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1. Drug resistance and vaccine target surveillance of Plasmodium falciparum using nanopore sequencing in Ghana

Author

Girgis, Sophia T., Adika, Edem, Nenyewodey, Felix E., Senoo Jnr, Dodzi K., Ngoi, Joyce M., Bandoh, Kukua, Lorenz, Oliver, van de Steeg, Guus, Harrott, Alexandria J. R., Nsoh, Sebastian, Judge, Kim, Pearson, Richard D., Almagro-Garcia, Jacob, Saiid, Samirah, Atampah, Solomon, Amoako, Enock K., Morang’a, Collins M., Asoala, Victor, Adjei, Elrmion S., Burden, William, Roberts-Sengier, William, Drury, Eleanor, Pierce, Megan L., Gonçalves, Sónia, Awandare, Gordon A., Kwiatkowski, Dominic P., Amenga-Etego, Lucas N., and Hamilton, William L.

Published
2023
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3. Cellular immune response to SARS-CoV-2 and clinical presentation in individuals exposed to endemic malaria

Author

Tapela, Kesego, Prah, Diana Ahu, Tetteh, Becky, Nuokpem, Franklin, Dosoo, Daniel, Coker, Amin, Kumi-Ansah, Frederick, Amoako, Emmanuella, Assah, Kissi Ohene, Kilba, Charlyne, Nyakoe, Nancy, Quansah, Darius, Languon, Sylvester, Anyigba, Claudia Adzo, Ansah, Felix, Agyeman, Seth, Owusu, Irene Amoakoh, Schneider, Kristan, Ampofo, William K., Mutungi, Joe Kimanthi, Amegatcher, Gloria, Aniweh, Yaw, Awandare, Gordon A., Quashie, Peter K., and Bediako, Yaw

Published
2024
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7. The temporal dynamics of Plasmodium species infection after artemisinin-based combination therapy (ACT) among asymptomatic children in the Hohoe municipality, Ghana

Author

Ansah, Felix, Nyame, Kwamina, Laryea, Rukaya, Owusu, Richard, Amon, Denick, Boyetey, Mark-Jefferson Buer, Ayeke, Dzidzor, Razak, Nasibatu, Kornu, Victor E., Ashitei, Sarah, Owusu-Appiah, Caleb, Chirawurah, Jersley D., Abugri, James, Aniweh, Yaw, Opoku, Nicholas, Sutherland, Colin J., Binka, Fred N., Kweku, Margaret, Awandare, Gordon A., and Dinko, Bismarck

Published
2023
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9. Detection of SARS-CoV-2 intra-host recombination during superinfection with Alpha and Epsilon variants in New York City

Author

Wertheim, Joel O, Wang, Jade C, Leelawong, Mindy, Martin, Darren P, Havens, Jennifer L, Chowdhury, Moinuddin A, Pekar, Jonathan E, Amin, Helly, Arroyo, Anthony, Awandare, Gordon A, Chow, Hoi Yan, Gonzalez, Edimarlyn, Luoma, Elizabeth, Morang’a, Collins M, Nekrutenko, Anton, Shank, Stephen D, Silver, Stefan, Quashie, Peter K, Rakeman, Jennifer L, Ruiz, Victoria, Torian, Lucia V, Vasylyeva, Tetyana I, Kosakovsky Pond, Sergei L, and Hughes, Scott

Subjects
Microbiology, Biological Sciences, Bioinformatics and Computational Biology, Genetics, Biotechnology, Human Genome, Vaccine Related, Infectious Diseases, Emerging Infectious Diseases, Prevention, Biodefense, Lung, Pneumonia, Aetiology, 2.1 Biological and endogenous factors, Infection, Good Health and Well Being, COVID-19, Genome, Viral, Humans, New York City, Recombination, Genetic, SARS-CoV-2, Spike Glycoprotein, Coronavirus, Superinfection
Abstract

