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3. Infliximab monitoring in Crohn’s disease: a neural network approach for evaluating disease activity and immunogenicity

Author

Gomes, Luis Eduardo Miani, primary, Genaro, Livia Moreira, additional, Castro, Marina Moreira de, additional, Ricci, Renato Lazarin, additional, Pascoal, Livia Bitencourt, additional, Silva, Filipe Botto Crispim, additional, Bonfitto, Pedro Henrique Leite, additional, Camargo, Michel Gardere, additional, Corona, Ligiana Pires, additional, Ayrizono, Maria de Lourdes Setsuko, additional, Azevedo, Anibal Tavares de, additional, and Leal, Raquel Franco, additional

Published
2024
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5. Ferric carboxymaltose for anemia in Crohn’s disease patients at a tertiary center: A retrospective observational cohort study

Author

Siqueira, Natália Souza Nunes, primary, Pascoal, Livia Bitencourt, additional, Rodrigues, Bruno Lima, additional, de Castro, Marina Moreira, additional, Martins, Alan Sidnei Corrêa, additional, Araújo, Dante Orsetti Silva, additional, Gomes, Luis Eduardo Miani, additional, Camargo, Michel Gardere, additional, Ayrizono, Maria de Lourdes Setsuko, additional, and Leal, Raquel Franco, additional

Published
2023
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13. MODELOS MATEMÁTICOS E NOVOS BIOMARCADORES DE RECIDIVA NO PÓS-OPERATÓRIO DE PACIENTES COM DOENÇA DE CROHN – ESTUDO TRANSCRICIONAL DO TECIDO ADIPOSO MESENTERIAL

Author

Steigleder, Karine Mariane, additional, Pascoal, Lívia Bitencourt, additional, Simino, Laís Angélica de Paula, additional, Siqueira, Natália Souza Nunes, additional, Ayrizono, Maria de Lourdes Setsuko, additional, de Azevedo, Aníbal Tavares, additional, Torsoni, Adriana Souza, additional, and Leal, Raquel Franco, additional

Published
2022
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22. Anti-TNF therapy and immunogenicity in inflammatory bowel diseases: a translational approach

Author

Genaro, Lívia Moreira, Gomes, Luís Eduardo Miani, Franceschini, Ana Paula Menezes de Freitas, Ceccato, Hugo Dugolin, de Jesus, Rafael Nascimento, Lima, Amanda Pereira, Nagasako, Cristiane Kibune, Fagundes, João José, Ayrizono, Maria de Lourdes Setsuko, and Leal, Raquel Franco

Subjects
Original Article
Abstract

Inflammatory bowel diseases are chronic illnesses that involve intestinal inflammation and are usually diagnosed as Crohn's disease or ulcerative colitis. As these diseases do not have a cure, the goal of treatment is to induce and maintain remission. Monoclonal antibodies have been recognized as the most advanced therapy to avoid complications and reduce the need for surgical approaches. However, although their effectiveness has been proven by several studies, they can trigger the immune system, induce the occurrence of immunogenicity, which may lead to the loss of response and treatment failure. The purpose of this review is to determine what are the main mechanisms involved in IBD; to assess the recommended treatments; to explore the mechanisms of immunogenicity. We also try to explain the detection and describe the existing advances that make possible the clinical application of these approaches.

Published
2021

24. Plastias de estenoses jejunais, ileais e ileocecais na doença de Crohn

Author

Ayrizono, Maria de Lourdes Setsuko, 1962, Fagundes, João Jose, 1943, Coy, Claudio Saddy Rodrigues, 1961, Andreollo, Nelson Adami, Souza, Virginio Candido Tosta de, Lopes, Luis Roberto, Saad, Luiz Henrique Cury, Universidade Estadual de Campinas. Faculdade de Ciências Médicas, Programa de Pós-Graduação em Cirurgia, and UNIVERSIDADE ESTADUAL DE CAMPINAS

Subjects
Cirurgia, Doença de Crohn, Constrição patológica, Intestinos - Doenças, Surgery, Crohn's diseases, Stricture, Inflamatory bowel disease
Abstract

