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1. Impact of vaccination on the presence and severity of symptoms in hospitalized patients with an infection of the Omicron variant (B.1.1.529) of the SARS-CoV-2 (subvariant BA.1)

Author

Beraud, Guillaume, Bouetard, Laura, Civljak, Rok, Michon, Jocelyn, Tulek, Necla, Lejeune, Sophie, Millot, Romain, Garchet-Beaudron, Aurélie, Lefebvre, Maeva, Velikov, Petar, Festou, Benjamin, Abgrall, Sophie, Lizatovic, Ivan K., Baldolli, Aurélie, Esmer, Huseyin, Blanchi, Sophie, Froidevaux, Gabrielle, Kapincheva, Nikol, Faucher, Jean-François, Duvnjak, Mario, Afşar, Elçin, Švitek, Luka, Yarimoglu, Saliha, Yarimoglu, Rafet, Janssen, Cécile, and Epaulard, Olivier

Published
2023
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8. Hydroxychloroquine in mild-to-moderate coronavirus disease 2019: a placebo-controlled double blind trial

Author

Brangier, Antoine, Codron, Philippe, Lemée, Jean Michel, Pichon, Virginie, Dhersin, Robin, Urbanski, Geoffrey, Lavigne, Christian, Courtois, Roxane, Danielou, Hélène, Lebreton, Jonathan, Vatan, Rémi, Crochette, Nicolas, Lainé, Jean-Baptiste, Perez, Lucia, Blanchi, Sophie, Hitoto, Hikombo, Bernard, Louis, Maillot, François, Marchand Adam, Sylvain, Talarmin, Jean-Philippe, Gaigneux, Emeline, Motte-Vincent, Pauline, Morrier, Marine, Merrien, Dominique, Bleher, Yves, Flori, Maxime, Ducet-Boiffard, Amélie, Colin, Orane, Février, Ronan, Thill, Pauline, Tetart, Macha, Demaeght, François, Lafond-Desmurs, Barthelemy, Pradier, Maxime, Meybeck, Agnes, Picaud, Marjorie, Prazuck, Thierry, Chapelet, Guillaume, Rouaud, Agnès, Le Turnier, Paul, Sunder, Simon, Lorleac'h, Aurélien, Dollon, Christophe, Jacquet, Antoine, Le Vely, Francois, Gazeau, Pierre, Ansart, Séverine, Roger, Hélène, Laterza, François, Buzelé, Rodolphe, Tahmi, Fella, Lepeule, Raphael, Lacombe, Karine, Lefebvre, Bénédicte, Célarier, Thomas, Gagneux-Brunon, Amandine, Botelho-Nevers, Elisabeth, Bernard, Marc, Garnier, Camille, Mourguet, Morgane, Pugnet, Gregory, Vienne-Noyes, Sara, Martin-Blondel, Guillaume, Delobel, Pierre, Grouteau, Gaspard, Debard, Alexa, Guilleminault, Laurent, Arias, Pauline, Chakvetadze, Catherine, Flateau, Clara, Kopp, Aude, Putot, Alain, Barben, Jeremy, Mouries Martin, Suzanne, Nuss, Valentine, Piroth, Lionel, Claessens, Yann-Erick, Hentgen, Veronique, Martinot, Martin, Bach-Bunner, Maxime, Bonijoly, Thomas, Gravier, Simon, Michel, Jean-Marc, Andreu, Mathilde, Roriz, Mélanie, Baldolli, Aurélie, Brochard, Julia, Grossi, Olivier, Pineau, Samuel, Brisset, Josselin, Desvaux, Edouard, Gondran, Guillaume, Faucher, Jean-François, Quesnel, Paul-Antoine, Bezanahary, Holy, Danthu, Clément, Gutierrez, Blandine, Ly, Kim, Simonneau, Yannick, Cypierre, Anne, Pinet, Pauline, Durox, Hélène, Ducroix-Roubertou, Sophie, Genet, Claire, Beraud, Guillaume, Le Moal, Gwenael, Rammaert, Blandine, Lanoix, Jean-Philippe, Andrejak, Claire, Joseph, Cédric, Soriot-Thomas, Sandrine, Dhote, Robin, Abad, Sébastien, Benainous, Ruben, Boitiaux, Jean-François, Briend, Guillaume, Gonfroy, Celine, Harent, Stanislas, Lagrange, Aurore, Tone, Alina, Wayenberg, Laura, Desoutter, Sophie, Ettahar, Nicolas, Gey, Thomas, Leroy, Vincent, Gaillard, Sacha, Toma, Andrea, Broussier, Amaury, Etienne, Sandrine, Spivac, Yann, Martha, Benoit, Roch, Nathalie, Diaz, Pierre, N’guyen Baranoff, Danièle, Rebaudet, Stanislas, Jourda, François, Zeller, Valérie, Bienvenu, Boris, Boyer, Arnaud, Pellier, Isabelle, Mercat, Alain, Darsonval, Astrid, Blanchet, Odile, Custaud, Marc-Antoine, Lefeuvre, Caroline, Parot-Schinkel, Elsa, Vielle, Bruno, Briet, Marie, Roy, Pierre-Marie, Dubée, Vincent, Guidet, Bertrand, Mismetti, Patrick, Vicaut, Eric, Sanchez, Olivier, Girard, Philippe, Elias, Antoine, Couturaud, Francis, Gable, Béatrice, Lazareff, Sybille, Carballido, Loïc, Hue, Catherine, Chrétien, Jean-Marie, Goraguer, Adrien, Eeckhoutte, Lucie van, Abbara, Chadi, Boucher, Sophie, Devaud, Edouard, Robineau, Olivier, Rispal, Patrick, Guimard, Thomas, d’Anglejean, Emma, and Diamantis, Sylvain

Published
2021
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9. Neurologic manifestations associated with COVID-19: a multicentre registry

