8 results on '"Büttner, Juliane"'
Search Results
2. Side effects of phytotherapeutics in cancer care - consistencies and inconsistencies in national and international databases
- Author
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Büttner, Juliane, primary, Büntzel, Judith, additional, Büntzel, Jens, additional, and Hübner, Jutta, additional
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- 2023
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- View/download PDF
3. Follow-Up Comparison of Fluorescence Optical Imaging With Musculoskeletal Ultrasound for Early Detection of Psoriatic Arthritis
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Büttner, Juliane, Glimm, Anne-Marie, Kokolakis, Georgios, Erdmann-Keding, Magdalena, Burmester, Gerd-Rüdiger, Hoff, Paula, Klotsche, Jens, and Ohrndorf, Sarah
- Subjects
psoriatic arthritis ,ultrasound imaging ,follow-up studies (MeSH) ,inflammation ,hand ,fluorescence optical imaging ,600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit - Abstract
Objectives: Early diagnosis of psoriatic arthritis (PsA) is crucial for a patient outcome but hampered by heterogenous manifestation and a lack of specific biomarkers. We recently showed that fluorescence optical imaging (FOI) can differentiate between patients with confirmed and suspected PsA. This study aims to follow-up (FU) patients with confirmed and suspected PsA focusing on patients with a change from suspected to confirmed PsA by the use of FOI in comparison with musculoskeletal ultrasound (MSUS). Methods: Follow-up examination of patients included in the study performed by Erdmann-Keding et al. in which FOI of both hands was performed in a standardized manner using three predefined phases (p1–p3) and PrimaVista Mode (PVM). The comparison was drawn to grayscale–power Doppler (GS/PD) MSUS of the clinically dominant hand (wrist, MCP, PIP, DIP 2–5) from dorsal or palmar. Results: Patients with a change from suspected to diagnosed PsA showed an increased prevalence of joints with pathological enhancement in FOI (p = 0.046) with an unchanged joint distribution pattern, especially with a dominant involvement of DIP joints. Compared to the baseline, these patients were three times more common to show enhancement in FOI p3 at FU. Newly detected pathologic joints by FOI (PVM, p2) and MSUS at FU were positively associated with the change of diagnosis from suspected to confirmed PsA (FOI: AUC 0.78; GSUS: AUC 0.77). Conclusion: Fluorescence optical imaging appears to be a helpful tool to detect early PsA and to distinguish between acute and chronic disease stages. It could thereby become a suitable tool as a screening method to select psoriasis patients with an indication for further rheumatological evaluation.
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- 2022
4. Follow-Up Comparison of Fluorescence Optical Imaging With Musculoskeletal Ultrasound for Early Detection of Psoriatic Arthritis
- Author
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Büttner, Juliane, primary, Glimm, Anne-Marie, additional, Kokolakis, Georgios, additional, Erdmann-Keding, Magdalena, additional, Burmester, Gerd-Rüdiger, additional, Hoff, Paula, additional, Klotsche, Jens, additional, and Ohrndorf, Sarah, additional
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- 2022
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- View/download PDF
5. Influence of mucinous and necrotic tissue in colorectal cancer samples on KRAS mutation analysis
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Büttner, Juliane, primary, Lehmann, Annika, additional, Klauschen, Frederick, additional, Hummel, Michael, additional, Lenze, Dido, additional, Dietel, Manfred, additional, and Jöhrens, Korinna, additional
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- 2017
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6. Permeability of young sea ice from microtomographic images
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Büttner, Juliane
- Subjects
Permability ,Sea ice ,Astrophysics::Earth and Planetary Astrophysics ,Microstructure ,Porosity ,Mathematics and natural science: 400::Geosciences: 450::Oceanography: 452 [VDP] ,Physics::Geophysics - Abstract
The author has since publication changed name to: Juliane Borge. The permeability of sea ice controls the transport of substances through the ice and thereby its surface properties as well as the exchange of heat, salt and gas between ice, ocean and atmosphere. More observations and understanding are necessary to properly implement the impact of permeability on sea ice melt and growth in models. This study employs and evaluates a microscopical approach to determine permeability. We combine structure-preserving field sampling with non-destructive synchrotron-based microtomography (SXRT) and lattice Boltzmann modelling (LBM) of fluid flow. Samples of young sea ice from Kongsfjorden, Svalbard, were centrifuged at their respective in situ temperatures before SXRT was performed at temperatures below -40°C, resulting in 3-dimensional images 1.2x1.2x1.7cm3 in size with a resolution of 11.84 μm. From these images microstructural characteristics of sea ice were derived and fluid flow through the samples was modelled with LBM at 22 and 35 μm resolution to obtain directional values of permeability for all three directions. Our method is limited to small sample sizes due to constraints with respect to computer memory and imaging. Therefore it might not be appropriate for all types of ice. With increasing computer memory and parallelization the applicability of this method will increase. Its major advantage over conventional permeability measurements is that it produces a 3-dimensional representation of the pore space which allows for the derivation of microstructural quantities and for modelling processes such as fluid flow or radiative transfer. Quantities derived from the microstructure were different porosities, a critical length scale, minor and major ellipse axis lengths, pore volume to surface ratio, two-point correlation length, pore radius and area distributions as well as measures of hydraulic and electrical tortuosity. Their intercorrelations and porosity dependence varied with ice type. Our data suggested a percolation transition at a porosity of about 7% for columnar ice both vertically and horizontally parallel to the