Rona J., Takeuchi, Fumihiko, Tan, Jingyi, Trompet, Stella, van den Akker, Erik, van der Most, Peter J., Verweij, Niek, Vogel, Mandy, Wang, Heming, Wang, Chaolong, Wang, Nan, Warren, Helen R., Wen, Wanqing, Wilsgaard, Tom, Wong, Andrew, Wood, Andrew R., Xie, Tian, Zafarmand, Mohammad Hadi, Zhao, Jing-Hua, Zhao, Wei, Amin, Najaf, Arzumanyan, Zorayr, Astrup, Arne, Bakker, Stephan J L, Baldassarre, Damiano, Beekman, Marian, Bergman, Richard N., Bertoni, Alain, Blüher, Matthias, Bonnycastle, Lori L., Bornstein, Stefan R., Bowden, Donald W., Cai, Qiuyin, Campbell, Archie, Campbell, Harry, Chang, Yi Cheng, de Geus, Eco J C, Dehghan, Abbas, Du, Shufa, Eiriksdottir, Gudny, Farmaki, Aliki Eleni, Frånberg, Mattias, Fuchsberger, Christian, Gao, Yutang, Gjesing, Anette P., Goel, Anuj, Han, Sohee, Hartman, Catharina A., Herder, Christian, Hicks, Andrew A., Hsieh, Chang-Hsun, Hsueh, Willa A., Ichihara, Sahoko, Igase, Michiya, Ikram, M Arfan, Johnson, W Craig, Jørgensen, Marit E., Joshi, Peter K., Kalyani, Rita R., Kandeel, Fouad R., Katsuya, Tomohiro, Khor, Chiea Chuen, Kiess, Wieland, Kolcic, Ivana, Kuulasmaa, Teemu, Kuusisto, Johanna, Läll, Kristi, Lam, Kelvin, Lawlor, Deborah A., Lee, Nanette R., Lemaitre, Rozenn N., Li, Honglan, Lin, Shih-Yi, Lindström, Jaana, Linneberg, Allan, Liu, Jianjun, Lorenzo, Carlos, Matsubara, Tatsuaki, Matsuda, Fumihiko, Mingrone, Geltrude, Mooijaart, Simon, Moon, Sanghoon, Nabika, Toru, Nadkarni, Girish N., Nadler, Jerry L., Nelis, Mari, Neville, Matt J., Norris, Jill M., Ohyagi, Yasumasa, Peters, Annette, Peyser, Patricia A., Polasek, Ozren, Qi, Qibin, Raven, Dennis, Reilly, Dermot F., Reiner, Alex, Rivideneira, Fernando, Roll, Kathryn, Rudan, Igor, Sabanayagam, Charumathi, Sandow, Kevin, Sattar, Naveed, Schürmann, Annette, Shi, Jinxiu, Stringham, Heather M., Taylor, Kent D., Teslovich, Tanya M., Thuesen, Betina, Timmers, Paul R H J, Tremoli, Elena, Tsai, Michael Y., Uitterlinden, Andre, van Dam, Rob M., van Heemst, Diana, van Hylckama Vlieg, Astrid, van Vliet-Ostaptchouk, Jana V., Vangipurapu, Jagadish, Vestergaard, Henrik, Wang, Tao, Willems van Dijk, Ko, Zemunik, Tatijana, Abecasis, Gonçalo R, Adair, Linda S., Aguilar-Salinas, Carlos Alberto, Alarcón-Riquelme, Marta E., An, Ping, Aviles-Santa, Larissa, Becker, Diane M., Beilin, Lawrence J., Bergmann, Sven, Bisgaard, Hans, Black, Corri, Boehnke, Michael, Boerwinkle, Eric, Böhm, Bernhard O., Bønnelykke, Klaus, Boomsma, D.I., Bottinger, Erwin P., Buchanan, Thomas A., Canouil, Mickaël, Caulfield, Mark J., Chambers, John C., Chasman, Daniel I., Chen, Yii-Der Ida, Cheng, Ching-Yu, Collins, Francis S., Correa, Adolfo, Cucca, Francesco, de Silva, H Janaka, Dedoussis, George, Elmståhl, Sölve, Evans, Michele K., Ferrannini, Ele, Ferrucci, Luigi, Florez, Jose C., Franks, Paul W., Frayling, Timothy M., Froguel, Philippe, Gigante, Bruna, Goodarzi, Mark O., Gordon-Larsen, Penny, Grallert, Harald, Grarup, Niels, Grimsgaard, Sameline, Groop, Leif, Gudnason, Vilmundur, Guo, Xiuqing, Hamsten, Anders, Hansen, Torben, Hayward, Caroline, Heckbert, Susan R., Horta, Bernardo L., Huang, Wei, Ingelsson, Erik, James, Pankow S., Jarvelin, Marjo-Ritta, Jonas, Jost B., Jukema, J Wouter, Kaleebu, Pontiano, Kaplan, Robert, Kardia, Sharon L R, Kato, Norihiro, Keinanen-Kiukaanniemi, Sirkka M., Kim, Bong-Jo, Kivimaki, Mika, Koistinen, Heikki A., Kooner, Jaspal S., Körner, Antje, Kovacs, Peter, Kuh, Diana, Kumari, Meena, Kutalik, Zoltan, Laakso, Markku, Lakka, Timo A., Launer, Lenore J., Leander, Karin, Li, Huaixing, Lin, Xu, Lind, Lars, Lindgren, Cecilia, Liu, Simin, Loos, Ruth J F, Magnusson, Patrik K E, Mahajan, Anubha, Metspalu, Andres, Mook-Kanamori, Dennis O., Mori, Trevor A., Munroe, Patricia B., Njølstad, Inger, O'Connell, Jeffrey R., Oldehinkel, Albertine J., Ong, Ken K., Padmanabhan, Sandosh, Palmer, Colin N A, Palmer, Nicholette D., Pedersen, Oluf, Pennell, Craig E., Porteous, David J., Pramstaller, Peter P., Province, Michael A., Psaty, Bruce M., Qi, Lu, Raffel, Leslie J., Rauramaa, Rainer, Redline, Susan, Ridker, Paul M., Rosendaal, Frits R., Saaristo, Timo E., Sandhu, Manjinder, Saramies, Jouko, Schneiderman, Neil, Schwarz, Peter, Scott, Laura J., Selvin, Elizabeth, Sever, Peter, Shu, Xiao-Ou, Slagboom, P Eline, Small, Kerrin S., Smith, Blair H., Snieder, Harold, Sofer, Tamar, Sørensen, Thorkild I A, Spector, Tim D., Stanton, Alice, Steves, Claire J., Stumvoll, Michael, Sun, Liang, Tabara, Yasuharu, Tai, E Shyong, Timpson, Nicholas J., Tönjes, Anke, Tuomilehto, Jaakko, Tusie, Teresa, Uusitupa, Matti, van der Harst, Pim, van Duijn, Cornelia, Vitart, Veronique, Vollenweider, Peter, Vrijkotte, Tanja G M, Wagenknecht, Lynne E., Walker, Mark, Wang, Ya X., Wareham, Nick J., Watanabe, Richard M., Watkins, Hugh, Wei, Wen B., Wickremasinghe, Ananda R., Willemsen, Gonneke, Wilson, James F., Wong, Tien-Yin, Wu, Jer-Yuarn, Xiang, Anny H., Yanek, Lisa R., Yengo, Loïc, Yokota, Mitsuhiro, Zeggini, Eleftheria, Zheng, Wei, Zonderman, Alan B., Rotter, Jerome I., Gloyn, Anna L., McCarthy, Mark I., Dupuis, Josée, Meigs, James B., Scott, Robert A., Prokopenko, Inga, Leong, Aaron, Liu, Ching-Ti, Parker, Stephen C J, Mohlke, Karen L., Langenberg, Claudia, Wheeler, Eleanor, Morris, Andrew P., Barroso, Inês, Chen, Ji, Spracklen, Cassandra N., Marenne, Gaëlle, Varshney, Arushi, Corbin, Laura J., Luan, Jian'an, Willems, Sara M., Wu, Ying, Zhang, Xiaoshuai, Horikoshi, Momoko, Boutin, Thibaud S., Mägi, Reedik, Waage, Johannes, Li-Gao, Ruifang, Chan, Kei Hang Katie, Yao, Jie, Anasanti, Mila D., Chu, Audrey Y., Claringbould, Annique, Heikkinen, Jani, Hong, Jaeyoung, Hottenga, Jouke-Jan, Huo, Shaofeng, Kaakinen, Marika A., Louie, Tin, März, Winfried, Moreno-Macias, Hortensia, Ndungu, Anne, Nelson, Sarah C., Nolte, Ilja M., North, Kari E., Raulerson, Chelsea K., Ray, Debashree, Rohde, Rebecca, Rybin, Denis, Schurmann, Claudia, Sim, Xueling, Southam, Lorraine, Stewart, Isobel D., Wang, Carol A., Wang, Yujie, Wu, Peitao, Zhang, Weihua, Ahluwalia, Tarunveer S., Appel, Emil V R, Bielak, Lawrence F., Brody, Jennifer A., Burtt, Noël P, Cabrera, Claudia P., Cade, Brian E., Chai, Jin Fang, Chai, Xiaoran, Chang, Li-Ching, Chen, Chien-Hsiun, Chen, Brian H., Chitrala, Kumaraswamy