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25 results on '"Azadani, Peyman N."'

1. Upper reference limits of transient ischemic dilation ratio for different protocols on new-generation cadmium zinc telluride cameras: A report from REFINE SPECT registry

Author

Hu, Lien-Hsin, Sharir, Tali, Miller, Robert J.H., Einstein, Andrew J., Fish, Mathews B., Ruddy, Terrence D., Dorbala, Sharmila, Di Carli, Marcelo, Kaufmann, Philipp A., Sinusas, Albert J., Miller, Edward J., Bateman, Timothy M., Betancur, Julian, Germano, Guido, Liang, Joanna X., Commandeur, Frederic, Azadani, Peyman N., Gransar, Heidi, Otaki, Yuka, Tamarappoo, Balaji K., Dey, Damini, Berman, Daniel S., and Slomka, Piotr J.

Published
2020
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2. Rationale and design of the REgistry of Fast Myocardial Perfusion Imaging with NExt generation SPECT (REFINE SPECT)

Author

Slomka, Piotr J., Betancur, Julian, Liang, Joanna X., Otaki, Yuka, Hu, Lien-Hsin, Sharir, Tali, Dorbala, Sharmila, Di Carli, Marcelo, Fish, Mathews B., Ruddy, Terrence D., Bateman, Timothy M., Einstein, Andrew J., Kaufmann, Philipp A., Miller, Edward J., Sinusas, Albert J., Azadani, Peyman N., Gransar, Heidi, Tamarappoo, Balaji K., Dey, Damini, Berman, Daniel S., and Germano, Guido

Published
2020
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3. Asymptomatic Left Bundle Branch Block Predicts New-Onset Congestive Heart Failure and Death From Cardiovascular Diseases.

Author

Azadani, Peyman N, Soleimanirahbar, Ata, Marcus, Gregory M, Haight, Thaddeus J, Hollenberg, Milton, Olgin, Jeffrey E, and Lee, Byron K

Subjects
Bundle-branch block, Heart failure, Mortality, Risk factors, Prevention, Cardiovascular, Heart Disease, Clinical Research
Abstract

BackgroundLeft bundle branch block (LBBB) has been proposed as a risk factor for cardiovascular morbidity and mortality. We sought to characterize the strength of these associations in a population without preexisting clinical heart disease.MethodsThe association between LBBB and new-onset congestive heart failure (CHF) or death from cardiovascular diseases was examined in 1,688 participants enrolled in the SPPARCS study who were free of known CHF or previous myocardial infarction. SPPARCS is a community-based cohort study in residents of Sonoma, California that are > 55 years. Medical history and 12-lead ECGs were obtained every 2 years for up to 6 years of follow-up. LBBB at enrollment or year 2 was considered "baseline" and assessed as a predictor of CHF and cardiovascular death ascertained at years 4 and 6.ResultsThe prevalence of LBBB at baseline was 2.5% (n = 42). During 6 years of follow-up, 70 (4.8%) people developed new CHF. Incidence of CHF was higher in patients with LBBB than in participants without LBBB. This association persisted after controlling for potential confounders (odds ratio (OR): 2.85; 95% confidence interval (CI): 1.01 - 8.02; P = 0.047). A higher mortality from cardiovascular diseases was also found in participants with LBBB after adjusting for potential confounders (OR: 2.35, 95%CI: 1.02 - 5.41; P = 0.044).ConclusionsLBBB in the absence of a clinically detectable heart disease is associated with new-onset CHF and death from cardiovascular diseases. Further study is warranted to determine if additional diagnostic testing or earlier treatment in patients with asymptomatic LBBB can decrease cardiovascular morbidity or mortality.

Published
2012

7. Impact of Early Revascularization on Major Adverse Cardiovascular Events in Relation to Automatically Quantified Ischemia

Author

Azadani, Peyman N, Miller, Robert J H, Sharir, Tali, Diniz, Marcio A, Hu, Lien-Hsin, Otaki, Yuka, Gransar, Heidi, Liang, Joanna X, Eisenberg, Evann, Einstein, Andrew J, Fish, Mathews B, Ruddy, Terrence D, Kaufmann, Philipp A, Sinusas, Albert J, Miller, Edward J, Bateman, Timothy M, Dorbala, Sharmila, Di Carli, Marcelo, Tamarappoo, Balaji K, Dey, Damini, Berman, Daniel S, Slomka, Piotr J, and University of Zurich

Subjects
610 Medicine & health, 10181 Clinic for Nuclear Medicine
Published
2021

8. Impact of Early Revascularization on Major Adverse Cardiovascular Events in Relation to Automatically Quantified Ischemia

