135,343 results on '"Ayala IN"'
Search Results
2. Characterization of Adiabatic Quantum-Flux-Parametrons in the MIT LL SFQ5ee+ Process
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Tolpygo, Sergey K., Golden, Evan B., Ayala, Christopher L., Schindler, Lieze, Johnston, Michael A., Parmar, Neel, and Yoshikawa, Nobuyuki
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Condensed Matter - Superconductivity ,Condensed Matter - Disordered Systems and Neural Networks ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Adiabatic quantum-flux-parametron (AQFP) logic is a proven energy-efficient superconductor technology for various applications. To address the scalability challenges, we investigated AQFP shift registers with the AQFP footprint area reduced by 25% with respect to prior work and with more than 2x denser overall designs obtained by eliminating the previously used free space between the AQFPs. We also investigated AQFP cells with different designs of flux trapping moats in the superconducting ground plane as well as compact AQFP cells that took advantage of the smaller feature sizes available in the new fabrication process, SFQ5ee+, at MIT Lincoln Laboratory. This new process features nine planarized Nb layers with a 0.25 $\mu$m minimum linewidth. The fabricated circuits were tested in a liquid He probe and in a closed-cycle cryocooler using a controlled cooling rate through the superconducting critical temperature. Using multiple thermal cycles, we investigated flux trapping in the dense AQFP shift registers as well as in the registers using the old (sparse) AQFP designs at two levels of the residual magnetic field, about 0.53 $\mu$T and about 1.2 $\mu$T. The sparse designs demonstrated 95% to almost 100% probability of operation after the cooldown and very wide operation margins, although the flux trapping probability was increasing with circuit complexities. The margins were similarly wide in the newer dense designs, but flux trapping probability that rendered the registers nonoperational was significantly, by an order of magnitude, higher in the denser circuits and was also very sensitive to the moats' shape and location. Our findings indicate that AQFP circuits are amendable to increasing the scale of integration and further densification, but a careful moat design and optimization are required to reduce flux trapping effects in the dense AQFP circuits., Comment: 5 pages, 10 figures, 2 tables, 18 references. Presented at Applied Superconductivity Conference, ASC2024, 1-6 September 2024, Salt Lake City, UT, USA
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- 2024
3. The Tangle Hypothesis
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Ayala, David and Francis, John
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Mathematics - Algebraic Topology ,Mathematics - Category Theory ,Mathematics - Geometric Topology ,Mathematics - Quantum Algebra ,Primary 57R56. Secondary 57R90, 18B30, 18D10 - Abstract
We introduce an $(\infty,1)$-category ${\sf Bord}_1^{\sf fr}(\mathbb{R}^n)$, the morphisms in which are framed tangles in $\mathbb{R}^n\times \mathbb{D}^1$. We prove that ${\sf Bord}_1^{\sf fr}(\mathbb{R}^n)$ has the universal mapping out property of the 1-dimensional Tangle Hypothesis of Baez--Dolan and Hopkins--Lurie: it is the rigid $\mathcal{E}_n$-monoidal $(\infty,1)$-category freely generated by a single object. Applying this theorem to a dualizable object of a braided monoidal $(\infty,1)$-category gives link invariants, generalizing the Reshetikhin--Turaev invariants., Comment: 103 pages, 12 figures
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- 2024
4. Quantum Sensing of Broadband Spin Dynamics and Magnon Transport in Antiferromagnets
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Melendez, Alex Lee, Das, Shekhar, Rodriguez, Francisco Ayala, Kao, I-Hsuan, Liu, Wenhao, Williams, Archibald J., Lv, Bing, Goldberger, Joshua, Chatterjee, Shubhayu, Singh, Simranjeet, and Hammel, P. Chris
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Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Optical detection of magnetic resonance using quantum spin sensors (QSS) provides a spatially local and sensitive technique to probe spin dynamics in magnets. However, its utility as a probe of antiferromagnetic resonance (AFMR), wherein the characteristic resonant frequencies substantially exceed the QSS probing frequency, remains an open question. Here, using the nitrogen-vacancy center in diamond as a QSS, we report the first experimental demonstration of optically detected AFMR in layered van der Waals antiferromagnets up to frequencies of 24 GHz, significantly higher than the sensor's spin resonance frequency of 2.87 GHz. To achieve this, we leverage the enhancement of the QSS spin relaxation rate due to low-frequency magnetic field fluctuations that arise from collective late-time dynamics of finite-wavevector magnons excited by the driven uniform AFMR mode. Using optically detected AFMR, we first characterize the temperature and magnetic field dependence on the AFMR modes, which shed light on the intrinsic exchange fields and magnetic anisotropies. Second, we exploit the highly localized sensitivity of the QSS to demonstrate efficient magnon transport over tens of micrometers. Finally, we find that optical detection efficiency in fact increases with increasing frequency, enabling broadband detection of magnetization dynamics. Our work showcases the dual capabilities of QSS as detectors of both high frequency magnetization dynamics and magnon transport, paving the way for understanding and controlling magnetism in Neel states in antiferromagnets.
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- 2024
5. Hydrodynamic limits and non-equilibrium fluctuations for the Symmetric Inclusion Process with long jumps
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Ayala, Mario and Zimmer, Johannes
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Mathematics - Probability - Abstract
We consider a d-dimensional symmetric inclusion process (SIP), where particles are allowed to jump arbitrarily far apart. We establish both the hydrodynamic limit and non-equilibrium fluctuations for the empirical measure of particles. With the help of self-duality and Mosco convergence of Dirichlet forms, we extend structural parallels between exclusion and inclusion dynamics from the short-range scenario to the long-range setting. The hydrodynamic equation for the symmetric inclusion process turns out to be of non-local type. At the level of fluctuations from the hydrodynamic limit, we demonstrate that the density fluctuation field converges to a time-dependent generalized Ornstein-Uhlenbeck process whose characteristics are again non-local., Comment: 33 pages
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- 2024
6. Spectral study of very high energy gamma rays from SS 433 with HAWC
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Alfaro, R., Alvarez, C., Arteaga-Velázquez, J. C., Rojas, D. Avila, Solares, H. A. Ayala, Babu, R., Belmont-Moreno, E., Caballero-Mora, K. S., Capistrán, T., Carramiñana, A., Casanova, S., Cotzomi, J., De la Fuente, E., Depaoli, D., Di Lalla, N., Hernandez, R. Diaz, Dingus, B. L ., DuVernois, M. A., Engel, K., Ergin, T., Espinoza, C ., Fan, K. L., Fang, K., Fraija, N., Fraija, S., García-González, J. A., Muñoz, A. González, González, M. M., Goodman, J. A., Groetsch, S., Harding, J. P., Hernández-Cadena, S., Herzog, I., Huang, D., Hueyotl-Zahuantitla, F., Hüntemeyer, P., Iriarte, A., Kaufmann, S., Lara, A ., Lee, W. H., Lee, J., de León, C., Vargas, H. León, Longinotti, A. L., Luis-Raya, G., Malone, K., Martínez-Castro, J., Matthews, J. A., Miranda-Romagnoli, P., Montes, J. A., Moreno, E., Mostafá, M., Nellen, L., Nisa, M. U ., Noriega-Papaqui, R ., Araujo, Y. Pérez, Pérez-Pérez, E. G., Rho, C. D., Rosa-González, D., Ruiz-Velasco, E ., Salazar, H., Sandoval, A., Schneider, M., Serna-Franco, J., Smith, A. J., Son, Y., Springer, R. W ., Tibolla, O., Tollefson, K., Torres, I., Torres-Escobedo, R., Turner, R., Ureña-Mena, F., Varela, E ., Villaseñor, L., Wang, X., Wang, Z., Watson, I. J., Yu, S ., Yun-Cárcamo, S., and Zhou, H.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Very-high-energy (0.1-100 TeV) gamma-ray emission was observed in HAWC data from the lobes of the microquasar SS 433, making them the first set of astrophysical jets that were resolved at TeV energies. In this work, we update the analysis of SS 433 using 2,565 days of data from the High Altitude Water Cherenkov (HAWC) observatory. Our analysis reports the detection of a point-like source in the east lobe at a significance of $6.6\,\sigma$ and in the west lobe at a significance of $8.2\,\sigma$. For each jet lobe, we localize the gamma-ray emission and identify a best-fit position. The locations are close to the X-ray emission sites "e1" and "w1" for the east and west lobes, respectively. We analyze the spectral energy distributions and find that the energy spectra of the lobes are consistent with a simple power-law $\text{d}N/\text{d}E\propto E^{\alpha}$ with $\alpha = -2.44^{+0.13+0.04}_{-0.12-0.04}$ and $\alpha = -2.35^{+0.12+0.03}_{-0.11-0.03}$ for the east and west lobes, respectively. The maximum energy of photons from the east and west lobes reaches 56 TeV and 123 TeV, respectively. We compare our observations to various models and conclude that the very-high-energy gamma-ray emission can be produced by a population of electrons that were efficiently accelerated.
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- 2024
7. A Debate-Driven Experiment on LLM Hallucinations and Accuracy
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Li, Ray, Bagade, Tanishka, Martinez, Kevin, Yasmin, Flora, Ayala, Grant, Lam, Michael, and Zhu, Kevin
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Computer Science - Computation and Language - Abstract
Large language models (LLMs) have achieved a degree of success in generating coherent and contextually relevant text, yet they remain prone to a significant challenge known as hallucination: producing information that is not substantiated by the input or external knowledge. Previous efforts to mitigate hallucinations have focused on techniques such as fine-tuning models on high-quality datasets, incorporating fact-checking mechanisms, and developing adversarial training methods. While these approaches have shown some promise, they often address the issue at the level of individual model outputs, leaving unexplored the effects of inter-model interactions on hallucination. This study investigates the phenomenon of hallucination in LLMs through a novel experimental framework where multiple instances of GPT-4o-Mini models engage in a debate-like interaction prompted with questions from the TruthfulQA dataset. One model is deliberately instructed to generate plausible but false answers while the other models are asked to respond truthfully. The experiment is designed to assess whether the introduction of misinformation by one model can challenge the truthful majority to better justify their reasoning, improving performance on the TruthfulQA benchmark. The findings suggest that inter-model interactions can offer valuable insights into improving the accuracy and robustness of LLM outputs, complementing existing mitigation strategies.
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- 2024
8. Ultra-High-Energy Gamma-Ray Bubble around Microquasar V4641 Sgr
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Alfaro, R., Alvarez, C., Arteaga-Velázquez, J. C., Rojas, D. Avila, Solares, H. A. Ayala, Babu, R., Belmont-Moreno, E., Caballero-Mora, K. S., Capistrán, T., Carramiñana, A., Casanova, S., Cotti, U., Cotzomi, J., de León, S. Coutiño, De la Fuente, E., Depaoli, D., Di Lalla, N., Hernandez, R. Diaz, Dingus, B. L., DuVernois, M. A., Durocher, M., Díaz-Vélez, J. C., Engel, K., Espinoza, C., Fan, K. L., Fang, K., Fraija, N., Fraija, S., García-González, J. A., Garfias, F., Muñoz, A. Gonzalez, González, M. M., Goodman, J. A., Groetsch, S., Harding, J. P., Herzog, I., Hinton, J., Huang, D., Hueyotl-Zahuantitla, F., Hüntemeyer, P., Iriarte, A., Joshi, V., Kaufmann, S., Kieda, D., de León, C., Lee, J., Vargas, H. León, Linnemann, J. T., Longinotti, A. L., Luis-Raya, G., Malone, K., Martinez, O., Martínez-Castro, J., Matthews, J. A., Miranda-Romagnoli, P., Morales-Soto, J. A., Moreno, E., Mostafá, M., Nayerhoda, A., Nellen, L., Newbold, M., Nisa, M. U., Noriega-Papaqui, R., Olivera-Nieto, L., Omodei, N., Osorio, M., Araujo, Y. Pérez, Pérez-Pérez, E. G., Rho, C. D., Rosa-González, D., Ruiz-Velasco, E., Salazar, H., Salazar-Gallegos, D., Sandoval, A., Schneider, M., Serna-Franco, J., Smith, A. J., Son, Y., Springer, R. W., Tibolla, O., Tollefson, K., Torres, I., Torres-Escobedo, R., Turner, R., Ureña-Mena, F., Varela, E., Villaseñor, L., Wang, X., Watson, I. J., Willox, E., Yun-Cárcamo, S., and Zhou, H.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Microquasars are laboratories for the study of jets of relativistic particles produced by accretion onto a spinning black hole. Microquasars are near enough to allow detailed imaging of spatial features across the multiwavelength spectrum. The recent extension of the spatial morphology of a microquasar, SS 433, to TeV gamma rays \cite{abeysekara2018very} localizes the acceleration of electrons at shocks in the jet far from the black hole \cite{hess2024ss433}. Here we report TeV gamma-ray emission from another microquasar, V4641~Sgr, which reveals particle acceleration at similar distances from the black hole as SS~433. Additionally, the gamma-ray spectrum of V4641 is among the hardest TeV spectra observed from any known gamma-ray source and is detected up to 200 TeV. Gamma rays are produced by particles, either electrons or hadrons, of higher energies. Because electrons lose energy more quickly the higher their energy, such a spectrum either very strongly constrains the electron production mechanism or points to the acceleration of high-energy hadrons. This observation suggests that large-scale jets from microquasars could be more common than previously expected and that microquasars could be a significant source of Galactic cosmic rays. high energy gamma-rays also provide unique constraints on the acceleration mechanisms of extra-Galactic cosmic rays postulated to be produced by the supermassive black holes and relativistic jets of quasars. The distance to quasars limits imaging studies due to insufficient angular resolution of gamma-rays and due to attenuation of the highest energy gamma-rays by the extragalactic background light.
