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9. Tedaviye Dirençli Temporal Lob Epilepsili Olgularda Serum ve Bos’ta Otoantikorlar: Olgu Serisi

Author

CANBAZ KABAY, Sibel, TÜZÜN, Erdem, AKDAĞ, Gönül, ÇETİNER, Mustafa, AYAS, Selahattin, ÖZIŞIK KARAMAN, Handan Işın, and AKKOYUN ARIKAN, Fatma

Subjects
Health Care Sciences and Services, Temporal lobe epilepsy, cerebrospinal fluid neuronal antibody, serum neuronal antibody, General Medicine, Sağlık Bilimleri ve Hizmetleri, Temporal lob epilepsisi, beyin omurilik sıvısı nöronal antikoru, serum nöronal antikor
Abstract

Nöbet önleyici ilaca(NÖİ) dirençli temporal lob epilepsili hastaların serum ve beyin omurilik sıvısı (BOS) analizinde nöronal antikor varlığını araştırmayı amaçladık. İlaca dirençli temporal lob epilepsisi tanısı ile izlenen, lomber ponksiyonu kabul eden 8 hastayı değerlendirdik. İlaca dirençli temporal lob epilepsisi nedeniyle takip ettiğimiz ve otoimmün epilepsi şüphesi duyduğumuz olgularda nöronal antikorları ve klinik özellikleri araştırdık. Tüm hastalarda hem serum hem de BOS'ta nöronal otoantikorlar negatif bulundu. BOS ve serum incelemelerinde nöronal antikorlar saptanmasa da bu durum çalışma grubumuzda epilepsi başlangıç yaşının erken olması ile ilişkili olabilir. Subakut bir klinik, nöbet sıklığının alışılmadık derecede yüksek olması, nöbetlerin çeşitliliği ve değişkenliği, NÖİ’lara direnç, kişide veya ailesinde otoimmün hastalık varlığı, kanser öyküsü veya viral prodrom varlığı, santral sinir sistemi inflamasyonun gösterilmesi, nöral antikorların varlığında Otoimmün epilepsi ayırıcı tanıda düşünülmelidir., We aimed to investigate the presence of neuronal antibodies in serum and cerebrospinal fluid(CSF) analysis of patients with drug resistant temporal lobe epilepsy. We evaluated 8 patients who accepted lumbar puncture with a diagnosis of drug resistant temporal lobe epilepsy. Neuronal autoantibodies were found to be negative in both serum and CSF in all patients. We investigated neuronal antibodies and clinical features in cases who were followed up for drug-resistant temporal lobe epilepsy and suspected of autoimmune epilepsy. Although neuronal antibodies were not detected in CSF and serum examinations, this may be related to the early age of onset in our study group. Autoimmune epilepsy should be considered among the differantial diagnosis with a subacute clinic, unusually high seizure frequency, variety and variability of seizures, resistance to antiseizure medications(ASMs), presence of an autoimmune disease in the person or his/her family, history of cancer or viral prodroma, demonstration of CNS inflammation and detection of neural antibodies.

Published
2022
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11. TH-153. Clinical and electrophysiological characteristics of Guillain-Barré Syndrome before and during the pandemic: The multicenter Istanbul study

Author

Görkem Sirin, Nermin, primary, Tasdemir, Volkan, additional, Cakar, Arman, additional, Culha, Ayla, additional, Soysal, Aysun, additional, Deniz Elmali, Ayse, additional, Gündüz, Aysegül, additional, Yalcin, Destina, additional, Atakli, Dilek, additional, Kocasoy Orhan, Elif, additional, Tüzün, Erdem, additional, Gözke, Eren, additional, Gürsoy, Esra, additional, Karaali Savrun, Feray, additional, Ilgen Uslu, Ferda, additional, Aysal, Fikret, additional, Durmus, Hacer, additional, Bülbül, Hafsa, additional, Ertas, F.Inci, additional, Uluc, Kayıhan, additional, Tutkavul, Kemal, additional, Baysal, Leyla, additional, Baris Baslo, Mehmet, additional, Kiziltan, Meral, additional, Mercan, Metin, additional, Pazarci, Nevin, additional, Uzun, Nurten, additional, Akan, Onur, additional, Cokar, Ozlem, additional, Kahraman Koytak, Pinar, additional, Sürmeli, Reyhan, additional, Günaydin, Sefer, additional, Ayas, Selahattin, additional, Alpaydın Baslo, Sezin, additional, Yayla, Vildan, additional, Yilmaz, Vuslat, additional, Parman, Yesim, additional, Matur, Zeliha, additional, Unlüsoy Acar, Zeynep, additional, and Emre Oge, Ali, additional

Published
2022
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12. Abnormal Somatosensory Temporal Discrimination Is Not Related to Impaired Fine Motor Skills in Carpal Tunnel Syndrome.

