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139 results on '"Awadallah, Amad"'

4. Supplemental Figures and Tables from Immune Signatures Following Single Dose Trastuzumab Predict Pathologic Response to PreoperativeTrastuzumab and Chemotherapy in HER2-Positive Early Breast Cancer

Author

Varadan, Vinay, primary, Gilmore, Hannah, primary, Miskimen, Kristy L.S., primary, Tuck, David, primary, Parsai, Shikha, primary, Awadallah, Amad, primary, Krop, Ian E., primary, Winer, Eric P., primary, Bossuyt, Veerle, primary, Somlo, George, primary, Abu-Khalaf, Maysa M., primary, Fenton, Mary Anne, primary, Sikov, William, primary, and Harris, Lyndsay N., primary

Published
2023
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5. Supplemental Figure Legends from Aberrant Notch Signaling in the Bone Marrow Microenvironment of Acute Lymphoid Leukemia Suppresses Osteoblast-Mediated Support of Hematopoietic Niche Function

Author

Wang, Weihuan, primary, Zimmerman, Grant, primary, Huang, Xiaoran, primary, Yu, Shuiliang, primary, Myers, Jay, primary, Wang, Yiwei, primary, Moreton, Stephen, primary, Nthale, Joseph, primary, Awadallah, Amad, primary, Beck, Rose, primary, Xin, Wei, primary, Wald, David, primary, Huang, Alex Y., primary, and Zhou, Lan, primary

Published
2023
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6. Data from Aberrant Notch Signaling in the Bone Marrow Microenvironment of Acute Lymphoid Leukemia Suppresses Osteoblast-Mediated Support of Hematopoietic Niche Function

Author

Wang, Weihuan, primary, Zimmerman, Grant, primary, Huang, Xiaoran, primary, Yu, Shuiliang, primary, Myers, Jay, primary, Wang, Yiwei, primary, Moreton, Stephen, primary, Nthale, Joseph, primary, Awadallah, Amad, primary, Beck, Rose, primary, Xin, Wei, primary, Wald, David, primary, Huang, Alex Y., primary, and Zhou, Lan, primary

Published
2023
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7. Supplemental Information from Aberrant Notch Signaling in the Bone Marrow Microenvironment of Acute Lymphoid Leukemia Suppresses Osteoblast-Mediated Support of Hematopoietic Niche Function

Author

Wang, Weihuan, primary, Zimmerman, Grant, primary, Huang, Xiaoran, primary, Yu, Shuiliang, primary, Myers, Jay, primary, Wang, Yiwei, primary, Moreton, Stephen, primary, Nthale, Joseph, primary, Awadallah, Amad, primary, Beck, Rose, primary, Xin, Wei, primary, Wald, David, primary, Huang, Alex Y., primary, and Zhou, Lan, primary

Published
2023
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8. Supplemental Figures from Aberrant Notch Signaling in the Bone Marrow Microenvironment of Acute Lymphoid Leukemia Suppresses Osteoblast-Mediated Support of Hematopoietic Niche Function

Author

Wang, Weihuan, primary, Zimmerman, Grant, primary, Huang, Xiaoran, primary, Yu, Shuiliang, primary, Myers, Jay, primary, Wang, Yiwei, primary, Moreton, Stephen, primary, Nthale, Joseph, primary, Awadallah, Amad, primary, Beck, Rose, primary, Xin, Wei, primary, Wald, David, primary, Huang, Alex Y., primary, and Zhou, Lan, primary

Published
2023
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12. Late Recurrence of Colorectal Carcinoma in Patients with Malignant Polyp and Risk Factors.

