42 results on '"Ba, Luo"'
Search Results
2. Incidence and prognosis of olfactory and gustatory dysfunctions related to SARS‐CoV‐2 Omicron strain infection in mainland China: A national multicenter survey of 35,566 individuals
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Liu, Meng‐Fan, primary, Ma, Rui‐Xia, additional, Cao, Xian‐Bao, additional, Zhang, Hua, additional, Zhou, Shui‐Hong, additional, Jiang, Wei‐Hong, additional, Jiang, Yan, additional, Sun, Jing‐Wu, additional, Yang, Qin‐Tai, additional, Li, Xue‐Zhong, additional, Sun, Ya‐Nan, additional, Shi, Li, additional, Wang, Min, additional, Song, Xi‐Cheng, additional, Chen, Fu‐Quan, additional, Zhang, Xiao‐Shu, additional, Wei, Hong‐Quan, additional, Yu, Shao‐Qing, additional, Zhu, Dong‐Dong, additional, Ba, Luo, additional, Cao, Zhi‐Wei, additional, Xiao, Xu‐Ping, additional, Wei, Xin, additional, Lin, Zhi‐Hong, additional, Chen, Feng‐Hong, additional, Shan, Chun‐Guang, additional, Wang, Guang‐Ke, additional, Ye, Jing, additional, Qu, Shen‐Hong, additional, Zhao, Chang‐Qing, additional, Wang, Zhen‐Lin, additional, Li, Hua‐Bin, additional, Liu, Feng, additional, Cui, Xiao‐Bo, additional, Ye, Sheng‐Nan, additional, Liu, Zheng, additional, Xu, Yu, additional, Cai, Xiao, additional, Huang, Wei, additional, Zhang, Ru‐Xin, additional, Zhao, Yu‐Lin, additional, Yu, Guo‐Dong, additional, Shi, Guang‐Gang, additional, Lu, Mei‐Ping, additional, Shen, Yang, additional, Zhao, Yu‐Tong, additional, Pei, Jia‐Hong, additional, Xie, Shao‐Bing, additional, Yu, Long‐Gang, additional, Liu, Ye‐Hai, additional, Gu, Shao‐Wei, additional, Yang, Yu‐Cheng, additional, Cheng, Lei, additional, and liu, Jian‐Feng, additional
- Published
- 2024
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3. Incidence and prognosis of olfactory and gustatory dysfunctions related to SARS‐CoV‐2 Omicron strain infection in China: A national multicenter survey of 35,566 individuals
- Author
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Liu, Meng‐Fan, Ma, Rui‐Xia, Cao, Xian‐Bao, Zhang, Hua, Zhou, Shui‐Hong, Jiang, Wei‐Hong, Jiang, Yan, Sun, Jing‐Wu, Yang, Qin‐Tai, Li, Xue‐Zhong, Sun, Ya‐Nan, Shi, Li, Wang, Min, Song, Xi‐Cheng, Chen, Fu‐Quan, Zhang, Xiao‐Shu, Wei, Hong‐Quan, Yu, Shao‐Qing, Zhu, Dong‐Dong, Ba, Luo, Cao, Zhi‐Wei, Xiao, Xu‐Ping, Wei, Xin, Lin, Zhi‐Hong, Chen, Feng‐Hong, Shan, Chun‐Guang, Wang, Guang‐Ke, Ye, Jing, Qu, Shen‐Hong, Zhao, Chang‐Qing, Wang, Zhen‐Lin, Li, Hua‐Bin, Liu, Feng, Cui, Xiao‐Bo, Ye, Sheng‐Nan, Liu, Zheng, Xu, Yu, Cai, Xiao, Huang, Wei, Zhang, Ru‐Xin, Zhao, Yu‐Lin, Yu, Guo‐Dong, Shi, Guang‐Gang, Lu, Mei‐Ping, Shen, Yang, Zhao, Yu‐Tong, Pei, Jia‐Hong, Xie, Shao‐Bing, Yu, Long‐Gang, Liu, Ye‐Hai, Gu, Shao‐Wei, Yang, Yu‐Cheng, Cheng, Lei, and liu, Jian‐Feng
- Abstract
This cross‐sectional study aimed to determine the epidemiology of olfactory and gustatory dysfunctions related to COVID‐19 in China. This study was conducted by 45 tertiary Grade‐A hospitals in China. Online and offline questionnaire data were obtained from patients infected with COVID‐19 between December 28, 2022, and February 21, 2023. The collected information included basic demographics, medical history, smoking and drinking history, vaccination history, changes in olfactory and gustatory functions before and after infection, and other postinfection symptoms, as well as the duration and improvement status of olfactory and gustatory disorders. Complete questionnaires were obtained from 35,566 subjects. The overall incidence of olfactory and taste dysfunction was 67.75%. Being female or being a cigarette smoker increased the likelihood of developing olfactory and taste dysfunction. Having received four doses of the vaccine or having good oral health or being a alcohol drinker decreased the risk of such dysfunction. Before infection, the average olfactory and taste VAS scores were 8.41 and 8.51, respectively; after infection, they decreased to 3.69 and 4.29 and recovered to 5.83 and 6.55 by the time of the survey. The median duration of dysosmia and dysgeusia was 15 and 12 days, respectively, with 0.5% of patients having symptoms lasting for more than 28 days. The overall self‐reported improvement rate was 59.16%. Recovery was higher in males, never smokers, those who received two or three vaccine doses, and those that had never experienced dental health issues, or chronic accompanying symptoms. The incidence of dysosmia and dysgeusia following infection with the SARS‐CoV‐2 virus is high in China. Incidence and prognosis are influenced by several factors, including sex, SARS‐CoV‐2 vaccination, history of head‐facial trauma, nasal and oral health status, smoking and drinking history, and the persistence of accompanying symptoms.
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- 2024
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4. HIF-1α activates NLRP3 inflammasome to regulate epithelial differentiation in chronic rhinosinusitis
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Zhong, Bing, primary, Sun, Silu, additional, Tan, Kai Sen, additional, Ong, Hsiao Hui, additional, Du, Jintao, additional, Liu, Feng, additional, Liu, Yafeng, additional, Liu, Shixi, additional, Ba, Luo, additional, Li, Jing, additional, Wang, De Yun, additional, and Liu, Jing, additional
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- 2023
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5. The role of hypoxia in the pathophysiology of chronic rhinosinusitis.
