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2. Efficacy of the 1-year (13-cycle) segesterone acetate and ethinylestradiol contraceptive vaginal system: results of two multicentre, open-label, single-arm, phase 3 trials

Author

Archer, David F, Merkatz, Ruth B, Bahamondes, Luis, Westhoff, Carolyn L, Darney, Philip, Apter, Dan, Jensen, Jeffrey T, Brache, Vivian, Nelson, Anita L, Banks, Erika, Bártfai, György, Portman, David J, Plagianos, Marlena, Dart, Clint, Kumar, Narender, Creasy, George W, Sitruk-Ware, Regine, and Blithe, Diana L

Published
2019
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3. Monitoring of Fetal Heart Rate via iPhone

Author

Sipka, Gábor, Szabó, Tibor, Zölei-Szénási, Ráhel, Vanya, Melinda, Jakó, Mária, Nagy, Tamás Dániel, Fidrich, Márta, Bilicki, Vilmos, Borbás, János, Bitó, Tamás, Bártfai, György, Akan, Ozgur, Series editor, Bellavista, Paolo, Series editor, Cao, Jiannong, Series editor, Coulson, Geoffrey, Series editor, Dressler, Falko, Series editor, Ferrari, Domenico, Series editor, Gerla, Mario, Series editor, Kobayashi, Hisashi, Series editor, Palazzo, Sergio, Series editor, Sahni, Sartaj, Series editor, Shen, Xuemin Sherman, Series editor, Stan, Mircea, Series editor, Xiaohua, Jia, Series editor, Zomaya, Albert Y., Series editor, Giokas, Kostas, editor, Bokor, Laszlo, editor, and Hopfgartner, Frank, editor

Published
2017
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4. Use of Infertility Handling Among Women of Reproductive Age

Author

Vanya, Melinda, Jakó, Mária, Füle, Győző, Fidrich, Márta, Surányi, Andrea, Bitó, Tamás, Bártfai, György, Akan, Ozgur, Series editor, Bellavista, Paolo, Series editor, Cao, Jiannong, Series editor, Coulson, Geoffrey, Series editor, Dressler, Falko, Series editor, Ferrari, Domenico, Series editor, Gerla, Mario, Series editor, Kobayashi, Hisashi, Series editor, Palazzo, Sergio, Series editor, Sahni, Sartaj, Series editor, Shen, Xuemin Sherman, Series editor, Stan, Mircea, Series editor, Xiaohua, Jia, Series editor, Zomaya, Albert Y., Series editor, Giokas, Kostas, editor, Bokor, Laszlo, editor, and Hopfgartner, Frank, editor

Published
2017
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5. Changes in prevalence of obesity and high waist circumference over four years across European regions: the European male ageing study (EMAS)

Author

Han, Thang S., Correa, Elon, Lean, Michael E. J., Lee, David M., O’Neill, Terrence W., Bartfai, György, Forti, Gianni, Giwercman, Aleksander, Kula, Krzysztof, Pendleton, Neil, Punab, Margus, Rutter, Martin K., Vanderschueren, Dirk, Huhtaniemi, Ilpo T., Wu, Frederick C. W., Casanueva, Felipe F., and and the EMAS Study Group

Published
2017
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6. Reproductive Hormone Levels Predict Changes in Frailty Status in Community-Dwelling Older Men: European Male Ageing Study Prospective Data

Author

Swiecicka, Agnieszka, Eendebak, Robert J A H, Lunt, Mark, O’Neill, Terence W, Bartfai, György, Casanueva, Felipe F, Forti, Gianni, Giwercman, Aleksander, Han, Thang S, Slowikowska-Hilczer, Jolanta, Lean, Michael E J, Pendleton, Neil, Punab, Margus, Vanderschueren, Dirk, Huhtaniemi, Ilpo T, Wu, Frederick C W, and Rutter, Martin K

Published
2018
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7. Chronic widespread pain is associated with worsening frailty in European men

Author

Wade, Katie Fredrika, Lee, David M., McBeth, John, Ravindrarajah, Rathi, Gielen, Evelien, Pye, Stephen R., Vanderschueren, Dirk, Pendleton, Neil, Finn, Joseph D., Bartfai, György, Casanueva, Felipe F., Forti, Gianni, Giwercman, Aleksander, Huhtaniemi, Ilpo T., Kula, Krzysztof, Punab, Margus, Wu, Frederick C. W., and OʼNeill, Terence W.