Author

Aliş, Ceren, Ayas, Selahattin, Zileli, İsmail, Adatepe, Nurten Uzun, Savrun, Feray Karaali, and Gündüz, Ayşegül

Subjects
*CARPAL tunnel syndrome, *FINE motor ability, *NERVE conduction studies, *SOMATOSENSORY cortex, *EFFERENT pathways
Abstract

Objective: Carpal tunnel syndrome has been shown to cause hand clumsiness, impairment in pinch grip force, and fine motor skills. We hypothesized that impaired fine motor skills in carpal tunnel syndrome may be related to maladaptive central somatosensory changes. This study aimed to investigate the relationship between the changes in central sensory pathways and fine motor activities in patients with carpal tunnel syndrome by examining the somatosensory temporal discrimination threshold. Methods: This study included 37 patients with idiopathic carpal tunnel syndrome and 19 healthy subjects. After recording routine nerve conduction studies, sensory threshold and somatosensory temporal discrimination threshold on volar faces of dominant second (2f) and fifth fingers (5f) were determined. All patients performed 9-hole peg test. We also questioned the presence of dropping objects. Results: Object dropping was more frequent in patients with idiopathic carpal tunnel syndrome in comparison to healthy subjects (P = .000). Duration to complete 9-hole peg test was also higher in patients with dropping objects. Although sensory threshold-2f and somatosensory temporal discrimination threshold-2f were higher in patients with carpal tunnel syndrome compared to healthy subjects, somatosensory temporal discrimination threshold-2f was not related to dropping objects. The duration of 9-hole peg test did not correlate with somatosensory temporal discrimination threshold-2f. Conclusion: We showed that there was a maladaptive reorganization process in primary somatosensory cortex of 2f represented by somatosensory temporal discrimination threshold in patients with carpal tunnel syndrome. Fine motor skills may be due to the disruption of superficial touch sensation or motor dysfunction secondary to carpal tunnel syndrome, but it is not related to maladaptive changes in somatosensory cortex-basal ganglia network represented by somatosensory temporal discrimination threshold. [ABSTRACT FROM AUTHOR]

Published
2023
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15. Cerebrospinal Fluid and Serum Autoantıbodıes in Drug-Resistant Temporal Lobe Epilepsıes: Case Series.

Author

Kabay, Sibel Canbaz, Tuzun, Erdem, Akdag, Gonul, Cetiner, Mustafa, Ayas, Selahattin, Karaman, Handan Ozisik, and Arikan, Fatma Akkoyun

Subjects
CEREBROSPINAL fluid, TEMPORAL lobe epilepsy, DRUG resistance, AUTOIMMUNE diseases, DIFFERENTIAL diagnosis
Abstract

Copyright of Osmangazi Journal of Medicine / Osmangazi Tip Dergisi is the property of Eskisehir Osmangazi University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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16. COVID-19 ENFEKSİYONU TAKİBİNDE UYKU BOZUKLUKLARI: TEK MERKEZ DENEYİMİ.