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Zhong, Bing, Seah, Jun Jie, Liu, Feng, Ba, Luo, Du, Jintao, and Wang, De Yun
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SINUSITIS ,NASAL mucosa ,HYPOXEMIA ,PATHOLOGICAL physiology ,EPITHELIAL cells - Abstract
Chronic rhinosinusitis (CRS) is a chronic inflammatory disease of the nasal cavity characterized by excessive nasal mucus secretion and nasal congestion. The development of CRS is related to pathological mechanisms induced by hypoxia. Under hypoxic conditions, the stable expression of both Hypoxia inducible factor‐1 (HIF‐1) α and HIF‐2α are involved in the immune response and inflammatory pathways of CRS. The imbalance in the composition of nasal microbiota may affect the hypoxic state of CRS and perpetuate existing inflammation. Hypoxia affects the differentiation of nasal epithelial cells such as ciliated cells and goblet cells, induces fibroblast proliferation, and leads to epithelial‐mesenchymal transition (EMT) and tissue remodeling. Hypoxia also affects the proliferation and differentiation of macrophages, eosinophils, basophils, and mast cells in sinonasal mucosa, and thus influences the inflammatory state of CRS by regulating T cells and B cells. Given the multifactorial nature in which HIF is linked to CRS, this study aims to elucidate the effect of hypoxia on the pathogenic mechanisms of CRS. [ABSTRACT FROM AUTHOR]
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- 2022
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6. Activation of the mTOR/HIF‐1α/VEGF axis promotes M1 macrophage polarization in non‐eosinophilic chronic rhinosinusitis with nasal polyps
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Zhong, Bing, primary, Du, Jintao, additional, Liu, Feng, additional, Liu, Yafeng, additional, Liu, Shixi, additional, Xie, Lifeng, additional, Wang, De yun, additional, and Ba, Luo, additional
- Published
- 2021
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7. Network optimization simulation of wireless temperature sensing device in public area based on ant colony algorithm
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Guo, Hong-Xia, primary, Zhu Ba, Luo Sang, additional, Zhang, Ji-Fu, additional, Bi, Chao, additional, and Zhang, Tao, additional
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- 2021
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8. Elevated microRNA-21 Is a Brake of Inflammation Involved in the Development of Nasal Polyps
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Liu, Ruowu, primary, Du, Jintao, additional, Zhou, Jiao, additional, Zhong, Bing, additional, Ba, Luo, additional, Zhang, Jie, additional, Liu, Yafeng, additional, and Liu, Shixi, additional
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- 2021
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9. Immunopathology Features of Chronic Rhinosinusitis in High-altitude Dwelling Tibetans
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Ba Luo M.D., Liu Feng M.D., Du Jintao Ph.D., Liu Yafeng M.D., Liu Shixi M.D., Ph.D., Zhang Nan Ph.D., and Claus Bachert M.D., Ph.D.
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Otorhinolaryngology ,RF1-547 ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Chronic rhinosinusitis (CRS) presents distinct inflammatory and remodeling patterns in different populations and environments. Tibetan ethnic groups live at high altitudes and in cold weather conditions. We sought to examine whether Tibetans exhibit distinct CRS pathology or characteristics. Sinonasal polyps and mucosal tissue were obtained from 14 Tibetan patients with CRS and nasal polyps (CRSwNPs), 13 patients with CRS without nasal polyps (CRSsNPs), and 12 Tibetan controls. Tissue homogenates and serum samples were assayed for several T-helper (TH) cell cytokines and mediators using enzyme linked immunosorbent assay profiles were measured using quantity polymerase chain reaction. Several key inflammatory cells were examined for immunohistochemical markers. CRSwNPs were characterized by increased mediator promoting eosinophilic inflammation (interleukin [IL]-5, eosinophil cationic protein, and total immunoglobulin E) and slight synergism with expression of IL-8, IL-2sRa, IL-1beta, IL-6, and myeloperoxidase, and a predominance of eosinophils, mast cells, and neutrophils. GATA-3 transcription factor was significantly increased and Foxp3 showed a tendency to be impaired in CRSwNPs compared with controls. CRSsNPs were characterized by significantly high levels of transforming growth factor beta1, increased interferon γ, and a significant enhancement of Foxp3 and T-beta compared with CRSwNPs. There were reduced numbers of inflammatory cells but increased levels of macrophages in CRSsNPs. Compared with CRSsNPs, CRSwNPs present a severe inflammatory reaction and show a TH2 milieu with apparently impaired regulatory T cells (Treg) function and increased inflammatory cells infiltration predominated by eosinophilic and mast cells. In contrast, TH1 polarization with enhanced Treg function and increased levels of macrophages appear in CRSsNPs.
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- 2013
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10. Activation of the mTOR/HIF‐1α/VEGF axis promotes M1 macrophage polarization in non‐eosinophilic chronic rhinosinusitis with nasal polyps.
- Author
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Zhong, Bing, Du, Jintao, Liu, Feng, Liu, Yafeng, Liu, Shixi, Xie, Lifeng, Wang, De yun, and Ba, Luo
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NASAL polyps ,MACROPHAGES ,SINUSITIS ,MACROPHAGE inflammatory proteins ,SERINE/THREONINE kinases ,VASCULAR endothelial growth factors ,CELL physiology - Published
- 2022
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11. Hypoxia‐induced factor‐1α induces NLRP3 expression by M1 macrophages in noneosinophilic chronic rhinosinusitis with nasal polyps
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Zhong, Bing, primary, Du, Jintao, additional, Liu, Feng, additional, Liu, Yafeng, additional, Liu, Shixi, additional, Zhang, Jie, additional, Lin, Ping, additional, Zhou, Jiao, additional, Liu, Jing, additional, Ong, Hsiao Hui, additional, Tan, Kai Sen, additional, Wang, Deyun, additional, and Ba, Luo, additional
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- 2020
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12. The role of preoperative blood eosinophil counts in distinguishing chronic rhinosinusitis with nasal polyps phenotypes
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Zhong, Bing, primary, Yuan, Tian, additional, Du, Jintao, additional, Tan, Kaisen, additional, Yang, Qintai, additional, Liu, Feng, additional, Liu, Yafeng, additional, Ba, Luo, additional, and Liu, Shixi, additional
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- 2020
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13. Effect of Astragalus membranaceus in Ovalbumin-Induced Allergic Rhinitis Mouse Model
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Bing, Zhong, primary, Jin-Tao, Du, additional, Feng, Liu, additional, Ba, Luo, additional, Ya-Feng, Liu, additional, and Shi-Xi, Liu, additional
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- 2019
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14. Hypoxia‐induced factor‐1α induces NLRP3 expression by M1 macrophages in noneosinophilic chronic rhinosinusitis with nasal polyps.
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Zhong, Bing, Du, Jintao, Liu, Feng, Liu, Yafeng, Liu, Shixi, Zhang, Jie, Lin, Ping, Zhou, Jiao, Liu, Jing, Ong, Hsiao Hui, Tan, Kai Sen, Wang, Deyun, and Ba, Luo
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NASAL polyps ,MACROPHAGES ,SINUSITIS - Abstract
Hypoxia-induced factor-1 induces NLRP3 expression by M1 macrophages in noneosinophilic chronic rhinosinusitis with nasal polyps Keywords: chronic rhinosinusitis with nasal polyps; hypoxia-induced factor-1 ; inflammation; macrophage; NOD-like receptor family; pyrin domain containing 3 EN chronic rhinosinusitis with nasal polyps hypoxia-induced factor-1 inflammation macrophage NOD-like receptor family pyrin domain containing 3 582 586 5 02/20/21 20210201 NES 210201 To the Editor, Chronic rhinosinusitis with nasal polyps (CRSwNP) is a widespread chronic inflammatory disease of the nasal mucosa and can manifest in different phenotypes. HIF-1 , hypoxia-induced factor-1 ; NLRP3, NOD-like receptor family, pyrin domain containing 3; eosCRSwNP, eosinophilic chronic rhinosinusitis with nasal polyps gl Additionally, we found that Arg-1-positive type II macrophage was mainly observed in eosCRSwNP, while the INOS-positive type I macrophage was observed mostly in non-eosCRSwNP. [Extracted from the article]
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- 2021
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15. The role of preoperative blood eosinophil counts in distinguishing chronic rhinosinusitis with nasal polyps phenotypes.
