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320 results on '"BONGIORNO, Maria Rita"'

1. Recapitulating thyroid cancer histotypes through engineering embryonic stem cells

Author

Veschi, Veronica, Turdo, Alice, Modica, Chiara, Verona, Francesco, Di Franco, Simone, Gaggianesi, Miriam, Tirrò, Elena, Di Bella, Sebastiano, Iacono, Melania Lo, Pantina, Vincenzo Davide, Porcelli, Gaetana, Mangiapane, Laura Rosa, Bianca, Paola, Rizzo, Aroldo, Sciacca, Elisabetta, Pillitteri, Irene, Vella, Veronica, Belfiore, Antonino, Bongiorno, Maria Rita, Pistone, Giuseppe, Memeo, Lorenzo, Colarossi, Lorenzo, Giuffrida, Dario, Colarossi, Cristina, Vigneri, Paolo, Todaro, Matilde, and Stassi, Giorgio

Published
2023
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2. Update on the Management of Pediatric Psoriasis: An Italian Consensus

Author

Peris, Ketty, Fortina, Anna Belloni, Bianchi, Luca, Fabbrocini, Gabriella, Gisondi, Paolo, Balato, Anna, Bardazzi, Federico, Bernardini, Nicoletta, Bonamonte, Domenico, Bongiorno, Maria Rita, Buligan, Cinzia, Cusano, Francesco, Del Giudice, Maria Beatrice De Felici, El Hachem, May, Fargnoli, Maria Concetta, Gualdi, Giulio, Guarneri, Claudio, Hansel, Katharina, Malara, Giovanna, Mazzatenta, Carlo, Micali, Giuseppe, Narcisi, Alessandra, Neri, Iria, Oranges, Teresa, Panzone, Michele, Parodi, Aurora, Restano, Lucia, Simonetti, Oriana, Venturini, Marina, and Di Lernia, Vito

Published
2022
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4. Effective targeting of breast cancer stem cells by combined inhibition of Sam68 and Rad51

Author

Turdo, Alice, Gaggianesi, Miriam, Di Franco, Simone, Veschi, Veronica, D’Accardo, Caterina, Porcelli, Gaetana, Lo Iacono, Melania, Pillitteri, Irene, Verona, Francesco, Militello, Gabriella, Zippo, Alessio, Poli, Vittoria, Fagnocchi, Luca, Beyes, Sven, Stella, Stefania, Lattanzio, Rossano, Faldetta, Naida, Lentini, Vincenzo L., Porcasi, Rossana, Pistone, Giuseppe, Bongiorno, Maria Rita, Stassi, Giorgio, De Maria, Ruggero, and Todaro, Matilde

Published
2022
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6. Guidelines How to Integrate Surgery and Targeted Therapy with Biologics for the Treatment of Hidradenitis Suppurativa: Delphi Consensus Statements from an Italian Expert Panel.

Author

Offidani, Annamaria, Marzano, Angelo Valerio, Peris, Ketty, Molinelli, Elisa, Bettoli, Vincenzo, Magnoni, Cristina, Vaienti, Luca, Pappagallo, Giovanni, Amerio, Paolo, Atzori, Laura, Balato, Anna, Bianchi, Luca, Bongiorno, Maria Rita, Contedini, Federico, Dapavo, Paolo, Di Benedetto, Giovanni, Dini, Valentina, Donini, Massimo, Fabbrocini, Gabriella, and Fania, Luca

Subjects
HIDRADENITIS suppurativa, SURGICAL excision, ADVERSE health care events, DELPHI method, THERAPEUTICS, BIOTHERAPY
Abstract

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by recurrent and painful nodules and abscesses in intertriginous skin areas, which can progress to sinus tract formation, tissue destruction, and scarring. HS is highly debilitating and severely impairs the psychological well-being and quality of life of patients. The therapeutic approach to HS is based on medical therapy and surgery. First-line medical therapy includes topical antibiotics, systemic antibiotics, and biologics. Main surgical procedures include deroofing, local excision, and wide local excision. Despite the availability of multiple therapeutic options, the rates of disease recurrence and progression continue to be high. In recent years, the possibility of combining biologic therapy and surgery has raised considerable interest. In a clinical trial, the perioperative use of adalimumab has been associated with greater response rates and improved inflammatory load and pain, with no increased risk of postoperative infectious complications. However, several practical aspects of combined biologic therapy and surgery are poorly defined. In June 2022, nine Italian HS experts convened to address issues related to the integration of biologic therapy and surgery in clinical practice. To this purpose, the experts identified 10 areas of interest based on published evidence and personal experience: (1) patient profiling (diagnostic criteria, disease severity classification, assessment of response to treatment, patient-reported outcomes, comorbidities); (2) tailoring surgery to HS characteristics; (3) wide local excision; (4) presurgery biologic treatment; (5) concomitant biologic and surgical treatments; (6) pre- and postsurgery management; (7) antibiotic systemic therapy; (8) biologic therapy after radical surgery; (9) management of adverse events to biologics; and (10) management of postoperative infectious complications. Consensus between experts was reached using the Estimate-Talk-Estimate method (Delphi Method). The statements were subsequently presented to a panel of 27 HS experts from across Italy, and their agreement was assessed using the UCLA Appropriateness Method. This article presents and discusses the consensus statements. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Patients Withdrawing Dupilumab Monotherapy for COVID-19–Related Reasons Showed Similar Disease Course Compared With Patients Continuing Dupilumab Therapy

Author

Chiricozzi, Andrea, Di Nardo, Lucia, Talamonti, Marina, Galluzzo, Marco, De Simone, Clara, Fabbrocini, Gabriella, Marzano, Angelo Valerio, Girolomoni, Giampiero, Offidani, Annamaria, Rossi, Maria Teresa, Bianchi, Luca, Cristaudo, Antonio, Fierro, Maria Teresa, Stingeni, Luca, Pellacani, Giovanni, Argenziano, Giuseppe, Patrizi, Annalisa, Pigatto, Paolo, Romanelli, Marco, Savoia, Paola, Rubegni, Pietro, Foti, Caterina, Milanesi, Nicola, Belloni Fortina, Anna, Bongiorno, Maria Rita, Grieco, Teresa, Di Nuzzo, Sergio, Fargnoli, Maria Concetta, Carugno, Andrea, Motolese, Alberico, Rongioletti, Franco, Amerio, Paolo, Balestri, Riccardo, Potenza, Concetta, Micali, Giuseppe, Patruno, Cataldo, Zalaudek, Iris, Lombardo, Maurizio, Feliciani, Claudio, Antonelli, Flaminia, Ferrucci, Silvia Mariel, Guarneri, Fabrizio, and Peris, Ketty

