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1. Aggressive fluid hydration plus non-steroidal anti-inflammatory drugs versus non-steroidal anti-inflammatory drugs alone for post-endoscopic retrograde cholangiopancreatography pancreatitis (FLUYT): a multicentre, open-label, randomised, controlled trial

Author

Sperna Weiland, Christina J, Smeets, Xavier J N M, Kievit, Wietske, Verdonk, Robert C, Poen, Alexander C, Bhalla, Abha, Venneman, Niels G, Witteman, Ben J M, da Costa, David W, van Eijck, Brechje C, Schwartz, Matthijs P, Römkens, Tessa E H, Vrolijk, Jan Maarten, Hadithi, Muhammed, Voorburg, Annet M C J, Baak, Lubbertus C, Thijs, Willem J, van Wanrooij, Roy L, Tan, Adriaan C I T L, Seerden, Tom C J, Keulemans, Yolande C A, de Wijkerslooth, Thomas R, van de Vrie, Wim, van der Schaar, Peter, van Dijk, Sven M, Hallensleben, Nora D L, Sperna Weiland, Ruud L, Timmerhuis, Hester C, Umans, Devica S, van Hooft, Jeanin E, van Goor, Harry, van Santvoort, Hjalmar C, Besselink, Marc G, Bruno, Marco J, Fockens, Paul, Drenth, Joost P H, and van Geenen, Erwin J M

Published
2021
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2. Socio‐economic factors associated with loss to follow‐up among individuals with HCV: A Dutch nationwide cross‐sectional study.

Author

van Dijk, Marleen, Boyd, Anders, Brakenhoff, Sylvia M., Isfordink, Cas J., van Zoest, Rosan A., Verhagen, Mark D., de Knegt, Robert J., Drenth, Joost P. H., van der Valk, Marc, van Wijngaarden, Peter, Douma, Renée A., Erkelens, Willemien G., Lammers, Adriana J. J., de Jonge, Hendrik J. M., Bus, Paul J., den Hollander, Jan G., Posthouwer, Dirk, Klemt‐Kropp, Michael, and Baak, Lubbertus C.

Subjects
SOCIOECONOMIC factors, INCOME, HEPATITIS C virus, CROSS-sectional method, DEATH rate
Abstract

Background and Aims: The path to hepatitis C virus (HCV) elimination is complicated by individuals who become lost to follow‐up (LTFU) during care, particularly before receiving effective HCV treatment. We aimed to determine factors contributing to LTFU and whether LTFU is associated with mortality. Methods: In this secondary analysis, we constructed a database including individuals with HCV who were either LTFU (data from the nationwide HCV retrieval project, CELINE) or treated with directly acting antivirals (DAA) (data from Statistics Netherlands) between 2012 and 2019. This database was linked to mortality data from Statistics Netherlands. Determinants associated with being LTFU versus DAA‐treated were assessed using logistic regression, and mortality rates were compared between groups using exponential survival models. These analyses were additionally stratified on calendar periods: 2012–2014, 2015–2017 and 2018–2019. Results: About 254 individuals, LTFU and 5547 DAA‐treated were included. Being institutionalized (OR = 5.02, 95% confidence interval (CI) = 3.29–7.65), household income below the social minimum (OR = 1.96, 95% CI = 1.25–3.06), receiving benefits (OR = 1.74, 95% CI = 1.20–2.52) and psychiatric comorbidity (OR = 1.51, 95% CI = 1.09–2.10) were associated with LTFU. Mortality rates were significantly higher in individuals LTFU compared to those DAA‐treated (2.99 vs. 1.15/100 person‐years (PY), p <.0001), while in those DAA‐treated, mortality rates slowly increased between 2012–2014 (.22/100PY) and 2018–2019 (2.25/100PY). Conclusion: In the Netherlands, individuals who are incarcerated/institutionalized, with low household income, or with psychiatric comorbidities are prone to being LTFU, which is associated with higher mortality. HCV care needs to be adapted for these vulnerable individuals. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Fluid hydration to prevent post-ERCP pancreatitis in average- to high-risk patients receiving prophylactic rectal NSAIDs (FLUYT trial): study protocol for a randomized controlled trial