Author

Abgrall, Sophie, Alby-Laurent, Fanny, Allou, Thibault, Amevigbe, Joséphine, Amarguellay, Hanifa, Alloussi, Nabil, Baille, Guillaume, Barbaz, Mathilde, Bekri, Imen, Bencherif, Lamia, Bensaadi, Samia, Beraud, Guillaume, Bizot, Alexandra, Bottin, Laure, Bruneel, Fabrice, Camdessanche, Jean-Philippe, Chauffier, Jeanne, Csajaghy, Jean-Philippe, De Broucker, Chloé, De Broucker, Thomas, Defebvre, Luc, Delorme, Cécile, Dembloque, Elodie, Derache, Nathalie, Dereeper, Olivier, Derollez, Céline, Descotes-Genon, Cécile, Desestret, Virginie, Devaux, Mathilde, Dubuc, Lydie, Edan, Gilles, Fickl, Andréa, Fraisse, Thibault, Gugenheim, Michel, Hankiewicz, Karolina, Hansmann, Yves, Hautecloque-Raysz, Geoffroy, Henry, Carole, Jobard, Stéphanie, Jouan, Fanny, Kwiatkowski, Arnaud, Lalu, Thibault, Landre, Sophie, Lannuzel, Annie, Leguilloux, Johan, Lejeune, Camille, Liegeois, Clémence, Mahy, Sophie, Marey, Jonathan, Maury, Alexandra, Meppiel, Elodie, Michel, Laure, Mitri, Rita, Moulin, Chloé, Moulin, Solène, Peiffer-Smadja, Nathan, Omarjee, Asma, Ozsancak, Canan, Perrin, Peggy, Petitgas, Paul, Pico, Fernando, Poupard, Marie, Rabier, Valérie, Rizzato, Camille, Roos, Caroline, Saison, Julien, Sayre, Naomi, Sedillot, Nicolas, Sellal, François, Servan, Jérôme, Storey, Caroline, Suchet, Laurent, Tarteret, Paul, Tattevin, Pierre, Thiebaut, Mathilde, Vaduva, Claudia, Varlan, David, Wang, Adrien, Zarrouk, Virginie, Gorza, Lucas, SellaI, François, and de Broucker, Thomas

Published
2021
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10. How Should we Use Multicolumn Spinal Cord Stimulation to Optimize Back Pain Spatial Neural Targeting? A Prospective, Multicenter, Randomized, Double-Blind, Controlled Trial (ESTIMET Study)

Author

Rigoard, Philippe, Billot, Maxime, Ingrand, Pierre, Durand-Zaleski, Isabelle, Roulaud, Manuel, Peruzzi, Philippe, Dam Hieu, Phong, Voirin, Jimmy, Raoul, Sylvie, Page, Philippe, Djian, Marie-Christine, Fontaine, Denys, Lantéri-Minet, Michel, Blond, Serge, Buisset, Nadia, Cuny, Emmanuel, Cadenne, Myriam, Caire, François, Ranoux, Danièle, Mertens, Patrick, Naous, Hussein, Simon, Emile, Emery, Evelyne, Béraud, Guillaume, Debiais, Françoise, Durand, Géraldine, Serrie, Alain, Diallo, Bakari, Bulsei, Julie, Ounajim, Amine, Nivole, Kevin, Duranton, Sophie, Naiditch, Nicolas, Monlezun, Olivier, and Bataille, Benoit

Published
2021
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11. Community-acquired bacterial meningitis in adults: in-hospital prognosis, long-term disability and determinants of outcome in a multicentre prospective cohort