Recombination is an evolutionary process by which many pathogens generate diversity and acquire novel functions. Although a common occurrence during coronavirus replication, detection of recombination is only feasible when genetically distinct viruses contemporaneously infect the same host. Here, we identify an instance of SARS-CoV-2 superinfection, whereby an individual was infected with two distinct viral variants: Alpha (B.1.1.7) and Epsilon (B.1.429). This superinfection was first noted when an Alpha genome sequence failed to exhibit the classic S gene target failure behavior used to track this variant. Full genome sequencing from four independent extracts reveals that Alpha variant alleles comprise around 75% of the genomes, whereas the Epsilon variant alleles comprise around 20% of the sample. Further investigation reveals the presence of numerous recombinant haplotypes spanning the genome, specifically in the spike, nucleocapsid, and ORF 8 coding regions. These findings support the potential for recombination to reshape SARS-CoV-2 genetic diversity.

Published
2022

12. Validation of two parent-reported autism spectrum disorders screening tools M-CHAT-R and SCQ in Bamako, Mali

Author

Sangare, Modibo, Toure, Hamza B, Toure, Amadou, Karembe, Adama, Dolo, Housseini, Coulibaly, Yaya I, Kouyate, Modibo, Traore, Kadiatou, Diakité, Seidina A, Coulibaly, Souleymane, Togora, Arouna, Guinto, Cheick Oumar, Awandare, Gordon A, Doumbia, Seydou, Diakite, Mahamadou, and Geschwind, Daniel H

Subjects
Health Services and Systems, Biomedical and Clinical Sciences, Health Sciences, Brain Disorders, Prevention, Intellectual and Developmental Disabilities (IDD), Mental Health, Pediatric, Autism, Clinical Research, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, AMALDEME, Malian association for mental deficiencies, ASD, Autism spectrum disorders, AUC, Area under the Curve, CHU, University hospital centers, CSCOM, Community health centers, CSRef, District health centers, DNS, National direction of health, DRS, Regional direction of health, DSM-V, Diagnostic and Statistical Manual of Mental Disorders, FAPH, Faculty of Pharmacy, FMOS, Faculty of medicine and odonto-stomatology, ICD-10, International Statistical Classification of Diseases and Related Health Problems-10, LR+, Positive likelihood, LR-, Negative likelihood, M-CHAT-R, M-CHAT-R, Modified checklist for autism in toddlers-Revised, M-CHAT-R/F, Modified checklist for autism in toddlers-Revised/Follow up, Mali, NPV, NPV, Negative predictive value, PPV, PPV, Positive predictive value, SCQ, SCQ, Social communication questionnaire, USTTB, University of Sciences, Techniques and Technologies of Bamako
Abstract

BackgroundEarly screening is crucial for early autism spectrum disorders (ASD) diagnosis and intervention. ASD screening tools have mostly been constructed based on the Western cultural context. We hypothesized that their use in Mali may require a prior validation.ObjectiveTo validate the modified checklist for autism in toddlers-Revised (M-CHAT-R) and the social communication questionnaire (SCQ) in the Malian sociocultural context for ASD screening.Study designWe administered M-CHAT-R and SCQ in 947 toddlers aged 16-30 months old at the district and community health centers in Bamako and 120 patients (60 autistic and 60 age and sex matched controls) aged ≥4 years old at the psychiatry department in Bamako. Toddlers at moderate to high risk of ASD underwent M-CHAT-R/F and clinical evaluation by an ASD multidisciplinary team. M-CHAT-R and SCQ were evaluated for cultural appropriateness by Malian anthropologists. The sensitivity, specificity, PPV, NPV were determined for both M-CHAT-R and SCQ. Health professionals have been trained during ASD seminary on how to use M-CHAT-R and SCQ for ASD screening in Bamako.ResultsWe found for the M-CHAT-R a sensitivity of 50%, a specificity of 100%, a PPV of 100% and a NPV of 87%. The SCQ had a sensitivity of 71%, a specificity of 72%, a PPV of 73% and a NPV of 70%. We have found four out of 20 items on the M-CHAT-R that were culturally inappropriate in the Malian context.DiscussionM-CHAT-R and SCQ can be used for early autism screening in Mali. In the future, we plan to train a descent number of Malian physicians in chief and pediatricians at the district hospitals across the country to integrate the early ASD screening into the national health system.ConclusionM-CHAT-R has a perfect specificity and SCQ a fair diagnostic accuracy for ASD in Mali.