Naidu, Chiu, Yen-Feng, de Haan, Hugoline G., Delgado, Graciela E., Demirkan, Ayse, Duan, Qing, Engmann, Jorgen, Fatumo, Segun A., Gayán, Javier, Giulianini, Franco, Gong, Jung Ho, Gustafsson, Stefan, Hai, Yang, Hartwig, Fernando P., He, Jing, Heianza, Yoriko, Huang, Tao, Huerta-Chagoya, Alicia, Hwang, Mi Yeong, Jensen, Richard A., Kawaguchi, Takahisa, Kentistou, Katherine A., Kim, Young Jin, Kleber, Marcus E., Kooner, Ishminder K., Lai, Shuiqing, Lange, Leslie A., Langefeld, Carl D., Lauzon, Marie, Li, Man, Ligthart, Symen, Liu, Jun, Loh, Marie, Long, Jirong, Lyssenko, Valeriya, Mangino, Massimo, Marzi, Carola, Montasser, May E., Nag, Abhishek, Nakatochi, Masahiro, Noce, Damia, Noordam, Raymond, Pistis, Giorgio, Preuss, Michael, Raffield, Laura, Rasmussen-Torvik, Laura J., Rich, Stephen S., Robertson, Neil R., Rueedi, Rico, Ryan, Kathleen, Sanna, Serena, Saxena, Richa, Schraut, Katharina E., Sennblad, Bengt, Setoh, Kazuya, Smith, Albert V., Sparsø, Thomas, Strawbridge, Rona J., Takeuchi, Fumihiko, Tan, Jingyi, Trompet, Stella, van den Akker, Erik, van der Most, Peter J., Verweij, Niek, Vogel, Mandy, Wang, Heming, Wang, Chaolong, Wang, Nan, Warren, Helen R., Wen, Wanqing, Wilsgaard, Tom, Wong, Andrew, Wood, Andrew R., Xie, Tian, Zafarmand, Mohammad Hadi, Zhao, Jing-Hua, Zhao, Wei, Amin, Najaf, Arzumanyan, Zorayr, Astrup, Arne, Bakker, Stephan J L, Baldassarre, Damiano, Beekman, Marian, Bergman, Richard N., Bertoni, Alain, Blüher, Matthias, Bonnycastle, Lori L., Bornstein, Stefan R., Bowden, Donald W., Cai, Qiuyin, Campbell, Archie, Campbell, Harry, Chang, Yi Cheng, de Geus, Eco J C, Dehghan, Abbas, Du, Shufa, Eiriksdottir, Gudny, Farmaki, Aliki Eleni, Frånberg, Mattias, Fuchsberger, Christian, Gao, Yutang, Gjesing, Anette P., Goel, Anuj, Han, Sohee, Hartman, Catharina A., Herder, Christian, Hicks, Andrew A., Hsieh, Chang-Hsun, Hsueh, Willa A., Ichihara, Sahoko, Igase, Michiya, Ikram, M Arfan, Johnson, W Craig, Jørgensen, Marit E., Joshi, Peter K., Kalyani, Rita R., Kandeel, Fouad R., Katsuya, Tomohiro, Khor, Chiea Chuen, Kiess, Wieland, Kolcic, Ivana, Kuulasmaa, Teemu, Kuusisto, Johanna, Läll, Kristi, Lam, Kelvin, Lawlor, Deborah A., Lee, Nanette R., Lemaitre, Rozenn N., Li, Honglan, Lin, Shih-Yi, Lindström, Jaana, Linneberg, Allan, Liu, Jianjun, Lorenzo, Carlos, Matsubara, Tatsuaki, Matsuda, Fumihiko, Mingrone, Geltrude, Mooijaart, Simon, Moon, Sanghoon, Nabika, Toru, Nadkarni, Girish N., Nadler, Jerry L., Nelis, Mari, Neville, Matt J., Norris, Jill M., Ohyagi, Yasumasa, Peters, Annette, Peyser, Patricia A., Polasek, Ozren, Qi, Qibin, Raven, Dennis, Reilly, Dermot F., Reiner, Alex, Rivideneira, Fernando, Roll, Kathryn, Rudan, Igor, Sabanayagam, Charumathi, Sandow, Kevin, Sattar, Naveed, Schürmann, Annette, Shi, Jinxiu, Stringham, Heather M., Taylor, Kent D., Teslovich, Tanya M., Thuesen, Betina, Timmers, Paul R H J, Tremoli, Elena, Tsai, Michael Y., Uitterlinden, Andre, van Dam, Rob M., van Heemst, Diana, van Hylckama Vlieg, Astrid, van Vliet-Ostaptchouk, Jana V., Vangipurapu, Jagadish, Vestergaard, Henrik, Wang, Tao, Willems van Dijk, Ko, Zemunik, Tatijana, Abecasis, Gonçalo R, Adair, Linda S., Aguilar-Salinas, Carlos Alberto, Alarcón-Riquelme, Marta E., An, Ping, Aviles-Santa, Larissa, Becker, Diane M., Beilin, Lawrence J., Bergmann, Sven, Bisgaard, Hans, Black, Corri, Boehnke, Michael, Boerwinkle, Eric, Böhm, Bernhard O., Bønnelykke, Klaus, Boomsma, D.I., Bottinger, Erwin P., Buchanan, Thomas A., Canouil, Mickaël, Caulfield, Mark J., Chambers, John C., Chasman, Daniel I., Chen, Yii-Der Ida, Cheng, Ching-Yu, Collins, Francis S., Correa, Adolfo, Cucca, Francesco, de Silva, H Janaka, Dedoussis, George, Elmståhl, Sölve, Evans, Michele K., Ferrannini, Ele, Ferrucci, Luigi, Florez, Jose C., Franks, Paul W., Frayling, Timothy M., Froguel, Philippe, Gigante, Bruna, Goodarzi, Mark O., Gordon-Larsen, Penny, Grallert, Harald, Grarup, Niels, Grimsgaard, Sameline, Groop, Leif, Gudnason, Vilmundur, Guo, Xiuqing, Hamsten, Anders, Hansen, Torben, Hayward, Caroline, Heckbert, Susan R., Horta, Bernardo L., Huang, Wei, Ingelsson, Erik, James, Pankow S., Jarvelin, Marjo-Ritta, Jonas, Jost B., Jukema, J Wouter, Kaleebu, Pontiano, Kaplan, Robert, Kardia, Sharon L R, Kato, Norihiro, Keinanen-Kiukaanniemi, Sirkka M., Kim, Bong-Jo, Kivimaki, Mika, Koistinen, Heikki A., Kooner, Jaspal S., Körner, Antje, Kovacs, Peter, Kuh, Diana, Kumari, Meena, Kutalik, Zoltan, Laakso, Markku, Lakka, Timo A., Launer, Lenore J., Leander, Karin, Li, Huaixing, Lin, Xu, Lind, Lars, Lindgren, Cecilia, Liu, Simin, Loos, Ruth J F, Magnusson, Patrik K E, Mahajan, Anubha, Metspalu, Andres, Mook-Kanamori, Dennis O., Mori, Trevor A., Munroe, Patricia B., Njølstad, Inger, O'Connell, Jeffrey R., Oldehinkel, Albertine J., Ong, Ken K., Padmanabhan, Sandosh, Palmer, Colin N A, Palmer, Nicholette D., Pedersen, Oluf, Pennell, Craig E., Porteous, David J., Pramstaller, Peter P., Province, Michael A., Psaty, Bruce M., Qi, Lu, Raffel, Leslie J., Rauramaa, Rainer, Redline, Susan, Ridker, Paul M., Rosendaal, Frits R., Saaristo, Timo E., Sandhu, Manjinder, Saramies, Jouko, Schneiderman, Neil, Schwarz, Peter, Scott, Laura J., Selvin, Elizabeth, Sever, Peter, Shu, Xiao-Ou, Slagboom, P Eline, Small, Kerrin S., Smith, Blair H., Snieder, Harold, Sofer, Tamar, Sørensen, Thorkild I A, Spector, Tim D., Stanton, Alice, Steves, Claire J., Stumvoll, Michael, Sun, Liang, Tabara, Yasuharu, Tai, E Shyong, Timpson, Nicholas J., Tönjes, Anke, Tuomilehto, Jaakko, Tusie, Teresa, Uusitupa, Matti, van der Harst, Pim, van Duijn, Cornelia, Vitart, Veronique, Vollenweider, Peter, Vrijkotte, Tanja G M, Wagenknecht, Lynne E., Walker, Mark, Wang, Ya X., Wareham, Nick J., Watanabe, Richard M., Watkins, Hugh, Wei, Wen B., Wickremasinghe, Ananda R., Willemsen, Gonneke, Wilson, James F., Wong, Tien-Yin, Wu, Jer-Yuarn, Xiang, Anny H., Yanek, Lisa R., Yengo, Loïc, Yokota, Mitsuhiro, Zeggini, Eleftheria, Zheng, Wei, Zonderman, Alan B., Rotter, Jerome I., Gloyn, Anna L., McCarthy, Mark I., Dupuis, Josée, Meigs, James B., Scott, Robert A., Prokopenko, Inga, Leong, Aaron, Liu, Ching-Ti, Parker, Stephen C J, Mohlke, Karen L., Langenberg, Claudia, Wheeler, Eleanor, Morris, Andrew P., and Barroso, Inês