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Zhong, Bing, Yuan, Tian, Du, Jintao, Tan, Kaisen, Yang, Qintai, Liu, Feng, Liu, Yafeng, Ba, Luo, and Liu, Shixi
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- 2021
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16. The role of cysteinyl leukotrienes and their receptors in refractory nasal polyps
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Du, Jintao, primary, Ba, Luo, additional, Zhou, Jiao, additional, Yu, Lingyu, additional, Liu, Ruowu, additional, Zhang, Jie, additional, Liu, Feng, additional, Xian, Junming, additional, Liu, Shixi, additional, and Liu, Yafeng, additional
- Published
- 2017
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17. MiR‐194 is involved in morphogenesis of spiral ganglion neurons in inner ear by rearranging actin cytoskeleton via targeting RhoB
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Du, Jintao, primary, Zhang, Xuemei, additional, Cao, Hui, additional, Jiang, Di, additional, Wang, Xianren, additional, Zhou, Wei, additional, Chen, Kaitian, additional, Zhou, Jiao, additional, Jiang, Hongyan, additional, and Ba, Luo, additional
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- 2017
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18. Distinct expression of NK2 homeobox 1 (NKX2‐1) and goblet cell hyperplasia in nasal polyps with different endotypes
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Du, Jintao, primary, Ba, Luo, additional, Li, Bo, additional, Liu, Feng, additional, Hu, Xianting, additional, Zhang, Jie, additional, Liu, Yafeng, additional, Xian, Junming, additional, Liu, Sixi, additional, and Li, Huabin, additional
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- 2017
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19. Association between neutrophil-to-lymphocyte ratio and differentiated thyroid cancer: a meta-analysis
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Liu, Ji-Feng, primary, Ba, Luo, additional, Lv, Hong, additional, Lv, Dan, additional, Du, Jin-Tao, additional, Jing, Xiao-Mei, additional, Yang, Ning-Jing, additional, Wang, Shao-Xin, additional, Li, Chao, additional, and Li, Xiao-Xia, additional
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- 2016
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20. Pharyngeal tonsil manifestation of Langerhans cells sarcoma: A case report and review of the literature
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Bian Pian, Ba Luo, Zhou Peng, Du Jintao, and Liu Shixi
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medicine.medical_specialty ,Chemotherapy ,integumentary system ,business.industry ,medicine.medical_treatment ,Pharyngeal Tonsil ,medicine.disease ,Surgery ,Regimen ,Immunophenotyping ,medicine.anatomical_structure ,Otorhinolaryngology ,Tonsil ,Pediatrics, Perinatology and Child Health ,Medicine ,Immunohistochemistry ,Langerhans cell sarcoma ,Sarcoma ,Radiology ,business - Abstract
Langerhans cell sarcoma (LCS) is an extremely rare malignant disease with multi-organ involvement and a poor prognosis. LCS involvement of tonsil has not been previously reported. However, we present herein a 10-year-old Tibetan boy distressed by LCS arising on the pharyngeal tonsil. Owing to local traditions and customs, he endured a long period of treatment with traditional Tibetan medicine which provided only slight relief at best that delayed an accurate diagnosis and scientific medical treatment. Subsequently, based on CT and MRI scans, combined with pathology features positive immunophenotype for the CD1a and S-100 proteins confirmed the diagnosed of LCS. We performed a surgical resection along with a regimen of E-CHOP chemotherapy was prescribed as new protocols. As a result the patient complete remission symptoms and without relapse has been 20 months.
- Published
- 2011
21. Immunopathology Features of Chronic Rhinosinusitis in High-altitude Dwelling Tibetans
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Du Jintao, Liu Feng, Zhang Nan, Claus Bachert, Liu Yafeng, Ba Luo, and Liu Shixi
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lcsh:Immunologic diseases. Allergy ,T-cell subsets ,neutrophils ,Immunopathology ,high altitude ,Eosinophilic ,medicine ,Immunology and Allergy ,Nasal polyps ,Interleukin 5 ,transcription factor ,Eosinophil cationic protein ,nasal polyps ,biology ,business.industry ,Interleukin ,FOXP3 ,Articles ,medicine.disease ,lcsh:Otorhinolaryngology ,lcsh:RF1-547 ,Chronic rhinosinusitis ,Otorhinolaryngology ,Myeloperoxidase ,Immunology ,biology.protein ,Tibetan patients ,eosinophils ,interleukin-5 ,business ,lcsh:RC581-607 - Abstract
Chronic rhinosinusitis (CRS) presents distinct inflammatory and remodeling patterns in different populations and environments. Tibetan ethnic groups live at high altitudes and in cold weather conditions. We sought to examine whether Tibetans exhibit distinct CRS pathology or characteristics. Sinonasal polyps and mucosal tissue were obtained from 14 Tibetan patients with CRS and nasal polyps (CRSwNPs), 13 patients with CRS without nasal polyps (CRSsNPs), and 12 Tibetan controls. Tissue homogenates and serum samples were assayed for several T-helper (TH) cell cytokines and mediators using enzyme linked immunosorbent assay profiles were measured using quantity polymerase chain reaction. Several key inflammatory cells were examined for immunohistochemical markers. CRSwNPs were characterized by increased mediator promoting eosinophilic inflammation (interleukin [IL]-5, eosinophil cationic protein, and total immunoglobulin E) and slight synergism with expression of IL-8, IL-2sRa, IL-1beta, IL-6, and myeloperoxidase, and a predominance of eosinophils, mast cells, and neutrophils. GATA-3 transcription factor was significantly increased and Foxp3 showed a tendency to be impaired in CRSwNPs compared with controls. CRSsNPs were characterized by significantly high levels of transforming growth factor beta1, increased interferon γ, and a significant enhancement of Foxp3 and T-beta compared with CRSwNPs. There were reduced numbers of inflammatory cells but increased levels of macrophages in CRSsNPs. Compared with CRSsNPs, CRSwNPs present a severe inflammatory reaction and show a TH2 milieu with apparently impaired regulatory T cells (Treg) function and increased inflammatory cells infiltration predominated by eosinophilic and mast cells. In contrast, TH1 polarization with enhanced Treg function and increased levels of macrophages appear in CRSsNPs.
