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La fréquence du déficit en vitamine D est croissante au Maroc. Cette vitamine est capitale pour la santé. Son déficit peut engendrer des maladies osseuses et extra-osseuses. L'objectif de notre travail est de déterminer les degrés de sévérité de l'hypovitaminose D et de montrer l'utilité d'introduire cette vitamine dans la liste des médicaments essentiels. Nous avons effectué une étude rétrospective auprès de cinq laboratoires de la région Rabat-Salé-Kénitra. L'enquête a inclus les patients qui se sont présentés pour un dosage de la vitamineD. Les variables étudiées sont le sexe, l'âge et le statut vitaminique. On a recensé 862 patients. L'âge moyen est de 51 ± 13,76 ans. La valeur moyenne du dosage de la vitamine D est de 15,7 ± 9,87 ng/mL. Nous avons enregistré une insuffisance de 62,5 %. Au vu de ces résultats, il semble justifié d'introduire la vitamine D dans la liste des médicaments essentiels. [ABSTRACT FROM AUTHOR]

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Purpose: To estimate the relative frequency of reported adverse drug reactions during the malaria chemoprophylactic period of the Moroccan contingent in Democratic Republic of Congo (DRC)., Methods: The transversal survey involved all military personnel of the Moroccan contingent and was carried out using a questionnaire to be filled out by a multidisciplinary medical team. It was performed in all the military sites and the advanced posts accessible during the period of the study., Results: The study involved 362 male military subjects. Ninety-four adverse drug reactions were described: neuropsychiatric (anxiety, irritability, dizziness...) [n=76], digestive (anorexia, diarrhea, nausea...) [n=42], cardiovascular (tachycardia, palpitation, precordialgia...) [n=5], musculoskeletal (arthralgia, cramps) [n=4], cutaneous (redness, purpura) [n=2], and other (n=13). No "unexpected" or "serious" adverse drug reaction was reported. The causality assessment score was determined in 94 cases. Two of these reports were rated "likely", 12 "possible" and 80 doubtful. More adverse drug reactions were reported by subjects having medical and paramedical functions., Conclusion: During our study, mefloquine induced adverse drug reactions in a quarter of the treated subjects. Most of the adverse drug reactions were neuropsychiatric. No "serious" adverse drug reactions were reported underlying the interest of its use, even for long-term chemoprophylaxis.

Unlabelled: The objective of our survey is to value the availability of the antidotes in the main Moroccan hospitals., Material and Method: A questionnaire constituted of 15 items and permitting to appreciate the availability of 43 antidotes selected in the literature, has been addressed to 9 hospitals of which 3 soldiers., Results: Five per cent of the antidotes were available in all hospitals having answered to our questionnaire. Forty two per cent of the antidotes missed to all structures, the rest (47%) had a variable availability according to the structures. The list of the missing antidotes is long and contains classified vital products of group A of the recommendations of the IPCS (International Program on Chemical Safety) like the specific antibodies of the digoxine and the methylene blue., Conclusion: The found results are troubling and often unveil sometimes a big problem of management of these products vital and constituent the unique treatment.