Published
2019

16. Genetic diversity of SARS-CoV-2 infections in Ghana from 2020-2021

Author

Morang’a, Collins M., Ngoi, Joyce M., Gyamfi, Jones, Amuzu, Dominic S. Y., Nuertey, Benjamin D., Soglo, Philip M., Appiah, Vincent, Asante, Ivy A., Owusu-Oduro, Paul, Armoo, Samuel, Adu-Gyasi, Dennis, Amoako, Nicholas, Oliver-Commey, Joseph, Owusu, Michael, Sylverken, Augustina, Fenteng, Edward D., M’cormack, Violette V., Tei-Maya, Frederick, Quansah, Evelyn B., Ayivor-Djanie, Reuben, Amoako, Enock K., Ogbe, Isaac T., Yemi, Bright K., Osei-Wusu, Israel, Mettle, Deborah N. A., Saiid, Samirah, Tapela, Kesego, Dzabeng, Francis, Magnussen, Vanessa, Quaye, Jerry, Opurum, Precious C., Carr, Rosina A., Ababio, Patrick T., Abass, Abdul-Karim, Akoriyea, Samuel K., Amoako, Emmanuella, Kumi-Ansah, Frederick, Boakye, Oliver D., Mibut, Dam K., Odoom, Theophilus, Ofori-Boadu, Lawrence, Allegye-Cudjoe, Emmanuel, Dassah, Sylvester, Asoala, Victor, Asante, Kwaku P., Phillips, Richard O., Osei-Atweneboana, Mike Y., Gyapong, John O., Kuma-Aboagye, Patrick, Ampofo, William K., Duedu, Kwabena O., Ndam, Nicaise T., Bediako, Yaw, Quashie, Peter K., Amenga-Etego, Lucas N., and Awandare, Gordon A.

Published
2022
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17. Exome sequencing of families from Ghana reveals known and candidate hearing impairment genes

Author

Wonkam, Ambroise, Adadey, Samuel Mawuli, Schrauwen, Isabelle, Aboagye, Elvis Twumasi, Wonkam-Tingang, Edmond, Esoh, Kevin, Popel, Kalinka, Manyisa, Noluthando, Jonas, Mario, deKock, Carmen, Nembaware, Victoria, Cornejo Sanchez, Diana M., Bharadwaj, Thashi, Nasir, Abdul, Everard, Jenna L., Kadlubowska, Magda K., Nouel-Saied, Liz M., Acharya, Anushree, Quaye, Osbourne, Amedofu, Geoffrey K., Awandare, Gordon A., and Leal, Suzanne M.

Published
2022
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18. Probing SARS-CoV-2-positive plasma to identify potential factors correlating with mild COVID-19 in Ghana, West Africa

Author

Tapela, Kesego, Oyawoye, Fatima O., Olwal, Charles Ochieng’, Opurum, Precious C., Amponsah, Jones Amo, Segbedzi, Kekeli Aku Lumor, Tetteh, Becky, Kumi-Ansah, Frederick, Mutungi, Joe K., Obodai, Evangeline, Amoako, Emmanuella, Agyemang, Seth, Ndam, Nicaise Tuikue, Ampofo, William Kwabena, Rayner, Julian C., Awandare, Gordon A., Paemka, Lily, Bediako, Yaw, and Quashie, Peter Kojo

Published
2022
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20. Population-based sero-epidemiological investigation of the dynamics of SARS-CoV-2 infections in the Greater Accra Region of Ghana

Author

Mensah, Benedicta Ayiedu, Ndong, Ignatius Cheng, Quashie, Peter Kojo, Guichet, Emilande, Abuaku, Benjamin, Effah-Baafi, Yaw, Tapela, Kesego, Asiedu, Kwame, Appiedu-Addo, Sekyibea Nana Ama, Obbeng, Louisa Baaba, Amponsah, Jones Amo, Kusi, Kwadwo Asamoah, Ofori, Michael, Ayouba, Ahidjo, Courtin, David, Tahar, Rachida, Delaporte, Eric, Awandare, Gordon, and Ndam, Nicaise Tuikue