Published
2016
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8. Low heel ultrasound parameters predict mortality in men: results from the European Male Ageing Study (EMAS)

Author

Pye, Stephen R., Vanderschueren, Dirk, Boonen, Steven, Gielen, Evelien, Adams, Judith E., Ward, Kate A., Lee, David M., Bartfai, György, Casanueva, Felipe F., Finn, Joseph D., Forti, Gianni, Giwercman, Aleksander, Han, Thang S., Huhtaniemi, Ilpo T., Kula, Krzysztof, Lean, Michael E., Pendleton, Neil, Punab, Margus, Wu, Frederick C., and OʼNeill, Terence W.

Published
2015
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9. Association of 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D and parathyroid hormone with mortality among middle-aged and older European men

Author

Lee, David M., Vanderschueren, Dirk, Boonen, Steven, OʼNeill, Terence W., Pendleton, Neil, Pye, Stephen R., Ravindrarajah, Rathi, Gielen, Evelien, Claessens, Frank, Bartfai, György, Casanueva, Felipe F., Finn, Joseph D., Forti, Gianni, Giwercman, Aleksander, Han, Thang S., Huhtaniemi, Ilpo T., Kula, Krzysztof, Lean, Michael E. J., Punab, Margus, and Wu, Frederick C. W.

Published
2014
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10. Frailty and Sexual Health in Older European Men

Author

Lee, David M., Tajar, Abdelouahid, Ravindrarajah, Rathi, Pye, Stephen R., O’Connor, Daryl B., Corona, Giovanni, O’Connell, Matthew, Gielen, Evelien, Boonen, Steven, Vanderschueren, Dirk, Pendleton, Neil, Finn, Joseph D., Bartfai, György, Casanueva, Felipe F., Forti, Gianni, Giwercman, Aleksander, Han, Thang S., Huhtaniemi, Ilpo T., Kula, Krzysztof, Lean, Michael E. J., Punab, Margus, Wu, Frederick C. W., and O’Neill, Terence W.

Published
2013
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11. The association of frailty with serum 25-hydroxyvitamin D and parathyroid hormone levels in older European men

Author

Tajar, Abdelouahid, Lee, David M., Pye, Stephen R., OʼConnell, Matthew D. L., Ravindrarajah, Rathi, Gielen, Evelien, Boonen, Steven, Vanderschueren, Dirk, Pendleton, Neil, Finn, Joseph D., Bartfai, György, Casanueva, Felipe F., Forti, Gianni, Giwercman, Aleksander, Han, Thang S., Huhtaniemi, Ilpo T., Kula, Krzysztof, Lean, Michael E. J., Punab, Margus, Wu, Frederick C. W., and OʼNeill, Terence W.

Published
2013
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12. Characteristics of Androgen Deficiency in Late-Onset Hypogonadism: Results from the European Male Aging Study (EMAS)

Author

Tajar, Abdelouahid, Huhtaniemi, Ilpo T., OʼNeill, Terence W., Finn, Joseph D., Pye, Stephen R., Lee, David M., Bartfai, György, Boonen, Steven, Casanueva, Felipe F. F., Forti, Gianni, Giwercman, Aleksander, Han, Thang S., Kula, Krzysztof, Labrie, Fernand, Lean, Michael E. J., Pendleton, Neil, Punab, Margus, Vanderschueren, Dirk, and Wu, Frederick C. W.

Published
2012

13. Frailty in Relation to Variations in Hormone Levels of the Hypothalamic–Pituitary–Testicular Axis in Older Men: Results From the European Male Aging Study

Author

Tajar, Abdelouahid, O'Connell, Matthew D.L., Mitnitski, Arnold B., O'Neill, Terence W., Searle, Samuel D., Huhtaniemi, Ilpo T., Finn, Joseph D., Bartfai, György, Boonen, Steven, Casanueva, Felipe F., Forti, Gianni, Giwercman, Aleksander, Han, Thang S., Kula, Krzysztof, Labrie, Fernand, Lean, Michael E.J., Pendleton, Neil, Punab, Margus, Silman, Alan J., Vanderschueren, Dirk, Rockwood, Kenneth, and Wu, Frederick C.W.