Author

Smeets, Xavier J. N. M., da Costa, David W., Fockens, Paul, Mulder, Chris J. J., Timmer, Robin, Kievit, Wietske, Zegers, Marieke, Bruno, Marco J., Besselink, Marc G. H., Vleggaar, Frank P., van der Hulst, Rene W. M., Poen, Alexander C., Heine, Gerbrand D. N., Venneman, Niels G., Kolkman, Jeroen J., Baak, Lubbertus C., Römkens, Tessa E. H., van Dijk, Sven M., Hallensleben, Nora D. L., van de Vrie, Wim, Seerden, Tom C. J., Tan, Adriaan C. I. T. L., Voorburg, Annet M. C. J., Poley, Jan-Werner, Witteman, Ben J., Bhalla, Abha, Hadithi, Muhammed, Thijs, Willem J., Schwartz, Matthijs P., Vrolijk, Jan Maarten, Verdonk, Robert C., van Delft, Foke, Keulemans, Yolande, van Goor, Harry, Drenth, Joost P. H., van Geenen, Erwin J. M., and for the Dutch Pancreatitis Study Group

Published
2018
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7. ID: 3520219 A RANDOMIZED TRIAL OF AGGRESSIVE FLUID HYDRATION TO PREVENT POST-ERCP PANCREATITIS (FLUYT)

Author

Sperna Weiland, Christa J., primary, Smeets, Xavier, additional, Kievit, Wietske, additional, Verdonk, Robert C., additional, Poen, A.C., additional, Bhalla, Abha, additional, Venneman, Niels G., additional, Witteman, Ben, additional, da Costa, David W., additional, van Eijck, Brechje, additional, Schwartz, Matthijs P., additional, Romkens, Tessa, additional, Vrolijk, Jan, additional, Hadithi, Muhammed, additional, Voorburg, Annet, additional, Baak, Lubbertus C., additional, Thijs, Willem, additional, Wanrooij, Roy V., additional, Tan, Adriaan C., additional, Seerden, Tom, additional, Keulemans, Yolande, additional, De Wijkerslooth, Thomas R., additional, Van De Vrie, W., additional, Van Der Schaar, Peter J., additional, Van Dijk, Sven M., additional, Hallensleben, Nora D., additional, Sperna Weiland, Ruud L., additional, Timmerhuis, Hester C., additional, Umans, Devica S., additional, van Hooft, Jeanin E., additional, van Goor, Harry, additional, Van Santvoort, Hjalmar C., additional, Besselink, Marc G., additional, Bruno, Marco J., additional, Fockens, Paul, additional, Drenth, Joost, additional, and Van Geenen, Erwin-Jan M., additional

Published
2021
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9. Aggressive fluid hydration plus non-steroidal anti-inflammatory drugs versus non-steroidal anti-inflammatory drugs alone for post-endoscopic retrograde cholangiopancreatography pancreatitis (FLUYT):a multicentre, open-label, randomised, controlled trial

Author

Sperna Weiland, Christina J., Smeets, Xavier J.N.M., Kievit, Wietske, Verdonk, Robert C., Poen, Alexander C., Bhalla, Abha, Venneman, Niels G., Witteman, Ben J.M., da Costa, David W., van Eijck, Brechje C., Schwartz, Matthijs P., Römkens, Tessa E.H., Vrolijk, Jan Maarten, Hadithi, Muhammed, Voorburg, Annet M.C.J., Baak, Lubbertus C., Thijs, Willem J., van Wanrooij, Roy L., Tan, Adriaan C.I.T.L., Seerden, Tom C.J., Keulemans, Yolande C.A., de Wijkerslooth, Thomas R., van de Vrie, Wim, van der Schaar, Peter, van Dijk, Sven M., Hallensleben, Nora D.L., Sperna Weiland, Ruud L., Timmerhuis, Hester C., Umans, Devica S., van Hooft, Jeanin E., van Goor, Harry, van Santvoort, Hjalmar C., Besselink, Marc G., Bruno, Marco J., Fockens, Paul, Drenth, Joost P.H., van Geenen, Erwin J.M., Sperna Weiland, Christina J., Smeets, Xavier J.N.M., Kievit, Wietske, Verdonk, Robert C., Poen, Alexander C., Bhalla, Abha, Venneman, Niels G., Witteman, Ben J.M., da Costa, David W., van Eijck, Brechje C., Schwartz, Matthijs P., Römkens, Tessa E.H., Vrolijk, Jan Maarten, Hadithi, Muhammed, Voorburg, Annet M.C.J., Baak, Lubbertus C., Thijs, Willem J., van Wanrooij, Roy L., Tan, Adriaan C.I.T.L., Seerden, Tom C.J., Keulemans, Yolande C.A., de Wijkerslooth, Thomas R., van de Vrie, Wim, van der Schaar, Peter, van Dijk, Sven M., Hallensleben, Nora D.L., Sperna Weiland, Ruud L., Timmerhuis, Hester C., Umans, Devica S., van Hooft, Jeanin E., van Goor, Harry, van Santvoort, Hjalmar C., Besselink, Marc G., Bruno, Marco J., Fockens, Paul, Drenth, Joost P.H., and van Geenen, Erwin J.M.