Author

Azadani, Peyman N., primary, Miller, Robert J.H., additional, Sharir, Tali, additional, Diniz, Marcio A., additional, Hu, Lien-Hsin, additional, Otaki, Yuka, additional, Gransar, Heidi, additional, Liang, Joanna X., additional, Eisenberg, Evann, additional, Einstein, Andrew J., additional, Fish, Mathews B., additional, Ruddy, Terrence D., additional, Kaufmann, Philipp A., additional, Sinusas, Albert J., additional, Miller, Edward J., additional, Bateman, Timothy M., additional, Dorbala, Sharmila, additional, Di Carli, Marcelo, additional, Tamarappoo, Balaji K., additional, Dey, Damini, additional, Berman, Daniel S., additional, and Slomka, Piotr J., additional

Published
2021
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10. 5-Year Prognostic Value of Quantitative Versus Visual MPI in Subtle Perfusion Defects: Results From REFINE SPECT

Author

Otaki, Yuka, Betancur, Julian, Sharir, Tali, Hu, Lien-Hsin, Gransar, Heidi, Liang, Joanna X, Azadani, Peyman N, Einstein, Andrew J, Fish, Mathews B, Ruddy, Terrence D, Kaufmann, Philipp A, Sinusas, Albert J, Miller, Edward J, Bateman, Timothy M, Dorbala, Sharmila, Di Carli, Marcelo, Tamarappoo, Balaji K, Germano, Guido, Dey, Damini, Berman, Daniel S, Slomka, Piotr J, University of Zurich, and Slomka, Piotr J

Subjects
2741 Radiology, Nuclear Medicine and Imaging, 610 Medicine & health, 10181 Clinic for Nuclear Medicine, 2705 Cardiology and Cardiovascular Medicine
Published
2020

13. 5-Year Prognostic Value of Quantitative Versus Visual MPI in Subtle Perfusion Defects

Author

Otaki, Yuka, primary, Betancur, Julian, additional, Sharir, Tali, additional, Hu, Lien-Hsin, additional, Gransar, Heidi, additional, Liang, Joanna X., additional, Azadani, Peyman N., additional, Einstein, Andrew J., additional, Fish, Mathews B., additional, Ruddy, Terrence D., additional, Kaufmann, Philipp A., additional, Sinusas, Albert J., additional, Miller, Edward J., additional, Bateman, Timothy M., additional, Dorbala, Sharmila, additional, Di Carli, Marcelo, additional, Tamarappoo, Balaji K., additional, Germano, Guido, additional, Dey, Damini, additional, Berman, Daniel S., additional, and Slomka, Piotr J., additional

Published
2020
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14. 5-Year Prognostic Value of Quantitative Versus Visual MPI in Subtle Perfusion Defects: Results From REFINE SPECT

Author

Otaki, Yuka, Betancur, Julian, Sharir, Tali, Hu, Lien-Hsin, Gransar, Heidi, Liang, Joanna X., Azadani, Peyman N., Einstein, Andrew J., Fish, Mathews B., Ruddy, Terrence D., Kaufmann, Philipp A., Sinusas, Albert J., Miller, Edward J., Bateman, Timothy M., Dorbala, Sharmila, Carli, Marcelo Di, Tamarappoo, Balaji K., Germano, Guido, Dey, Damini, Berman, Daniel S., and Slomka, Piotr J.

Subjects
Male, Tomography, Emission-Computed, Single-Photon, Time Factors, Heart Diseases, Cardiology, Myocardial Perfusion Imaging, Middle Aged, Prognosis, Risk Assessment, Article, Predictive Value of Tests, Risk Factors, Coronary Circulation, Humans, Female, cardiovascular diseases, Registries, Aged
Abstract

This study compared the ability of automated myocardial perfusion imaging analysis to predict major adverse cardiac events (MACE) to that of visual analysis.Quantitative analysis has not been compared with clinical visual analysis in prognostic studies.A total of 19,495 patients from the multicenter REFINE SPECT (REgistry of Fast Myocardial Perfusion Imaging with NExt generation SPECT) study (64 ± 12 years of age, 56% males) undergoing stress Tc-99m-labeled single-photon emission computed tomography (SPECT) myocardial perfusion imaging were followed for 4.5 ± 1.7 years for MACE. Perfusion abnormalities were assessed visually and categorized as normal, probably normal, equivocal, or abnormal. Stress total perfusion deficit (TPD), quantified automatically, was categorized as TPD = 0%, TPD0% to 1%, ≤1% to 3%, ≤3% to 5%, ≤5% to ≤10%, or TPD10%. MACE consisted of death, nonfatal myocardial infarction, unstable angina, or late revascularization (90 days). Kaplan-Meier and Cox proportional hazards analyses were performed to test the performance of visual and quantitative assessments in predicting MACE.During follow-up examinations, 2,760 (14.2%) MACE occurred. MACE rates increased with worsening of visual assessments, that is, the rate for normal MACE was 2.0%, 3.2% for probably normal, 4.2% for equivocal, and 7.4% for abnormal (all p 0.001). MACE rates increased with increasing stress TPD from 1.3% for the TPD category of 0% to 7.8% for the TPD category of10% (p 0.0001). The adjusted hazard ratio (HR) for MACE increased even in equivocal assessment (HR: 1.56; 95% confidence interval [CI]: 1.37 to 1.78) and in the TPD category of ≤3% to 5% (HR: 1.74; 95% CI: 1.41 to 2.14; all p 0.001). The rate of MACE in patients visually assessed as normal still increased from 1.3% (TPD = 0%) to 3.4% (TPD ≥5%) (p 0.0001).Quantitative analysis allows precise granular risk stratification in comparison to visual reading, even for cases with normal clinical reading.

