Search

Your search keyword '"Bártová, Eva"' showing total 541 results
Start Over Author "Bártová, Eva"
541 results on '"Bártová, Eva"'

8. Correction: Svobodova et al. N 6 -Adenosine Methylation in RNA and a Reduced m 3 G/TMG Level in Non-Coding RNAs Appear at Microirradiation-Induced DNA Lesions. Cells 2020, 9 , 360.

Author

Kovaříková, Alena Svobodová, Stixová, Lenka, Kovařík, Aleš, Komůrková, Denisa, Legartová, Soňa, Fagherazzi, Paolo, and Bártová, Eva

Subjects
DNA damage, WESTERN immunoblotting, NON-coding RNA, RNA methylation, ZIP codes
Abstract

The correction notice for the article "N6-Adenosine Methylation in RNA and a Reduced m3G/TMG Level in Non-Coding RNAs Appear at Microirradiation-Induced DNA Lesions" addresses errors in affiliation details and a figure. The correction includes updating the zip code for the Institute of Biophysics of the Czech Academy of Sciences and replacing incorrect bands in Figure 6. The authors confirm that these corrections do not impact the scientific conclusions of the study. The article focuses on the levels of m6A RNAs in different cell types following microirradiation, highlighting variations in RNA accumulation at DNA lesions. [Extracted from the article]

Published
2024
Full Text
View/download PDF

12. Contributors

Author

Aranda, Sergi, primary, Arcidiacono, Orazio Angelo, additional, Artus, Jerome, additional, Bártová, Eva, additional, Battle, Stephanie L., additional, Bavli, Danny, additional, Biran, Alva, additional, Branco, Miguel R., additional, Bressan, Raul Bardini, additional, Caporale, Nicolò, additional, Di Croce, Luciano, additional, Dion, Camille, additional, Gonzalez, Inma, additional, Hawkins, R. David, additional, Kozulin, Chen, additional, Krejčí, Jana, additional, Legartová, Soňa, additional, Leitch, Harry G., additional, Lopez-Tobon, Alejandro, additional, Mermoud, Jacqueline E., additional, Meshorer, Eran, additional, Navarro, Pablo, additional, Owens, Nick D.L., additional, Platania, Angeliki, additional, Pollard, Steven M., additional, Poot, Raymond A., additional, Ram, Oren, additional, Schlesinger, Sharon, additional, Sexton, Tom, additional, Stixova, Lenka, additional, Testa, Giuseppe, additional, and Trattaro, Sebastiano, additional

Published
2020
Full Text
View/download PDF

32. Cell Differentiation and Aging Lead To Up-Regulation of FTO, While the ALKBH5 Protein Level Was Stable During Aging but Up-Regulated During in vitro-Induced Cardiomyogenesis.

Author

KREJČÍ, Jana, ARCIDIACONO, Orazio Angelo, ČEGAN, Radim, RADASZKIEWICZ, Katarzyna, PACHERNÍK, Jiří, PIRK, Jan, PEŠL, Martin, FILA, Petr, and BÁRTOVÁ, Eva

Subjects
AGING, CELL differentiation, EPIGENETICS, HEART development, DEMETHYLATION
Abstract

FTO and ALKBH5 proteins are essential erasers of N6-adenosine methylation in RNA. We studied how levels of FTO and ALKBH5 proteins changed during mouse embryonic development, aging, cardiomyogenesis, and neuroectodermal differentiation. We observed that aging in male and female mice was associated with FTO up-regulation in mouse hearts, brains, lungs, and kidneys, while the ALKBH5 level remained stable. FTO and ALKBH5 proteins were up-regulated during experimentally induced cardiomyogenesis, but the level of ALKBH5 protein was not changed when neuroectodermal differentiation was induced. HDAC1 depletion in mouse ES cells caused FTO down-regulation. In these cells, mRNA, carrying information from genes that regulate histone signature, RNA processing, and cell differentiation, was characterized by a reduced level of N6-adenosine methylation in specific gene loci, primarily regulating cell differentiation into neuroectoderm. Together, when we compared both RNA demethylating proteins, the FTO protein level undergoes the most significant changes during cell differentiation and aging. Thus, we conclude that during aging and neuronal differentiation, m6A RNA demethylation is likely regulated by the FTO protein but not via the function of ALKBH5. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