Published
2021
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8. Patients Withdrawing Dupilumab Monotherapy for COVID-19–Related Reasons Showed Similar Disease Course Compared With Patients Continuing Dupilumab Therapy

Author

Chiricozzi, Andrea, Di Nardo, Lucia, Talamonti, Marina, Galluzzo, Marco, De Simone, Clara, Fabbrocini, Gabriella, Marzano, Angelo Valerio, Girolomoni, Giampiero, Offidani, Annamaria, Rossi, Maria Teresa, Bianchi, Luca, Cristaudo, Antonio, Fierro, Maria Teresa, Stingeni, Luca, Pellacani, Giovanni, Argenziano, Giuseppe, Patrizi, Annalisa, Pigatto, Paolo, Romanelli, Marco, Savoia, Paola, Rubegni, Pietro, Foti, Caterina, Milanesi, Nicola, Belloni Fortina, Anna, Bongiorno, Maria Rita, Grieco, Teresa, Di Nuzzo, Sergio, Fargnoli, Maria Concetta, Carugno, Andrea, Motolese, Alberico, Rongioletti, Franco, Amerio, Paolo, Balestri, Riccardo, Potenza, Concetta, Micali, Giuseppe, Patruno, Cataldo, Zalaudek, Iris, Lombardo, Maurizio, Feliciani, Claudio, Antonelli, Flaminia, Ferrucci, Silvia Mariel, Guarneri, Fabrizio, and Peris, Ketty

Published
2022
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9. Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery

Author

Di Franco, Simone, Bianca, Paola, Sardina, Davide Stefano, Turdo, Alice, Gaggianesi, Miriam, Veschi, Veronica, Nicotra, Annalisa, Mangiapane, Laura Rosa, Lo Iacono, Melania, Pillitteri, Irene, van Hooff, Sander, Martorana, Federica, Motta, Gianmarco, Gulotta, Eliana, Lentini, Vincenzo Luca, Martorana, Emanuele, Fiori, Micol Eleonora, Vieni, Salvatore, Bongiorno, Maria Rita, Giannone, Giorgio, Giuffrida, Dario, Memeo, Lorenzo, Colarossi, Lorenzo, Mare, Marzia, Vigneri, Paolo, Todaro, Matilde, De Maria, Ruggero, Medema, Jan Paul, and Stassi, Giorgio

Published
2021
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10. Burden of Disease in Real-Life Setting of Patients With Atopic Dermatitis: Italian Data From the MEASURE-AD Study

Author

Argenziano, Giuseppe, primary, Mercuri, Santo Raffaele, additional, Savoia, Paola, additional, Amerio, Paolo, additional, Fortina, Anna Belloni, additional, Bongiorno, Maria Rita, additional, De Felici Del Giudice, Maria Beatrice, additional, Parodi, Aurora, additional, Pimpinelli, Nicola, additional, Stingeni, Luca, additional, Ortoncelli, Michela, additional, Stinco, Giuseppe, additional, Gualberti, Giuliana, additional, Levi, Anna, additional, Scuderi, Valeria, additional, Bianchi, Luca, additional, and Malara, Giovanna, additional

Published
2024
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11. Targeting chemoresistant colorectal cancer via systemic administration of a BMP7 variant

Author

Veschi, Veronica, Mangiapane, Laura R., Nicotra, Annalisa, Di Franco, Simone, Scavo, Emanuela, Apuzzo, Tiziana, Sardina, Davide S., Fiori, Micol, Benfante, Antonina, Colorito, Maria L., Cocorullo, Gianfranco, Giuliante, Felice, Cipolla, Calogero, Pistone, Giuseppe, Bongiorno, Maria Rita, Rizzo, Aroldo, Tate, Courtney M., Wu, Xiaohua, Rowlinson, Scott, Stancato, Louis F., Todaro, Matilde, De Maria, Ruggero, and Stassi, Giorgio

Published
2020
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12. The GENDER ATTENTION Observational Study: Gender and Hormonal Status Differences in the Incidence of Adverse Events During Cyclosporine Treatment in Psoriatic Patients

Author

Colombo, Delia, Banfi, Giuseppe, Cassano, Nicoletta, Graziottin, Alessandra, Vena, Gino Antonio, Fiori, Giovanni Gualberto, Zagni, Emanuela, Stingeni, Luca, Chimenti, Sergio, Berardesca, Enzo, Micali, Giuseppe, Albertini, Giuseppe, De Simone, Clara, Bellia, Gilberto, Amato, Salvatore, Ayala, Fabio, Bardazzi, Ferderico, Bernengo, Maria Grazia, Bongiorno, Maria Rita, Borroni, Giovanni, Calvieri, Stefano, Pinton, Piergiacomo Calzavara, Cannarozzo, Calcedonio, Cannavò, Serafinella Patrizia, Cattaneo, Angelo, Ceschini, Rossella, Colombo, Enrico, Congedo, Maurizio, Cusano, Francesco, De Pità, Ornella, Di Nuzzo, Sergio, Donadio, Dario, Donelli, Stefano, Filotico, Raffaele, Flori, Maria Laura, Germino, Maurizio, Girolomoni, Giampiero, Kokelj, Franco, Lanzoni, Anna, Lembo, Giuseppe, Locatelli, Andrea, Magnoni, Cristina, Marconi, Marco, Motolese, Alberico, Papini, Manuela, Parodi, Aurora, Pau, Monica, Peris, Ketty, Piaserico, Stefano, Piccirillo, Angelo, Potenza, Concetta, Ricotti, Giuseppe, Sedona, Patrizio, Stinco, Giuseppe, Valenti, Giancarlo, Fornasa, Cleto Veller, Zichichi, Leonardo, Ori, Alessandra, Amici, Christian, Zullo, Alessandro, Simoni, Lucia, Lanci, Nicole, Longagnani, Chiara, Sala, Saide, Trevisan, Francesca, Magri, Giovanna, and On behalf of the GENDER ATTENTION study group

Published
2017
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13. Italian Euromelanoma Day Screening Campaign (2005–2007) and the planning of melanoma screening strategies