- Published
- 2013
22. Effect of Astragalus membranaceusin Ovalbumin-Induced Allergic Rhinitis Mouse Model
- Author
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Bing, Zhong, Jin-Tao, Du, Feng, Liu, Ba, Luo, Ya-Feng, Liu, and Shi-Xi, Liu
- Abstract
Background Astragalus membranaceus(AM), a traditional Chinese medicine, has been used to treat allergic diseases, but the mechanism for treating allergic rhinitis (AR) remains unclear.Objective The purpose of this study was to look at the anti-inflammatory effect of AM on AR and the mechanism of anti-allergy.Methods The mouse model of AR was induced by ovalbumin. Allergic symptoms, number of eosinophils in nasal mucosa, and levels of inflammatory cells in nasal lavage fluid were analyzed. We explored the serum immunoglobulin E (IgE), interleukin-4 (IL-4), IL-5, IL-13, interferon-γ (IFN-γ), and IL-10. Besides, the relative mRNA of IL-4, IL-5, and IL-13 was also detected in nasal mucosa tissue. The proportion of CD4+CD25+Foxp3+T cells in the spleen and nasal lymphoid tissue were analyzed. The mRNA levels of nuclear factor-kappa B p65 (NF-κB p65) and inhibitory kappa B alpha (IκBα), as well as NF-κB p65 DNA binding activity, were tested. We also measured the protein levels of NF-κB p65 and p-NF-κB p65 in nasal mucosa.Results AM could reduce the number of eosinophils in the nasal mucosa and decrease the levels of inflammatory cells in nasal lavage fluid. The serum IgE, IL-4, IL-5, and IL-13 were also decreased, while levels of IFN-γ and IL-10 were increased. The relative mRNA of IL-4, IL-5, and IL-13 was decreased by AM. AM increased the proportion of CD4+CD25+Foxp3+T cells in the spleen and nasal lymphoid tissue. In addition, AM could reduce the activity of NF-kB by inhibiting the mRNA expression and DNA binding activity of NF-κB p65. However, AM had no significant effect on mRNA of IκBα. Above all, AM could reduce the p-NF-κB p65 protein expression of nasal mucosa.Conclusions AM could reduce the secretion of inflammatory cytokines by increasing the level of CD4+CD25+Foxp3+T cells and inhibiting the activation of the NF-κB.
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- 2019
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23. Distinct Inflammatory Profiles in Atopic and Nonatopic Patients With Chronic Rhinosinustis Accompanied by Nasal Polyps in Western China
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Ba, Luo, primary, Du, Jintao, additional, Liu, Feng, additional, Yang, Fenglin, additional, Han, Miaomiao, additional, Liu, Sixi, additional, Lin, Ping, additional, and Li, Huabin, additional
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- 2015
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24. Expression of TGF, matrix metalloproteinases, and tissue inhibitors in Chinese chronic rhinosinusitis
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Shixi Liu, Yafeng Liu, Juan Meng, Ba Luo, Yongbo Zheng, Peng Zhou, Jie Zhang, Nan Zhang, Claus Bachert, Feng Liu, Xiaoyuan Li, Gabriele Holtappels, Xiaoming Qiao, and Ping Lin
- Subjects
Adult ,Male ,Adolescent ,Immunology ,Matrix metalloproteinase ,Extracellular matrix ,Young Adult ,Nasal Polyps ,Asian People ,Immunology and Allergy ,Medicine ,Humans ,Nasal polyps ,Sinusitis ,TGF beta 1 ,Rhinitis ,Eosinophil cationic protein ,biology ,business.industry ,FOXP3 ,Tissue Inhibitor of Metalloproteinases ,Tissue inhibitor of metalloproteinase ,Middle Aged ,medicine.disease ,Matrix Metalloproteinases ,Transforming Growth Factors ,Chronic Disease ,biology.protein ,Immunohistochemistry ,Female ,business - Abstract
Background To date there is no information on the expression of mediators associated with tissue remodeling in Asian patients with chronic rhinitis with (CRSwNP) or without (CRSsNP) nasal polyps. Objectives To study the expression of TGF-β1, matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinases (TIMPs), collagen, and regulatory T cells in Chinese patients with CRSwNP and CRSsNP. Methods Thirty-six male and female subjects (12 patients with CRSwNP, 12 patients with CRSsNP, and 12 control subjects), age 17 to 60 years, were recruited into the study. Samples were collected from polyp and sinusoidal mucosal, ethmoidal mucosal, or inferior turbinate in the respective groups and assessed for TGF- β1, MMP-2, MMP-7, MMP-9, TIMP-1, TIMP-2, TIMP-3, and TIMP-4 by immunoassay; collagen by histochemistry; and forkhead box P3 (FOXP3) mRNA by real-time PCR. Results Patients with CRSwNP showed significantly lower concentrations of TGF-β1, TIMP-1, TIMP-4, FOXP3, and collagen compared with patients with CRSsNP. Although there were no significant differences between the concentrations of MMP-7 and MMP-9 in patients with CRSwNP and CRSsNP, these were significantly increased compared with control patients. MMP-2 and TIMP-2 concentrations were not significantly different in any patient group, whereas TIMP-3 was not detectable. Conclusion Chronic rhinosinusitis with nasal polyps is characterized by a relative lack of TGF-s expression versus CRSsNP. This finding may be causal for decreased collagen, TIMP-1/4, and FOXP3 expression in CRSwNP versus CRSsNP. TGF-s serves as a main switch for different remodeling patterns in sinus disease.
- Published
- 2009
25. Reply
- Author
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Michael Fallon, Ba Luo, and Gary A Abrand
- Subjects
Hepatology - Published
- 1999
26. [Expert consensus on the diagnosis and treatment of respiratory diseases exacerbated by nonsteroidal anti-inflammatory drugs (2024, Chengdu)].
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Meng J, Ye J, Zhang L, Xu Y, Liu W, Yang Y, Wang X, Jiang Y, Qiu Q, Li J, Yu S, Liu F, Lou H, Wang H, Yu G, Xu R, Meng C, Sun N, Chen J, Zeng M, Xie Z, Sun Y, Tang J, Zhao K, Zhang W, Shi Z, Xu C, Yang Y, Lu M, Ye H, Wei X, Sun B, An Y, Sun Y, Gu Y, Zhang T, Ba L, Yang Q, Xu Y, Yang G, Hong H, Zuo K, and Li H
- Subjects
- Humans, China, Rhinitis diagnosis, Rhinitis therapy, Rhinitis chemically induced, Sinusitis diagnosis, Sinusitis therapy, Sinusitis drug therapy, Consensus, Asthma diagnosis, Asthma drug therapy, Chronic Disease, Anti-Inflammatory Agents, Non-Steroidal adverse effects
- Abstract
Non-steroidal anti-inflammatory drugs-exacerbated respiratory disease (N-ERD) is a chronic respiratory disease characterized by eosinophilic inflammation, featuring chronic rhinosinusitis (CRS), asthma, and intolerance to cyclooxygenase 1 (COX-1) inhibitors. The use of these medications can lead to an acute worsening of rhinitis and asthma symptoms. This condition has not yet received sufficient attention in China, with a high rate of misdiagnosis and a lack of related research. The Chinese Rhinology Research Group convened a group of leading young experts in otolaryngology from across the country, based on the latest domestic and international evidence-based medical practices to formulate this consensus.The consensus covers the epidemiology, pathogenesis, clinical manifestations, diagnostic methods, and treatment strategies for N-ERD, including pharmacotherapy, surgery, biologic treatments, and desensitization therapy. The goal is to improve recognition of N-ERD, reduce misdiagnosis, and enhance treatment outcomes., Competing Interests: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose., (Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.)
- Published
- 2024
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27. The oxidant-antioxidant imbalance was involved in the pathogenesis of chronic rhinosinusitis with nasal polyps.
