130 results on '"Azukizawa M"'
Search Results
2. Distinct biomarkers for different bones in osteoporosis with rheumatoid arthritis
- Author
-
Tomizawa, T., Ito, H., Murata, K., Hashimoto, M., Tanaka, M., Murakami, K., Nishitani, K., Azukizawa, M., Okahata, A., Doi, K., Saito, M., Furu, M., Hamaguchi, M., Mimori, T., and Matsuda, S.
- Published
- 2019
- Full Text
- View/download PDF
3. Periarticular osteoporosis of the forearm correlated with joint destruction and functional impairment in patients with rheumatoid arthritis
- Author
-
Iwata, T., Ito, H., Furu, M., Hashimoto, M., Fujii, T., Ishikawa, M., Yamakawa, N., Terao, C., Azukizawa, M., Hamamoto, Y., Mimori, T., Akiyama, H., and Matsuda, S.
- Published
- 2016
- Full Text
- View/download PDF
4. The Role of Musculoskeletal Ultrasound in the Rheumatoid Arthritis Continuum
- Author
-
Di Matteo, A, Mankia, K, Azukizawa, M, and Wakefield, RJ
- Abstract
Purpose of Review: Rheumatoid arthritis (RA) is no longer considered a fixed phenotype but rather a disease continuum. This review outlines the current and potential value of applying ultrasound (US) along this continuum: from the prediction of progression to RA in at-risk individuals, to confirmation of the early diagnosis of RA, as well as the consideration of differential diagnoses, and the use in disease monitoring and defining remission. Recent Findings: In individuals at-risk of RA (i.e., positive autoantibodies with symptoms but without synovitis), US has shown a promising predictive value for the development of clinical arthritis, providing the opportunity to improve risk stratification (and disease prevention) of these individuals. The detection of inflammation on US in patients with early undifferentiated arthritis, in which a definite diagnosis cannot be reached, could predict evolution to persistent arthritis, mostly RA. This, in addition to the US potential ability to identify disease specific patterns for different rheumatic conditions, might facilitate early diagnosis and, therefore, improve the management of patients with RA, or other types of inflammatory arthritides. US has also demonstrated the capability to predict radiographic progression, and relapse risk after treatment discontinuation, in RA patients in remission according to the clinical instruments, raising implications in the management, including therapy discontinuation, of these patients. Summary: US has an undeniable value in the management of patients at different stages along the RA continuum. Further research is needed to identify which groups of patients benefit the most from US imaging.
- Published
- 2020
5. Free radical polymerization of cyclohexyl acrylate involving interconversion between propagating and mid-chain radicals
- Author
-
Yamada, B, Azukizawa, M, Yamazoe, H, Hill, D.J.T, and Pomery, P.J
- Published
- 2000
- Full Text
- View/download PDF
6. AB1171 Ultrasound assessment of the knee in elderly japanese population
- Author
-
Okahata, A., primary, Ito, H., additional, Furu, M., additional, Kuriyama, S., additional, Nakamura, S., additional, Ishikawa, M., additional, Morita, Y., additional, Azukizawa, M., additional, Hamamoto, Y., additional, Tanaka, Y., additional, Tabara, Y., additional, Matsuda, F., additional, and Matsuda, S., additional
- Published
- 2018
- Full Text
- View/download PDF
7. AB1335 Serum mmp-3 is closely related to knee joint symptoms in rheumatoid arthritis patients: a cross-sectional study from kurama cohort
- Author
-
Azukizawa, M., primary, Ito, H., additional, Nishitani, K., additional, Murata, K., additional, Okahata, A., additional, Tomizawa, T., additional, Hashimoto, M., additional, Tanaka, M., additional, Mimori, T., additional, and Matsuda, S., additional
- Published
- 2018
- Full Text
- View/download PDF
8. Comparative study of resection and joint-preserving arthroplasty for rheumatoid foot deformity
- Author
-
Azukizawa, M., primary, Ito, H., additional, Furu, M., additional, Nishitani, K., additional, Morita, Y., additional, Okahata, A., additional, Tomizawa, T., additional, and Matsuda, S., additional
- Published
- 2017
- Full Text
- View/download PDF
9. Subsidence of TAA associated with deterioration of ankle scale only in non-inflammatory arthritis
- Author
-
Ito, H., primary, Takahiro, I., additional, Furu, M., additional, Ishikawa, M., additional, Azukizawa, M., additional, and Matsuda, S., additional
- Published
- 2017
- Full Text
- View/download PDF
10. SAT0621 Effect of An Exercise Therapy on Systemic Biomarkers for Cartilage Metabolism
- Author
-
Azukizawa, M., primary, Ito, H., additional, Yasuda, T., additional, Furu, M., additional, Hamamoto, Y., additional, Fujii, T., additional, Morita, Y., additional, Okahata, A., additional, Masamoto, K., additional, and Matsuda, S., additional
- Published
- 2016
- Full Text
- View/download PDF
11. Periarticular osteoporosis of the forearm correlated with joint destruction and functional impairment in patients with rheumatoid arthritis
- Author
-
Iwata, T., primary, Ito, H., additional, Furu, M., additional, Hashimoto, M., additional, Fujii, T., additional, Ishikawa, M., additional, Yamakawa, N., additional, Terao, C., additional, Azukizawa, M., additional, Hamamoto, Y., additional, Mimori, T., additional, Akiyama, H., additional, and Matsuda, S., additional
- Published
- 2015
- Full Text
- View/download PDF
12. SAT0301 Periarticular Osteoporosis of the Forearm Correlated with Joint Destruction and Functional Impairment in Patients With Rheumatoid Arthritis
- Author
-
Iwata, T., primary, Ito, H., additional, Furu, M., additional, Hashimoto, M., additional, Fujii, T., additional, Ishikawa, M., additional, Yamakawa, N., additional, Terao, C., additional, Azukizawa, M., additional, Hamamoto, Y., additional, Mimori, T., additional, Akiyama, H., additional, and Matsuda, S., additional
- Published
- 2015
- Full Text
- View/download PDF
13. AB0268 Metatarsophalangeal Joint Dislocation has Clinical Impact on Global Functional Impairment in Patients with Rheumatoid Arthritis – a Cross-Sectional Study from Kurama Cohort-
- Author
-
Ito, H., primary, Hamamoto, Y., additional, Furu, M., additional, Hashimoto, M., additional, Fujii, T., additional, Ishikawa, M., additional, Azukizawa, M., additional, Terao, C., additional, Mimori, T., additional, and Matsuda, S., additional
- Published
- 2015
- Full Text
- View/download PDF
14. Systemic effects of surgical intervention on disease activity, daily function, and medication in patients with rheumatoid arthritis.
- Author
-
Iwata, T, Ito, H, Furu, M, Hashimoto, M, Fujii, T, Ishikawa, M, Azukizawa, M, Hamamoto, Y, Mimori, T, Akiyama, H, and Matsuda, S
- Subjects
RHEUMATOID arthritis ,ORTHOPEDIC surgery ,ARTHROPLASTY ,ANTIRHEUMATIC agents ,POSTOPERATIVE period ,PATIENTS ,FOOT surgery ,THERAPEUTIC use of glucocorticoids ,HAND surgery ,JOINT surgery ,SPINAL surgery ,SYNOVIAL membranes surgery ,PREDNISOLONE ,ARTHRODESIS ,ARTIFICIAL joints ,BLOOD sedimentation ,LONGITUDINAL method ,QUESTIONNAIRES ,ACTIVITIES of daily living ,TREATMENT effectiveness ,SEVERITY of illness index ,THERAPEUTICS - Abstract
Objectives: Although tight control of rheumatoid arthritis (RA) has been achieved through the development of effective medication, surgical intervention is still required for a certain subpopulation of patients. To examine the systemic effects of orthopaedic surgery, we evaluated improvements in disease activity, daily function, and medication after surgery.Method: A prospective cohort study was conducted in 196 cases of elective orthopaedic surgery in 150 patients with RA from January 2011 to March 2014 in our institution. The 28-joint count Disease Activity Score based on erythrocyte sedimentation rate (DAS28-ESR) and modified Health Assessment Questionnaire (mHAQ) scores just before surgery and at 6 and 12 months after surgery were examined prospectively. Concomitant medications were also investigated.Results: Significant improvement was seen in the DAS28-ESR and mHAQ scores for replacement surgery in both the upper and lower extremities, and for arthroplasty/arthrodesis in the upper extremities at the 12-month follow-up. Partial mHAQ scores for the lower extremities were significantly reduced in lower replacement surgery, and partial mHAQ scores for the upper extremities were significantly reduced in upper arthroplasty/arthrodesis surgery. Although the use of conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) did not decrease after surgery, the dose of prednisolone (PSL) decreased significantly at 12 months after surgery, especially in the well-controlled group and in surgical procedures in the lower extremities.Conclusions: Elective orthopaedic surgery improves both systemic disease activity and general functional impairment. Orthopaedic surgery is effective in reducing the amount of medication required postoperatively. [ABSTRACT FROM AUTHOR]- Published
- 2016
- Full Text
- View/download PDF
15. Periarticular osteoporosis of the forearm correlated with joint destruction and functional impairment in patients with rheumatoid arthritis.