Author

Duval, Xavier, Hoen, Bruno, Mourvillier, Bruno, Ploy, Marie-Cécile, Tubiana, Sarah, Varon, Emmanuelle, Caron, François, Bollaert, Pierre-Edouard, Gaillot, Olivier, Taha, Muhamed-Kheir, Poyart, Claire, Bonacorsi, Stephane, Vandenesch, François, Cambau, Emmanuelle, Lecuit, Marc, Gravet, Alain, Frachet, Bruno, Broucker, Thomas De, Levy Bruhl, Daniel, Raffi, François, Anguel, Nadia, Argaud, Laurent, Arista, Sophie, Armand-Lefevre, Laurence, Balavoine, Stéphanie, Baraduc, Régine, Barnaud, Guilène, Beraud, Guillaume, Bernard, Louis, Bernars, Georges, Bertei, Dominique, Bessede, Emilie, Billard Pomares, Typhaine, Biron, Charlotte, Bland, Stéphane, Boileau, Julien, Boubeau, Patrice, Bourdon, Sandra, Bousquet, Aurore, Boyer, Sophie, Bozorg-Grayeli, Alexis, Bret, Laurent, Bretonniere, Cédric, Bricaire, François, Brocas, Elsa, Brun, Michel, Buret, Jennifer, Burucoa, Christophe, Cabalion, Jean, Cabon, Mathieu, Camuset, Guillaume, Canevet, Christophe, Carricajo, Anne, Castan, Bernard, Caumes, Eric, Cazanave, Charles, Chabrol, Amélie, Challan-Belval, Thibaut, Chanteperdrix-Marillier, Vanessa, Chaplain, Chantal, Charlier-Woerther, Caroline, Chaussade, Hélène, Chirouze, Catherine, Clair, Bernard, Colot, Julien, Conil, Jean-Marie, Cordel, Hugues, Cormier, Philippe, Cousson, Joël, Cronier, Pierrick, Cua, Eric, Dao-Dubremetz, Anne, Dargere, Sylvie, Degand, Nicolas, Dekeyser, Sophie, Delaune, Deborah, Denes, Eric, Dequin, Pierre-Francois, Descamps, Diane, Descloux, Elodie, Desmaretz, Jean-Luc, Diehl, Jean-Luc, Dimet, Jérôme, Dinh, Aurélien, Escaut, Lelia, Fabe, Claude, Faibis, Frédéric, Flateau, Clara, Fonsale, Nathalie, Forestier, Emmanuel, Fortineau, Nicolas, Gagneux-Brunon, Amandine, Garandeau, Garcia, Magali, Garot, Denis, Gaudry, Stéphane, Goehringer, François, Gregoire-Faucher, Valérie, Grosset, Marine, Gubavu, Camélia, Gueit, Isabelle, Guelon, Dominique, Guimard, Thomas, Guinard, Jérôme, Hadou, Tahar, Helene, Jean-Pierre, Henard, Sandrine, Henry, Benoit, Hochart, Anne-Cécile, Illes, Gabriela, Jaffuel, Sylvain, Jarrin, Irène, Jaureguy, Françoise, Joseph, Cédric, Juvin, Marie-Emmanuelle, Kayal, Samer, Lacassin, Flore, Lamaury, Isabelle, Lanotte, Philippe, Laurens, Etienne, Laurichesse, Henri, Le Brun, Cécile, Le Moing, Vincent, Le Turnier, Paul, Lecuyer, Hervé, Ledru, Sylvie, Legrix, Céline, Lemaignen, Adrien, Lemble, Chantal, Lemee, Ludovic, Lesens, Olivier, Levast, Marion, Lhommet, Claire, Males, Silvija, Malpote, Edith, Martin-Blondel, Guillaume, Marx, Matthieu, Masson, Raphael, Matray, Olivier, Mbadi, Aurore, Mechai, Frédéric, Mellon, Guillaume, Merens, Audrey, Meyohas, Marie Caroline, Michon, Adrien, Mootien Yoganaden, Joy, Morquin, David, Mouly, Stéphane, Mrozek, Natacha, Nguyen, Sophie, Nguyen, Yohan, Ogielska, Maja, Oziol, Eric, Page, Bernard, Patrat-Delon, Solène, Patry, Isabelle, Pechinot, André, Picot, Sandrine, Pierrejean, Piroth, Lionel, Plassart, Claire, Plessis, Patrice, Portel, Laurent, Poubeau, Patrice, Poupard, Marie, Prazuck, Thierry, Quaesaet, Luc, Ramanantsoa, Adriatsiferana, Rapp, Christophe, Raskine, Laurent, Raymond, Josette, Revest, Matthieu, Riche, Agnès, Robaday-Voisin, Stéphanie, Robin, Frédéric, Romaszko, Jean-Pierre, Rousseau, Florence, Roux, Anne-Laure, Royer, Cecile, Saada, Matthieu, Salmon, Dominique, Saroufim, Carlo, Schmit, Jean-Luc, Sebire, Manuela, Segonds, Christine, Sivadon-Tardy, Valérie, Soismier, Nathalie, Kerneis, Solen, Son, Olivia, Sunder, Simon, Suy, Florence, Tande, Didier, Tankovic, Jacques, Valin, Nadia, Van Grunderbeeck, Nicolas, Verdon, Renaud, Vergnaud, Michel, Vernet-Garnier, Véronique, Vidal, Magali, Vitrat, Virginie, Vittecoq, Daniel, Vuotto, Fanny, Coordination and statistical analyses, Gorenne, Isabelle, Laouenan, Cédric, Marcault, Estelle, Mentre, France, Pasquet, Blandine, Roy, Carine, Tubiana, S., Varon, E., Biron, C., Ploy, M.-C., Mourvillier, B., Taha, M.-K., Revest, M., Poyart, C., Martin-Blondel, G., Lecuit, M., Cua, E., Pasquet, B., Preau, M., Hoen, B., and Duval, X.

Published
2020
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14. What Place Is There for Long-Acting Antibiotics in the Management of Gram-Positive Infections? A Qualitative Cross-Sectional Study.

Author

Dinh, Aurélien, Béraud, Guillaume, Courjon, Johan, Le Goff, Yann, Ettahar, Nicolas Kader, Grégoire, Matthieu, and Senneville, Eric

Subjects
PROSTHESIS-related infections, SOFT tissue infections, URINARY tract infections, GRAM-positive bacterial infections, JOINT infections
Abstract

Objectives. To identify the current practices with long half-life lipoglycopeptides (LGPs) and potential use/position of oritavancin. Results. Despite their indication being limited to skin and soft tissue infections (SSTIs), long half-life lipoglycopeptides are mainly used off-label to treat bone and joint infections (BJIs) and infective endocarditis. Oritavancin and dalbavancin are both semisynthetic lipoglycopeptide antibiotics with activity against Gram-positive organisms. The game-changing property of these two antibiotics is their one-time dosing. Due to its shorter half-life, oritavancin might have an advantage over dalbavancin for a treatment duration of less than 2 weeks, as it could be used both in prolonged treatments of complicated patients in BJIs or administered as a single-dose treatment for Gram-positive cocci infections usually treated by a 5- to 10-day antibiotic course. These infections include urinary tract infections, bacteremias, catheter-related infections, etc. In addition to the possibility of being used as an end-of-treatment injection, oritavancin could be used as an empiric therapy treatment in the postoperative period in the context of device-associated especially prosthetic joint infections to allow for the early discharge of the patient. Methods. A qualitative survey was conducted in March 2022 including sixteen infectiologists, one internist, five hospital pharmacists, and one pharmacologist. Conclusion. Long half-life lipoglycopeptides contribute to changing the paradigm in the management of acute bacterial infections, as infectiologists now consider a range of indications and patient profiles for one single drug. Oritavancin strengthens the therapeutic arsenal in numerous infections from BJIs to urinary tract infections and could help to manage specific clinical situations, on top of providing potential benefits for the hospital's budget. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Legal framework of antimicrobial stewardship in hospitals (LEASH): a European Society of Clinical Microbiology and Infectious Diseases (ESCMID) cross-sectional international survey

Author

Allerberger, Franz, Benko, Ria, Berild, Dag, Cunney, Robert, Debacker, Martine, Deptula, Aleksander, Dumpis, Uga, Dyar, Oliver J, Ergonul, Onder, Szabo, Balint Gergely, Gormley, Cairine, Grape, Malin, Gudnason, Thorolfur, Howard, Philip, Huttner, Benedikt, Ioannou, Petros, Ionescu, Ramona, Keuleyan, Emma, Knepper, Viviane, Kofteridis, Diamantis, Kostyanev, Tomislav, Krcmery, Vladimir, Lakatos, Botond, Luzzati, Roberto, ten Oever, Jaap, Pagani, Leonardo, Pardo, José Ramón Paño, Popescu, Mihaela, Popovici, Mihaela, Paul, Mical, Bix, Hege Salvesen, Schouten, Jeroen, Sneddon, Jacqueline, Stevanović, Goran, Wechsler-Fördös, Agnes, de With, Katja, Vlahović-Palčevski, Vera, Zarb, Peter, Beović, Bojana, Pulcini, Céline, Dumartin, Catherine, Béraud, Guillaume, Nerat, Barbara, Maurel, Cristina, Doušak, May, and Čižman, Milan