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- 2024
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9. Towards unifying perturbative and Holographic Light-Front QCD via holomorphic coupling
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Ayala, Cesar and Cvetic, Gorazd
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High Energy Physics - Phenomenology - Abstract
We construct a QCD coupling ${\mathcal{A}}(Q^2)$ in the Effective Charge (ECH) scheme of the canonical part $d(Q^2)$ of the (inelastic) polarised Bjorken Sum Rule (BSR) ${\overline \Gamma}_1^{{\rm p-n}}(Q^2)$. In the perturbative domain, the coupling ${\mathcal{A}}(Q^2)$ practically coincides with the perturbative coupling $a(Q^2)$ [$\equiv \alpha_s(Q^2)/\pi$] in the four-loop ECH renormalisation scheme. In the deep infrared (IR) regime, ${\mathcal{A}}(Q^2)$ behaves as suggested by the Holographic Light-Front QCD up to the second derivative. Furthermore, in contrast to its perturbative counterpart $a(Q^2)$, the coupling ${\mathcal{A}}(Q^2)$ is holomorphic in the entire complex $Q^2$-plane with the exception of the negative semiaxis, reflecting the holomorphic properties of the BSR observable $d(Q^2)$ [or: ${\overline \Gamma}_1^{{\rm p-n}}(Q^2)$] as dictated by the general principles of the Quantum Field Theory. It turns out that the obtained coupling, used as ECH, reproduces quite well the experimental data for ${\overline \Gamma}_1^{{\rm p-n}}(Q^2)$ in the entire $N_f=3$ regime $0 < Q^2 \lesssim 5 \ {\rm GeV}^2$., Comment: 14 pages, 5 figures. arXiv admin note: text overlap with arXiv:2312.13134
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- 2024
10. On the origin of the peak of the sound velocity for isospin imbalanced strongly interacting matter
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Ayala, Alejandro, Lopes, Bruno S., Farias, Ricardo L. S., and Parra, Luis C.
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High Energy Physics - Phenomenology ,High Energy Physics - Lattice ,Nuclear Experiment ,Nuclear Theory - Abstract
We study the properties of a system composed of strongly interacting matter with an isospin imbalance, using as an effective description of QCD the two-flavor Linear Sigma Model with quarks. From the one-loop effective potential, including the two light quarks, pions and sigma contributions, and enforcing the restrictions imposed by chiral symmetry, we show that the development of an isospin condensate comes together with the emergence of a Goldstone mode that provides a constraint for the chiral and isospin condensates as a result of a non-trivial mixing between the charged pions and the sigma. We compute the thermodynamical quantities of interest and in particular the sound velocity squared, showing that it presents a maximum for an isospin chemical potential similar to the one reported by lattice QCD results and also with a similar height. Therefore, we attribute the origin of the peak of the sound velocity to the proper treatment of the Goldstone mode and to the non-trivial mixing of the charged pions and sigma in the isospin condensed phase., Comment: 7 pages, 2 figures
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- 2024
11. Intruding the sealed land: Unique forbidden beta decays at zero momentum transfer
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Seng, Chien-Yeah, Glick-Magid, Ayala, and Cirigliano, Vincenzo
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High Energy Physics - Phenomenology ,High Energy Physics - Experiment ,Nuclear Experiment ,Nuclear Theory - Abstract
We report the first study of the $\mathcal{O}(\alpha)$ structure-dependent electromagnetic radiative corrections to unique first-forbidden nuclear beta decays. We show that the insertion of angular momentum into the nuclear matrix element by the virtual/real photon exchange opens up the decay at vanishing nuclear recoil momentum which was forbidden at tree level, leading to a dramatic change in the decay spectrum not anticipated in existing studies. We discuss its implications for precision tests on the Standard Model and searches for new physics., Comment: 9 pages, 4 figures, 1 table (including supplementary material)
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- 2024
12. SWEET-Cat: A view on the planetary mass-radius relation
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Sousa, S. G., Adibekyan, V., Delgado-Mena, E., Santos, N. C., Rojas-Ayala, B., Barros, S. C., Demangeon, O. D. S., Hoyer, S., Israelian, G., Mortier, A., Soares, B. M. T., and Tsantaki, M.
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
SWEET-Cat (Stars With ExoplanETs Catalogue) was originally introduced in 2013, and since then, the number of confirmed exoplanets has increased significantly. A crucial step for a comprehensive understanding of these new worlds is the precise and homogeneous characterization of their host stars. We used a large number of high-resolution spectra to continue the addition of new stellar parameters for planet-host stars in SWEET-Cat following the new detection of exoplanets listed both at the Extrasolar Planets Encyclopedia and at the NASA exoplanet archive. We obtained high-resolution spectra for a significant number of these planet-host stars, either observed by our team or collected through public archives. For FGK stars, the spectroscopic stellar parameters were derived for the spectra following the same homogeneous process using ARES+MOOG as for the previous SWEET-Cat releases. The stellar properties are combined with the planet properties to study possible correlations that could shed more light into the star-planet connection studies. We increase the number of stars with homogeneous parameters by 232 ($\sim$ 25\% - from 959 to 1191). We then focus on the exoplanets with both mass and radius determined to review the mass-radius relation where we find consistent results with the ones previously reported in the literature. For the massive planets we also revisit the radius anomaly where we confirm a metallicity correlation for the radius anomaly already hinted in previous results., Comment: 8 pages, 5 figures, Accepted for A&A
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- 2024
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13. A Novel Optimal Transport-Based Approach for Interpolating Spectral Time Series: Paving the Way for Photometric Classification of Supernovae
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Ramirez, M., Pignata, G., Förster, Francisco, González-Gaitán, Santiago, Gutiérrez, Claudia P., Ayala, B., Cabrera-Vives, Guillermo, Catelan, Márcio, Arancibia, A. M. Muñoz, and Pineda-García, J.
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
This paper introduces a novel method for creating spectral time series, which can be used for generating synthetic light curves for photometric classification but also for applications like K-corrections and bolometric corrections. This approach is particularly valuable in the era of large astronomical surveys, where it can significantly enhance the analysis and understanding of an increasing number of SNe, even in the absence of extensive spectroscopic data. methods: By employing interpolations based on optimal transport theory, starting from a spectroscopic sequence, we derive weighted average spectra with high cadence. The weights incorporate an uncertainty factor for penalizing interpolations between spectra that show significant epoch differences and lead to a poor match between the synthetic and observed photometry. results: Our analysis reveals that even with phase difference of up to 40 days between pairs of spectra, optical transport can generate interpolated spectral time series that closely resemble the original ones. Synthetic photometry extracted from these spectral time series aligns well with observed photometry. The best results are achieved in the V band, with relative residuals of less than 10% for 87% and 84% of the data for type Ia and II, respectively. For the B, g, R and r bands, the relative residuals are between 65% and 87% within the previously mentioned 10% threshold for both classes. The worse results correspond to the i and I bands where, in the case, of SN~Ia the values drop to 53% and 42%, respectively. conclusions: We introduce a new method for constructing spectral time series for individual SNe starting from a sparse spectroscopic sequence, and demonstrate its capability to produce reliable light curves that can be used for photometric classification., Comment: Accepted for publication in A&A
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- 2024
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14. Strong Electron-Phonon Coupling and Lattice Dynamics in One-Dimensional [(CH3)2NH2]PbI3 Hybrid Perovskite
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Nonato, A., Rodríguez-Hernández, Juan S., Abreu, D. S., Soares, C. C. S., Gómez, Mayra A. P., García-Fernández, Alberto, Señarís-Rodríguez, María A., andújar, Manuel Sánchez, Ayala, A. P., Paschoal, C. W. A., and da Silva, Rosivaldo Xavier
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Condensed Matter - Materials Science ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Hybrid halide perovskites (HHPs) have attracted significant attention due to their remarkable optoelectronic properties that combine the advantages of low cost-effective fabrication methods of organic-inorganic materials. Notably, low-dimensional hybrid halide perovskites including two-dimensional (2D) layers and one-dimensional (1D) chains, are recognized for their superior stability and moisture resistance, making them highly appealing for practical applications. Particularly, DMAPbI3 has attracted attention due to other interesting behaviors and properties, such as thermally induced order-disorder processes, dielectric transition, and cooperative electric ordering of DMA dipole moments. In this paper, we investigated the interplay between low-temperature SPT undergone by the low-dimensional (1D) hybrid halide perovskite-like material DMAPbI3 and its optoelectronic properties. Our approach combines synchrotron X-ray powder diffraction, Raman spectroscopy, thermo-microscopy, differential scanning calorimetry (DSC), and photoluminescence (PL) techniques. Temperature-dependent Synchrotron powder diffraction and Raman Spectroscopy reveal that the modes associated with I-Pb-I and DMA+ ion play a crucial role in the order-disorder SPT in DMAPbI3. The reversible SPT modifies its optoelectronic properties, notably affecting its thermochromic behavior and PL emission. The origin of the PL phenomenon is associated to self-trapped excitons (STEs), which are allowed due to a strong electron-phonon coupling quantified by the Huang-Rhys factor (S = 97+-1). Notably, we identify the longitudinal optical (LO) phonon mode at 84 cm-1 which plays a significant role in electron-phonon interaction. Our results show these STEs not only intensify the PL spectra at lower temperatures but also induce a shift in the color emission, transforming it from a light orange-red to an intense bright strong red., Comment: 38 pages, 8 figures
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- 2024
15. A Mixed-Methods Study of Open-Source Software Maintainers On Vulnerability Management and Platform Security Features
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Ayala, Jessy, Tung, Yu-Jye, and Garcia, Joshua
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Computer Science - Software Engineering ,Computer Science - Cryptography and Security - Abstract
In open-source software (OSS), software vulnerabilities have significantly increased. Although researchers have investigated the perspectives of vulnerability reporters and OSS contributor security practices, understanding the perspectives of OSS maintainers on vulnerability management and platform security features is currently understudied. In this paper, we investigate the perspectives of OSS maintainers who maintain projects listed in the GitHub Advisory Database. We explore this area by conducting two studies: identifying aspects through a listing survey ($n_1=80$) and gathering insights from semi-structured interviews ($n_2=22$). Of the 37 identified aspects, we find that supply chain mistrust and lack of automation for vulnerability management are the most challenging, and barriers to adopting platform security features include a lack of awareness and the perception that they are not necessary. Surprisingly, we find that despite being previously vulnerable, some maintainers still allow public vulnerability reporting, or ignore reports altogether. Based on our findings, we discuss implications for OSS platforms and how the research community can better support OSS vulnerability management efforts.
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- 2024
16. A Deep Dive Into How Open-Source Project Maintainers Review and Resolve Bug Bounty Reports
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Ayala, Jessy, Ngo, Steven, and Garcia, Joshua
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Computer Science - Software Engineering ,Computer Science - Cryptography and Security - Abstract
Researchers have investigated the bug bounty ecosystem from the lens of platforms, programs, and bug hunters. Understanding the perspectives of bug bounty report reviewers, especially those who historically lack a security background and little to no funding for bug hunters, is currently understudied. In this paper, we primarily investigate the perspective of open-source software (OSS) maintainers who have used \texttt{huntr}, a bug bounty platform that pays bounties to bug hunters who find security bugs in GitHub projects and have had valid vulnerabilities patched as a result. We address this area by conducting three studies: identifying characteristics through a listing survey ($n_1=51$), their ranked importance with Likert-scale survey data ($n_2=90$), and conducting semi-structured interviews to dive deeper into real-world experiences ($n_3=17$). As a result, we categorize 40 identified characteristics into benefits, challenges, helpful features, and wanted features. We find that private disclosure and project visibility are the most important benefits, while hunters focused on money or CVEs and pressure to review are the most challenging to overcome. Surprisingly, lack of communication with bug hunters is the least challenging, and CVE creation support is the second-least helpful feature for OSS maintainers when reviewing bug bounty reports. We present recommendations to make the bug bounty review process more accommodating to open-source maintainers and identify areas for future work.
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- 2024
17. Deep intra-operative illumination calibration of hyperspectral cameras
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Baumann, Alexander, Ayala, Leonardo, Studier-Fischer, Alexander, Sellner, Jan, Özdemir, Berkin, Kowalewski, Karl-Friedrich, Ilic, Slobodan, Seidlitz, Silvia, and Maier-Hein, Lena
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Electrical Engineering and Systems Science - Image and Video Processing ,Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Machine Learning - Abstract
Hyperspectral imaging (HSI) is emerging as a promising novel imaging modality with various potential surgical applications. Currently available cameras, however, suffer from poor integration into the clinical workflow because they require the lights to be switched off, or the camera to be manually recalibrated as soon as lighting conditions change. Given this critical bottleneck, the contribution of this paper is threefold: (1) We demonstrate that dynamically changing lighting conditions in the operating room dramatically affect the performance of HSI applications, namely physiological parameter estimation, and surgical scene segmentation. (2) We propose a novel learning-based approach to automatically recalibrating hyperspectral images during surgery and show that it is sufficiently accurate to replace the tedious process of white reference-based recalibration. (3) Based on a total of 742 HSI cubes from a phantom, porcine models, and rats we show that our recalibration method not only outperforms previously proposed methods, but also generalizes across species, lighting conditions, and image processing tasks. Due to its simple workflow integration as well as high accuracy, speed, and generalization capabilities, our method could evolve as a central component in clinical surgical HSI., Comment: Oral at MICCAI 2024
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- 2024
18. Factors Contributing to the Development of Health-Promoting Schools, Applying Fullan's Triple Change Model -- A Qualitative Study
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Ayala Zak Yehuda and Orna Baron-Epel
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Objective: Schools and the education system are powerful tools for cultivating healthy lifestyles. This research focuses on characterising the factors contributing to the development of health-promoting schools in Israel, and understanding how schools can offer a framework for improving students' health. Fullan's triple change model with its focus on three phases in the change process in schools -- the initiation phase, the implementation phase and the institutionalisation phase -- served as a framework for analysis. Design and setting: This qualitative-constructivist study involved the analysis of data collected from 26 elementary school principals in Israel, 15 of whom belonged to the health promotion school network (HPSN) and 11 who did not. In addition, 10 health promotion leaders from within the schools were interviewed. Methods: Data collection took place by means of semi-structured interviews. in which the questions asked referred to the three phases identified in Fullan's process of change model. We analysed the data using thematic content analysis. Results: Each identified theme was associated with one of the phases proposed in Fullan's model of change. The "initiation" phase included collaboration with key stakeholders, principals' personal commitment, and dissemination of ideas through personal connections. The "implementation" phase included gaining access to appropriate tools and materials, action to deal with barriers to change, and the creation of a holistic health promotion environment. The "institutionalisation" phase included the development of administrative strategies such as adherence to routines, the inclusion of regular events in the school calendar, and the allocation of time frames for the activities undertaken. Conclusion: Fullan's model proved useful in analysing efforts to develop health-promoting schools. The model signalled the importance of using a structured approach throughout the institutionalisation phase in a manner attuned to the unique nature of the school. Alongside identifying key factors that support assimilation, it is crucial to assess their integration into the school culture. The school principal's role is critical throughout all the phases of the development process.