- Author
-
Furu, M., Ishikawa, M., Iwata, T., Ito, H., Azukizawa, M., Hamamoto, Y., Matsuda, S., Hashimoto, M., Fujii, T., Yamakawa, N., Mimori, T., Terao, C., and Akiyama, H.
- Subjects
ARM ,FOREARM ,INFORMATION storage & retrieval systems ,MEDICAL databases ,JOINT diseases ,LONGITUDINAL method ,OSTEOPOROSIS ,QUESTIONNAIRES ,REGRESSION analysis ,RHEUMATOID arthritis ,BONE density ,DISEASE remission ,CROSS-sectional method ,ELECTRONIC health records - Abstract
Summary: The relationship between periarticular osteoporosis in the distal forearm and joint destruction or functional impairment in patients with rheumatoid arthritis (RA) is not sufficiently elucidated. From a single institutional cohort study, we found a strong correlation between periarticular forearm bone mineral density (BMD) and joint destruction or functional impairment. Introduction: This study was conducted to investigate (1) the difference between various periarticular regions of interest (ROIs) of BMD of the forearm, (2) the correlation between periarticular forearm BMD and joint destruction and physical function, (3) the independent variables for predicting BMD of the forearm, and (4) the forearm BMD of different ROIs in the early stage of RA. Methods: We conducted a cross-sectional study in an RA cohort. Measurements included BMD of the distal forearm, joint destruction of the hands assessed by modified total Sharp score (mTSS), functional impairment assessed by a health assessment questionnaire (HAQ), and other clinical data. Variables affecting the forearm BMD values were analyzed by correlation and stepwise regression analyses. Results: Of the 405 patients enrolled in the present study, 370 (average age; 62.9 years) were identified as having definite RA with a complete set of data. BMD in the distal end of the forearm (BMDud) was significantly reduced compared with that in the distal third of the forearm (BMD1/3). In a stepwise regression analysis, the mTSS in BMD1/3 was an independent predicting variable, while age and partial HAQ scores associated with the upper extremity were common independent variables in BMDud and BMD1/3. BMDud was significantly less than BMD1/3, even in patients with a short duration of the disease. BMD1/3 was significantly less in non-remission group compared with that in remission group in patients with a short duration of the disease. Conclusion: Periarticular BMD in the distal forearm is closely correlated with joint destruction and functional impairment in RA. Periarticular BMD in the distal forearm may be already reduced at the clinical manifestation of the disease. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
16. Bioassay and Immunoassay Measurements of Serum Thyrotropin in Primary Hypothyroidism Before and After the Administration of Thyrotropin Releasing Hormone.
- Author
-
Miyai, K., Azukizawa, M., and Kumahara, Y.
- Published
- 1974
- Full Text
- View/download PDF
17. Studies on hypothermia and thyroid function in the obese (ob/ob) mouse.
- Author
-
OHTAKE, M., BRAY, G. A., and AZUKIZAWA, M.
- Published
- 1977
- Full Text
- View/download PDF
18. Penultimate Unit Effects in Free Radical Copolymerization Studied Using the Individual Propagating Radical Concentrations from Electron Spin Resonance Spectroscopy
- Author
-
Zetterlund, P. B., Tagashira, S., Izumi, K., Nagano, Y., Azukizawa, M., Yamazoe, H., Kumagai, M., and Yamada, B.
- Abstract
The scope of the ESR technique has been expanded to enable direct measurement of the individual propagating radical concentrations in a binary free radical copolymerization. The ESR spectra observed during the copolymerization of the deuterated monomers styrene-d
5 and cyclohexyl methacrylate-d5 in benzene at 60 °C could be accounted for as the superimposed spectra of the homopolymerization systems, the outermost regions of the spectrum unambiguously assigned to macroradicals with styrene-d5 as the terminal unit. The penultimate model with an implicit penultimate unit effect (PUE) was fitted to the ratio of the propagating radical concentrations (A12 ) and the copolymer composition, resulting in the radical reactivity ratios s1 = k211 /k111 = 0.45 and s2 = k122 /k222 = 0.50. Simultaneous fitting of A12 and the copolymerization propagation rate coefficient (&kmacr;p ) resulted in lower s values (s1 = 0.08, s2 = 0.10). Optimization procedures employing the penultimate model with an explicit PUE and the entire data set (copolymer composition, A12 and &kmacr;p ) indicated that the total sum of residuals could be further decreased compared with when the restriction of an implicit PUE was imposed on the model, but this was at the expense of the quality of the prediction of copolymer composition, which then became unacceptable.- Published
- 2002
- Full Text
- View/download PDF
19. Reversible Cobalt−Carbon Bond Formation in Catalytic Chain Transfer Polymerization
- Author
-
Heuts, J. P. A., Forster, D. J., Davis, T. P., Yamada, B., Yamazoe, H., and Azukizawa, M.
- Abstract
The reversible bond formation between cobalt(II) catalytic chain transfer agents and propagating radicals was studied using electron paramagnetic resonance and conventional kinetic measurements. It was found that this reversible cobalt−carbon bond formation has no significant effect on the catalytic chain transfer polymerization of methyl methacrylate but does affect the polymerization behavior of styrene. In both systems significant induction periods are observed which seem to disappear in the methyl methacrylate system but persist in the styrene system upon decreasing the initial concentration of the cobalt(II) complex. The overall rates of polymerizations are found to be readily described by classical free-radical polymerization kinetics, including a chain-length-dependent average termination rate coefficient. Furthermore, in contrast to the situation observed in methyl methacrylate polymerization where constant molecular weights are produced over the entire conversion range, it was found that the molecular weight in styrene increases with conversion until a constant molecular weight is obtained which is given by the Mayo equation. The kinetic behavior and the molecular weight evolution could simply be modeled by a reaction scheme providing a constant radical concentration and the presence of a chain transfer agent.
- Published
- 1999
20. STUDIES ON THE INTERACTION OF LONG-ACTING THYROID STIMULATOR (LATS) WITH SOLUBLE THYROID FRACTIONS
- Author
-
Amino, N., Miyai, K., Azukizawa, M., and Kumahara, Y.
