1. Pediatric Bacterial Meningitis Surveillance in Nigeria From 2010 to 2016, Prior to and During the Phased Introduction of the 10-Valent Pneumococcal Conjugate Vaccine
- Author
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Joseph Nsiari-Muzeyi Biey, KM Yusuf, Sunday A Aderibigbe, BO Edelu, Iretiola Bamikeolu Fajolu, Peter Sylvanus Ndow, Chinonyerem J Ihuoma, Johnson Ticha, Dorothy Nwodo, Frances Udeinya, Muhammad Faruk Bashir, Fiona Braka, Namadi M Lawal, Florence Ndu, Folasade Ogunsola, Jimoh Yemi Abdulraheem, Ayodeji H Isiaka, Florian Gehre, Jason M. Mwenda, Archibald Worwui, Philomena Ogbogu, AO Saka, Velly Emina, Rowan E Bancroft, Adamu G Yusuf, Uchenna Chinedu Ozumba, Martin Antonio, Chinomnso Kanu, Brenda Kwambana-Adams, Ngozi Onyejiaka, Beckie N. Tagbo, Olusola P. Okunola, Mohammed Baba Abdulkadir, Olajumoke J Makinwa, and Abayomi Fadeyi
- Subjects
0301 basic medicine ,Microbiology (medical) ,Serotype ,medicine.medical_specialty ,business.industry ,Neisseria meningitidis ,030106 microbiology ,Outbreak ,medicine.disease_cause ,medicine.disease ,Pneumococcal conjugate vaccine ,Haemophilus influenzae ,Vaccination ,03 medical and health sciences ,0302 clinical medicine ,Infectious Diseases ,Internal medicine ,Streptococcus pneumoniae ,Medicine ,030212 general & internal medicine ,business ,Meningitis ,medicine.drug - Abstract
Background Historically, Nigeria has experienced large bacterial meningitis outbreaks with high mortality in children. Streptococcus pneumoniae (pneumococcus), Neisseria meningitidis (meningococcus), and Haemophilus influenzae are major causes of this invasive disease. In collaboration with the World Health Organization, we conducted longitudinal surveillance in sentinel hospitals within Nigeria to establish the burden of pediatric bacterial meningitis (PBM). Methods From 2010 to 2016, cerebrospinal fluid was collected from children Results A total of 5134 children with suspected meningitis were enrolled at the participating hospitals; of these 153 (2.9%) were confirmed PBM cases. The mortality rate for those infected was 15.0% (23/153). The dominant pathogen was pneumococcus (46.4%: 71/153) followed by meningococcus (34.6%: 53/153) and H. influenzae (19.0%: 29/153). Nearly half the pneumococcal meningitis cases successfully serotyped (46.4%: 13/28) were caused by serotypes that are included in the 10-valent pneumococcal conjugate vaccine. The most prevalent meningococcal and H. influenzae strains were serogroup W and serotype b, respectively. Conclusions Vaccine-type bacterial meningitis continues to be common among children
- Published
- 2019
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