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BackgroundThe duration of immune response to COVID-19 vaccination is of major interest. Our aim was to analyze the determinants of anti-SARS-CoV-2 IgG titer at 6 months after 2-dose vaccination in an international cohort of vaccinated healthcare workers (HCWs).MethodsWe analyzed data on levels of anti-SARS-CoV-2 Spike antibodies and sociodemographic and clinical characteristics of 6,327 vaccinated HCWs from 8 centers from Germany, Italy, Romania and Slovakia. Time between 1st dose and serology ranged 150-210 days. Serological levels were log-transformed to account for the skewness of the distribution and normalized by dividing them by center-specific standard errors, obtaining standardized values. We fitted center-specific multivariate regression models to estimate the cohort-specific relative risks (RR) of an increase of 1 standard deviation of log antibody level and corresponding 95% confidence interval (CI), and finally combined them in random-effects meta-analyses.ResultsA 6-month serological response was detected in 99.6% of HCWs. Female sex (RR 1.10, 95%CI 1.00-1.21), past infection (RR 2.26, 95%CI 1.73-2.95) and two vaccine doses (RR 1.50, 95%CI 1.22-1.84) predicted higher IgG titer, contrary to interval since last dose (RR for 10-day increase 0.94, 95%CI 0.91-0.97) and age (RR for 10-year increase 0.87, 95%CI 0.83-0.92). M-RNA-based vaccines (pConclusionsFemale gender, young age, past infection, two vaccine doses, and m-RNA and heterologous vaccination predicted higher antibody level at 6 months. These results corroborate previous findings and offer valuable data for comparison with trends observed with longer follow-ups.

RESUMÉ The purpose of my thesis is to analyze the position of women in Roman law. The thesis is composed of seven chapters, each of them dealing with different aspects of life of women in ancient Rome. First, it shortly describes sociological reasons of the legal differences between men and women and in chapter two its major consequences. Chapter Three describes the position of woman in her family, mainly patria potestas, which played, along with the marriage, the most important role in woman's life. Part two, concerning marriage, first describes the marriage itself and then its ending, divorce or widowhood and also mentions remarriage. Last part of this chapter looks at problems concerning relations between men and women outside marriage, concubinage, prostitution and the final subpart deals with the problem of sexual offences. Chapter four is subdivided into three parts focused on the property of women. First part illustrates main issues concerning the dowry. Then second part, property of married couple, analyze in its subchapters making gifts between husband and wife and finally, the liability on obligations. The third part describes the guardianship of women, tutela mulierum. Chapter five provides an outline of legacies. First part is about problems arising from testamentary succession. This part...