- Abstract
The specificity, stability and reversibility of the in vitrointeraction of LATS with soluble human thyroid fractions was studied. With regard to tissue specificity, the cell sap obtained from human liver, spleen, kidney, and muscle did not inhibit the LATS activity while the same amount of thyroid cell sap significantly inhibited it. When the LATS inhibitory activity in thyroid subcellular fractions was compared, the microsomal fraction was more active than cell sap or solubilized microsomes in terms of milligram of protein, but the cell sap had considerable activity as based on the original thyroid weight. Lyophilization of cell sap did not reduce the LATS inhibitory activity, but treatment with 2 m NaSCN and 6 murea apparently destroyed this capacity. Acid treatment of cell sap at pH 2.5 and at 3.0 completely destroyed its ability to inhibit LATS activity. Inhibition of LATS activity was roughly proportional to the amount of thyroid cell sap. Human TSH, on the other hand, was not inhibited by cell sap which had a significant inhibitory effect on LATS. LATS activity was more effectively inhibited when a mixture of LATS-IgG and thyroid cell sap was incubated for 96 hours than for 12 hours. The inhibition of LATS activity by thyroid cell sap was partially but significantly reversed by acid treatment, as observed in experiment using microsomes. When thyroid cell sap was fractionated by gel filtration on Sepharose 4B, LATS inhibitory activity was distributed in all the fractions including the 27S to 4S proteins. In DEAE-cellulose column chromatography, LATS inhibitory activity tended to be eluted at a higher ionic strength. In each fraction of Sepharose 4B and DEAE-cellulose, LATS inhibitory activity was found to be unrelated to the thyroglobulin content.It is believed that the inhibition of LATS activity by thyroid cell sap is compatible with an antigen-antibody reaction and that the LATS inhibitor may not be a thyroglobulin itself but a more negatively charged heterogeneous substance.
- Published
- 1971
- Full Text
- View/download PDF
21. IN VITRO EFFECTS OF LATS AND TSH ON PHOSPHODIESTERASE ACTIVITY IN HUMAN THYROID HOMOGENATES
- Author
-
Miyai, K., Amino, N., Azukizawa, M., and Kumahara, Y.
- Abstract
The in vitroeffects of long-acting thyroid stimulator (LATS) and thyrotrophin (TSH) on phosphodiesterase activity in human thyroid homogenates were studied. The enzyme activity was estimated by the destruction of 3H-cyclic 3′,5′-adenosine monophosphate. Bovine TSH had no effect on the enzyme activity. Five experiments were carried out using different batches of LATS-IgG and normal IgG which were preincubated with thyroid homogenates or not. There was no significant difference between the enzyme activity with LATS-IgG and that with normal IgG, while the activity was mostly inhibited by theophylline. These data are not consistent with the hypothesis that LATS acts as an antibody to phosphodiesterase.
- Published
- 1971
- Full Text
- View/download PDF
22. Propylthiouracil blocks extrathyroidal conversion of thyroxine to triiodothyronine and augments thyrotropin secretion in man.
- Author
-
Geffner, D L, primary, Azukizawa, M, additional, and Hershman, J M, additional
- Published
- 1975
- Full Text
- View/download PDF
23. Fundamental and Clinical Studies of Hypophysis 1
- Author
-
ICHIKAWA, Y., primary, OYAMA, T., additional, TAKIGUCHI, M., additional, KUDO, T., additional, NAKAGAWA, K., additional, SETAISHI, C., additional, IMURA, H., additional, MIYAI, K., additional, FUKUCHI, M., additional, INOUE, T., additional, AZUKIZAWA, M., additional, KUMAHARA, Y., additional, SAKODA, M., additional, DEMURA, H., additional, SAKUMA, M., additional, OKADA, Y., additional, HIROSHIGE, T., additional, SAWANO, S., additional, and SHIZUME, K., additional
- Published
- 1970
- Full Text
- View/download PDF
24. Pathogenesis of Hyperthyroidism
- Author
-
MIYAI, Kiyoshi, primary, FUKUCHI, M., additional, AMINO, N., additional, and AZUKIZAWA, M., additional
- Published
- 1970
- Full Text
- View/download PDF
25. How do symptoms of each joint contribute to global pain, disease activity and functional disability in rheumatoid arthritis?-A comprehensive association study using a large cohort.
- Author
-
Umemoto A, Ito H, Azukizawa M, Murata K, Tanaka M, Fujii T, Onishi A, Onizawa H, Ishie S, Murakami A, Nishitani K, Murakami K, Yoshitomi H, Hashimoto M, Morinobu A, and Matsuda S
- Subjects
- Humans, Pain, Wrist, Ankle Joint, Arthritis, Rheumatoid, Elbow Joint
- Abstract
Background: Established assessment tools for patients with rheumatoid arthritis (RA), including disease activity scores (DASs), disease activity indexes (DAIs), visual analog scales (VASs), and health assessment questionnaires (HAQs), are widely used. However, comparative associations between joint involvement and disease status assessment tools have rarely been investigated., Methods: We included a dataset of 4016 patients from a large RA cohort from 2012 to 2019. The tenderness and swelling of each joint were counted as a symptom, with 70 and 68 affected joints throughout the body, respectively. The relative contribution of various joints to the disease status assessment tools, VAS scores, and functional disability indexes was analyzed using multiple regression analysis., Results: The wrist showed the most significant contribution overall, especially in DASs and VASs, while the metacarpophalangeal and proximal interphalangeal joints made significant contributions to DASs and DAIs, but not to VASs and HAQs. The shoulder and the elbow significantly contributed to HAQs, but only the shoulder did to the VASs. The knee universally contributed to all of the tools, but the ankle played a minor but important role in most assessment tools, especially in HAQs. Similar but different contribution ratios were found between the sets of DASs, DAIs, VASs, or HAQs., Conclusions: Each joint makes a unique contribution to these assessment tools. The improvement or aggravation of symptoms in each joint affects the assessment tools in different manners., Competing Interests: I have read the journal’s policy and the authors of this manuscript have the following competing interests: AO, HO, TF, KMurat, and MT belong to the department financially supported by two local governments in Japan (Nagahama City, Shiga and Toyooka City, Hyogo) and five pharmaceutical companies (Mitsubishi Tanabe Pharma Co., Chugai Pharmaceutical Co., Ltd., AYUMI Pharmaceutical Co., Asahi Kasei Pharma Co. and UCB Japan Co., Ltd.). KURAMA cohort study is supported by grant from Daiichi Sankyo Co. Ltd. HI has received a research grant and/or speaker fee from Bristol-Myers Squibb. MT has received research grants and/or speaker fees from Abbvie Inc., Asahi Kasei Pharma Co., Astellas Pharma Inc., Chugai Pharmaceutical Co. Ltd., Daiichi Sankyo Co., Ltd., Eisai Co. Ltd., Eli Lilly Japan K.K., Janssen Pharmaceutical K.K., Kyowa Kirin Co. Ltd., Pfizer Inc., Taisho Pharmaceutical Co. Ltd., Mitsubishi Tanabe Pharma Co., Teijin Pharma Ltd.,and UCB Japan Co. Ltd. AO reports grants from Pfizer Inc., Bristol-Myers Squibb., Ayumi, The Health Care Science Institute, and Advantest, and personal fees from Asahi Kasei Pharma Co., Chugai Pharmaceutical Co. Ltd., Eli Lilly Japan K.K, Ono Pharmaceutical Co., Mitsubishi Tanabe Pharma, Eisai Co. Ltd., Abbvie Inc., Takeda Pharmaceutical Company Limited, and Daiichi Sankyo Co. Ltd.. MH receives grants and /or speaker fees from Abbvie Inc., Asahi Kasei Pharma Co., Astellas Pharma Inc., AYUMI Pharmaceutical Co., Bristol-Meyers, Chugai Pharmaceutical Co. Ltd, Daiichi Sankyo Co. Ltd, EA Pharma, Eisai Co. Ltd., Eli Lilly Japan K.K., Nihon Shinyaku, Novartis Pharma, and Mitsubishi Tanabe Pharma Co.. AU, MA, SI, AMu, KN, KMurak, HY, AMo and SM declared no conflicts of interest. This study is conducted as an investigator initiate study. The sponsors were not involved in the study design; in the collection, analysis, interpretation of data; in the writing of this manuscript; or in the decision to submit the article for publication. The authors, their immediate families, and any research foundations with which they are affiliated have not received any financial payments or other benefits from any commercial entity related to the subject of this article., (Copyright: © 2023 Umemoto et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
- Published
- 2023
- Full Text
- View/download PDF
26. Feasibility of patient-oriented ultrasound joint selection: Cross-sectional observational study on rheumatoid arthritis.