Published
2018
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17. Predominance of healthcare-associated cases among episodes of community-onset bacteraemia due to extended-spectrum β-lactamase-producing Enterobacteriaceae

Author

Aissa, Nejla, Losniewski, Alain, Henard, Sandrine, Rabaud, Christian, Janssen, Cécile, Pagani, Léonardo, Bland, Stéphane, Gaillat, Jacques, Bru, Jean Pierre, Bonnin, Pierre, Clavère, Gaelle, Vitrat, Virginie, Maulin, Laurence, Quarsaet, Luc, Roger, Helene, Euzen, Jean-Baptiste, Denes, Eric, Couve-Daecon, Elodie, Lechiche, Catherine, Lavigne, Jean-Philippe, Mondain, Véronique, Pulcini, Celine, Garnier, Veronique, Lambert, Dorothée, Hentzien, Maxime, Nguyen, Yohan, Talarmin, Jean Paul, Rameau, Pascaline, Geffroy, Françoise, Salmon-Rousseau, Arnaud, Cattoir, Vincent, Froissart, Antoine, Aberrane, Said, Legout, Laurence, Roblot, France, Beraud, Guillaume, Pavese, Patricia, Belmonte, Olivier, Traversier, Nicolas, Bellec, Laurent, Lagrange-Xelot, Marie, Moiton, Marie-Pierre, Kuli, Barbara, Longuet, Pascal, Scanvic, Agnes, Colombain, Lea, Ferreyra, Milagros, Jean, Maxime, Eden, Aurelia, Laurens, Etienne, Saada, Matthieu, Aumaitre, Hugues, Malet, Martine, Roustant, Frederique, LeMoing, Vincent, Helene, Jean-Pierre, Theodore, Jonathan, Garandeau, Caroline, Caillon, Jocelyne, Olivero, Benjamin, Boutoille, David, Lepelletier, Didier, Grandière-Perez, Lucia, Beaudron, Aurélie, Ramanantsoa, Céline, Varache, Catherine, Varache, Nicolas, Crochette, Nicolas, Hitoto, Hikombo, Blanchi, Sophie, Penn, Pascale, Louis, Bernard, Vanjak, Dominique, Escande, Marie-Christine, Patrigeon, René-Gilles, Honoré, Stéphanie, Barrelet, Audrey, Amara, Marlène, Galempoix, Jean-Marc, Réveil, Jean-Claude, Bucchiotty, Patricia, Couzigou, Carine, LeMonnier, Alban, Boidin, Emilie, Sire, Stephane, Luizy, Nelly, Bronstain, Caroline, Harbarth, Stephan, Fankhauser, Carolina, Brossier, Caroline, von Dach, Elodie, Sauve, Colette, Adam, Marie-Noelle, Hocqueloux, Laurent, Bret, Laurent, André, Marie-Hélène, Barruet, Régine, Challier, Marion, Cabié, Andre, Roze, Benoit, Plesiat, Patrick, Jeanot, Katy, Patry, Isabelle, Moreau, Joséphine, Chirouze, Catherine, Laurent, Aaron, Bachelier, Marie-Nadège, Kac, Guillaume, Farthouat, Nicolas, Feuillebois, Nicolas, Guimard, Thomas, Bourdon, Sandra, Nguyen, Sophie, Alfandari, Serge, Bentayeb, Houcine, Albertini, Mari-Thérèse, Marchou, Bruno, Gaudré, Noémie, Dubois, Damien, Guillet-Caruba, Christelle, Doucet Populaire, Florence, Fortineau, Nicolas, Escaut, Leila, Lesprit, Philippe, Fihman, Vincent, Gauzit, Rémy, Raymond, Josette, Kerneis, Solene, Leflon-Guibout, Veronique, Lefort, Agnes, Dinh, Aurelien, Roux, Anne-Laure, Abgrall, Sophie, Jauréguy, Françoise, Lucet, Jean-Christophe, Soismier, Nathalie, Lopes, Amanda, Cambau, Emmanuelle, Manceron, Veronique, Barnaud, Guilène, Zahar, Jean-Ralph, Ruckly, Stephane, Hikombo, Hitoto, Bernard, Louis, Timsit, Jean-François, and Brun-Buisson, Christian

Published
2017
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24. Relationship between serotypes, disease characteristics and 30-day mortality in adults with invasive pneumococcal disease

