Search

The synthesis of small heterocycles under neat mechanochemical conditions is of great interest in the field of drug design because most of the commercially available drugs contain at least one heterocyclic unit. The sodium borohydride (NaBH4) promoted reductive cyclization to fused dihydrofuran under grinding technique is one of the compendium additions for the clean future. The development of chemoselective reduction under silica‐gel supported conditions represents significant progress in organic synthesis, offering a versatile and efficient method for selective reduction of specific functional groups within complex molecules. Synthesis of isoindole derivatives from the chemoselective reduce product via a sustainable short synthetic pathway is another significant process of our newly developed protocol. Finally, antileishmanial investigations of our synthesized compounds establish a soft bridge between biology and chemistry. [ABSTRACT FROM AUTHOR]

Heterocyclic molecules exhibit significant importance as they possess pharmacological, biological, and industrial applications. Although several excellent synthetic routes have been established for heterocyclic molecules, sustainable synthetic procedures such as microwave, ultrasound, grinding, photochemical, and thermodynamic route maps are needed to be explored further. Furthermore, these techniques become more eco-compatible when they produce value-added products in the absence of solvent. The advantages of these methodologies are to generate a library of small molecules, which will eventually combine to form complex bioactive molecules. In this review, we have emphasized recent studies (2010 to 2022) on the solvent-free conditions of various heterocycles (N, O, S), which have been synthesized via oxidation, reduction, condensation, and conjugated reactions. In this literature survey, glimpses of methodologies with their advantages, mechanistic considerations, and limitations are highlighted. These sustainable, and economically feasible routes will pave the way for a revolutionary corridor in the near future. [ABSTRACT FROM AUTHOR]

Correction for 'Recent developments in the solvent-free synthesis of heterocycles' by Nilabrata Dey et al., New J. Chem., 2023, https://doi.org/10.1039/d3nj01991h. [ABSTRACT FROM AUTHOR]

Herein, we have presented a weak acid-promoted tandem aza-Michael-aldol strategy for the synthesis of diversely fused pyrrolo[1,2- a ]quinoline (tricyclic to pentacyclic scaffolds) by the construction of both pyrrole and quinoline ring in one pot. The described protocol fabricated two C-N bonds and one C-C bond in the pyrrole-quinoline rings which have been sequentially formed under transition-metal-free conditions by the extrusion of eco-friendly water molecules. A ketorolac drug analogue has been synthesized following the current protocol, and one of the synthesized tricyclic pyrrolo[1,2- a ]quinoline fluorophores has been used to detect highly toxic picric acid via the fluorescence quenching effect.