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6 results on '"Ayotte, Ben D."'

1. The immune-related role of BRAF in melanoma

Author

Tomei, Sara, Bedognetti, Davide, De Giorgi, Valeria, Sommariva, Michele, Civini, Sara, Reinboth, Jennifer, Al Hashmi, Muna, Ascierto, Maria Libera, Liu, Qiuzhen, Ayotte, Ben D., Worschech, Andrea, Uccellini, Lorenzo, Ascierto, Paolo A., Stroncek, David, Palmieri, Giuseppe, Chouchane, Lotfi, Wang, Ena, and Marincola, Francesco M.

Published
2015
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2. An immunologic portrait of cancer

Author

Stroncek David F, Ayotte Ben D, Uccellini Lorenzo, Murtas Daniela, Spivey Tara L, Bedognetti Davide, Liu Qiuzhen, Giorgi Valeria De, Ascierto Maria, Chouchane Lotfi, Manjili Masoud H, Wang Ena, and Marincola Francesco M

Subjects
Medicine
Abstract

Abstract The advent of high-throughput technology challenges the traditional histopathological classification of cancer, and proposes new taxonomies derived from global transcriptional patterns. Although most of these molecular re-classifications did not endure the test of time, they provided bulk of new information that can reframe our understanding of human cancer biology. Here, we focus on an immunologic interpretation of cancer that segregates oncogenic processes independent from their tissue derivation into at least two categories of which one bears the footprints of immune activation. Several observations describe a cancer phenotype where the expression of interferon stimulated genes and immune effector mechanisms reflect patterns commonly observed during the inflammatory response against pathogens, which leads to elimination of infected cells. As these signatures are observed in growing cancers, they are not sufficient to entirely clear the organism of neoplastic cells but they sustain, as in chronic infections, a self-perpetuating inflammatory process. Yet, several studies determined an association between this inflammatory status and a favorable natural history of the disease or a better responsiveness to cancer immune therapy. Moreover, these signatures overlap with those observed during immune-mediated cancer rejection and, more broadly, immune-mediated tissue-specific destruction in other immune pathologies. Thus, a discussion concerning this cancer phenotype is warranted as it remains unknown why it occurs in immune competent hosts. It also remains uncertain whether a genetically determined response of the host to its own cancer, the genetic makeup of the neoplastic process or a combination of both drives the inflammatory process. Here we reflect on commonalities and discrepancies among studies and on the genetic or somatic conditions that may cause this schism in cancer behavior.

Published
2011
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3. The immune-related role of BRAF in melanoma

Author

Tomei, Sara, primary, Bedognetti, Davide, additional, De Giorgi, Valeria, additional, Sommariva, Michele, additional, Civini, Sara, additional, Reinboth, Jennifer, additional, Al Hashmi, Muna, additional, Ascierto, Maria, additional, Liu, Qiuzhen, additional, Ayotte, Ben D, additional, Worschech, Andrea, additional, Uccellini, Lorenzo, additional, Ascierto, Paolo A, additional, Stroncek, David, additional, Palmieri, Giuseppe, additional, Chouchane, Lotfi, additional, Wang, Ena, additional, and Marincola, Francesco M, additional

Published
2015
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4. The immune-related role of BRAF in melanoma

Author

Tomei, Sara, primary, Bedognetti, Davide, additional, De Giorgi, Valeria, additional, Sommariva, Michele, additional, Civini, Sara, additional, Reinboth, Jennifer, additional, Al Hashmi, Muna, additional, Ascierto, Maria Libera, additional, Liu, Qiuzhen, additional, Ayotte, Ben D., additional, Worschech, Andrea, additional, Uccellini, Lorenzo, additional, Ascierto, Paolo A., additional, Stroncek, David, additional, Palmieri, Giuseppe, additional, Chouchane, Lotfi, additional, Wang, Ena, additional, and Marincola, Francesco M., additional

Published
2014
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5. Longitudinal Study of Recurrent Metastatic Melanoma Cell Lines Underscores the Individuality of Cancer Biology

Author

Pos, Zoltan, primary, Spivey, Tara L., additional, Liu, Hui, additional, Sommariva, Michele, additional, Chen, Jinguo, additional, Wunderlich, John R., additional, Parisi, Giulia, additional, Tomei, Sara, additional, Ayotte, Ben D., additional, Stroncek, David F., additional, Malek, Joel A., additional, Robbins, Paul F., additional, Rivoltini, Licia, additional, Maio, Michele, additional, Chouchane, Lotfi, additional, Wang, Ena, additional, and Marincola, Francesco M., additional

Published
2014
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6. An immunologic portrait of cancer

Author

Ascierto, Maria Libera, primary, Giorgi, Valeria De, additional, Liu, Qiuzhen, additional, Bedognetti, Davide, additional, Spivey, Tara L, additional, Murtas, Daniela, additional, Uccellini, Lorenzo, additional, Ayotte, Ben D, additional, Stroncek, David F, additional, Chouchane, Lotfi, additional, Manjili, Masoud H, additional, Wang, Ena, additional, and Marincola, Francesco M, additional

Published
2011
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