Author

Ayas, Selahattin and Uçan, Anıl

Abstract

Giriş: Bu çalışma, COVID-19 enfeksiyonu sonrası uyku ile ilişkili bozuklukları ve olası nedenlerini araştırmayı amaçlamaktadır. Gereç ve Yöntemler: Uyku ve Bozuklukları Ünitemize son 3 ayda başvuran, COVID-19 enfeksiyonu öyküsü olan, 18 yaş üstü hastaların verileri, anamnez, laboratuvar, görüntüleme ve polisomnografi incelemelerinden geriye dönük olarak elde edildi. Hastaların Pittsburgh uyku kalite indeksi (PUKI), Epworth uykululuk skalası ve Beck anksiyete envanteri (BAE) testleri verileri çalışmaya dahil edildi. Bulgular: COVID-19 enfeksiyonu sonrası tüm hastaların Uyku ve Bozuklukları Ünitemize başvuru nedeni insomni yakınmaları idi. Hastaların %64'ünde uyku ile ilişkili başka bir bozukluk saptanmıştır (Obstrüktif Uyku Apne Sendromu (OUAS) %52 ile en sık görülenidir). Kronik kardiyorespiratuar, serebral, endokrin-metabolik hastalık öyküsü, insomni yakınmalarına eşlik eden uyku ile ilişkili başka bir bozukluğu olan hastalarda anlamlı olarak daha yüksekti (%68'e karşı %0, p=0.001). Ayrıca, bu hastalarda hastaneye yatış öyküsü istatistiksel olarak anlamlı olmasa da daha yüksekti (%50'ye karşı %11, p=0.088). Tüm hastalar için medyan BAE değeri ve ortalama PUKI değeri yüksekti (sırasıyla 13 ve 11.6) ancak aralarında bir korelasyon bulunamadı (p=0.336). Sonuç: COVID-19 enfeksiyonu sonrası en sık uyku ile ilgili başvuru nedeni insomni yakınmaları olup kronik kardiyorespiratuar, serebral, endokrin-metabolik hastalık öyküsü ve/veya COVID-19 enfeksiyonu nedeniyle hastaneye yatış öyküsü mevcutsa OUAS başta olmak üzere eşlik eden uyku ilişkili başka bir bozukluk araştırılmalıdır. Ayrıca insomni yakınmalarının bir nedeni olarak anksiyete bozukluğunun şiddeti uyku kalitesinde bozulma ile korele değildir. [ABSTRACT FROM AUTHOR]

Published
2022

21. A Case of Iatrogenic Wernicke Encephalopathy Following Prolonged Total Parenteral Nutrition

Author

Çetiner, Mustafa, Dumlupınar Üniversitesi Tıp Fakültesi, Nöroloji Anabilim Dalı, Kütahya, Türkiye, Canbaz Kabay, Sibel, Ocak, Özgül, Çanakkale Devlet Hastanesi, Nöroloji Kliniği, Çanakkale, Türkiye., and Ayas, Selahattin

Subjects
Wernicke ensefalopatisi,total paranteral nutrisyon,tiamin eksikliği, Wernicke encephalopathy,total parenteral nutrition,thiamine deficiency
Abstract

Tiamin (Vitamin B1) glikoz metabolizmasında rol alan suda çözünen bir vitamindir. Eksikliğinde kardiyovasküler sistem ve sinir sistemi etkilenir. Wernicke ensefalopatisi, klinik olarak okulomotor anormallikler, ataksi ve mental durum değişikleri ile karekterize tiamin eksikliğinden kaynaklanan bir ensefalopati tablosudur. En sık olarak kronik alkol bağımlılarında görülmektedir. Uzun süre total parenteral nütrisyon desteği alan hastalarda da gelişebilmektedir. Yazımızda larenks kanseri nedeniyle opere olan, uzun süre yoğun bakımda kalan, oral beslenememesi nedeniyle total parenteral nütrisyon desteği alan ve Wernicke ensefalopatisi tanısı konularak nöroloji yoğun bakıma alınan 50 yaşında erkek hasta sunulmuştur., Thiamine is a water-soluble vitamin that plays a role in the metabolism of glucose. Thiamine deficiency affects cardiovascular and nervous systems. Wernicke encephalopathy is characterized by oculomotor abnormalities, ataxia and cognitive deterioration caused by thiamine deficiency. It is most commonly observed in chronic alcoholics. It may also occur in patients who receive long-term total parenteral nutrition. In this study, we present the case of a 50-year-old male patient who underwent surgery for laryngeal cancer, who stayed in the intensive care unit for a prolonged period and received total parenteral nutrition because of the inability of oral intake.

Published
2018

27. Abnormal Somatosensory Discrimination in Dry Eye Syndrome.

Author

Kızıltan, Meral Erdemir, Doğan, Cezmi, Ayas, Selahattin, and Gündüz, Ayşegül

Subjects
ELECTRODES, DRY eye syndromes, BLEPHAROSPASM, DISCRIMINATION (Sociology), PATHOLOGICAL physiology, HEALTH outcome assessment, ELECTROPHYSIOLOGY, COMPARATIVE studies, BLINKING (Physiology), OPHTHALMOLOGY, SOMATOSENSORY disorders, DISEASE complications
Published
2023
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28. Multipl skleroz hastalarında talamik volüm ile kognitif fonksiyon arasındaki korelasyonun değerlendirilmesi

