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272 results on '"Ayatollahi, Seyed Abdulmajid"'

17. Flavonoids Isolated From Delphinium semibarbatum Flowering Aerial Parts With Their Antibacterial, Antibiofilm, and Antiswarming Activity Against Proteus mirabilis and Staphylococcus aureus.

Author

Lotfaliani, Mohammadreza, Ayatollahi, Seyed Abdulmajid, Kobarfard, Farzad, Majnooni, Mohammad Bagher, Mirzaei, Arezoo, Ghanadian, Mustafa, Farzaei, Mohammad Hossain, and Gutiérrez-Grijalva, Erick

Subjects
*METHOXY group, *QUERCETIN, *BIOACTIVE compounds, *STAPHYLOCOCCUS aureus, *CATHETER-associated urinary tract infections, *PHYTOCHEMICALS
Abstract

Proteus mirabilis and Staphylococcus aureus are pathogens associated with CAUTIs. Understanding their significance is crucial for effective prevention and treatment. In this study, the Delphinium semibarbatum flavonoid‐rich fraction (DSF) was analyzed, and its antibacterial, antibiofilm, and antiswarming properties against these two bacterial species were evaluated. In the phytochemical analysis, four flavonoids, including kaempferol, 4′‐O‐methyl quercetin, quercetin, and kaempferol‐3‐O‐beta‐D‐glucopyranoside (K3G), were isolated. The minimum inhibitory concentration (MIC50) of DSF on P. mirabilis and S. aureus was 1000 μg/mL. Similarly, kaempferol, K3G, and 4′‐O‐methyl quercetin exhibited inhibitory effects of 20%, 13%, and 12%, respectively, at a concentration of 1000 μg/mL compared to the P. mirabilis control. However, the MIC50 of kaempferol and 4′‐O‐methyl quercetin for S. aureus were 125 μg/mL and 62.25 μg/mL, respectively. K3G exhibited an inhibitory effect of 37% at a concentration of 1000 μg/mL. DSF reduced biofilm at 1 mg/mL by 78% and 74% for P. mirabilis and S. aureus, respectively. Quercetin was the most effective in inhibiting P. mirabilis biofilm formation, with a 96% inhibition rate, followed by kaempferol and K3G, with 67% and 29%, respectively, at the same concentration. The best bioactive compound against biofilm inhibition of S. aureus was quercetin at 250 μg/mL, exhibiting 90% inhibition, followed by K3G, 4′‐O‐methyl quercetin, and kaempferol with 81%, 45%, and 33%, respectively, at a concentration of 125 μg/mL. In the swarming inhibition assay, DSF showed 78% inhibition at concentrations of 5 μg/mL. Similarly, all bioactive compounds showed 45% antiswarming activity at this concentration. The docking results of the isolated flavonoids on two target proteins, SarA and MrpH, showed that the presence of the methoxy group in the structure of 4′‐O‐methyl quercetin reduced its interaction with these two proteins. In the ADMET prediction, isolated flavonoids showed good predicted properties suitable for treating these two microbial species in urinary infection diseases. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Propolis: An update on its chemistry and pharmacological applications

Author

Hossain, Rajib, Quispe, Cristina, Khan, Rasel Ahmed, Saikat, Abu Saim Mohammad, Ray, Pranta, Ongalbek, Damira, Yeskaliyeva, Balakyz, Jain, Divya, Smeriglio, Antonella, Trombetta, Domenico, Kiani, Roghayeh, Kobarfard, Farzad, Mojgani, Naheed, Saffarian, Parvaneh, Ayatollahi, Seyed Abdulmajid, Sarkar, Chandan, Islam, Mohammad Torequl, Keriman, Dılhun, Uçar, Arserim, Martorell, Miquel, Sureda, Antoni, Pintus, Gianfranco, Butnariu, Monica, Sharifi-Rad, Javad, and Cho, William C.