Abstract

Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P < 5 × 10-8), 80% of which had no significant evidence of between-ancestry heterogeneity. Analyses restricted to individuals of European ancestry with equivalent sample size would have led to 24 fewer new loci. Compared with single-ancestry analyses, equivalent-sized trans-ancestry fine-mapping reduced the number of estimated variants in 99% credible sets by a median of 37.5%. Genomic-feature, gene-expression and gene-set analyses revealed distinct biological signatures for each trait, highlighting different underlying biological pathways. Our results increase our understanding of diabetes pathophysiology by using trans-ancestry studies for improved power and resolution.

Published
2021
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17. Associations of Sleep-disordered Breathing and Insomnia with Incident Hypertension and Diabetes. The Hispanic Community Health Study/Study of Latinos

Author

Li, Xiaoyu, primary, Sotres-Alvarez, Daniela, additional, Gallo, Linda C., additional, Ramos, Alberto R., additional, Aviles-Santa, Larissa, additional, Perreira, Krista M., additional, Isasi, Carmen R., additional, Zee, Phyllis C., additional, Savin, Kimberly L., additional, Schneiderman, Neil, additional, Wassertheil-Smoller, Sylvia, additional, Sofer, Tamar, additional, Daviglus, Martha, additional, and Redline, Susan, additional

Published
2021
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18. SMIM1absence is associated with reduced energy expenditure and excess weight

Author

Stefanucci, Luca, Moslemi, Camous, Tomé, Ana R., Virtue, Samuel, Bidault, Guillaume, Gleadall, Nicholas S., Watson, Laura P.E., Kwa, Jing E., Burden, Frances, Farrow, Samantha, Banasik, Karina, Bay, Jakob, Boldsen, Jens Kjærgaard, Brodersen, Thorsten, Brunak, Søren, Burgdorf, Kristoffer, Chalmer, Mona Ameri, Didriksen, Maria, Dinh, Khoa Manh, Dowsett, Joseph, Erikstrup, Christian, Feenstra, Bjarke, Geller, Frank, Gudbjartsson, Daniel, Hansen, Thomas Folkmann, Hindhede, Lotte, Hjalgrim, Henrik, Jacobsen, Rikke Louise, Jemec, Gregor, Jensen, Bitten Aagaard, Kaspersen, Katrine, Kjerulff, Bertram Dalskov, Kogelman, Lisette, Hørup Larsen, Margit Anita, Louloudis, Ioannis, Lundgaard, Agnete, Susan, Mikkelsen, Christina, Nissen, Ioanna, Nyegaard, Mette, Ostrowski, Sisse Rye, Pedersen, Ole Birger, Henriksen, Alexander Pil, Rohde, Palle Duun, Rostgaard, Klaus, Schwinn, Michael, Stefansson, Kari, Stefánsson, Hreinn, Sørensen, Erik, þorsteinsdóttir, Unnur, Thørner, Lise Wegner, Bruun, Mie Topholm, Ullum, Henrik, Werge, Thomas, Westergaard, David, Chen, Ji, Chen, Ji, Spracklen, Cassandra N., Marenne, Gaëlle, Varshney, Arushi, Corbin, Laura J., Luan, Jian’an, Willems, Sara M., Wu, Ying, Zhang, Xiaoshuai, Horikoshi, Momoko, Boutin, Thibaud S., Mägi, Reedik, Waage, Johannes, Li-Gao, Ruifang, Katie Chan, Kei Hang, Yao, Jie, Anasanti, Mila D., Chu, Audrey Y., Claringbould, Annique, Heikkinen, Jani, Hong, Jaeyoung, Hottenga, Jouke-Jan, Huo, Shaofeng, Kaakinen, Marika A., Louie, Tin, März, Winfried, Moreno-Macias, Hortensia, Ndungu, Anne, Nelson, Sarah C., Nolte, Ilja M., North, Kari E., Raulerson, Chelsea K., Ray, Debashree, Rohde, Rebecca, Rybin, Denis, Schurmann, Claudia, Sim, Xueling, Southam, Loz, Stewart, Isobel D., Wang, Carol A., Wang, Yujie, Wu, Peitao, Zhang, Weihua, Ahluwalia, Tarunveer S., Appel, Emil V.R., Bielak, Lawrence F., Brody, Jennifer A., Burtt, Noël P., Cabrera, Claudia P., Cade, Brian E., Chai, Jin Fang, Chai, Xiaoran, Chang, Li-Ching, Chen, Chien-Hsiun, Chen, Brian H., Chitrala, Kumaraswamy Naidu, Chiu, Yen-Feng, de Haan, Hugoline G., Delgado, Graciela E., Demirkan, Ayse, Duan, Qing, Engmann, Jorgen, Fatumo, Segun A., Gayán, Javier, Giulianini, Franco, Gong, Jung Ho, Gustafsson, Stefan, Hai, Yang, Hartwig, Fernando P., He, Jing, Heianza, Yoriko, Huang, Tao, Huerta-Chagoya, Alicia, Hwang, Mi Yeong, Jensen, Richard A., Kawaguchi, Takahisa, Kentistou, Katherine A., Kim, Young Jin, Kleber, Marcus E., Kooner, Ishminder K., Lai, Shuiqing, Lange, Leslie A., Langefeld, Carl D., Lauzon, Marie, Li, Man, Ligthart, Symen, Liu, Jun, Loh, Marie, Long, Jirong, Lyssenko, Valeriya, Mangino, Massimo, Marzi, Carola, Montasser, May E., Nag, Abhishek, Nakatochi, Masahiro, Noce, Damia, Noordam, Raymond, Pistis, Giorgio, Preuss, Michael, Raffield, Laura, Rasmussen-Torvik, Laura J., Rich, Stephen S., Robertson, Neil R., Rueedi, Rico, Ryan, Kathleen, Sanna, Serena, Saxena, Richa, Schraut, Katharina E., Sennblad, Bengt, Setoh, Kazuya, Smith, Albert V., Southam, Lorraine, Sparsø, Thomas, Strawbridge, Rona J., Takeuchi, Fumihiko, Tan, Jingyi, Trompet, Stella, van den Akker, Erik, van der Most, Peter J., Verweij, Niek, Vogel, Mandy, Wang, Heming, Wang, Chaolong, Wang, Nan, Warren, Helen R., Wen, Wanqing, Wilsgaard, Tom, Wong, Andrew, Wood, Andrew R., Xie, Tian, Zafarmand, Mohammad Hadi, Zhao, Jing-Hua, Zhao, Wei, Amin, Najaf, Arzumanyan, Zorayr, Astrup, Arne, Bakker, Stephan J.L., Baldassarre, Damiano, Beekman, Marian, Bergman, Richard N., Bertoni, Alain, Blüher, Matthias, Bonnycastle, Lori L., Bornstein, Stefan R., Bowden, Donald W., Cai, Qiuyin, Campbell, Archie, Campbell, Harry, Chang, Yi Cheng, de Geus, Eco