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5. Leptin Is Associated with Testosterone, Nutritional Markers, and Vascular Muscular Dysfunction in Chronic Kidney Disease.

Author

Rusu, Crina Claudia, Kacso, Ina, Moldovan, Diana, Potra, Alina, Tirinescu, Dacian, Ticala, Maria, Orasan, Remus, Budurea, Cristian, Anton, Florin, Valea, Ana, Bondor, Cosmina Ioana, and Carsote, Mara

Subjects
CHRONIC kidney failure, LEPTIN, ANKLE, TESTOSTERONE, PULSE wave analysis, LEPTIN receptors, PARATHYROID hormone
Abstract

Chronic kidney disease (CKD) causes specific hormonal disturbances, such as variations in leptin and testosterone levels and function. These disturbances can promote errors in signaling interaction and cellular information processing and can be implicated in the pathogenesis of atherosclerosis. This study investigates the factors that affect leptin in CKD patients and examines how leptin is related to markers of vascular disease. We conducted a cross-sectional study of 162 patients with CKD in pre-dialysis and dialysis stages. We recorded clinical and laboratory data, including leptin, testosterone, and subclinical atherosclerosis markers like brachial–ankle pulse wave velocity (ba PWV) in pre-dialysis CKD patients and flow-mediated vasodilation (FMD) and nitroglycerin-mediated vasodilation (NMD) in hemodialysis (HD) patients. Leptin was significantly correlated with testosterone in CKD pre-dialysis stages (p < 0.001) and also in HD (p = 0.026), with adipose tissue mass in pre-dialysis stages (p < 0.001), and also in HD (p < 0.001). In women HD patients, leptin correlated with NMD (p = 0.039; r = −0.379); in all HD patients, leptin correlated with C reactive protein (p = 0.007; r = 0.28) and parathormone (p = 0.039; r = −0.220). Our research emphasizes the connection between leptin, adipose tissue, and testosterone in all stages of CKD. Leptin was associated with NMD in HD women and correlated with inflammatory syndrome and parathyroid hormone in all HD patients. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Association between Human Leukocyte Antigen and End-Stage Renal Disease in Patients from Transylvania, Romania

Author

Iancu Loga, Luminita-Ioana, primary, Dican, Lucia, additional, Chiorean, Alin Dan, additional, Chelaru, Vlad Florin, additional, Elec, Florin Ioan, additional, Catana, Cristina Sorina, additional, Marta, Monica Mihaela, additional, Lucaciu, Roxana Liana, additional, Hangan, Adriana Corina, additional, Bondor, Cosmina Ioana, additional, Vica, Mihaela Laura, additional, and Matei, Horea Vladi, additional

Published
2023
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11. Triiodothyronine and Protein Malnutrition Could Influence Pulse Wave Velocity in Pre-Dialysis Chronic Kidney Disease Patients

Author

Rusu, Crina Claudia, primary, Kacso, Ina, additional, Moldovan, Diana, additional, Potra, Alina, additional, Tirinescu, Dacian, additional, Ticala, Maria, additional, Rotar, Ancuta M., additional, Orasan, Remus, additional, Budurea, Cristian, additional, Barar, Andrada, additional, Anton, Florin, additional, Valea, Ana, additional, Bondor, Cosmina Ioana, additional, and Ticolea, Madalina, additional

Published
2023
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12. Ultrasound Placental Remodeling Patterns and Pathology Characteristics in Patients with History of Mild SARS-CoV-2 Infection during Pregnancy

Author

Staicu, Adelina, primary, Albu, Camelia, additional, Nemeti, Georgiana, additional, Bondor, Cosmina Ioana, additional, Boitor-Borza, Dan, additional, Preda, Andreia Paraschiva, additional, Florian, Andreea, additional, Goidescu, Iulian Gabriel, additional, Sachelaru, Diana, additional, Bora, Nelida, additional, Constantin, Roxana, additional, Surcel, Mihai, additional, Stamatian, Florin, additional, Rotar, Ioana Cristina, additional, Cruciat, Gheorghe, additional, and Muresan, Daniel, additional

Published
2023
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14. Safety of Electrotherapy Treatment in Patients with Knee Osteoarthritis and Cardiac Diseases

Author

Irsay, Laszlo, primary, Ungur, Rodica Ana, additional, Borda, Ileana Monica, additional, Tica, Irina, additional, Iliescu, Mădălina Gabriela, additional, Ciubean, Alina Deniza, additional, Popa, Theodor, additional, Cinteza, Delia, additional, Popa, Florina Ligia, additional, Bondor, Cosmina Ioana, additional, and Ciortea, Viorela Mihaela, additional