Published
2011
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14. Effect of Polymorphisms in Selected Genes Involved in Pituitary-Testicular Function on Reproductive Hormones and Phenotype in Aging Men

Author

Huhtaniemi, Ilpo T., Pye, Stephen R., Holliday, Kate L., Thomson, Wendy, OʼNeill, Terence W., Platt, Hazel, Payne, Debbie, John, Sally L., Jiang, Min, Bartfai, György, Boonen, Steven, Casanueva, Felipe F., Finn, Joseph D., Forti, Gianni, Giwercman, Aleksander, Han, Thang S., Kula, Krzysztof, Lean, Michael E. J., Pendleton, Neil, Punab, Margus, Silman, Alan J., Vanderschueren, Dirk, Labrie, Fernand, and Wu, Frederick C. W.

Published
2010

15. Characteristics of Secondary, Primary, and Compensated Hypogonadism in Aging Men: Evidence from the European Male Ageing Study

Author

Tajar, Abdelouahid, Forti, Gianni, OʼNeill, Terence W., Lee, David M., Silman, Alan J., Finn, Joseph D., Bartfai, György, Boonen, Steven, Casanueva, Felipe F., Giwercman, Aleksander, Han, Thang S., Kula, Krzysztof, Labrie, Fernand, Lean, Michael E. J., Pendleton, Neil, Punab, Margus, Vanderschueren, Dirk, Huhtaniemi, Ilpo T., and Wu, Frederick C. W.

Published
2010

16. Increased Estrogen Rather Than Decreased Androgen Action Is Associated with Longer Androgen Receptor CAG Repeats

Author

Huhtaniemi, Ilpo T., Pye, Stephen R., Limer, Kate L., Thomson, Wendy, OʼNeill, Terence W., Platt, Hazel, Payne, Debbie, John, Sally L., Jiang, Min, Boonen, Steven, Borghs, Herman, Vanderschueren, Dirk, Adams, Judith E., Ward, Kate A., Bartfai, György, Casanueva, Felipe, Finn, Joseph D., Forti, Gianni, Giwercman, Aleksander, Han, Thang S., Kula, Krzysztof, Lean, Michael E. J., Pendleton, Neil, Punab, Margus, Silman, Alan J., and Wu, Frederick C. W.

Published
2009

17. WHO multinational study of three misoprostol regimens after mifepristone for early medical abortion. I: Efficacy

Author

von Hertzen, Helena, Honkanen, Helena, Piaggio, Gilda, Bartfai, György, Erdenetungalag, Radnaabazar, Gemzell-Danielsson, Kristina, Gopalan, Sarala, Horga, Mihai, Jerve, Fridtjof, Mittal, Suneeta, Ngoc, Nguyen Thi Nhu, Peregoudov, Alexandre, Prasad, R.N.V, Pretnar-Darovec, Alenka, Shah, Rashmi S, Song, Si, Tang, Oi Shan, and Wu, Shang Chun

Published
2003
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18. Reproductive hormone levels predict changes in frailty status in community-dwelling older men:European Male Ageing Study prospective data

Author

Swiecicka, Agnieszka, Eendebak, Robert J.A.H., Lunt, Mark, O'Neill, Terence W., Bartfai, György, Casanueva, Felipe F., Forti, Gianni, Giwercman, Aleksander, Han, Thang S., Slowikowska-Hilczer, Jolanta, Lean, Michael E.J., Pendleton, Neil, Punab, Margus, Vanderschueren, Dirk, Huhtaniemi, Ilpo T., Wu, Frederick C.W., and Rutter, Martin K.