Orientadores: João Jose Fagundes, Claudio Saddy Rodrigues Coy Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas Resumo: Plastia intestinal é uma alternativa cirúrgica no tratamento da estenose da doença de Crohn, principalmente em doentes com ressecções intestinais prévias ou múltiplos segmentos acometidos. O objetivo do trabalho consistiu na análise retrospectiva das complicações e do seguimento dos doentes operados por esta técnica. Foram estudados 28 doentes com estenoses do intestino delgado, ileocecais ou em anastomoses ileocólicas, submetidos à plastias intestinais, no período de setembro de 1991 a maio de 2004, pelo Serviço de Coloproctologia, da Disciplina de Moléstias do Aparelho Digestivo da UNICAMP. Dezesseis doentes (57,1%) eram do sexo masculino, com média etária de 33,3 anos (16-54). Dezesseis tinham antecedente de cirurgia para doença de Crohn, sendo em 13, ressecções intestinais. Foram realizadas 116 plastias (média de 4,1/doente), sendo 94 (81%) à Heineke-Mikulicz, 15 (13%) à Finney e sete (6%) ileocoloplastias látero-Iaterais. Três doentes foram submetidos a plastias em dois procedimentos cirúrgicos e dois, em três cirurgias. Dezoito doentes (64,3%) realizaram ressecções intestinais concomitantes à plastia, sendo 15 enterectomias (53,6%), duas ileotiflectomias (7,1%) e uma enterectomia associada à ileotiflectomia (3,6%). Foram observadas 14 complicações em sete doentes (25%), e um óbito (3,6%). Ocorreram duas complicações gerais (14,3%), em dois doentes (7,1%) e oito complicações locais precoces (57,1%), em sete doentes (25%). Ocorreram três deiscências de plastias (10,7% dos doentes), mas analisando-se por plastias realizadas, este índice foi de 2,6% (3/116). Dois doentes (7,1%), apresentaram peritonite não relacionada a plastia, sendo uma por lesão inadvertida de alça de delgado e outra secundária à deiscência da anastomose ileocólica. Foram observadas ainda, duas infecções da ferida operatória (14,3%), em dois doentes (7,1%), e uma hemorragia digestiva (3,6%). Complicações locais tardias foram em número de quatro (28,6%), em dois doentes (7,1%). Ambos apresentaram associação de hérnia incisional e fístula êntero-cutânea. O tempo médio de internação foi de 12,4 dias. No seguimento médio de 58,1 meses, 17 doentes (63%), apresentaram recidiva das cólicas abdominais, após três a 48 meses das plastias e dois doentes (7,4%), evoluíram com fistulas êntero-cutâneas, após dois e 19 meses, respectivamente. Onze doentes (40,7%) foram submetidos a novas cirurgias para realização de outras plastias ou ressecções intestinais, sendo que dois deles foram reoperados duas vezes e um, três vezes. Observaram-se quatro recidivas (3,5%) em local de plastia prévia, em três doentes (11,1%). Das recidivas, três (20%), foram na plastia do tipo Finney e uma no Heineke-Mikulicz (1,1%). Atualmente, 19 doentes estão assintomáticos ou oligossintomáticos, a grande maioria com uso de medicação. Em conclusão, as plastias apresentam baixos índices de complicações, principalmente no quesito deiscência, apesar das suturas serem realizadas no intestino doente. Pode-se inferir ainda que propiciam alívio dos sintomas. Uma vez que muitos doentes com doença de Crohn necessitarão de várias cirurgias ao longo da vida, as plastias constituem uma alternativa eficaz, pois podem aliviar os sintomas obstrutivos e também evitar ressecções intestinais extensas e suas conseqüências Abstract: Strictureplasty is an altemative surgical procedure for Crohn' s disease, particulary in patients with previous resections or many intestinal stenosis. The aim of this tudy was to analyze surgical complications and clinical follow-up in patients submitted to strictureplasty secondary to Crohn' s disease. Twenty-eight patients (57,1% male, mean age 33,3 years, range 16-54 years) with Crohn's disease and intestinal stenosis (small bowel, ileocecal region and ileocolic anastomosis) were submitted to strictureplasty,at one institution,betweenseptember1991and may2004. Sixteeenpatients had previous surgical procedures for Crohn's disease and 13 with intestinal resections. The mean follow-up was 58,1 months. A total of 116 strictureplasties were done (94 Heineke-Mikulicz - 81%, 15 Finney - 13%, seven side-to-side ileocolic strictureplasty - 6%). Three patients were submitted to strictureplasty at two different surgical procedures and two in three procedures. Regarding to strictureplasty, postoperative complication rate was 57,1%, with three suture leaks (10,7%) and late was present in two patients, both with incisional hemial and enterocutaneous fistulas (28,6%). Patients remainded hospitalized during a medium time of 12,4 days. Clinical and surgical recurrence rates were 63~ and 41%, respectively. Among the patients submitted to another surgery, two patients had two more operations and one had three. Recurrence rate at strictureplasty site was observed in 3,5%, being Finney techinique the commonest one. Presently, 19 patients had been asymptomatic with the majority of them under medical therapy. In conclusion, strictureplasties have low complicating rates, in spite of having been done at compromised site, with long term pain relief. Considering the clinical course of Crohn' s disease, with many patients being submitted to intestinal resections, strictureplasties should be considered as an effective surgical treatment to spare long intestinal resections Doutorado Cirurgia Doutor em Cirurgia