Author

Seidenari, Stefania, Benati, Elisa, Ponti, Giovanni, Borsari, Stefania, Ferrari, Chiara, Albertini, Giuseppe, Altomare, Gianfranco, Arcangeli, Fabio, Aste, Nicola, Bernengo, Maria Grazia, Bongiorno, Maria Rita, Borroni, Giovanni, Calvieri, Stefano, Chimenti, Sergio, Cusano, Francesco, Fracchiolla, Claudio, Gaddoni, Giuseppe, Girolomoni, Giampiero, Guarneri, Biagio, Lanzoni, Anna, Lombardi, Mara, Lotti, Torello, Mariotti, Antonio, Marsili, Franco, Micali, Giuseppe, Parodi, Aurora, Peris, Ketty, Peserico, Andrea, Quaglino, Pietro, Santini, Marcello, Schiavon, Sergio, Tonino, Camillo, Trevisan, Giusto, Tribuzi, Paola, Valentini, Paolo, Vena, Gino A., and Virgili, Annarosa

Published
2012

16. Characteristic of chronic plaque psoriasis patients treated with biologics in Italy during the COVID-19 pandemic. risk analysis from the PSO-BIO-COVID observational study

Author

Talamonti, Marina, Galluzzo, Marco, Chiricozzi, Andrea, Quaglino, Pietro, Fabbrocini, Gabriella, Gisondi, Paolo, Marzano, Angelo Valerio, Potenza, Concetta, Conti, Andrea, Parodi, Aurora, Piaserico, Stefano, Bardazzi, Federico, Argenziano, Giuseppe, Rongioletti, Franco, Stingeni, Luca, Micali, Giuseppe, Loconsole, Francesco, Rossi, Maria Teresa, Bongiorno, Maria Rita, Feliciani, Claudio, Rubegni, Pietro, Amerio, Paolo, Fargnoli, Maria Concetta, Pigatto, Paolo, Savoia, Paola, Nisticò, Steven Paul, Giustini, Sandra, Carugno, Andrea, Cannavo', Serafinella Patrizia, Rech, Giulia, Prignano, Francesca, Offidani, Annamaria, Lombardo, Maurizio, Zalaudek, Iris, Bianchi, Luca, Peris, Ketty, PSO-BIO-COVID study group, Balestri R, Bernardini N, Belloni Fortini A, Burlando M, Caldarola G, Campione E, Cattaneo A, Dapavo P, Dastoli S, De Simone C, Di Nuzzo S, Diotallevi F, Fierro MT, Franchi C, Esposito M, Foti C, Gambini DM, Gambardella A, Girolomoni G, Giunta A, Guarneri C, Gualdi G, Hansel K, Megna M, Mugheddu C, Musumeci ML, Patrizi A, Pellacani G, Richetta AG, Rosi E, Sacchelli L, Tiberio R, Tilotta G, Trovato E, Venturini M, Vezzoni R, Talamonti, M., Galluzzo, M., Chiricozzi, A., Quaglino, P., Fabbrocini, G., Gisondi, P., Marzano, A. V., Potenza, C., Conti, A., Parodi, A., Piaserico, S., Bardazzi, F., Argenziano, G., Rongioletti, F., Stingeni, L., Micali, G., Loconsole, F., Rossi, M. T., Bongiorno, M. R., Feliciani, C., Rubegni, P., Amerio, P., Fargnoli, M. C., Pigatto, P., Savoia, P., Nistico, S. P., Giustini, S., Carugno, A., Cannavo', S. P., Rech, G., Prignano, F., Offidani, A., Lombardo, M., Zalaudek, I., Bianchi, L., Peris, K., Talamonti, M, Galluzzo, M, Chiricozzi, A, Quaglino, P, Fabbrocini, G, Gisondi, P, Marzano, A, Potenza, C, Conti, A, Parodi, A, Piaserico, S, Bardazzi, F, Argenziano, G, Rongioletti, F, Stingeni, L, Micali, G, Loconsole, F, Rossi, M, Bongiorno, M, Feliciani, C, Rubegni, P, Amerio, P, Fargnoli, M, Pigatto, P, Savoia, P, Nisticò, S, Giustini, S, Carugno, A, Cannavo’, S, Rech, G, Prignano, F, Offidani, A, Lombardo, M, Zalaudek, I, Bianchi, L, Peris, K, Talamonti, Marina, Galluzzo, Marco, Chiricozzi, Andrea, Quaglino, Pietro, Fabbrocini, Gabriella, Gisondi, Paolo, Marzano, Angelo Valerio, Potenza, Concetta, Conti, Andrea, Parodi, Aurora, Piaserico, Stefano, Bardazzi, Federico, Argenziano, Giuseppe, Rongioletti, Franco, Stingeni, Luca, Micali, Giuseppe, Loconsole, Francesco, Rossi, Maria Teresa, Bongiorno, Maria Rita, Feliciani, Claudio, Rubegni, Pietro, Amerio, Paolo, Fargnoli, Maria Concetta, Pigatto, Paolo, Savoia, Paola, Nisticò, Steven Paul, Giustini, Sandra, Carugno, Andrea, Cannavo', Serafinella Patrizia, Rech, Giulia, Prignano, Francesca, Offidani, Annamaria, Lombardo, Maurizio, Zalaudek, Iri, Bianchi, Luca, Peris, Ketty, PSO-BIO-COVID study, Group, Balestri, R, Bernardini, N, Belloni Fortini, A, Burlando, M, Caldarola, G, Campione, E, Cattaneo, A, Dapavo, P, Dastoli, S, De Simone, C, Di Nuzzo, S, Diotallevi, F, Fierro, Mt, Franchi, C, Esposito, M, Foti, C, Gambini, Dm, Gambardella, A, Girolomoni, G, Giunta, A, Guarneri, C, Gualdi, G, Hansel, K, Megna, M, Mugheddu, C, Musumeci, Ml, Patrizi, A, Pellacani, G, Richetta, Ag, Rosi, E, Sacchelli, L, Tiberio, R, Tilotta, G, Trovato, E, Venturini, M, Vezzoni, R, Talamonti M., Galluzzo M., Chiricozzi A., Quaglino P., Fabbrocini G., Gisondi P., Marzano A.V., Potenza C., Conti A., Parodi A., Piaserico S., Bardazzi F., Argenziano G., Rongioletti F., Stingeni L., Micali G., Loconsole F., Rossi M.T., Bongiorno M.R., Feliciani C., Rubegni P., Amerio P., Fargnoli M.C., Pigatto P., Savoia P., Nistico S.P., Giustini S., Carugno A., Cannavo' S.P., Rech G., Prignano F., Offidani A., Lombardo M., Zalaudek I., Bianchi L., and Peris K.