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Zhou J, Zhou J, Liu R, Liu Y, Meng J, Wen Q, Luo Y, Liu S, Li H, Ba L, and Du J
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- Humans, Chronic Disease, Female, Male, Adult, Middle Aged, Oxidants metabolism, Macrophages metabolism, Macrophages immunology, Cytokines metabolism, Nasal Mucosa metabolism, Nasal Mucosa immunology, Cells, Cultured, Rhinosinusitis, Nasal Polyps metabolism, Nasal Polyps immunology, Sinusitis metabolism, Sinusitis immunology, Rhinitis metabolism, Rhinitis immunology, Antioxidants metabolism, Oxidative Stress
- Abstract
Background: Although oxidative stress is involved in the pathophysiological process of chronic rhinosinusitis with nasal polyps (CRSwNP), the specific underlying mechanism is still unclear. Whether antioxidant therapy can treat CRSwNP needs further investigation., Methods: Immunohistochemistry, immunofluorescence, western blotting and quantitative polymerase chain reaction (qPCR) analyses were performed to detect the distribution and expression of oxidants and antioxidants in nasal polyp tissues. qPCR revealed correlations between oxidase, antioxidant enzymes and inflammatory cytokine levels in CRSwNP patients. Human nasal epithelial cells (HNEpCs) and primary macrophages were cultured to track the cellular origin of oxidative stress in nasal polyps(NPs) and to determine whether crocin can reduce cellular inflammation by increasing the cellular antioxidant capacity., Results: The expression of NOS2, NOX1, HO-1 and SOD2 was increased in nasal epithelial cells and macrophages derived from nasal polyp tissue. Oxidase levels were positively correlated with those of inflammatory cytokines (IL-5 and IL-6). Conversely, the levels of antioxidant enzymes were negatively correlated with those of IL-13 and IFN-γ. Crocin inhibited M1 and M2 macrophage polarization as well as the expression of NOS2 and NOX1 and improved the antioxidant capacity of M2 macrophages. Moreover, crocin enhanced the ability of antioxidants to reduce inflammation via the KEAP1/NRF2/HO-1 pathway in HNEpCs treated with SEB or LPS. Additionally, we observed the antioxidant and anti-inflammatory effects of crocin in nasal explants., Conclusion: Oxidative stress plays an important role in the development of CRSwNP by promoting various types of inflammation. The oxidative stress of nasal polyps comes from epithelial cells and macrophages. Antioxidant therapy may be a promising strategy for treating CRSwNP., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Zhou, Zhou, Liu, Liu, Meng, Wen, Luo, Liu, Li, Ba and Du.)
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- 2024
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28. Psychological Resilience of Chinese College Students: A Cross-Sectional Study after the Deblocking of China's COVID-19 Pandemic Strategy.
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Zhao R, Peng J, Li JY, Qin LL, and Luo BA
- Abstract
Psychological resilience (PR) plays an important role in fortifying mental health during pandemics. This study aimed to examine the PR and its related factors of college students in China after the deblocking of the China's COVID-19 pandemic strategy. A total of 1100 college students from 15 universities participated in this cross-sectional survey by multi-stage stratified sampling. Data were collected by self-designed socio-demographic information, the family function assessment scale (APGAR), a general health questionnaire (GHQ-12), the general self-efficacy scale (GSES), and a psychological resilience scale. The average score of PR was 135.65 ± 18.54. Cluster analysis of PR scores showed that 24.9% of the college students had weak PR. The higher PR, the higher mental health status (r = 0.352, p < 0.05). Females had higher PR than males (OR = 0.550, 95% CI: 0.367-0.827). High self-efficacy was an independent protective factor of high PR (OR = 0.093, 95% CI: 0.059-0.145). Low family contact frequency, poor family function, and bad mental health status were the independent risk factors of high PR. In conclusion, the PR of Chinese college students were insufficient after the deblocking of China's COVID-19 pandemic strategy, indicating an improvement of PR should be put into practice immediately. Frequent monthly contact with family, family function, self-efficacy, mental health status, and gender were the influencing factors of PR, which provides an intervention strategy for the future.
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- 2023
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29. The Fully Mediating Role of Psychological Resilience between Self-Efficacy and Mental Health: Evidence from the Study of College Students during the COVID-19 Pandemic.
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Qin LL, Peng J, Shu ML, Liao XY, Gong HJ, Luo BA, and Chen YW
- Abstract
Student populations are susceptible to the COVID-19 pandemic and may easy develop mental health problems related to their immaturity of psychological development and fluctuation of mood. However, little has been known about the effects of the pandemic on college students and the associated influencing factors. This study aimed to explore the role of psychological resilience as a mediator between general self-efficacy and mental health. A cross-sectional survey was conducted with 480 Chinese college students from 12 universities in Hunan province of China. The participants responded anonymously to the Generalized Self-Efficacy Scale (GSES), the Chinese version of the Resilience Scale for College Students (RSCS), and the 12-item General Health Questionnaire (GHQ-12). Hierarchical linear regression and structural equation modeling were used in this study. The average of GSES and RSCS scores of college students were 25.00 ± 4.68 and 137.97 ± 15.50, which were at a medium level. The average score for the GHQ-12 was 1.59 ± 1.59, and 22.03% of the college students scored ≥ 3 on the GHQ-12, indicating that they were at risk of developing mental disorders. According to the analyses of mediation effect, psychological resilience played a fully mediating role in the relationship between general self-efficacy and mental health. In conclusion, Chinese college students were at high risk of developing mental disorders during the COVID-19 period. General self-efficacy was positively associated with psychological resilience, and psychological resilience played a fully mediating role in the relationship between general self-efficacy and mental health. Future studies and interventions should aim to promote psychological resilience and general self-efficacy.
- Published
- 2023
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30. Mental health resources and its equity in Central South of China: A case study of Hunan Province.
- Author
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Luo BA, Li S, Chen S, Qin LL, Chen YW, Shu ML, and Liao XY
- Subjects
- China, Health Services Accessibility, Humans, Mental Health, Resource Allocation, Health Equity, Health Resources
- Abstract
Objectives: Mental health resources are an important basis for coping with mental health services. The equity is an important index of a reasonable allocation of health resources. This study aims to evaluate the mental health resources and its equity allocation in Hunan Province, which is one of the typical central south areas of China, so as to provide reference for the development of mental health in China and other areas., Methods: Data related to mental health resources was obtained from the Project of Mental Health Resources in Hunan Province, which was conducted by the Department of Hunan Mental Health Center in 2019. The Gini coefficient, the Theil index and other indicators were employed to quantitatively evaluate the equity of mental health resources' allocation., Results: By the end of 2018, there were a total of 141 mental health institutions in Hunan Province of China, the bed density was 5.31 beds per 10,000 people, the ratio of doctors to nurses was 2.20, the number of outpatients of mental health institutions was 1288,047 per year. The mental health resources' allocation in terms of demographic dimension were in a preferred status with the Gini values all less than 0.3, and the Gini values for mental health resources`allocation in terms of geographical dimension ranged from 0.24 to 0.35. The Theil index for mental health allocation in terms of demographic dimension was lower than 0.05, and the Theil index for mental health allocation in terms of geographical dimension ranged from 0.04 to 0.11., Conclusions: The shortage of mental health resources is still the priority issue to be increased and optimized by policy-makers in Hunan in the future, especially the human resources. Moreover, the utilization of mental health resources was low though its equity was fair. Policy-makers need to consider the high utilization and geographical accessibility of health resources among different regions to ensure people in different regions could get access to available health services., Competing Interests: The authors have declared that no competing interests exist.
- Published
- 2022
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31. [Summary of experience in cochlear implantation surgery in Tibet and analysis of postoperative rehabilitation effect].