Abstract

CONTEXT: Clinical sequelae of androgen deficiency share common features with frailty. Evidence supporting the role of androgens in the development of frailty is limited and conflicting. OBJECTIVE: To determine associations between male reproductive hormones and prospective changes in frailty status. DESIGN/SETTING: A 4.3-year prospective cohort study of community-dwelling men participating in the European Male Ageing Study. PARTICIPANTS: A total of 3369 men aged 40 to 79 from eight European centers. INTERVENTION: None. MAIN OUTCOME MEASURE: Frailty status was determined using frailty index (FI; n = 2278) and frailty phenotype (FP; n = 1980). RESULTS: After adjusting for baseline frailty, age, center, and smoking, the risk of worsening FI decreased with higher testosterone (T), free T, and dihydrotestosterone (DHT) [percentage change (95% confidence interval) in FI associated with 1 standard deviation higher hormone level: -3.0 (-5.9, -1.0) for total T; -3.9 (-6.8, -2.0) for free T; and -3.9 (-6.8, -2.0) for DHT]. After further adjustment for body mass index, only free T remained a significant predictor of FI change. In fully adjusted models, higher luteinizing hormone and follicle-stimulating hormone were positively related to worsening FI only in men

Published
2018

21. Lower bone turnover and relative bone deficits in men with metabolic syndrome: a matter of insulin sensitivity? The European Male Ageing Study

Author

Laurent, Michaël, Cook, Michael, Gielen, Evelien, Ward, Kate A, Antonio, Leen, Adams, Judith E, Decallonne, Brigitte, Bartfai, György, Casanueva, Felipe F, Forti, Giani, Giwercman, Aleksander, Huhtaniemi, Ilpo T, Kula, Krzysztof, Lean, Michael EJ, Lee, David M, Pendleton, Neil, Punab, Margus, Claessens, Frank, Wu, Frederick CW, Vanderschueren, Dirk, Pye, Stephen R, O’Neill, Terence W, and EMAS, Group

Subjects
Adult, Male, 0301 basic medicine, musculoskeletal diseases, Aging, medicine.medical_specialty, Bone density, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Bone and Bones, Bone remodeling, 03 medical and health sciences, 0302 clinical medicine, Insulin resistance, N-terminal telopeptide, Bone Density, Internal medicine, medicine, Humans, Quantitative computed tomography, Aged, Femoral neck, Metabolic Syndrome, Bone mineral, medicine.diagnostic_test, business.industry, nutritional and metabolic diseases, Middle Aged, medicine.disease, Cross-Sectional Studies, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, Hyperglycemia, Bone Remodeling, Insulin Resistance, business, Body mass index
Abstract

UNLABELLED: We examined cross-sectional associations of metabolic syndrome and its components with male bone turnover, density and structure. Greater bone mass in men with metabolic syndrome was related to their greater body mass, whereas hyperglycaemia, hypertriglyceridaemia or impaired insulin sensitivity were associated with lower bone turnover and relative bone mass deficits. INTRODUCTION: Metabolic syndrome (MetS) has been associated with lower bone turnover and relative bone mass or strength deficits (i.e. not proportionate to body mass index, BMI), but the relative contributions of MetS components related to insulin sensitivity or obesity to male bone health remain unclear. METHODS: We determined cross-sectional associations of MetS, its components and insulin sensitivity (by homeostatic model assessment-insulin sensitivity (HOMA-S)) using linear regression models adjusted for age, centre, smoking, alcohol, and BMI. Bone turnover markers and heel broadband ultrasound attenuation (BUA) were measured in 3129 men aged 40-79. Two centres measured total hip, femoral neck, and lumbar spine areal bone mineral density (aBMD, n = 527) and performed radius peripheral quantitative computed tomography (pQCT, n = 595). RESULTS: MetS was present in 975 men (31.2 %). Men with MetS had lower β C-terminal cross-linked telopeptide (β-CTX), N-terminal propeptide of type I procollagen (PINP) and osteocalcin (P

Published
2016

22. The androgen receptor gene CAG repeat in relation to 4-year changes in androgen-sensitive endpoints in community-dwelling older European men

Author

Eendebak, Robert J A H, primary, Huhtaniemi, Ilpo T, additional, Pye, Stephen R, additional, Ahern, Tomas, additional, O’Neill, Terence W, additional, Bartfai, György, additional, Casanueva, Felipe F, additional, Maggi, Mario, additional, Forti, Gianni, additional, Alston, Robert D, additional, Giwercman, Aleksander, additional, Han, Thang S, additional, Kula, Krzysztof, additional, Lean, Michael E J, additional, Punab, Margus, additional, Pendleton, Neil, additional, Keevil, Brian G, additional, Vanderschueren, Dirk, additional, Rutter, Martin K, additional, Tampubolon, Gindo, additional, Goodacre, Royston, additional, Wu, Frederick C W, additional, and _, _, additional