- Author
-
Kawahara R, Nakabo S, Shimizu M, Yamamoto H, Sasai T, Nishida Y, Funakoshi S, Gon Y, Taniguchi M, Nakajima T, Hiwa R, Hashimoto M, Tomizawa T, Azukizawa M, Nishitani K, Murata K, Tanaka M, Ito H, Mimori T, and Fujii Y
- Subjects
- Adult, Aged, Feasibility Studies, Female, Humans, Male, Middle Aged, Wrist Joint diagnostic imaging, Arthralgia diagnostic imaging, Arthritis, Rheumatoid diagnostic imaging, Ultrasonography, Doppler methods
- Abstract
Objective: Ultrasonography (US) is a useful tool for evaluating the activity of rheumatoid arthritis (RA) patients. As the systemic evaluation of many joints is time-consuming, a method to evaluate this activity with a smaller number of joints is needed. The aim of this study was to clarify whether the number of joints assessed may be reduced using patient-oriented joint selection. Methods: A total of 492 RA patients were recruited at Kyoto University Hospital. Bilateral metacarpophalangeal (MCP), (proximal) interphalangeal (PIP/IP), and wrist joints were evaluated by US. Gray scale and power Doppler imaging findings were scored by a 0-3 semi-quantitative method. Clinical assessments were performed by physicians who were blind to US results, and a questionnaire on subjective symptoms was collected from each patient. Results: The correlation between the US score of all 22 joints (US22) and patient-oriented painful joints (PtUS) or physician-oriented tender and/or swollen joints were moderate (Spearman's ρ = 0.435) and weak (ρ = 0.383), respectively. These correlations were weaker than that between the total US score of 5 preselected joints (unilateral 2MCP, 3MCP, 2PIP, 3PIP, and the wrist) and US22 (ρ = 0.813). However, when focusing on patients whose painful joints were 5 and more, the correlation between PtUS and US22 was markedly stronger (ρ = 0.757). Conclusion: Patient-oriented joint selection reflected actual joint inflammation to some extent. However, excessive reductions in the number of joints assessed need to be avoided even if patients do not have arthralgia because of the potential for underestimations.
- Published
- 2020
- Full Text
- View/download PDF
27. Soluble Lectin-like Oxidized Low-Density Lipoprotein Receptor 1 Predicts the Changes of Rheumatoid Factor Titers in Rheumatoid Arthritis.
- Author
-
Okahata A, Ito H, Furu M, Ishikawa M, Fujii T, Hashimoto M, Tanaka M, Morita Y, Azukizawa M, Tomizawa T, Doi K, Nishitani K, Murata K, Yoshitomi H, Mimori T, and Matsuda S
- Subjects
- Biomarkers blood, Enzyme-Linked Immunosorbent Assay, Humans, Longitudinal Studies, Arthritis, Rheumatoid diagnosis, Rheumatoid Factor blood, Scavenger Receptors, Class E blood
- Abstract
Objective: The aim of this longitudinal study was to examine the clinical significance of soluble lectin-like oxidized low-density lipoprotein receptor 1 (sLOX-1) in patients with rheumatoid arthritis., Methods: We gathered demographic and clinical data for a large rheumatoid arthritis cohort at 3 time points. Blood samples were collected at each time point; the number of samples was 282 cases in 2012, 431 cases in 2013, and 500 cases in 2014. Plasma sLOX-1 was measured by enzyme-linked immunosorbent assay. Correlations between sLOX-1 and clinical data were analyzed. Predictive factors associated with changes in sLOX-1 and rheumatoid factor (RF) were analyzed by multivariate linear regression., Results: Plasma sLOX-1 level was significantly correlated with RF titer and other clinical parameters. The longitudinal analyses showed that changes in sLOX-1 were significantly correlated with changes in RF titers and with those at baseline. Multivariate linear regression analysis revealed that changes in RF and baseline RF were predictive factors for changes in sLOX-1. Conversely, the changes in RF were significantly correlated with the changes in sLOX-1 in all years. A stepwise regression analysis showed that the change in sLOX-1 was a predictive factor for the change in RF., Conclusions: The change in sLOX-1 has predictive value for assessing the change in RF, indicating the usefulness of sLOX-1 in clinical practice.
- Published
- 2020
- Full Text
- View/download PDF
28. Destructive arthritis with cutaneous polyarteritis nodosa requiring surgical intervention: a case report and review of the literature.
- Author
-
Iwata T, Ito H, Furu M, Ishikawa M, Azukizawa M, Akiyama H, and Matsuda S
- Subjects
- Arthrodesis methods, Arthroscopy methods, Disease Management, Humans, Polyarteritis Nodosa diagnosis, Synovectomy methods, Treatment Outcome, Polyarteritis Nodosa surgery
- Abstract
Arthralgia is a well-known complication of cutaneous polyarteritis nodosa (CPN). However, few cases of destructive arthritis with CPN resulting in chronic pain and disability have been documented. Here we report a case of CPN associated with destructive arthritis of the right foot, accompanied by seronegative arthritis in the right ankle, for which orthopaedic surgery was necessary. X-ray and computed tomography revealed progressive joint destruction in the right talonavicular joint, and magnetic resonance imaging demonstrated severe synovitis of the right talocrural joint. When the talonavicular joint was opened, we observed marked synovitis and a defect in the cartilage that had expanded within the joint. Although mild cartilage degeneration was observed in the talocrural joint, arthroscopic observation revealed no massive defect on the articulated surface. Arthrodesis and arthroscopic synovectomy yielded a good midterm clinical outcome, indicating that surgical intervention was useful for the treatment for destructive arthritis with CPN. Rheumatologists and orthopaedic surgeons should be aware of potential complications such as destructive arthritis when treating patients with CPN.
- Published
- 2020
- Full Text
- View/download PDF
29. The Role of Musculoskeletal Ultrasound in the Rheumatoid Arthritis Continuum.
- Author
-
Di Matteo A, Mankia K, Azukizawa M, and Wakefield RJ
- Subjects
- Autoantibodies, Humans, Inflammation, Synovitis diagnostic imaging, Ultrasonography, Arthritis, Rheumatoid diagnostic imaging, Musculoskeletal System diagnostic imaging
- Abstract
Purpose of Review: Rheumatoid arthritis (RA) is no longer considered a fixed phenotype but rather a disease continuum. This review outlines the current and potential value of applying ultrasound (US) along this continuum: from the prediction of progression to RA in at-risk individuals, to confirmation of the early diagnosis of RA, as well as the consideration of differential diagnoses, and the use in disease monitoring and defining remission., Recent Findings: In individuals at-risk of RA (i.e., positive autoantibodies with symptoms but without synovitis), US has shown a promising predictive value for the development of clinical arthritis, providing the opportunity to improve risk stratification (and disease prevention) of these individuals. The detection of inflammation on US in patients with early undifferentiated arthritis, in which a definite diagnosis cannot be reached, could predict evolution to persistent arthritis, mostly RA. This, in addition to the US potential ability to identify disease specific patterns for different rheumatic conditions, might facilitate early diagnosis and, therefore, improve the management of patients with RA, or other types of inflammatory arthritides. US has also demonstrated the capability to predict radiographic progression, and relapse risk after treatment discontinuation, in RA patients in remission according to the clinical instruments, raising implications in the management, including therapy discontinuation, of these patients. US has an undeniable value in the management of patients at different stages along the RA continuum. Further research is needed to identify which groups of patients benefit the most from US imaging.