Author

Cui, Min, Sadri, Navid, Awadallah, Amad, Zhou, Lan, and Xin, Wei

Subjects
COLORECTAL cancer, POLYPS, SURGICAL margin, MISSENSE mutation, ENDOSCOPIC surgery, ARACHNOID cysts
Abstract

Malignant polyps are polypoid lesions that appear benign endoscopically but harbor invasive adenocarcinoma microscopically. Patient with diagnosis of malignant polyp can be managed by surgical resection or endoscopic surveillance. Current literature on long term recurrence is sparse. A total of 76 patients with malignant polyp and follow-up period of over one year are included. Of these, 28 patients underwent endoscopic polypectomy followed by surveillance (group 1). Forty-eight patients underwent segmental colectomy (group 2). In group 1, three patients developed local recurrent pT3 adenocarcinoma (5.9 to 9.7 years) and one patient developed liver metastasis (7.3 years). One patient presented with malignant polyp in another segment of colon (4.0 years). Two of the malignant polyps with local recurrence do not have commonly reported high-risk features, including tumor ≤ 1 mm from resection margin, presence of lymphovascular invasion and high grade tumor, they had invasion depth of >4 mm and harbored a TP53 missense mutation. In group 2, during the follow-up period (1.0-21.8 years, median 9.3 years), none of the patients developed local recurrence. In this study, surveillance group had a local late recurrence rate of 10.7% versus no local recurrence in surgical resection group (0%). Our study shows that depth of invasion of over 4 mm in malignant polyp is a risk factor for late local recurrence if managed by endoscopic surveillance. Further study is needed to explore whether certain molecular alterations, such as TP53 mutation, is a risk factor for late recurrence. [ABSTRACT FROM AUTHOR]

Published
2023
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14. sj-docx-1-ijs-10.1177_10668969221113498 - Supplemental material for Late Recurrence of Colorectal Carcinoma in Patients with Malignant Polyp and Risk Factors

Author

Cui, Min, Sadri, Navid, Awadallah, Amad, Zhou, Lan, and Xin, Wei

Subjects
FOS: Clinical medicine, 110323 Surgery, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental material, sj-docx-1-ijs-10.1177_10668969221113498 for Late Recurrence of Colorectal Carcinoma in Patients with Malignant Polyp and Risk Factors by Min Cui, Navid Sadri, Amad Awadallah, Lan Zhou and Wei Xin in International Journal of Surgical Pathology

Published
2022
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16. Endothelial PERK-ATF4-JAG1 axis activated by T-ALL remodels bone marrow vascular niche

Author

Liu, Cui, primary, Chen, Qiuyun, additional, Shang, Yinghui, additional, Chen, Lechuang, additional, Myers, Jay, additional, Awadallah, Amad, additional, Sun, Jinger, additional, Yu, Shuiliang, additional, Umphred-Wilson, Katharine, additional, Che, Danian, additional, Dou, Yingtong, additional, Li, Luoyi, additional, Wearsch, Pamela, additional, Ramírez-Bergeron, Diana, additional, Beck, Rose, additional, Xin, Wei, additional, Jin, Ge, additional, Adoro, Stanley, additional, and Zhou, Lan, additional

Published
2022
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17. Notch-Regulated Dendritic Cells Restrain Inflammation-Associated Colorectal Carcinogenesis

Author

Wang, Lei, primary, Yu, Shuiliang, additional, Chan, Ernest R., additional, Chen, Kai-Yuan, additional, Liu, Cui, additional, Che, Danian, additional, Awadallah, Amad, additional, Myers, Jay, additional, Askew, David, additional, Huang, Alex Y., additional, Maillard, Ivan, additional, Huang, Dan, additional, Xin, Wei, additional, and Zhou, Lan, additional

Published
2021
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24. Endochondral Ossification in Critical-Sized Bone Defects via Readily Implantable Scaffold-Free Stem Cell Constructs

Author

Dang, Phuong N., primary, Herberg, Samuel, additional, Varghai, Davood, additional, Riazi, Hooman, additional, Varghai, Daniel, additional, McMillan, Alexandra, additional, Awadallah, Amad, additional, Phillips, Lauren M., additional, Jeon, Oju, additional, Nguyen, Minh K., additional, Dwivedi, Neha, additional, Yu, Xiaohua, additional, Murphy, William L., additional, and Alsberg, Eben, additional

Published
2017
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26. Immune Signatures Following Single Dose Trastuzumab Predict Pathologic Response to PreoperativeTrastuzumab and Chemotherapy in HER2-Positive Early Breast Cancer

Author

Varadan, Vinay, primary, Gilmore, Hannah, additional, Miskimen, Kristy L.S., additional, Tuck, David, additional, Parsai, Shikha, additional, Awadallah, Amad, additional, Krop, Ian E., additional, Winer, Eric P., additional, Bossuyt, Veerle, additional, Somlo, George, additional, Abu-Khalaf, Maysa M., additional, Fenton, Mary Anne, additional, Sikov, William, additional, and Harris, Lyndsay N., additional