J.C., Dehghan, Abbas, Du, Shufa, Eiriksdottir, Gudny, Farmaki, Aliki Eleni, Frånberg, Mattias, Fuchsberger, Christian, Gao, Yutang, Gjesing, Anette P., Goel, Anuj, Han, Sohee, Hartman, Catharina A., Herder, Christian, Hicks, Andrew A., Hsieh, Chang-Hsun, Hsueh, Willa A., Ichihara, Sahoko, Igase, Michiya, Ikram, M. Arfan, Johnson, W. Craig, Jørgensen, Marit E., Joshi, Peter K., Kalyani, Rita R., Kandeel, Fouad R., Katsuya, Tomohiro, Khor, Chiea Chuen, Kiess, Wieland, Kolcic, Ivana, Kuulasmaa, Teemu, Kuusisto, Johanna, Läll, Kristi, Lam, Kelvin, Lawlor, Deborah A., Lee, Nanette R., Lemaitre, Rozenn N., Li, Honglan, Lin, Shih-Yi, Lindström, Jaana, Linneberg, Allan, Liu, Jianjun, Lorenzo, Carlos, Matsubara, Tatsuaki, Matsuda, Fumihiko, Mingrone, Geltrude, Mooijaart, Simon, Moon, Sanghoon, Nabika, Toru, Nadkarni, Girish N., Nadler, Jerry L., Nelis, Mari, Neville, Matt J., Norris, Jill M., Ohyagi, Yasumasa, Peters, Annette, Peyser, Patricia A., Polasek, Ozren, Qi, Qibin, Raven, Dennis, Reilly, Dermot F., Reiner, Alex, Rivideneira, Fernando, Roll, Kathryn, Rudan, Igor, Sabanayagam, Charumathi, Sandow, Kevin, Sattar, Naveed, Schürmann, Annette, Shi, Jinxiu, Stringham, Heather M., Taylor, Kent D., Teslovich, Tanya M., Thuesen, Betina, Timmers, Paul R.H.J., Tremoli, Elena, Tsai, Michael Y., Uitterlinden, Andre, van Dam, Rob M., van Heemst, Diana, van Hylckama Vlieg, Astrid, Van Vliet-Ostaptchouk, Jana V., Vangipurapu, Jagadish, Vestergaard, Henrik, Wang, Tao, Willems van Dijk, Ko, Zemunik, Tatijana, Abecasis, Goncalo R., Adair, Linda S., Aguilar-Salinas, Carlos Alberto, Alarcón-Riquelme, Marta E., An, Ping, Aviles-Santa, Larissa, Becker, Diane M., Beilin, Lawrence J., Bergmann, Sven, Bisgaard, Hans, Black, Corri, Boehnke, Michael, Boerwinkle, Eric, Böhm, Bernhard O., Bønnelykke, Klaus, Boomsma, D.I., Bottinger, Erwin P., Buchanan, Thomas A., Canouil, Mickaël, Caulfield, Mark J., Chambers, John C., Chasman, Daniel I., Ida Chen, Yii-Der, Cheng, Ching-Yu, Collins, Francis S., Correa, Adolfo, Cucca, Francesco, Janaka de Silva, H., Dedoussis, George, Elmståhl, Sölve, Evans, Michele K., Ferrannini, Ele, Ferrucci, Luigi, Florez, Jose C., Franks, Paul W., Frayling, Timothy M., Froguel, Philippe, Gigante, Bruna, Goodarzi, Mark O., Gordon-Larsen, Penny, Grallert, Harald, Grarup, Niels, Grimsgaard, Sameline, Groop, Leif, Gudnason, Vilmundur, Guo, Xiuqing, Hamsten, Anders, Hansen, Torben, Hayward, Caroline, Heckbert, Susan R., Horta, Bernardo L., Huang, Wei, Ingelsson, Erik, James, Pankow S., Jarvelin, Marjo-Ritta, Jonas, Jost B., Jukema, J. Wouter, Kaleebu, Pontiano, Kaplan, Robert, Kardia, Sharon L.R., Kato, Norihiro, Keinanen-Kiukaanniemi, Sirkka M., Kim, Bong-Jo, Kivimaki, Mika, Koistinen, Heikki A., Kooner, Jaspal S., Körner, Antje, Kovacs, Peter, Kuh, Diana, Kumari, Meena, Kutalik, Zoltan, Laakso, Markku, Lakka, Timo A., Launer, Lenore J., Leander, Karin, Li, Huaixing, Lin, Xu, Lind, Lars, Lindgren, Cecilia, Liu, Simin, Loos, Ruth J.F., Magnusson, Patrik K.E., Mahajan, Anubha, Metspalu, Andres, Mook-Kanamori, Dennis O., Mori, Trevor A., Munroe, Patricia B., Njølstad, Inger, O'Connell, Jeffrey R., Oldehinkel, Albertine J., Ong, Ken K., Padmanabhan, Sandosh, Palmer, Colin N.A., Palmer, Nicholette D., Pedersen, Oluf, Pennell, Craig E., Porteous, David J., Pramstaller, Peter P., Province, Michael A., Psaty, Bruce M., Qi, Lu, Raffel, Leslie J., Rauramaa, Rainer, Redline, Susan, Ridker, Paul M., Rosendaal, Frits R., Saaristo, Timo E., Sandhu, Manjinder, Saramies, Jouko, Schneiderman, Neil, Schwarz, Peter, Scott, Laura J., Selvin, Elizabeth, Sever, Peter, Shu, Xiao-Ou, Slagboom, P. Eline, Small, Kerrin S., Smith, Blair H., Snieder, Harold, Sofer, Tamar, Sørensen, Thorkild I.A., Spector, Tim D., Stanton, Alice, Steves, Claire J., Stumvoll, Michael, Sun, Liang, Tabara, Yasuharu, Tai, E. Shyong, Timpson, Nicholas J., Tönjes, Anke, Tuomilehto, Jaakko, Tusie, Teresa, Uusitupa, Matti, van der Harst, Pim, van Duijn, Cornelia, Vitart, Veronique, Vollenweider, Peter, Vrijkotte, Tanja G.M., Wagenknecht, Lynne E., Walker, Mark, Wang, Ya X., Wareham, Nick J., Watanabe, Richard M., Watkins, Hugh, Wei, Wen B., Wickremasinghe, Ananda R., Willemsen, Gonneke, Wilson, James F., Wong, Tien-Yin, Wu, Jer-Yuarn, Xiang, Anny H., Yanek, Lisa R., Yengo, Loïc, Yokota, Mitsuhiro, Zeggini, Eleftheria, Zheng, Wei, Zonderman, Alan B., Rotter, Jerome I., Gloyn, Anna L., McCarthy, Mark I., Dupuis, Josée, Meigs, James B., Scott, Robert A., Prokopenko, Inga, Leong, Aaron, Liu, Ching-Ti, Parker, Stephen C.J., Mohlke, Karen L., Langenberg, Claudia, Wheeler, Eleanor, Morris, Andrew P., Barroso, Inês, Võsa, Urmo, Burling, Keith, Walker, Lindsay, Ord, John, Barker, Peter, Warner, James, Frary, Amy, Renhstrom, Karola, Ashford, Sofie E., Piper, Jo, Biggs, Gail, Erber, Wendy N., Hoffman, Gary J., Schoenmakers, Nadia, Erikstrup, Christian, Rieneck, Klaus, Dziegiel, Morten H., Ullum, Henrik, Azzu, Vian, Vacca, Michele, Aparicio, Hugo Javier, Hui, Qin, Cho, Kelly, Sun, Yan V., Wilson, Peter W., Bayraktar, Omer A., Vidal-Puig, Antonio, Ostrowski, Sisse R., Astle, William J., Olsson, Martin L., Storry, Jill R., Pedersen, Ole B., Ouwehand, Willem H., Chatterjee, Krishna, Vuckovic, Dragana, and Frontini, Mattia