Author

Benadji, Amine, Danis, Kostas, Brieu, Nathalie, Gaillat, Jacques, Mourvillier, Bruno, Bollaert, Pierre-Edouard, Gaillot, Olivier, Taha, Muhamed-Kheir, Bonacorsi, Stephane, Lecuit, Marc, Frachet, Bruno, Debroucker, Thomas, Levy Bruhl, Daniel, Preau, Marie, Anguel, Nadia, Argaud, Laurent, Arista, Sophie, Armand-Lefevre, Laurence, Balavoine, Stéphanie, Baraduc, Régine, Barnaud, Guilène, Béraud, Guillaume, Bernars, Georges, Bertei, Dominique, Bessede, Emilie, Billard Pomares, Typhaine, Biron, Charlotte, Bland, Stéphane, Boileau, Julien, Boubeau, Patrice, Bourdon, Sandra, Bousquet, Aurore, Boyer, Sophie, Bozorg-Grayeli, Alexis, Bretonniere, Cédric, Bricaire, François, Brocas, Elsa, Brun, Michel, Buret, Jennifer, Burucoa, Christophe, Cabalion, Jean, Cabon, Mathieu, Cambau, Emmanuelle, Camuset, Guillaume, Canevet, Christophe, Caron, François, Carricajo, Anne, Castan, Bernard, Caumes, Eric, Cazanave, Charles, Chabrol, Amélie, Challan-Belval, Thibaut, Chanteperdrix-Marillier, Vanessa, Chaplain, Chantal, Charlier-Woerther, Caroline, Chaussade, Hélène, Chirouze, Catherine, Clair, Bernard, Colot, Julien, Conil, Jean-Marie, Cordel, Hugues, Cormier, Philippe, Cousson, Joël, Cronier, Pierrick, Cua, Eric, Dao-Dubremetz, Anne, Dargere, Sylvie, Degand, Nicolas, Dekeyser, Sophie, Delaune, Deborah, Denes, Eric, Dequin, Pierre-Francois, Descamps, Diane, Descloux, Elodie, Desmaretz, Jean-Luc, Diehl, Jean-Luc, Dimet, Jérôme, Dinh, Aurélien, Duval, Xavier, Escaut, Lelia, Fabe, Claude, Faibis, Frédéric, Flateau, Clara, Fonsale, Nathalie, Fortineau, Nicolas, Gagneux-Brunon, Amandine, Garandeau, Caroline, Garcia, Magali, Garot, Denis, Gaudry, Stéphane, Goehringer, François, Gravet, Alain, Gregoire-Faucher, Valérie, Grosset, Marine, Gueit, Isabelle, Guelon, Dominique, Guimard, Thomas, Hadou, Tahar, Helene, Jean-Pierre, Henard, Sandrine, Henry, Benoit, Hochart, Anne-Cécile, Hoen, Bruno, Illes, Gabriela, Jaffuel, Sylvain, Jarrin, Irène, Jaureguy, Françoise, Joseph, Cédric, Juvin, Marie-Emmanuelle, Kayal, Samer, Kerneis, Solen, Lamaury, Isabelle, Laurens, Etienne, Laurichesse, Henri, Le Brun, Cécile, Le Moing, Vincent, Le Turnier, Paul, Lecuyer, Hervé, Ledru, Sylvie, Legrix, Céline, Lemaignen, Adrien, Lemble, Chantal, Lemee, Ludovic, Lesens, Olivier, Lhommet, Claire, Males, Silvija, Malpote, Edith, Martin-Blondel, Guillaume, Marx, Matthieu, Masson, Raphael, Matray, Olivier, Mbadi, Aurore, Mechai, Frédéric, Mellon, Guillaume, Merens, Audrey, Meyohas, Marie Caroline, Michon, Adrien, Mootien Yoganaden, Joy, Morquin, David, Mouly, Stéphane, Mrozek, Natacha, Nguyen, Sophie, Oziol, Eric, Page, Bernard, Patrat-Delon, Solène, Patry, Isabelle, Picot, Sandrine, Pierrejean, Denys, Piroth, Lionel, Plassart, Claire, Plessis, Patrice, Ploy, Marie-Cécile, Portel, Laurent, Poubeau, Patrice, Poupard, Marie, Poyart, Claire, Prazuck, Thierry, Quaesaet, Luc, Raffi, François, Ramanantsoa, Adriatsiferana, Rapp, Christophe, Raskine, Laurent, Raymond, Josette, Revest, Matthieu, Riche, Agnès, Robaday-Voisin, Stéphanie, Robin, Frédéric, Romaszko, Jean-Pierre, Rousseau, Florence, Roux, Anne-Laure, Royer, Cécile, Saada, Matthieu, Salmon, Dominique, Saroufim, Carlo, Schmit, Jean Luc, Sebire, Manuela, Segonds, Christine, Sivadon-Tardy, Valérie, Soismier, Nathalie, Son, Olivia, Sunder, Simon, Suy, Florence, Tande, Didier, Tankovic, Jacques, Valin, Nadia, van Grunderbeeck, Nicolas, Vandenesch, François, Varon, Emmanuelle, Verdon, Renaud, Vergnaud, Michel, Vidal, Magali, Vittecoq, Daniel, Vuotto, Fanny, Gorenne, Isabelle, Laouenan, Cédric, Marcault, Estelle, Mentre, France, Pasquet, Blandine, Roy, Carine, Tubiana, Sarah, Arsac, Philippe, Benoit, Martha, Bernard, Louis, Bissuel, François, Bret, Laurent, Brieu, Natalie, Burret, Jennifer, Carvalhoschneider, Claudia, Champagne, Hélène, Chapalain, Joséphine, Chardon, Hubert, Chavanet, Pascal, Ducruet, Judith, Epaulard, Olivier, Fabre, Marc, Fasquelle, Dominique, Forestier, Emmanuel, Galempoix, Jean-Marc, Gautier, Guillaume, de Curraize, Claire Goulard, Gracet, Alain, Gubavu, Camélia, Guinard, Jérôme, Habet, Tarik, Haudour, Aurélie, Henry, Caroline, Hombrouckalet, Cécile, Janssen, Céline, Kisteman, Jean-Paul, Lanotte, Philippe, Lartigue, Marie-Frédérique, Launois, Claire, Lebrun, Cécile, Legout, Laurence, Levast, Marion, Madoux, Yannick, Maulin, Laurence, Mestrallet, Stéphanie, Mohareb, Abdo, Mootien, Joy, Nguyen, Yohan, Noel, Franck, Ogielska, Maja, Ogier Desserrey, Agathe, Paleau, Anne, Pavel, Simona, Pechinot, André, Pelloux, Isabelle, Petillon, Camille, Petitprez, Hélène, Podac, Bianca, Poirot, Jerome, Ponceau, Bénédicte, Prieur, Nathalie, Recule, Christine, Saraceni, Orlando, Sartre, Jacques, Sifaoui, Farid, Simonin, Catherine, Strady, Christophe, Tellini, Charlotte, Texier, Anthony, Thouvenin, Maxime, Tixier, Anne, Tremeaux, Pauline, Verger, Pascale, Vernet-Garnier, Véronique, Verquin, Jean-Pierre, Vitrat, Virginie, Vray, Isabelle, Zamfir, Oana, Zucchini, Laure, Centre d'investigation Clinique [CHU Bichat] - Épidémiologie clinique (CIC 1425), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Chrono-environnement (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques (RESINFIT), CHU Limoges-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), ARN régulateurs bactériens et médecine (BRM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), CHU Pontchaillou [Rennes], CHI Créteil, Pathologies Pulmonaires et Plasticité Cellulaire - UMR-S 1250 (P3CELL), Université de Reims Champagne-Ardenne (URCA)-Institut National de la Santé et de la Recherche Médicale (INSERM), The COMBAT study was supported by the Assistance Publique Hopitaux de Paris, French Ministry of Health, Inserm, SPILF, and the Pfizer Pharmaceutical company, which also funded ORP. The study was endorsed by the following professional organizations: Association Pour l’enseignement de la Thérapeutique, Société de Pathologie Infectieuse de Langue Française, Société Française de Microbiologie, Société Nationale Française de Médecine Interne, Société de Réanimation de Langue Française, Société Française de Gérontologie, Société Française d’Anesthésie-Réanimation. The SIIP study was supported by (i) the Société de Pathologie Infectieuse de Langue Fran.aise (SPILF, the French Infectious Diseases Society), (ii) Santé Publique France (SpFrance, the French National Public Health Agency), (iii) the European Centre for Disease Prevention and Control (ECDC), and (iv) Pfizer. The Regional Observatories of Pneumococci (Observatoires Régionaux du Pneumocoque) were supported by Pfizer, BioMerieux, and Sanofi., and Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE)

