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Infectious diseases with bacterial origin are one of the leading causes of death worldwide, with about 17 million deaths each year. Beside these bacterial infections, several parasitic infections deserve special attention due to a lack of effective treatments. Among these infections, human African trypanosomiasis, or sleeping sickness, and leishmaniasis have a strong impact on morbimortality and makes them a public health problem. These infectious diseases, which are part of the neglected tropical diseases, urgently need to be addressed through research and development of new antibiotics and antiparasitics. The search for new drugs can be based on plant biodiversity, which is an inexhaustible reserve of bioactive natural products. Africa, and Senegal in particular, is rich in many medicinal plants used by traditional medicine in the treatment of infectious diseases. [...]

Background: 1,2,3-triazoles are five-membered heterocyclic scaffold; their broad-spectrum biological activities are known. Researchers around the world are increasingly being interested in this emerging area, owing to its immense pharmacological scope. Objective: This work summarizes the synthesis of 1,2,3-triazoles and the significance of this pattern as a lead structure for new drug molecules discovery. Methods: 1,2,3-triazoles can be obtained on a multigram scale through “click chemistry” under ambient conditions. Results: Sixteen compounds were synthesized and evaluated on five microbial strains E. coli, E. faecalis, P. aeruginosa, S. aureus and C. albicans. NMR, MS and IR were used to characterize all compounds. They were evaluated with their Minimum Inhibitory Concentrations (MICs) and interesting results were obtained with compounds 12a, 12b, 3, 2a and 2c, with MIC 0.14 μM (P. aeruginosa), 1.08 μM (E. coli), 1.20 μM (E. faecalis and C. albicans), 3.5 μM (E. faecalis) and 4.24 μM (C. albicans), respectively. P. aeruginosa and C. albicans were the most sensitive among all the strains. Conclusion: The synthesized compounds were found as potential antimicrobial agents against Gram (+), Gram (-) strains and fungi.