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- 2024
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19. School Middle Leaders' Transformational Leadership and Organizational Resilience: The Moderating Role of Academic Emphasis
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Ayala Zadok, Pascale Benoliel, and Chen Schechter
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This study examines how teachers' perceptions of academic emphasis moderate the relationship between their middle leaders' transformational leadership and organizational resilience subdimensions (principal organizational resilience and faculty organizational resilience). Academic emphasis in schools prioritizes academic excellence in teaching and is crucial in evaluating school effectiveness. The study used a two-source survey design with self-report data from 609 participants in 103 secondary schools in Israel. The results indicate that academic emphasis moderates the relationship between transformational leadership's sub-dimensions ("idealized influence," "inspirational motivation," "individualized consideration" and "intellectual stimulation") and principal organizational resilience but not faculty organizational resilience. The findings suggest that middle leaders can create a positive academic emphasis to optimize their transformational leadership's effects on organizational resilience. Theoretical and practical implications are discussed.
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- 2024
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20. Endpoints and Design for Clinical Trials in USH2A-Related Retinal Degeneration: Results and Recommendations From the RUSH2A Natural History Study
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Maguire, Maureen G, Birch, David G, Duncan, Jacque L, Ayala, Allison R, Ayton, Lauren N, Cheetham, Janet K, Cheng, Peiyao, Durham, Todd A, Ferris, Frederick L, Hoyng, Carel B, Huckfeldt, Rachel M, Jaffe, Glenn J, Kay, Christine, Lad, Eleonora M, Leroy, Bart P, Liang, Wendi, McDaniel, Lee S, Melia, Michele, Michaelides, Michel, Pennesi, Mark E, Sahel, José-Alain, Samarakoon, Lassana, and Group, on behalf of the REDI Working Group and the Foundation Fighting Blindness Clinical Consortium Investigator
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Biomedical and Clinical Sciences ,Ophthalmology and Optometry ,Clinical Trials and Supportive Activities ,Eye Disease and Disorders of Vision ,Clinical Research ,Neurodegenerative ,Neurosciences ,Eye ,Humans ,Visual Acuity ,Visual Fields ,Visual Field Tests ,Extracellular Matrix Proteins ,Female ,Male ,Adult ,Retinal Degeneration ,Middle Aged ,Tomography ,Optical Coherence ,Clinical Trials as Topic ,Young Adult ,Aged ,Research Design ,Adolescent ,Usher Syndromes ,REDI Working Group and the Foundation Fighting Blindness Clinical Consortium Investigator Group ,Biomedical Engineering ,Opthalmology and Optometry ,Ophthalmology and optometry - Abstract
PurposeTo evaluate functional and structural assessments as endpoints for clinical trials for USH2A-related retinal degeneration.MethodsPeople with biallelic disease-causing variants in USH2A, visual acuity ≥ 20/80, and visual field ≥ 10° diameter were enrolled in a 4-year, natural history study. Participants underwent static perimetry, microperimetry, visual acuity, fullfield stimulus testing (FST), and optical coherence tomography annually. Rates of change estimated from mixed-effects linear models and percentages of eyes with changes exceeding the coefficient of repeatability (CoR) or thresholds conforming with U.S. Food and Drug Administration (FDA) guidelines were evaluated.ResultsRates of change were generally more sensitive to change than proportions of eyes exceeding a threshold such as the CoR. Baseline ellipsoid zone area ≥ 3 mm2 was necessary to detect change. Mean sensitivity and volumetric hill of vision measures on static perimetry had similar properties and were the most sensitive to changes of the continuous measures. The highest 4-year proportions of eyes exceeding the CoR were from FST testing (47%) and microperimetry (32%). Specification of loci as functional transition points (FTPs) resulted in 45% (static perimetry) and 46% (microperimetry) at 4 years, meeting FDA guidelines for progression.ConclusionsRate of change of mean sensitivity on static perimetry was a sensitive perimetric continuous measure. Percentages of within-eye change were largest with FST testing and microperimetry. FTPs appear to be particularly sensitive to change. These results affect clinical trial design for USH2A-related retinal degeneration.Translational relevanceAnalyses of natural history data from the Rate of Progression in USH2A-Related Retinal Degeneration (RUSH2A) study can inform eligibility criteria and endpoints for clinical trials.
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- 2024
21. Isoform-specific C-terminal phosphorylation drives autoinhibition of Casein kinase 1.
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Harold, Rachel, Tulsian, Nikhil, Narasimamurthy, Rajesh, Yaitanes, Noelle, Ayala Hernandez, Maria, Lee, Hsiau-Wei, Crosby, Priya, Tripathi, Sarvind, Virshup, David, and Partch, Carrie
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circadian rhythms ,intrinsically disordered proteins ,kinase ,Phosphorylation ,Humans ,Casein Kinase Idelta ,Circadian Rhythm ,Animals ,Casein Kinase I ,HEK293 Cells ,Mice ,Protein Domains ,Mutation - Abstract
Casein kinase 1δ (CK1δ) controls essential biological processes including circadian rhythms and wingless-related integration site (Wnt) signaling, but how its activity is regulated is not well understood. CK1δ is inhibited by autophosphorylation of its intrinsically disordered C-terminal tail. Two CK1 splice variants, δ1 and δ2, are known to have very different effects on circadian rhythms. These variants differ only in the last 16 residues of the tail, referred to as the extreme C termini (XCT), but with marked changes in potential phosphorylation sites. Here, we test whether the XCT of these variants have different effects in autoinhibition of the kinase. Using NMR and hydrogen/deuterium exchange mass spectrometry, we show that the δ1 XCT is preferentially phosphorylated by the kinase and the δ1 tail makes more extensive interactions across the kinase domain. Mutation of δ1-specific XCT phosphorylation sites increases kinase activity both in vitro and in cells and leads to changes in the circadian period, similar to what is reported in vivo. Mechanistically, loss of the phosphorylation sites in XCT disrupts tail interaction with the kinase domain. δ1 autoinhibition relies on conserved anion-binding sites around the CK1 active site, demonstrating a common mode of product inhibition of CK1δ. These findings demonstrate how a phosphorylation cycle controls the activity of this essential kinase.
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- 2024
22. Feasibility and Acceptability of a Family-Based Telehealth Intervention for Families Impacted by the Child Welfare System: Formative Mixed Methods Evaluation
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Folk, Johanna B, Valencia-Ayala, Cynthia, Holloway, Evan D, Anvar, Sarah, Czopp, Alison, and Tolou-Shams, Marina
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Health Services and Systems ,Health Sciences ,Clinical Trials and Supportive Activities ,Prevention ,Mental Health ,Behavioral and Social Science ,Health Services ,Social Determinants of Health ,Telehealth ,Minority Health ,Brain Disorders ,Pediatric ,Health Disparities ,Clinical Research ,7.1 Individual care needs ,6.6 Psychological and behavioural ,3.1 Primary prevention interventions to modify behaviours or promote wellbeing ,Mental health ,Good Health and Well Being ,Humans ,Telemedicine ,Female ,Child ,Male ,Adolescent ,Feasibility Studies ,Child Welfare ,Adult ,Qualitative Research ,Focus Groups ,Family ,Caregivers ,adolescent health ,adverse childhood experiences ,affect management ,child welfare system ,family-based intervention ,formative evaluation ,substance misuse ,telehealth ,trauma exposure ,trauma-informed care ,Biomedical and clinical sciences ,Health sciences - Abstract
BackgroundDespite elevated rates of trauma exposure, substance misuse, mental health problems, and suicide, systems-impacted teens and their caregivers have limited access to empirically supported behavioral health services. Family-based interventions are the most effective for improving mental health, education, substance use, and delinquency outcomes, yet the familial and placement disruption that occurs during child welfare involvement can interfere with the delivery of family-based interventions.ObjectiveTo address this gap in access to services, we adapted an in-person, empirically supported, family-based affect management intervention using a trauma-informed lens to be delivered via telehealth to families impacted by the child welfare system (Family Telehealth Project). We describe the intervention adaptation process and an open trial to evaluate its feasibility, acceptability, and impact.MethodsAdaptations to the in-person, family-based affect management intervention were conducted iteratively with input from youth, caregivers, and systems partners. Through focus groups and collaborative meetings with systems partners, a caregiver-only version of the intervention was also developed. An open trial of the intervention was conducted to assess family perspectives of its acceptability and feasibility and inform further refinements prior to a larger-scale evaluation. Participants included English-speaking families involved in the child welfare system in the past 12 months with teens (aged 12-18 years). Caregivers were eligible to participate either individually (caregivers of origin, kinship caregivers, or foster parents; n=7) or with their teen (caregiver of origin only; n=6 dyads). Participants completed session feedback forms and surveys at pretreatment, posttreatment, and 3-month posttreatment time points. Qualitative exit interviews were conducted with a subset of participants (12/19, 63%) to further understand their experiences with the intervention.ResultsSession attendance was high, and both caregivers and teens reported high acceptability of clinicians and sessions on feedback forms. Families were comfortable with video technology, with very few (
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- 2024
23. Detection of Radio Emission from Super-flaring Solar-Type Stars in the VLA Sky Survey
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Davis, Ivey, Hallinan, Gregg, Ayala, Carlos, Dong, Dillon, and Myers, Steven
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Astrophysics - Solar and Stellar Astrophysics - Abstract
Solar-type stars have been observed to flare at optical wavelengths to energies much higher than observed for the Sun. To date, no counterparts have been observed at longer wavelengths. We have searched the the VLA Sky Survey (VLASS) for radio emission associated with a sample of 150 single, solar-type stars previously been observed to exhibit superflares in the Transiting Exoplanet Survey Satellite (TESS). Counterparts to six of these stars were present in VLASS as transient or highly variable radio sources. One of the stars is detected in all three epochs, exhibiting an unprecedented level of apparently persistent radio emission. The engine for this radio emission is unclear, but may be related to accretion, a binary companion, or the presence of large-scale magnetic field. Two stars show radio emission with >50 circular polarization fraction, indicating a coherent emission process likely being present. We find that the six VLASS-detected stars tend to have higher flare rates and higher flare energies of our TESS sample. This, in addition to the VLASS-detected stars adhering to the Gudel-Benz relation, suggest that the radio emission may be directly associated with superflares. These results confirm that the superflare phenomenon on solar-type stars extends to radio wavelengths, in this instance tracing particle acceleration. These data provide the first window on the luminosity function of radio superflares for solar-type stars and highlights the need for coordinated, multi-wavelength monitoring of such stars to fully illustrate the stellar flare-particle relation., Comment: 20 pages, 6 figures, 3 tables
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- 2024
24. Mechanical design concept version 2.0 for the miniBeBe subsystem of the Multi-Purpose Detector at the Nuclotron-based Ion Collider fAcility of the Joint Institute for Nuclear Research
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Herrera, M., Patiño, M. E., Alvarado, Mauricio, Maldonado, Ivonne, Andreev, Denis, Ayala, Alejandro, Bietenholz, Wolfgang, Ceballos, César, Cuáutle, Eleazar, Domínguez, Isabel, Hernández, L. A., Luna, Israel, Lygdenova, Tuyana, Martínez-Torres, Pablo, Raya, Alfredo, Sáenz-Trujillo, Ulises, Tejeda-Yeomans, M. E., and Tinoco-Santillán, Galileo
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Physics - Instrumentation and Detectors - Abstract
We present the design of the mechanical structure of the miniBeBe detector, a subsystem of the Multi-Purpose Detector, soon to enter into operation at the Nuclotron based Ion Collider fAcility of the Joint Institute for Nuclear Research. The miniBeBe detector was designed and is currently being developed by the MexNICA Collaboration to contribute to the level-zero trigger of the Time of Flight. The mechanical structure meets the requirements of minimizing the material budget and be free of ferromagnetic materials, without compromising its robustness. The design also allows easy module replacement for maintenance and overall removal at the end of the first stage of the experiment, without affecting the rest of the subsystems, to leave room for the installation of the Inner Tracking System. In addition, a Finite Element Method analysis of the mechanical components under load was performed. Based on this analysis, it was determined that the design meets the space constraints within the Multi-Purpose Detector, as well as a deformation of less than 1 mm with overall stress of less than 2 MPa, such that no material used in the design is at risk of mechanical failure during operation. A cooling system heat transfer analysis was performed showing that the detector Silicon Photo-Multipliers can be kept within a temperature range of 19$^{\circ}$C to 23$^{\circ}$C, which is adequate for their optimal performance., Comment: 15 pages, 13 figures, 6 tables
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- 2024
25. What Can Interactive Visualization do for Participatory Budgeting in Chicago?
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Kale, Alex, Liu, Danni, Ayala, Maria Gabriela, Schwab, Harper, and McNutt, Andrew
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Computer Science - Human-Computer Interaction - Abstract
Participatory budgeting (PB) is a democratic approach to allocating municipal spending that has been adopted in many places in recent years, including in Chicago. Current PB voting resembles a ballot where residents are asked which municipal projects, such as school improvements and road repairs, to fund with a limited budget. In this work, we ask how interactive visualization can benefit PB by conducting a design probe-based interview study (N=13) with policy workers and academics with expertise in PB, urban planning, and civic HCI. Our probe explores how graphical elicitation of voter preferences and a dashboard of voting statistics can be incorporated into a realistic PB tool. Through qualitative analysis, we find that visualization creates opportunities for city government to set expectations about budget constraints while also granting their constituents greater freedom to articulate a wider range of preferences. However, using visualization to provide transparency about PB requires efforts to mitigate potential access barriers and mistrust. We call for more visualization professionals to help build civic capacity by working in and studying political systems.