Published
2016
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23. Chronic widespread pain is associated with worsening frailty in European men

Author

Wade, Katie Fredrika, primary, Lee, David M., additional, McBeth, John, additional, Ravindrarajah, Rathi, additional, Gielen, Evelien, additional, Pye, Stephen R., additional, Vanderschueren, Dirk, additional, Pendleton, Neil, additional, Finn, Joseph D., additional, Bartfai, György, additional, Casanueva, Felipe F., additional, Forti, Gianni, additional, Giwercman, Aleksander, additional, Huhtaniemi, Ilpo T., additional, Kula, Krzysztof, additional, Punab, Margus, additional, Wu, Frederick C. W., additional, and O'Neill, Terence W., additional

Published
2015
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24. Natural history, risk factors and clinical features of primary hypogonadism in ageing men: Longitudinal Data from the European Male Ageing Study.

Author

Ahern, Tomás, Swiecicka, Agnieszka, Eendebak, Robert J.A.H., Carter, Emma L., Finn, Joseph D., Pye, Stephen R., O'Neill, Terence W., Antonio, Leen, Keevil, Brian, Bartfai, György, Casanueva, Felipe F., Forti, Gianni, Giwercman, Aleksander, Han, Thang S., Kula, Krzysztof, Lean, Michael E.J., Pendleton, Neil, Punab, Margus, Rastrelli, Giulia, and Rutter, Martin K

Subjects
TESTOSTERONE, LUTEINIZING hormone, HYPOGONADISM, REGRESSION analysis, INSULIN resistance
Abstract

Objective In ageing men, the incidence and clinical significance of testosterone (T) decline accompanied by elevated luteinizing hormone ( LH) are unclear. We describe the natural history, risk factors and clinical features associated with the development of biochemical primary hypogonadism ( PHG, T < 10·5 nmol/l and LH>9·4U/l) in ageing men. Design, Patients and Measurements A prospective observational cohort survey of 3,369 community-dwelling men aged 40-79 years, followed up for 4·3 years. Men were classified as incident (i) PHG (eugonadal [ EUG, T ≥ 10·5 nmol/l] at baseline, PHG at follow-up), persistent (p) PHG ( PHG at baseline and follow-up), pEUG ( EUG at baseline and follow-up) and reversed (r) PHG ( PHG at baseline, EUG at follow-up). Predictors and changes in clinical features associated with the development of PHG were analysed by regression models. Results Of 1,991 men comprising the analytical sample, 97·5% had pEUG, 1·1% iPHG, 1·1% pPHG and 0·3% rPHG. The incidence of PHG was 0·2%/year. Higher age (>70 years) [ OR 12·48 (1·27-122·13), P = 0·030] and chronic illnesses [ OR 4·24 (1·08-16·56); P = 0·038] predicted iPHG. Upon transition from EUG to PHG, erectile function, physical vigour and haemoglobin worsened significantly. Men with pPHG had decreased morning erections, sexual thoughts and haemoglobin with increased insulin resistance. Conclusions Primary testicular failure in men is uncommon and predicted by old age and chronic illness. Some clinical features attributable to androgen deficiency, but not others, accompanied the T decline in men who developed biochemical PHG. Whether androgen replacement can improve sexual and/or physical function in elderly men with PHG merits further study. [ABSTRACT FROM AUTHOR]

Published
2016
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25. Association of 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D and parathyroid hormone with mortality among middle-aged and older European men

Author

Lee, David M., primary, Vanderschueren, Dirk, additional, Boonen, Steven, additional, O'Neill, Terence W., additional, Pendleton, Neil, additional, Pye, Stephen R., additional, Ravindrarajah, Rathi, additional, Gielen, Evelien, additional, Claessens, Frank, additional, Bartfai, György, additional, Casanueva, Felipe F., additional, Finn, Joseph D., additional, Forti, Gianni, additional, Giwercman, Aleksander, additional, Han, Thang S., additional, Huhtaniemi, Ilpo T., additional, Kula, Krzysztof, additional, Lean, Michael E. J., additional, Punab, Margus, additional, and Wu, Frederick C. W., additional