Published
2021

25. Role of diet and nutrition in inflammatory bowel disease

Author

de Castro, Marina Moreira, primary, Pascoal, Lívia Bitencourt, additional, Steigleder, Karine Mariane, additional, Siqueira, Beatriz Piatezzi, additional, Corona, Ligiana Pires, additional, Ayrizono, Maria de Lourdes Setsuko, additional, Milanski, Marciane, additional, and Leal, Raquel Franco, additional

Published
2021
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26. Microbiota-derived short-chain fatty acids do not interfere with SARS-CoV-2 infection of human colonic samples

Author

Pascoal, Lívia Bitencourt, primary, Rodrigues, Patrícia Brito, additional, Genaro, Lívia Moreira, additional, Gomes, Arilson Bernardo dos Santos Pereira, additional, Toledo-Teixeira, Daniel Augusto, additional, Parise, Pierina Lorencini, additional, Bispo-Dos-Santos, Karina, additional, Simeoni, Camila Lopes, additional, Guimarães, Paula Veri, additional, Buscaratti, Lucas Ildefonso, additional, Elston, João Gabriel De Angeli, additional, Marques-Souza, Henrique, additional, Martins-de-Souza, Daniel, additional, Ayrizono, Maria De Lourdes Setsuko, additional, Velloso, Lício Augusto, additional, Proenca-Modena, José Luiz, additional, Moraes-Vieira, Pedro Manoel Mendes, additional, Mori, Marcelo Alves Silva, additional, Farias, Alessandro Santos, additional, Vinolo, Marco Aurélio Ramirez, additional, and Leal, Raquel Franco, additional

Published
2021
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28. Contributors

Author

Algieri, Francesca, Almeida-Junior, Luiz Domingues de, Alves, Mariana da Rocha, Arruda, Henrique Silvano, Ayrizono, Maria de Lourdes Setsuko, Baptista, Rafaela de Carvalho, Bellinazzi, Levi Nascimento, Breves, Joana, Carvalho, Fabíola Vieira de, Ceccato, Hugo Dugolin, da Silva, Karina Nascimento, Di Stasi, Luiz Claudio, Dias, Cilene Bicca, Diez-Echave, Patricia, Esteves, Elizabethe Adriana, Ferreira, Marciane Milanski, Galvez, Julio, Genaro, Livia Moreira, Geraldi, Marina Villar, Gomes, Luis Eduardo Miani, Hidalgo-Garcia, Laura, Leal, Raquel Franco, Lima, Amanda Pereira, Lima, Dyana Carla, Fonseca Machado, Ana Paula da, Maia, Juliana Kelly da Silva, Marostica Junior, Mario Roberto, Martinez, Carlos Augusto Real, de Mello, Fábio Perez, Molina-Tijeras, Jose Alberto, de Moraes Malinverni, Andréa Cristina, Moreno, Lauane Gomes, Moura, Ludmilla David de, do Nascimento, Roberto de Paula, Noguera, Nathan Hargreaves, Orçati, Mariah Zajankauskas, Paiotti, Ana Paula Ribeiro, Pereira, José Aires, Polezi, Gabriele, Ramos, Cíntia Lacerda, Reguengo, Lívia Mateus, Ribeiro, Beatriz Elias, Ribeiro, Daniel Araki, Rizzato, Julia Soto, Rodríguez-Cabezas, María Elena, Rodríguez-Nogales, Alba, Rodríguez-Sojo, Maria Jesús, Ruiz-Malagón, Antonio Jesús, Salaga, Maciej, Salles, Débora, Silva, Julian Furtado, de Sousa Santos, Carina, de Souza, Heitor Siffert Pereira, Steigleder, Karine Mariane, Świerczyński, Mikołaj, Tarasiuk, Aleksandra, and Vezza, Teresa