Abstract

Background: Pancreatitis is the most common complication of endoscopic retrograde cholangiopancreatography (ERCP). Prophylactic rectal administration of non-steroidal anti-inflammatory drugs (NSAIDs) is considered as standard of care to reduce the risk of post-ERCP pancreatitis. It has been suggested that aggressive hydration might further reduce this risk. Guidelines already recommend aggressive hydration in patients who are unable to receive rectal NSAIDs, although it is laborious and time consuming. We aimed to evaluate the added value of aggressive hydration in patients receiving prophylactic rectal NSAIDs. Methods: FLUYT, a multicentre, open-label, randomised, controlled trial done across 22 Dutch hospitals, included patients aged between 18 and 85 years with moderate to high risk of post-ERCP pancreatitis. Patients were randomly assigned (1:1) by a web-based module with varying block sizes to a combination of aggressive hydration and rectal NSAIDs (100 mg diclofenac or indomethacin; aggressive hydration group) or rectal NSAIDs (100 mg diclofenac or indomethacin) alone (control group). Randomisation was stratified according to treatment centre. Aggressive hydration comprised 20 mL/kg intravenous Ringer's lactate solution within 60 min from the start of ERCP, followed by 3 mL/kg per h for 8 h. The control group received normal intravenous saline with a maximum of 1·5 mL/kg per h and 3 L per 24 h. The primary endpoint was post-ERCP pancreatitis and was analysed on a modified intention-to-treat basis (including all patients who underwent randomisation and an ERCP and for whom data regarding the primary outcome were available). The trial is registered with the ISRCTN registry, ISRCTN13659155. Findings: Between June 5, 2015, and June 6, 2019, 826 patients were randomly assigned, of whom 388 in the aggressive hydration group and 425 in the control group were included in the modified intention-to-treat analysis. Post-ERCP pancreatitis occurred in 30 (8%) patients i

Published
2021

11. Sa1135 – Genomic Biomarkers for Cancer Risk in Barrett's Esophagus: An Update on the Longitudinal Dutch Barrett's Esophagus Cohort

Author

Hoefnagel, Sanne, primary, Westra, Wytske H., additional, Timmer, Margriet R., additional, Martinez, Pierre, additional, Klaver, Esther, additional, Calpe, Silvia, additional, del Carmen Sancho-Serra, Maria, additional, Straub, Danielle, additional, Baker, Ann-Marie, additional, Rosmolen, Wilda, additional, Meijer, Sybren L., additional, Kate, Fiebo Ten, additional, Dijkgraaf, Marcel, additional, Mallant-Hent, Rosalie, additional, Naber, Anton H., additional, van Oijen, Arnoud, additional, Baak, Lubbertus C., additional, Scholten, Pieter, additional, Böhmer, Clarisse, additional, Maley, Carlo, additional, Graham, Trevor A., additional, Bergman, Jacques, additional, and Krishnadath, Kausilia K., additional

Published
2019
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12. 11 - Clinical and Endoscopic Predictors of Neoplastic Progression in Barrett's Esophagus Surveillance: A Multicenter Community Based Prospective Cohort Study

Author

Klaver, Esther, primary, Gonzalez, Angela Bureo, additional, Mallant-Hent, Rosalie, additional, Baak, Lubbertus C., additional, Böhmer, Clarisse, additional, van Oijen, Arnoud, additional, Naber, Anton H., additional, Scholten, Pieter, additional, Duits, Lucas C., additional, Bergman, Jacques, additional, and Pouw, Roos E., additional