Published
2013
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26. The ability of three different models of frailty to predict all-cause mortality: Results from the European Male Aging Study (EMAS)

Author

Ravindrarajah, Rathi, primary, Lee, David M., additional, Pye, Stephen R., additional, Gielen, Evelien, additional, Boonen, Steven, additional, Vanderschueren, Dirk, additional, Pendleton, Neil, additional, Finn, Joseph D., additional, Tajar, Abdelouahid, additional, O’Connell, Matthew D.L., additional, Rockwood, Kenneth, additional, Bartfai, György, additional, Casanueva, Felipe F., additional, Forti, Gianni, additional, Giwercman, Aleksander, additional, Han, Thang S., additional, Huhtaniemi, Ilpo T., additional, Kula, Krzysztof, additional, Lean, Michael E.J., additional, Punab, Margus, additional, Wu, Frederick C.W., additional, and O’Neill, Terence W., additional

Published
2013
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28. Chronic widespread pain is associated with worsening frailty in European men.

Author

FREDRIKAWADE, KATIE, LEE, DAVID M., MCBETH, JOHN, RAVINDRARAJAH, RATHI, GIELEN, EVELIEN, PYE, STEPHEN R., VANDERSCHUEREN, DIRK, PENDLETON, NEIL, FINN, JOSEPH D., BARTFAI, GYÖRGY, CASANUEVA, FELIPE F., FORTI, GIANNI, GIWERCMAN, ALEKSANDER, HUHTANIEMI, ILPO T., KULA, KRZYSZTOF, PUNAB, MARGUS, WU, FREDERICK C. W., and O'NEILL, TERENCE W.

Subjects
CHRONIC pain, CONFIDENCE intervals, FRAIL elderly, HEALTH surveys, LONGITUDINAL method, MEDICAL screening, MEN, QUESTIONNAIRES, STATISTICS, T-test (Statistics), DATA analysis, DATA analysis software, DESCRIPTIVE statistics, ODDS ratio, MANN Whitney U Test, DISEASE complications
Abstract

Background: we hypothesised that chronic widespread pain (CWP), by acting as a potential stressor, may predispose to the development of, or worsening, frailty. Setting: longitudinal analysis within the European Male Ageing Study (EMAS). Participants: a total of 2,736 community-dwelling men aged 40-79. Methods: subjects completed a pain questionnaire and shaded a manikin, with the presence of CWP defined using the American College of Rheumatology criteria. Physical activity, smoking, alcohol consumption and depression were measured. Repeat assessments took place a median of 4.3 years later. A frailty index (FI) was used, with frail defined as an FI >0.35. The association between CWP at baseline and the new occurrence of frailty was examined using logistic regression; the association between CWP at baseline and change in FI was examined using negative binomial regression. Results: at baseline, 218 (8.3%) men reported CWP. Of the 2,631 men who were defined as non-frail at baseline, 112 (4.3%) were frail at follow-up; their mean FI was 0.12 (SD 0.1) at baseline and 0.15 (SD 0.1) at follow-up, with a mean change of 0.03 (SD 0.08) P ≤ 0.001. Among men who were non-frail at baseline, those with CWP were significantly more likely to develop frailty. After adjustment for age and centre, compared with those with no pain, those with CWP at baseline had a 70% higher FI at follow-up; these associations remained significant after further adjustment for smoking, body mass index, depression, physical activity and FI at baseline. Conclusion: the presence of CWP is associated with an increased risk of frailty in older European men. [ABSTRACT FROM AUTHOR]

Published
2016
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29. Comparison of serum testosterone and estradiol measurements in 3174 European men using platform immunoassay and mass spectrometry; relevance for the diagnostics in aging men

Author

Huhtaniemi, Ilpo T, primary, Tajar, Abdelouahid, additional, Lee, David M, additional, O'Neill, Terence W, additional, Finn, Joseph D, additional, Bartfai, György, additional, Boonen, Steven, additional, Casanueva, Felipe F, additional, Giwercman, Aleksander, additional, Han, Thang S, additional, Kula, Krzysztof, additional, Labrie, Fernand, additional, Lean, Michael E J, additional, Pendleton, Neil, additional, Punab, Margus, additional, Silman, Alan J, additional, Vanderschueren, Dirk, additional, Forti, Gianni, additional, Wu, Frederick C W, additional, and _, _, additional

Published
2012
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30. Nonandrogenic Anabolic Hormones Predict Risk of Frailty: European Male Ageing Study Prospective Data.