Subjects
0301 basic medicine, Male, Clinical Biochemistry, Disease, Cohort Studies, 0302 clinical medicine, Drug Discovery, Receptors, 80 and over, Medicine, Aged, 80 and over, education.field_of_study, Incidence (epidemiology), Incidence, Interleukin-17, psoriasis, Middle Aged, dermatology, sars-CoV-2, Italy, biological therapy, 030220 oncology & carcinogenesis, Cohort, Biological Product, COVID-19, Female, Settore MED/35 - MALATTIE CUTANEE E VENEREE, Adult, Aged, Biological Products, Biological Therapy, Chronic Disease, Humans, Pandemics, Psoriasis, Receptors, Interleukin, Risk Assessment, Tumor Necrosis Factor-alpha, Young Adult, Cohort study, Human, medicine.medical_specialty, Population, 03 medical and health sciences, Settore MED/35, Internal medicine, education, Pharmacology, Psoriasi, Pandemic, business.industry, Biological product, Interleukin, medicine.disease, Clinical trial, 030104 developmental biology, SARS-CoV-2, Cohort Studie, business
Abstract

Background The susceptibility of patients with chronic plaque psoriasis and the risks or benefits related to the use of biological therapies for COVID-19 are unknown. Few data about prevalence, clinical course and outcomes of COVID-19 among psoriatic patients were reported. The aims of this study were 1) to assess the prevalence and severity of COVID-19 in psoriatic patients treated with biologic agents during the first phase of the emergency (22 February to 22 April 2020) in Italy, and 2) to report the clinical outcomes of patients who have been exposed to individuals with confirmed SARS-CoV-2 infection. Methods Patients with moderate-to-severe chronic plaque psoriasis, aged ≥18 years and undergoing treatment with biologic agents as of 22 February 2020, were eligible to be included in PSO-BIO-COVID study. Demographic and clinical characteristics of patients using any biologic for psoriasis treatment between 22 February and 22 April 2020 were registered. For all confirmed or suspected cases of COVID-19, data about concomitant disease, ongoing therapies, and comorbidities were also reported. Results A total of 12,807 psoriatic patients were included in the PSO-BIO-COVID study. In this cohort twenty-six patients (0.2%) had a swab confirmation of SARS-CoV-2 infection. Eleven patients required hospitalization and two died. 125 of 12807 patients (1.0%) with exposure to a patient with COVID-19 under quarantine or active health surveillance, were reported. Conclusion The incidence of COVID-19 observed in our cohort of psoriatic patients (0.2%) is similar to that seen in the general population (0.31%) in Italy. However, the course of the disease was mild in most patients. Biological therapies may likely lessen "cytokine storm" of COVID-19, which sometimes lead to multiple organ failure, ARDS, and death.

Published
2021

17. Management of patients with atopic dermatitis undergoing systemic therapy during COVID-19 pandemic in Italy: Data from the DA-COVID-19 registry

Author

Chiricozzi, Andrea, Talamonti, Marina, De Simone, Clara, Galluzzo, Marco, Gori, Niccolò, Fabbrocini, Gabriella, Marzano, Angelo Valerio, Girolomoni, Giampiero, Offidani, Annamaria, Rossi, Maria Teresa, Bianchi, Luca, Cristaudo, Antonio, Fierro, Maria Teresa, Stingeni, Luca, Pellacani, Giovanni, Argenziano, Giuseppe, Patrizi, Annalisa, Pigatto, Paolo, Romanelli, Marco, Savoia, Paola, Rubegni, Pietro, Foti, Caterina, Milanesi, Nicola, Belloni Fortina, Anna, Bongiorno, Maria Rita, Grieco, Teresa, Di Nuzzo, Sergio, Fargnoli, Maria Concetta, Carugno, Andrea, Motolese, Alberico, Rongioletti, Franco, Amerio, Paolo, Balestri, Riccardo, Potenza, Concetta, Micali, Giuseppe, Patruno, Cataldo, Zalaudek, Iris, Lombardo, Maurizio, Feliciani, Claudio, Di Nardo, Lucia, Guarneri, Fabrizio, Peris, Ketty, Caldarola, Giacomo, Silvaggio, Dionisio, Dattola, Annunziata, Napolitano, Maddalena, Ferrucci, Silvia Mariel, Dal Bello, Giacomo, Bianchelli, Tommaso, Rovati, Chiara, Pigliacelli, Flavia, Ortoncelli, Michela, Hansel, Katharina, Calabrese, Giulia, Loi, Camilla, Iannone, Michela, Veronese, Federica, Romita, Paolo, Tronconi, Greta, Caroppo, Francesca, Tilotta, Giovanna, Sernicola, Alvise, Esposito, Maria, Raponi, Francesca, Gualdi, Giulio, Rech, Giulia, Musumeci, Maria Letizia, Nisticò, Steven Paul, Campitiello, Alessio, Bonzano, Laura, Piras, Viviana, Chiricozzi, A., Talamonti, M., De Simone, C., Galluzzo, M., Gori, N., Fabbrocini, G., Marzano, A. V., Girolomoni, G., Offidani, A., Rossi, M. T., Bianchi, L., Cristaudo, A., Fierro, M. T., Stingeni, L., Pellacani, G., Argenziano, G., Patrizi, A., Pigatto, P., Romanelli, M., Savoia, P., Rubegni, P., Foti, C., Milanesi, N., Belloni Fortina, A., Bongiorno, M. R., Grieco, T., Di Nuzzo, S., Fargnoli, M. C., Carugno, A., Motolese, A., Rongioletti, F., Amerio, P., Balestri, R., Potenza, C., Micali, G., Patruno, C., Zalaudek, I., Lombardo, M., Feliciani, C., Di Nardo, L., Guarneri, F., Peris, K., Caldarola, G., Silvaggio, D., Dattola, A., Napolitano, M., Ferrucci, S. M., Dal Bello, G., Bianchelli, T., Rovati, C., Pigliacelli, F., Ortoncelli, M., Hansel, K., Calabrese, G., Loi, C., Iannone, M., Veronese, F., Romita, P., Tronconi, G., Caroppo, F., Tilotta, G., Sernicola, A., Esposito, M., Raponi, F., Gualdi, G., Rech, G., Musumeci, M. L., Nistico, S. P., Campitiello, A., Bonzano, L., Piras, V., Chiricozzi, Andrea, Talamonti, Marina, De Simone, Clara, Galluzzo, Marco, Gori, Niccolò, Fabbrocini, Gabriella, Marzano, Angelo Valerio, Girolomoni, Giampiero, Offidani, Annamaria, Rossi, Maria Teresa, Bianchi, Luca, Cristaudo, Antonio, Fierro, Maria Teresa, Stingeni, Luca, Pellacani, Giovanni, Argenziano, Giuseppe, Patrizi, Annalisa, Pigatto, Paolo, Romanelli, Marco, Savoia, Paola, Rubegni, Pietro, Foti, Caterina, Milanesi, Nicola, Belloni Fortina, Anna, Bongiorno, Maria Rita, Grieco, Teresa, Di Nuzzo, Sergio, Fargnoli, Maria Concetta, Carugno, Andrea, Motolese, Alberico, Rongioletti, Franco, Amerio, Paolo, Balestri, Riccardo, Potenza, Concetta, Micali, Giuseppe, Patruno, Cataldo, Zalaudek, Iri, Lombardo, Maurizio, Feliciani, Claudio, Di Nardo, Lucia, Guarneri, Fabrizio, Peris, Ketty, Caldarola, Giacomo, Silvaggio, Dionisio, Dattola, Annunziata, Napolitano, Maddalena, Ferrucci, Silvia Mariel, Dal Bello, Giacomo, Bianchelli, Tommaso, Rovati, Chiara, Pigliacelli, Flavia, Ortoncelli, Michela, Hansel, Katharina, Calabrese, Giulia, Loi, Camilla, Iannone, Michela, Veronese, Federica, Romita, Paolo, Tronconi, Greta, Caroppo, Francesca, Tilotta, Giovanna, Sernicola, Alvise, Esposito, Maria, Raponi, Francesca, Gualdi, Giulio, Rech, Giulia, Musumeci, Maria Letizia, Nisticò, Steven Paul, Campitiello, Alessio, Bonzano, Laura, Piras, Viviana, Chiricozzi, A, Talamonti, M, De Simone, C, Galluzzo, M, Gori, N, Fabbrocini, G, Marzano, A, Girolomoni, G, Offidani, A, Rossi, M, Bianchi, L, Cristaudo, A, Fierro, M, Stingeni, L, Pellacani, G, Argenziano, G, Patrizi, A, Pigatto, P, Romanelli, M, Savoia, P, Rubegni, P, Foti, C, Milanesi, N, Belloni Fortina, A, Bongiorno, M, Grieco, T, Di Nuzzo, S, Fargnoli, M, Carugno, A, Motolese, A, Rongioletti, F, Amerio, P, Balestri, R, Potenza, C, Micali, G, Patruno, C, Zalaudek, I, Lombardo, M, Feliciani, C, Di Nardo, L, Guarneri, F, Peris, K, Caldarola, G, Silvaggio, D, Dattola, A, Napolitano, M, Ferrucci, S, Dal Bello, G, Bianchelli, T, Rovati, C, Pigliacelli, F, Ortoncelli, M, Hansel, K, Calabrese, G, Loi, C, Iannone, M, Veronese, F, Romita, P, Tronconi, G, Caroppo, F, Tilotta, G, Sernicola, A, Esposito, M, Raponi, F, Gualdi, G, Rech, G, Musumeci, M, Nistico, S, Campitiello, A, Bonzano, L, and Piras, V