Published
2018
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13. Fluid hydration to prevent post-ERCP pancreatitis in average- to high-risk patients receiving prophylactic rectal NSAIDs (FLUYT trial) : study protocol for a randomized controlled trial

Author

Smeets, Xavier J N M, da Costa, David W, Fockens, Paul, Mulder, Chris J J, Timmer, Robin, Kievit, Wietske, Zegers, Marieke, Bruno, Marco J, Besselink, Marc G H, Vleggaar, Frank P, van der Hulst, Rene W M, Poen, Alexander C, Heine, Gerbrand D N, Venneman, Niels G, Kolkman, Jeroen J, Baak, Lubbertus C, Römkens, Tessa E H, van Dijk, Sven M, Hallensleben, Nora D L, van de Vrie, Wim, Seerden, Tom C J, Tan, Adriaan C I T L, Voorburg, Annet M C J, Poley, Jan-Werner, Witteman, Ben J, Bhalla, Abha, Hadithi, Muhammed, Thijs, Willem J, Schwartz, Matthijs P, Vrolijk, Jan Maarten, Verdonk, Robert C, van Delft, Foke, Keulemans, Yolande, van Goor, Harry, Drenth, Joost P H, van Geenen, Erwin J M, Dutch Pancreatitis Study Group, Smeets, Xavier J N M, da Costa, David W, Fockens, Paul, Mulder, Chris J J, Timmer, Robin, Kievit, Wietske, Zegers, Marieke, Bruno, Marco J, Besselink, Marc G H, Vleggaar, Frank P, van der Hulst, Rene W M, Poen, Alexander C, Heine, Gerbrand D N, Venneman, Niels G, Kolkman, Jeroen J, Baak, Lubbertus C, Römkens, Tessa E H, van Dijk, Sven M, Hallensleben, Nora D L, van de Vrie, Wim, Seerden, Tom C J, Tan, Adriaan C I T L, Voorburg, Annet M C J, Poley, Jan-Werner, Witteman, Ben J, Bhalla, Abha, Hadithi, Muhammed, Thijs, Willem J, Schwartz, Matthijs P, Vrolijk, Jan Maarten, Verdonk, Robert C, van Delft, Foke, Keulemans, Yolande, van Goor, Harry, Drenth, Joost P H, van Geenen, Erwin J M, and Dutch Pancreatitis Study Group

Published
2018

14. Fluid hydration to prevent post-ERCP pancreatitis in average- to high-risk patients receiving prophylactic rectal NSAIDs (FLUYT trial): study protocol for a randomized controlled trial

Author

Arts-assistenten Radiologie, MS CGO, Cancer, Smeets, Xavier J N M, da Costa, David W, Fockens, Paul, Mulder, Chris J J, Timmer, Robin, Kievit, Wietske, Zegers, Marieke, Bruno, Marco J, Besselink, Marc G H, Vleggaar, Frank P, van der Hulst, Rene W M, Poen, Alexander C, Heine, Gerbrand D N, Venneman, Niels G, Kolkman, Jeroen J, Baak, Lubbertus C, Römkens, Tessa E H, van Dijk, Sven M, Hallensleben, Nora D L, van de Vrie, Wim, Seerden, Tom C J, Tan, Adriaan C I T L, Voorburg, Annet M C J, Poley, Jan-Werner, Witteman, Ben J, Bhalla, Abha, Hadithi, Muhammed, Thijs, Willem J, Schwartz, Matthijs P, Vrolijk, Jan Maarten, Verdonk, Robert C, van Delft, Foke, Keulemans, Yolande, van Goor, Harry, Drenth, Joost P H, van Geenen, Erwin J M, Dutch Pancreatitis Study Group, Arts-assistenten Radiologie, MS CGO, Cancer, Smeets, Xavier J N M, da Costa, David W, Fockens, Paul, Mulder, Chris J J, Timmer, Robin, Kievit, Wietske, Zegers, Marieke, Bruno, Marco J, Besselink, Marc G H, Vleggaar, Frank P, van der Hulst, Rene W M, Poen, Alexander C, Heine, Gerbrand D N, Venneman, Niels G, Kolkman, Jeroen J, Baak, Lubbertus C, Römkens, Tessa E H, van Dijk, Sven M, Hallensleben, Nora D L, van de Vrie, Wim, Seerden, Tom C J, Tan, Adriaan C I T L, Voorburg, Annet M C J, Poley, Jan-Werner, Witteman, Ben J, Bhalla, Abha, Hadithi, Muhammed, Thijs, Willem J, Schwartz, Matthijs P, Vrolijk, Jan Maarten, Verdonk, Robert C, van Delft, Foke, Keulemans, Yolande, van Goor, Harry, Drenth, Joost P H, van Geenen, Erwin J M, and Dutch Pancreatitis Study Group