Subjects
Adult, Microbiology (medical), Serotype, medicine.medical_specialty, Multivariate analysis, Adolescent, [SDV]Life Sciences [q-bio], 30-day mortality, Serogroup, medicine.disease_cause, Logistic regression, Pneumococcal Infections, Cohort Studies, Pneumococcal Vaccines, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Streptococcus pneumoniae, medicine, Humans, 030212 general & internal medicine, ComputingMilieux_MISCELLANEOUS, Aged, 0303 health sciences, Meningitis, Pneumococcal, 030306 microbiology, business.industry, Mortality rate, Infant, Invasive pneumococcal disease, Pneumococcal vaccine, General Medicine, bacterial infections and mycoses, medicine.disease, 3. Good health, Infectious Diseases, business, Meningitis, Cohort study
Abstract

International audience; Purpose: Invasive pneumococcal disease (IPD) is responsible for substantial mortality and morbidity worldwide. We aimed to identify host and bacterial factors associated with 30-day mortality in 18-year-old patients hospitalized with IPD in France from 2013 to 2015.Methods: This study analyzed data collected from consecutives IPD cases included in two parallel multi-center cohort studies: COMBAT study (280 patients with pneumococcal community-acquired bacterial meningitis) and SIIP study (491 patients with non-meningitis IPD). Factors associated with 30-day mortality were identified using logistic regression.Results: Among the 771 enrolled patients (median age 66 years, IQR [52.0-79.7]), 592/767 (77.2%) had at least one chronic disease. Patients with meningitis were younger (60.2 vs 70.9 years; p < 0.001) and had fewer chronic diseases than those with non-meningitis IPD (73.3% vs 79.4%; p = 0.05). Non-vaccine serotypes were more frequent in meningitis patients than in those with other IPD (36.1% vs 23.1%; p < 0.001). The overall 30-day mortality was 16.7% and patients with concurrent meningitis and extra-cerebral IPD had the highest 30-day mortality rate (26.5%). On multivariate analyses, older age, history of malignant solid tumor, meningeal IPD and serotypes previously identified with high mortality potential were independently associated with 30-day mortality. Of the serotypes with high mortality potential, 80% were included in licensed (PCV13 or PPV23) vaccines.Conclusion: We observed an effect of both host factors and pneumococcal serotypes on 30-day mortality in IPD. This highlights the need for a focused strategy to vaccinate at-risk patients.Clinical trial: ClinicalTrial. Gov identification number: NCT01730690.

Published
2021
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30. Contributors

Author

Akova, Murat, primary, Altiner, Attila, additional, Andrašević, Arjana T., additional, Azap, Ozlem K., additional, Bavestrello, Luis, additional, Beović, Bojana, additional, Böhmer, Femke, additional, Béraud, Guillaume, additional, Buising, Kirsty, additional, Can, Füsun, additional, Castro, José L., additional, Čižman, Milan, additional, Cosgrove, Sara E., additional, Cotta, Menino O., additional, de Kraker, Marlieke E.A., additional, de With, Katja, additional, De Waele, Jan, additional, Dyar, Oliver J., additional, Ergönül, Önder, additional, Erntell, Mats, additional, Ghafur, Abdul, additional, Gyssens, Inge C., additional, Harbarth, Stephan, additional, Hedin, Katarina, additional, Hernández-Gómez, Cristhian, additional, Howard, Philip, additional, Hulscher, Marlies E.J.L., additional, Karatuna, Onur, additional, Kern, Winfried V., additional, Keuleyan, Emma, additional, Kofteridis, Diamantis P., additional, Kostyanev, Tomislav, additional, Lacor, Patrick, additional, Levy-Hara, Gabriel, additional, Li, David X., additional, Markou, Theodore I., additional, Mendelson, Marc, additional, Messiaen, Peter, additional, Nathwani, Dilip, additional, Pagani, Leonardo, additional, Paño Pardo, José R., additional, Pluss-Suard, Catherine, additional, Prins, Jan, additional, Pulcini, Céline, additional, Ramón-Pardo, Pilar, additional, Roberts, Jason A., additional, Rodríguez-Baño, Jesús, additional, Schouten, Jeroen, additional, Schwaber, Mitchell J., additional, Senn, Laurence, additional, Shibayama, Keigo, additional, Sinnollareddy, Mahipal G., additional, Sneddon, Jacqueline, additional, Lundborg, Cecilia Stålsby, additional, Tacconelli, Evelina, additional, Thursky, Karin, additional, Valachis, Antonis, additional, Viale, Pierluigi, additional, Villegas, María V., additional, Vlahović-Palčevski, Vera, additional, Wechsler-Fördös, Agnes, additional, Wollny, Anja, additional, and Zanetti, Giorgio, additional