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Xu X, Gongga L, Cai S, Ba L, Zheng H, Yu L, and Suolang Z
- Subjects
- Humans, Infant, Newborn, Oxygen, Retrospective Studies, Tibet, Treatment Outcome, Cochlear Implantation, Cochlear Implants, Hearing Loss, Sensorineural diagnosis, Speech Perception
- Abstract
Cochlear implant surgery is now recognized as the most effective intervention for patients with severe and profound sensorineural hearing loss. Due to various factors such as high altitude, low oxygen content, and ethnic differences in Tibet, the early hearing screening found that the incidence of neonatal hearing loss was significantly higher than in the mainland. With the great assistance of the China Disabled Persons' Federation, the first cochlear implant surgery was carried out in Tibet in 2011, and a total of 116 cases have been completed. This article aims to summarize the clinical experience of cochlear implant surgery in Tibet for ten years and retrospectively analyze the postoperative rehabilitation effect, so as to improve the understanding of cochlear implant surgery in plateau areas., Competing Interests: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose., (Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.)
- Published
- 2022
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- View/download PDF
32. Researching on the compliance of epilepsy patients of the Phenobarbital Epilepsy Management Project in a rural area of China: A retrospective study.
- Author
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Feng XL, Luo BA, and Qin LL
- Subjects
- Adolescent, Adult, Anticonvulsants administration & dosage, Child, Child, Preschool, China, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Phenobarbital administration & dosage, Retrospective Studies, Rural Population, Young Adult, Anticonvulsants therapeutic use, Epilepsy drug therapy, Patient Compliance statistics & numerical data, Phenobarbital therapeutic use
- Abstract
Abstract: The aim of this study was to explore the compliance of epilepsy patients in the Phenobarbital Epilepsy Management Project in a rural area of China and its influencing factors, so as to provide the basis for further strategies.A retrospective study researching on the compliance of epilepsy patients in the Phenobarbital Epilepsy Management Project of Rural China was conducted. The Nan County, Hunan Province as a typical rural China was selected as the study site. We collected the compliance and other relative factors from 2017 to 2019 though the Phenobarbital Epilepsy Management Project data system.The good compliance patients in the Phenobarbital Epilepsy Management Project in a rural area of China were 98.99% (393/397); only 4 cases had poor compliance. The factors affecting the compliance of epilepsy patients were "adverse reactions of digestive tract symptoms," "how the patient felt physically, mentally, or working and learning ability during this period," and "the ratio of the attack to the previous one."The rate of good compliance among the epilepsy patients in the Phenobarbital Epilepsy Management Project in a rural area of China was high. More attention to education, patients' psychology, and the curative effect of family members may improve the compliance of patients with epilepsy further., Competing Interests: The authors report no conflicts of interest., (Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.)
- Published
- 2021
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33. Association between cigarette smoking and the risk of dysmenorrhea: A meta-analysis of observational studies.
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Qin LL, Hu Z, Kaminga AC, Luo BA, Xu HL, Feng XL, and Liu JH
- Subjects
- Adolescent, Adult, Asia epidemiology, Child, Europe epidemiology, Female, Humans, Middle Aged, North America epidemiology, Observational Studies as Topic, Oceania epidemiology, Odds Ratio, Risk Factors, Smokers statistics & numerical data, Smoking Cessation, Young Adult, Cigarette Smoking adverse effects, Dysmenorrhea epidemiology, Smoking adverse effects, Tobacco Smoking adverse effects
- Abstract
Background: Emerging studies have found inconsistent results on the potential relationship between cigarette smoking and dysmenorrhea. Therefore, the aim of this study was to quantitatively synthesize the previous findings on the preceding relationship using meta-analysis., Methods: Previous studies on the association between cigarette smoking and dysmenorrhea, published not later than November 2019, were systematically searched, using MeSH heading and/or relevant terms, in the electronic databases of PubMed, Medline, Web of Science and EMBASE. The I2 statistic was used to assess heterogeneity, whose source was explored using subgroup analysis. A pooled effect size was obtained using random effects model, and sensitivity analysis was performed to assess the consistency of the pooled effect size., Results: After a rigorous screening process, 24 studies involving 27,091 participants were included in this meta-analysis. The results indicated that smokers were 1.45 times more likely to develop dysmenorrhea than non-smokers (odds ratio (OR) = 1.45, 95% confidence interval (CI): 1.30-1.61). In addition, individuals classified as currently smoking were 1.50 times more likely to develop dysmenorrhea than those who were classified as never smoking (OR = 1.50, 95% CI: 1.33-1.70), whereas being a former smoker was 1.31 times more likely to develop dysmenorrhea than being a never smoker (OR = 1.31, 95% CI: 1.18-1.46). Sensitivity analysis showed that exclusion of any single study did not materially alter the overall combined effect., Conclusion: The evidence from this meta-analysis indicated a significant association between cigarette smoking (both current and former smoking) and dysmenorrhea. The adverse effects of smoking provide further support for prevention of dysmenorrhea and emphasize the need to target women., Competing Interests: The authors have declared that no competing interests exist.
- Published
- 2020
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34. Effect of Exposure to Famine during Early Life on Risk of Metabolic Syndrome in Adulthood: A Meta-Analysis.
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Qin LL, Luo BA, Gao F, Feng XL, and Liu JH
- Subjects
- Adolescent, Adult, Humans, Prevalence, Risk, Famine, Malnutrition complications, Metabolic Syndrome epidemiology, Metabolic Syndrome etiology
- Abstract
Background: Emerging studies have explored the association between the famine exposure during early life and the risk of the metabolic syndrome, and the results remain controversial. This meta-analysis was performed to summarize the famine effects on the prevalence of metabolic syndrome (MetS) in adulthood. Materials and Methods. We searched the PubMed, Web of Science, Embase, ScienceDirect, and Chinese National Knowledge Infrastructure for relevant studies up to December 2019. Pooled odd ratios (ORs) with 95% confidence intervals (CIs) were used to estimate the effect exposure to famine on MetS using a random-effects model, and the I
2 was used to evaluate the heterogeneity., Results: The analyses included 39 studies from 10 articles with a total of 81504 participants. Fourteen studies from 10 articles for fetal famine exposure, 20 studies from 7 articles for childhood famine exposure, and 5 studies from 3 articles for adolescence/adult famine exposure were included in this meta-analysis. Compared with a nonexposed group, famine exposure significantly increased the risk of MetS for early life famine exposure (OR = 1.27, 95% CI: 1.18-1.38), fetal famine exposure (OR = 1.27, 95% CI: 1.14-1.43), and childhood famine exposure (OR = 1.29, 95% CI: 1.16-1.44). Subgroup analyses showed that the result was consistent regardless of the study designs, definitions of MetS, and causes of famine, with or without adjustment for age, smoking, drinking, and physical activity., Conclusions: This meta-analysis suggests that exposure to famine during early life may increase the risk of MetS in adulthood., Competing Interests: The authors declare that they have no conflicts of interest., (Copyright © 2020 Lu-Lu Qin et al.)- Published
- 2020
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- View/download PDF
35. The association between vitamin D deficiency and community-acquired pneumonia: A meta-analysis of observational studies.