plates. Permeability of columnar ice exhibited a horizontal anisotropy of 0.21 between flow parallel and perpendicular to the columns. No difference was found between horizontal flow parallel to the plates and vertical flow. This finding is relevant for field techniques of measuring sea ice permeability that strongly depend on the anisotropy factor. Furthermore, correlations between the permeability of columnar ice and porosities as well as several length scales indicated a strong dependence on effective porosity (the connected pore space) and the length scales describing pore necks and the smallest dimension of the pores. Power law regressions on porosities and length scales predicted permeability more accurately than common models derived from studies of sandstone permeability. Havisens permeabilitet kontrollerer transporten av stoffer gjennom isen og dermed dens overflateegenskaper samt utveksling av varme, salt og gass mellom is, hav og atmosfære. Flere observasjoner og mer kunnskap er nødvendig for å integrere permeabilitetens effekt på isvekst og smelting i modeller. Denne studien anvender og evaluerer en mikroskopisk tilnærming for å bestemme permeabilitet av havis. Vi kombinerer strukturbevarende prøvetaking med ikke-destruktiv synkrotron-basert røntgenmikrotomografi (SXRT) og gitter Boltzmann modellering (LBM) av væskestrømning. Prøver av ung havis fra Kongsfjorden, Svalbard, ble sentrifugert ved sine in situ temperaturer før SXRT ble gjennomført ved temperaturer under -40°C, resulterende i 1.2x1.2x1.7cm3 store 3D bilder med en oppløsning på 11.84μm. Disse bildene ble brukt til å finne mikrostrukturkarakteristikker og modellere væskestrømning gjennom prøvene med LBM på 22 og 35μmm oppløsning for å beregne permeabiliteter i alle tre retninger. Metoden vår er begrenset til små prøvestørrelser på grunn av begrensninger i dataminne og bildeteknikk og er derfor ikke like velegnet for alle istyper. Med økende dataminne og parallelisering vil bruksområdet til denne metoden vokse. Dens største fordel overfor konvesjonelle permeablitetsmålinger er at den produserer en 3D representasjon av porerommet i isen som tillater beregning av mikrostrukturmål og modellering av for eksempel væskestrøming eller strålingsoverføring. Størrelser beregnet utifra miktrostrukturen var forskjellige porøsiteter, en kritisk lengdeskala, store og små akselengder av ellipser, forhold mellom porevolum og -overflate, to-punktskorrelasjonslengde, poreradius- og arealfordelinger så vel som mål av både hydraulisk og elektrisk tortuositet. Interkorrelasjonene og porøsitetsavhengigheten varierte med istype. Våre data foreslår en perkolasjonsovergang ved ca. 7 % porøsitet for søyle-is (columnar) parallel til lagene. Permeabilitetene av søyle-is oppviste en horisontal anisotropi på 0.21 mellom strømning parallel og loddrett på lagene. Ingen anisotropi ble funnet mellom horisontal strømning parallel til lagene og vertikal strømning. Dette resultatet er relevant for feltmålinger av havispermeabilitet som er avhengige av anisotropifaktoren. Dessuten tyder undersøkelsen av korrelasjonen av permeabiliteten for søyle-is med porositetene og lengdeskalaene på en sterk avhengighet av effektiv porøsitet (forbundet porerom) og de lengdeskalaene som beskriver porehals og den korteste dimensjonen av porene. Regresjoner med potensfunksjoner av permeabilitet med porøsiteter og lengdeskalaer forutsa permeabiliteten bedre enn vanlige modeller fra studier av sandsteinpermeabiliteter. GEOF399
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- 2011
7. Ion fractionation in young sea ice from Kongsfjorden, Svalbard
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Maus, Sönke, primary, Müller, Susann, additional, Büttner, Juliane, additional, Brütsch, Sabina, additional, Huthwelker, Thomas, additional, Schwikowski, Margit, additional, Enzmann, Frieder, additional, and Vähätolo, Anssi, additional
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- 2011
- Full Text
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8. Influence of mucinous and necrotic tissue in colorectal cancer samples on KRAS mutation analysis.
- Author
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Büttner J, Lehmann A, Klauschen F, Hummel M, Lenze D, Dietel M, and Jöhrens K
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- Adenocarcinoma, Mucinous genetics, Colorectal Neoplasms genetics, DNA Mutational Analysis, Humans, Mutation, Necrosis genetics, Necrosis pathology, Retrospective Studies, Adenocarcinoma, Mucinous pathology, Colorectal Neoplasms pathology, Proto-Oncogene Proteins p21(ras) genetics
- Abstract
Evaluation of the RAS mutation status is necessary for patients with advanced colorectal cancer to predict the response to anti-EGFR therapy. In routine diagnostics, FFPE tissue samples are tested by sequencing (amplicon-based NGS and Sanger) to obtain the RAS status of the patient. Samples that are collected after chemotherapy occasionally contain necrotic tissue. Furthermore, colorectal cancer tissue sometimes has mucinous components. This may pose a challenge to molecular analysis because mucinous tumor samples often contain only few tumor cells compared to solid tumor samples. Therefore, the aim of this study was to explore if mucin or necrosis affect mutation analysis and if mucinous tumor samples contain enough tumor cells for reliable mutation detection. To this end, we analyzed KRAS status in 10 samples showing mucin production and 10 samples with necrosis. In all 20 samples the tissue areas with the highest amount of mucin or necrosis were used for re-evaluation. These results show no differences with those obtained during routine diagnostics, where analysis of mucinous or necrotic areas was tried to avoid. Our study thus shows that mucin and necrosis have no influence on KRAS mutation analysis. Furthermore we were able to demonstrate that mucinous adenocarcinoma contains enough tumor cells for a valid mutation analysis. In addition, we also observed only minor differences in KRAS status results when comparing Sanger sequencing with NGS. Both methods detected the KRAS mutation in 19 of 20 tested samples, even for mutated samples with low allele-frequencies., (Copyright © 2017 Elsevier GmbH. All rights reserved.)
- Published
- 2017
- Full Text
- View/download PDF
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