Published
2022
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23. Predictors of COVID-19 epidemics in countries of the World Health Organization African Region

Author

Zhang, Feifei, Karamagi, Humphrey, Nsenga, Ngoy, Nanyunja, Miriam, Karinja, Miriam, Amanfo, Seth, Chase-Topping, Margo, Calder-Gerver, Giles, McGibbon, Miles, Huber, Alexandra, Wagner-Gamble, Tara, Guo, Chuan-Guo, Haynes, Samuel, Morrison, Alistair, Ferguson, Miranda, Awandare, Gordon A., Mutapi, Francisca, Yoti, Zabulon, Cabore, Joseph, Moeti, Matshidiso R., and Woolhouse, Mark E. J.

Published
2021
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24. Putative molecular markers of Plasmodium falciparum resistance to antimalarial drugs in malaria parasites from Ghana

Author

Matrevi, Sena Adzoa, primary, Adams, Tryphena, additional, Tandoh, Kwesi Zandoh, additional, Opoku-Agyeman, Philip, additional, Bruku, Selassie, additional, Ennuson, Nana Aba, additional, Apau-Danso, Paa Kwesi, additional, Fiagbedzi, Emmanuel, additional, Avornyo, Mary, additional, Myers, Charles James, additional, Futagbi, Joy, additional, Hagan, Oheneba Charles, additional, Abuaku, Benjamin, additional, Koram, Kwadwo Ansah, additional, Awandare, Gordon, additional, Quashie, Neils Ben, additional, and Duah-Quashie, Nancy Odurowah, additional

Published
2024
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25. Knowledge, attitude and perception towards COVID-19 among representative educated sub-Saharan Africans: A cross-sectional study during the exponential phase of the pandemic

Author

Udoakang, Aniefiok John, primary, Nganyewo, Nora Nghochuzie, additional, Djomkam Zune, Alexandra Lindsey, additional, Olwal, Charles Ochieng’, additional, Etim, Nsikak-Abasi Aniefiok, additional, Oboh, Mary Aigbiremo, additional, Tapela, Kesego, additional, Dzabeng, Francis, additional, Adadey, Samuel Mawuli, additional, Udoh, Agnes, additional, Koné, Mazo, additional, Mutungi, Joe Kimanthi, additional, Quashie, Peter Kojo, additional, Awandare, Gordon Akanzuwine, additional, and Paemka, Lily, additional

Published
2024
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28. Association of symptomatic upper respiratory tract infections with the alteration of the oropharyngeal microbiome in a cohort of school children in Côte d’Ivoire.

Author

Missa, Kouassi Firmin, Diallo, Kanny, Bla, Kouakou Brice, Tuo, Kolotioloman Jérémie, Thérèse Gboko, Kossia Debia, Tiémélé, Laurent-Simon, Ouattara, Allassane Foungoye, Gragnon, Biego Guillaume, Ngoi, Joyce Mwongeli, Wilkinson, Robert J., Awandare, Gordon A., and Bonfoh, Bassirou

Subjects
RESPIRATORY infections, SCHOOL children, HAEMOPHILUS influenzae, STREPTOCOCCUS pneumoniae, PATHOGENIC bacteria, NUCLEIC acids
Abstract