- Published
- 2020
- Full Text
- View/download PDF
30. The Effects of Well-Rounded Exercise Program on Systemic Biomarkers Related to Cartilage Metabolism.
- Author
-
Azukizawa M, Ito H, Hamamoto Y, Fujii T, Morita Y, Okahata A, Tomizawa T, Furu M, Nishitani K, Kuriyama S, Nakamura S, Yoshitomi H, Nakatani T, Tsuboyama T, Hamaguchi M, Matsuda S, and Yasuda T
- Subjects
- Aged, Biomarkers metabolism, Cartilage Oligomeric Matrix Protein blood, Collagen Type II metabolism, Exercise physiology, Exercise Test methods, Female, Humans, Knee Joint diagnostic imaging, Middle Aged, Osteoarthritis, Knee diagnostic imaging, Osteoarthritis, Knee metabolism, Osteoarthritis, Knee physiopathology, Radiography, Severity of Illness Index, Cartilage, Articular metabolism, Exercise Therapy methods, Knee Joint metabolism, Osteoarthritis, Knee rehabilitation
- Abstract
Nonsurgical treatment such as exercise is the preferred method for management of knee osteoarthritis (OA). A combination of aerobic, muscle strengthening, and flexibility exercises is recommended for older adults. However, effects of the exercise intervention on cartilage metabolism remain unclear. This study used biomarkers to investigate the effects of well-rounded exercise program on cartilage metabolism in 42 women (mean age: 59 years). Participants started a weekly supervised exercise program and continued for 12 weeks. Before and after the program, we measured physical performance on the Timed Up-and-Go Test, 3-Minute Walk Test, and 30-Second Chair Stand Test. We collected serum and urine samples at the start of the program until 24 weeks and measured the concentrations of 4 biomarkers related to type II collagen metabolism: serum cartilage type II procollagen carboxy propeptide (sPIICP), urine C-terminal telopeptide of collagen type II (uCTX-II), urine cleavage of type II collagen by collagenases (uC2C), and serum cartilage oligomeric matrix protein (sCOMP). Participants were divided into pre-OA and OA groups based on X-ray findings. The pre-OA group showed significant increases and decreases in sPIICP and uCTX-II concentrations with improved physical performance, respectively. sCOMP concentrations significantly increased in both groups. The exercise also improved physical performance with no detrimental effect on type II collagen metabolism in the OA group. Thus, well-rounded exercise may not only improve physical capacity but also have beneficial effects on type II collagen metabolism, especially in people without radiological OA.
- Published
- 2019
- Full Text
- View/download PDF
31. Low back pain precedes the development of new knee pain in the elderly population; a novel predictive score from a longitudinal cohort study.
- Author
-
Ito H, Tominari S, Tabara Y, Nakayama T, Furu M, Kawata T, Azukizawa M, Setoh K, Kawaguchi T, Matsuda F, and Matsuda S
- Subjects
- Aged, Cohort Studies, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Middle Aged, Multivariate Analysis, Pain Measurement standards, Population Surveillance methods, Predictive Value of Tests, Prospective Studies, Arthralgia diagnosis, Arthralgia etiology, Knee Joint pathology, Low Back Pain complications, Low Back Pain diagnosis, Pain Measurement methods
- Abstract
Background: To investigate the association between knee pain and risk factors including low back pain and to develop a score to predict new knee pain in an older population, using population-based longitudinal cohort data., Methods: We collected a questionnaire on self-reported knee pain and demographic data in a systematic manner from community residents aged ≥ 50 years twice, at baseline, and after 5 years. Multivariate logistic regression analyses were performed to investigate the association between knee pain and risk factors and to build a predictive model that would enable calculation of the risk of the development of knee pain within 5 years. The model is presented in the form of score charts., Results: A total of 5932 residents aged ≥ 50 years from the cohort of 9764 that completed the first questionnaire were enrolled in the second survey. After exclusions, paired data for the two time points an average of 5.4 years apart were analyzed for 4638 participants. Multivariate analyses showed older age, female sex, higher BMI, weight increase, lower mental health score, and higher back pain/disability score were independent risk factors for knee pain. The predictive score comprised six factors: age, sex, BMI, weight increase, mental health, and low back pain/disability. The risk of developing knee pain ranged from 11.0 to 63.2% depending on the total score., Conclusion: This study demonstrated a significant association between knee and low back pain/disability along with other risk factors. The score we developed can be used to identify a population without any imaging modality who are at high risk of developing knee pain.
- Published
- 2019
- Full Text
- View/download PDF
32. Intraoperative medial joint laxity in flexion decreases patient satisfaction after total knee arthroplasty.
- Author
-
Azukizawa M, Kuriyama S, Nakamura S, Nishitani K, Lyman S, Morita Y, Furu M, Ito H, and Matsuda S
- Subjects
- Aged, Aged, 80 and over, Female, Follow-Up Studies, Health Status Indicators, Humans, Joint Instability diagnosis, Joint Instability psychology, Knee Joint physiopathology, Knee Joint surgery, Male, Middle Aged, Osteoarthritis, Knee physiopathology, Range of Motion, Articular, Treatment Outcome, Arthroplasty, Replacement, Knee, Intraoperative Complications diagnosis, Intraoperative Complications psychology, Joint Instability etiology, Osteoarthritis, Knee surgery, Patient Satisfaction statistics & numerical data
- Abstract
Introduction: The relationship between postoperative tibiofemoral ligament balance and patient satisfaction in total knee arthroplasty (TKA) has been explored previously. However, the optimal intraoperative medial-lateral ligament balance during knee flexion in terms of postoperative patient satisfaction remains unknown. We evaluated the effect of intraoperative flexion instability on patient satisfaction after TKA., Materials and Methods: This study consisted of 46 knees with varus osteoarthritis undergoing TKA. Medial-lateral component gaps at 0° knee extension and 90° flexion were measured intraoperatively using a knee balancer. Differences in postoperative patient outcomes at 3 weeks and 1 year were compared between medially tight knees in 90° flexion with a medial component gap of < 4 mm and medially loose knees in 90° flexion with a gap of ≥ 4 mm. Outcomes were measured using the 2011 Knee Society Scoring System (2011 KS)., Results: The median total 2011 KS score at 1 year postoperatively in the medially loose knees [median 97; interquartile range (IQR) 75-117] was significantly lower than that in the medially tight knees (median 128; IQR 104-139, P < 0.01), while preoperative and 3-week postoperative scores were similar. In addition, medial flexion gaps were not significantly associated with total 2011 KS scores before surgery or at 3 weeks postoperatively. However, at 1 year after surgery, medial component flexion gaps were negatively associated with the total 2011 KS score (R = - 0.42; P < 0.01) and the 2011 KS satisfaction subscale score (R = - 0.36; P = 0.01)., Conclusions: Excessive intraoperative medial joint laxity of ≥ 4 mm at 90° flexion progressively decreased patient satisfaction for 1 year. Since intraoperative medial laxity in flexion is likely to interfere with functional recovery after TKA, medial stabilization during TKA is important throughout knee flexion., Level of Evidence: Therapeutic study, Level III.
- Published
- 2018
- Full Text
- View/download PDF
33. Subchondral bone fragility with meniscal tear accelerates and parathyroid hormone decelerates articular cartilage degeneration in rat osteoarthritis model.
- Author
-
Morita Y, Ito H, Ishikawa M, Fujii T, Furu M, Azukizawa M, Okahata A, Tomizawa T, Kuriyama S, Nakamura S, Nishitani K, Yoshitomi H, and Matsuda S
- Subjects
- Animals, Bone Remodeling drug effects, Bone and Bones metabolism, Cartilage metabolism, Collagen Type X chemistry, Disease Models, Animal, Disease Progression, Hindlimb pathology, Immunohistochemistry, Male, Mast Cells metabolism, Matrix Metalloproteinase 13 metabolism, Meniscus injuries, Osteoarthritis metabolism, Parathyroid Hormone metabolism, Rats, Rats, Sprague-Dawley, X-Ray Microtomography, Bone and Bones pathology, Cartilage, Articular metabolism, Meniscus pathology, Osteoarthritis physiopathology
- Abstract
The aims of this study were to investigate the influence of subchondral bone fragility (SBF) on the progression of the knee osteoarthritis by using a novel rat model, and to examine the preventive effect of parathyroid hormone (PTH) on cartilage degeneration. First, 40 rats were assigned to the following four groups: Sham, SBF, Medial meniscal tear (MMT), and MMT + SBF groups. In SBF and MMT + SBF groups, we induced SBF by microdrilling the subchondral bone. Second, 10 additional rats were randomly assigned to the following two groups: MMT + SBF + saline and MMT + SBF + PTH groups. Osteoarthritic changes in the articular cartilage and subchondral bone were evaluated using safranin-O/fast green staining, matrix metalloproteinase-13 (MMP-13), and type X collagen immunohistochemistry, toluidine blue staining, and micro-CT scanning. The combination of SBF and meniscal tear increased the number of mast cells in the subchondral bone, and led to the abnormal subchondral bone microarchitecture, such as abnormally decreased trabecular number and increased trabecular thickness, compared with meniscal tear alone. Moreover, SBF with meniscal tear enhanced articular cartilage degeneration and increased the expression of MMP-13 and type X collagen, compared with meniscal tear alone. The administration of PTH decreased the number of mast cells in the subchondral bone and improved the microstructural parameters of the subchondral bone, and delayed the progression of articular cartilage degeneration. These results suggest that SBF is one of the factors underlying the osteoarthritis development, especially in knees with traumatic osteoarthritis, and that the administration of PTH is a potential therapeutic treatment for preventing OA progression. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1959-1968, 2018., (© 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.)