Author

Ayas, Selahattin, Canbaz Kabay, Sibel, and Nöroloji Ana Bilim Dalı

Subjects
Multiple sclerosis, Nöroloji, Cognition, Cognition disorders, Neurology, Thalamus, Neurocognitive functions, Correlation
Abstract

Multipl Skleroz (MS) hem gri hem de ak maddenin etkilendiği santral sinir sisteminin inflamasyon, demiyelinizasyon, aksonal kayıp, gliozisi ile karakterize, farklı klinik gidiş ve nörolojik bulguların görüldüğü kronik inflamatuar ve nörodejeneratif bir hastalığıdır.MS'te başlangıç yaşı hastaların 2/3 ünde 20-40 yaş arasında olup erkek/kadın oranı 2-3/1'dir. Etyolojisi hala kesin olarak bilinmemekle birlikte genetik ve çevresel süreçlerin tetiklediği otoimmün mekanizmaların patogenezde rol aldığı düşünülmektedir. Histopatolojisinde aksonların kısmen korunduğu demiyelinizasyon, inflamasyon, oligodendrosit kaybı ve gliozis ile giden patolojik süreç hakim olup son zamanlarda yapılan çalışmalarda normal görülen ak madde ve gri maddede de trakt spesifik patern yanı sıra inflamasyon alanındaki başlıca TH1, TH17 ve aktive mikroglialardan salınan sitokin, nitrit oksit gibi mediatörler ile birlikte aktive mikrogliaların direkt olarak yol açtığı hasar saptanmıştır. Talamus kortikal ve subkortikal alanlar arasında resiprokal iletişimde önemli bir yapı olup özellikle başta anterior ve dorsomedial nükleuslarının MS hastalarında etkilenmesi kognitif bozuklukla yakından ilişkilidir. MS hastalarında kognitif bozukluk %35-60 oranında görülmekte olup bu bozukluk özellikle dikkat, bellek ve yürütücü fonksiyon alanlarında olmaktadır. Çalışmaya Dumlupınar Üniversitesi Tıp Fakültesi Evliya Çelebi Eğitim Araştırma Hastanesi Nöroloji Anabilim Dalı'nda takipli son 3 ay içinde (Aralık 2015- Mart 2016) MRG'si yapılan, revize 2010 McDonald kriterlerine göre RRMS tanısı almış, 20-50 yaş arasında, sekonder sebeplere ve depresyona bağlı kognitif disfonksiyonu ve son 3 ay içinde akut relaps öyküsü olmayan ve/veya intravenöz yüksek doz kortikosteroid tedavisi almayan 36 hasta ile son 3 ay içinde baş ağrısı nedeniyle nöroloji polikliniğine başvuran nörolojik muayene ve MRG'si normal olan, sekonder sebeplere ve depresyona bağlı kognitif etkilenmesi olmayan 23 sağlıklı birey alındı. Hasta ve kontrol grubuna dikkat, bellek, yürütücü fonksiyonlar, dil ve vizyospasyal alanlara yönelik nöropsikometrik testler uygulandı. Kontrol grubu ile karşılaştırıldığında ortalama hastalık süresi 2 yıl ve ortalama EDSS'si 2 olan erken evre RRMS hastalarında literatürle uyumlu olarak dikkat, bellek ve yürütücü fonksiyonlar alanlarında belirgin etkilenme olup bu etkilenme talamik alan ve korpus kallosum alanındaki azalma ve 3. ventrikül genişliğindeki artış ile korele olarak saptanmıştır. Kognitif rezervi düşük olan yani eğitim süresi 8 yılın altında olan MS hastalarında ise kognitif rezervi yüksek olanlara göre tüm kognitif alanlarda etkilenme saptanmıştır. Çalışmamız kognitif etkilenmenin görüntüleme yöntemleri ile erken dönemde değerlendirilebilmesi ve gelecekte derin gri madde etkilenimine yönelik önlemlerin hastalığın erken döneminden itibaren alınması yol gösterici olması amaçlamıştır. Multiple Sclerosis (MS) is an chronic inflammatory and neurodegenerative disease which affects both gray and white matter, and characterized by inflammation, demyelination, axonal loss and gliosis of the central nervous system, also it presents with different clinical courses and neurologic signs.In two third of the MS patients the age of onset is between 20-40 years. The male / female ratio is 2-3 / 1. Although it is not known with certainty about the etiology, is thought to be involved in the pathogenesis of autoimmune mechanisms triggered by genetic and environmental process. Histopathologically while the axons are partially protected, demyelination, inflammation is dominated by the pathological process leading to oligodendrocyte loss and gliosis.In recent studies the direct damage of activated microglia were identified as well as tract-specific patterns in normal working white and gray matter and with the release of mediators such as cytokines, nitrite oxide from Th1 TH17 and activated microglia in the inflammation area,Thalamus, is an important structure in reciprocal communication between cortical and subcortical areas. Which anterior and dorsomedial nuclei are affected in MS patients are closely related to cognitive impairment. The rate of cognitive impairment seen in 35-60% of MS patients, and especially attention, memory and executive functions are effected. 36 patients and 23 healthy subjects were enrolled in the study in Dumlupınar University Faculty of Medicine, Evliya Celebi Education and Research Hospital Neurology Department, whom had MR imagines in the last 3 months, and had been diagnosed with RRMS according to the revised 2010 McDonald criteria, between 20-50 years of age. The patients whom had secondary causes and depression linked with cognitive dysfunction, and acute relapse history in the last 3 months and/or high dose intravenous corticosteroid therapy were excluded from the study. Control group was consisted of 23 subjects whom admitted to the neurology clinic because of headache in the last 3 months with normal neurological examination and MRI also with normal cognitive function. Neuropsychometric test was performed to the patient and control groups, for the memory, executive functions, attention language, and visuospatial area. The mean disease duration of MS patients were 2 years and the average EDSS'S were 2. Compared with the control group, in accordance with the literature in the early stages of RRMS patients attention, memory and executive functions were significantly affected. This impairment was correlated with the decrease of the thalamic area, and the corpus callosum area, and also correlated with the increase in width of the ventricles. In patients whom had low cognitive reserve that means with a training period less than 8 years, all cognitive domains were affected than those with high cognitive reserve.Our study aims to highlight the importance of evaluating the cognitive impairment by imaging methods to assess the prevention of deep gray matter in the future in the early stage of the disease. 151