Published
2023
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29. ER stress activation in the intestinal mucosa but not in mesenteric adipose tissue is associated with inflammation in Crohn’s disease patients

Author

Coope, Andressa, primary, Pascoal, Lívia Bitencourt, additional, Botezelli, José Diego, additional, da Silva, Francesca Aparecida Ramos, additional, Ayrizono, Maria de Lourdes Setsuko, additional, Rodrigues, Bruno Lima, additional, Milanski, Marciane, additional, Carvalho, Rita Barbosa, additional, Fagundes, João José, additional, Velloso, Lício Augusto, additional, and Leal, Raquel Franco, additional

Published
2019
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46. Transcriptional and molecular pathways activated in mesenteric adipose tissue and intestinal mucosa of Crohn's disease patients

Author

Coope, Andressa, Biazzo, Lívia Aparecida Davila Bitencourt Pascoal, Silva, Francesca Aparecida Ramos da, 1982, Botezelli, José Diego, Ayrizono, Maria de Lourdes Setsuko, 1962, Milanski, Marciane, 1972, Camargo, Michel Gardere, 1979, Portovedo, Mariana, 1987, Fagundes, João Jose, 1943, Leal, Raquel Franco, 1977, and UNIVERSIDADE ESTADUAL DE CAMPINAS

Subjects
Crohn's disease, Doença de Crohn, Artigo de pesquisa
Abstract

Crohn’s disease (CD) is a chronic inflammatory disorder, characterized by cytokine imbalance and transcription signaling pathways activation. In addition, the increase of mesenteric adipose tissue (MAT) near the affected intestinal area is a hallmark of CD. Therefore, we evaluated the transcription signaling pathways and cytokines expression in intestinal mucosa and MAT of active CD patients. Ten patients with ileocecal CD and eight with noninflammatory diseases were studied. The biopsies of intestinal mucosa and MAT were snap-frozen and protein expression was determined by immunoblotting. RNA levels were measured by qPCR. The pIkB/IkB ratio and TNFa level were significantly higher in intestinal mucosa of CD when compared to controls. However, STAT1 expression was similar between intestinal mucosa of CD and controls. Considering the MAT, the pIkB/IkB ratio was significantly lower and the anti-inflammatory cytokine IL10 was significantly higher in CD when compared to controls. Finally, the protein content of pSTAT1 was higher in MAT of CD compared to controls. These findings reinforce the predominance of the proinflammatory NF-kB pathway in CD intestinal mucosa. For the first time, we showed the activation of STAT1 pathway in MAT of CD patients, which may help to understand the physiopathology of this immune mediated disease FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP Aberto

Published
2017

47. Ileal pouch of ulcerative colitis and familial adenomatous polyposis patients exhibit modulation of autophagy markers

Author

Paiva, Nielce Maria, primary, Pascoal, Lívia Bitencourt, additional, Negreiros, Leandro Minatel Vidal, additional, Portovedo, Mariana, additional, Coope, Andressa, additional, Ayrizono, Maria de Lourdes Setsuko, additional, Coy, Claudio Saddy Rodrigues, additional, Milanski, Marciane, additional, and Leal, Raquel Franco, additional

Published
2018
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48. Comparison of time until elective intestinal resection regarding previous anti-tumor necrosis factor exposure: a Brazilian study on patients with Crohn's disease

Author

Kotze, Paulo Gustavo, primary, Magro, Daniela Oliveira, additional, Saab, Barbara, additional, Saab, Mansur Paulo, additional, Pinheiro, Lilian Vital, additional, Olandoski, Marcia, additional, Ayrizono, Maria de Lourdes Setsuko, additional, Martinez, Carlos Augusto Real, additional, and Coy, Claudio Saddy Rodrigues, additional

Published
2018
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