- Published
- 2018
- Full Text
- View/download PDF
34. How precisely does ultrasonographic evaluation reflect the histological status of the articular cartilage of the knee joint?
- Author
-
Maeguchi K, Ito H, Morita Y, Furu M, Fujii T, Azukizawa M, Okahata A, Nishitani K, Kuriyama S, Nakamura S, and Matsuda S
- Abstract
The thickness and the grade of the articular cartilages of the knee of 34 patients who underwent total knee arthroplasty were evaluated by ultrasound (US) and by histology. The US grade correlated with the histological grade and the thickness of the articular cartilage measured by US. The thickness measured by US was significantly correlated with that measured by histology for the medial condyle. The US thickness was significantly less than the histological thickness for thicker articular cartilages. US grading and the thickness of the articular cartilages evaluated by US is sufficiently reliable to indicate their histological status.
- Published
- 2018
- Full Text
- View/download PDF
35. Factors affecting walking ability in female patients with rheumatoid arthritis.
- Author
-
Morita Y, Ito H, Torii M, Hanai A, Furu M, Hashimoto M, Tanaka M, Azukizawa M, Arai H, Mimori T, and Matsuda S
- Subjects
- Aged, Arthritis, Rheumatoid drug therapy, Arthritis, Rheumatoid metabolism, C-Reactive Protein analysis, Female, Humans, Knee physiopathology, Linear Models, Methotrexate pharmacology, Methotrexate therapeutic use, Middle Aged, Risk Factors, Severity of Illness Index, Walking Speed drug effects, Arthritis, Rheumatoid pathology, Gait drug effects
- Abstract
Objective: To determine the factors associated with gait parameters in female patients with rheumatoid arthritis (RA)., Methods: The gait analysis was performed in a large cohort of RA patients, and three basic gait parameters (step length, cadence and gait speed) were calculated. Clinical and laboratory data were also collected. Factors associated with gait parameters were analyzed using multivariable linear regression in the three models with forced entry. Then, we divided those patients with Health Assessment Questionnaire disability index (HAQ) scores ≤ 0.5 into two groups according to their gait speed that were compared to identify the characteristics of patients with a good HAQ score but poor walking ability., Results: A total of 318 female patients were analyzed. Knee extension strength had the strongest positive association with all three gait parameters (P < 0.0001), while methotrexate use was also positively associated with all three gait parameters (step length: P < 0.05, cadence: P < 0.05 in model 1 and 2; P < 0.01 in model 3, gait speed: P < 0.01). The disease activity score was negatively associated with step length and gait speed (step length, gait speed: P < 0.01 in model 1 and 2; P < 0.05 in model 3). 26% of patients with good HAQ scores showed slow gait speed. Patients with good HAQ scores and slow gait speed had higher disease activity scores (P < 0.05) and lower knee extension strength (P < 0.0001) than those with good HAQ scores and normal gait speed., Conclusions: High knee extension strength, low disease activity and administration of methotrexate were strongly associated with good walking ability in female patients with RA. And, even if patients showed good HAQ scores, about quarter of those patients had poor walking ability, and they showed higher disease activity, lower knee extension strength, compared to the patients with normal gait speed.
- Published
- 2018
- Full Text
- View/download PDF
36. Nardilysin is involved in autoimmune arthritis via the regulation of tumour necrosis factor alpha secretion.
- Author
-
Fujii T, Nishi E, Ito H, Yoshitomi H, Furu M, Okabe N, Ohno M, Nishi K, Morita Y, Morita Y, Azukizawa M, Okahata A, Tomizawa T, Kimura T, and Matsuda S
- Abstract
Objective: Tumour necrosis factor alpha (TNF-α) plays an important role in rheumatoid arthritis (RA). TNF-α is synthesised as a membrane-anchored precursor and is fully activated by a disintegrin and metalloproteinase 17 (ADAM17)-mediated ectodomain shedding. Nardilysin (NRDC) facilitates ectodomain shedding via activation of ADAM17. This study was undertaken to elucidate the role of NRDC in RA., Methods: NRDC-deficient ( Nrdc
-/- ) mice and macrophage-specific NRDC-deficient ( NrdcdelM ) mice were examined in murine RA models, collagen antibody-induced arthritis (CAIA) and K/BxN serum transfer arthritis (K/BxN STA). We evaluated the effect of gene deletion or silencing of Nrdc on ectodomain shedding of TNF-α in macrophages or monocytes. NRDC concentration in synovial fluid from patients with RA and osteoarthritis (OA) were measured. We also examined whether local gene silencing of Nrdc ameliorated CAIA., Results: CAIA and K/BxN STA were significantly attenuated in Nrdc-/- mice and NrdcdelM mice. Gene deletion or silencing of Nrdc in macrophages or THP-1 cells resulted in the reduction of TNF-α shedding. The level of NRDC is higher in synovial fluid from RA patients compared with that from OA patients. Intra-articular injection of anti- Nrdc small interfering RNA ameliorated CAIA., Conclusion: These data indicate that NRDC plays crucial roles in the pathogenesis of autoimmune arthritis and could be a new therapeutic target for RA treatment., Competing Interests: Competing interests: None declared.- Published
- 2017
- Full Text
- View/download PDF
37. Subsidence of total ankle component associated with deterioration of an ankle scale in non-inflammatory arthritis but not in rheumatoid arthritis.
- Author
-
Iwata T, Ito H, Furu M, Ishikawa M, Azukizawa M, Yoshitomi H, Fujii T, Akiyama H, and Matsuda S
- Subjects
- Adult, Aged, Ankle Joint diagnostic imaging, Ankle Joint surgery, Arthroplasty, Replacement, Ankle methods, Female, Humans, Male, Middle Aged, Radiography, Reoperation statistics & numerical data, Treatment Outcome, Arthritis, Rheumatoid surgery, Arthroplasty, Replacement, Ankle adverse effects, Postoperative Complications epidemiology
- Abstract
Objectives: Modern three-component total ankle arthroplasty (TAA) has favorable clinical results and survival rates. However, radiographic deterioration and worsening of clinical symptoms may occur in patients with rheumatoid arthritis (RA) or non-inflammatory arthritis (NA). The associations between outcomes and clinical and radiological factors are not clear. We compared midterm clinical and radiographic outcomes after TAA between patients with RA and those with NA., Methods: Twenty-six TAAs were performed using a three-component prosthesis, the FINE Total Ankle System during the study period. Fourteen TAAs with 11 RA patients undergoing primary TAA were compared with twelve TAAs with 12 NA patients. Clinical and radiographic outcomes were evaluated before and after operation, and at the final follow-up., Results: The Japanese Society for Surgery of the Foot (JSSF) scale improved significantly following TAA in both groups (p = 0.0039 and 0.0156, respectively). Tibial subsidence, talar subsidence and age were significantly associated with postoperative JSSF score only in the NA group (p = 0.0027, 0.0017 and p < 0.0001, respectively). Stepwise regression analysis showed that talar subsidence was an independent predictor of a worse JSSF score in the NA group (F = 10.3)., Conclusions: The final clinical outcome was negatively influenced by talar subsidence in patients with NA, but not in those with RA.