36. PARP-dependent and NAT10-independent acetylation of N4-cytidine in RNA appears in UV-damaged chromatin.

Author

Svobodová Kovaříková, Alena, Stixová, Lenka, Kovařík, Aleš, and Bártová, Eva

Subjects
DNA repair, RNA modification & restriction, RNA, DNA damage, ACETYLATION, IRRADIATION, DOSE-response relationship (Radiation)
Abstract

RNA modifications have been known for many years, but their function has not been fully elucidated yet. For instance, the regulatory role of acetylation on N4-cytidine (ac4C) in RNA can be explored not only in terms of RNA stability and mRNA translation but also in DNA repair. Here, we observe a high level of ac4C RNA at DNA lesions in interphase cells and irradiated cells in telophase. Ac4C RNA appears in the damaged genome from 2 to 45 min after microirradiation. However, RNA cytidine acetyltransferase NAT10 did not accumulate to damaged sites, and NAT10 depletion did not affect the pronounced recruitment of ac4C RNA to DNA lesions. This process was not dependent on the G1, S, and G2 cell cycle phases. In addition, we observed that the PARP inhibitor, olaparib, prevents the recruitment of ac4C RNA to damaged chromatin. Our data imply that the acetylation of N4-cytidine, especially in small RNAs, has an important role in mediating DNA damage repair. Ac4C RNA likely causes de-condensation of chromatin in the vicinity of DNA lesions, making it accessible for other DNA repair factors involved in the DNA damage response. Alternatively, RNA modifications, including ac4C, could be direct markers of damaged RNAs. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

46. Seroprevalence of Theileria equi, Babesia caballi, and Trichinella spp. infections in horses and donkeys from Nigeria, West Africa

Author

Kašpárková Nikola, Sedlák Kamil, Budíková Marie, Kamani Joshua, Mohammed J Samaila, and Bártová Eva

Subjects
Veterinary medicine, food.ingredient, Babesia caballi, 040301 veterinary sciences, Trichinella, Horse meat, ved/biology.organism_classification_rank.species, Babesia, Cattle Diseases, Nigeria, Trichinosis, 0403 veterinary science, food, Food Animals, Seroepidemiologic Studies, Babesiosis, Theileria, parasitic diseases, medicine, Animals, Seroprevalence, Helminths, Horses, biology, ved/biology, Zoonosis, 0402 animal and dairy science, Horse, Trichinellosis, Equidae, 04 agricultural and veterinary sciences, biology.organism_classification, medicine.disease, 040201 dairy & animal science, Theileriasis, Africa, Western, Cattle, Horse Diseases, Animal Science and Zoology
Abstract

The protozoan parasites Theileria equi and Babesia caballi, transmitted by ticks, cause equine piroplasmosis, the most prevalent tick-borne disease in equids. Trichinellosis is a worldwide food-borne zoonosis caused by helminth Trichinella spp. that can lead to serious disease in humans, with fatal outcome. Although the infection is rare in horses, it deserves attention due to the increasing use of horse meat as a source of protein for humans. Horse trichinellosis is caused by several Trichinella species, most commonly by T. spiralis. The aim of the study was to determine the prevalence of antibodies to T. equi, B. caballi and Trichinella spp. in equids from three states of Northern Nigeria. Serum samples were collected from 139 clinically healthy animals, comprising 115 horses and 24 donkeys. Antibodies to T. equi and B. caballi were detected in serum by competitive-inhibition enzyme-linked immunosorbent assay (cELISA) and antibodies to Trichinella spp. by ELISA. Antibodies to T. equi were detected in 34% of equids (41% horses and 0% donkeys), antibodies to B. caballi in 9% of equids (8% horses and 13% donkeys), and antibodies to Trichinella spp. in 4% of equids (4% horses and 0% donkeys). There was co-infection of T. equi and B. caballi in 1% of horses and co-infection of T. equi and Trichinella spp. in 2.6% of horses. This is the first report on seroprevalence of Trichinella spp. in equids from Northern Nigeria.

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results