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- 2024
26. Testing the Molecular Cloud Paradigm for Ultra-High-Energy Gamma Ray Emission from the Direction of SNR G106.3+2.7
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Alfaro, R., Alvarez, C., Arteaga-Velázquez, J. C., Rojas, D. Avila, Solares, H. A. Ayala, Babu, R., Belmont-Moreno, E., Bernal, A., Caballero-Mora, K. S., Capistrán, T., Carramiñana, A., Casanova, S., Cotti, U., Cotzomi, J., de León, S. Coutiño, De la Fuente, E., de León, C., Depaoli, D., Desiati, P., Di Lalla, N., Hernandez, R. Diaz, Dingus, B. L., DuVernois, M. A., Engel, K., Ergin, T., Espinoza, C., Fan, K. L., Fang, K., Fraija, N., Fraija, S., García-González, J. A., Garfias, F., González, M. M., Goodman, J. A., Groetsch, S., Harding, J. P., Hernández-Cadena, S., Herzog, I., Hinton, J., Huang, D., Hueyotl-Zahuantitla, F., Humensky, T. B., Hüntemeyer, P., Kaufmann, S., Kieda, D., Lee, W. H., Lee, J., Vargas, H. León, Linnemann, J. T., Longinotti, A. L., Luis-Raya, G., Malone, K., Martinez, O., Martínez-Castro, J., Matthews, J. A., Miranda-Romagnoli, P., Montes, J. A., Moreno, E., Mostafá, M., Nellen, L., Nisa, M. U., Olivera-Nieto, L., Omodei, N., Araujo, Y. Pérez, Pérez-Pérez, E. G., Rho, C. D., Rosa-González, D., Salazar, H., Salazar-Gallegos, D., Sandoval, A., Schneider, M., Serna-Franco, J., Smith, A. J., Son, Y., Springer, R. W., Tibolla, O., Tollefson, K., Torres, I., Torres-Escobedo, R., Turner, R., Ureña-Mena, F., Varela, E., Villaseñor, L., Wang, X., Wang, Z., Watson, I. J., Willox, E., Yu, S., Yun-Cárcamo, S., and Zhou, H.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Supernova remnants (SNRs) are believed to be capable of accelerating cosmic rays (CRs) to PeV energies. SNR G106.3+2.7 is a prime PeVatron candidate. It is formed by a head region, where the pulsar J2229+6114 and its boomerang-shaped pulsar wind nebula are located, and a tail region containing SN ejecta. The lack of observed gamma ray emission from the two regions of this SNR has made it difficult to assess which region would be responsible for the PeV CRs. We aim to characterize the very-high-energy (VHE, 0.1-100 TeV) gamma ray emission from SNR G106.3+2.7 by determining the morphology and spectral energy distribution of the region. This is accomplished using 2565 days of data and improved reconstruction algorithms from the HAWC Observatory. We also explore possible gamma ray production mechanisms for different energy ranges. Using a multi-source fitting procedure based on a maximum-likelihood estimation method, we evaluate the complex nature of this region. We determine the morphology, spectrum, and energy range for the source found in the region. Molecular cloud information is also used to create a template and evaluate the HAWC gamma ray spectral properties at ultra-high-energies (UHE, >56 TeV). This will help probe the hadronic nature of the highest-energy emission from the region. We resolve one extended source coincident with all other gamma ray observations of the region. The emission reaches above 100~TeV and its preferred log-parabola shape in the spectrum shows a flux peak in the TeV range. The molecular cloud template fit on the higher energy data reveals that the SNR's energy budget is fully capable of producing a purely hadronic source for UHE gamma rays.
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- 2024
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27. Influence of magnetic field-induced anisotropic gluon pressure during pre-equilibrium in heavy-ion collisions: A faster road towards isotropization
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Ayala, A. and Mizher, A.
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High Energy Physics - Phenomenology ,High Energy Physics - Theory ,Nuclear Theory - Abstract
Magnetic fields of a large intensity can be generated in peripheral high-energy heavy-ion collisions. Although their intensity drops fast and, moreover, it is not clear whether these fields last long enough to induce a magnetization during the quark-gluon plasma phase, most of the models and simulations predict a significant intensity that lasts up to proper times of order 1 fm after the beginning of the reaction, which is a typical time for the hydrodynamical phase to start. This interval of time is referred to as the pre-equilibrium stage. The evolution of the reaction during pre-equilibrium is thus likely to be influenced by these fields. In this work we adopt a strong field approximation to study the effects of the magnetic field-induced anisotropy on the gluon pressure. We include this anisotropy within the description obtained by means of Effective Kinetic Theory and explore the consequences to reach isotropization at proper times of order 1 fm. We show that when including the magnetic field effects, isotropization is achieved faster., Comment: 5 pages, 5 figures
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- 2024
28. Observation of the Galactic Center PeVatron Beyond 100 TeV with HAWC
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Albert, A., Alfaro, R., Alvarez, C., Andrés, A., Arteaga-Velázquez, J. C., Rojas, D. Avila, Solares, H. A. Ayala, Babu, R., Belmont-Moreno, E., Bernal, A., Caballero-Mora, K. S., Capistrán, T., Carramiñana, A., Casanova, S., Cotti, U., Cotzomi, J., de León, S. Coutiño, De la Fuente, E., de León, C., Depaoli, D., Di Lalla, N., Hernandez, R. Diaz, Dingus, B. L., DuVernois, M. A., Díaz-Vélez, J. C., Engel, K., Ergin, T., Espinoza, C., Fan, K. L., Fang, K., Fraija, N., Fraija, S., García-González, J. A., Garfias, F., Goksu, H., González, M. M., Goodman, J. A., Groetsch, S., Harding, J. P., Hernández-Cadena, S., Herzog, I., Hinton, J., Huang, D., Hueyotl-Zahuantitla, F., Humensky, T. B., Hüntemeyer, P., Iriarte, A., Kaufmann, S., Kieda, D., Lara, A., Lee, W. H., Lee, J., Vargas, H. León, Linnemann, J. T., Longinotti, A. L., Luis-Raya, G., Malone, K., Martinez, O., Martínez-Castro, J., Matthews, J. A., Miranda-Romagnoli, P., Montes, J. A., Morales-Soto, J. A., Moreno, E., Mostafá, M., Najafi, M., Nellen, L., Newbold, M., Nisa, M. U., Noriega-Papaqui, R., Olivera-Nieto, L., Omodei, N., Osorio-Archila, M., Araujo, Y. Pérez, Pérez-Pérez, E. G., Rho, C. D., Rosa-González, D., Ruiz-Velasco, E., Salazar, H., Salazar-Gallegos, D., Sandoval, A., Schneider, M., Schwefer, G., Serna-Franco, J., Smith, A. J., Son, Y., Springer, R. W., Tibolla, O., Tollefson, K., Torres, I., Torres-Escobedo, R., Turner, R., Ureña-Mena, F., Varela, E., Wang, X., Wang, Z., Watson, I. J., Willox, E., Wu, H., Yu, S., Yun-Cárcamo, S., and Zhou, H.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We report an observation of ultra-high energy (UHE) gamma rays from the Galactic Center region, using seven years of data collected by the High-Altitude Water Cherenkov (HAWC) Observatory. The HAWC data are best described as a point-like source (HAWC J1746-2856) with a power-law spectrum ($\mathrm{d}N/\mathrm{d}E=\phi(E/26 \,\text{TeV})^{\gamma}$), where $\gamma=-2.88 \pm 0.15_{\text{stat}} - 0.1_{\text{sys}} $ and $\phi=1.5 \times 10^{-15}$ (TeV cm$^{2}$s)$^{-1}$ $\pm\, 0.3_{\text{stat}}\,^{+0.08_{\text{sys}}}_{-0.13_{\text{sys}}}$ extending from 6 to 114 TeV. We find no evidence of a spectral cutoff up to $100$ TeV using HAWC data. Two known point-like gamma-ray sources are spatially coincident with the HAWC gamma-ray excess: Sgr A$^{*}$ (HESS J1745-290) and the Arc (HESS J1746-285). We subtract the known flux contribution of these point sources from the measured flux of HAWC J1746-2856 to exclude their contamination and show that the excess observed by HAWC remains significant ($>$5$\sigma$) with the spectrum extending to $>$100 TeV. Our result supports that these detected UHE gamma rays can originate via hadronic interaction of PeV cosmic-ray protons with the dense ambient gas and confirms the presence of a proton PeVatron at the Galactic Center.
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- 2024
29. Analysis of the Emission and Morphology of the Pulsar Wind Nebula Candidate HAWC J2031+415
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Alfaro, R., Alvarez, C., Arteaga-Velázquez, J. C., Rojas, D. Avila, Solares, H. A. Ayala, Babu, R., Belmont-Moreno, E., Caballero-Mora, K. S., Capistrán, T., Carramiñana, A., Casanova, S., Cotti, U., Cotzomi, J., de León, S. Coutiño, De la Fuente, E., de León, C., Depaoli, D., Di Lalla, N., Hernandez, R. Diaz, Dingus, B. L., DuVernois, M. A., Díaz-Vélez, J. C., Engel, K., Ergin, T., Espinoza, C., Fan, K. L., Fraija, N., García-González, J. A., González, M. M., Goodman, J. A., Groetsch, S., Harding, J. P., Hernández-Cadena, S., Herzog, I., Huang, D., Hueyotl-Zahuantitla, F., Hüntemeyer, P., Iriarte, A., Kaufmann, S., Lee, J., Vargas, H. León, Longinotti, A. L., Luis-Raya, G., Malone, K., Martínez-Castro, J., Matthews, J. A., Miranda-Romagnoli, P., Montes, . A., Moreno, E., Mostafá, M., Nellen, L., Newbold, M., Nisa, M. U., Noriega-Papaqui, R., Araujo, Y. Pérez, Pérez-Pérez, E. G., Rho, C. D., Rosa-González, D., Ruiz-Velasco, E., Salazar, H., Salazar-Gallegos, D., Sandoval, A., Schneider, M., Serna-Franco, J., Smith, A. J., Son, Y., Springer, R. W., Tibolla, O., Tollefson, K., Torres, I., Torres-Escobedo, R., Turner, R., Ureña-Mena, F., Varela, E., Villaseñor, L., Wang, X., Wang, Zhen, Watson, I. J., Yu, S., Yun-Cárcamo, S., and Zhou, H.
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Astrophysics - High Energy Astrophysical Phenomena ,High Energy Physics - Experiment - Abstract
The first TeV gamma-ray source with no lower energy counterparts, TeV J2032+4130, was discovered by HEGRA. It appears in the third HAWC catalog as 3HWC J2031+415 and it is a bright TeV gamma-ray source whose emission has previously been resolved as 2 sources: HAWC J2031+415 and HAWC J2030+409. While HAWC J2030+409 has since been associated with the \emph{Fermi-LAT} Cygnus Cocoon, no such association for HAWC J2031+415 has yet been found. In this work, we investigate the spectrum and energy-dependent morphology of HAWC J2031+415. We associate HAWC J2031+415 with the pulsar PSR J2032+4127 and perform a combined multi-wavelength analysis using radio, X-ray, and $\gamma$-ray emission. We conclude that HAWC J2031+415 and, by extension, TeV J2032+4130 are most probably a pulsar wind nebula (PWN) powered by PSR J2032+4127.
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- 2024
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30. Mosco convergence of independent particles and applications to particle systems with self-duality
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Ayala, Mario
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Mathematics - Probability - Abstract
We consider a sequence of Markov processes $\lbrace X_t^n \mid n \in \mathbb{N} \rbrace$ with Dirichlet forms converging in the Mosco sense of Kuwae and Shioya to the Dirichlet form associated with a Markov process $X_t$. Under this assumption, we demonstrate that for any natural number $k$, the sequence of Dirichlet forms corresponding to the Markov processes generated by $k$ independent copies of $\lbrace X_t^n \mid n \in \mathbb{N} \rbrace$ also converges. As expected, the limit of this convergence is the Dirichlet form associated with $k$ independent copies of the process $X_t$. We provide applications of this result in the context of interacting particle systems with Markov moment duality.
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- 2024
31. Two-gluon one-photon vertex in a magnetic field and its explicit one-loop approximation in the intermediate field strength regime
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Ayala, Alejandro, Bernal-Langarica, Santiago, Jaber-Urquiza, Jorge, and Medina-Serna, José Jorge
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High Energy Physics - Phenomenology ,Nuclear Theory - Abstract
We find the general structure for the two-gluon one-photon vertex in the presence of a constant magnetic field. We show that, when accounting for the symmetries satisfied by the strong and electromagnetic interactions under parity, charge conjugation and gluon interchange, and for gluons and photons on mass-shell, there exist only three possible tensor structures that span the vertex. These correspond to external products of the polarization vectors for each of the particles in the vertex. We also explicitly compute the one-loop approximation to this vertex in the intermediate field strength regime, which is the most appropriate one to describe possible effects of the presence of a magnetic field to enhance photon emission during pre-equilibrium in peripheral relativistic heavy-ion collisions. We show that the most favored direction for the photon to propagate is in the plane transverse to the field, which is consistent with a positive contribution to $\nu_2$ and may help to understand the larger than expected elliptic flow coefficient measured in this kind of reactions., Comment: Key words: magnetic fields, heavy-ion collisions, photon puzzle, gluon-photon vertex
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- 2024
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32. Sparse Sub-gaussian Random Projections for Semidefinite Programming Relaxations
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Guedes-Ayala, Monse, Poirion, Pierre-Louis, Schewe, Lars, and Takeda, Akiko
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Mathematics - Optimization and Control - Abstract
Random projection, a dimensionality reduction technique, has been found useful in recent years for reducing the size of optimization problems. In this paper, we explore the use of sparse sub-gaussian random projections to approximate semidefinite programming (SDP) problems by reducing the size of matrix variables, thereby solving the original problem with much less computational effort. We provide some theoretical bounds on the quality of the projection in terms of feasibility and optimality that explicitly depend on the sparsity parameter of the projector. We investigate the performance of the approach for semidefinite relaxations appearing in polynomial optimization, with a focus on combinatorial optimization problems. In particular, we apply our method to the semidefinite relaxations of MAXCUT and MAX-2-SAT. We show that for large unweighted graphs, we can obtain a good bound by solving a projection of the semidefinite relaxation of MAXCUT. We also explore how to apply our method to find the stability number of four classes of imperfect graphs by solving a projection of the second level of the Lasserre Hierarchy. Overall, our computational experiments show that semidefinite programming problems appearing as relaxations of combinatorial optimization problems can be approximately solved using random projections as long as the number of constraints is not too large.