Published
2022
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28. Neutrophil-to-lymphocyte ratio, platelets-to-lymphocyte ratio, and eosinophils correlation with high-resolution computer tomography severity score in COVID-19 patients

Author

Man, Milena Adina, primary, Rajnoveanu, Ruxandra-Mioara, additional, Motoc, Nicoleta Stefania, additional, Bondor, Cosmina Ioana, additional, Chis, Ana Florica, additional, Lesan, Andrei, additional, Puiu, Ruxandra, additional, Lucaciu, Sergiu-Remus, additional, Dantes, Elena, additional, Gergely-Domokos, Bianca, additional, and Fira-Mladinescu, Ovidiu, additional

Published
2021
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29. Hemodialysis Patients with Higher Serum Levels of Soluble Receptor for Advanced Glycation End Products Have an Increased Risk for Arteriovenous Fistula Failure.

Author

Ticala, Maria, Rusu, Crina Claudia, Moldovan, Diana, Potra, Alina Ramona, Tirinescu, Dacian Călin, Coman, Anca Laura, Bondor, Cosmina Ioana, Budisan, Livia, and Kacsó, Ina Maria

Subjects
ADVANCED glycation end-products, ARTERIOVENOUS fistula, HEMODIALYSIS patients, MYOCARDIAL ischemia, ENZYME-linked immunosorbent assay
Abstract

Background: Arteriovenous fistula (AVF) failure due to thrombosis is a major cause of morbidity in patients undergoing regular hemodialysis (HD). Advanced glycation end products (AGEs) and their receptor (RAGE) might contribute to inflammation, neointimal hyperplasia, and thrombosis. RAGE has a C-truncated secretory receptor form, called soluble RAGE (sRAGE). In this study, we aimed to evaluate the association of serum sRAGE with AVF failure due to thrombosis in HD patients. Methods: Eighty-eight prevalent HD patients with functional AVF were included in the study. The presence of stenosis, clinical and laboratory data, and serum sRAGE was evaluated at inclusion. sRAGE concentration was measured by a competitive enzyme-linked immunosorbent assay, and stenosis was detected by ultrasound. Patients were prospectively followed up for 36 months. During this period, AVF failure (defined as the absence of blast or palpable thrill and impossible cannulation with 2 needles because of complete thrombosis) was noted and thrombosis was certified by ultrasound examination. Results: During follow-up, 16 (18.18%) patients lost their vascular access due to thrombosis. In multivariate Cox regression analysis, sRAGE was a significant predictor of vascular access thrombosis (hazard ratio = 1.15, 95% confidence interval: 1.03–1.25, p = 0.012). Kaplan-Meier analysis showed a significantly lower AVF patency time in patients with sRAGE >16.78 ng/mL than those with sRAGE <16.78 ng/mL (p = 0.02). In the subgroup of patients with stenosis at baseline, sRAGE, serum albumin, obesity, and ischemic heart disease were associated with thrombosis. Conclusion: In our study, baseline, systemic sRAGE is associated with the occurrence of thrombosis of AVF, and this marker has a significant impact on AVF survival. [ABSTRACT FROM AUTHOR]

Published
2022
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33. Relationship between vascular cell adhesion molecule-1 (VCAM-1), soluble receptor for advanced glycation end products (sRAGE) and functional hemodynamic parameters of arteriovenous fistula

Author

Ticala, Maria, primary, Rusu, Crina Claudia, additional, Moldovan, Diana, additional, Potra, Alina Ramona, additional, Tirinescu, Dacian Calin, additional, Coman, Anca Laura, additional, Bondor, Cosmina Ioana, additional, Budisan, Livia, additional, and Kacso, Ina Maria, additional

Published
2020
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34. Disease Perception and Coping with Emotional Distress During COVID-19 Pandemic: A Survey Among Medical Staff

Author

Man, Milena Adina, primary, Toma, Claudia, additional, Motoc, Nicoleta Stefania, additional, Necrelescu, Octavia Luiza, additional, Bondor, Cosmina Ioana, additional, Chis, Ana Florica, additional, Lesan, Andrei, additional, Pop, Carmen Monica, additional, Todea, Doina Adina, additional, Dantes, Elena, additional, Puiu, Ruxandra, additional, and Rajnoveanu, Ruxandra-Mioara, additional

Published
2020
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41. RADIOPACITY ANALYSIS OF SOME CHAIRSIDE COMPUTER-AIDED DESIGN-COMPUTER-AIDED MANUFACTURING MILLING MATERIALS.