Introduction: The oropharyngeal microbiome plays an important role in protection against infectious agents when in balance. Despite use of vaccines and antibiotic therapy to prevent respiratory tract infections, they remain one of the major causes of mortality and morbidity in Low- and middleincome countries. Hence the need to explore other approaches to prevention by identifying microbial biomarkers that could be leveraged to modify the microbiota in order to enhance protection against pathogenic bacteria. The aim of this study was to analyze the oropharyngeal microbiome (OPM) of schoolchildren in Côte d’Ivoire presenting symptoms of upper respiratory tract infections (URTI) for better prevention strategy. Methods: Primary schools’ children in Korhogo (n = 37) and Abidjan (n = 39) were followed for six months with monthly oropharyngeal sampling. Clinical diagnostic of URT infection was performed and nucleic acid extracted from oropharyngeal swabs were used for 16S rRNA metagenomic analysis and RT-PCR. Results: The clinical examination of children’s throat in Abidjan and Korhogo identified respectively 17 (43.59%) and 15 (40.54%) participants with visible symptoms of URTIs, with 26 episodes of infection in Abidjan and 24 in Korhogo. Carriage of Haemophilus influenzae (12%), Streptococcus pneumoniae (6%) and SARS-CoV-2 (6%) was confirmed by PCR. A significant difference in alpha diversity was found between children colonized by S. pneumoniae and those that were not (p = 0.022). There was also a significant difference in alpha diversity between children colonised with H. influenzae and those who were not (p = 0.017). No significant difference was found for SARS-CoV-2. Sphingomonas, Ralstonia and Rothia were significantly enriched in non-carriers of S. pneumoniae; Actinobacillus was significantly enriched in non-carriers of H. influenzae; Actinobacillus and Porphyromonas were significantly enriched in non-carriers of SARS-CoV-2 (p < 0.001). Discussion: Nearly 40% of children showed clinical symptoms of infection not related to geographical location. The OPM showed an imbalance during H. influenzae and S. pneumoniae carriage. This study provides a baseline understanding of microbiome markers in URTIs in children for future research, to develop targeted interventions aimed at restoring the microbial balance and reducing the symptoms associated with RTIs. [ABSTRACT FROM AUTHOR]

Published
2024
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32. A complexPlasmodium falciparumcryptotype circulating at low frequency across the African continent

Author

Miotto, Olivo, primary, Amambua-Ngwa, Alfred, additional, Amenga-Etego, Lucas, additional, Abdel Hamid, Muzamil M, additional, Adam, Ishag, additional, Aninagyei, Enoch, additional, Apinjoh, Tobias, additional, Awandare, Gordon A, additional, Bejon, Philip, additional, Bertin, Gwladys I, additional, Bouyou-Akotet, Marielle, additional, Claessens, Antoine, additional, Conway, David J, additional, D’Alessandro, Umberto, additional, Diakite, Mahamadou, additional, Djimdé, Abdoulaye, additional, Dondorp, Arjen M, additional, Duffy, Patrick, additional, Fairhurst, Rick M, additional, Fanello, Caterina I, additional, Ghansah, Anita, additional, Ishengoma, Deus, additional, Lawniczak, Mara, additional, Maïga-Ascofaré, Oumou, additional, Auburn, Sarah, additional, Rosanas-Urgell, Anna, additional, Wasakul, Varanya, additional, White, Nina FD, additional, Almagro-Garcia, Jacob, additional, Pearson, Richard D, additional, Goncalves, Sonia, additional, Ariani, Cristina, additional, Bozdech, Zbynek, additional, Hamilton, William, additional, Simpson, Victoria, additional, and Kwiatkowski, Dominic P, additional

Published
2024
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33. Epidemiological overlaps in COVID-19 and malaria within healthcare and community settings of Southern Ghana

Author

Amegatcher, Gloria, primary, Acquah, Maame E, additional, Tetteh, Deborah, additional, Obeng, Rachael, additional, Debrah, Ethel, additional, Quist, Bridget, additional, Acquah-Jackson, Priscilla, additional, Boateng, Kyerewaa A, additional, Twieku, Gideon, additional, Armoo, Samuel, additional, Awandare, Gordon A, additional, Mosi, Lydia, additional, and Narh, Charles A, additional

Published
2023
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39. Upper Airway Epithelial Tissue Transcriptome Analysis Reveals Immune Signatures Associated with COVID-19 Severity in Ghanaians.