Subjects
Registrie, 0301 basic medicine, Dermatitis, Systemic therapy, 0302 clinical medicine, Pandemic, Immunology and Allergy, Medicine, Registries, atopic dermatitis, COVID, SARS‐ CoV, treatment, SARS-CoV, Atopic dermatitis, Dupilumab, Italy, Original Article, Settore MED/35 - MALATTIE CUTANEE E VENEREE, Human, atopic dermatiti, Adult, medicine.medical_specialty, Teledermatology, SARS‐CoV, atopic dermatitis, treatment, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Immunology, Communicable Disease Control, Humans, Pandemics, SARS-CoV-2, COVID-19, Dermatitis, Atopic, Atopic, 03 medical and health sciences, Settore MED/35, Disease severity, Internal medicine, business.industry, medicine.disease, 030104 developmental biology, 030228 respiratory system, atopic dermatitis, COVID, SARS-CoV, business
Abstract

Background Few and small studies have described the management of immunomodulant/immunosuppressive therapies or phototherapy in atopic dermatitis (AD) patients during coronavirus disease 2019 (COVID‐19) pandemic. Methods A national registry, named DA‐COVID‐19 and involving 35 Italian dermatology units, was established in order to evaluate the impact of COVID‐19 pandemic on the management of adult AD patients treated with systemic immunomodulant/immunosuppressive medications or phototherapy. Demographic and clinical data were obtained at different timepoints by teledermatology during COVID‐19 pandemic, when regular visits were not allowed due to sanitary restrictions. Disease severity was assessed by both physician‐ and patient‐reported assessment scores evaluating itch intensity, sleep disturbances, and AD severity. Results A total of 1831 patients were included, with 1580/1831 (86.3%) continuing therapy during pandemic. Most patients were treated with dupilumab (86.1%, 1576/1831) that was interrupted in only 9.9% (156/1576) of cases, while systemic immunosuppressive compounds were more frequently withdrawn. Treatment interruption was due to decision of the patient, general practitioner, or dermatologist in 39.9% (114/286), 5.6% (16/286), and 30.1% (86/286) of cases, respectively. Fear of increased susceptibility to SARS‐CoV‐2 infection (24.8%, 71/286) was one of the main causes of interruption. Sixteen patients (0.9%) resulted positive to SARS‐CoV‐2 infection; 3 of them (0.2%) were hospitalized but no cases of COVID‐related death occurred. Conclusions Most AD patients continued systemic treatments during COVID pandemic and lockdown period, without high impact on disease control, particularly dupilumab‐treated patients., Among 1831 studied AD patients, 86.1% were treated with dupilumab. Patients continuing therapy experienced a marked reduction of disease severity during pandemic. The causes of treatment interruption included: fear of increased susceptibility to SARS‐CoV‐2 infection (24.8%), occurrence of comorbidities (5.9%), age above 60 years (5.2%), SARS‐CoV‐2 infection (2.8%), close contact with SARS‐CoV‐2‐positive subject (2.4%), other reasons, for example, inability to maintain drug supply, non‐medical/unspecified causes (58.7%).