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- 2024
33. TelecomRAG: Taming Telecom Standards with Retrieval Augmented Generation and LLMs
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Yilma, Girma M., Ayala-Romero, Jose A., Garcia-Saavedra, Andres, and Costa-Perez, Xavier
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Computer Science - Networking and Internet Architecture ,Computer Science - Machine Learning - Abstract
Large Language Models (LLMs) have immense potential to transform the telecommunications industry. They could help professionals understand complex standards, generate code, and accelerate development. However, traditional LLMs struggle with the precision and source verification essential for telecom work. To address this, specialized LLM-based solutions tailored to telecommunication standards are needed. Retrieval-augmented generation (RAG) offers a way to create precise, fact-based answers. This paper proposes TelecomRAG, a framework for a Telecommunication Standards Assistant that provides accurate, detailed, and verifiable responses. Our implementation, using a knowledge base built from 3GPP Release 16 and Release 18 specification documents, demonstrates how this assistant surpasses generic LLMs, offering superior accuracy, technical depth, and verifiability, and thus significant value to the telecommunications field., Comment: 7 pages, 2 figures, 3 tables
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- 2024
34. The PLATO Mission
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Rauer, Heike, Aerts, Conny, Cabrera, Juan, Deleuil, Magali, Erikson, Anders, Gizon, Laurent, Goupil, Mariejo, Heras, Ana, Lorenzo-Alvarez, Jose, Marliani, Filippo, Martin-Garcia, Cesar, Mas-Hesse, J. Miguel, O'Rourke, Laurence, Osborn, Hugh, Pagano, Isabella, Piotto, Giampaolo, Pollacco, Don, Ragazzoni, Roberto, Ramsay, Gavin, Udry, Stéphane, Appourchaux, Thierry, Benz, Willy, Brandeker, Alexis, Güdel, Manuel, Janot-Pacheco, Eduardo, Kabath, Petr, Kjeldsen, Hans, Min, Michiel, Santos, Nuno, Smith, Alan, Suarez, Juan-Carlos, Werner, Stephanie C., Aboudan, Alessio, Abreu, Manuel, Acuña, Lorena, Adams, Moritz, Adibekyan, Vardan, Affer, Laura, Agneray, François, Agnor, Craig, Børsen-Koch, Victor Aguirre, Ahmed, Saad, Aigrain, Suzanne, Al-Bahlawan, Ashraf, Gil, M de los Angeles Alcacera, Alei, Eleonora, Alencar, Silvia, Alexander, Richard, Alfonso-Garzón, Julia, Alibert, Yann, Prieto, Carlos Allende, Almeida, Leonardo, Sobrino, Roi Alonso, Altavilla, Giuseppe, Althaus, Christian, Trujillo, Luis Alonso Alvarez, Amarsi, Anish, Eiff, Matthias Ammler-von, Amôres, Eduardo, Andrade, Laerte, Antoniadis-Karnavas, Alexandros, António, Carlos, del Moral, Beatriz Aparicio, Appolloni, Matteo, Arena, Claudio, Armstrong, David, Aliaga, Jose Aroca, Asplund, Martin, Audenaert, Jeroen, Auricchio, Natalia, Avelino, Pedro, Baeke, Ann, Baillié, Kevin, Balado, Ana, Balestra, Andrea, Ball, Warrick, Ballans, Herve, Ballot, Jerome, Barban, Caroline, Barbary, Gaële, Barbieri, Mauro, Forteza, Sebastià Barceló, Barker, Adrian, Barklem, Paul, Barnes, Sydney, Navascues, David Barrado, Barragan, Oscar, Baruteau, Clément, Basu, Sarbani, Baudin, Frederic, Baumeister, Philipp, Bayliss, Daniel, Bazot, Michael, Beck, Paul G., Bedding, Tim, Belkacem, Kevin, Bellinger, Earl, Benatti, Serena, Benomar, Othman, Bérard, Diane, Bergemann, Maria, Bergomi, Maria, Bernardo, Pierre, Biazzo, Katia, Bignamini, Andrea, Bigot, Lionel, Billot, Nicolas, Binet, Martin, Biondi, David, Biondi, Federico, Birch, Aaron C., Bitsch, Bertram, Ceballos, Paz Victoria Bluhm, Bódi, Attila, Bognár, Zsófia, Boisse, Isabelle, Bolmont, Emeline, Bonanno, Alfio, Bonavita, Mariangela, Bonfanti, Andrea, Bonfils, Xavier, Bonito, Rosaria, Bonomo, Aldo Stefano, Börner, Anko, Saikia, Sudeshna Boro, Martín, Elisa Borreguero, Borsa, Francesco, Borsato, Luca, Bossini, Diego, Bouchy, Francois, Boué, Gwenaël, Boufleur, Rodrigo, Boumier, Patrick, Bourrier, Vincent, Bowman, Dominic M., Bozzo, Enrico, Bradley, Louisa, Bray, John, Bressan, Alessandro, Breton, Sylvain, Brienza, Daniele, Brito, Ana, Brogi, Matteo, Brown, Beverly, Brown, David, Brun, Allan Sacha, Bruno, Giovanni, Bruns, Michael, Buchhave, Lars A., Bugnet, Lisa, Buldgen, Gaël, Burgess, Patrick, Busatta, Andrea, Busso, Giorgia, Buzasi, Derek, Caballero, José A., Cabral, Alexandre, Calderone, Flavia, Cameron, Robert, Cameron, Andrew, Campante, Tiago, Martins, Bruno Leonardo Canto, Cara, Christophe, Carone, Ludmila, Carrasco, Josep Manel, Casagrande, Luca, Casewell, Sarah L., Cassisi, Santi, Castellani, Marco, Castro, Matthieu, Catala, Claude, Fernández, Irene Catalán, Catelan, Márcio, Cegla, Heather, Cerruti, Chiara, Cessa, Virginie, Chadid, Merieme, Chaplin, William, Charpinet, Stephane, Chiappini, Cristina, Chiarucci, Simone, Chiavassa, Andrea, Chinellato, Simonetta, Chirulli, Giovanni, Christensen-Dalsgaard, Jorgen, Church, Ross, Claret, Antonio, Clarke, Cathie, Claudi, Riccardo, Clermont, Lionel, Coelho, Hugo, Coelho, Joao, Cogato, Fabrizio, Colomé, Josep, Condamin, Mathieu, Conseil, Simon, Corbard, Thierry, Correia, Alexandre C. M., Corsaro, Enrico, Cosentino, Rosario, Costes, Jean, Cottinelli, Andrea, Covone, Giovanni, Creevey, Orlagh L., Crida, Aurelien, Csizmadia, Szilard, Cunha, Margarida, Curry, Patrick, da Costa, Jefferson, da Silva, Francys, Dalal, Shweta, Damasso, Mario, Damiani, Cilia, Damiani, Francesco, Chagas, Maria Liduina das, Davies, Melvyn, Davies, Guy, Davies, Ben, Davison, Gary, de Almeida, Leandro, de Angeli, Francesca, de Barros, Susana Cristina Cabral, Leão, Izan de Castro, de Freitas, Daniel Brito, de Freitas, Marcia Cristina, De Martino, Domitilla, de Medeiros, José Renan, de Paula, Luiz Alberto, de Plaa, Jelle, De Ridder, Joris, Deal, Morgan, Decin, Leen, Deeg, Hans, Degl'Innocenti, Scilla, Deheuvels, Sebastien, del Burgo, Carlos, Del Sordo, Fabio, Delgado-Mena, Elisa, Demangeon, Olivier, Denk, Tilmann, Derekas, Aliz, Desidera, Silvano, Dexet, Marc, Di Criscienzo, Marcella, Di Giorgio, Anna Maria, Di Mauro, Maria Pia, Rial, Federico Jose Diaz, Díaz-García, José-Javier, Dima, Marco, Dinuzzi, Giacomo, Dionatos, Odysseas, Distefano, Elisa, Nascimento Jr., Jose-Dias do, Domingo, Albert, D'Orazi, Valentina, Dorn, Caroline, Doyle, Lauren, Duarte, Elena, Ducellier, Florent, Dumaye, Luc, Dumusque, Xavier, Dupret, Marc-Antoine, Eggenberger, Patrick, Ehrenreich, David, Eigmüller, Philipp, Eising, Johannes, Emilio, Marcelo, Eriksson, Kjell, Ermocida, Marco, Giribaldi, Riano Isidoro Escate, Eschen, Yoshi, Estrela, Inês, Evans, Dafydd Wyn, Fabbian, Damian, Fabrizio, Michele, Faria, João Pedro, Farina, Maria, Farinato, Jacopo, Feliz, Dax, Feltzing, Sofia, Fenouillet, Thomas, Ferrari, Lorenza, Ferraz-Mello, Sylvio, Fialho, Fabio, Fienga, Agnes, Figueira, Pedro, Fiori, Laura, Flaccomio, Ettore, Focardi, Mauro, Foley, Steve, Fontignie, Jean, Ford, Dominic, Fornazier, Karin, Forveille, Thierry, Fossati, Luca, Franca, Rodrigo de Marca, da Silva, Lucas Franco, Frasca, Antonio, Fridlund, Malcolm, Furlan, Marco, Gabler, Sarah-Maria, Gaido, Marco, Gallagher, Andrew, Galli, Emanuele, Garcia, Rafael A., Hernández, Antonio García, Munoz, Antonio Garcia, García-Vázquez, Hugo, Haba, Rafael Garrido, Gaulme, Patrick, Gauthier, Nicolas, Gehan, Charlotte, Gent, Matthew, Georgieva, Iskra, Ghigo, Mauro, Giana, Edoardo, Gill, Samuel, Girardi, Leo, Winter, Silvia Giuliatti, Giusi, Giovanni, da Silva, João Gomes, Zazo, Luis Jorge Gómez, Gomez-Lopez, Juan Manuel, Hernández, Jonay Isai González, Murillo, Kevin Gonzalez, Gorius, Nicolas, Gouel, Pierre-Vincent, Goulty, Duncan, Granata, Valentina, Grenfell, John Lee, Grießbach, Denis, Grolleau, Emmanuel, Grouffal, Salomé, Grziwa, Sascha, Guarcello, Mario Giuseppe, Gueguen, Loïc, Guenther, Eike Wolf, Guilhem, Terrasa, Guillerot, Lucas, Guiot, Pierre, Guterman, Pascal, Gutiérrez, Antonio, Gutiérrez-Canales, Fernando, Hagelberg, Janis, Haldemann, Jonas, Hall, Cassandra, Handberg, Rasmus, Harrison, Ian, Harrison, Diana L., Hasiba, Johann, Haswell, Carole A., Hatalova, Petra, Hatzes, Artie, Haywood, Raphaelle, Hébrard, Guillaume, Heckes, Frank, Heiter, Ulrike, Hekker, Saskia, Heller, René, Helling, Christiane, Helminiak, Krzysztof, Hemsley, Simon, Heng, Kevin, Hermans, Aline, Hermes, JJ, Torres, Nadia Hidalgo, Hinkel, Natalie, Hobbs, David, Hodgkin, Simon, Hofmann, Karl, Hojjatpanah, Saeed, Houdek, Günter, Huber, Daniel, Huesler, Joseph, Hui-Bon-Hoa, Alain, Huygen, Rik, Huynh, Duc-Dat, Iro, Nicolas, Irwin, Jonathan, Irwin, Mike, Izidoro, André, Jacquinod, Sophie, Jannsen, Nicholas Emborg, Janson, Markus, Jeszenszky, Harald, Jiang, Chen, Mancebo, Antonio José Jimenez, Jofre, Paula, Johansen, Anders, Johnston, Cole, Jones, Geraint, Kallinger, Thomas, Kálmán, Szilárd, Kanitz, Thomas, Karjalainen, Marie, Karjalainen, Raine, Karoff, Christoffer, Kawaler, Steven, Kawata, Daisuke, Keereman, Arnoud, Keiderling, David, Kennedy, Tom, Kenworthy, Matthew, Kerschbaum, Franz, Kidger, Mark, Kiefer, Flavien, Kintziger, Christian, Kislyakova, Kristina, Kiss, László, Klagyivik, Peter, Klahr, Hubert, Klevas, Jonas, Kochukhov, Oleg, Köhler, Ulrich, Kolb, Ulrich, Koncz, Alexander, Korth, Judith, Kostogryz, Nadiia, Kovács, Gábor, Kovács, József, Kozhura, Oleg, Krivova, Natalie, Kučinskas, Arunas, Kuhlemann, Ilyas, Kupka, Friedrich, Laauwen, Wouter, Labiano, Alvaro, Lagarde, Nadege, Laget, Philippe, Laky, Gunter, Lam, Kristine Wai Fun, Lambrechts, Michiel, Lammer, Helmut, Lanza, Antonino Francesco, Lanzafame, Alessandro, Martiz, Mariel Lares, Laskar, Jacques, Latter, Henrik, Lavanant, Tony, Lawrenson, Alastair, Lazzoni, Cecilia, Lebre, Agnes, Lebreton, Yveline, Etangs, Alain Lecavelier des, Leinhardt, Zoe, Leleu, Adrien, Lendl, Monika, Leto, Giuseppe, Levillain, Yves, Libert, Anne-Sophie, Lichtenberg, Tim, Ligi, Roxanne, Lignieres, Francois, Lillo-Box, Jorge, Linsky, Jeffrey, Liu, John Scige, Loidolt, Dominik, Longval, Yuying, Lopes, Ilídio, Lorenzani, Andrea, Ludwig, Hans-Guenter, Lund, Mikkel, Lundkvist, Mia Sloth, Luri, Xavier, Maceroni, Carla, Madden, Sean, Madhusudhan, Nikku, Maggio, Antonio, Magliano, Christian, Magrin, Demetrio, Mahy, Laurent, Maibaum, Olaf, Malac-Allain, LeeRoy, Malapert, Jean-Christophe, Malavolta, Luca, Maldonado, Jesus, Mamonova, Elena, Manchon, Louis, Mann, Andrew, Mantovan, Giacomo, Marafatto, Luca, Marconi, Marcella, Mardling, Rosemary, Marigo, Paola, Marinoni, Silvia, Marques, Érico, Marques, Joao Pedro, Marrese, Paola Maria, Marshall, Douglas, Perales, Silvia Martínez, Mary, David, Marzari, Francesco, Masana, Eduard, Mascher, Andrina, Mathis, Stéphane, Mathur, Savita, Figueiredo, Ana Carolina Mattiuci, Maxted, Pierre F. L., Mazeh, Tsevi, Mazevet, Stephane, Mazzei, Francesco, McCormac, James, McMillan, Paul, Menou, Lucas, Merle, Thibault, Meru, Farzana, Mesa, Dino, Messina, Sergio, Mészáros, Szabolcs, Meunier, Nadége, Meunier, Jean-Charles, Micela, Giuseppina, Michaelis, Harald, Michel, Eric, Michielsen, Mathias, Michtchenko, Tatiana, Miglio, Andrea, Miguel, Yamila, Milligan, David, Mirouh, Giovanni, Mitchell, Morgan, Moedas, Nuno, Molendini, Francesca, Molnár, László, Mombarg, Joey, Montalban, Josefina, Montalto, Marco, Monteiro, Mário J. P. F. G., Morales, Juan Carlos, Morales-Calderon, Maria, Morbidelli, Alessandro, Mordasini, Christoph, Moreau, Chrystel, Morel, Thierry, Morello, Guiseppe, Morin, Julien, Mortier, Annelies, Mosser, Benoît, Mourard, Denis, Mousis, Olivier, Moutou, Claire, Mowlavi, Nami, Moya, Andrés, Muehlmann, Prisca, Muirhead, Philip, Munari, Matteo, Musella, Ilaria, Mustill, Alexander James, Nardetto, Nicolas, Nardiello, Domenico, Narita, Norio, Nascimbeni, Valerio, Nash, Anna, Neiner, Coralie, Nelson, Richard P., Nettelmann, Nadine, Nicolini, Gianalfredo, Nielsen, Martin, Niemi, Sami-Matias, Noack, Lena, Noels-Grotsch, Arlette, Noll, Anthony, Norazman, Azib, Norton, Andrew J., Nsamba, Benard, Ofir, Aviv, Ogilvie, Gordon, Olander, Terese, Olivetto, Christian, Olofsson, Göran, Ong, Joel, Ortolani, Sergio, Oshagh, Mahmoudreza, Ottacher, Harald, Ottensamer, Roland, Ouazzani, Rhita-Maria, Paardekooper, Sijme-Jan, Pace, Emanuele, Pajas, Miriam, Palacios, Ana, Palandri, Gaelle, Palle, Enric, Paproth, Carsten, Parro, Vanderlei, Parviainen, Hannu, Granado, Javier Pascual, Passegger, Vera Maria, Pastor-Morales, Carmen, Pätzold, Martin, Pedersen, May