Published
2017
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32. Additional file 1 of Time trends in social contacts before and during the COVID-19 pandemic: the CONNECT study

Author

Drolet, Mélanie, Godbout, Aurélie, Mondor, Myrto, Béraud, Guillaume, Drolet-Roy, Léa, Lemieux-Mellouki, Philippe, Bureau, Alexandre, Demers, Éric, Boily, Marie-Claude, Sauvageau, Chantal, De Serres, Gaston, Hens, Niel, Beutels, Philippe, Dervaux, Benoit, and Brisson, Marc

Abstract

Additional file 1: Table S1. Overview of the different phases of CONNECT. Table S2. Weighting procedure. Table S3. Time trends in the number of social contacts, by location of contacts A mean number of contacts, B median number of contacts. Table S4. Association between the mean number of social contacts and the stringency index. Table S5. Time trends in the total number of social contacts by key socio-demographic characteristics. Table S6. Time trends in the number of social contacts at school/daycare among children-students according to school level. Table S7. Time trends in social contacts at work among workers and according to the type of employment (2016 National occupation classification). Table S8. Time trends in the proportion of workers who reported working remotely, according to the type of employment (2016 National occupation classification). Fig. S1. Example of the social contact diary. Fig. S2. Quebec COVID-19 epidemiology, related physical distancing measures, and CONNECT data periods. Fig. S3. Flowchart of participant identification for CONNECT 1, CONNECT 2, and CONNECT 3,4,5. Fig. S4. Mean number of social contacts according to the intensity of public health measures in Quebec as summarized by the stringency index.

Published
2022
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35. Lockdown impact on age-specific contact patterns and behaviours, France, April 2020

Author

Bosetti, Paolo, primary, Huynh, Bich-Tram, additional, Abdou, Armiya Youssouf, additional, Sanchez, Marie, additional, Eisenhauer, Catherine, additional, Courtejoie, Noémie, additional, Accardo, Jérôme, additional, Salje, Henrik, additional, Guillemot, Didier, additional, Moslonka-Lefebvre, Mathieu, additional, Boëlle, Pierre-Yves, additional, Béraud, Guillaume, additional, Cauchemez, Simon, additional, and Opatowski, Lulla, additional

Published
2021
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36. Multicolumn spinal cord stimulation for significant low back pain in failed back surgery syndrome: a national, multicenter, randomized, controlled health economics study (ESTIMET): 9 June – 089.

Author

Rigoard, Philippe, ROULAUD, Manuel, Monlezun, Olivier, Durand-Zaleski, Isabelle, Ingrand, Pierre, Serrie, Alain, Diallo, Bakari, Peruzzi, Philippe, Hieu, Phong Dam, Voirin, Jimmy, Raoul, Sylvie, Page, Philippe, Fontaine, Denys, Lantéri-Minet, Michel, Blond, Serge, Buisset, Nadia, Cuny, Emmanuel, Cadenne, Myriam, Caire, François, Ranoux, Danièle, Mertens, Patrick, Naous, Hussein, Simon, Emile, Emery, Emelyne, Gadan, Bernardo, Régis, Jean, Sol, Jean-Christophe, Béraud, Guillaume, Debiais, Françoise, Durand, Géraldine, Guétarni, Farid, Delmotte, Alexandre, and Bataille, Benoit

Published
2015

38. Time trends in social contacts before and during the COVID-19 pandemic: the CONNECT study

Author

Drolet, Mélanie, primary, Godbout, Aurélie, additional, Mondor, Myrto, additional, Béraud, Guillaume, additional, Drolet-Roy, Léa, additional, Lemieux-Mellouki, Philippe, additional, Bureau, Alexandre, additional, Demers, Éric, additional, Boily, Marie-Claude, additional, Sauvageau, Chantal, additional, De Serres, Gaston, additional, Hens, Niel, additional, Beutels, Philippe, additional, Dervaux, Benoit, additional, and Brisson, Marc, additional

Published
2021
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40. Systematic Review and Meta-Analysis of Sex Differences in Social Contact Patterns and Implications for Tuberculosis Transmission and Control

Author

Horton, Katherine C, Hoey, Anne L, Béraud, Guillaume, Corbett, Elizabeth L, and White, Richard G

Abstract

Social contact patterns might contribute to excess burden of tuberculosis in men. We conducted a study of social contact surveys to evaluate contact patterns relevant to tuberculosis transmission. Available data describe 21 surveys in 17 countries and show profound differences in sex-based and age-based patterns of contact. Adults reported more adult contacts than children. Children preferentially mixed with women in all surveys (median sex assortativity 58%, interquartile range [IQR] 57%-59% for boys, 61% [IQR 60%-63%] for girls). Men and women reported sex-assortative mixing in 80% and 95% of surveys (median sex assortativity 56% [IQR 54%-58%] for men, 59% [IQR 57%-63%] for women). Sex-specific patterns of contact with adults were similar at home and outside the home for children; adults reported greater sex assortativity outside the home in most surveys. Sex assortativity in adult contacts likely contributes to sex disparities in adult tuberculosis burden by amplifying incidence among men.

Published
2020

42. Lockdown impact on age-specific contact patterns and behaviours in France

Author

Bosetti, Paolo, primary, Huynh, Bich-Tram, additional, Abdou, Armiya Youssouf, additional, Sanchez, Marie, additional, Eisenhauer, Catherine, additional, Courtejoie, Noémie, additional, Accardo, Jérôme, additional, Salje, Henrik, additional, Guillemot, Didier, additional, Moslonka-Lefebvre, Mathieu, additional, Boëlle, Pierre-Yves, additional, Béraud, Guillaume, additional, Cauchemez, Simon, additional, and Opatowski, Lulla, additional

Published
2020
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43. Young doctors’ perspectives on antibiotic use and resistance: a multinational and inter-specialty cross-sectional European Society of Clinical Microbiology and Infectious Diseases (ESCMID) survey