Published
2021

18. Dual Inhibition of Myc Transcription and PI3K Activity Effectively Targets Colorectal Cancer Stem Cells

Author

Gaggianesi, Miriam, primary, Mangiapane, Laura Rosa, additional, Modica, Chiara, additional, Pantina, Vincenzo Davide, additional, Porcelli, Gaetana, additional, Di Franco, Simone, additional, Lo Iacono, Melania, additional, D’Accardo, Caterina, additional, Verona, Francesco, additional, Pillitteri, Irene, additional, Turdo, Alice, additional, Veschi, Veronica, additional, Brancato, Ornella Roberta, additional, Muratore, Giampaolo, additional, Pistone, Giuseppe, additional, Bongiorno, Maria Rita, additional, Todaro, Matilde, additional, De Maria, Ruggero, additional, and Stassi, Giorgio, additional

Published
2022
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20. Targeting Phosphatases and Kinases: How to Checkmate Cancer

Author

Turdo, Alice, primary, D’Accardo, Caterina, additional, Glaviano, Antonino, additional, Porcelli, Gaetana, additional, Colarossi, Cristina, additional, Colarossi, Lorenzo, additional, Mare, Marzia, additional, Faldetta, Naida, additional, Modica, Chiara, additional, Pistone, Giuseppe, additional, Bongiorno, Maria Rita, additional, Todaro, Matilde, additional, and Stassi, Giorgio, additional

Published
2021
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21. Hidradenitis Suppurativa in a Large Cohort of Italian Patients: Evaluation of the Burden of Disease

Author

Fabbrocini, Gabriella, primary, Ruina, Giulia, additional, Giovanardi, Giulia, additional, Dini, Valentina, additional, Raone, Beatrice, additional, Venturini, Marina, additional, Caposiena Caro, Raffaele Dante, additional, Veraldi, Stefano, additional, Cannavò, Serafinella Patrizia, additional, Merlo, Giulia, additional, Bertoldi, Alberto Maria, additional, Fiorentini, Federica, additional, Molinelli, Elisa, additional, Atzori, Laura, additional, Bongiorno, Maria Rita, additional, Lo Re, Michele, additional, Skroza, Nevena, additional, Lasagni, Claudia, additional, Franchi, Chiara, additional, Ardigò, Marco, additional, Di Costanzo, Luisa, additional, Stingeni, Luca, additional, Amerio, Paolo, additional, Sanna, Federica, additional, Pescitelli, Leonardo, additional, Broganelli, Paolo, additional, De Cupis, Claudia, additional, Gualberti, Giuliana, additional, Saragaglia, Valeria, additional, and Argenziano, Giuseppe, additional

Published
2021
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22. Nobiletin and Xanthohumol Sensitize Colorectal Cancer Stem Cells to Standard Chemotherapy

Author

Turdo, Alice, primary, Glaviano, Antonino, additional, Pepe, Giacomo, additional, Calapà, Federica, additional, Raimondo, Stefania, additional, Fiori, Micol Eleonora, additional, Carbone, Daniela, additional, Basilicata, Manuela Giovanna, additional, Di Sarno, Veronica, additional, Ostacolo, Carmine, additional, Parrino, Barbara, additional, Cascioferro, Stella, additional, Pecoraro, Camilla, additional, Di Franco, Simone, additional, Bellavia, Diana, additional, Gaggianesi, Miriam, additional, Veschi, Veronica, additional, Lo Iacono, Melania, additional, Ganduscio, Gloria, additional, Pantina, Vincenzo Davide, additional, Mangiapane, Laura Rosa, additional, Bongiorno, Maria Rita, additional, Alessandro, Riccardo, additional, Todaro, Matilde, additional, De Maria, Ruggero, additional, Diana, Patrizia, additional, Campiglia, Pietro, additional, and Stassi, Giorgio, additional

Published
2021
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24. Messing Up the Cancer Stem Cell Chemoresistance Mechanisms Supported by Tumor Microenvironment

Author

Gaggianesi, Miriam, primary, Di Franco, Simone, additional, Pantina, Vincenzo Davide, additional, Porcelli, Gaetana, additional, D'Accardo, Caterina, additional, Verona, Francesco, additional, Veschi, Veronica, additional, Colarossi, Lorenzo, additional, Faldetta, Naida, additional, Pistone, Giuseppe, additional, Bongiorno, Maria Rita, additional, Todaro, Matilde, additional, and Stassi, Giorgio, additional

Published
2021
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26. PI3K-driven HER2 expression is a potential therapeutic target in colorectal cancer stem cells

Author

Mangiapane, Laura Rosa, Nicotra, Annalisa, Turdo, Alice, Gaggianesi, Miriam, Bianca, Paola, Di Franco, Simone, Sardina, Davide Stefano, Veschi, Veronica, Signore, Michele, Beyes, Sven, Fagnocchi, Luca, Fiori, Micol Eleonora, Bongiorno, Maria Rita, Lo Iacono, Melania, Pillitteri, Irene, Ganduscio, Gloria, Gulotta, Gaspare, Medema, Jan Paul, Zippo, Alessio, Todaro, Matilde, De Maria Marchiano, Ruggero, Stassi, Giorgio, De Maria, Ruggero (ORCID:0000-0003-2255-0583), Mangiapane, Laura Rosa, Nicotra, Annalisa, Turdo, Alice, Gaggianesi, Miriam, Bianca, Paola, Di Franco, Simone, Sardina, Davide Stefano, Veschi, Veronica, Signore, Michele, Beyes, Sven, Fagnocchi, Luca, Fiori, Micol Eleonora, Bongiorno, Maria Rita, Lo Iacono, Melania, Pillitteri, Irene, Ganduscio, Gloria, Gulotta, Gaspare, Medema, Jan Paul, Zippo, Alessio, Todaro, Matilde, De Maria Marchiano, Ruggero, Stassi, Giorgio, and De Maria, Ruggero (ORCID:0000-0003-2255-0583)

Abstract

Objective: Cancer stem cells are responsible for tumour spreading and relapse. Human epidermal growth factor receptor 2 (HER2) expression is a negative prognostic factor in colorectal cancer (CRC) and a potential target in tumours carrying the gene amplification. Our aim was to define the expression of HER2 in colorectal cancer stem cells (CR-CSCs) and its possible role as therapeutic target in CRC resistant to anti- epidermal growth factor receptor (EGFR) therapy. Design: A collection of primary sphere cell cultures obtained from 60 CRC specimens was used to generate CR-CSC mouse avatars to preclinically validate therapeutic options. We also made use of the ChIP-seq analysis for transcriptional evaluation of HER2 activation and global RNA-seq to identify the mechanisms underlying therapy resistance. Results: Here we show that in CD44v6-positive CR-CSCs, high HER2 expression levels are associated with an activation of the phosphatidylinositol 3-kinase (PI3K)/AKT pathway, which promotes the acetylation at the regulatory elements of the Erbb2 gene. HER2 targeting in combination with phosphatidylinositol 3-kinase (PI3K) and mitogen-activated protein kinase kinase (MEK) inhibitors induces CR-CSC death and regression of tumour xenografts, including those carrying Kras and Pik3ca mutation. Requirement for the triple targeting is due to the presence of cancer-associated fibroblasts, which release cytokines able to confer CR-CSC resistance to PI3K/AKT inhibitors. In contrast, targeting of PI3K/AKT as monotherapy is sufficient to kill liver-disseminating CR-CSCs in a model of adjuvant therapy. Conclusions: While PI3K targeting kills liver-colonising CR-CSCs, the concomitant inhibition of PI3K, HER2 and MEK is required to induce regression of tumours resistant to anti-EGFR therapies. These data may provide a rationale for designing clinical trials in the adjuvant and metastatic setting.