Author

Sandi, John Demby, Levy, Joshua I., Tapela, Kesego, Zeller, Mark, Yeboah, Joshua Afari, Saka, Daniel Frimpong, Grant, Donald S., Awandare, Gordon A., Quashie, Peter K., Andersen, Kristian G., and Paemka, Lily

Subjects
SARS-CoV-2, COVID-19, EPITHELIUM, TISSUE analysis, GHANAIANS
Abstract

The immunological signatures driving the severity of coronavirus disease 19 (COVID-19) in Ghanaians remain poorly understood. We performed bulk transcriptome sequencing of nasopharyngeal samples from severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-infected Ghanaians with mild and severe COVID-19, as well as healthy controls to characterize immune signatures at the primary SARS-CoV-2 infection site and identify drivers of disease severity. Generally, a heightened antiviral response was observed in SARS-CoV-2-infected Ghanaians compared with uninfected controls. COVID-19 severity was associated with immune suppression, overexpression of proinflammatory cytokines, including CRNN, IL1A, S100A7, and IL23A, and activation of pathways involved in keratinocyte proliferation. SAMD9L was among the differentially regulated interferon-stimulated genes in our mild and severe disease cohorts, suggesting that it may play a critical role in SARS-CoV-2 pathogenesis. By comparing our data with a publicly available dataset from a non-African (Indians) (GSE166530), an elevated expression of antiviral response-related genes was noted in COVID-19-infected Ghanaians. Overall, the study describes immune signatures driving COVID-19 severity in Ghanaians and identifies immune drivers that could serve as potential prognostic markers for future outbreaks or pandemics. It further provides important preliminary evidence suggesting differences in antiviral response at the upper respiratory interface in sub-Saharan Africans (Ghanaians) and non-Africans, which could be contributing to the differences in disease outcomes. Further studies using larger datasets from different populations will expand on these findings. [ABSTRACT FROM AUTHOR]

Published
2024
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40. The global transcriptome of Plasmodium falciparum mid-stage gametocytes (stages II–IV) appears largely conserved and gametocyte-specific gene expression patterns vary in clinical isolates

Author

Kengne-Ouafo, Jonas A., primary, Bah, Saikou Y., additional, Kemp, Alison, additional, Stewart, Lindsay, additional, Amenga-Etego, Lucas, additional, Deitsch, Kirk W., additional, Rayner, Julian C., additional, Billker, Oliver, additional, Binka, Fred N., additional, Sutherland, Colin J., additional, Awandare, Gordon A., additional, Urban, Britta C., additional, and Dinko, Bismarck, additional

Published
2023
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46. Development of an Affordable ELISA Targeting the SARS-CoV-2 Nucleocapsid and Its Application to Samples from the Ongoing COVID-19 Epidemic in Ghana

Author

Tapela, Kesego, primary, Opurum, Precious C., additional, Nuokpem, Franklin Y., additional, Tetteh, Becky, additional, Siaw, Godfred K., additional, Humbert, Maria V., additional, Tawiah-Eshun, Sylvia, additional, Barakisu, Anna Ibrahim, additional, Asiedu, Kwame, additional, Arhin, Samuel Kojo, additional, Manu, Aaron A., additional, Appiedu-Addo, Sekyibea N. A., additional, Obbeng, Louisa, additional, Quansah, Darius, additional, Languon, Sylvester, additional, Anyigba, Claudia, additional, Dosoo, Daniel, additional, Edu, Nelson K. O., additional, Oduro-Mensah, Daniel, additional, Ampofo, William, additional, Tagoe, Emmanuel, additional, Quaye, Osbourne, additional, Donkor, Irene Owusu, additional, Akorli, Jewelna, additional, Aniweh, Yaw, additional, Christodoulides, Myron, additional, Mutungi, Joe, additional, Bediako, Yaw, additional, Rayner, Julian C, additional, Awandare, Gordon A, additional, McCormick, Christopher J., additional, and Quashie, Peter Kojo, additional

Published
2023
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48. Sensitive Detection of Asymptomatic and Symptomatic Malaria with Seven Novel Parasite-Specific LAMP Assays and Translation for Use at Point-of-Care

Author

Malpartida-Cardenas, Kenny, primary, Moser, Nicolas, additional, Ansah, Felix, additional, Pennisi, Ivana, additional, Ahu Prah, Diana, additional, Amoah, Linda Eva, additional, Awandare, Gordon, additional, Hafalla, Julius Clemence R., additional, Cunnington, Aubrey, additional, Baum, Jake, additional, Rodriguez-Manzano, Jesus, additional, and Georgiou, Pantelis, additional

Published
2023
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