Abstract

Obesity rates have nearly tripled in the past 50 years, and by 2030 more than 1 billion individuals worldwide are projected to be obese. This creates a significant economic strain due to the associated non-communicable diseases. The root cause is an energy expenditure imbalance, owing to an interplay of lifestyle, environmental, and genetic factors. Obesity has a polygenic genetic architecture; however, single genetic variants with large effect size are etiological in a minority of cases. These variants allowed the discovery of novel genes and biology relevant to weight regulation and ultimately led to the development of novel specific treatments.

Published
2024
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21. The Trans-Ancestral Genomic Architecture of Glycaemic Traits

Author

Chen, Ji, primary, Spracklen, Cassandra N., additional, Marenne, Gaëlle, additional, Varshney, Arushi, additional, Corbin, Laura J, additional, Luan, Jian’an, additional, Willems, Sara, additional, Wu, Ying, additional, Zhang, Xiaoshuai, additional, Horikoshi, Momoko, additional, Boutin, Thibaud S, additional, Mägi, Reedik, additional, Waage, Johannes, additional, Pitsilides, Achilleas, additional, Li-Gao, Ruifang, additional, Hang, Kei, additional, Yao, Jie, additional, Anasanti, Mila D, additional, Chu, Audrey Y, additional, Claringbould, Annique, additional, Heikkinen, Jani, additional, Hong, Jaeyoung, additional, Hottenga, Jouke-Jan, additional, Huo, Shaofeng, additional, Kaakinen, Marika A., additional, Louie, Tin, additional, März, Winfried, additional, Moreno-Macias, Hortensia, additional, Ndungu, Anne, additional, Nelson, Sarah C., additional, Nolte, Ilja M., additional, North, Kari, additional, Raulerson, Chelsea K., additional, Ray, Debashree, additional, Rohde, Rebecca, additional, Rybin, Denis, additional, Schurmann, Claudia, additional, Sim, Xueling, additional, Southam, Loz, additional, Stewart, Isobel, additional, Wang, Carol A., additional, Wang, Yujie, additional, Wu, Peitao, additional, Zhang, Weihua, additional, Ahluwalia, Tarunveer S., additional, Appel, Emil VR, additional, Bielak, Lawrence F., additional, Brody, Jennifer A., additional, Burtt, Noel P, additional, Cabrera, Claudia P, additional, Cade, Brian E, additional, Chai, Jin Fang, additional, Chai, Xiaoran, additional, Chang, Li-Ching, additional, Chen, Chien-Hsiun, additional, Chen, Brian H, additional, Chitrala, Kumaraswamy N, additional, Chiu, Yen-Feng, additional, de Haan, Hugoline G., additional, Delgado, Graciela E, additional, Demirkan, Ayse, additional, Duan, Qing, additional, Engmann, Jorgen, additional, Fatumo, Segun A, additional, Gayán, Javier, additional, Giulianini, Franco, additional, Gong, Jung Ho, additional, Gustafsson, Stefan, additional, Hai, Yang, additional, Hartwig, Fernando P, additional, He, Jing, additional, Heianza, Yoriko, additional, Huang, Tao, additional, Huerta-Chagoya, Alicia, additional, Hwang, Mi Yeong, additional, Jensen, Richard A., additional, Kawaguchi, Takahisa, additional, Kentistou, Katherine A, additional, Kim, Young Jin, additional, Kleber, Marcus E, additional, Kooner, Ishminder K, additional, Lai, Shuiqing, additional, Lange, Leslie A, additional, Langefeld, Carl D, additional, Lauzon, Marie, additional, Li, Man, additional, Ligthart, Symen, additional, Liu, Jun, additional, Loh, Marie, additional, Long, Jirong, additional, Lyssenko, Valeriya, additional, Mangino, Massimo, additional, Marzi, Carola, additional, Montasser, May E, additional, Nag, Abhishek, additional, Nakatochi, Masahiro, additional, Noce, Damia, additional, Noordam, Raymond, additional, Pistis, Giorgio, additional, Preuss, Michael, additional, Raffield, Laura, additional, Rasmussen-Torvik, Laura J., additional, Rich, Stephen S, additional, Robertson, Neil R, additional, Rueedi, Rico, additional, Ryan, Kathleen, additional, Sanna, Serena, additional, Saxena, Richa, additional, Schraut, Katharina E, additional, Sennblad, Bengt, additional, Setoh, Kazuya, additional, Smith, Albert V, additional, Southam, Lorraine, additional, Sparsø, Thomas, additional, Strawbridge, Rona J, additional, Takeuchi, Fumihiko, additional, Tan, Jingyi, additional, Trompet, Stella, additional, van den Akker, Erik, additional, Van der Most, Peter J, additional, Verweij, Niek, additional, Vogel, Mandy, additional, Wang, Heming, additional, Wang, Chaolong, additional, Wang, Nan, additional, Warren, Helen R, additional, Wen, Wanqing, additional, Wilsgaard, Tom, additional, Wong, Andrew, additional, Wood, Andrew R, additional, Xie, Tian, additional, Zafarmand, Mohammad Hadi, additional, Zhao, Jing-Hua, additional, Zhao, Wei, additional, Amin, Najaf, additional, Arzumanyan, Zorayr, additional, Astrup, Arne, additional, Bakker, Stephan JL, additional, Baldassarre, Damiano, additional, Beekman, Marian, additional, Bergman, Richard N, additional, Bertoni, Alain, additional, Blüher, Matthias, additional, Bonnycastle, Lori L., additional, Bornstein, Stefan R, additional, Bowden, Donald W, additional, Cai, Qiuyin, additional, Campbell, Archie, additional, Campbell, Harry, additional, Chang, Yi Cheng, additional, de Geus, Eco J.C., additional, Dehghan, Abbas, additional, Du, Shufa, additional, Eiriksdottir, Gudny, additional, Farmaki, Aliki Eleni, additional, Frånberg, Mattias, additional, Fuchsberger, Christian, additional, Gao, Yutang, additional, Gjesing, Anette P, additional, Goel, Anuj, additional, Han, Sohee, additional, Hartman, Catharina A, additional, Herder, Christian, additional, Hicks, Andrew A., additional, Hsieh, Chang-Hsun, additional, Hsueh, Willa A., additional, Ichihara, Sahoko, additional, Igase, Michiya, additional, Ikram, M. Arfan, additional, Johnson, W. Craig, additional, Jørgensen, Marit E, additional, Joshi, Peter K, additional, Kalyani, Rita R, additional, Kandeel, Fouad R., additional, Katsuya, Tomohiro, additional, Khor, Chiea Chuen, additional, Kiess, Wieland, additional, Kolcic, Ivana, additional, Kuulasmaa, Teemu, additional, Kuusisto, Johanna, additional, Läll, Kristi, additional, Lam, Kelvin, additional, Lawlor, Deborah A, additional, Lee, Nanette R., additional, Lemaitre, Rozenn N., additional, Li, Honglan, additional, Study, Lifelines Cohort, additional, Lin, Shih-Yi, additional, Lindström, Jaana, additional, Linneberg, Allan, additional, Liu, Jianjun, additional, Lorenzo, Carlos, additional, Matsubara, Tatsuaki, additional, Matsuda, Fumihiko, additional, Mingrone, Geltrude, additional, Mooijaart, Simon, additional, Moon, Sanghoon, additional, Nabika, Toru, additional, Nadkarni, Girish N., additional, Nadler, Jerry L., additional, Nelis, Mari, additional, Neville, Matthew J, additional, Norris, Jill M, additional, Ohyagi, Yasumasa, additional, Peters, Annette, additional, Peyser, Patricia A., additional, Polasek, Ozren, additional, Qi, Qibin, additional, Raven, Dennis, additional, Reilly, Dermot F, additional, Reiner, Alex, additional, Rivideneira, Fernando, additional, Roll, Kathryn, additional, Rudan, Igor, additional, Sabanayagam, Charumathi, additional, Sandow, Kevin, additional, Sattar, Naveed, additional, Schürmann, Annette, additional, Shi, Jinxiu, additional, Stringham, Heather M, additional, Taylor, Kent D., additional, Teslovich, Tanya M., additional, Thuesen, Betina, additional, Timmers, Paul RHJ, additional, Tremoli, Elena, additional, Tsai, Michael Y, additional, Uitterlinden, Andre, additional, van Dam, Rob M, additional, van Heemst, Diana, additional, van Hylckama Vlieg, Astrid, additional, Van Vliet-Ostaptchouk, Jana V, additional, Vangipurapu, Jagadish, additional, Vestergaard, Henrik, additional, Wang, Tao, additional, van Dijk, Ko Willems, additional, Xiang, Yongbing, additional, Zemunik, Tatijana, additional, Abecasis, Goncalo R, additional, Adair, Linda S., additional, Aguilar-Salinas, Carlos Alberto, additional, Alarcón-Riquelme, Marta E, additional, An, Ping, additional, Aviles-Santa, Larissa, additional, Becker, Diane M, additional, Beilin, Lawrence J, additional, Bergmann, Sven, additional, Bisgaard, Hans, additional, Black, Corri, additional, Boehnke, Michael, additional, Boerwinkle, Eric, additional, Böhm, Bernhard O, additional, Bønnelykke, Klaus, additional, Boomsma, D I., additional, Bottinger, Erwin P., additional, Buchanan, Thomas A, additional, Canouil, Mickaël, additional, Caulfield, Mark J, additional, Chambers, John C., additional, Chasman, Daniel I., additional, Chen, Yii-Der Ida, additional, Cheng, Ching-Yu, additional, Collins, Francis S., additional, Correa, Adolfo, additional, Cucca, Francesco, additional, de Silva, H. Janaka, additional, Dedoussis, George, additional, Elmståhl, Sölve, additional, Evans, Michele K., additional, Ferranni, Ele, additional, Ferruci, Luigi, additional, Florez, Jose C, additional, Franks, Paul, additional, Frayling, Timothy M, additional, Froguel, Philippe, additional, Gigante, Bruna, additional, Goodarzi, Mark O., additional, Gordon-Larsen, Penny, additional, Grallert, Harald, additional, Grarup, Niels, additional, Grimsgaard, Sameline, additional, Groop, Leif, additional, Gudnason, Vilmundur, additional, Guo, Xiuqing, additional, Hamsten, Anders, additional, Hansen, Torben, additional, Hayward, Caroline, additional, Heckbert, Susan R., additional, Horta, Bernardo L, additional, Huang, Wei, additional, Ingelsson, Erik, additional, James, Pankow S, additional, Jonas, Jost B, additional, Jukema, J. Wouter, additional, Kaleebu, Pontiano, additional, Kaplan, Robert, additional, Kardia, Sharon L.R., additional, Kato, Norihiro, additional, Keinanen-Kiukaanniemi, Sirkka M., additional, Kim, Bong-Jo, additional, Kivimaki, Mika, additional, Koistinen, Heikki A., additional, Kooner, Jaspal S., additional, Körner, Antje, additional, Kovacs, Peter, additional, Kuh, Diana, additional, Kumari, Meena, additional, Kutalik, Zoltan, additional, Laakso, Markku, additional, Lakka, Timo A., additional, Launer, Lenore J, additional, Leander, Karin, additional, Li, Huaixing, additional, Lin, Xu, additional, Lind, Lars, additional, Lindgren, Cecilia, additional, Liu, Simin, additional, Loos, Ruth J.F., additional, Magnusson, Patrik, additional, Mahajan, Anubha, additional, Metspalu, Andres, additional, Mook-Kanamori, Dennis O, additional, Mori, Trevor A, additional, Munroe, Patricia B, additional, Njølstad, Inger, additional, O’Connell, Jeffrey R, additional, Oldehinkel, Albertine J, additional, Ong, Ken K, additional, Padmanabhan, Sandosh, additional, Palmer, Colin N.A., additional, Palmer, Nicholette D, additional, Pedersen, Oluf, additional, Pennell, Craig E, additional, Porteous, David J, additional, Pramstaller, Peter P., additional, Province, Michael A., additional, Psaty, Bruce M., additional, Qi, Lu, additional, Raffel, Leslie J., additional, Rauramaa, Rainer, additional, Redline, Susan, additional, Ridker, Paul M, additional, Rosendaal, Frits R., additional, Saaristo, Timo E., additional, Sandhu, Manjinder, additional, Saramies, Jouko, additional, Schneiderman, Neil, additional, Schwarz, Peter, additional, Scott, Laura J., additional, Selvin, Elizabeth, additional, Sever, Peter, additional, Shu, Xiao-ou, additional, Slagboom, P Eline, additional, Small, Kerrin S, additional, Smith, Blair H, additional, Snieder, Harold, additional, Sofer, Tamar, additional, Sørensen, Thorkild I.A., additional, Spector, Tim D, additional, Stanton, Alice, additional, Steves, Claire J, additional, Stumvoll, Michael, additional, Sun, Liang, additional, Tabara, Yasuharu, additional, Tai, E Shyong, additional, Timpson, Nicholas J, additional, Tönjes, Anke, additional, Tuomilehto, Jaakko, additional, Tusie, Teresa, additional, Uusitupa, Matti, additional, van der Harst, Pim, additional, van Duijn, Cornelia, additional, Vitart, Veronique, additional, Vollenweider, Peter, additional, Vrijkotte, Tanja GM, additional, Wagenknecht, Lynne E, additional, Walker, Mark, additional, Wang, Ya X, additional, Wareham, Nick J, additional, Watanabe, Richard M, additional, Watkins, Hugh, additional, Wei, Wen B, additional, Wickremasinghe, Ananda R, additional, Willemsen, Gonneke, additional, Wilson, James F, additional, Wong, Tien-Yin, additional, Wu, Jer-Yuarn, additional, Xiang, Anny H, additional, Yanek, Lisa R, additional, Yengo, Loïc, additional, Yokota, Mitsuhiro, additional, Zeggini, Eleftheria, additional, Zheng, Wei, additional, Zonderman, Alan B, additional, Rotter, Jerome I, additional, Gloyn, Anna L, additional, McCarthy, Mark I., additional, Dupuis, Josée, additional, Meigs, James B, additional, Scott, Robert, additional, Prokopenko, Inga, additional, Leong, Aaron, additional, Liu, Ching-Ti, additional, Parker, Stephen CJ, additional, Mohlke, Karen L., additional, Langenberg, Claudia, additional, Wheeler, Eleanor, additional, Morris, Andrew P., additional, and Barroso, Inês, additional