Author

Swiecicka, Agnieszka, Lunt, Mark, Ahern, Tomás, O'Neill, Terence W, Bartfai, György, Casanueva, Felipe F, Forti, Gianni, Giwercman, Aleksander, Han, Thang S, Lean, Michael E J, Pendleton, Neil, Punab, Margus, Slowikowska-Hilczer, Jolanta, Vanderschueren, Dirk, Huhtaniemi, Ilpo T, Wu, Frederick C W, and Rutter, Martin K

Abstract

Low levels of nonandrogenic anabolic hormones have been linked with frailty, but evidence is conflicting and prospective data are largely lacking.

Published
2017
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31. Impaired quality of life and sexual function in overweight and obese men: the European Male Ageing Study

Author

Han, Thang S, primary, Tajar, Abdelouahid, additional, O'Neill, Terence W, additional, Jiang, Min, additional, Bartfai, György, additional, Boonen, Steven, additional, Casanueva, Felipe, additional, Finn, Joseph D, additional, Forti, Gianni, additional, Giwercman, Aleksander, additional, Huhtaniemi, Ilpo T, additional, Kula, Krzysztof, additional, Pendleton, Neil, additional, Punab, Margus, additional, Silman, Alan J, additional, Vanderschueren, Dirk, additional, Lean, Michael E J, additional, Wu, Frederick C W, additional, and _, _, additional

Published
2011
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32. Androgen Receptor Polymorphism-Dependent Variation in Prostate-Specific Antigen Concentrations of European Men.

Author

Holgersson, Magdalena Bentmar, Giwercman, Aleksander, Bjartell, Anders, Wu, Frederick C.W., Huhtaniemi, Ilpo T., O'Neill, Terence W., Pendleton, Neil, Vanderschueren, Dirk, Lean, Michael E. J., Han, Thang S., Finn, Joseph D., Kula, Krzysztof, Forti, Gianni, Casanueva, Felipe F., Bartfai, György, Punab, Margus, and Giwercman, Yvonne Lundberg

Abstract

The article discusses a study to investigate the association of androgen receptor variants with the risk of prostate-specific antigen (PSA) concentrations and its impact on the risk of being diagnosed with prostate cancer. Topics discussed include need of improving Serum PSA, a clinical marker with the adjustment of AR genotype, use the European Male Ageing Study (EMAS) to provide baseline information, and benefits of screening prostate cancer using PSA measurements.

Published
2014
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33. Low Free Testosterone Is Associated with Hypogonadal Signs and Symptoms in Men with Normal Total Testosterone

Author

Antonio, Leen, Wu, Frederick C. W., O'Neill, Terence W., Pye, Stephen R., Ahern, Tomas B., Laurent, Michaël R., Huhtaniemi, Ilpo T., Lean, Michael E. J., Keevil, Brian G., Rastrelli, Giulia, Forti, Gianni, Bartfai, György, Casanueva, Felipe F., Kula, Krzysztof, Punab, Margus, Giwercman, Aleksander, Claessens, Frank, Decallonne, Brigitte, and Vanderschueren, Dirk

Abstract

Context:During aging, total testosterone (TT) declines and SHBG increases, resulting in a greater decrease in calculated free T (cFT). Currently, guidelines suggest using TT to diagnose androgen deficiency and to reserve cFT only for men with borderline TT.Objective:Our objective was to investigate if either low cFT or low TT is more strongly associated with androgen-related clinical endpoints.Methods:A total of 3334 community-dwelling men, aged 40—79 years, were included in this study. Differences in clinical variables between the referent group of men with both normal TT (≥10.5 nmol/liter) and normal cFT (≥220 pmol/liter) with those who had normal TT/low cFT, low TT/normal cFT, and low TT/low cFT were assessed by regression models adjusted for age, center, body mass index, and comorbidities.Results:A total of 2641 men had normal TT (18.4 ± 5.5 [mean ± SD] nmol/liter)/normal cFT (326 ± 74 pmol/liter), 277 men had normal TT (14.2 ± 3.7)/low cFT (194 ± 23), 96 men had low TT (9.6 ± 0.7)/normal cFT (247 ± 20), and 320 men had low TT (7.8 ± 2.5)/low cFT (160 ± 55). Men with normal TT/low cFT were older and in poorer health. They had higher SHBG and LH and reported more sexual and physical symptoms, whereas hemoglobin and bone ultrasound parameters were lower compared to the referent group. Men with low TT/normal cFT were younger and more obese. They had lower SHBG, but LH was normal, whereas features of androgen deficiency were lacking.Conclusions:Low cFT, even in the presence of normal TT, is associated with androgen deficiency-related symptoms. Normal cFT, despite low TT, is not associated with cognate symptoms; therefore, cFT levels should be assessed in men with suspected hypogonadal symptoms.