Published
2018

15. Dynamic clonal equilibrium and predetermined cancer risk in Barrett’s oesophagus

Author

Martinez, Pierre, primary, Timmer, Margriet R., additional, Lau, Chiu T., additional, Calpe, Silvia, additional, Sancho-Serra, Maria del Carmen, additional, Straub, Danielle, additional, Baker, Ann-Marie, additional, Meijer, Sybren L., additional, Kate, Fiebo J. W. ten, additional, Mallant-Hent, Rosalie C., additional, Naber, Anton H. J., additional, van Oijen, Arnoud H. A. M., additional, Baak, Lubbertus C., additional, Scholten, Pieter, additional, Böhmer, Clarisse J. M., additional, Fockens, Paul, additional, Bergman, Jacques J. G. H. M., additional, Maley, Carlo C., additional, Graham, Trevor A., additional, and Krishnadath, Kausilia K, additional

Published
2016
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16. 139 Longitudinal Single Cell Clonal Analysis Reveals Evolutionary Stasis and Re-Determined Malignant Potential in Non-Dysplastic Barrett's Esophagus

Author

Timmer, Margriet R., primary, Martinez, Pierre, additional, Lau, Liana, additional, Meijer, Sybren L., additional, Ten Kate, Fiebo, additional, Mallant-Hent, Rosalie, additional, Naber, Anton H., additional, van Oijen, Martijn G., additional, Baak, Lubbertus C., additional, Scholten, Pieter, additional, Böhmer, Clarisse, additional, Fockens, Paul, additional, Bergman, Jacques, additional, Maley, Carlo, additional, Graham, Trevor A., additional, and Krishnadath, Kausilia K., additional

Published
2016
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17. Derivation of genetic biomarkers for cancer risk stratification in Barrett’s oesophagus: a prospective cohort study

Author

Timmer, Margriet R, primary, Martinez, Pierre, additional, Lau, Chiu T, additional, Westra, Wytske M, additional, Calpe, Silvia, additional, Rygiel, Agnieszka M, additional, Rosmolen, Wilda D, additional, Meijer, Sybren L, additional, ten Kate, Fiebo J W, additional, Dijkgraaf, Marcel G W, additional, Mallant-Hent, Rosalie C, additional, Naber, Anton H J, additional, van Oijen, Arnoud H A M, additional, Baak, Lubbertus C, additional, Scholten, Pieter, additional, Böhmer, Clarisse J M, additional, Fockens, Paul, additional, Maley, Carlo C, additional, Graham, Trevor A, additional, Bergman, Jacques J G H M, additional, and Krishnadath, Kausilia K, additional

Published
2015
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18. Tu1311 A FISH Biomarker Panel for Distinguishing Different Stages of Dysplasia in Barrett's Esophagus

Author

Timmer, Margriet R., primary, Lau, Chiu Ting, additional, Rosmolen, Wilda, additional, Meijer, Sybren L., additional, Dijkgraaf, Marcel G., additional, Mallant-Hent, Rosalie C., additional, Naber, Anton H., additional, Van Oijen, Arnoud H., additional, Baak, Lubbertus C., additional, Scholten, Pieter, additional, BöHmer, Clarisse, additional, Fockens, Paul, additional, Bergman, Jacques J., additional, and Krishnadath, Kausilia K., additional

Published
2014
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19. 164 A FISH Biomarker Panel for the Prediction of High-grade Dysplasia and Adenocarcinoma in Non-Dysplastic Barrett's Esophagus; Results From a Long-Term Prospective Cohort Study

Author

Timmer, Margriet R., primary, Lau, Chiu Ting, additional, Rosmolen, Wilda, additional, Meijer, Sybren L., additional, Dijkgraaf, Marcel G., additional, Mallant-Hent, Rosalie C., additional, Naber, Anton H., additional, Van Oijen, Arnoud H., additional, Baak, Lubbertus C., additional, Scholten, Pieter, additional, BöHmer, Clarisse, additional, Fockens, Paul, additional, Bergman, Jacques J., additional, and Krishnadath, Kausilia K., additional

Published
2014
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20. Derivation of genetic biomarkers for cancer risk stratification in Barrett's oesophagus: a prospective cohort study.