Published
2020
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22. Abstract P446: Hispanics/Latinos With Prediabetes are Eligible for Diabetes Prevention Intervention: Findings From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Author

Hutten Selkirk, Christina G, primary, Sanchez, Carlos, additional, Pirzada, Amber, additional, Wu, Donghong, additional, Aviles-Santa, Larissa, additional, Gallo, Linda, additional, Giachello, Aida L, additional, Kaplan, Robert, additional, Schneiderman, Neil, additional, Talavera, Gregory A, additional, Teng, Yanping, additional, Espinoza Giacinto, Rebeca A, additional, Moncrieft, Ashley E, additional, and Daviglus, Martha L, additional

Published
2020
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28. Factors associated with undiagnosed diabetes among adults with diabetes: Results from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Author

Casagrande, Sarah Stark, primary, Menke, Andy, additional, Aviles-Santa, Larissa, additional, Gallo, Linda C., additional, Daviglus, Martha L., additional, Talavera, Gregory A., additional, Castañeda, Sheila F., additional, Perreira, Krista, additional, Loop, Matthew Shane, additional, Tarraf, Wassim, additional, González, Hector M., additional, and Cowie, Catherine C., additional

Published
2018
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30. Associations of Sleep-disordered Breathing and Insomnia with Incident Hypertension and Diabetes. The Hispanic Community Health Study/Study of Latinos.

Author

Xiaoyu Li, Sotres-Alvarez, Daniela, Gallo, Linda C., Ramos, Alberto R., Aviles-Santa, Larissa, Perreira, Krista M., Isasi, Carmen R., Zee, Phyllis C., Savin, Kimberly L., Schneiderman, Neil, Wassertheil-Smoller, Sylvia, Sofer, Tamar, Daviglus, Martha, Redline, Susan, and Li, Xiaoyu

Subjects
SLEEP disorders, HYPERTENSION risk factors, DIABETES risk factors, CARDIOVASCULAR disease related mortality, HEALTH of Hispanic Americans
Abstract

Rationale: Sleep disorders are associated with hypertension and diabetes, which are primary risk factors for cardiovascular diseases and mortality. It is important to understand these associations in Hispanic/Latino individuals, in whom cardiovascular death is the leading cause of mortality.Objectives: To investigate the prospective associations of sleep-disordered breathing (SDB) and insomnia with incident hypertension and diabetes among U.S. Hispanic/Latino people over 6 years of follow-up and to assess potential sex differences in these associations.Methods: Data from 11,623 Hispanic/Latino participants in the Hispanic Community Health Study/Study of Latinos (visit 1, 2008-2011; visit 2, 2014-2017) were analyzed using survey logistic regression models, adjusting for potential confounders.Measurements and Main Results: SDB (apnea-hypopnea index of 5 or more) and insomnia (Women's Health Initiative Insomnia Rating Scale of 9 or more) were measured at baseline. Incident hypertension (stage 2 or greater) and diabetes were defined according to national guidelines. In the target population, 52.6% were women, with a mean age of 41.1 ± 14.9 years at baseline. SDB was associated with 1.54 higher adjusted odds of incident hypertension (95% confidence interval [CI], 1.18-2.00) and 1.33 higher odds of incident diabetes (95% CI, 1.05-1.67) compared with no SDB. Insomnia was associated with incident hypertension (odds ratio, 1.37; 95% CI, 1.11-1.69) but not with diabetes. The association between insomnia and incident hypertension was stronger among men than among women.Conclusions: SDB was associated with incident hypertension and diabetes. Insomnia was associated with incident hypertension. These findings support the importance of sleep disorders as modifiable targets for disease prevention and reduction. [ABSTRACT FROM AUTHOR]

Published
2021
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31. Abstract P064: Progression From Prediabetes to Diabetes in Hispanics/Latinos. Results From the Hispanic Community Health Study / Study of Latinos (HCHS/SOL)

Author

Pasquel, Francisco J, primary, Loop, Matthew S, additional, Menke, Andy, additional, O'Brien, Matthew J, additional, Vidot, Denise C, additional, Sotres-Alvarez, Daniela, additional, Corsino, Leonor, additional, Talavera, Gregory A, additional, Gallo, Linda C, additional, Kaplan, Robert C, additional, Schneiderman, Neil, additional, Daviglus, Martha L, additional, Cowie, Catherine C, additional, and Aviles-Santa, Larissa, additional

Published
2018
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32. Abstract MP024: Increase in Adverse Cardiovascular Risk Profile among Hispanics/Latinos of Diverse Backgrounds Living in the United States: Findings from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Author

Daviglus, Martha L, primary, Cai, Jianwen, additional, Pirzada, Amber, additional, Butera, Nicole M, additional, Durazo-Arvizu, Ramon A, additional, Lash, James P, additional, Aviles-Santa, Larissa, additional, Gallo, Linda C, additional, Kaplan, Robert, additional, Schneiderman, Neil, additional, Talavera, Gregory A, additional, Wassertheil-Smoller, Sylvia, additional, and Stamler, Jeremiah, additional

Published
2017
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34. Abstract 05: Associations of Objectively-measured Sedentary Time And Physical Activity with Meeting Cardiovascular Risk Factor Control Goals in U.S. Hispanic/Latino Adults with Diabetes: The Hispanic Community Health Study/Study of Latinos (hchs/sol)

Author

Qi, Qibin, primary, Wang, Xueyin, additional, Strizich, Garrett, additional, Sotres-Alvarez, Daniela, additional, Buelna, Christina, additional, Gallo, Linda, additional, Gellman, Marc, additional, Mossavar-Rahmani, Yasmin, additional, O’Brien, Matthew, additional, Stoutenberg, Mark, additional, Wang, Tao, additional, Aviles-Santa, Larissa, additional, and Kaplan, Robert, additional

