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1,241 results on '"BAEK, KWANG‐HYUN"'

11. Padina boergesenii mediated synthesis of Se-ZnO bimetallic nanoparticles for effective anticancer activity

Author

Balaji Thirupathi, Yimtar Lanutoshi Pongen, Govindarajan Rasiravathanahalli Kaveriyappan, Pavan Kumar Dara, Suresh Rathinasamy, Saranya Vinayagam, Thanigaivel Sundaram, Baek Kwang Hyun, Thirumurugan Durairaj, and Suresh Kumar Rajamani Sekar

Subjects
Padina boergesenii, green synthesis, Se-ZnO nanoparticles, anticancer, hepatoblastoma cell lines, MCF7 breast cancer cell line, Microbiology, QR1-502
Abstract

IntroductionEvaluating the anticancer property of Padina boergesenii mediated bimetallic nanoparticles.MethodsThe present study focuses on synthesizing Se-ZnO bimetallic nanoparticles from an aqueous algal extract of brown algae Padina boergesenii.Synthesized Se-ZnO NPs were characterized by UV, FTIR, SEM-EDS and HRTEM for confirmation along with the anticancer activity by MTT assay.ResultsThe UV gave an absorbance peak at 342 and 370 nm, and the FTIR showed functional groups involved in synthesizing Se-ZnO NPs. The TEM micrographs indicated the crystalline nature and confirmed the size of the Se-ZnO NPs to be at an average size of 26.14 nm. Anticancer efficacy against the MCF-7 breast and HepG2 (hepatoblastoma) cell lines were also demonstrated, attaining an IC50 value of 67.9 µg and 74.9 µg/ml respectively, which caused 50% cell death.DiscussionThis work aims to highlight an effective method for delivering bioactive compounds extracted from brown algae and emphasize its future therapeutic prospects. The potential of Selenium-Zinc oxide nanoparticles is of great interest due to the biocompatibility and low toxicity aspects of selenium combined with the cost-effectiveness and sustainability of zinc metal. The presence of bioactive compounds contributed to the stability of the nanoparticles and acted as capping properties.

Published
2024
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33. An Inductance-Variation-Insensitive Buck Converter Using a Dynamic Ramp Compensation With Slope Sensing Technique

Author

Shin, Dong-Hyun, Jang, Chunghee, Kim, Youngkyu, Kim, Tony Tae-Hyoung, Lee, Sukho, and Baek, Kwang-Hyun

Abstract

This brief introduces a current-mode DC-DC buck converter that operates without performance degradations, even when the inductance value changes. The proposed circuit can be widely utilized to ensure the stable operation of various systems, as inductor values in PMICs may fluctuate despite being identical components. The proposed Inductance-Variation-Insensitive (IVI) buck converter directly senses the rate of change of inductor current and transmits information about the output voltage and inductance to a dynamic ramp generator. The dynamic ramp generator produces a ramp signal proportionate to the sensed inductor current slope, thereby maintaining a deadbeat state and preventing subharmonic oscillations. This innovative approach enables the converter to function seamlessly across a wide range of output values while maintaining overall stability. The proposed buck converter is fabricated using a 0.18 $\mu $ m 1P6M CMOS process, occupying an active area of $0.82~mm^{2}$ . Experimental results demonstrate its stable operation over a broad range of output voltages, even in the presence of inductance variations, when compared to conventional fixed-ramp approaches. It exhibits a transient response recovery time of 3.9 $\mu $ s for a load change from 50 mA to 350 mA and 4.7 $\mu $ s for the reverse change, from 350 mA to 50 mA. Furthermore, this brief achieves a maximum power efficiency of 90.5%, accompanied by an output ripple of less than 30 mV.

Published
2024
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47. Padina boergesenii mediated synthesis of Se-ZnO bimetallic nanoparticles for effective anticancer activity.

Author

Thirupathi, Balaji, Pongen, Yimtar Lanutoshi, Kaveriyappan, Govindarajan Rasiravathanahalli, Dara, Pavan Kumar, Rathinasamy, Suresh, Vinayagam, Saranya, Sundaram, Thanigaivel, Baek Kwang Hyun, Durairaj, Thirumurugan, and Sekar, Suresh Kumar Rajamani

Subjects
ANTINEOPLASTIC agents, NANOPARTICLES, BROWN algae, CELL lines, BREAST, BIOACTIVE compounds
Abstract

Introduction: Evaluating the anticancer property of Padina boergesenii mediated bimetallic nanoparticles. Methods: The present study focuses on synthesizing Se-ZnO bimetallic nanoparticles from an aqueous algal extract of brown algae Padina boergesenii. Synthesized Se-ZnO NPs were characterized by UV, FTIR, SEM-EDS and HRTEM for confirmation along with the anticancer activity by MTT assay. Results: The UV gave an absorbance peak at 342 and 370 nm, and the FTIR showed functional groups involved in synthesizing Se-ZnO NPs. The TEM micrographs indicated the crystalline nature and confirmed the size of the Se-ZnO NPs to be at an average size of 26.14 nm. Anticancer efficacy against the MCF-7 breast and HepG2 (hepatoblastoma) cell lines were also demonstrated, attaining an IC50 value of 67.9 µg and 74.9 µg/ml respectively, which caused 50% cell death. Discussion: This work aims to highlight an effective method for delivering bioactive compounds extracted from brown algae and emphasize its future therapeutic prospects. The potential of Selenium-Zinc oxide nanoparticles is of great interest due to the biocompatibility and low toxicity aspects of selenium combined with the cost-effectiveness and sustainability of zinc metal. The presence of bioactive compounds contributed to the stability of the nanoparticles and acted as capping properties. [ABSTRACT FROM AUTHOR]

Published
2024
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