Gade, Hidalgo, David Pena, Pepe, Francesco, Pereira, Filipe, Persson, Carina M., Pertenais, Martin, Peter, Gisbert, Petit, Antoine C., Petit, Pascal, Pezzuto, Stefano, Pichierri, Gabriele, Pietrinferni, Adriano, Pinheiro, Fernando, Pinsonneault, Marc, Plachy, Emese, Plasson, Philippe, Plez, Bertrand, Poppenhaeger, Katja, Poretti, Ennio, Portaluri, Elisa, Portell, Jordi, de Mello, Gustavo Frederico Porto, Poyatos, Julien, Pozuelos, Francisco J., Moroni, Pier Giorgio Prada, Pricopi, Dumitru, Prisinzano, Loredana, Quade, Matthias, Quirrenbach160, ndreas, Reina6, Julio Arturo Rabanal, Soares, Maria Cristina Rabello, Raimondo, Gabriella, Rainer, Monica, Rodón, Jose Ramón, Ramón-Ballesta, Alejandro, Zapata, Gonzalo Ramos, Rätz, Stefanie, Rauterberg, Christoph, Redman, Bob, Redmer, Ronald, Reese, Daniel, Regibo, Sara, Reiners, Ansgar, Reinhold, Timo, Renie, Christian, Ribas, Ignasi, Ribeiro, Sergio, Ricciardi, Thiago Pereira, Rice, Ken, Richard, Olivier, Riello, Marco, Rieutord, Michel, Ripepi, Vincenzo, Rixon, Guy, Rockstein, Steve, Rodríguez, María Teresa Rodrigo, Díaz, Luisa Fernanda Rodríguez, Garcia, Juan Pablo Rodriguez, Rodriguez-Gomez, Julio, Roehlly, Yannick, Roig, Fernando, Rojas-Ayala, Bárbara, Rolf, Tobias, Rørsted, Jakob Lysgaard, Rosado, Hugo, Rosotti, Giovanni, Roth, Olivier, Roth, Markus, Rousseau, Alex, Roxburgh, Ian, Roy, Fabrice, Royer, Pierre, Ruane, Kirk, Mastropasqua, Sergio Rufini, de Galarreta, Claudia Ruiz, Russi, Andrea, Saar, Steven, Saillenfest, Melaine, Salaris, Maurizio, Salmon, Sebastien, Saltas, Ippocratis, Samadi, Réza, Samadi, Aunia, Samra, Dominic, da Silva, Tiago Sanches, Carrasco, Miguel Andrés Sánchez, Santerne, Alexandre, Santoli, Francesco, Santos, Ângela R. G., Mesa, Rosario Sanz, Sarro, Luis Manuel, Scandariato, Gaetano, Schäfer, Martin, Schlafly, Edward, Schmider, François-Xavier, Schneider, Jean, Schou, Jesper, Schunker, Hannah, Schwarzkopf, Gabriel Jörg, Serenelli, Aldo, Seynaeve, Dries, Shan, Yutong, Shapiro, Alexander, Shipman, Russel, Sicilia, Daniela, Sanmartin, Maria Angeles Sierra, Sigot, Axelle, Silliman, Kyle, Silvotti, Roberto, Simon, Attila E., Napoli, Ricardo Simoyama, Skarka, Marek, Smalley, Barry, Smiljanic, Rodolfo, Smit, Samuel, Smith, Alexis, Smith, Leigh, Snellen, Ignas, Sódor, Ádám, Sohl, Frank, Solanki, Sami K., Sortino, Francesca, Sousa, Sérgio, Southworth, John, Souto, Diogo, Sozzetti, Alessandro, Stamatellos, Dimitris, Stassun, Keivan, Steller, Manfred, Stello, Dennis, Stelzer, Beate, Stiebeler, Ulrike, Stokholm, Amalie, Storelvmo, Trude, Strassmeier, Klaus, Strøm, Paul Anthony, Strugarek, Antoine, Sulis, Sophia, Švanda, Michal, Szabados, László, Szabó, Róbert, Szabó, Gyula M., Szuszkiewicz, Ewa, Talens, Geert Jan, Teti, Daniele, Theisen, Tom, Thévenin, Frédéric, Thoul, Anne, Tiphene, Didier, Titz-Weider, Ruth, Tkachenko, Andrew, Tomecki, Daniel, Tonfat, Jorge, Tosi, Nicola, Trampedach, Regner, Traven, Gregor, Triaud, Amaury, Trønnes, Reidar, Tsantaki, Maria, Tschentscher, Matthias, Turin, Arnaud, Tvaruzka, Adam, Ulmer, Bernd, Ulmer-Moll, Solène, Ulusoy, Ceren, Umbriaco, Gabriele, Valencia, Diana, Valentini, Marica, Valio, Adriana, Guijarro, Ángel Luis Valverde, Van Eylen, Vincent, Van Grootel, Valerie, van Kempen, Tim A., Van Reeth, Timothy, Van Zelst, Iris, Vandenbussche, Bart, Vasiliou, Konstantinos, Vasilyev, Valeriy, de Mascarenhas, David Vaz, Vazan, Allona, Nunez, Marina Vela, Velloso, Eduardo Nunes, Ventura, Rita, Ventura, Paolo, Venturini, Julia, Trallero, Isabel Vera, Veras, Dimitri, Verdugo, Eva, Verma, Kuldeep, Vibert, Didier, Martinez, Tobias Vicanek, Vida, Krisztián, Vigan, Arthur, Villacorta, Antonio, Villaver, Eva, Aparicio, Marcos Villaverde, Viotto, Valentina, Vorobyov, Eduard, Vorontsov, Sergey, Wagner, Frank W., Walloschek, Thomas, Walton, Nicholas, Walton, Dave, Wang, Haiyang, Waters, Rens, Watson, Christopher, Wedemeyer, Sven, Weeks, Angharad, Weingril, Jörg, Weiss, Annita, Wendler, Belinda, West, Richard, Westerdorff, Karsten, Westphal, Pierre-Amaury, Wheatley, Peter, White, Tim, Whittaker, Amadou, Wickhusen, Kai, Wilson, Thomas, Windsor, James, Winter, Othon, Winther, Mark Lykke, Winton, Alistair, Witteck, Ulrike, Witzke, Veronika, Woitke, Peter, Wolter, David, Wuchterl, Günther, Wyatt, Mark, Yang, Dan, Yu, Jie, Sanchez, Ricardo Zanmar, Osorio, María Rosa Zapatero, Zechmeister, Mathias, Zhou, Yixiao, Ziemke, Claas, and Zwintz, Konstanze
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
PLATO (PLAnetary Transits and Oscillations of stars) is ESA's M3 mission designed to detect and characterise extrasolar planets and perform asteroseismic monitoring of a large number of stars. PLATO will detect small planets (down to <2 R_(Earth)) around bright stars (<11 mag), including terrestrial planets in the habitable zone of solar-like stars. With the complement of radial velocity observations from the ground, planets will be characterised for their radius, mass, and age with high accuracy (5 %, 10 %, 10 % for an Earth-Sun combination respectively). PLATO will provide us with a large-scale catalogue of well-characterised small planets up to intermediate orbital periods, relevant for a meaningful comparison to planet formation theories and to better understand planet evolution. It will make possible comparative exoplanetology to place our Solar System planets in a broader context. In parallel, PLATO will study (host) stars using asteroseismology, allowing us to determine the stellar properties with high accuracy, substantially enhancing our knowledge of stellar structure and evolution. The payload instrument consists of 26 cameras with 12cm aperture each. For at least four years, the mission will perform high-precision photometric measurements. Here we review the science objectives, present PLATO's target samples and fields, provide an overview of expected core science performance as well as a description of the instrument and the mission profile at the beginning of the serial production of the flight cameras. PLATO is scheduled for a launch date end 2026. This overview therefore provides a summary of the mission to the community in preparation of the upcoming operational phases.
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- 2024
35. Estimate for the neutrino magnetic moment from pulsar kick velocities induced at the birth of strange quark matter neutron stars
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Ayala, Alejandro, Bernal-Langarica, Santiago, and Manreza-Paret, Daryel
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High Energy Physics - Phenomenology ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
We estimate the magnetic moment of electron neutrinos by computing the neutrino chirality flip rate that can occur in the core of a strange quark matter neutron star at birth. We show that this process allows neutrinos to anisotropically escape, thus inducing the star kick velocity. Although the flip from left- to right-handed neutrinos is assumed to happen in equilibrium, the no-go theorem does not apply because right-handed neutrinos do not interact with matter and the reverse process does not happen, producing the loss of detailed balance. For simplicity, we model the star core as consisting of strange quark matter. We find that even when the energy released in right-handed neutrinos is a small fraction of the total energy released in left-handed neutrinos, the process describes kick velocities for natal conditions, which are consistent with the observed ones and span the correct range of radii, temperatures and chemical potentials for typical magnetic field intensities. The neutrino magnetic moment is estimated to be $\mu_\nu \sim 3.6 \times 10^{-18}\mu_B$, where $\mu_B$ is the Bohr magneton. This value is more stringent than the bound found for massive neutrinos in a minimal extension of the \mbox{standard model.}, Comment: 7 pages, no figures. Version accepted for publication in Universe
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- 2024
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36. 50 GeV $\pi^-$ in, nothing out: a sensitive probe of invisible $\eta$ and $\eta'$ decays with NA64h
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Andreev, Yu. M., Antonov, A., Torres, M. A. Ayala, Banerjee, D., Oberhauser, B. Banto, Bernhard, J., Bisio, P., Celentano, A., Charitonidis, N., Cooke, D., Crivelli, P., Depero, E., Dermenev, A. V., Donskov, S. V., Dusaev, R. R., Enik, T., Frolov, V. N., Gertsenberger, S. V., Girod, S., Gninenko, S. N., Hosgen, M., Kachanov, V. A., Kambar, Y., Karneyeu, A. E., Kekelidze, G. D., Ketzer, B., Kirpichnikov, D. V., Kolosov, V. N., Kramarenko, V. A., Kravchuk, L. V., Krasnikov, N. V., Kuleshov, S. V., Lyubovitskij, V. E., Marini, A., Marsicano, L., Matveev, V. A., Fredes, R. Mena, Yanssen, R. G. Mena, Bueno, L. Molina, Mongillo, M., Peshekhonov, D. V., Polyakov, V. A., Radics, B., Salamatin, K. M., Samoylenko, V. D., Sieber, H., Shchukin, D. A., Soto, O., Tikhomirov, V. O., Tlisova, I. V., Toropin, A. N., Tuzi, M., Volkov, P. V., Volkov, V. Yu., Voronchikhin, I. V., Zamora-Saa, J., and Zhevlakov, A. S.
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High Energy Physics - Experiment ,High Energy Physics - Phenomenology - Abstract
We present the first results from a proof-of-concept search for dark sectors via invisible decays of pseudoscalar $\eta$ and $\eta'$ mesons in the NA64h experiment at the CERN SPS. Our novel technique uses the charge-exchange reaction of 50 GeV $\pi^-$ on nuclei of an active target as the source of neutral mesons. The $\eta, \eta' \to invisible$ events would exhibit themselves via a striking signature - the complete disappearance of the incoming beam energy in the detector. No evidence for such events has been found with $2.9\times10^{9}$ pions on target accumulated during one day of data taking. This allows us to set a stringent limit on the branching ratio ${\rm Br}(\eta' \to invisible) < 2.1 \times 10^{-4}$ improving the current bound by a factor of $\simeq3$. We also set a limit on ${\rm Br}(\eta \to invisible) < 1.1 \times 10^{-4}$ comparable with the existing one. These results demonstrate the great potential of our approach and provide clear guidance on how to enhance and extend the sensitivity for dark sector physics from future searches for invisible neutral meson decays., Comment: 5 pages, 3 figures
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- 2024
37. Socioeconomic Gaps in Specific Mathematical Skills at Different Ages in Primary School
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M. Constanza Ayala, Katherine Strasser, María Inés Susperreguy, and Karla Castillo
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Mathematical skills significantly predict students' educational paths. Mathematical achievement varies depending on the student's socioeconomic status (SES). However, the extent of the SES gap for specific mathematical skills remains unclear. In this cross-sectional study, we examined age variations by SES in three mathematical skills, applied problem-solving, arithmetic fluency, and written calculations, among students aged 7-12 in a socioeconomically segregated educational context. The contributions of the home environment and schools on SES gaps were also explored. The analytical sample comprised 10,665 students (49.2% girls, M[subscript age] = 10.1, SD = 1.3 years, 13.4% from Indigenous ethnic groups) from the Chilean Early Childhood Longitudinal Survey (Encuesta Longitudinal de Primera Infancia). Linear models revealed SES gaps across the three mathematical tasks at the beginning of primary education. The widest gap was observed in written calculations, which was moderated by the home environment. The findings also showed an exponential increase with age in the SES gap for written calculations and arithmetic fluency. However, for applied problem-solving, the initial gap increased and remained constant. Furthermore, schools accounted for 19%-21% of the variance related to the change of the SES gap in all three mathematical skills. The findings shed some light on the role of the home environment and the schools in maintaining, increasing, or decreasing socioeconomic gaps in specific mathematical skills at different ages.