Author

Timmer, Margriet R., Martinez, Pierre, Lau, Chiu T., Westra, Wytske M., Calpe, Silvia, Rygiel, Agnieszka M., Rosmolen, Wilda D., Meijer, Sybren L., ten Kate, Fiebo J. W., Dijkgraaf, Marcel G. W., Mallant-Hent, Rosalie C., Naber, Anton H. J., van Oijen, Arnoud H. A. M., Baak, Lubbertus C., Scholten, Pieter, Böhmer, Clarisse J. M., Fockens, Paul, Maley, Carlo C., Graham, Trevor A., and Bergman, Jacques J. G. H. M.

Subjects
BARRETT'S esophagus, GENETIC markers, CANCER risk factors, DISEASE progression, ENDOSCOPY, DIAGNOSIS, THERAPEUTICS
Published
2016
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21. CT colonography with limited bowel preparation: prospective assessment of patient experience and preference in comparison to optical colonoscopy with cathartic bowel preparation

Author

Jensch, Sebastiaan, primary, Bipat, Shandra, additional, Peringa, Jan, additional, de Vries, Ayso H., additional, Heutinck, Anneke, additional, Dekker, Evelien, additional, Baak, Lubbertus C., additional, Montauban van Swijndregt, Alexander D., additional, and Stoker, Jaap, additional

Published
2009
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22. Does a computer-aided detection algorithm in a second read paradigm enhance the performance of experienced computed tomography colonography readers in a population of increased risk?

Author

de Vries, Ayso H., primary, Jensch, Sebastiaan, additional, Liedenbaum, Marjolein H., additional, Florie, Jasper, additional, Nio, Chung Y., additional, Truyen, Roel, additional, Bipat, Shandra, additional, Dekker, Evelien, additional, Fockens, Paul, additional, Baak, Lubbertus C., additional, and Stoker, Jaap, additional

Published
2008
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25. MR Colonography with Limited Bowel Preparation Compared with Optical Colonoscopy in Patients at Increased Risk for Colorectal Cancer

Author

Florie, Jasper, primary, Jensch, Sebastiaan, additional, Nievelstein, Rutger A. J., additional, Bartelsman, Joep F., additional, Baak, Lubbertus C., additional, van Gelder, Rogier E., additional, Haberkorn, Brigitte, additional, van Randen, Adrienne, additional, van der Ham, Michiel M., additional, Snel, Pleun, additional, van der Hulst, Victor P. M., additional, Bossuyt, Patrick M. M., additional, and Stoker, Jaap, additional

Published
2007
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28. Attenuation of the gastric acid and serum gastrin – lowering effects of the prostaglandin E2analog enprostil

Author

Baak, Lubbertus C, Jansen, Jan B M J, Meijer, Jan L, and Lamers, Cornelis B H W

Abstract

Enprostil, a synthetic prostaglandin E2analog, has been shown to decrease gastric acid secretion and plasma gastrin levels during short-term treatment. However, effects of prolonged treatment with enprostil on these parameters in humans are unknown. We have studied the effects of 35 µg enprostil twice daily on 24-hour intragastric pH, basal gastrin, and meal-stimulated gastrin release in 10 healthy volunteers. Enprostil, 35 µg, was ingested twice daily for 4 weeks. Subjects were studied on day 0 (preentry) and days 1 and 29, when enprostil was taken 30 minutes before the first and third standard test meals at 9 AM and 5 PM. Enprostil significantly increased 24-hour median pH (p < 0.02) on day 1 but not on day 29. Enprostil had no significant effect on basal gastrin levels compared with placebo. However, on day 1, but not on day 29, postprandial gastrin levels were significantly lower compared with preentry (p < 0.05). On day 29 postprandial gastrin levels after the second standard test meal were significantly higher compared with preentry data (p < 0.05). In conclusion, 35 µg enprostil twice daily reduced gastric acidity and serum gastrin levels on the first day of treatment, but this effect attenuated and even transiently reversed during a 4-week treatment period.

Published
1993
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