Published
2016

29. 9th International Congress on Psychopharmacology & 5th International Symposium on Child and Adolescent Psychopharmacology

Author

Şahmelikoğlu Onur, Özge, primary, Çukurova, Merve, additional, Bağ, Sevda, additional, Yalçın, Suat, additional, Çakır Şen, Cansu, additional, Karşıdağ, Çağatay, additional, Süleyman Can, Serdar, additional, Tuğçe Akçaer, Emine, additional, Taşdelen Kul, Ayşegül, additional, İspir, Mustafa, additional, Bakkal, Osman, additional, Algül, Ayhan, additional, Ebrinç, Servet, additional, Yükselir, Cihad, additional, Zincir, Serkan, additional, Öztürk, Pelin, additional, Karaahmetoğlu, Bülent, additional, Baş, Özlem, additional, Şahmelikoğlu Onur, Özge, additional, Ulukaya, Sema, additional, Soykan, Çağlar, additional, Çayköylü, Ali, additional, Yazar, Neslihan, additional, Başar Kocagöz, Zehra, additional, Özçetin, Adnan, additional, Bahar Ölmez, Safiye, additional, Ataoğlu, Ahmet, additional, Hasan Balcioglu, Yasin, additional, Demir Berkol, Tonguc, additional, Ekim Cevik, Filiz, additional, Oncu, Fatih, additional, Ozgen, Guliz, additional, Demiröz, Dudu, additional, Yardım Özayhan, Hatice, additional, Seven, Hilal, additional, Çağrı Yıldız, Mustafa, additional, Başaran, Recep, additional, Eren, İbrahim, additional, Özlem Canazlar, Elif, additional, Sevinçok, Levent, additional, Doğan, Bilge, additional, Öykü Memiş, Çağdaş, additional, Baran Tanrikulu, Ali, additional, İnanli̇, İkbal, additional, Çağri̇ Yi̇ldi̇z, Mustafa, additional, Şerife Elmas, Tuba, additional, Eren, Ibrahim, additional, Alperen Korkmaz, Şükrü, additional, Pınar Şen, Cansu, additional, Fatih Ceylan, Mehmet, additional, Hesapçıoğlu, Selma Tural, additional, Bakar, Burcu, additional, Tuncer, Can, additional, Yeni Elbay, Rümeysa, additional, Görmez, Aynur, additional, Tokgöz, Yusuf, additional, Bolu, Abdullah, additional, Çelik, Cemil, additional, Uzun, Özcan, additional, Kirlioglu, Simge Seren, additional, Balcioglu, Yasin Hasan, additional, Aydin, Pinar Cetinay, additional, Uğurlu, Mustafa, additional, Uğurlu, Görkem Karakaş, additional, Akçaer, Emine Tuğçe, additional, Can, Serdar Süleyman, additional, Koç, Zuhal, additional, Kapubağlı, Nazlı, additional, Tuncer, Ömer Faruk, additional, Ünlü, Gülsen, additional, Şahin, Esra Kabadayı, additional, Apaydın, Zuhal Koç, additional, Kaymak, Semra Ulusoy, additional, Peker, Oğuz, additional, Özkan, Bedriye, additional, Kılıçoğlu, Ali Güven, additional, Karaçetin, Gül, additional, Yücehan, Zeynep, additional, Elmas, Tuğba Şerife, additional, Yağlı, Nafiye, additional, İlhan, Bilge Çetin, additional, Aker, Derya Adali, additional, Kıvılcım, Yiğit, additional, Solmaz, Mustafa, additional, Kutlu, Yeşim Ruhat, additional, Yeşil, Bahar, additional, Almış, Behice Han, additional, Küçük, Başak, additional, Cerit, Cem, additional, Sarici, Burcu, additional, Kaypak, Ayşe Ceren, additional, Baysak, Erensu, additional, Ergün, Serhat, additional, Yildiz, Mesut, additional, Ibiloglu, Aslihan Okan, additional, Atli, Abdullah, additional, Asoglu, Mehmet, additional, Ozkan, Mustafa, additional, Memik, Nursu Çakın, additional, Ünver, Hatice, additional, Gündoğdu, Özlem Yıldız, additional, Uzun, Necati, additional, Akça, Ömer