Author

VARVARA, ADRIAN MIHAI, GASPARIK, CRISTINA, CULIC, BOGDAN, BONDOR, COSMINA IOANA, VARVARA, ELENA BIANCA, FURTOS, GABRIEL, MOLDOVAN, MARIOARA, and DUDEA, DIANA

Subjects
RADIOPACITY, CAD/CAM systems, CERAMIC materials, MATERIALS, LITHIUM silicates
Abstract

In this study, the radiopacity of chairside Computer-Aided Design-Computer-Aided Manufacturing (CAD-CAM) milling materials was evaluated in comparison with dental structures. 105 specimens of 7 different thicknesses from 5 different types of chairside CAD-CAM milling materials: feldspar ceramic, hybrid ceramic, lithium disilicate glass-ceramic, zirconiareinforced lithium silicate ceramic and a resin nano-ceramic were used for this in vitro study. Digital radiographs were obtained using an aluminum step wedge, a specimen of a tooth slice and 3 specimens from each material. Radiodensity was determined for each material using dedicated software. Lava Ultimate and Vita Suprinity were found as having higher radiopacity, whilst Vita Mark II and Vita Enamic were lower in radiopacity in comparison with dental structures. The radiodensity of Emax CAD was between enamel and dentine. Radiopacity of each CAD-CAM milling material was different and both material's type and thickness significantly affected the radiopacity. [ABSTRACT FROM AUTHOR]

Published
2019
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44. The metabolic hormone FGF21 is associated with endothelial dysfunction in hemodialysis patients

Author

Rusu, Crina Claudia, primary, Racasan, Simona, additional, Kacso, Ina Maria, additional, Moldovan, Diana, additional, Potra, Alina, additional, Tirinescu, Dacian, additional, Budurea, Cristian, additional, Orasan, Remus, additional, Patiu, Ioan Mihai, additional, Bondor, Cosmina Ioana, additional, Vladutiu, Dan, additional, and Caprioara, Mirela Gherman, additional

Published
2016
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49. 276G>T Polymorphism of the ADIPOQ Gene Influences Plasma Adiponectin in Type 2 Diabetes Patients but Is Not Predictive for Presence of Type 2 Diabetes in a Caucasian Cohort from Romania

Author

KACSO, Ina Maria, FARCAS, Marius Florin, POP, Ioan Victor, BONDOR, Cosmina Ioana, POTRA, Alina Ramona, MOLDOVAN, Diana, RUSU, Crina, NITA, Cristina, GHERMAN, Caprioara Mirela, and HANCU, Nicolae Dumitru

Subjects
Original Papers
Abstract

Previous reports associated ADIPOQ 276GT polymorphism with plasma adiponectin levels and diabetes. Our objective was to study this polymorphism in type 2 diabetes (T2D) Romanian patients and to assess its influence on plasma adiponectin levels; possible link to prevalence of T2D was also addressed.Case control studyMaterial and Methods: Consecutive T2D patients, age and sex matched controls were genotyped for the 276 ADIPOQ locus. Medical history, laboratory evaluation, plasma adiponectin were assessed.105 T2D patients and 48 controls were included. Adiponectin was higher in controls (17.04±3.02 µg/ml) than in T2D patients (10.32±1.16 µg/ml), difference failed to reach significance (p=0.06). Genotype distribution wasn't different between T2D patients and controls. 44 (41.90%) of T2D patients had GG genotype, 51 (48.57%) GT and 10 (9.52%) TT genotype. Adiponectin was higher (19.03±3.46 µg/ml) in diabetic TT allele carriers than in GT (9.96±1.76 µg/ml) or GG patients (8.71±1.60 µg/ml) p=0.003. In controls, 28 (58.33 %) subjects were carriers of the GG genotype, 16 (33.33%) had GT genotype and 4 (8.33%) had TT genotype. There weren't significant differences in the studied parameters between different genotypes in the control group. Logistic regression disclosed age p=0.0001 (OR 1.086; CI 1.041/1.133), waist circumference p=0.00049 (OR 1.084; CI 1.036/1.135), adiponectinemia p=0.036 (OR 0.963; CI 0.929/0.998) but not genotype as predictors for the presence of diabetes.Presence of the TT allele at the 276 locus of the ADIPOQ gene is associated with higher plasma adiponectin levels in type 2 diabetes patients. Plasma adiponectin, and not genotype at the 276 locus is predictive for the presence of T2D.

Published
2012

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