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- 2024
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38. A Systematic Review of Recruiting and Retaining Sociodemographically Diverse Families in Neurodevelopmental Research Studies
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Sarah S. Mire, Dieu M. Truong, Georgina J. Sakyi, Mycah L. Ayala-Brittain, Jelisa D. Boykin, Christian M. Stewart, Fre'Dasia Daniels, Brenda Duran, Scarlett Gardner, Alexandra M. Barth, Georgette Richardson, and Shannon L. McKee
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Underrepresentation of socioeconomically, culturally, and/or linguistically diverse (SCLD) children with neurodevelopmental disorders (NDD) and their families has become a focal point for researchers. This systematic review aimed to identify researchers' strategies for recruiting and retaining SCLD families of children with NDD, published between 1993 and 2018. One hundred twenty-six articles were included, and study samples were categorized as "High SCLD" and "Low SCLD". Chi-square tests of independence were used to determine associations between sample composition (i.e., High/Low SCLD sample) and study characteristics reported. Significant associations were found between sample composition and studies that explicitly stated intention to recruit SCLD families, X[superscript 2](1) = 12.70, p < 0.001, Phi = 0.38 (moderate); and for studies that reported the following participant characteristics: language, X[superscript 2](1) = 29.58, p < 0.001, Phi = 0.48 (moderate-to-large); and race/ethnicity + SES + language, X[superscript 2](1) = 19.26, p < 0.001, Phi = 0.39 (moderate). However, associations were not found between recruitment and retention approaches and whether studies included High SCLD or Low SCLD samples. Further study of NDD researchers' recruitment and retention approaches that successfully include SCLD families is needed.
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- 2024
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39. Factors Associated with Proportionality of Representation of Children of Color in Early Childhood Special Education in Illinois
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Kaitlyn Ayala
- Abstract
Globally, early childhood education is seen as a right for children and yet, while several nations have instituted universal early childhood education policies to ensure that all children have access to it, the United States faces several challenges. In addition to lacking a universal federal mandate for early childhood education, the United States' implementation of its current educational policy surrounding early childhood (IDEA) may be inappropriate. Research indicates that children of color are often over-represented or under-represented in special education, including in early childhood settings. Research has yet to focus more specifically on exploring how far removed children of color are from proportionate representation in special education in their schools and which factors are associated with more proportionate representation of children of color in special education. The current study investigated early childhood centers in Illinois and found that the diversity of a school's student body, the diversity of the district's teaching staff, the educational attainment of the district's teaching staff, and the geographical location are all associated with the proportionality of representation of children of color in special education in early childhood. Implications for administrators and future research directions are discussed.
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- 2024
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40. The mouse metabolic phenotyping center (MMPC) live consortium: an NIH resource for in vivo characterization of mouse models of diabetes and obesity
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Laughlin, Maren, McIndoe, Richard, Adams, Sean H, Araiza, Renee, Ayala, Julio E, Kennedy, Lucy, Lanoue, Louise, Lantier, Louise, Macy, James, Malabanan, Eann, McGuinness, Owen P, Perry, Rachel, Port, Daniel, Qi, Nathan, Elias, Carol F, Shulman, Gerald I, Wasserman, David H, and Lloyd, KC Kent
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Biological Sciences ,Genetics ,Obesity ,Nutrition ,Behavioral and Social Science ,Diabetes ,Metabolic and endocrine ,Good Health and Well Being ,Metabolism ,Mouse ,Phenotyping ,In vivo ,Resource ,Service ,Tests ,Animals ,Mice ,Diabetes Mellitus ,Disease Models ,Animal ,Phenotype ,National Institutes of Health (U.S.) ,United States ,National Institute of Diabetes and Digestive and Kidney Diseases (U.S.) ,Genetics & Heredity - Abstract
The Mouse Metabolic Phenotyping Center (MMPC)Live Program was established in 2023 by the National Institute for Diabetes, Digestive and Kidney Diseases (NIDDK) at the National Institutes of Health (NIH) to advance biomedical research by providing the scientific community with standardized, high quality phenotyping services for mouse models of diabetes and obesity. Emerging as the next iteration of the MMPC Program which served the biomedical research community for 20 years (2001-2021), MMPCLive is designed as an outwardly-facing consortium of service cores that collaborate to provide reduced-cost consultation and metabolic, physiologic, and behavioral phenotyping tests on live mice for U.S. biomedical researchers. Four MMPCLive Centers located at universities around the country perform complex and often unique procedures in vivo on a fee for service basis, typically on mice shipped from the client or directly from a repository or vendor. Current areas of expertise include energy balance and body composition, insulin action and secretion, whole body carbohydrate and lipid metabolism, cardiovascular and renal function, food intake and behavior, microbiome and xenometabolism, and metabolic pathway kinetics. Additionally, an opportunity arose to reduce barriers to access and expand the diversity of the biomedical research workforce by establishing the VIBRANT Program. Directed at researchers historically underrepresented in the biomedical sciences, VIBRANT-eligible investigators have access to testing services, travel and career development awards, expert advice and experimental design consultation, and short internships to learn test technologies. Data derived from experiments run by the Centers belongs to the researchers submitting mice for testing which can be made publicly available and accessible from the MMPCLive database following publication. In addition to services, MMPCLive staff provide expertise and advice to researchers, develop and refine test protocols, engage in outreach activities, publish scientific and technical papers, and conduct educational workshops and training sessions to aid researchers in unraveling the heterogeneity of diabetes and obesity.
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- 2024
41. Self-regulating CAR-T cells modulate cytokine release syndrome in adoptive T-cell therapy.
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Lin, Meng-Yin, Nam, Eunwoo, Shih, Ryan, Shafer, Amanda, Bouren, Amber, Ayala Ceja, Melanie, Harris, Caitlin, Khericha, Mobina, Vo, Kenny, Kim, Minsoo, Tseng, Chi-Hong, and Chen, Yvonne
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Animals ,Mice ,Cytokine Release Syndrome ,Cytokines ,Adaptor Proteins ,Signal Transducing ,Antigens ,CD19 ,Cell- and Tissue-Based Therapy - Abstract
Cytokine release syndrome (CRS) is a frequently observed side effect of chimeric antigen receptor (CAR)-T cell therapy. Here, we report self-regulating T cells that reduce CRS severity by secreting inhibitors of cytokines associated with CRS. With a humanized NSG-SGM3 mouse model, we show reduced CRS-related toxicity in mice treated with CAR-T cells secreting tocilizumab-derived single-chain variable fragment (Toci), yielding a safety profile superior to that of single-dose systemic tocilizumab administration. Unexpectedly, Toci-secreting CD19 CAR-T cells exhibit superior in vivo antitumor efficacy compared with conventional CD19 CAR-T cells. scRNA-seq analysis of immune cells recovered from tumor-bearing humanized mice revealed treatment with Toci-secreting CD19 CAR-T cells enriches for cytotoxic T cells while retaining memory T-cell phenotype, suggesting Toci secretion not only reduces toxicity but also significantly alters the overall T-cell composition. This approach of engineering T cells to self-regulate inflammatory cytokine production is a clinically compatible strategy with the potential to simultaneously enhance safety and efficacy of CAR-T cell therapy for cancer.
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- 2024
42. Addressing the unmet needs of women with breast cancer in Mexico: a non-randomised pilot study of the digital ePRO intervention
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Sánchez, Saúl Eduardo Contreras, Doubova, Svetlana V, Vega, Ingrid Patricia Martinez, Álvarez, Rocío Grajales, Valencia, Ricardo Villalobos, Borunda, Abdel Karim Dip, Mondragón, Lorena Lio, Pineda, Wendy Jazmín Martínez, Cerrillo, Jose Gustavo Nuñez, López, Alma Diana Huerta, Velázquez, Rita Zalapa, Ortiz, Valeria Mendoza, Zamora, Víctor Javier Vázquez, Jarquín, Álvaro José Montiel, Galicia, Arturo García, Gómez, Enrique Isay Talamantes, Reyes, Roberto Sánchez, Gómez, Jaqueline Aguirre, Anzures, María Eugenia Ayala, Tarrés, Marta Zapata, Monroy, Adriana, and Leslie, Hannah H
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Health Services and Systems ,Nursing ,Health Sciences ,Behavioral and Social Science ,Breast Cancer ,Clinical Research ,Women's Health ,Cancer ,Clinical Trials and Supportive Activities ,Health Services ,7.1 Individual care needs ,Management of diseases and conditions ,Good Health and Well Being ,Humans ,Female ,Breast Neoplasms ,Pilot Projects ,Middle Aged ,Mexico ,Adult ,Aged ,Quality of Life ,Patient Reported Outcome Measures ,Young Adult ,Internet-Based Intervention ,Feasibility Studies ,breast tumours ,ehealth ,nurses ,Clinical Sciences ,Public Health and Health Services ,Other Medical and Health Sciences ,Biomedical and clinical sciences ,Health sciences ,Psychology - Abstract
ObjectivesThis study aimed to explore the acceptability, feasibility, usability, and preliminary effect of an electronic patient-reported outcome (ePRO) intervention for patients with breast cancer in Mexico.DesignWe conducted a multimethod non-randomised pilot study. We used a pre-test/post-test design for quantitative assessment of the intervention's effect on patients' supportive care needs and quality of life. We conducted in-depth interviews (IDIs) with participants and healthcare workers to explore the intervention's benefits and barriers and understand its feasibility.Participants50 women aged 20-75 diagnosed with stage I-III breast cancer were enrolled within 2 weeks of starting neoadjuvant or adjuvant treatment with chemotherapy or radiotherapy. We excluded illiterate women and those with visual impairment, cognitive disability or severe depression. IDIs were conducted with 18 participants and 10 healthcare providers.SettingOncology services in three public hospitals of the Mexican Social Security Institute.InterventionThe ePRO intervention consisted of a responsive web application for weekly symptom reporting combined with proactive follow-up by nurses guided by predefined clinical algorithms for 6 weeks.Results50 women were enrolled out of 66 eligible patients approached (75.8%). All 50 completed the 4-week follow-up assessment (100% retention). Completion of the symptom registry declined from 100% in week 1 to 66% in week 6. Participants experienced decreases in supportive care needs and increased quality of life. The ePRO application was rated highly usable. Participants and health professionals both perceived intervention benefits. Drawbacks included poor fit for women receiving radiotherapy and challenges using the application for women with low digital literacy or experiencing severe symptoms.ConclusionsThis pilot study provided evidence of the high usability and potential efficacy of a web-based ePRO intervention. We revised recruitment during the pilot to include multiple facilities, and we will further revise for the randomised trial to address barriers to successful ePRO implementation.Trial registration numberClinicalTrials.gov ID: NCT05925257.
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- 2024
43. Group Dispersal Modelling Revisited
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Ayala, Mario, Coville, Jérôme, and Soubeyrand, Samuel
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Mathematics - Analysis of PDEs ,Mathematics - Probability ,Quantitative Biology - Quantitative Methods - Abstract
In this paper we revisit the notion of grouped dispersal that have been introduced by Soubeyrand and co-authors \cite{soubeyrand2011patchy} to model the simultaneous (and hence dependent) dispersal of several propagules from a single source in a homogeneous environment. We built a time continuous measure valued process that takes into account the main feature of a grouped dispersal and derive its infinitesimal generator. To cope with the mutligeneration aspect associated to the demography we introduce two types of propagules in the description of the population which is one of the main innovations here. We also provide a rigorous description of the process and its generator. We derive as well, some large population asymptotics of the process unveilling the degenerate ultra parabolic system of PDE satisfied by the density of population. Finally, we also show that such a PDE system has a non-trivial solution which is unique in a certain functional space.
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- 2024
44. Performance of the HAWC Observatory and TeV Gamma-Ray Measurements of the Crab Nebula with Improved Extensive Air Shower Reconstruction Algorithms
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Albert, A ., Alfaro, R., Alvarez, C., Andrés, A ., Arteaga-Velázquez, J. C., Rojas, D. Avila, Solares, H. A. Ayala, Babu, R., Belmont-Moreno, E., Caballero-Mora, K. S., Capistrán, T., Carramiñana, A., Casanova, S., Cotti, U., Cotzomi, J., de León, S. Coutiño, De la Fuente, E., de León, C., Depaoli, D., Di Lalla, N., Hernandez, R. Diaz, Dingus, B. L ., DuVernois, M. A., Engel, K., Ergin, T., Espinoza, C ., Fan, K. L., Fang, K., Fraija, N., Fraija, S., García-González, J. A., Garfias, F., Goksu, H ., González, M. M., Goodman, J. A., Groetsch, S., Harding, J. P., Hernández-Cadena, S., Herzog, I., Hinton, J ., Huang, D., Hueyotl-Zahuantitla, F., Hüntemeyer, P., Iriarte, A., Kaufmann, S., Lara, A ., Lee, J., Vargas, H. León, Linnemann, J. T ., Longinotti, A. L., Luis-Raya, G., Malone, K., Martínez-Castro, J., Matthews, J. A., Miranda-Romagnoli, P., Montes, J. A., Moreno, E., Mostafá, M., Nellen, L., Nisa, M. U ., Noriega-Papaqui, R ., Olivera-Nieto, L ., Omodei, N., Osorio, M., Araujo, Y. Pérez, Pérez-Pérez, E. G., Rho, C. D., Rosa-González, D., Ruiz-Velasco, E ., Salazar, H., Salazar-Gallegos, D., Sandoval, A., Schneider, M., Schwefer, G ., Serna-Franco, J., Smith, A. J., Son, Y., Springer, R. W ., Tibolla, O., Tollefson, K., Torres, I., Torres-Escobedo, R., Turner, R., Ureña-Mena, F., Varela, E ., Wang, X., Watson, I. J., Whitaker, K., Willox, E., Wu, H., Yu, S ., Yun-Cárcamo, S., and Zhou, H.
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The High-Altitude Water Cherenkov (HAWC) Gamma-Ray Observatory located on the side of the Sierra Negra volcano in Mexico, has been fully operational since 2015. The HAWC collaboration has recently significantly improved their extensive-air-shower reconstruction algorithms, which has notably advanced the observatory performance. The energy resolution for primary gamma rays with energies below 1~TeV was improved by including a noise-suppression algorithm. Corrections have also been made to systematic errors in direction fitting related to the detector and shower plane inclinations, $\mathcal{O}(0.1^{\circ})$ biases in highly inclined showers, as well as enhancements to the core reconstruction. The angular resolution for gamma rays approaching the HAWC array from large zenith angles ($> 37^{\circ}$) has improved by a factor of four at the highest energies ($> 70$~TeV) as compared to previous reconstructions. The inclusion of a lateral distribution function fit to the extensive air shower footprint on the array to separate gamma-ray primaries from cosmic-ray ones, based on the resulting $\chi^{2}$ values, improved the background rejection performance at all inclinations. At large zenith angles, the improvement in significance is a factor of four compared to previous HAWC publications. These enhancements have been verified by observing the Crab Nebula, which is an overhead source for the HAWC Observatory. We show that the sensitivity to Crab-like point sources ($E^{-2.63}$) with locations overhead to 30$^{\circ}$ zenith is comparable or less than 10\% of the Crab Nebula's flux between 2 and 50~TeV. Thanks to these improvements, HAWC can now detect more sources, including the Galactic Center.