- Author
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Zhou YF, Luo BA, and Qin LL
- Subjects
- Community-Acquired Infections etiology, Humans, Risk Factors, Pneumonia, Bacterial etiology, Pneumonia, Viral etiology, Vitamin D Deficiency complications
- Abstract
Emerging evidence has shown that vitamin D deficiency may be related with community-acquired pneumonia (CAP), but individually published studies showed inconclusive results. The aim of this study was to quantitatively summarize the association between vitamin D and the CAP.We conducted this meta-analysis though a systematic literature search of PubMed, Medline, and EMBASE up to 31 September 2018 with the following keywords 'vitamin D' or 'cholecalciferol' or '25-hydroxyvitamin D' or '25(OH)D' in combination with 'community-acquired pneumonia' or 'CAP' or 'pneumonia' with no limitations. This meta-analysis was performed following the guidelines of Meta-analysis of Observational Studies in Epidemiology. The association between vitamin D levels and CAP were measured as odds ratio (OR) and weighted mean difference (WMD). Results were combined using a random-effect or a fix-effect meta-analysis, and sensitivity analyses were conducted to explore potential factors.Eight observational studies involving 20,966 subjects were included. In this meta-analysis, CAP patients with vitamin D deficiency (serum 25(OH)D levels <20 ng/mL) experienced a significantly increased risk of CAP (odds ratio (OR) = 1.64, 95% confidence intervals (CI): 1.00, 2.67), and an obvious decrease of -5.63 ng/mL (95% CI: -9.11, -2.14) in serum vitamin D was demonstrated in CAP patients. Sensitivity analysis showed that exclusion of any single study did not materially alter the overall combined effect.The evidence from this meta-analysis indicates an association between vitamin D deficiency and an increased risk of CAP patients. However, well-designed trails are required to determine the explicit effect of vitamin D supplementation.
- Published
- 2019
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36. Association between physical activity and health-related quality of life in elderly individuals with pre-diabetes in rural Hunan Province, China: a cross-sectional study.
- Author
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Xu H, Tang L, Hu Z, Gao F, Yang Y, Qin L, and Luo BA
- Subjects
- Aged, China, Cross-Sectional Studies, Female, Health Status, Humans, Male, Middle Aged, Rural Population, Surveys and Questionnaires, Exercise, Prediabetic State physiopathology, Quality of Life
- Abstract
Objectives: There are few data on the relationship between health-related quality of life (HRQoL) and physical activity among elderly individuals with pre-diabetes. This study aimed to determine if differences existed in HRQoL between individuals with pre-diabetes who were physically active compared with those who were physically inactive in rural China., Design, Setting and Participants: A cross-sectional survey was conducted among the elderly (≧60 years) in rural communities in Yiyang City of China. Multistage cluster random sampling was carried out to select 42 areas, and interviews were conducted among 434 elderly individuals with pre-diabetes. Pre-diabetes was screened using an oral glucose tolerance test., Main Outcome Measures: The Medical Outcomes Study 36-Item Short Form Health Survey questionnaire was used to measure HRQoL. Physical activity was assessed using the International Physical Activity Questionnaire. Multivariate analysis of covariance (MANCOVA) was used to test for differences in HRQoL between the physically active group and the inactive group., Results: A total of 434 individuals with pre-diabetes were included in this study. The physical component summary (PCS) score of HRQoL was 42.1±10.2 and the mental component summary score was 46.4±8.9. A median total physical activity of 524 metabolic equivalent-min/week was reported. A significant MANCOVA model (Wilks' λ=0.962, F (2,423)=8.44, P<0.001) indicated that elderly individuals with pre-diabetes who were physically active reported higher PCS scores (M
diff =5.2, P<0.001, effective size=0.47) compared with those physically inactive after adjusting for the following covariates: age, gender, marital status, education, smoking, chronic disease, body mass index and waist:hip ratio., Conclusions: The HRQoL of elderly individuals with pre-diabetes is poor in rural China. These findings demonstrated that elderly individuals with pre-diabetes who were physically active had higher PCS scores than those who were physically inactive. Furthermore, these results support the rationale for developing a physical activity intervention for HRQoL of individuals with pre-diabetes., Trial Registration Number: ChiCTR-IOR-15007033; Results., Competing Interests: Competing interests: None declared., (© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.)- Published
- 2018
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37. Effect of revision dacryocystorhinostomy under nasal endoscopy on recrudescent dacryocystitis.
- Author
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Du J, Zhong B, Xian J, Ba L, Liu F, and Liu Y
- Abstract
Objective: Patients with recurrent dacryocystitis are difficult to treat. We aimed to observe the role of dacryocystography in locating the site of obstruction and the effect of revision surgery in these cases of recurrent dacryocystitis., Method: We prospectively collected patients with recurrent dacryocystitis at West China Hospital of Sichuan University. Dacryocystography was performed before surgery. After revision endoscopy dacryocystorhinostomy (DCR), patients were followed-up regularly. Clinical features were recorded before and after operation, including the visual analog scale (VAS) score. Using the software of SPSS 13.0, VAS scores were compared between preoperation and postoperation by a Student's t test and repeated measure ANOVA., Results: Twenty patients were collected; eight cases had a history of a one-time occurrence of DCR, and 12 cases had a history of two or more occurrence of DCR. Dacryocystography could show the site with the most lacrimal obstruction. During the operation, we could resect most of the lacrimal sac medial bone wall and expose the sac successfully. Follow-up showed no relapse occurrences and only one case had a slightly tearful eye subjectively but had enough big orificium fistulae and favorable mucosal epithelialization that it was similar to other cases. The VAS scores at follow-up decreased significantly compared with preoperation (P<0.05)., Conclusion: For patients with recurrent dacryocystitis, dacryocystography could clarify the cause and exact site of the obstruction and provide information for further treatment. Through revision endoscope DCR, patients can effectively achieve enough drainage of the lacrimal sac accompanied with a significant improvement in symptoms and no observable complications., Competing Interests: None., (IJCEP Copyright © 2017.)
- Published
- 2017
38. The Association between Vitamin D Deficiency and Diabetic Retinopathy in Type 2 Diabetes: A Meta-Analysis of Observational Studies.
- Author
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Luo BA, Gao F, and Qin LL
- Subjects
- Databases, Factual, Diabetes Mellitus, Type 2 blood, Diabetic Retinopathy blood, Humans, Observational Studies as Topic, Risk Factors, Sensitivity and Specificity, Vitamin D administration & dosage, Vitamin D Deficiency blood, Diabetes Mellitus, Type 2 epidemiology, Diabetic Retinopathy epidemiology, Vitamin D blood, Vitamin D Deficiency epidemiology
- Abstract
Emerging evidence from in vivo and in vitro studies have shown that vitamin D may play an important role in the development of diabetic retinopathy (DR), but individually published studies showed inconclusive results. The aim of this study was to quantitatively summarize the association between vitamin D and the risk of diabetic retinopathy. We conducted a systematic literature search of Pubmed, Medline, and EMBASE updated in September 2016 with the following keywords: "vitamin D" or "cholecalciferol" or "25-hydroxyvitamin D" or "25(OH)D" in combination with "diabetic retinopathy" or "DR". Fifteen observational studies involving 17,664 subjects were included. In this meta-analysis, type 2 diabetes patients with vitamin D deficiency (serum 25(OH)D levels <20 ng/mL) experienced a significantly increased risk of DR (odds ratio (OR) = 2.03, 95% confidence intervals (CI): 1.07, 3.86), and an obvious decrease of 1.7 ng/mL (95% CI: -2.72, -0.66) in serum vitamin D was demonstrated in the patients with diabetic retinopathy. Sensitivity analysis showed that exclusion of any single study did not materially alter the overall combined effect. In conclusion, the evidence from this meta-analysis indicates an association between vitamin D deficiency and an increased risk of diabetic retinopathy in type 2 diabetes patients.
