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Background: Mental health was closely associated with cardiovascular disease (CVD). We aimed to investigate the association between cardiovascular health (CVH), as defined by Life's Essential 8 (LE8), and the presence of depression and anxiety. Hypothesis: We hypothesized that CVH, as defined by LE8, was negatively associated with the prevalence of depression and anxiety. Methods: A cross‐sectional study was conducted on participants (≥ 20 years old) from the National Health and Nutrition Examination Survey (NHANES). The LE8 score (ranging from 0 to 100) was composed of the health behavior score and the health factor score, which were further categorized into three levels as follows: low (0–49), moderate (50–79), and high (80–100). Weighted multivariable logistic regressions and restricted cubic splines were utilized to assess the association between LE8 and mental disorders. Results: Among the 13 028 participants included in this research, 1206 were determined to have depression symptoms and 2947 were determined to have anxiety symptoms. In the weighted and adjusted model, LE8 was negatively associated with the prevalence of depression (odds ratio [OR], 95% confidence interval [CI]: 0.61, 0.58–0.65) and anxiety (OR, 95% CI: 0.78, 0.75–0.81). Furthermore, a nonlinear dose–response relationship was observed between LE8 and anxiety. Conclusions: CVH defined by the LE8 was independently and negatively associated with the prevalence of depression and anxiety. Interventions targeting LE8 components may improve both CVH and mental health. [ABSTRACT FROM AUTHOR]

Background: Colorectal cancer (CRC) is among the most hackneyed malignancies. Even patients with identical clinical symptoms and the same TNM stage still exhibit radically different clinical outcomes after receiving equivalent treatment regimens, indicating extensive heterogeneity of CRC. Myriad molecular subtypes of CRC have been exploited for decades, including the most compelling consensus molecular subtype (CMS) classification that has been broadly applied for patient stratification and biomarker‐drug combination formulation. Encountering barriers to clinical translation, however, CMS classification fails to fully reflect inter‐ or intra‐tumor heterogeneity of CRC. As a consequence, addressing heterogeneity and precisely managing CRC patients with unique characteristics remain arduous tasks for clinicians. Review: In this review, we systematically summarize molecular subtypes of CRC and further elaborate on their clinical applications, limitations, and future orientations. Conclusion: In recent years, exploration of subtypes through cell lines, animal models, patient‐derived xenografts (PDXs), organoids, and clinical trials contributes to refining biological insights and unraveling subtype‐specific therapies in CRC. Therapeutic interventions including nanotechnology, clustered regulatory interspaced short palindromic repeat/CRISPR‐associated nuclease 9 (CRISPR/Cas9), gut microbiome, and liquid biopsy are powerful tools with the possibility to shift the immunologic landscape and outlook for CRC precise medicine. [ABSTRACT FROM AUTHOR]

While the literature generally acknowledges that target groups affect policy implementation, we argue that a more detailed investigation of the mechanisms and factors associated with such effect is necessary. Drawing on the Ambiguity-Conflict Model, we explore how target groups' perceived policy ambiguity and conflict relate to the implementation of Corporate Employee Pension (CEP) policies in China. Empirically, we utilize a unique sample of all firms listed on China's A-stock market from 2008 to 2014 and hypothesize that target groups' perceived policy ambiguity and conflict negatively associate with the implementation outcomes of the CEP policies in China. Our results confirm such a relationship and suggest that the implementation outcomes, from most favorable to least favorable, follow the order: Administrative Implementation, Political Implementation or Experimental Implementation, and Symbolic Implementation. Such results are robust to both state-owned and non-state-owned enterprises. Our research offers implications for both scholars and practitioners of pension policies in China. [ABSTRACT FROM AUTHOR]

Prior research has documented involvement of government and civil society actors in governance processes, but has largely neglected a key player: corporate business interests. Combining insights from social-ecological systems, organizational systems theory, theories of governance and power, interest group rule-making participation, and non-state alternative environmental governance, we examine corporate involvement and power in environmental governance systems. Drawing on a sample of Twitter messages about fuel economy standards, posted between 2012 and 2020, we offer a sector-level discourse analysis of corporate power and its interaction with the sociopolitical environment. The results suggest that business interests are gaining increasing power in the participation arena of U.S. fuel economy governance processes. The results likewise indicate corporations' response to a changing political landscape in the U.S. Taken together, our analysis advances current scholarship on power dynamics in governance processes and on empirical assessment of power, offering implications for governance system design and implementation. [ABSTRACT FROM AUTHOR]

The growing reliance on non-state environmental governance (EG) coupled with the current U.S. political environment portends an increasing salience of governing efforts from non-state actors. Among non-state actors, corporations play a substantial role given their market and societal power, their corresponding social responsibilities, and their organizational and institutional adaptability in developing and performing EG solutions. This article proposes a corporate-led environmental governance (CLEG) model. An important distinction between previous iterations of corporate social responsibility (CSR) and corporate governance and the CLEG model proposed here is the active assertion of corporate environmental leadership as state leadership is subject to retrenchment in the United States. [ABSTRACT FROM AUTHOR]

Policy innovation and diffusion literature mainly focuses on the decision to adopt a new policy, while ignoring the differences among new policies. This study divides the decision-making process of policy innovation diffusion into two phases: in the "innovate or not" phase, governments make the decision to adopt or reject the new policy, while "how to innovate" is the process by which governments formulate specific content for the new policy. A dynamic comparative analysis finds that effects of internal determinants and diffusion mechanisms vary during these two phases and that internal determinants moderate the effects of diffusion mechanisms. [ABSTRACT FROM AUTHOR]