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- 2024
45. Search for joint multimessenger signals from potential Galactic PeVatrons with HAWC and IceCube
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Alfaro, R., Alvarez, C., Arteaga-Velázquez, J. C., Rojas, D. Avila, Solares, H. A. Ayala, Babu, R., Belmont-Moreno, E., Caballero-Mora, K. S., Capistrán, T., Carramiñana, A., Casanova, S., Cotti, U., Cotzomi, J., de León, S. Coutiño, De la Fuente, E., Depaoli, D., Di Lalla, N., Hernandez, R. Diaz, Díaz-Vélez, J. C., Engel, K., Ergin, T., Fan, K. L., Fang, K., Fraija, N., Fraija, S., García-González, J. A., Garfias, F., González, M. M., Goodman, J. A., Groetsch, S., Harding, J. P., Hernández-Cadena, S., Herzog, I., Huang, D., Hueyotl-Zahuantitla, F., Hüntemeyer, P., Iriarte, A., Kaufmann, S., Lee, J., Vargas, H. León, Longinotti, A. L., Luis-Raya, G., Malone, K., Martínez-Castro, J., Matthews, J. A., Miranda-Romagnoli, P., Montes, J. A., Moreno, E., Mostafá, M., Nellen, L., Omodei, N., Osorio, M., Araujo, Y. Pérez, Pérez-Pérez, E. G., Rho, C. D., Rosa-González, D., Salazar, H., Salazar-Gallegos, D., Sandoval, A., Schneider, M., Serna-Franco, J., Smith, A. J., Son, Y., Tibolla, O., Tollefson, K., Torres, I., Torres-Escobedo, R., Turner, R., Ureña-Mena, F., Wang, X., Watson, I. J., Whitaker, K., Willox, E., Wu, H., Yun-Cárcamo, S., Zhou, H., de León, C., Abbasi, R., Ackermann, M., Adams, J., Agarwalla, S. K., Aguilar, J. A., Ahlers, M., Alameddine, J. M., Amin, N. M., Andeen, K., Argüelles, C., Ashida, Y., Athanasiadou, S., Ausborm, L., Axani, S. N., Bai, X., V., A. Balagopal, Baricevic, M., Barwick, S. W., Bash, S., Basu, V., Bay, R., Beatty, J. J., Tjus, J. Becker, Beise, J., Bellenghi, C., Benning, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Blaufuss, E., Bloom, L., Blot, S., Bontempo, F., Motzkin, J. Y. Book, Meneguolo, C. Boscolo, Böser, S., Botner, O., Böttcher, J., Braun, J., Brinson, B., Brostean-Kaiser, J., Brusa, L., Burley, R. T., Butterfield, D., Campana, M. A., Caracas, I., Carloni, K., Carpio, J., Chattopadhyay, S., Chau, N., Chen, Z., Chirkin, D., Choi, S., Clark, B. A., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Corley, R., Correa, P., Cowen, D. F., Dave, P., De Clercq, C., DeLaunay, J. J., Delgado, D., Deng, S., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., DeYoung, T., Diaz, A., Dierichs, P., Dittmer, M., Domi, A., Draper, L., Dujmovic, H., Dutta, K., DuVernois, M. A., Ehrhardt, T., Eidenschink, L., Eimer, A., Eller, P., Ellinger, E., Mentawi, S. El, Elsässer, D., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Farrag, K., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Fukami, S., Fürst, P., Gallagher, J., Ganster, E., Garcia, A., Garcia, M., Garg, G., Genton, E., Gerhardt, L., Ghadimi, A., Girard-Carillo, C., Glaser, C., Glüsenkamp, T., Gonzalez, J. G., Goswami, S., Granados, A., Grant, D., Gray, S. J., Gries, O., Griffin, S., Griswold, S., Groth, K. M., Günther, C., Gutjahr, P., Ha, C., Haack, C., Hallgren, A., Halve, L., Halzen, F., Hamdaoui, H., Minh, M. Ha, Handt, M., Hanson, K., Hardin, J., Harnisch, A. A., Hatch, P., Haungs, A., Häußler, J., Helbing, K., Hellrung, J., Hermannsgabner, J., Heuermann, L., Heyer, N., Hickford, S., Hidvegi, A., Hill, C., Hill, G. C., Hoffman, K. D., Hori, S., Hoshina, K., Hostert, M., Hou, W., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., Ishihara, A., Iwakiri, W., Jacquart, M., Janik, O., Jansson, M., Japaridze, G. S., Jeong, M., Jin, M., Jones, B. J. P., Kamp, N., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katil, A., Katz, U., Kauer, M., Kelley, J. L., Khanal, M., Zathul, A. Khatee, Kheirandish, A., Kiryluk, J., Klein, S. R., Kochocki, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Krishnamoorthi, J., Kruiswijk, K., Krupczak, E., Kumar, A., Kun, E., Kurahashi, N., Lad, N., Gualda, C. Lagunas, Lamoureux, M., Larson, M. J., Latseva, S., Lauber, F., Lazar, J. P., Lee, J. W., DeHolton, K. Leonard, Leszczyńska, A., Liao, J., Lincetto, M., Liu, Y. T., Liubarska, M., Lohfink, E., Love, C., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Luszczak, W., Lyu, Y., Madsen, J., Magnus, E., Mahn, K. B. M., Makino, Y., Manao, E., Mancina, S., Sainte, W. Marie, Mariş, I. C., Marka, S., Marka, Z., Marsee, M., Martinez-Soler, I., Maruyama, R., Mayhew, F., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Merckx, Y., Merten, L., Micallef, J., Mitchell, J., Montaruli, T., Moore, R. W., Morii, Y., Morse, R., Moulai, M., Mukherjee, T., Naab, R., Nagai, R., Nakos, M., Naumann, U., Necker, J., Negi, A., Neste, L., Neumann, M., Niederhausen, H., Noda, K., Noell, A., Novikov, A., Pollmann, A. Obertacke, O'Dell, V., Oeyen, B., Olivas, A., Orsoe, R., Osborn, J., O'Sullivan, E., Pandya, H., Park, N., Parker, G. K., Paudel, E. N., Paul, L., Heros, C. Pérez de los, Pernice, T., Peterson, J., Philippen, S., Pizzuto, A., Plum, M., Pontén, A., Popovych, Y., Rodriguez, M. Prado, Pries, B., Procter-Murphy, R., Przybylski, G. T., Raab, C., Rack-Helleis, J., Ravn, M., Rawlins, K., Rechav, Z., Rehman, A., Reichherzer, P., Resconi, E., Reusch, S., Rhode, W., Riedel, B., Rifaie, A., Roberts, E. J., Robertson, S., Rodan, S., Roellinghoff, G., Rongen, M., Rosted, A., Rott, C., Ruhe, T., Ruohan, L., Ryckbosch, D., Safa, I., Saffer, J., Sampathkumar, P., Sandrock, A., Santander, M., Sarkar, S., Savelberg, J., Savina, P., Schaile, P., Schaufel, M., Schieler, H., Schindler, S., Schlüter, B., Schlüter, F., Schmeisser, N., Schmidt, T., Schneider, J., Schröder, F. G., Schumacher, L., Sclafani, S., Seckel, D., Seikh, M., Seo, M., Seunarine, S., Myhr, P. Sevle, Shah, R., Shefali, S., Shimizu, N., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Søgaard, A., Soldin, D., Soldin, P., Sommani, G., Spannfellner, C., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Terliuk, A., Thiesmeyer, M., Thompson, W. G., Thwaites, J., Tilav, S., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Turcotte, R., Twagirayezu, J. P., Elorrieta, M. A. Unland, Upadhyay, A. K., Upshaw, K., Vaidyanathan, A., Valtonen-Mattila, N., Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., van Santen, J., Vara, J., Veitch-Michaelis, J., Venugopal, M., Vereecken, M., Verpoest, S., Veske, D., Vijai, A., Walck, C., Wang, A., Weaver, C., Weigel, P., Weindl, A., Weldert, J., Wen, A. Y., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Williams, D. R., Witthaus, L., Wolf, A., Wolf, M., Wrede, G., Xu, X. W., Yanez, J. P., Yildizci, E., Yoshida, S., Young, R., Yu, S., Yuan, T., Zhang, Z., Zhelnin, P., Zilberman, P., and Zimmerman, M.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Galactic PeVatrons are sources that can accelerate cosmic rays to PeV energies. The high-energy cosmic rays are expected to interact with the surrounding ambient material or radiation, resulting in the production of gamma rays and neutrinos. To optimize for the detection of such associated production of gamma rays and neutrinos for a given source morphology and spectrum, a multi-messenger analysis that combines gamma rays and neutrinos is required. In this study, we use the Multi-Mission Maximum Likelihood framework (3ML) with IceCube Maximum Likelihood Analysis software (i3mla) and HAWC Accelerated Likelihood (HAL) to search for a correlation between 22 known gamma-ray sources from the third HAWC gamma-ray catalog and 14 years of IceCube track-like data. No significant neutrino emission from the direction of the HAWC sources was found. We report the best-fit gamma-ray model and 90% CL neutrino flux limit from the 22 sources. From the neutrino flux limit, we conclude that the gamma-ray emission from five of the sources can not be produced purely from hadronic interactions. We report the limit for the fraction of gamma rays produced by hadronic interactions for these five sources.
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- 2024
46. Symmetries of the cyclic nerve
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Ayala, David, Mazel-Gee, Aaron, and Rozenblyum, Nick
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Mathematics - Algebraic Topology ,Mathematics - Category Theory ,Mathematics - K-Theory and Homology - Abstract
We undertake a systematic study of the Hochschild homology, i.e. (the geometric realization of) the cyclic nerve, of $(\infty,1)$-categories (and more generally of category-objects in an $\infty$-category), as a version of factorization homology. In order to do this, we codify $(\infty,1)$-categories in terms of quiver representations in them. By examining a universal instance of such Hochschild homology, we explicitly identify its natural symmetries, and construct a non-stable version of the cyclotomic trace map. Along the way we give a unified account of the cyclic, paracyclic, and epicyclic categories. We also prove that this gives a combinatorial description of the $n=1$ case of factorization homology as presented in [AFR18], which parametrizes $(\infty,1)$-categories by solidly 1-framed stratified spaces.
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- 2024
47. MemorAI: Energy-Efficient Last-Level Cache Memory Optimization for Virtualized RANs
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Hidalgo, Ethan Sanchez, Lozano, J. Xavier Salvat, Ayala-Romero, Jose A., Garcia-Saavedra, Andres, Li, Xi, and Costa-Perez, Xavier
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Computer Science - Networking and Internet Architecture - Abstract
The virtualization of Radio Access Networks (vRAN) is well on its way to become a reality, driven by its advantages such as flexibility and cost-effectiveness. However, virtualization comes at a high price - virtual Base Stations (vBSs) sharing the same computing platform incur a significant computing overhead due to in extremis consumption of shared cache memory resources. Consequently, vRAN suffers from increased energy consumption, which fuels the already high operational costs in 5G networks. This paper investigates cache memory allocation mechanisms' effectiveness in reducing total energy consumption. Using an experimental vRAN platform, we profile the energy consumption and CPU utilization of vBS as a function of the network state (e.g., traffic demand, modulation scheme). Then, we address the high dimensionality of the problem by decomposing it per vBS, which is possible thanks to the Last-Level Cache (LLC) isolation implemented in our system. Based on this, we train a vBS digital twin, which allows us to train offline a classifier, avoiding the performance degradation of the system during training. Our results show that our approach performs very closely to an offline optimal oracle, outperforming standard approaches used in today's deployments.
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- 2024
48. Formalizing Factorization on Euclidean Domains and Abstract Euclidean Algorithms
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de Lima, Thaynara Arielly, Avelar, Andréia Borges, Galdino, André Luiz, and Ayala-Rincón, Mauricio
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Computer Science - Logic in Computer Science - Abstract
This paper discusses the extension of the Prototype Verification System (PVS) sub-theory for rings, part of the PVS algebra theory, with theorems related to the division algorithm for Euclidean rings and Unique Factorization Domains that are general structures where an analog of the Fundamental Theorem of Arithmetic holds. First, we formalize the general abstract notions of divisibility, prime, and irreducible elements in commutative rings, essential to deal with unique factorization domains. Then, we formalize the landmark theorem, establishing that every principal ideal domain is a unique factorization domain. Finally, we specify the theory of Euclidean domains and formally verify that the rings of integers, the Gaussian integers, and arbitrary fields are Euclidean domains. To highlight the benefits of such a general abstract discipline of formalization, we specify a Euclidean gcd algorithm for Euclidean domains and formalize its correctness. Also, we show how this correctness is inherited under adequate parameterizations for the structures of integers and Gaussian integers., Comment: In Proceedings LSFA/HCVS 2023, arXiv:2404.13672
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- 2024
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49. Reducing hallucination in structured outputs via Retrieval-Augmented Generation
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Béchard, Patrice and Ayala, Orlando Marquez
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence ,Computer Science - Computation and Language ,Computer Science - Information Retrieval - Abstract
A common and fundamental limitation of Generative AI (GenAI) is its propensity to hallucinate. While large language models (LLM) have taken the world by storm, without eliminating or at least reducing hallucinations, real-world GenAI systems may face challenges in user adoption. In the process of deploying an enterprise application that produces workflows based on natural language requirements, we devised a system leveraging Retrieval Augmented Generation (RAG) to greatly improve the quality of the structured output that represents such workflows. Thanks to our implementation of RAG, our proposed system significantly reduces hallucinations in the output and improves the generalization of our LLM in out-of-domain settings. In addition, we show that using a small, well-trained retriever encoder can reduce the size of the accompanying LLM, thereby making deployments of LLM-based systems less resource-intensive., Comment: To be presented at NAACL 2024. 11 pages and 4 figures
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- 2024
50. First Eigenvalue Estimates for Asymptotically Hyperbolic Manifolds and their Submanifolds
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Pérez-Ayala, Samuel and Tyrrell, Aaron J.
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Mathematics - Differential Geometry ,Mathematics - Spectral Theory - Abstract
We derive a sharp upper bound for the first eigenvalue $\lambda_{1,p}$ of the $p$-Laplacian on asymptotically hyperbolic manifolds for $1
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- 2024
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