- Published
- 2017
- Full Text
- View/download PDF
38. Correlation in the Coronal Angle between Knee and Hindfoot Was Observed in Patients with Rheumatoid Arthritis Unless Talocrural Joint Was Destroyed.
- Author
-
Nishitani K, Ito H, Shimozono Y, Furu M, Azukizawa M, Hashimoto M, Tanaka M, Mimori T, and Matsuda S
- Subjects
- Adult, Aged, Aged, 80 and over, Arthroplasty, Replacement, Knee methods, Female, Foot physiopathology, Humans, Male, Middle Aged, Ankle Joint physiopathology, Arthritis, Rheumatoid physiopathology, Knee physiopathology, Knee Joint physiopathology
- Abstract
The purpose of this study is to investigate the compensatory correlation between knee and hindfoot in patients with rheumatoid arthritis (RA). This cross-sectional study included 218 patients (407 lower extremities). Radiographs of the hindfoot and full-length posteroanterior hip-to-calcaneus standing radiographs were evaluated. The destruction of the hindfoot was evaluated using the Larsen grading system. The coronal angular deformity of the knee and hindfoot was evaluated by the femorotibial angle (FTA) and the angle between the tibial shaft and the entire hindfoot (tibiohindfoot angle, THFA). The correlation between FTA and THFA was determined by Pearson's coefficient. For all patients, FTA correlated to THFA ( R = 0.28, p < 0.001). The correlation was observed as long as the talocrural joint was preserved (Larsen grade ≤ 2), even if the subtalar joint had been destroyed (Larsen grade ≥ 3). However, the correlation was not observed when the talocrural joint was destroyed (Larsen grade ≥ 3, R = -0.02, p = 0.94). The pain in the hindfoot did not correlate with FTA or THFA. In conclusion, a compensatory deformity of the hindfoot against the deformity of the knee was observed in RA, and the correlation was lost when talocrural joint was destroyed.
- Published
- 2017
- Full Text
- View/download PDF
39. Quadriceps strength affects patient satisfaction after total knee arthroplasty.
- Author
-
Furu M, Ito H, Nishikawa T, Nankaku M, Kuriyama S, Ishikawa M, Nakamura S, Azukizawa M, Hamamoto Y, and Matsuda S
- Subjects
- Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Arthroplasty, Replacement, Knee, Muscle Strength, Patient Satisfaction, Quadriceps Muscle physiology, Walking physiology
- Abstract
Background: Total knee arthroplasty is one of the most successful surgeries with respect to relieving pain and restoring function of the knee. However, some studies have reported that patients are not always satisfied with their results after total knee arthroplasty. The aim of this study was to determine whether the muscle strength around the knee joint and the walking status influence patients' expectations and satisfaction before and after total knee arthroplasty., Methods: We evaluated 28 patients who underwent 30 primary total knee arthroplasties from March 2012 to June 2013. We assessed patient-reported scores using the 2011 Knee Society Scoring System, knee extensor and flexor strength, the 10-m walking test, and the timed up-and-go test. All assessments were performed preoperatively and 1 year after total knee arthroplasty. We determined the correlation between the patient-reported scores and each variable., Results: Preoperative patient satisfaction was significantly correlated with knee symptoms and functional activities, but not with muscle strength or walking status. Postoperative patient satisfaction was significantly correlated with knee symptoms, functional activities, knee extensor strength, and walking status, including the 10-m walking test and timed up-and-go test, after total knee arthroplasty. In stepwise regression analysis, predictors of patient satisfaction with total knee arthroplasty were knee symptoms, functional ability, and knee extensor strength., Conclusions: Our study demonstrates that pain relief and restoration of functional activity are highly correlated with increasing patient satisfaction after total knee arthroplasty. The results also indicate that the quadriceps is important for patient satisfaction and restoration of functional activity following total knee arthroplasty., (Copyright © 2015 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved.)
- Published
- 2016
- Full Text
- View/download PDF
40. Cross-cultural adaptation and validation of the Japanese version of the new Knee Society Scoring System for osteoarthritic knee with total knee arthroplasty.
- Author
-
Hamamoto Y, Ito H, Furu M, Ishikawa M, Azukizawa M, Kuriyama S, Nakamura S, and Matsuda S
- Subjects
- Arthroplasty, Replacement, Knee rehabilitation, Cross-Cultural Comparison, Humans, Osteoarthritis, Knee diagnosis, Osteoarthritis, Knee surgery, Quality of Life, Reproducibility of Results, Severity of Illness Index, Surveys and Questionnaires, Adaptation, Psychological, Arthroplasty, Replacement, Knee psychology, Disability Evaluation, Osteoarthritis, Knee psychology, Psychometrics methods, Societies, Medical, Translating
- Abstract
Background: The purposes of this study were to translate the new Knee Society Score (KSS) into Japanese and to evaluate the construct and content validity, test-retest reliability, and internal consistency of the Japanese version of the new KSS., Methods: The Japanese version of the KSS was developed according to cross-cultural guidelines by using the "translation-back translation" method to ensure content validity. KSS data were then obtained from patients who had undergone total knee arthroplasty (TKA). The psychometric properties evaluated were as follows: for feasibility, response rate, and floor and ceiling effects; for construct validity, internal consistency using Cronbach's alpha, and correlations with quality of life. Construct validity was evaluated by using Spearman's correlation coefficient to quantify the correlation between the KSS and the Japanese version of the Oxford 12-item Knee Score or Short Form 36 Health Survey (SF-36) questionnaires., Results: The Japanese version of the KSS was sent to 93 consecutive osteoarthritic patients who underwent primary TKA in our institution. Fifty-five patients completed the questionnaires and were included in this study. Neither a floor nor ceiling effect was observed. The reliability proved excellent in the majority of domains, with intraclass correlation coefficients of 0.65-0.88. Internal consistency, assessed by Cronbach's alpha, was good to excellent for all domains (0.78-0.94). All of the four domains of the KSS correlated significantly with the Oxford 12-item Knee Score. The activity and satisfaction domains of the KSS correlated significantly with all and the majority of subscales of the SF-36, respectively, whereas symptoms and expectation domains showed significant correlations only with bodily pain and vitality subscales and with the physical function, bodily pain, and vitality subscales, respectively., Conclusions: The Japanese version of the new KSS is a valid, reliable, and responsive instrument to capture subjective aspects of the functional symptoms and abilities of patients who undergo TKA.
- Published
- 2015
- Full Text
- View/download PDF
41. Serological and Progression Differences of Joint Destruction in the Wrist and the Feet in Rheumatoid Arthritis - A Cross-Sectional Cohort Study.
- Author
-
Hamamoto Y, Ito H, Furu M, Hashimoto M, Fujii T, Ishikawa M, Yamakawa N, Terao C, Azukizawa M, Iwata T, Mimori T, and Matsuda S
- Subjects
- Adult, Aged, Aged, 80 and over, Arthritis, Rheumatoid diagnostic imaging, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Radiography, Arthritis, Rheumatoid blood, Foot Joints diagnostic imaging, Wrist Joint diagnostic imaging
- Abstract
Objective: To investigate clinical and radiological differences between joint destruction in the wrist and the feet in patients with RA., Methods: A cross-sectional clinical study was conducted in an RA cohort at a single institution. Clinical data included age, sex and duration of disease. Laboratory data included sero-positivity for anti-cyclic citrullinated peptide (CCP) antibody and RF. Radiological measurements included Larsen grades and the modified Sharp/van der Heijde method (SHS) for the hands/wrists and the feet. Statistical analyses were performed using the Kruskal-Wallis H-test, a dummy variable linear regression model and multivariate logistic regression analysis with 95% confidence interval and odds ratios., Results: A total of 405 patients were enrolled, and 314 patients were analysed in this study. The duration of disease in the foot-dominant group was significantly less than that in the wrist-dominant group. When patients were subdivided by duration of disease, the Larsen grade of the feet was significantly higher than that of the wrist in the first quadrant subgroup, but this was reversed with increasing duration of disease. Anti-CCP status was a significant predictive factor for joint destruction in the wrist but not in the feet, while RF status was not predictive in either the wrist or the feet., Conclusions: Joint destruction in the feet started earlier than in the wrist, but the latter progresses faster with increasing duration of disease. Anti-CCP status predicts joint destruction in the wrist better than in the feet.
