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Background. The true causes of mortality and risk factors for pneumonia caused by COVID-19 require detailed analysis. Purpose: to clarify the risk factors for death in pneumonia caused by the SARS-CoV-2 virus. Materials and methods. A total of 196 patients with pneumonia of coronavirus etiology were examined. The observation group consisted of 68 patients with a lethal outcome, the comparison group consisted of 128 patients discharged with improvement. The assessment of the significance of risk factors for death was carried out by determining the magnitude of the relative risk and the etiological fraction. The results of the study were subjected to statistical processing with the calculation of the mean values, errors of the mean values, the criterion of reliability of the Student’s indicators (t). Results. The likelihood of death in patients with pneumonia caused by COVID-19 increases with increasing age of patients, living in the city, with pro-longed persistence of febrile syndrome, the need for re-hospitalization and transfer to the intensive care unit, and a large amount of damage. Respiratory failure of the III degree, renal failure, pleurisy, toxic liver damage, hematomas of various localization increase the risk of death. The course of COVID-19 infection is aggravated by chronic heart failure, coronary heart disease, diabetes mellitus, and chronic obstructive pulmonary disease. Laboratory predictors of an unfavorable outcome are cytopenia (lymphopenia, thrombocytopenia, anemia), a significant increase in ESR, CRP, D-dimer. Conclusion. Timely identification and consideration of risk factors for death will make it possible to adjust the volume of treatment measures in order to improve the prognosis for the life of patients with COVID-19-associated pneumonia. © 2021, Science and Innovation Center Publishing House. All rights reserved.