Published
2022
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28. Athyrium plants - Review on phytopharmacy properties

Author

Salehi, Bahare, Ezzat, Shahira M., Tsouh Fokou, Patrick Valere, Albayrak, Sevil, Vlaisavljevic, Sanja, Sharifi-Rad, Majid, Bhatt, Indra D., Sharifi-Rad, Mehdi, Belwal, Tarun, Ayatollahi, Seyed Abdulmajid, Kobarfard, Farzad, Ata, Athar, Baghalpour, Navid, Martorell, Miquel, Setzer, William N., and Sharifi-Rad, Javad

Published
2019
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30. Thymus spp. plants - Food applications and phytopharmacy properties

Author

Salehi, Bahare, Abu-Darwish, Mohammad Sanad, Tarawneh, Amer Hussein, Cabral, Celia, Gadetskaya, Anastassiya V., Salgueiro, Ligia, Hosseinabadi, Tahereh, Rajabi, Sadegh, Chanda, Warren, Sharifi-Rad, Mehdi, Mulaudzi, Rofhiwa Bridget, Ayatollahi, Seyed Abdulmajid, Kobarfard, Farzad, Arserim-Uçar, Dılhun Keriman, Sharifi-Rad, Javad, Ata, Athar, Baghalpour, Navid, and Contreras, María del Mar

Published
2019
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38. Wheat germ, a byproduct of the wheat milling industry, as a beneficial source of anti‐aging polyamines: A quantitative comparison of various forms.

Author

Mohajeri, Maryam, Ayatollahi, Seyed Abdulmajid, Kobarfard, Farzad, Goli, Mohammad, Khandan, Maryam, Mokhtari, Shaya, and Khodadoost, Mahmoud

Subjects
*WHEAT germ, *WHEAT trade, *FLOUR industry, *POLYAMINES, *AGING prevention, *GRAIN, *WHEAT
Abstract

Polyamines have received a lot of attention since the 1990s because of their anti‐aging, anti‐chronic disease, and proliferative effects. Wheat germ was reported as one of the natural sources of high polyamine, especially spermidine. The current study used three types of wheat germ: group A was industrially separated germ from whole grain, group B was the commercially available germinated wheat germ, and group C was manually separated wheat germ from germinated grain. The polyamine content of putrescine, spermidine, and spermine has been determined using a simplified isocratic LC–MS/MS method. An optimized extraction procedure was performed on all seven samples for obtaining a polyamine‐enriched extract. The three dominant carbomylated polyamines were identified by analyzing the extracted samples in order to determine their relative abundance. Wheat germ powders contain the highest amount of polyamines (220–337 μg/g) of which spermidine is one of the most important. Germinated wheat grains, on the other hand, contain the least amount of this polyamine. The commercially available separated wheat germs are suggested as a good nutrition source of these polyamines. [ABSTRACT FROM AUTHOR]

Published
2023
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42. Identification of potential regulatory long non-coding RNA-associated competing endogenous RNA axes in periplaque regions in multiple sclerosis

Author

Sabaie, Hani, primary, Khorami Rouz, Sharareh, additional, Kouchakali, Ghazal, additional, Heydarzadeh, Samaneh, additional, Asadi, Mohammad Reza, additional, Sharifi-Bonab, Mirmohsen, additional, Hussen, Bashdar Mahmud, additional, Taheri, Mohammad, additional, Ayatollahi, Seyed Abdulmajid, additional, and Rezazadeh, Maryam, additional

Published
2022
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49. Chemical Composition, Biological Activity, and Health-Promoting Effects of Withania somnifera for Pharma-Food Industry Applications

Author

Sharifi-Rad, Javad, primary, Quispe, Cristina, additional, Ayatollahi, Seyed Abdulmajid, additional, Kobarfard, Farzad, additional, Staniak, Mariola, additional, Stępień, Anna, additional, Czopek, Katarzyna, additional, Sen, Surjit, additional, Acharya, Krishnendu, additional, Matthews, Karl R., additional, Sener, Bilge, additional, Devkota, Hari Prasad, additional, Kırkın, Celale, additional, Özçelik, Beraat, additional, Victoriano, Montserrat, additional, Martorell, Miquel, additional, Rasul Suleria, Hafiz Ansar, additional, Alshehri, Mohammed M., additional, Chandran, Deepak, additional, Kumar, Manoj, additional, Cruz-Martins, Natália, additional, and Cho, William C., additional

Published
2021
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