Published
2021

29. Hidradenitis Suppurativa in a Large Cohort of Italian Patients: Evaluation of the Burden of Disease.

Author

Fabbrocini, Gabriella, Ruina, Giulia, Giovanardi, Giulia, Dini, Valentina, Raone, Beatrice, Venturini, Marina, Caposiena Caro, Raffaele Dante, Veraldi, Stefano, Cannavò, Serafinella Patrizia, Merlo, Giulia, Bertoldi, Alberto Maria, Fiorentini, Federica, Molinelli, Elisa, Atzori, Laura, Bongiorno, Maria Rita, Lo Re, Michele, Skroza, Nevena, Lasagni, Claudia, Franchi, Chiara, and Ardigò, Marco

Subjects
HIDRADENITIS suppurativa, HAIR diseases, GROIN, LABOR productivity, HAIR follicles
Abstract

Background: Hidradenitis suppurativa (HS) is a chronic, inflammatory, recurrent, debilitating skin disease of the hair follicle that usually occurs after puberty with painful, deep-seated, inflamed nodules and sinus tracts in the apocrine gland-bearing areas of the body, most commonly the axillae and inguinal and anogenital regions, with a relevant impact on patients' quality of life (QoL). Objective: To evaluate how the burden of HS disease impacts on patient well-being and working activities in a large Italian population over a period of 9 months. Methods: A multicenter, prospective, epidemiologic cohort study was conducted in adult Italian patients with HS. HS severity was assessed through Hurley stage and HS Physician's Global Assessment (HS-PGA), clinical improvement by HS Clinical Response (HiSCR) and partial response, and disease burden through QoL questionnaires (HIDRAdisk, Skindex-16, Dermatology Life Quality Index [DLQI]), and Work Productivity and Activity Impairment – General Health (WPAI:GH). Results: A total of 308 patients (56.2% women; mean age 35.2 ± 12.9 years) were enrolled in 27 dermatologic clinics. Men were older (37.4 years vs. 33.5), more smoking addicted (74.1% vs. 60.1%), and alcohol consumer (34.1% vs. 13.9%), while more women were obese (34.10% vs. 22.22%). At baseline, most patients had a Hurley severity stage of 2 (43.9%), a moderate HS-PGA score (57.1%), and poor QoL (HIDRAdisk: 65.7 ± 23.3, Skindex-16: 60.3 ± 26.9, and DLQI: 10.8 ± 8.1). Patients with more severe disease showed worse QoL. Mean values for the variables related to HS severity decreased during the study period. The achievement of HiSCR and partial response increased during the study. Conclusion: This study offers insight into the disease burden of HS in an Italian population. Our results underline the impact of QoL evaluation, also with the use of the HIDRAdisk, in clinical routine as a support to validated severity clinical and instrumental indexes for a "360-degree" assessment of HS patient's burden of disease. [ABSTRACT FROM AUTHOR]

Published
2022
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30. Management of patients with atopic dermatitis undergoing systemic therapy during COVID-19 pandemic in Italy: data from the DA-COVID-19 registry Running title: AD management during COVID-19 pandemic

Author

Chiricozzi, Andrea, primary, Talamonti, Marina, additional, Simone, Clara De, additional, Galluzzo, Marco, additional, Gori, Niccolò, additional, Fabbrocini, Gabriella, additional, Marzano, Angelo Valerio, additional, Girolomoni, Giampiero, additional, Offidani, Annamaria, additional, Rossi, Maria Teresa, additional, Bianchi, Luca, additional, Cristaudo, Antonio, additional, Fierro, Maria Teresa, additional, Stingeni, Luca, additional, Pellacani, Giovanni, additional, Argenziano, Giuseppe, additional, Patrizi, Annalisa, additional, Pigatto, Paolo, additional, Romanelli, Marco, additional, Savoia, Paola, additional, Rubegni, Pietro, additional, Foti, Caterina, additional, Milanesi, Nicola, additional, Fortina, Anna Belloni, additional, Bongiorno, Maria Rita, additional, Grieco, Teresa, additional, Nuzzo, Sergio Di, additional, Fargnoli, Maria Concetta, additional, Carugno, Andrea, additional, Motolese, Alberico, additional, Rongioletti, Franco, additional, Amerio, Paolo, additional, Balestri, Riccardo, additional, Potenza, Concetta, additional, Micali, Giuseppe, additional, Patruno, Cataldo, additional, Zalaudek, Iris, additional, Lombardo, Maurizio, additional, Feliciani, Claudio, additional, Nardo, Lucia Di, additional, Guarneri, Fabrizio, additional, Peris, Ketty, additional, and Da-, Md ;, additional

Published
2021
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31. PI3K-driven HER2 expression is a potential therapeutic target in colorectal cancer stem cells

Author

Mangiapane, Laura Rosa, primary, Nicotra, Annalisa, additional, Turdo, Alice, additional, Gaggianesi, Miriam, additional, Bianca, Paola, additional, Di Franco, Simone, additional, Sardina, Davide Stefano, additional, Veschi, Veronica, additional, Signore, Michele, additional, Beyes, Sven, additional, Fagnocchi, Luca, additional, Fiori, Micol Eleonora, additional, Bongiorno, Maria Rita, additional, Lo Iacono, Melania, additional, Pillitteri, Irene, additional, Ganduscio, Gloria, additional, Gulotta, Gaspare, additional, Medema, Jan Paul, additional, Zippo, Alessio, additional, Todaro, Matilde, additional, De Maria, Ruggero, additional, and Stassi, Giorgio, additional

Published
2021
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34. Management of patients with atopic dermatitis undergoing systemic therapy during COVID-19 pandemic in Italy: data from the DA-COVID-19 registry