Faruk, additional, Aral, Gizem, additional, Aykut, Demet Sağlam, additional, Maden, Özgür, additional, Gündoğmuş, İbrahim, additional, Gok, Fulya, additional, Kiraz, Seda, additional, Cipil, Arif, additional, Eroglu, Meliha Zengin, additional, Çiftçi, Elvan, additional, Aslan, Zeynep, additional, Gül, Melike Kevser, additional, Taştepe, Neslihan, additional, Demirci, Esra, additional, Özmen, Sevgi, additional, Doğru, Hicran, additional, Karayağmurlu, Elif, additional, Karayağmurlu, Ali, additional, Göksu, Muhsine, additional, Tügen, Leyla Ezgi, additional, Ayaz, Ayşe Burcu, additional, Arman, Ayşe, additional, Özayhan, Hatice Yardım, additional, Altunova, Deniz, additional, Yıldız, Mustafa Çağrı, additional, Atagün, Murat İlhan, additional, Kul, Ayşegül Taşdelen, additional, Güldaş, Ekrem, additional, Göl, Güler, additional, Savcı, Uğur, additional, Tufan, Ali Evren, additional, Özbek, Seda Yıldırım, additional, Özbek, Süleyman, additional, Uygur, Hilal, additional, Demirel, Başak, additional, Esra Çiçek, İ., additional, Kara, Hüseyin, additional, Balcı, Mehmet Murat, additional, Karaca, Servet, additional, Kuloğlu, Mehmet Murat, additional, Aytaç, Hasan Mervan, additional, Ger, Mehmet Can, additional, İbiloğlu, Aslıhan Okan, additional, Asoğlu, Mehmet, additional, Çakır, Ayşe, additional, Tiryaki, Ahmet, additional, Çelme, Gülşah Güçlü, additional, Boztaş, Mehmet Hamid, additional, Sırmatel, Fatma, additional, Erdogan, Mucahid, additional, Dayan, Cengiz, additional, Atakli, Hayrunisa Dilek, additional, Kartalcı, Gülşen, additional, Yücel, Ebru, additional, Kartalcı, Şükrü, additional, Eroğlu, Meliha Zengin, additional, Çipil, Arif, additional, Çalışkan, Mecit, additional, Çavusoglu, Emine Cengiz, additional, Özdemir, Yusuf Özay, additional, Elmas, Tuba Şerife, additional, Fındıklı, Ebru, additional, Şahin, Berkan, additional, Karabekiroğlu, Koray, additional, Kurt, Mustafa, additional, Memiş, Çağdaş Öykü, additional, Sevinçok, Doğa, additional, Sertdemir, Merve, additional, Ay, Rukiye, additional, Yılmaz, Nevzat, additional, Demirkaya, Sevcan Karakoç, additional, Aksu, Hatice, additional, Gizem Gerçek, Hacer, additional, Karakoç, Gülser, additional, Altıntoprak, Ayşe Ender, additional, Coşkunol, Hakan, additional, Yazici, Ipek Percinel, additional, Utku Yazici, Kemal, additional, Altıntaş, Kevser, additional, Gök, Fulya, additional, Yaylacı, Ferhat, additional, Erkuran, Handan Özek, additional, Eyüboğlu, Murat, additional, Göverti, Diğdem, additional, Yüksel, Rabia Nazik, additional, Bülbül, Alper, additional, Aydemir, Makbule Çiğdem, additional, Göka, Erol, additional, Kınalı, Ilgaz, additional, Hacıoğlu, Münevver Yıldırım, additional, Sarıcı, Burcu, additional, Sayar, Kemal, additional, Doğan, Hatice, additional, Akay, Ömer, additional, Kim, Heecheol, additional, Lee, Hyunjoo, additional, Karagöz, Abdulkadir, additional, Kullakçı, Hakan, additional, 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Published
2017
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31. Long term sustained therapeutic effects of percutaneous posterior tibial nerve stimulation treatment of neurogenic overactive bladder in multiple sclerosis patients: 12-months results.