Published
2016
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34. Pregnancy and perinatal outcomes among women with multiple sclerosis: a retrospective case-controlled study in South Hungary.

Author

Vanya, Melinda, Nyari, Tibor, Bencsik, Krisztina, and Bartfai, György

Subjects
FETAL death, MISCARRIAGE, MULTIPLE sclerosis, FIRST trimester of pregnancy, CASE-control method
Abstract

Objective: The aim of this study was to investigate the connections between multiple sclerosis (MS) and fertility, pregnancy. Methods: The case histories and pregnancy complications in a sample of 65 treatment-naive pregnant women with MS in the period 1998-2012 were compared with an age-matched case-controlled analysis. Comparisons were made between primigravidas and multigravidas subjects. Results: Our results revealed a higher rate of miscarriage (18.46%) in the first trimester in women with MS, and intrauterine death (7.69%) in the third trimester, as compared with women without MS ( p < 0.001 and p = 0.035). Conclusions: These findings suggest that, the risk of miscarriages and intrauterine death may be disease-related not drug-related feature. Further studies are needed to determine to possible associated factors of miscarriages. [ABSTRACT FROM AUTHOR]

Published
2014
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35. Androgen receptor polymorphism-dependent variation in prostate-specific antigen concentrations of European men.

Author

Bentmar Holgersson M, Giwercman A, Bjartell A, Wu FC, Huhtaniemi IT, O'Neill TW, Pendleton N, Vanderschueren D, Lean ME, Han TS, Finn JD, Kula K, Forti G, Casanueva FF, Bartfai G, Punab M, and Lundberg Giwercman Y

Subjects
Adult, Aged, Electrochemical Techniques, Europe, Genotype, Humans, Immunoassay, Male, Middle Aged, Polymorphism, Single Nucleotide, Prostate-Specific Antigen blood, Prostate-Specific Antigen genetics, Receptors, Androgen genetics
Abstract

Background: Androgens acting via the androgen receptor (AR) stimulate production of PSA, which is a clinical marker of prostate cancer. Because genetic variants in the AR may have a significant impact on the risk of being diagnosed with prostate cancer, the aim was to investigate whether AR variants were associated with the risk of having PSA above clinically used cutoff thresholds of 3 or 4 ng/mL in men without prostate cancer., Methods: Men without prostate cancer history (n = 1,744) were selected from the European Male Ageing Study cohort of 40 to 79-year-old men from eight different European centers. Using linear and logistic regression models, with age and center as covariates, we investigated whether AR variants (CAG repeat-length and/or SNP genotype) were associated with having serum PSA concentrations above 3 or 4 ng/mL, which often are set as cutoff concentrations for further investigation of prostate cancer., Results: Carriers of the SNP rs1204038 A-allele (16% of the men) were more likely to have PSA>3 and 4 ng/mL (OR; 95% confidence intervals, 1.65; 1.13-2.40 and 1.87; 1.18-2.96, respectively) than G-allele carriers. They also had shorter CAG repeats (median 20 vs. 23, P < 0.0005), but CAG repeat length per se did not affect the PSA concentrations., Conclusion: The A-allele of the SNP rs1204038 gives a 65% higher risk of having PSA above 3 ng/mL than the G-allele in men without prostate cancer, and thereby an increased risk of being referred for further examination on suspicion of prostate cancer., Impact: Serum PSA as a clinical marker could be improved by adjustment for AR-genotype., (©2014 American Association for Cancer Research.)

Published
2014
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