Author

Chiricozzi, Andrea, primary, Talamonti, Marina, additional, Simone, Clara De, additional, Galluzzo, Marco, additional, Gori, Niccolò, additional, Fabbrocini, Gabriella, additional, Marzano, Angelo, additional, Girolomoni, Giampiero, additional, Offidani, Anna Maria, additional, Rossi, Maria Teresa, additional, Bianchi, Luca, additional, Cristaudo, Antonio, additional, Fierro, Maria Teresa, additional, Stingeni, Luca, additional, Pellacani, Giovanni, additional, Argenziano, Giovanni, additional, Patrizi, Annalisa, additional, Pigatto, Paolo, additional, Romanelli, Marco, additional, Savoia, Paola, additional, Rubegni, Pietro, additional, Foti, Caterina, additional, Milanesi, Nicola, additional, Fortina, Anna Belloni, additional, Bongiorno, Maria Rita, additional, Grieco, Teresa, additional, Nuzzo, Sergio Di, additional, Fargnoli, Maria Concetta, additional, Carugno, Andrea, additional, Motolese, Alberico, additional, Rongioletti, Franco, additional, Amerio, Paolo, additional, Balestri, Riccardo, additional, Potenza, Concetta, additional, Micali, Giuseppe, additional, Patruno, Cataldo, additional, Zalaudek, Iris, additional, Lombardo, Maurizio, additional, Feliciani, Claudio, additional, Guarneri, Fabrizio, additional, and Peris, Ketty, additional

Published
2020
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41. PI3K-driven HER2 expression is a potential therapeutic target in colorectal cancer stem cells.

Author

Mangiapane, Laura Rosa, Nicotra, Annalisa, Turdo, Alice, Gaggianesi, Miriam, Bianca, Paola, Di Franco, Simone, Sardina, Davide Stefano, Veschi, Veronica, Signore, Michele, Beyes, Sven, Fagnocchi, Luca, Stassi, Giorgio, Fiori, Micol Eleonora, Bongiorno, Maria Rita, Lo Iacono, Melania, Pillitteri, Irene, Ganduscio, Gloria, Gulotta, Gaspare, Medema, Jan Paul, and Zippo, Alessio

Subjects
COLORECTAL cancer, CANCER stem cells, DRUG target, PROGNOSIS, MEDICAL research, MELANOMA, CANCER cell growth
Published
2022
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42. Nodular morphea keloidal type: A rare case with paradigmatic histopathology significantly accompanied by a flawless surgical scar.

Author

Castelli, Elena, Orlando, Elisabetta, Pardo, Nicola, Turdo, Alice, Pistone, Giuseppe, and Bongiorno, Maria Rita

Subjects
HYPERTROPHIC scars, KELOIDS, SCARS, HISTOPATHOLOGY, SYSTEMIC scleroderma, BLOOD cell count
Abstract

Here we report a case of keloidal morphea with multiple histopathologically typical nodules in the absence of clinical or laboratory signs of scleroderma, whose clinical diagnosis was suggested by a concomitant normally cicatrized scar from quadrantectomy. Keywords: bland surgical scar; nodular/keloidal morphea; unusual immunohistochemical features EN bland surgical scar nodular/keloidal morphea unusual immunohistochemical features 1329 1334 6 10/25/21 20211101 NES 211101 INTRODUCTION Nodular morphea is a rare variant of localized scleroderma, clinically and histopathologically characterized by cutaneous nodules or plaques associated or superimposed to the flat lesions of classic morphea.1-3 Accordingly, the association of such outgrowths with systemic sclerosis is designated as nodular scleroderma.4-6 Sometimes these lesions appear as firm, erythematous and irregularly curvy plaques resembling keloids or hypertrophic scars, thus characterizing keloidal morphea or keloidal scleroderma.7-10 These mystifying features can make the diagnosis challenging, especially in the absence of a well-documented medical history. B, Felt-like texture of the papillary dermis, twining of the collagen bundles in the superficial reticular dermis, wide weave of broad hyaline and hypereosinophilic (keloidal) collagen bundles in mid dermis, intermingled with roughly spindled cells (H&E, X100). [Extracted from the article]

Published
2021
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44. Targeting chemoresistant colorectal cancer via systemic administration of a BMP7 variant

Author

Veschi, Veronica, primary, Mangiapane, Laura R., additional, Nicotra, Annalisa, additional, Di Franco, Simone, additional, Scavo, Emanuela, additional, Apuzzo, Tiziana, additional, Sardina, Davide S., additional, Fiori, Micol, additional, Benfante, Antonina, additional, Colorito, Maria L., additional, Cocorullo, Gianfranco, additional, Giuliante, Felice, additional, Cipolla, Calogero, additional, Pistone, Giuseppe, additional, Bongiorno, Maria Rita, additional, Rizzo, Aroldo, additional, Tate, Courtney M., additional, Wu, Xiaohua, additional, Rowlinson, Scott, additional, Stancato, Louis F., additional, Todaro, Matilde, additional, De Maria, Ruggero, additional, and Stassi, Giorgio, additional

Published
2019
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46. Letter: psoriasiform eruption during vedolizumab therapy

Author

Garbo, Giuseppe Maria, primary, Renna, Sara, additional, Caputo, Valentina, additional, Orlando, Elisabetta, additional, Macaluso, Fabio Salvatore, additional, Orlando, Rosalba, additional, Bongiorno, Maria Rita, additional, and Orlando, Ambrogio, additional

Published
2019
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48. Suspected cutaneous leishmaniasis in a sample of Western Sicily residents: what correlation with occupation?

Author

VERSO, Maria Gabriella, Vitale, F., Castelli, G., Bruno, F., Migliazzo, A., BONGIORNO, Maria Rita, Santi, F., PISTONE, Giuseppe, Amodio, E., PICCIOTTO, Diego, Verso, M., Vitale, F., Castelli, G., Bruno, F., Migliazzo, A., Bongiorno, M., Santi, F., Pistone, G., Amodio, E., and Picciotto, D.

Subjects
Cutaneous leishmaniasis, Leishmania infantum, work-related leishmaniasis, climate change, Settore MED/44 - Medicina Del Lavoro, Cutaneous leishmaniasi, work-related leishmaniasi
Abstract

Background: Leishmaniasis is a widespread infectious disease, but there is not much information about its prevalence in high risk occupational categories. Objectives: Te aim of this study is to assess the prevalence of Leishmania immunological positivity in human skin tissues collected from subjects living in Western Sicily, with suspected cutaneous Leishmania infection, in order to explore the risk possibly related to occupation. Methods: 318 consecutive subjects (M/F ratio=1.0, mean age=40±25.4 years), attending the Dermatology Department of the University of Palermo Hospital from 2013 to 2015, without any previous history of Leishmania infection and performing various occupations, were included. Parasite isolation and PCR-RT test on skin scrapings were performed to evaluate the immunological status; all data were analyzed by the chi square test, comparing all positive results from the different provinces. Results: 81 (50.9%) out of 159 females and 79 (49.7%) out of 159 males were found PCR-RT positive to Leishmania infantum, with a higher risk in the Agrigento district (p

Published
2017

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