Author

Canbaz Kabay, Sibel, Kabay, Sahin, Mestan, Emine, Cetiner, Mustafa, Ayas, Selahattin, Sevim, Mehmet, Ozden, Hilmi, and Karaman, Handan Ozisik

Abstract

Aims The aim of this study is to determine the sustained therapeutic efficacy and treatment intervals for PTNS in NOAB with MS, offering periodic additional treatments during 1 year in patients who completed an initial course of 12 consecutive weekly sessions. Methods A total of 34 patients enrolled to the PTNS treatment and 21 patients completed the 1 year PTNS treatment with a tapering protocol of 6, 9, and 12 months of therapy, respectively. After 12 weeks of therapy, PTNS was applied at 14 day intervals for 3 months, 21 day intervals for 3 months, and 28 day intervals for 3 months. The patients completed a 3-day voiding diary at 3rd, 6th, 9th, and 12th month. The patients requested to complete validated questionnaires (ICIQ-SF, OAB-V8, OAB-q SF) were carried out within 3-month intervals thereafter during their enrolment in the study. Results A total of 21 patients were enrolled in the study. Of these 5 (23.8%) were men and 16 (76.2%) women. The improvements for all voiding diary parameters were significant in the 6th, 9th, and 12th months when compared with baseline. Mean values between baseline and 12 month parameters suggested that daytime frequency decreased by 5.4 voids daily, urge incontinence decreased by 3.4 episodes daily, urgency episodes decreased by 7.4 episodes daily, nocturia decreased by 2.6 voids, and voided volume improved by a mean of 72.1 cc. Conclusion These results have demonstrated NOAB symptom improvement in MS patients can be achieved with 12 weekly PTNS treatments which show excellent durability over 12 months. Neurourol. Urodynam. 36:104-110, 2017. © 2015 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]

Published
2017
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32. Re: The Clinical and Urodynamic Results of Percutaneous Posterior Tibial Nerve Stimulation on Neurogenic Detrusor Overactivity in Patients with Parkinson's Disease.

Author

Kabay, Şahin, Çetiner, Mustafa, Mestan, Emine, Sevim, Mehmet, Kabay, Sibel Canbaz, Ayas, Selahattin, Özden, Hilmi, and Karaman, Handan Özışık

Subjects
PARKINSON'S disease patients, PARKINSON'S disease treatment, TIBIAL nerve
Abstract

The article discusses Neurogenic Detrusor Overactivity (NDO) which affects patients with Parkinson's Disease (PD) and the therapeutic use of percutaneous Posterior Tibial Nerve Stimulation (PTNS) for PD patients.

Published
2015
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33. Electrodiagnostic methods to verify Guillain-Barré syndrome subtypes in Istanbul: A prospective multicenter study.