Published
2016
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28. Loss of ARID1A/BAF250a expression in ovarian endometriosis and clear cell carcinoma

Author

Xiao, Wenbin, Awadallah, Amad, and Xin, Wei

Subjects
Ovarian Neoplasms, Endometriosis, Nuclear Proteins, Cystadenocarcinoma, Serous, Up-Regulation, DNA-Binding Proteins, Adenocarcinoma, Papillary, Cell Transformation, Neoplastic, Receptors, Estrogen, Humans, Original Article, Female, Tumor Suppressor Protein p53, Receptors, Progesterone, Precancerous Conditions, Adenocarcinoma, Clear Cell, Hepatocyte Nuclear Factor 1-beta, Transcription Factors
Abstract

Ovarian endometriosis has been associated with increased risk for ovarian clear cell carcinoma (CCC). Atypical endometriosis shares common molecular alterations with CCC and therefore, has been proposed as a precursor lesion of CCC, although it is unclear if benign endometriosis is pre-neoplastic. In this study, we examined some molecular alterations in ovarian benign endometriosis, atypical endometriosis, and CCC in comparison to papillary serous carcinoma (PSC). These included BAF250a (encoded by ARID1A), a recently identified major tumor suppressor in ovarian CCC, as well as hepatocyte nuclear factor (HNF)-1b, estrogen receptor (ER), progesterone receptor (PR), and P53. We confirmed that CCC but not PSC had loss of BAF250a expression, HNF-1b up-regulation, loss of ER expression and P53 expression. We further showed that both atypical endometriosis and adjacent CCC had loss of BAF250a expression (38.5% vs. 57.7%), HNF-1b up-regulation (53.8% vs. 92.3%), and loss of ER (84.6% vs. 92.3%) and PR (76.9% vs. 84.6%) expression. Importantly, about 20% of benign ovarian endometriosis had loss of BAF250a expression, 33% with HNF-1b up-regulation, 23% loss of ER expression and 50% loss of PR expression, respectively. The concurrent rate of loss of BAF250a expression, HNF-1b up-regulation, and loss of ER expression was not observed in any benign endometriosis, and was increased to 23.1% in atypical endometriosis, and was further increased to 42.3% in CCC. Therefore, the molecular alterations accumulate in a stepwise manner along the transformation process from benign endometriosis through atypical endometriosis to CCC. These data suggest that a portion of benign ovarian endometriosis has already undergone genetic alterations that lead to aberrant protein expression, possibly conferring a higher risk for malignant transformation.

Published
2012

29. Aberrant Notch Signaling in the Bone Marrow Microenvironment of Acute Lymphoid Leukemia Suppresses Osteoblast-Mediated Support of Hematopoietic Niche Function

Author

Wang, Weihuan, primary, Zimmerman, Grant, additional, Huang, Xiaoran, additional, Yu, Shuiliang, additional, Myers, Jay, additional, Wang, Yiwei, additional, Moreton, Stephen, additional, Nthale, Joseph, additional, Awadallah, Amad, additional, Beck, Rose, additional, Xin, Wei, additional, Wald, David, additional, Huang, Alex Y., additional, and Zhou, Lan, additional

Published
2016
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31. CD1c(+) myeloid dendritic cells in myeloid neoplasia

Author

Meyerson, Howard J., primary, Osei, Ebenezer, additional, Schweitzer, Karen, additional, Blidaru, Georgetta, additional, Edinger, Alison, additional, Schlegelmilch, June, additional, Awadallah, Amad, additional, and Goyal, Tanu, additional

Published
2015
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38. Transcriptional profiling of human mesenchymal stem cells transduced with reporter genes for imaging

Author

Wang, Fangjing, primary, Dennis, James E., additional, Awadallah, Amad, additional, Solchaga, Luis A., additional, Molter, Joseph, additional, Kuang, Yu, additional, Salem, Nicolas, additional, Lin, Yuan, additional, Tian, Haibin, additional, Kolthammer, Jeffery A., additional, Kim, Yunhui, additional, Love, Zachary B., additional, Gerson, Stanton L., additional, and Lee, Zhenghong, additional

Published
2009
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48. Transcriptional profiling of human mesenchymal stem cells transduced with reporter genes for imaging.