- Published
- 2017
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39. Does Maternal Vitamin D Deficiency Increase the Risk of Preterm Birth: A Meta-Analysis of Observational Studies.
- Author
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Qin LL, Lu FG, Yang SH, Xu HL, and Luo BA
- Subjects
- Biomarkers blood, Chi-Square Distribution, Female, Gestational Age, Health Status, Humans, Observational Studies as Topic, Odds Ratio, Pregnancy, Risk Assessment, Risk Factors, Vitamin D analogs & derivatives, Vitamin D blood, Vitamin D Deficiency blood, Vitamin D Deficiency diagnosis, Infant, Premature, Maternal Health, Premature Birth epidemiology, Vitamin D Deficiency epidemiology
- Abstract
There are disagreements among researchers about the association between vitamin D deficiency during pregnancy and preterm birth (PTB). Therefore, we conducted a meta-analysis of observational studies to evaluate this association. We performed a systematic literature search of PubMed, MEDLINE and the Cochrane Library through August 2015 with the following keywords: "vitamin D" or "cholecalciferol" or "25-hydroxyvitamin D" or "25(OH)D" in combination with "premature birth" or "preterm birth" or "PTB" or "preterm delivery" or "PTD" or "prematurity". Our meta-analysis of 10 studies included 10,098 participants and found that pregnant women with vitamin D deficiency (maternal serum 25 (OH) D levels < 20 ng/mL) experienced a significantly increased risk of PTB (odds ratio (OR) = 1.29, 95% confidence intervals(CI): 1.16, 1.45) with low heterogeneity (I² = 25%, p = 0.21). Sensitivity analysis showed that exclusion of any single study did not materially alter the overall combined effect. In the subgroup analyses, we found that heterogeneity was obvious in prospective cohort studies (I² = 60%, p = 0.06). In conclusion, pregnant women with vitamin D deficiency during pregnancy have an increasing risk of PTB.
- Published
- 2016
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40. [The expression of interleukin-17 in blood and nasal tissue of patients with allergic rhinltis and nasal polyps].
- Author
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Du JT, Ba L, Shang TT, Liu YF, Wei DP, and An HM
- Subjects
- Adolescent, Adult, Eosinophils immunology, Female, Humans, Interleukin-17 blood, Leukocyte Count, Male, Middle Aged, Young Adult, Interleukin-17 metabolism, Nasal Polyps metabolism, Rhinitis, Allergic, Perennial metabolism
- Abstract
Objective: To study the expression of IL-17 in blood and nasal tissue of allergic rhinitis and nasal polyps, and to investigate the possible mechanism of IL-17 in the progress of allergic rhinitis and nasal polyps., Methods: There were 41 patients enrolled, including the patients with allergic rhinitis, nasal polyps and deviated nasal septum. The blood and nasal mucosa tissue or nasal polyps were collected in all the patients. The expression of IL-17 was measured by the methods of ELISA and immunohistochemisty, and the number of eosinophils and IL-17 positive cells was measured., Results: The IL-17 expression of nasal polyps was significantly elevated in the blood and nasal tissue, which was obviously correlated with the number of eosinophils infiltrated in nasal tissue. However, for the patients with allergic rhinitis, there was only apparent expression of IL-17 in nasal mucosa., Conclusion: IL-17 plays an important role in the development of nasal polyps, but for allergic rhinitis, it needs further study as an potential important aspect of the pathogenesis.
- Published
- 2010
41. [The expression and significance of interleukin-17 and the infiltrating eosinophils in nasal polyps and nasal mucous of allergic rhinitis].
- Author
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Ba L, Du J, Liu Y, Shang T, Yang F, and Bian P
- Subjects
- Adolescent, Adult, Aged, Case-Control Studies, Female, Humans, Inflammation, Male, Middle Aged, Nasal Mucosa metabolism, Nasal Polyps pathology, Rhinitis pathology, Young Adult, Eosinophils metabolism, Interleukin-17 metabolism, Nasal Polyps metabolism, Rhinitis metabolism
- Abstract
Objective: To observe the expression of interleukin-17 and the infiltration of eosinophilic cells in nasal polyps and allergic rhinitis, and investigate the roles of IL-17 and eosinophils in the etiology of nasal polyps and allergic rhinitis., Method: A study was conducted on 21 patients of nasal polyps, 18 ones of allergic rhinitis and 12 normal individuals. Immunohistochemical stain with the rabbit monoclonal antibodies of IL-17 was carried out. The eosinophilic cells infiltrated in different tissues were stained with HE, then counted under high power filed. The data was analyzed with ANOVA of SPSS12.0 software., Result: Many IL-17 stained cells were found in the samples of nasal polyps and allergic rhinitis, which were significantly higher than those in normal individuals (P < 0.05). Positive cell number in tissues of allergic rhinitis was similar to that in nasal polyps, but higher than in normal individuals. As for HE staining, there was no significant deviation of numbers of eosinophilic cell in tissue between allergic rhinitis and nasal polyps,while which differed from the normal ones (P < 0.05)., Conclusions: 1. IL-17 is a newly cytokine which expressed in mucosa of allergic rhinitis and nasal polyps tissue. It indicates the degree of immunological reaction and inflammatory reaction, and can be used as an index to research the mechanism of nasal polyps as well as allergic rhinitis. 2. The eosinophilic cells count was correlated with the amount of IL-17 positive cells in nasal polyps and with allergic rhinitis correlation coefficients were R = 0. 606 (P < 0 01)and R = 0.446 (P < 0.05) respectively. It seems that eosinophils, which are regulated by IL-17, play an important roles in the development of nasal polyps and allergic rhinitis.
- Published
- 2010
42. [Clinical treatment and diagnosis of parapharyngeal space neoplasms (analysis of 62 cases)].
- Author
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Ba L, Liang C, and Liu Yf
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Humans, Male, Middle Aged, Retrospective Studies, Young Adult, Pharyngeal Neoplasms diagnosis, Pharyngeal Neoplasms surgery
- Abstract
Objective: To investigate the diagnosis and treatment of parapharyngeal space neoplasms which are rarely seen clinically and close related to the anatomy of parapharyngeal space., Method: A retrospective review was carried out on 62 patients with parapharyngeal space neoplasms removal from January 1995 to December 2005., Result: Neurogenic neoplasms were the most common tumors of the parapharyngeal space neoplasms, which constituted about 49 percent of all cases. All patients were treated successfully except 2 patients who suffered from tumor recurrence and received reoperation., Conclusion: Clinical manifestations of parapharyngeal space neoplasms were complicated and pathological types of which were diversified. Computed tomography and magnetic resonance imaging were essential for diagnosis of parapharyngeal space neoplasms. The presurgical planning was decided on the position and the pathological type of the neoplasms.
- Published
- 2007
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