Author

Tasdemir V, Sirin NG, Cakar A, Culha A, Soysal A, Elmali AD, Gunduz A, Arslan B, Yalcin D, Atakli D, Orhan EK, Sanli E, Tuzun E, Gozke E, Gursoy E, Savrun FK, Uslu FI, Aysal F, Durmus H, Bulbul H, Ertas FI, Uluc K, Tutkavul K, Baysal L, Baslo MB, Kiziltan M, Mercan M, Pazarci N, Uzun N, Akan O, Cokar O, Koytak PK, Sürmeli R, Gunaydin S, Ayas S, Baslo SA, Yayla V, Yilmaz V, Parman Y, Matur Z, Acar ZU, and Oge AE

Subjects
Humans, Prospective Studies, Neural Conduction physiology, Electrodiagnosis methods, Gangliosides, Antibodies, Guillain-Barre Syndrome
Abstract

Background and Aims: This study aimed to identify the clinical characteristics and electrodiagnostic subtypes of Guillain-Barré syndrome (GBS) in Istanbul., Methods: Patients with GBS were prospectively recruited between April 2019 and March 2022 and two electrodiagnostic examinations were performed on each patient. The criteria of Ho et al., Hadden et al., Rajabally et al., and Uncini et al. were compared for the differentiation of demyelinating and axonal subtypes, and their relations with anti-ganglioside antibodies were analyzed., Results: One hundred seventy-seven patients were included, 69 before the coronavirus disease 2019 pandemic (April 2019-February 2020) and 108 during the pandemic (March 2020-March 2022), without substantial changes in monthly frequencies. As compared with the criteria of Uncini et al., demyelinating GBS subtype diagnosis was more frequent according to the Ho et al. and Hadden et al. criteria (95/162, 58.6% vs. 110/174, 63.2% and 121/174, 69.5%, respectively), and less frequent according to Rajabally et al.'s criteria (76/174, 43.7%). Fourteen patients' diagnoses made using Rajabally et al.'s criteria were shifted to the other subtype with the second electrodiagnostic examination. Of the 106 analyzed patients, 22 had immunoglobulin G anti-ganglioside antibodies (14 with the axonal subtype). They had less frequent sensory symptoms (54.5% vs. 83.1%, p = 0.009), a more frequent history of previous gastroenteritis (54.5% vs. 22.9%, p = 0.007), and a more severe disease as compared with those without antibodies., Interpretation: Serial electrodiagnostic examinations are more helpful for accurate subtype diagnosis of GBS because of the dynamic pathophysiology of the disease. We observed no significant increase in GBS frequency during the pandemic in this metropolis., (© 2024 Peripheral Nerve Society.)

Published
2024
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34. [Treatment approach to apnestic breathing in a patient with vocal cord paralysis due to Arnold Chiari malformation and tracheostomy].

Author

Ayas S, Benbir Şenel G, and Karadeniz D

Subjects
Adult, Arnold-Chiari Malformation complications, Arnold-Chiari Malformation diagnosis, Humans, Male, Polysomnography, Sleep Apnea, Central diagnosis, Sleep Apnea, Central etiology, Sleep Stages, Tracheostomy, Vocal Cord Paralysis surgery, Arnold-Chiari Malformation surgery, Sleep Apnea, Central surgery, Sleep Wake Disorders etiology
Abstract

Arnold Chiari malformation (ACM) is herniation of brain stem structures, especially cerebellar tonsils, from the foramen magnum into the cervical spinal canal. Sleep-related respiratory disorders are reported at a higher rate in this patient group than the general population, at about 60-75%. A 43-year-old male patient was diagnosed with ACM type 1.5 at the center where he applied with complaints of weakness in the extremities, speech disorder and syncope triggered by coughing, and a decompression of posterior fossa (PFD) was applied to the patient. Since 2018, the apnea attacks, which were able to be 6-7 times a night every night, last in 30 seconds, with eyes open, inactivity and bruising, have started in the patient, so in all night-time polysomnography (PSG) examination for diagnostic purpose, apnestic breathing including continuous, central and mixed type apneas in sleep and wakefulness was detected. Different modes (CPAP, BPAP-S/T, ASV) were tried with the cannula placed on the tracheostomy in the PSG performed for non-invasive mechanical ventilation therapy, but none alone was effective. In the patient, whom IVAPS/AVAPS mode was tried, all abnormal breathing events, irregular apnetic breathing pattern and oxygen desaturations were effectively controlled in all positions, wakefulness and all sleep stages with pressure support, respiratory rate and tidal volume support. PFD is recommended as the first-line treatment for the treatment of obstructive or central type apneas in ACM; Information on non-invasive mechanical ventilation therapy is insufficient. In this case, we aimed to present the difficulties in the diagnosis and treatment of sleep-related respiratory disorders in a patient whom ACM diagnosed, PFD was applied but underwent permanent trachoestomy due to bilateral vocal cord paralysis.

Published
2020
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