Author

Fangjing Wang, Dennis, James E., Awadallah, Amad, Solchaga, Luis A., Molter, Joseph, Yu Kuang, Salem, Nicolas, Yuan Lin, Haibin Tian, Kolthammer, Jeffery A., Yunhui Kim, Love, Zachary B., Gerson, Stanton L., and Zhenghong Lee

Abstract

Mesenchymal stem cells (MSCs) can differentiate into osteogenic, adipogenic, chondrogenic, myocardial, or neural lineages when exposed to specific stimuli, making them attractive for tissue repair and regeneration. We have used reporter gene-based imaging technology to track MSC transplantation or implantation in vivo. However, the effects of lentiviral transduction with the fluc-mrfp-ttk triple-fusion vector on the transcriptional profiles of MSCs remain unknown. In this study, gene expression differences between wild-type and transduced hMSCs were evaluated using an oligonucleotide human microarray. Significance Analysis of Microarray identified differential genes with high accuracy; RT-PCR validated the microarray results. Annotation analysis showed that transduced hMSCs upregulated cell differentiation and antiapoptosis genes while downregulating cell cycle, proliferation genes. Despite transcriptional changes associated with bone and cartilage remodeling, their random pattern indicates no systematic change of crucial genes that are associated with osteogenic, adipogenic, or chondrogenic differentiation. This correlates with the experimental results that lentiviral transduction did not cause the transduced MSCs to lose their basic stem cell identity as demonstrated by osteogenic, chondrogenic, and adipogenic differentiation assays with both transduced and wild-type MSCs, although a certain degree of alterations occurred. Histological analysis demonstrated osteogenic differentiation in MSC-loaded ceramic cubes in vivo. In conclusion, transduction of reporter genes into MSCs preserved the basic properties of stem cells while enabling noninvasive imaging in living animals to study the biodistribution and other biological activities of the cells. [ABSTRACT FROM AUTHOR]

Published
2009
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50. Clinical-Scale Expansion of a Mixed Population of Bone Marrow-Derived Stem and Progenitor Cells for Potential Use in Bone Tissue Regeneration.

Author

James E. Dennis, Esterly, Kelly, Awadallah, Amad, Parrish, Christopher R., Poynter, Gregory M., and Goltry, Kritin L.

Subjects
BONE marrow, BONE growth, BIOREACTORS, MONONUCLEOSIS, HEMATOPOIETIC system
Abstract

Preclinical and clinical studies have demonstrated the ability of bone marrow derived stem and progenitor cells to regenerate many tissues, including bone. Methods to expand or enrich progenitors from bone marrow are common; however, these methods include many steps not amenable to clinical use. A closed automated cell production culture system was developed for clinical-scale ex vivo production of bone marrow-derived stem and progenitor cells for hematopoietic reconstitution. The current study tested the ability of this bioreactor system to produce progenitor cells, termed tissue repair cells (TRC), possessing osteogenic potential. Three TRC formulations were evaluated: (a) cells cultured without exogenous cytokines (TRC); (b) cells cultured with exogenous cytokines (TRC-C); and (c) an adherent subset of TRC-C (TRC-CAd). Starting human bone marrow mononuclear cells (BM MNC) and TRC products were characterized for the expression of cell surface markers, in vitro colony forming ability, and in vivo osteogenic potential. Results showed significant expansion of mesenchymal progenitors (CD90+, CD105+, and CD166+) in each TRC formulation. In vivo bone formation, measured by histology, was highest in the TRC group, followed by TRC-CAd and TRC-C. The TRC product outperformed starting BM MNC and had equivalent bone forming potential to purified MSCs at the same cell dose. Post hoc analysis revealed that the presence of CD90+, CD105+, and CD166+ correlated strongly with in vivo bone formation scores (r² > .95). These results demonstrate that this bioreactor system can be used to generate, in a single step, a population of progenitor cells with potent osteogenic potential. [ABSTRACT FROM AUTHOR]

Published
2007
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