Author

Beović, Bojana, primary, Doušak, May, additional, Pulcini, Céline, additional, Béraud, Guillaume, additional, Paño Pardo, Jose Ramon, additional, Sánchez-Fabra, David, additional, Kofteridis, Diamantis, additional, Cortez, Joana, additional, Pagani, Leonardo, additional, Klešnik, Maša, additional, Nadrah, Kristina, additional, Hafner Fink, Mitja, additional, Nathwani, Dilip, additional, and Uhan, Samo, additional

Published
2019
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46. Legal framework of antimicrobial stewardship in hospitals (LEASH): a European Society of Clinical Microbiology and Infectious Diseases (ESCMID) cross-sectional international survey

Author

Beović, Bojana, primary, Pulcini, Céline, additional, Dumartin, Catherine, additional, Béraud, Guillaume, additional, Nerat, Barbara, additional, Maurel, Cristina, additional, Doušak, May, additional, Čižman, Milan, additional, Allerberger, Franz, additional, Benko, Ria, additional, Berild, Dag, additional, Cunney, Robert, additional, Debacker, Martine, additional, Deptula, Aleksander, additional, Dumpis, Uga, additional, Dyar, Oliver J, additional, Ergonul, Onder, additional, Szabo, Balint Gergely, additional, Gormley, Cairine, additional, Grape, Malin, additional, Gudnason, Thorolfur, additional, Howard, Philip, additional, Huttner, Benedikt, additional, Ioannou, Petros, additional, Ionescu, Ramona, additional, Keuleyan, Emma, additional, Knepper, Viviane, additional, Kofteridis, Diamantis, additional, Kostyanev, Tomislav, additional, Krcmery, Vladimir, additional, Lakatos, Botond, additional, Luzzati, Roberto, additional, ten Oever, Jaap, additional, Pagani, Leonardo, additional, Pardo, José Ramón Paño, additional, Popescu, Mihaela, additional, Popovici, Mihaela, additional, Paul, Mical, additional, Bix, Hege Salvesen, additional, Schouten, Jeroen, additional, Sneddon, Jacqueline, additional, Stevanović, Goran, additional, Wechsler-Fördös, Agnes, additional, de With, Katja, additional, Vlahović-Palčevski, Vera, additional, and Zarb, Peter, additional

Published
2018
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50. Nebulized Liposomal Amphotericin B for Treatment of Pulmonary Infection Caused by Hormographiella aspergillata: Case Report and Literature Review

Author

Godet, France, Cateau, France, Rammaert, France, Grosset, France, Le Moal, France, Béraud, France, Martellosio, France, Iriart, France, Cadranel, France, Roblot, France, Godet, Cendrine, Cateau, Estelle, Rammaert, Blandine, Grosset, Marine, Le Moal, Gwenaël, Béraud, Guillaume, Martellosio, Jean Philippe, Iriart, Xavier, Cadranel, Jacques, Médecine Interne et Maladies Infectieuses, CHU de Poitiers, Poitiers, France, Centre hospitalier universitaire de Poitiers (CHU Poitiers), Université de Poitiers - Faculté de Médecine et de Pharmacie, Université de Poitiers, Laboratoire de Parasitologie-Mycologie (CHU de Poitiers), Pharmacologie des anti-infectieux (PHAR), Université de Poitiers-Institut National de la Santé et de la Recherche Médicale (INSERM), Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Hasselt University (UHasselt), CHU Toulouse [Toulouse], Centre de Physiopathologie Toulouse Purpan (CPTP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de Pneumologie - Oncologie Thoracique - Maladies Pulmonaires Rares [CHU Tenon], CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Sorbonne Université (SU), Univ Hosp Poitiers, Dept Infect Dis, Service des Maladies Infectieuses, Centre hospitalier universitaire de Poitiers (CHU Poitiers)-Hôpital de La Milétrie, Microbiologie de l'Eau (MDE), Ecologie et biologie des interactions (EBI), Université de Poitiers-Centre National de la Recherche Scientifique (CNRS)-Université de Poitiers-Centre National de la Recherche Scientifique (CNRS), Université de Poitiers-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP), CMES, Laboratoire Microorganismes : Génome et Environnement (LMGE), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Centre National de la Recherche Scientifique (CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Centre National de la Recherche Scientifique (CNRS), Santé publique : épidémiologie et qualité des soins-EA 2694 (CERIM), Centre de Physiopathologie Toulouse Purpan ex IFR 30 et IFR 150 (CPTP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Theranoscan, Université Pierre et Marie Curie - Paris 6 (UPMC), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
0301 basic medicine, Adult, Male, medicine.medical_specialty, Antifungal Agents, Veterinary (miscellaneous), medicine.medical_treatment, [SDV]Life Sciences [q-bio], 030106 microbiology, Hormographiella aspergillata, Hematopoietic stem cell transplantation, Applied Microbiology and Biotechnology, Microbiology, 03 medical and health sciences, 0302 clinical medicine, Medical microbiology, Refractory, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Amphotericin B, Administration, Inhalation, Medicine, Humans, Transplantation, Homologous, 030212 general & internal medicine, Lung, Aerosols, Lung Diseases, Fungal, business.industry, Mortality rate, Standard treatment, Hematopoietic Stem Cell Transplantation, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, 3. Good health, medicine.anatomical_structure, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Treatment Outcome, Anesthesia, Administration, Intravenous, Nebulized liposomal amphotericin B, business, Complication, Agaricales, Agronomy and Crop Science
Abstract

International audience; Invasive fungal infection is a serious complication following allogeneic hematopoietic stem cell transplantation. Pulmonary infection due to Hormographiella aspergillata is an uncommon condition associated with a high mortality rate. The susceptibility of H. aspergillata to available antifungal agents is not well established. We report for the first time a case of H. aspergillata lung infection that responded poorly to conventional treatment with liposomal amphotericin B (LAmB; 3 mg kg-1 of body weight per day) with renal damage at higher posology (5 mg kg-1 of body weight per day), but improved rapidly after addition of nebulized LAmB to intravenous LAmB (3 mg kg-1 of body weight per day). Successful treatment of our patient using nebulized LAmB would be worth evaluating in cases refractory to standard treatment or when the reference treatment may not be extended due to interaction or side effects.

Published
2016
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