Published
2016
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35. Effects of Metformin in Patients with Poorly Controlled, Insulin-Treated Type 2 Diabetes Mellitus

Author

Aviles-Santa, Larissa, Sinding, Joyce, and Raskin, Philip

Subjects
Type 2 diabetes -- Drug therapy, Metformin -- Health aspects, Insulin -- Health aspects, Drug therapy, Combination -- Evaluation, Health
Abstract

Background: Patients with type 2 diabetes are often obese and require large doses of insulin to achieve glycemic control. Weight gain often accompanies insulin therapy and results in increasing insulin requirements. Objective: To evaluate the efficacy of metformin in combination with insulin in patients with type 2 diabetes poorly controlled with insulin therapy alone. Design: Randomized, double-blind, placebo-controlled trial. Setting: Outpatient diabetes clinic at a university medical center. Patients: 43 patients with poorly controlled type 2 diabetes who were receiving insulin therapy. Intervention: Patients were randomly assigned to receive placebo or metformin in combination with insulin for 24 weeks. Results: Hemoglobin [A.sub.1c] levels decreased by 2.5 percentage points (95% CI, 1.8 to 3.1 percentage points) in the metformin group, a significantly greater change (P = 0.04) than the decrease of 1.6 percentage points in the placebo group. Average final hemoglobin [A.sub.1c] levels were 6.5% in the metformin group and 7.6% in the placebo group (difference, 11%). For patients who received placebo, the insulin dose increased 22.8 units (CI, 11 to 44 units) or 29% more than did the dose for patients who received metformin (P=0.002); for these patients, the insulin dose decreased slightly. Patients in the placebo group gained an average of 3.2 kg of body weight (CI, 1.2 to 5.1 kg); patients in the metformin group gained an average of 0.5 kg of body weight (P = 0.07). Total cholesterol and low-density lipoprotein cholesterol levels decreased in both groups. High-density lipoprotein cholesterol and triglyceride levels did not change. Conclusions: The addition of metformin to insulin therapy resulted in hemoglobin [A.sub.1c] concentrations that were 10% lower than those achieved by insulin therapy alone. This improvement in glycemic control occurred with the use of 29% less insulin and without significant weight gain. Metformin is an effective adjunct to insulin therapy in patients with type 2 diabetes., Patients who have poorly controlled type 2 diabetes may benefit from the addition of metformin to their insulin therapy. A group of 43 patients with type 2 diabetes which was not under control was divided at random into two groups, one which received metformin in addition to insulin for 24 weeks, and one which did not. The group which received the metformin improved they control of blood sugar by 10% while using 29% less insulin, and without any significant weight gain. Metformin is an effective adjunct to insulin therapy in patients with type 2 diabetes.

Published
1999

37. Type 1.5 Diabetes: A Four-Year Follow Up of a Cohort from Dallas ('Prairie Diabetes')

Author

PINERO-PILONA, ANTONIO, HARRIS, WILLIAM T, LENDER, DAN, and AVILES-SANTA, LARISSA

Subjects
Diabetes -- Research, Health
Abstract

The diabetes of young, obese African-Americans has been called by several names, including Type 1.5 diabetes, atypical diabetes and Flatbush diabetes; we would like to add Prairie Diabetes to the [...]

Published
1999

38. Report of a National Heart, Lung, and Blood Institute Workshop: Heterogeneity in Cardiometabolic Risk in Asian Americans in the U.S.

Author

Narayan, K.M. Venkat, primary, Aviles-Santa, Larissa, additional, Oza-Frank, Reena, additional, Pandey, Mona, additional, Curb, J. David, additional, McNeely, Marguerite, additional, Araneta, Maria Rosario G., additional, Palaniappan, Latha, additional, Rajpathak, Swapnil, additional, and Barrett-Connor, Elizabeth, additional

Published
2010
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40. Report of a National Heart, Lung, and Blood Institute Workshop: Heterogeneity in Cardiometabolic Risk in Asian Americans in the U.S. Opportunities for Research

Author

Narayan, K.M. Venkat, Aviles-Santa, Larissa, Oza-Frank, Reena, Pandey, Mona, Curb, J. David, McNeely, Marguerite, Araneta, Maria Rosario G., Palaniappan, Latha, Rajpathak, Swapnil, and Barrett-Connor, Elizabeth

Subjects
Asian Americans, disparity, cardiovascular disease, ethnicity, type 2 diabetes, Pacific Islanders
Abstract

The Asian and Pacific Islander population (Asian Americans) in the U.S. has increased dramatically in the last few decades. Yet, data on cardiovascular disease (CVD) in this population are scarce. The National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health conducted an Expert Workshop to: 1) assess the importance of studying CVD in Asian Americans in the U.S.; and 2) consider strategic options for further investigations of CVD in this population. There is considerable geographical, ethnic, cultural, and genetic diversity within this population. Limited data also suggest striking differences in the risk of CVD, obesity, type 2 diabetes mellitus, and other CVD risk factors across the Asian-American population. The Asian-American population is a new diverse pool with less contemporary genetic and cultural admixture relative to groups that have lived in the U.S. for generations, plus it is diverse in lifestyle including culture, diet, and family structure. This diversity provides a window of opportunity for research on genes and gene-environment interactions and also to investigate how acculturation/assimilation to U.S. lifestyles affects health and CVD risk among relatively homogenous groups of recent immigrants. Given the heterogeneity in body weight, body size, and CVD risk, the Asian-American population in the U.S. offers a unique model to study the interaction and relationships between visceral adiposity and adipose tissue distribution and beta cell function, insulin resistance, and atherosclerosis.

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41. Increase in Adverse Cardiovascular Risk Profile among Hispanics/Latinos of Diverse Backgrounds Living in the United States: Findings from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

Author

Daviglus, Martha L., Cai, Jianwen, Pirzada, Amber, Butera, Nicole M., Durazo-Arvizu, Ramon A., Lash, James P., Aviles-Santa, Larissa, Gallo, Linda C., Kaplan, Robert, Schneiderman, Neil, Talavera, Gregory A., Wassertheil-Smoller, Sylvia, and Stamler, Jeremiah

Published
2017
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42. Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality.

Author

Magnussen C, Ojeda FM, Leong DP, Alegre-Diaz J, Amouyel P, Aviles-Santa L, De Bacquer D, Ballantyne CM, Bernabé-Ortiz A, Bobak M, Brenner H, Carrillo-Larco RM, de Lemos J, Dobson A, Dörr M, Donfrancesco C, Drygas W, Dullaart RP, Engström G, Ferrario MM, Ferrières J, de Gaetano G, Goldbourt U, Gonzalez C, Grassi G, Hodge AM, Hveem K, Iacoviello L, Ikram MK, Irazola V, Jobe M, Jousilahti P, Kaleebu P, Kavousi M, Kee F, Khalili D, Koenig W, Kontsevaya A, Kuulasmaa K, Lackner KJ, Leistner DM, Lind L, Linneberg A, Lorenz T, Lyngbakken MN, Malekzadeh R, Malyutina S, Mathiesen EB, Melander O, Metspalu A, Miranda JJ, Moitry M, Mugisha J, Nalini M, Nambi V, Ninomiya T, Oppermann K, d'Orsi E, Pająk A, Palmieri L, Panagiotakos D, Perianayagam A, Peters A, Poustchi H, Prentice AM, Prescott E, Risérus U, Salomaa V, Sans S, Sakata S, Schöttker B, Schutte AE, Sepanlou SG, Sharma SK, Shaw JE, Simons LA, Söderberg S, Tamosiunas A, Thorand B, Tunstall-Pedoe H, Twerenbold R, Vanuzzo D, Veronesi G, Waibel J, Wannamethee SG, Watanabe M, Wild PS, Yao Y, Zeng Y, Ziegler A, and Blankenberg S

Subjects
Female, Humans, Male, Middle Aged, Diabetes Mellitus, Risk Factors, Smoking adverse effects, Internationality, Cardiovascular Diseases epidemiology, Cardiovascular Diseases mortality, Heart Disease Risk Factors
Abstract

Background: Five modifiable risk factors are associated with cardiovascular disease and death from any cause. Studies using individual-level data to evaluate the regional and sex-specific prevalence of the risk factors and their effect on these outcomes are lacking., Methods: We pooled and harmonized individual-level data from 112 cohort studies conducted in 34 countries and 8 geographic regions participating in the Global Cardiovascular Risk Consortium. We examined associations between the risk factors (body-mass index, systolic blood pressure, non-high-density lipoprotein cholesterol, current smoking, and diabetes) and incident cardiovascular disease and death from any cause using Cox regression analyses, stratified according to geographic region, age, and sex. Population-attributable fractions were estimated for the 10-year incidence of cardiovascular disease and 10-year all-cause mortality., Results: Among 1,518,028 participants (54.1% of whom were women) with a median age of 54.4 years, regional variations in the prevalence of the five modifiable risk factors were noted. Incident cardiovascular disease occurred in 80,596 participants during a median follow-up of 7.3 years (maximum, 47.3), and 177,369 participants died during a median follow-up of 8.7 years (maximum, 47.6). For all five risk factors combined, the aggregate global population-attributable fraction of the 10-year incidence of cardiovascular disease was 57.2% (95% confidence interval [CI], 52.4 to 62.1) among women and 52.6% (95% CI, 49.0 to 56.1) among men, and the corresponding values for 10-year all-cause mortality were 22.2% (95% CI, 16.8 to 27.5) and 19.1% (95% CI, 14.6 to 23.6)., Conclusions: Harmonized individual-level data from a global cohort showed that 57.2% and 52.6% of cases of incident cardiovascular disease among women and men, respectively, and 22.2% and 19.1% of deaths from any cause among women and men, respectively, may be attributable to five modifiable risk factors. (Funded by the German Center for Cardiovascular Research (DZHK); ClinicalTrials.gov number, NCT05466825.)., (Copyright © 2023 Massachusetts Medical Society.)

