1. Synthesis and therapeutic applications of biocompatible or biodegradable hyperbranched polymers
- Author
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Deyue Yan, Dali Wang, Rongjun Chen, Xinyuan Zhu, and Yu Huang
- Subjects
Materials science ,Polymers and Plastics ,Hyperbranched polymers ,TRANSFER RADICAL POLYMERIZATION ,Polymer Science ,Bioengineering ,Nanotechnology ,Modification ,Biochemistry ,MULTIFUNCTIONAL UNIMOLECULAR MICELLES ,THIOL-YNE CHEMISTRY ,TARGETED DRUG-DELIVERY ,Synthesis ,DENDRITIC MULTISHELL ARCHITECTURES ,Science & Technology ,DIFFERENT BRANCHED ARCHITECTURE ,Organic Chemistry ,PROTON-TRANSFER POLYMERIZATION ,Therapeutic applications ,Biocompatible material ,RING-OPENING POLYMERIZATION ,Biodegradability ,BB'(2) TYPE MONOMERS ,Physical Sciences ,Biocompatibility ,EFFICIENT GENE DELIVERY ,0303 Macromolecular And Materials Chemistry - Abstract
Biocompatible or biodegradable hyperbranched polymers (HBPs), an important subclass of hyperbranched macromolecules, have recently received an increasing attention due to their unique physical and chemical properties as well as their great advantages in therapeutic applications. This review highlights recent advances and future trends in the preparation and applications of biocompatible or biodegradable HBPs for therapeutic purpose. Various biocompatible or biodegradable hyperbranched structures can be obtained by means of step-growth polycondensation (SGP), self-condensing vinyl polymerization (SCVP), self-condensing ring-opening polymerization (SCROP), and so forth. The properties of biocompatible or biodegradable HBPs can be tailored for a specialized purpose through terminal modification, backbone modification, or hybrid modification. A particular emphasis is then placed on their diagnostic, therapeutic delivery and theranostic applications. Finally, future directions and perspectives in this emerging field are briefly discussed. These developments on synthesis and therapeutic applications of biocompatible or biodegradable HBPs promote the interdisciplinary research spanning polymer materials and biomedical sciences.
- Published
- 2015