- Published
- 2015
- Full Text
- View/download PDF
42. Delayed wound healing after forefoot surgery in patients with rheumatoid arthritis.
- Author
-
Ishie S, Ito H, Azukizawa M, Furu M, Ishikawa M, Ogino H, Hamamoto Y, and Matsuda S
- Subjects
- Adult, Aged, Arthritis, Rheumatoid surgery, Arthrodesis, Arthroplasty, Female, Foot Deformities physiopathology, Forefoot, Human surgery, Humans, Male, Middle Aged, Treatment Outcome, Arthritis, Rheumatoid physiopathology, Foot Deformities surgery, Forefoot, Human physiopathology, Metatarsal Bones surgery, Wound Healing physiology
- Abstract
Objective: To elucidate the systemic and local risk factors and the effect of surgical procedures for delayed wound healing after forefoot surgery in patients with rheumatoid arthritis (RA)., Methods: Fifty forefoot surgeries were performed in 39 patients using resection arthroplasty or a joint-preserving procedure (25 feet for each procedure). The associations between the occurrence of delayed wound healing and clinical variables, radiological assessment, or surgical procedures were analyzed., Results: Delayed wound healing was recorded in nine feet of eight patients. The duration of RA was significantly longer in the delayed healing group than that in the healed group. Age, sex, smoking history, concomitant diabetes, and RA medication did not differ between the groups. Radiological evaluation showed significant differences between groups in metatarsophalangeal dorsal flexion angle. The shortened length of the fourth and the fifth metatarsal bones affected the occurrence of the complication. The joint-preserving procedure had significantly less delayed wound healing compared with resection arthroplasty., Conclusions: Preoperative dorsoplantar deformity and perioperative tissue damage can cause delayed wound healing after forefoot surgery in RA patients.
- Published
- 2015
- Full Text
- View/download PDF
43. Failure of triiodothyronine to prevent propylthiouracil-induced hypothyroidism and goiter in fetal sheep.
- Author
-
Horger EO 3rd, Kenimer JG, Azukizawa M, Hershman JM, Kansal PC, and Leaming AB
- Subjects
- Animals, Female, Goiter chemically induced, Hypothyroidism chemically induced, Organ Size, Pregnancy, Sheep, Thyroid Gland drug effects, Thyrotropin blood, Thyroxine blood, Disease Models, Animal, Fetal Diseases prevention & control, Goiter prevention & control, Hypothyroidism prevention & control, Propylthiouracil, Triiodothyronine therapeutic use
- Abstract
Administration of propylthiouracil (PTU) to pregnant, third trimester sheep led to decreasing serum thyroxine and increasing serum thyroid-stimulating hormone in both mothers and fetuses. Hypothyroidism appeared more pronounced in the fetuses than in the ewes, and goiter formation was observed in all fetuses exposed to PTU. Concomitant administration of triiodothyronine failed to protect the fetuses from the effects of PTU.
- Published
- 1976
44. [Circadian rhythm of TSH in man].
- Author
-
Azukizawa M, Ota M, Kumahara Y, and Miyai K
- Subjects
- Female, Humans, Male, Sleep, Circadian Rhythm, Thyrotropin blood
- Published
- 1978
45. [Radioimmunoassay of TBG im mophase-TBG kit (author's transl)].
- Author
-
Azukizawa M, Miki T, Kumahara Y, Miyai K, and Ashida S
- Subjects
- Female, Humans, Pregnancy, Radioimmunoassay methods, Reagent Kits, Diagnostic, Thyroxine-Binding Proteins analysis
- Published
- 1981
46. Plasma thyrotropin, thyroxine, and triiodothyronine relationships in man.
- Author
-
Azukizawa M, Pekary AE, Hershman JM, and Parker DC
- Subjects
- Adult, Circadian Rhythm, Female, Humans, Male, Radioimmunoassay, Somatostatin pharmacology, Time Factors, Thyrotropin blood, Thyroxine blood, Triiodothyronine blood
- Abstract
The physiologic relationships of plasma TSH, T4 and T3 levels measured every 20 min in seven healthy young men and one healthy young woman have been investigated. A nocturnal TSH surge was observed in all subjects on both nights of the 36-48 h baseline observation period. In males the maximum plasma TSH value occurred at 2300 h. The mean peak TSH level was 2.0 +/- 0.3 (se) muU/ml compared with a mean of 1.3 +/- 0.9 muU/ml for the entire baseline records of the 8 subjects. The effect of iv infusion of 32-1000 mug of somatostatin (SRIF) for 1 1/2-3 h was investigated in four of the male subjects during 2 or 4 consecutive nights following the control period. Temporal relationships between the hormonal fluctuations observed throughout the control period and during the nights of SRIF infusion were investigated using time series analysis and Student's t test. Rapid fluctuations of plasma T4 and T3 concentration were noted, even when corrected for changes in total protein concentration, with an average coefficient of variation of 10% for T3 and 12% for T4. No increment of plasma T4 or T3 followed the nocturnal TSH surge nor were the rapid fluctuations of the thyroid hormones altered by the TSH surge. SRIF infusion commencing at 2300 h suppressed the elevated TSH levels (P is less than 0.01) while similar infusions begun at 2100 h blocked the expected nocturnal TSH rise observed during control periods in male subjects. Plasma T4 and T3 levels were not significantly affected by the administration of SRIF. The relationship of the rapid plasma T4 and T3 variations to postural changes was investigated in four euthyroid male subjects. Serum levels of TSH, T4 and T3 and total protein were determined at 15 min intervals while postural changes were carefully monitored. The ratios of T4 and T3 to total protein were relatively stable (3-4% coefficient of variation) when the subjects were kept in a supine and motionless position. A 50 mug bolus infusion of T4 raised the basal T4 level by only 1-2 mug/dl. The data suggest that short-term fluctuation of plasma T4 and T3 result from changes in protein concentration due to hemodynamic responses to alteration of posture and physical activity and not to pulsatile secretion of T4 and T3.
- Published
- 1976
- Full Text
- View/download PDF
47. A comparison of thyroxine and desicatted thyroid in patients with primary hypothyroidism.
- Author
-
Sawin CT, Hershman JM, Fernandez-Garcia R, Ghazvinian S, Ganda OP, and Azukizawa M
- Subjects
- Dose-Response Relationship, Drug, Humans, Thyroxine blood, Triiodothyronine blood, Hypothyroidism drug therapy, Thyroid (USP) therapeutic use, Thyroid Hormones therapeutic use, Thyrotropin blood, Thyrotropin-Releasing Hormone, Thyroxine therapeutic use
- Published
- 1978
- Full Text
- View/download PDF
48. [Experimental studies on the clinical application of human TSH radiommunoassay].
- Author
-
Azukizawa M, Miyai K, Azukizawa H, and Kumahara Y
- Subjects
- Humans, Thyroid Diseases blood, Radioimmunoassay methods, Thyrotropin blood
- Published
- 1975
49. [Proceedings: The pituitary-thyroid system in pregnant rats].
- Author
-
Kojima A and Azukizawa M
- Subjects
- Animals, Female, Pregnancy, Rats, Thyrotropin blood, Thyroxine blood, Triiodothyronine blood, Pituitary Gland physiology, Pregnancy, Animal, Thyroid Gland metabolism
- Published
- 1974
50. [Radioimmunoassay of serum TSH in hypothalamo-pituitary dysfunctions and thyroid diseases].
- Author
-
Miyai K, Azukizawa M, Azukizawa H, Hosokawa M, and Nishi K
- Subjects
- Endocrine System Diseases blood, Humans, Pituitary Diseases blood, Hypothalamo-Hypophyseal System, Radioimmunoassay methods, Thyroid Diseases blood, Thyrotropin blood
- Published
- 1975
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.