Published
2018

15. Upper reference limits of transient ischemic dilation ratio for different protocols on new-generation cadmium zinc telluride cameras: A report from REFINE SPECT registry

Author

Hu, Lien-Hsin, primary, Sharir, Tali, additional, Miller, Robert J. H., additional, Einstein, Andrew J., additional, Fish, Mathews B., additional, Ruddy, Terrence D., additional, Dorbala, Sharmila, additional, Di Carli, Marcelo, additional, Kaufmann, Philipp A., additional, Sinusas, Albert J., additional, Miller, Edward J., additional, Bateman, Timothy M., additional, Betancur, Julian, additional, Germano, Guido, additional, Liang, Joanna X., additional, Commandeur, Frederic, additional, Azadani, Peyman N., additional, Gransar, Heidi, additional, Otaki, Yuka, additional, Tamarappoo, Balaji K., additional, Dey, Damini, additional, Berman, Daniel S., additional, and Slomka, Piotr J., additional

Published
2019
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16. Rationale and design of the REgistry of Fast Myocardial Perfusion Imaging with NExt generation SPECT (REFINE SPECT)

Author

Slomka, Piotr J., primary, Betancur, Julian, additional, Liang, Joanna X., additional, Otaki, Yuka, additional, Hu, Lien-Hsin, additional, Sharir, Tali, additional, Dorbala, Sharmila, additional, Di Carli, Marcelo, additional, Fish, Mathews B., additional, Ruddy, Terrence D., additional, Bateman, Timothy M., additional, Einstein, Andrew J., additional, Kaufmann, Philipp A., additional, Miller, Edward J., additional, Sinusas, Albert J., additional, Azadani, Peyman N., additional, Gransar, Heidi, additional, Tamarappoo, Balaji K., additional, Dey, Damini, additional, Berman, Daniel S., additional, and Germano, Guido, additional

Published
2018
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19. Left Atrial Fibrosis and Risk of Cerebrovascular and Cardiovascular Events in Patients With Atrial Fibrillation

Author

King, Jordan B., primary, Azadani, Peyman N., additional, Suksaranjit, Promporn, additional, Bress, Adam P., additional, Witt, Daniel M., additional, Han, Frederick T., additional, Chelu, Mihail G., additional, Silver, Michelle A., additional, Biskupiak, Joseph, additional, Wilson, Brent D., additional, Morris, Alan K., additional, Kholmovski, Eugene G., additional, and Marrouche, Nassir, additional

Published
2017
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25. Effect of reduced cardiac output on blood stasis on transcatheter aortic valve leaflets: implications for valve thrombosis.

Author

Vahidkhah K, Abbasi M, Barakat M, Azadani PN, Tandar A, Dvir D, and Azadani AN

Subjects
Aged, Aortic Valve Stenosis diagnosis, Computer Simulation, Female, Heart Valve Prosthesis adverse effects, Humans, Stress, Mechanical, Thrombosis diagnosis, Thrombosis therapy, Aortic Valve surgery, Aortic Valve Stenosis surgery, Thrombosis pathology, Transcatheter Aortic Valve Replacement methods
Abstract

Aims: There is an increasing awareness of leaflet thrombosis following transcatheter aortic valve implantation (TAVI) and valve-in-valve (ViV) procedures. Nevertheless, the predisposing factors affecting transcatheter aortic valve (TAV) thrombosis have remained unclear. This study aimed to quantify the effects of reduced cardiac output (CO) on blood stasis on the TAV leaflets as a permissive factor for valve thrombosis., Methods and Results: An idealised computational model representing a TAV was developed in a patient-specific geometry. Three-dimensional flow fields were obtained via a fluid-solid interaction modelling approach at different COs: 5.0, 3.5, 2.0 L/min. Blood residence time (BRT) was subsequently calculated on the leaflets. An association between reduced CO and increased blood stasis on the TAV leaflets was observed. At the end of diastole, larger areas of high BRT (>1.2 s) were observed at the leaflet's fixed edge at low COs. Such areas were calculated to be 2, 8, and 11% of the total surface area of leaflets at CO=5.0, 3.5, and 2.0 L/min, respectively, indicating a ~sixfold increase of BRT on the leaflets from the highest to the lowest CO., Conclusions: This study indicates an association between reduced CO and increased blood stasis on the TAV leaflets which can be regarded as a precursor of valve thrombosis.

Published
2017
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