Published
2023
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43. The trans-ancestral genomic architecture of glycemic traits.

Author

Chen J, Spracklen CN, Marenne G, Varshney A, Corbin LJ, Luan J, Willems SM, Wu Y, Zhang X, Horikoshi M, Boutin TS, Mägi R, Waage J, Li-Gao R, Chan KHK, Yao J, Anasanti MD, Chu AY, Claringbould A, Heikkinen J, Hong J, Hottenga JJ, Huo S, Kaakinen MA, Louie T, März W, Moreno-Macias H, Ndungu A, Nelson SC, Nolte IM, North KE, Raulerson CK, Ray D, Rohde R, Rybin D, Schurmann C, Sim X, Southam L, Stewart ID, Wang CA, Wang Y, Wu P, Zhang W, Ahluwalia TS, Appel EVR, Bielak LF, Brody JA, Burtt NP, Cabrera CP, Cade BE, Chai JF, Chai X, Chang LC, Chen CH, Chen BH, Chitrala KN, Chiu YF, de Haan HG, Delgado GE, Demirkan A, Duan Q, Engmann J, Fatumo SA, Gayán J, Giulianini F, Gong JH, Gustafsson S, Hai Y, Hartwig FP, He J, Heianza Y, Huang T, Huerta-Chagoya A, Hwang MY, Jensen RA, Kawaguchi T, Kentistou KA, Kim YJ, Kleber ME, Kooner IK, Lai S, Lange LA, Langefeld CD, Lauzon M, Li M, Ligthart S, Liu J, Loh M, Long J, Lyssenko V, Mangino M, Marzi C, Montasser ME, Nag A, Nakatochi M, Noce D, Noordam R, Pistis G, Preuss M, Raffield L, Rasmussen-Torvik LJ, Rich SS, Robertson NR, Rueedi R, Ryan K, Sanna S, Saxena R, Schraut KE, Sennblad B, Setoh K, Smith AV, Sparsø T, Strawbridge RJ, Takeuchi F, Tan J, Trompet S, van den Akker E, van der Most PJ, Verweij N, Vogel M, Wang H, Wang C, Wang N, Warren HR, Wen W, Wilsgaard T, Wong A, Wood AR, Xie T, Zafarmand MH, Zhao JH, Zhao W, Amin N, Arzumanyan Z, Astrup A, Bakker SJL, Baldassarre D, Beekman M, Bergman RN, Bertoni A, Blüher M, Bonnycastle LL, Bornstein SR, Bowden DW, Cai Q, Campbell A, Campbell H, Chang YC, de Geus EJC, Dehghan A, Du S, Eiriksdottir G, Farmaki AE, Frånberg M, Fuchsberger C, Gao Y, Gjesing AP, Goel A, Han S, Hartman CA, Herder C, Hicks AA, Hsieh CH, Hsueh WA, Ichihara S, Igase M, Ikram MA, Johnson WC, Jørgensen ME, Joshi PK, Kalyani RR, Kandeel FR, Katsuya T, Khor CC, Kiess W, Kolcic I, Kuulasmaa T, Kuusisto J, Läll K, Lam K, Lawlor DA, Lee NR, Lemaitre RN, Li H, Lin SY, Lindström J, Linneberg A, Liu J, Lorenzo C, Matsubara T, Matsuda F, Mingrone G, Mooijaart S, Moon S, Nabika T, Nadkarni GN, Nadler JL, Nelis M, Neville MJ, Norris JM, Ohyagi Y, Peters A, Peyser PA, Polasek O, Qi Q, Raven D, Reilly DF, Reiner A, Rivideneira F, Roll K, Rudan I, Sabanayagam C, Sandow K, Sattar N, Schürmann A, Shi J, Stringham HM, Taylor KD, Teslovich TM, Thuesen B, Timmers PRHJ, Tremoli E, Tsai MY, Uitterlinden A, van Dam RM, van Heemst D, van Hylckama Vlieg A, van Vliet-Ostaptchouk JV, Vangipurapu J, Vestergaard H, Wang T, Willems van Dijk K, Zemunik T, Abecasis GR, Adair LS, Aguilar-Salinas CA, Alarcón-Riquelme ME, An P, Aviles-Santa L, Becker DM, Beilin LJ, Bergmann S, Bisgaard H, Black C, Boehnke M, Boerwinkle E, Böhm BO, Bønnelykke K, Boomsma DI, Bottinger EP, Buchanan TA, Canouil M, Caulfield MJ, Chambers JC, Chasman DI, Chen YI, Cheng CY, Collins FS, Correa A, Cucca F, de Silva HJ, Dedoussis G, Elmståhl S, Evans MK, Ferrannini E, Ferrucci L, Florez JC, Franks PW, Frayling TM, Froguel P, Gigante B, Goodarzi MO, Gordon-Larsen P, Grallert H, Grarup N, Grimsgaard S, Groop L, Gudnason V, Guo X, Hamsten A, Hansen T, Hayward C, Heckbert SR, Horta BL, Huang W, Ingelsson E, James PS, Jarvelin MR, Jonas JB, Jukema JW, Kaleebu P, Kaplan R, Kardia SLR, Kato N, Keinanen-Kiukaanniemi SM, Kim BJ, Kivimaki M, Koistinen HA, Kooner JS, Körner A, Kovacs P, Kuh D, Kumari M, Kutalik Z, Laakso M, Lakka TA, Launer LJ, Leander K, Li H, Lin X, Lind L, Lindgren C, Liu S, Loos RJF, Magnusson PKE, Mahajan A, Metspalu A, Mook-Kanamori DO, Mori TA, Munroe PB, Njølstad I, O'Connell JR, Oldehinkel AJ, Ong KK, Padmanabhan S, Palmer CNA, Palmer ND, Pedersen O, Pennell CE, Porteous DJ, Pramstaller PP, Province MA, Psaty BM, Qi L, Raffel LJ, Rauramaa R, Redline S, Ridker PM, Rosendaal FR, Saaristo TE, Sandhu M, Saramies J, Schneiderman N, Schwarz P, Scott LJ, Selvin E, Sever P, Shu XO, Slagboom PE, Small KS, Smith BH, Snieder H, Sofer T, Sørensen TIA, Spector TD, Stanton A, Steves CJ, Stumvoll M, Sun L, Tabara Y, Tai ES, Timpson NJ, Tönjes A, Tuomilehto J, Tusie T, Uusitupa M, van der Harst P, van Duijn C, Vitart V, Vollenweider P, Vrijkotte TGM, Wagenknecht LE, Walker M, Wang YX, Wareham NJ, Watanabe RM, Watkins H, Wei WB, Wickremasinghe AR, Willemsen G, Wilson JF, Wong TY, Wu JY, Xiang AH, Yanek LR, Yengo L, Yokota M, Zeggini E, Zheng W, Zonderman AB, Rotter JI, Gloyn AL, McCarthy MI, Dupuis J, Meigs JB, Scott RA, Prokopenko I, Leong A, Liu CT, Parker SCJ, Mohlke KL, Langenberg C, Wheeler E, Morris AP, and Barroso I

Subjects
Alleles, Epigenesis, Genetic, Gene Expression Profiling, Genome, Human, Genome-Wide Association Study, Glycated Hemoglobin metabolism, Humans, Multifactorial Inheritance genetics, Physical Chromosome Mapping, Quantitative Trait Loci genetics, Blood Glucose genetics, Quantitative Trait, Heritable, White People genetics
Abstract

Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P < 5 × 10 -8 ), 80% of which had no significant evidence of between-ancestry heterogeneity. Analyses restricted to individuals of European ancestry with equivalent sample size would have led to 24 fewer new loci. Compared with single-ancestry analyses, equivalent-sized trans-ancestry fine-mapping reduced the number of estimated variants in 99% credible sets by a median of 37.5%. Genomic-feature, gene-expression and gene-set analyses revealed distinct biological signatures for each trait, highlighting different underlying biological pathways. Our results increase our understanding of diabetes pathophysiology by using trans-ancestry studies for improved power and resolution.

Published
2021
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